1,593 results match your criteria International journal of medical sciences[Journal]


Gene Expression Profiling in Ischemic Postconditioning to Alleviate Mouse Liver Ischemia/Reperfusion Injury.

Int J Med Sci 2019 24;16(2):343-354. Epub 2019 Jan 24.

Department of Transplant Surgery, The Third Xiangya Hospital of Central South University, Changsha 410013, China.

Ischemic postconditioning (IPO) attenuates hepatic ischemia/reperfusion (I/R) injury. However, little is known about the underlying biological pathophysiology, which could be, at least in part, informed by exploring the transcriptomic changes using next-generation RNA sequencing (RNA-Seq). In this study, 18 mice (C57BL/6) were involved and randomly assigned to three groups: normal (n=6), I/R (n=6, subjected to 70% hepatic I/R), and IR+IPO (n=6, applying IPO to mice with I/R injury). Read More

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http://dx.doi.org/10.7150/ijms.29393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367534PMC
January 2019

Association between Anaesthetic Technique and Oncological Outcomes after Colorectal Carcinoma Liver Metastasis Resection.

Int J Med Sci 2019 24;16(2):337-342. Epub 2019 Jan 24.

Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, 225 Changhai Road, Shanghai, China.

Recently published studies suggest that the anaesthetic technique used during oncologic surgery can improve patient outcomes. Therefore, the authors evaluated the survival of patients with resected colorectal carcinoma liver metastases (CRCLMs) who received either EGA (general anaesthesia [GA] combined with epidural anaesthesia [EA]) or GA alone. We conducted an ambispective cohort study including 225 post-surgical CRCLM patients between May 2007 and July 2012 and performed a follow-up investigation of survival in July 2017. Read More

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http://dx.doi.org/10.7150/ijms.28016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367527PMC
January 2019

Correlation between genetic polymorphism of angiopoietin-2 gene and clinical aspects of rheumatoid arthritis.

Int J Med Sci 2019 1;16(2):331-336. Epub 2019 Jan 1.

Department of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.

The Angiopoietin-2 (Ang2) gene encodes angiogenic factor, and the polymorphisms of Ang2 gene predict risk of various human diseases. We want to investigate whether the single nucleotide polymorphisms (SNPs) of the Ang2 gene can predict the risk of rheumatoid arthritis (RA). Between 2016 and 2018, we recruited 335 RA patients and 700 control participants. Read More

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http://dx.doi.org/10.7150/ijms.30582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367530PMC
January 2019
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A Pilot Study of Aberrant CpG Island Hypermethylation of in Acute Myeloloid Leukemia.

Int J Med Sci 2019 1;16(2):324-330. Epub 2019 Jan 1.

Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, China.

Epigenetic silencing of tumor suppressor genes plays important role in acute myeloid leukemia (AML). Recently, SPRED1, a negative regulator of the RAS MAPK pathway, is identified as a tumour suppressor downregulated in AML. However, little is known regarding its underlying dysregulation in AML. Read More

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http://dx.doi.org/10.7150/ijms.27757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367533PMC
January 2019

Systemic Angiopoietin-1/2 Dysregulation in Pediatric Sepsis and Septic Shock.

Int J Med Sci 2019 1;16(2):318-323. Epub 2019 Jan 1.

Department of Medicine, University of Washington, Seattle, WA.

Angiopoietin-1 and -2 are vascular growth factors that exert opposing effects on endothelial activation and dysfunction. The aim of this study was to assess the association of these biomarkers with outcomes in children with sepsis. Biomarkers were assayed from the blood collected in an emergency department prior to any intervention. Read More

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http://dx.doi.org/10.7150/ijms.27731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367536PMC
January 2019

Feasible Advantage of Bioactive/Bioresorbable Devices Made of Forged Composites of Hydroxyapatite Particles and Poly-L-lactide in Alveolar Bone Augmentation: A Preliminary Study.

Int J Med Sci 2019 1;16(2):311-317. Epub 2019 Jan 1.

Division of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Takamatsu, Japan.

: We aimed to document the clinical usefulness of uncalcined and unsintered hydroxyapatite (u-HA) particles and poly-L-lactide (PLLA) composite materials and their advantageous properties. : Between April 2016 and March 2018, five patients required anterior maxillary alveolar ridge augmentation using fixation with u-HA/PLLA screws for an onlay block bone graft harvested from the mandibular ramus at our institute. Bone biopsies were obtained from the dental implantation site following bone healing for histomorphometric and immunohistochemical (IHC) measurements. Read More

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http://dx.doi.org/10.7150/ijms.27986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367538PMC
January 2019

Imbalance of erythropoiesis and iron metabolism in patients with thalassemia.

Int J Med Sci 2019 1;16(2):302-310. Epub 2019 Jan 1.

Department of Hematology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

This study aimed to evaluate the imbalance of erythropoiesis and iron metabolism in patients with thalassemia. 192 patients with non-transfusion-dependent thalassemia (NTDT), 94 patients with transfusion-dependent thalassemia (TDT) and 101 healthy controls were recruited between June 2013 and December 2016 in the Hematology Department, the First Affiliated Hospital of Guangxi Medical University. The groups were compared in terms of levels of erythropoiesis biomarkers [growth differentiation factor 15 (GDF15), erythropoietin (EPO) and soluble transferrin receptor (sTfR)] and of iron overload biomarkers [serum ferritin (SF), liver iron concentration (LIC) and cardiac T2*] and hepcidin. Read More

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http://dx.doi.org/10.7150/ijms.27829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367537PMC
January 2019

Circular RNA: a novel biomarker and therapeutic target for human cancers.

