1,608 results match your criteria International journal of medical sciences[Journal]


A 3D Printed Porous Titanium Alloy Rod with Diamond Crystal Lattice for Treatment of the Early-Stage Femoral Head Osteonecrosis in Sheep.

Int J Med Sci 2019 9;16(3):486-493. Epub 2019 Mar 9.

Department of Orthopaedics, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China.

Instruments made of porous titanium alloy and fabricated with a 3D printed technique are increasingly used in experimental and clinical research. To date, however, few studies have assessed their use in early-stage osteonecrosis of the femoral head (ONFH). In this study, porous titanium alloy rods (Ti-Rod) with diamond crystal lattice, fabricated using an electron beam melting (EBM) technique, were implanted into sheep models (n=9) of early-stage ONFH for 6 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.30832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428983PMC
March 2019
1 Read

Airway Microbiome in Different Inflammatory Phenotypes of Asthma: A Cross-Sectional Study in Northeast China.

Int J Med Sci 2019 9;16(3):477-485. Epub 2019 Mar 9.

Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun, China.

Asthma is a common respiratory disease with a high prevalence and morbidity that can seriously affect quality of life. Microbial colonization of the airway may participate in the pathogenesis of asthma, however the mechanisms involved have not been established. In the present study, we aimed to determine the composition of the microbiota in different asthmatic phenotypes from Northeast China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.29433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428974PMC
March 2019
1 Read

Hes3 Enhances the Malignant Phenotype of Lung Cancer through Upregulating Cyclin D1, Cyclin D3 and MMP7 Expression.

Int J Med Sci 2019 9;16(3):470-476. Epub 2019 Mar 9.

Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, 110001, Shenyang, China.

is a basic helix-loop-helix factor gene, which was found to be involved in neural cell differentiation. Expression and clinicopathological significance of Hes3 in non-small cell lung cancer was not clear. In this study, we used immunohistochemistry to examine Hes3 expression in normal human lung and non-small cell lung cancer tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.28139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428979PMC
March 2019
2 Reads

Glucocorticoid Regulates NLRP3 in Acute-On-Chronic Hepatitis B Liver Failure.

Int J Med Sci 2019 9;16(3):461-469. Epub 2019 Mar 9.

Department of Hepatology, Qilu Hospital of Shandong University, Jinan 250012, China.

Acute-on-chronic hepatitis B liver failure (ACHBLF) refers to the acute deterioration of liver function during chronic hepatitis B virus infection, and is associated with high mortality, with rapid progression to death. Nucleotide-binding oligomerisation domain-like receptors (NLRs) Family Pyrin Domain Containing 3(NLRP3) inflammasome contributed to the pathogenesis of D-galactosamine and lipopolysaccharide-induced acute liver failure. However, the profile of NLRP3 in patients with ACHBLF has not been demonstrated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.30424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428984PMC
March 2019
2 Reads

Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations.

Int J Med Sci 2019 28;16(3):450-460. Epub 2019 Feb 28.

Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Papillary thyroid cancer (PTC) is the most prevalent form of malignancy among all cancers of the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC is usually contained within the thyroid gland and generally biologically indolent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.29935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428975PMC
February 2019
1 Read
2.003 Impact Factor

Decreased Ambient Oxygen Tension Alters the Expression of Endothelin-1, iNOS and cGMP in Rat Alveolar Macrophages.

Int J Med Sci 2019 28;16(3):443-449. Epub 2019 Feb 28.

Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Hypoxia plays an important role in the vascular tone of pulmonary circulation via the vasculature and parenchymal tissue. Endothelin-1 (ET-1), a potent vasoconstrictive peptide, plays a role in inflammation in mononuclear cells. Nitric oxide synthase (NOS), which generates nitric oxide (NO)/cyclic 3', 5'-monophosphate (cGMP), is coexpressed with ET-1 in many cell types. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.28353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428981PMC
February 2019

Histone Deacetylases (HDACs) Guided Novel Therapies for T-cell lymphomas.

Int J Med Sci 2019 29;16(3):424-442. Epub 2019 Jan 29.

China Central Laboratory of Peking University Shenzhen Hospital, Shenzhen, Guangdong, 518036, China.