Int J Med Sci 2019 1;16(2):292-301. Epub 2019 Jan 1.

Department of Pathophysiology, Third Military Medical University, Chongqing 400038, China.

Circular (circ)RNAs, a newly recognized class of noncoding RNA, have been implicated in the occurrence and development of several diseases, including neurological and cardiovascular diseases. Studies of human tumors, including those of liver cancer, gastric cancer, lung cancer and colorectal cancer, have shown differential expression profiles of circRNAs, suggesting regulatory roles in cancer pathogenesis and metastasis. In this review, we discuss the most recent research into tumor-related circRNAs, providing a comprehensive summary of the expression or/and function of these circRNAs and proposing rational perspectives on the potential clinical application of circRNAs as helpful biomarkers or therapeutic targets in human tumors. Read More

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http://dx.doi.org/10.7150/ijms.28047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367529PMC
January 2019

Non-alcoholic fatty liver disease is associated with low-grade albuminuria in men without diabetes mellitus.

Int J Med Sci 2019 1;16(2):285-291. Epub 2019 Jan 1.

Division of Nephrology, Department of Internal Medicine, Yeungnam University Hospital, Daegu, Republic of Korea.

Non-alcoholic fatty liver disease (NAFLD) is associated with the dysregulation of multiple metabolic and inflammatory pathways. These can lead to extrahepatic disorders involving the kidney, a vulnerable organ responsible for extra-renal complications. Evaluating the association between NAFLD and low-grade albuminuria as a renal complication would be helpful to better understand the pathophysiology and extra-hepatic complications of NAFLD. Read More

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http://dx.doi.org/10.7150/ijms.28264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367539PMC
January 2019
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Von Willebrand Factor Adhesive Activity and ADAMTS13 Protease Activity in HIV-1-Infected Men.

Int J Med Sci 2019 1;16(2):276-284. Epub 2019 Jan 1.

Department of Medicine, University of Washington, Seattle, WA USA.

Endothelial activation caused by HIV-1 infection leads to release of von Willebrand factor (VWF), which enters the circulation or attaches to vessel walls and self-assembles into strings and fibers, enabling platelet adhesion; this adhesive activity is regulated by the VWF-cleaving protease ADAMTS13. Our objective was to assess VWF adhesive activity and ADAMTS13 protease activity in HIV-1 infection. We measured levels of VWF antigen, VWF activation factor (a measure of adhesive activity), ADAMTS13 antigen, ADAMTS13 activity, and apolipoprotein A1 (which interferes with VWF self-association) in serum samples from HIV-1-infected men whose infections were acute (n=10), chronic untreated (n=10), or chronic treated (n=10), compared to uninfected controls (n=10). Read More

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http://dx.doi.org/10.7150/ijms.28110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367531PMC
January 2019
1 Read

Platelet Reactivity And Circulating Platelet-Derived Microvesicles Are Differently Affected By P2Y Receptor Antagonists.

Int J Med Sci 2019 1;16(2):264-275. Epub 2019 Jan 1.

Second Department of Cardiology, Jagiellonian University Medical College, Cracow, Poland.

: Platelet-derived microvesicles (PMVs), shed from platelet surface membranes, constitute the majority of circulating microvesicles and have been implicated in procoagulant, pro-inflammatory and pro-atherosclerotic effects. Our aim was to compare plasma PMVs numbers in relation to platelet reactivity during dual antiplatelet therapy (DAPT) with various P2Y adenosine diphosphate (ADP) receptor antagonists. In pre-discharge men treated with DAPT for an acute coronary syndrome, plasma PMVs were quantified by flow cytometry on the basis of CD62P (P-selectin) and CD42 (glycoprotein Ib) positivity, putative indices of PMVs release from activated and all platelets, respectively. Read More

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http://dx.doi.org/10.7150/ijms.28580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367525PMC
January 2019

Temporomandibular Disorders and Oral Features in Early Rheumatoid Arthritis Patients: An Observational Study.

Int J Med Sci 2019 1;16(2):253-263. Epub 2019 Jan 1.

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, "Aldo Moro" University of Bari, Italy.

Temporomandibular disorders (TMD) represent a heterogeneous group of inflammatory or degenerative diseases of the stomatognatic system, with algic and/or dysfunctional clinical features involving temporomandibular joint (TMJ) and related masticatory muscles. Rheumatoid Arthritis (RA) is an autoimmune polyarthritis characterized by the chronic inflammation of synovial joints and oral implications such as hyposalivation, difficulty in swallowing and phoning, feeling of burning mouth, increased thirst, loss of taste or unpleasant taste and smell, dental sensitivity. The aim of this observational study was to investigate the prevalence of TMD symptoms and signs as well as oral implications in patients with Early Rheumatoid Arthritis (ERA), that is a RA diagnosed within 12 months, compared with a control group. Read More

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http://dx.doi.org/10.7150/ijms.28361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367523PMC
January 2019
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Reliability of Preoperative Inguinal Sonography for Evaluating Patency of Processus Vaginalis in Pediatric Inguinal Hernia Patients.

Int J Med Sci 2019 1;16(2):247-252. Epub 2019 Jan 1.

Department of Surgery, Konkuk University Chungju Hospital, Chungju, Republic of Korea.

: Among childhood illnesses requiring surgery, inguinal hernia is the most common entity. Pediatric inguinal hernia has been traditionally operated through a small incision in the inguinal region. Contralateral metachronous inguinal hernia has been the topic of discussion in pediatric surgeon's domain for a long time. Read More

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http://www.medsci.org/v16p0247.htm
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http://dx.doi.org/10.7150/ijms.28730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367528PMC
January 2019
4 Reads

MUC7 Level As A New Saliva Risk Factor For Dental Caries In Adult Patients.

Int J Med Sci 2019 1;16(2):241-246. Epub 2019 Jan 1.

Department of Medical Microbiology, University of Medical Sciences in Poznan, Poland.

: Data currently available indicate the significance of salivary mucins MUC5B and MUC7 in the protection of teeth against caries. Our study aimed to determine the relationship between dental caries in adults and levels of MUC5B and MUC7. : The studies were conducted on 45 adult subjects selected on the basis of dental examination and calculation of the DMFT (Decayed, Missing, and Filled Teeth) index. Read More

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http://dx.doi.org/10.7150/ijms.29027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367524PMC
January 2019

Anti-proliferative and Anti-invasive Effect of Polysaccharide-rich Extracts from in Colon Cancer Cells.

Int J Med Sci 2019 1;16(2):231-240. Epub 2019 Jan 1.

Epithelial Plasticity and Metastasis Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC).

Colorectal cancer (CRC) is one of leading causes of mortality in western countries and novel treatment strategies are required. The medicinal application of mushrooms has been used in traditional medicine in many oriental countries. Polysaccharide-rich extracts obtained from certain medicinal mushroom species have shown antitumor effects in different experimental models. Read More

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http://dx.doi.org/10.7150/ijms.28811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367522PMC
January 2019

A New Look at Causal Factors of Idiopathic Scoliosis: Altered Expression of Genes Controlling Chondroitin Sulfate Sulfation and Corresponding Changes in Protein Synthesis in Vertebral Body Growth Plates.

Int J Med Sci 2019 1;16(2):221-230. Epub 2019 Jan 1.

University of Pittsburgh, Pittsburgh PA, USA.

In a previous report, we demonstrated the presence of cells with a neural/glial phenotype on the concave side of the vertebral body growth plate in Idiopathic Scoliosis (IS) and proposed this phenotype alteration as the main etiological factor of IS. In the present study, we utilized the same specimens of vertebral body growth plates removed during surgery for Grade III-IV IS to analyse gene expression. We suggested that phenotype changes observed on the concave side of the vertebral body growth plate can be associated with altered expression of particular genes, which in turn compromise mechanical properties of the concave side. Read More

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http://dx.doi.org/10.7150/ijms.29312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367535PMC
January 2019

MicroRNA-29a is a key regulon that regulates BRD4 and mitigates liver fibrosis in mice by inhibiting hepatic stellate cell activation.

Int J Med Sci 2019 1;16(2):212-220. Epub 2019 Jan 1.

Core Laboratory for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, 833.

MicroRNA-29a is a key regulon that regulates hepatic stellate cells (HSCs) and mitigates liver fibrosis. However, the mechanism by which it does so remains largely undefined. The inhibition of bromodomain-4 protein (BRD4) represents a novel therapeutic target in hepatic fibrosis. Read More

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http://dx.doi.org/10.7150/ijms.29930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367521PMC
January 2019

Current status of endovascular treatment for dural arteriovenous fistulae in the anterior cranial fossa: A systematic literature review.

Int J Med Sci 2019 1;16(2):203-211. Epub 2019 Jan 1.

Department of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.

Anterior cranial fossa (ACF) dural arteriovenous fistulae (DAVFs) are rare, and a systematic review of the literature is lacking. Such a review is necessary, however, so a systematic PubMed search of related studies was performed. Twenty-four studies were identified, reporting on 48 patients, of whom 39 had definite age and sex information and 33 (84. Read More

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http://dx.doi.org/10.7150/ijms.29637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367520PMC
January 2019
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Retardation of Myopia Progression by Multifocal Soft Contact Lenses.

Int J Med Sci 2019 1;16(2):198-202. Epub 2019 Jan 1.

Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University (the Second People's Hospital of Yunnan Province); Yunnan Eye Institute; Key Laboratory of Yunnan Province for the Prevention and Treatment of ophthalmology (2017DG008); Provincial Innovation Team for Cataract and Ocular Fundus Disease, The Second People's Hospital of Yunnan Province (2017HC010); Expert Workstation of Yao Ke (2017IC064), Kunming 650021, China.