T-cell lymphomas are a heterogeneous group of cancers with different pathogenesis and poor prognosis. Histone deacetylases (HDACs) are epigenetic modifiers that modulate many key biological processes. In recent years, HDACs have been fully investigated for their roles and potential as drug targets in T-cell lymphomas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.30154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428980PMC
January 2019
7 Reads

Depletion of WNT10A Prevents Tumor Growth by Suppressing Microvessels and Collagen Expression.

Int J Med Sci 2019 29;16(3):416-423. Epub 2019 Jan 29.

Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.

: We recently reported that WNT10A plays a pivotal role in wound healing by regulating collagen expression/synthesis, as the depletion of WNT10A dramatically delays skin ulcer formation. WNT signaling also has a close correlation with the cancer microenvironment and proliferation, since tumors are actually considered to be 'unhealing' or 'overhealing' wounds. To ascertain the regulatory functions of WNT10A in tumor growth, we examined the net effects of WNT10A depletion using -deficient mice (). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.26997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428976PMC
January 2019
2.003 Impact Factor

Establishment of metastatic liver carcinoma model by implanting AX7 cells into rabbit liver, and its histological findings.

Int J Med Sci 2019 29;16(3):409-415. Epub 2019 Jan 29.

Division of Hepatobiliarypancreas and Transplantation, Department of Surgery, Pusan National University Hospital, Busan, Republic of Korea.

: Progression of metastatic liver carcinoma from any original cancer is aggressive and the prognosis is very poor. Therefore the new model that is easily approachable to study the propagation and prognosis of metastatic liver carcinoma is necessary. The aim of this study is to confirm the tumor formation and metastatic activity of anaplastic thyroid cancer and to support the research basis for the next generation cancer treatment that is to be developed, by carrying out additional experiments like cytokine stimulation. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v16p0409.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.28998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428987PMC
January 2019
4 Reads

Prognostic significance of serum soluble DR5 levels in small-cell lung cancer.

Int J Med Sci 2019 29;16(3):403-408. Epub 2019 Jan 29.

Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250014, China.

The death receptor 5 (DR5) is a member of the tumor necrosis factor receptor superfamily that can transduce the apoptosis signal in cells. This study assessed serum levels of soluble death receptor 5 (sDR5) in small-cell lung cancer (SCLC) patients compared with those in healthy controls. Clinicopathological features of patients, treatment responses, and overall survival of patients were also recorded and analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.28814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428977PMC
January 2019

Changes and Significance of SYP and GAP-43 Expression in the Hippocampus of CIH Rats.

Int J Med Sci 2019 29;16(3):394-402. Epub 2019 Jan 29.

Department of Neurology, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Zunyi, Guizhou, China, 563003.

Synaptophysin (SYP) and growth-associated binding protein 43 (GAP-43) have been shown to be closely related to hippocampal synaptic plasticity in recent years. They are important molecular markers associated with synaptic plasticity. However, the role of SYP and GAP-43 in chronic intermittent hypoxic injury of the central nervous system needs to be further clarified. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v16p0394.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.28359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428973PMC
January 2019
3 Reads

PM Upregulates MicroRNA-146a-3p and Induces M1 Polarization in RAW264.7 Cells by Targeting Sirtuin1.

Int J Med Sci 2019 29;16(3):384-393. Epub 2019 Jan 29.

Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing, China, 100034.

: Fine particulate matter (PM) exposure is proved to be associated with illnesses, but the mechanism is not clear. Potential effects of PM on innate immunity have become a hotspot recently. Confronting PM, macrophages are able to be activated and induce inflammatory responses. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v16p0384.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.30084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428978PMC
January 2019
2 Reads

Efficacy of Single-Dose Dexmedetomidine Combined with Low-Dose Remifentanil Infusion for Cough Suppression Compared to High-Dose Remifentanil Infusion: A Randomized, Controlled, Non-Inferiority Trial.

Int J Med Sci 2019 24;16(3):376-383. Epub 2019 Jan 24.

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.

Combination of dexmedetomidine and opioid may be an alternative to high-dose opioid in attenuating cough during emergence from anesthesia, while also reducing the adverse effects of high-dose opioid. We tested the hypothesis that a single-dose of dexmedetomidine combined with low-dose remifentanil infusion during emergence would not be inferior to high-dose remifentanil infusion alone in attenuating cough after thyroidectomy. One hundred sixty-nine patients undergoing thyroidectomy were enrolled and randomized in a 1:1 ratio into group DR or group R. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.30227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428982PMC
January 2019

New Insight on Solute Carrier Family 27 Member 6 (SLC27A6) in Tumoral and Non-Tumoral Breast Cells.