Myopia is an important public health problem due to its prevalence and significant public health cost. Elevating levels of myopia increase the risk of vision impairment, and therefore, high myopia has become one of the main causes of untreatable vision loss throughout the world due to its irreversible complications. At present, many options for slowing progression of myopia have already been proposed and evaluated such as progressive addition of executive bifocal spectacle lenses, peripheral defocusing lenses, overnight orthokeratology, pharmacological agents such as atropine eye drops, and multifocal soft contact lenses (MFSCLs). Read More

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http://dx.doi.org/10.7150/ijms.30118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367526PMC
January 2019

Antarctic freshwater microalga, , suppresses inflammation and carcinogenesis.

Int J Med Sci 2019 1;16(2):189-197. Epub 2019 Jan 1.

Division of Polar Life Sciences, Korea Polar Research Institute, Incheon, 21990, Republic of Korea.

Inflammation triggered by the innate immune system is a strategy to protect organisms from the risk of environmental infection. However, it has recently become clear that inflammation can cause a variety of human diseases, including cancer. In this study, we investigated the effects of an ethanol extract of the Antarctic freshwater microalgae, (ETCH), on inflammation and carcinogenesis in RAW 264. Read More

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http://dx.doi.org/10.7150/ijms.30647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367532PMC
January 2019

Nonselective Cyclooxygenase Inhibition Retards Cyst Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease.

Int J Med Sci 2019 1;16(1):180-188. Epub 2019 Jan 1.

Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.

Autosomal dominant polycystic kidney disease is one of the most common genetic renal diseases. Cyclooxygenase plays an important role in epithelial cell proliferation and may contribute to the mechanisms underlying cyst formation. The aim of the present study was to evaluate the role of cyclooxygenase inhibition in the cyst progression in polycystic kidney disease. Read More

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http://dx.doi.org/10.7150/ijms.27719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332488PMC
January 2019
2 Reads

Lipopolysaccharide promoted proliferation and adipogenesis of preadipocytes through JAK/STAT and AMPK-regulated cPLA2 expression.

Int J Med Sci 2019 1;16(1):167-179. Epub 2019 Jan 1.

Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan.

The proliferation and adipogenesis of preadipocytes played important roles in the development of adipose tissue and contributed much to the processes of obesity. On the other hand, lipopolysaccharide (LPS), also known as endotoxin, is a key outer membrane component of gram-negative bacteria in the gut microbiota, and has a dominant role in linking inflammation to high-fat diet-induced metabolic syndrome. Studies suggested the potential roles of LPS in hepatic steatosis and in obese mice models. Read More

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http://www.medsci.org/v16p0167.htm
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http://dx.doi.org/10.7150/ijms.24068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332489PMC
January 2019
3 Reads
2.003 Impact Factor

Shockwave Targeting on Subchondral Bone Is More Suitable than Articular Cartilage for Knee Osteoarthritis.

Int J Med Sci 2019 1;16(1):156-166. Epub 2019 Jan 1.

Section of Sports Medicine, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Our study compared the effects of extracorporeal shockwave therapy (ESWT) on the subchondral bone and the articular cartilage in the treatment of early osteoarthritis (OA) of rat knee. The rats were divided into 5 groups which included Sham group, Meniscus group (ESWT applied on medial meniscus), OA group (arthrotomy and medial menisectomy (MMx) and anterior cruciate ligament transection (ACLT), T(M) group (arthrotomy and MMx and ACLT followed by ESWT on medial tibial subchondral bone) and Articular cartilage group (arthrotomy and MMx and ACLT followed by ESWT on medial articular cartilage). Evaluations included the pathological changes of the synovium, articular cartilage and subchondral bone, and compared with ESWT on the meniscus, medial tibial subchondral bone and articular cartilage. Read More

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http://dx.doi.org/10.7150/ijms.26659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332487PMC
January 2019
1 Read

Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of baicalein against oxidative stress-induced DNA damage and apoptosis in HEI193 Schwann cells.

Int J Med Sci 2019 1;16(1):145-155. Epub 2019 Jan 1.

Anti-Aging Research Center and Department of Biochemistry, Dongeui University College of Korean Medicine, Busan 47227, Republic of Korea.

Baicalein, a flavonoid extracted from the roots of Georgi., has various pharmacological effects due to its high antioxidant activity. However, no study has yet been conducted on the protective efficacy of baicalein against oxidative stress in Schwann cells. Read More

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http://www.medsci.org/v16p0145.htm
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http://dx.doi.org/10.7150/ijms.27005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332480PMC
January 2019
5 Reads

Bilirubin Attenuates ER Stress-Mediated Inflammation, Escalates Apoptosis and Reduces Proliferation in the LS174T Colonic Epithelial Cell Line.

Int J Med Sci 2019 1;16(1):135-144. Epub 2019 Jan 1.

School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.

Mildly elevated serum unconjugated bilirubin (UCB) concentrations are associated with protection against disease conditions underpinned by cellular and metabolic stress. To determine the potential therapeutic efficacy of UCB we tested it in an model of gut inflammation. Tunicamycin TUN (10 µg/mL) was used to induce endoplasmic reticular stress (ERS) affecting N-glycosylation in LS174T cells. Read More

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http://www.medsci.org/v16p0135.htm
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http://dx.doi.org/10.7150/ijms.29134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332492PMC
January 2019
6 Reads
2.003 Impact Factor

The Effects of Naturalistic Light on Diurnal Plasma Melatonin and Serum Cortisol Levels in Stroke Patients during Admission for Rehabilitation: A Randomized Controlled Trial.

Int J Med Sci 2019 1;16(1):125-134. Epub 2019 Jan 1.

Clinical Stroke Research Unit, Department of Neurology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen.

Stroke patients admitted for rehabilitation often lack sufficient daytime blue light exposure due to the absence of natural light and are often exposed to light at unnatural time points. We hypothesized that artificial light imitating daylight, termed naturalistic light, would stabilize the circadian rhythm of plasma melatonin and serum cortisol levels among long-term hospitalized stroke patients. A quasi-randomized controlled trial. Read More

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http://dx.doi.org/10.7150/ijms.28863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332482PMC
January 2019

Robo 4 - the double-edged sword in prostate cancer: impact on cancer cell aggressiveness and tumor vasculature.

Int J Med Sci 2019 1;16(1):115-124. Epub 2019 Jan 1.

Department of Urology, Medical University Innsbruck, Austria.

The magic roundabout receptor 4 (Robo 4) is a tumor endothelial marker expressed in the vascular network of various tumor entities. However, the role of Robo 4 in prostate cancer (PCa), the second common cause of cancer death among men in -developed countries, has not been described yet. Thus, the present study investigates for the first time the impact of Robo 4 in PCa both in the clinical setting and . Read More

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http://dx.doi.org/10.7150/ijms.28735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332478PMC
January 2019
5 Reads

MicroRNA-320 targeting neuropilin 1 inhibits proliferation and migration of vascular smooth muscle cells and neointimal formation.

Int J Med Sci 2019 1;16(1):106-114. Epub 2019 Jan 1.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Jingan District, Shanghai, People's Republic of China.

This study shows that microRNA-320 (miR-320) is associated with many important cell functions, including cell differentiation, proliferation, migration, and apoptosis. However, the role of miR-320 in vascular smooth muscle cells (VSMCs) and proliferative vascular diseases is still completely unclear. In our study, we found that the expression of miR-320 in human VSMCs after PDGF stimulation was significantly down-regulated in time- and dose-dependent manner. Read More

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http://dx.doi.org/10.7150/ijms.28093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332474PMC
January 2019

Deduction of Novel Genes Potentially Involved in Upper Tract Urothelial Carcinoma Using Next-Generation Sequencing and Bioinformatics Approaches.

Int J Med Sci 2019 1;16(1):93-105. Epub 2019 Jan 1.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Upper tract urothelial carcinoma (UTUC) is a relatively uncommon cancer worldwide, however it accounts for approximately 30% of urothelial cancer in the Taiwanese population. The aim of the current study is to identify differential molecular signatures and novel miRNA regulations in UTUC, using next-generation sequencing and bioinformatics approaches. Two pairs of UTUC tumor and non-tumor tissues were collected during surgical resection, and RNAs extracted for deep sequencing. Read More

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http://dx.doi.org/10.7150/ijms.29560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332486PMC
January 2019

Proteomic Study of a Parkinson's Disease Model of Undifferentiated SH-SY5Y Cells Induced by a Proteasome Inhibitor.

Int J Med Sci 2019 1;16(1):84-92. Epub 2019 Jan 1.

Departments of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, Jilin Province, China.

Parkinson's disease (PD) is one of the most common nervous system degenerative diseases. However, the etiology of this disease remains elusive. Here, a proteasome inhibitor (PSI)-induced undifferentiated SH-SY5Y PD model was established to analyze protein alterations through proteomic study. Read More

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http://dx.doi.org/10.7150/ijms.28595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332475PMC
January 2019
5 Reads

Ultrasound/Elastography techniques, lipidomic and blood markers compared to Magnetic Resonance Imaging in non-alcoholic fatty liver disease adults.

Int J Med Sci 2019 1;16(1):75-83. Epub 2019 Jan 1.

Department of Nutrition, Food Science and Physiology. Centre for Nutrition Research. School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.

Introduction: Non-alcoholic fatty liver disease (NAFLD) may progress to steatohepatitis, cirrhosis and complicated hepatocellular carcinoma with defined differential symptoms and manifestations.

Objective: To evaluate the fatty liver status by several validated approaches and to compare imaging techniques, lipidomic and routine blood markers with magnetic resonance imaging in adults subjects with non-alcoholic fatty liver disease.

Materials And Methods: A total of 127 overweight/obese with NAFLD, were parallelly assessed by Magnetic Resonance Imaging (MRI), ultrasonography, transient elastography and a validated metabolomic designed test to diagnose NAFLD in this cross-sectional study. Read More

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http://www.medsci.org/v16p0075.htm
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http://dx.doi.org/10.7150/ijms.28044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332481PMC
January 2019
4 Reads

MEOX1 Promotes Tumor Progression and Predicts Poor Prognosis in Human Non-Small-Cell Lung Cancer.

Int J Med Sci 2019 1;16(1):68-74. Epub 2019 Jan 1.

Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109.