Int J Med Sci 2019 24;16(3):366-375. Epub 2019 Jan 24.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Long-chain fatty acids are the most abundant fatty acids and are essential for various physiological processes. Translocation of long-chain fatty acids across cell membrane is dependent on transport proteins. Solute carrier family 27 member 6 (SLC27A6) is a transport protein which mediates long-chain fatty acid uptake. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.29946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428986PMC
January 2019
2 Reads

The Conserved Molecular Determinants of Virulence in Dengue Virus.

Int J Med Sci 2019 24;16(3):355-365. Epub 2019 Jan 24.

Centre for Virus and Vaccine Research, School of Science and Technology, Sunway University, 47500 Subang Jaya, Selangor, Malaysia.

Dengue virus belongs to the Flaviviridae family which also includes viruses such as the Zika, West Nile and yellow fever virus. Dengue virus generally causes mild disease, however, more severe forms of the dengue virus infection, dengue haemorrhagic fever (DHF) and dengue haemorrhagic fever with shock syndrome (DSS) can also occur, resulting in multiple organ failure and even death, especially in children. The only dengue vaccine available in the market, CYD-TDV offers limited coverage for vaccinees from 9-45 years of age and is only recommended for individuals with prior dengue exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.29938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428985PMC
January 2019
2 Reads

Gene Expression Profiling in Ischemic Postconditioning to Alleviate Mouse Liver Ischemia/Reperfusion Injury.

Int J Med Sci 2019 24;16(2):343-354. Epub 2019 Jan 24.

Department of Transplant Surgery, The Third Xiangya Hospital of Central South University, Changsha 410013, China.

Ischemic postconditioning (IPO) attenuates hepatic ischemia/reperfusion (I/R) injury. However, little is known about the underlying biological pathophysiology, which could be, at least in part, informed by exploring the transcriptomic changes using next-generation RNA sequencing (RNA-Seq). In this study, 18 mice (C57BL/6) were involved and randomly assigned to three groups: normal (n=6), I/R (n=6, subjected to 70% hepatic I/R), and IR+IPO (n=6, applying IPO to mice with I/R injury). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.29393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367534PMC
January 2019

Association between Anaesthetic Technique and Oncological Outcomes after Colorectal Carcinoma Liver Metastasis Resection.

Int J Med Sci 2019 24;16(2):337-342. Epub 2019 Jan 24.

Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, 225 Changhai Road, Shanghai, China.

Recently published studies suggest that the anaesthetic technique used during oncologic surgery can improve patient outcomes. Therefore, the authors evaluated the survival of patients with resected colorectal carcinoma liver metastases (CRCLMs) who received either EGA (general anaesthesia [GA] combined with epidural anaesthesia [EA]) or GA alone. We conducted an ambispective cohort study including 225 post-surgical CRCLM patients between May 2007 and July 2012 and performed a follow-up investigation of survival in July 2017. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v16p0337.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.28016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367527PMC
January 2019
7 Reads

Correlation between genetic polymorphism of angiopoietin-2 gene and clinical aspects of rheumatoid arthritis.

Int J Med Sci 2019 1;16(2):331-336. Epub 2019 Jan 1.

Department of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.

The Angiopoietin-2 (Ang2) gene encodes angiogenic factor, and the polymorphisms of Ang2 gene predict risk of various human diseases. We want to investigate whether the single nucleotide polymorphisms (SNPs) of the Ang2 gene can predict the risk of rheumatoid arthritis (RA). Between 2016 and 2018, we recruited 335 RA patients and 700 control participants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.30582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367530PMC
January 2019
3 Reads
2.003 Impact Factor

A Pilot Study of Aberrant CpG Island Hypermethylation of in Acute Myeloloid Leukemia.

Int J Med Sci 2019 1;16(2):324-330. Epub 2019 Jan 1.

Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, China.

Epigenetic silencing of tumor suppressor genes plays important role in acute myeloid leukemia (AML). Recently, SPRED1, a negative regulator of the RAS MAPK pathway, is identified as a tumour suppressor downregulated in AML. However, little is known regarding its underlying dysregulation in AML. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.27757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367533PMC
January 2019
1 Read
2.003 Impact Factor

Systemic Angiopoietin-1/2 Dysregulation in Pediatric Sepsis and Septic Shock.

Int J Med Sci 2019 1;16(2):318-323. Epub 2019 Jan 1.

Department of Medicine, University of Washington, Seattle, WA.

Angiopoietin-1 and -2 are vascular growth factors that exert opposing effects on endothelial activation and dysfunction. The aim of this study was to assess the association of these biomarkers with outcomes in children with sepsis. Biomarkers were assayed from the blood collected in an emergency department prior to any intervention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.27731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367536PMC
January 2019
1 Read

Feasible Advantage of Bioactive/Bioresorbable Devices Made of Forged Composites of Hydroxyapatite Particles and Poly-L-lactide in Alveolar Bone Augmentation: A Preliminary Study.

Int J Med Sci 2019 1;16(2):311-317. Epub 2019 Jan 1.

Division of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Takamatsu, Japan.

: We aimed to document the clinical usefulness of uncalcined and unsintered hydroxyapatite (u-HA) particles and poly-L-lactide (PLLA) composite materials and their advantageous properties. : Between April 2016 and March 2018, five patients required anterior maxillary alveolar ridge augmentation using fixation with u-HA/PLLA screws for an onlay block bone graft harvested from the mandibular ramus at our institute. Bone biopsies were obtained from the dental implantation site following bone healing for histomorphometric and immunohistochemical (IHC) measurements. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.27986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367538PMC
January 2019

Imbalance of erythropoiesis and iron metabolism in patients with thalassemia.

Int J Med Sci 2019 1;16(2):302-310. Epub 2019 Jan 1.

Department of Hematology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

This study aimed to evaluate the imbalance of erythropoiesis and iron metabolism in patients with thalassemia. 192 patients with non-transfusion-dependent thalassemia (NTDT), 94 patients with transfusion-dependent thalassemia (TDT) and 101 healthy controls were recruited between June 2013 and December 2016 in the Hematology Department, the First Affiliated Hospital of Guangxi Medical University. The groups were compared in terms of levels of erythropoiesis biomarkers [growth differentiation factor 15 (GDF15), erythropoietin (EPO) and soluble transferrin receptor (sTfR)] and of iron overload biomarkers [serum ferritin (SF), liver iron concentration (LIC) and cardiac T2*] and hepcidin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.27829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367537PMC
January 2019
1 Read

Circular RNA: a novel biomarker and therapeutic target for human cancers.

Int J Med Sci 2019 1;16(2):292-301. Epub 2019 Jan 1.

Department of Pathophysiology, Third Military Medical University, Chongqing 400038, China.

Circular (circ)RNAs, a newly recognized class of noncoding RNA, have been implicated in the occurrence and development of several diseases, including neurological and cardiovascular diseases. Studies of human tumors, including those of liver cancer, gastric cancer, lung cancer and colorectal cancer, have shown differential expression profiles of circRNAs, suggesting regulatory roles in cancer pathogenesis and metastasis. In this review, we discuss the most recent research into tumor-related circRNAs, providing a comprehensive summary of the expression or/and function of these circRNAs and proposing rational perspectives on the potential clinical application of circRNAs as helpful biomarkers or therapeutic targets in human tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.28047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367529PMC
January 2019

Non-alcoholic fatty liver disease is associated with low-grade albuminuria in men without diabetes mellitus.

Int J Med Sci 2019 1;16(2):285-291. Epub 2019 Jan 1.

Division of Nephrology, Department of Internal Medicine, Yeungnam University Hospital, Daegu, Republic of Korea.

Non-alcoholic fatty liver disease (NAFLD) is associated with the dysregulation of multiple metabolic and inflammatory pathways. These can lead to extrahepatic disorders involving the kidney, a vulnerable organ responsible for extra-renal complications. Evaluating the association between NAFLD and low-grade albuminuria as a renal complication would be helpful to better understand the pathophysiology and extra-hepatic complications of NAFLD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.28264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367539PMC
January 2019
1 Read

Von Willebrand Factor Adhesive Activity and ADAMTS13 Protease Activity in HIV-1-Infected Men.

Int J Med Sci 2019 1;16(2):276-284. Epub 2019 Jan 1.

Department of Medicine, University of Washington, Seattle, WA USA.