MEOX1 is a homeobox transcriptional factor, and plays essential roles in regulating somite development. Our previous study indicated that MEOX1 is a critical molecular target in mesenchymal-like cancer cells in PTEN-deficient Trastuzumab resistant breast cancer. Despite the potential implication of MEOX1 for the cancer progression, no previous studies examined its level and clinical significance in lung cancer tissues. Read More

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http://dx.doi.org/10.7150/ijms.27595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332485PMC
January 2019
1 Read
2.003 Impact Factor

A Novel Model for Studying Voltage-Gated Ion Channel Gene Expression during Reversible Ischemic Stroke.

Int J Med Sci 2019 1;16(1):60-67. Epub 2019 Jan 1.

Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan.

The dysfunction of voltage-gated ion channels contributes to the pathology of ischemic stroke. In this study, we developed rat models of transient ischemic attack (TIA) and reversible ischemic neurological deficit (RIND) that was induced via the injection of artificial embolic particles during full consciousness, that allow us to monitor the neurologic deficit and positron emission tomography (PET) scans in real-time. We then evaluated the infarction volume of brain tissue was confirmed by 2,3,5-triphenyl tetrazolium chloride (TTC) staining, and gene expressions were evaluated by quantitative real-time PCR (qPCR). Read More

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http://dx.doi.org/10.7150/ijms.27442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332493PMC
January 2019

LncRNA SNHG6 promotes proliferation, invasion and migration in colorectal cancer cells by activating TGF-β/Smad signaling pathway via targeting UPF1 and inducing EMT via regulation of ZEB1.

Int J Med Sci 2019 1;16(1):51-59. Epub 2019 Jan 1.

Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, People's Republic of China.

Long noncoding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides in length. They drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, RNA and protein. Recent studies have identified numerous lncRNAs active in colorectal cancer (CRC). Read More

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http://dx.doi.org/10.7150/ijms.27359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332483PMC
January 2019
1 Read
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Extravascular compared to Intravascular Femoral Closure is Associated with Less Bleeding and Similar MACE after Percutaneous Coronary Intervention.

Int J Med Sci 2019 1;16(1):43-50. Epub 2019 Jan 1.

First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, European Center for AngioScience (ECAS), and DZHK (German Center for Cardiovascular Research) partner site Heidelberg/Mannheim, Mannheim, Germany.

Various types of vascular closure devices (VCDs) are frequently utilized in patients undergoing percutaneous coronary intervention (PCI) in order to prevent arterial access site bleeding, which represents one of the most relevant complications associated with adverse clinical outcomes. This study aims to compare directly two mechanistically different types of femoral closure (FC) devices in patients undergoing PCI. This single-center, prospective, observational study includes consecutively patients either treated by the extravascular StarClose SE® (Abbott, Illinois, U. Read More

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http://www.medsci.org/v16p0043.htm
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http://dx.doi.org/10.7150/ijms.29253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332477PMC
January 2019
4 Reads
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Complete Disaggregation of MCF-7-derived Breast Tumour Spheroids with Very Low Concentrations of α-Mangostin Loaded in CD44 Thioaptamer-tagged Nanoparticles.

Int J Med Sci 2019 1;16(1):33-42. Epub 2019 Jan 1.

Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.

α-Mangostin (αMG) is a natural substance that exerts a wide range of antitumor effects. Recently, we described that free αMG was able to dissociate multicellular tumour spheroids (MCTSs) generated from breast carcinoma cells and to reduce their cellular viability and motility. Here, αMG was encapsulated into lipidic nanoparticles (NPs), conjugated or not to a CD44 thioaptamer, and the anticancer action evaluated against MCF-7 breast MCTSs. Read More

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http://dx.doi.org/10.7150/ijms.28135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332479PMC
January 2019

Nitrogen Containing Bisphosphonates Impair the Release of Bone Homeostasis Mediators and Matrix Production by Human Primary Pre-Osteoblasts.

Int J Med Sci 2019 1;16(1):23-32. Epub 2019 Jan 1.

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

Bisphosphonates (BPs) represent the first-line treatment for a wide array of bone disorders. Despite their well-known action on osteoclasts, the effects they induce on osteoblasts are still unclear. In order to shed light on this aspect we evaluated the impact of two nitrogen containing bisphosphonates, Alendronate (ALN) and Zoledronate (ZOL), on human primary pre-osteoblasts. Read More

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http://dx.doi.org/10.7150/ijms.27470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332484PMC
January 2019

Switching Lamivudine with Adefovir Dipivoxil Combination Therapy to Entecavir Monotherapy Provides Better Viral Suppression and Kidney Safety.

Int J Med Sci 2019 1;16(1):17-22. Epub 2019 Jan 1.

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University. Hangzhou 310003, China.

Most chronic hepatitis B (CHB) patients in China are primitively treated with a combination of lamivudine (LAM) and adefovir dipivoxil (ADV). Although antiviral resistance can be avoided with this combination therapy, using it can have harmful side effects related to ADV, specifically kidney and bone injury. This study was designed to compare viral suppression and kidney safety when switching LAM and ADV combination therapy to entecavir (ETV) monotherapy in patients with CHB and compensated hepatic cirrhosis. Read More

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http://dx.doi.org/10.7150/ijms.28700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332476PMC
January 2019
2 Reads

Protective Effect of Baicalein on Oxidative Stress-induced DNA Damage and Apoptosis in RT4-D6P2T Schwann Cells.

Int J Med Sci 2019 1;16(1):8-16. Epub 2019 Jan 1.

Anti-Aging Research Center, Dong-eui University, Busan 47340, Republic of Korea.

Due to its high antioxidant activity, baicalein, a kind of flavonoid present in Radical Scutellariae, has various pharmacological effects. However, the protective effect against oxidative stress in Schwann cells, which plays an important role in peripheral neuropathy, has not yet been studied. In this study, the effects of baicalein on hydrogen peroxide (HO)-induced DNA damage and apoptosis in RT4-D6P2T Schwann cells were evaluated. Read More

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http://dx.doi.org/10.7150/ijms.29692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332490PMC
January 2019
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Influence of Glucose Dosage in Parenteral Nutrition on Body Thiamine Levels in Rats.

Int J Med Sci 2019 1;16(1):1-7. Epub 2019 Jan 1.

PMM Group, Sales Division, Otsuka Pharmaceutical Factory, 2-9 Kanda Tsukasamachi, Chiyoda-ku, Tokyo 101-0048, Japan.

The objective of this study was to determine the relationship between glucose dosage in parenteral nutrition and reductions in levels of body thiamine in rats. Vitamin-free infusions with differing amounts of glucose were administered to normal or thiamine-deficient rats for 5 days, after which urinary thiamine excretion and the amounts of thiamine in the blood, liver, brain, and skeletal muscles were measured. The total energy dosage was set at three levels (98, 140, and 196 kcal/kg), and the dose of amino acids was constant among all groups. Read More

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http://www.medsci.org/v16p0001.htm
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http://dx.doi.org/10.7150/ijms.28756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332491PMC
January 2019
4 Reads

No Evidence for Lower Levels of Serum Vitamin D in the Presence of Hepatic Steatosis. A Study on the Portuguese General Population.

Int J Med Sci 2018 29;15(14):1778-1786. Epub 2018 Nov 29.

Serviço de Gastroenterologia, Hospital de Santa Maria, Laboratório de Nutrição, Faculdade de Medicina, Universidade de Lisboa, Portugal, Av. Prof. Egas Moniz, 1649-035 Lisboa, Portugal.

Nonalcoholic fatty liver disease (NAFLD) has become highly prevalent, paralleling the pandemic of obesity and diabetes, and represents an important burden. Nutrition knowledge is fundamental, in prevention, evolution and treatment of NAFLD. Association of low serum levels of vitamin D (VD) with several diseases, including NAFLD, has been emphasized in the last decade. Read More

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http://www.medsci.org/v15p1778.htm
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http://dx.doi.org/10.7150/ijms.26586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299420PMC
November 2018
3 Reads

Development of a Model for the Prediction of Treatment Response of Uterine Leiomyomas after Uterine Artery Embolization.

Int J Med Sci 2018 23;15(14):1771-1777. Epub 2018 Nov 23.

Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Uterine artery embolization (UAE) is one of the minimally-invasive alternatives to hysterectomy for treatment of uterine leiomyomas. There are various factors affecting the outcomes of UAE, but these have only been sporadically studied. To identify factors associated with the efficacy of UAE for the treatment of uterine leiomyoma, and to develop a model for the prediction of treatment response of uterine leiomyomas to UAE. Read More

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http://dx.doi.org/10.7150/ijms.28687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299417PMC
November 2018
6 Reads

Effectiveness of Eccentric Exercise and a Vibration or Cryotherapy Program in Enhancing Rectus Abdominis Muscle Thickness and Inter-Rectus Distance in Patients with Chronic Mid-Portion Achilles Tendinopathy: A Randomized Clinical Trial.

Int J Med Sci 2018 23;15(14):1764-1770. Epub 2018 Nov 23.

Faculty of Sport, Universidad Europea, Villaviciosa de Odón, Madrid, Spain.

: Abdominal muscles are key in maintaining body stability and balance and an improvement in the functioning of these muscles could influence the rehabilitation process in lower limb pathologies such as Achilles Tendinopathy (AT). The aim was to explore whether calf eccentric exercise (EE) with vibration training was more effective at causing adaptation to the rectus anterior (RA) thickness and inter-rectus distance (IRD) than calf EE with cryotherapy. : The investigation was a single-blinded, randomized, controlled clinical trial (NCT03515148). Read More

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http://dx.doi.org/10.7150/ijms.28656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299416PMC
November 2018
3 Reads

An Increased Neutrophil-to-Lymphocyte Ratio Predicts Incomplete Response to Therapy in Differentiated Thyroid Cancer.

Int J Med Sci 2018 23;15(14):1757-1763. Epub 2018 Nov 23.

Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.

: Previously we have shown that an elevated baseline neutrophil-to-lymphocyte ratio (NLR) was associated with a high risk of recurrence in patients with differentiated thyroid cancer. The clinical significance of the longitudinal changes in NLR following treatment remained unestablished. : Adults patients with differentiated thyroid cancer were included in the study if the follow-up NLR data at 6 to 18 months after initial treatment were available. Read More

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http://www.medsci.org/v15p1757.htm
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http://dx.doi.org/10.7150/ijms.28498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299424PMC
November 2018
1 Read

The Prognostic Value of Cytokeratin and Sal-Like Protein 4 Expression in Hepatocellular Carcinoma and Intra-Hepatic Cholangiocarcinoma in Taiwan.

Int J Med Sci 2018 23;15(14):1746-1756. Epub 2018 Nov 23.

Department of Pathology, Chang Bing Show Chwan Memorial Hospital, Changhua County 505, Taiwan.

We previously reported that modulation of cytokeratin18 induces pleomorphism of liver cells, higher cell motility, and higher drug sensitivity to sorafenib treatment of hepatoma cells. These relationships were established by experiments. The aim of this study was to determine the association between cytokeratin expression and tumor behavior, as well as cancer stem cells of hepatocellular carcinoma and intra-hepatic cholangiocarcinoma in Taiwan. Read More

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http://dx.doi.org/10.7150/ijms.28440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299409PMC
November 2018
2 Reads

Pathophysiologic Implications of Cytokines Secretion during Liver Transplantation Surgery.

Int J Med Sci 2018 23;15(14):1737-1745. Epub 2018 Nov 23.

Department of Anesthesiology and Pain Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea.

We introduce the following issues of the cytokines secretion during liver transplantation surgery in this review article; 1) the aspect of cytokines secretion during liver transplantation surgery, 2) the evidences of association of cytokines concentration with post-transplantation graft survival, 3) a variety of factors that may influence the secretion of cytokines during liver transplantation, 4) pro-inflammatory and anti-inflammatory cytokine balance during the surgery, and 5) the issues of T helper 1 and T helper 2, and T helper 17 and regulatory T cell signature cytokines secretion and their ratio during liver transplantation surgery. Primary failure of the liver is associated with the secondary dysfunction of virtually all other organ systems, including the cardiovascular, pulmonary, renal, coagulation and central nervous systems. In addition, liver transplantation surgery itself is a major surgical procedure with accompanying life-threatening hemorrhage, massive transfusion, clamping and unclamping of great vessels and resulting ischemia-reperfusion injury and cardiovascular instability. Read More

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http://dx.doi.org/10.7150/ijms.28382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299421PMC
November 2018
2 Reads

Effect of Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathological Characteristics.

Int J Med Sci 2018 22;15(14):1731-1736. Epub 2018 Nov 22.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

The high mobility group box 1 gene () plays a prominent role in cancer progression, angiogenesis, invasion, and metastasis. This study explored the effect of polymorphisms on clinicopathological characteristics of urothelial cell carcinoma (UCC). In total, 1293 participants (431 patients with UCC and 862 healthy controls) were recruited. Read More

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http://dx.doi.org/10.7150/ijms.27901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299401PMC
November 2018
1 Read
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Significance of PD-L1 Expression in Tongue Cancer Development.

Int J Med Sci 2018 22;15(14):1723-1730. Epub 2018 Nov 22.

Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan.

: Immunohistochemistry of PD-L1 has been recently established as a surrogate method to predict if immunotherapy targeting PD-L1/PD-1 has a significant effect on suppression of cancers such as lung non-small cell carcinoma, melanoma, and renal cell carcinoma. Here we performed immunohistochemistry for PD-L1 expression in squamous cell carcinoma (SCC) of the tongue to investigate the potential correlation between PD-L1 expression and clinicopathological factors and whether PD-L1 expression would be associated with prognosis. Tissue microarray cores of paraffin-embedded blocks from 135 cases with surgically resected tongue SCC were immunohistochemically analysed for PD-L1 expression. Read More

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http://www.medsci.org/v15p1723.htm
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http://dx.doi.org/10.7150/ijms.27860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299404PMC
November 2018
13 Reads

Elevated Tumor Necrosis Factor-a-induced Protein 8-like 2 mRNA from Peripheral Blood Mononuclear Cells in Patients with Acute Ischemic Stroke.

Int J Med Sci 2018 22;15(14):1713-1722. Epub 2018 Nov 22.

Department of Neurology, Jinan Central Hospital affiliated to Shandong University, Jinan 250013, China.

Tumor necrosis factor-a-induced protein 8-like 2 (TIPE2) is a novel regulator of immunity and protects against experimental stroke. However, the expression and function of TIPE2 in patients with acute ischemic stroke has not been well demonstrated. A total of 182 consecutive patients with acute ischemic stroke and 40 healthy controls were included during November 2015 to June 2016. Read More

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http://dx.doi.org/10.7150/ijms.27817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299423PMC
November 2018

Cancer/testis Antigen MAGEA3 Interacts with STAT1 and Remodels the Tumor Microenvironment.

Int J Med Sci 2018 22;15(14):1702-1712. Epub 2018 Nov 22.

Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

Cancer-testis antigen MAGEA3, being restrictedly expressed in testis and various kinds of tumors, has long been considered as an ideal target for immunotherapy. In this study, we report that MAGEA3 interacts with STAT1 and regulates the expression of tyrosine phosphorylated STAT1 (pY-STAT1) in tumor cells. We show that pY-STAT1 is significantly up-regulated when MAGEA3 is silenced by MAGEA3-specific siRNA. Read More

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http://www.medsci.org/v15p1702.htm
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http://dx.doi.org/10.7150/ijms.27643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299422PMC
November 2018
10 Reads