Endothelial activation caused by HIV-1 infection leads to release of von Willebrand factor (VWF), which enters the circulation or attaches to vessel walls and self-assembles into strings and fibers, enabling platelet adhesion; this adhesive activity is regulated by the VWF-cleaving protease ADAMTS13. Our objective was to assess VWF adhesive activity and ADAMTS13 protease activity in HIV-1 infection. We measured levels of VWF antigen, VWF activation factor (a measure of adhesive activity), ADAMTS13 antigen, ADAMTS13 activity, and apolipoprotein A1 (which interferes with VWF self-association) in serum samples from HIV-1-infected men whose infections were acute (n=10), chronic untreated (n=10), or chronic treated (n=10), compared to uninfected controls (n=10). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.28110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367531PMC
January 2019
1 Read

Platelet Reactivity And Circulating Platelet-Derived Microvesicles Are Differently Affected By P2Y Receptor Antagonists.

Int J Med Sci 2019 1;16(2):264-275. Epub 2019 Jan 1.

Second Department of Cardiology, Jagiellonian University Medical College, Cracow, Poland.

: Platelet-derived microvesicles (PMVs), shed from platelet surface membranes, constitute the majority of circulating microvesicles and have been implicated in procoagulant, pro-inflammatory and pro-atherosclerotic effects. Our aim was to compare plasma PMVs numbers in relation to platelet reactivity during dual antiplatelet therapy (DAPT) with various P2Y adenosine diphosphate (ADP) receptor antagonists. In pre-discharge men treated with DAPT for an acute coronary syndrome, plasma PMVs were quantified by flow cytometry on the basis of CD62P (P-selectin) and CD42 (glycoprotein Ib) positivity, putative indices of PMVs release from activated and all platelets, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.28580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367525PMC
January 2019
2 Reads

Temporomandibular Disorders and Oral Features in Early Rheumatoid Arthritis Patients: An Observational Study.

Int J Med Sci 2019 1;16(2):253-263. Epub 2019 Jan 1.

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, "Aldo Moro" University of Bari, Italy.

Temporomandibular disorders (TMD) represent a heterogeneous group of inflammatory or degenerative diseases of the stomatognatic system, with algic and/or dysfunctional clinical features involving temporomandibular joint (TMJ) and related masticatory muscles. Rheumatoid Arthritis (RA) is an autoimmune polyarthritis characterized by the chronic inflammation of synovial joints and oral implications such as hyposalivation, difficulty in swallowing and phoning, feeling of burning mouth, increased thirst, loss of taste or unpleasant taste and smell, dental sensitivity. The aim of this observational study was to investigate the prevalence of TMD symptoms and signs as well as oral implications in patients with Early Rheumatoid Arthritis (ERA), that is a RA diagnosed within 12 months, compared with a control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.28361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367523PMC
January 2019
2 Reads

Reliability of Preoperative Inguinal Sonography for Evaluating Patency of Processus Vaginalis in Pediatric Inguinal Hernia Patients.

Int J Med Sci 2019 1;16(2):247-252. Epub 2019 Jan 1.

Department of Surgery, Konkuk University Chungju Hospital, Chungju, Republic of Korea.

: Among childhood illnesses requiring surgery, inguinal hernia is the most common entity. Pediatric inguinal hernia has been traditionally operated through a small incision in the inguinal region. Contralateral metachronous inguinal hernia has been the topic of discussion in pediatric surgeon's domain for a long time. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v16p0247.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.28730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367528PMC
January 2019
11 Reads

MUC7 Level As A New Saliva Risk Factor For Dental Caries In Adult Patients.

Int J Med Sci 2019 1;16(2):241-246. Epub 2019 Jan 1.

Department of Medical Microbiology, University of Medical Sciences in Poznan, Poland.

: Data currently available indicate the significance of salivary mucins MUC5B and MUC7 in the protection of teeth against caries. Our study aimed to determine the relationship between dental caries in adults and levels of MUC5B and MUC7. : The studies were conducted on 45 adult subjects selected on the basis of dental examination and calculation of the DMFT (Decayed, Missing, and Filled Teeth) index. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.29027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367524PMC
January 2019
1 Read

Anti-proliferative and Anti-invasive Effect of Polysaccharide-rich Extracts from in Colon Cancer Cells.

Int J Med Sci 2019 1;16(2):231-240. Epub 2019 Jan 1.

Epithelial Plasticity and Metastasis Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC).

Colorectal cancer (CRC) is one of leading causes of mortality in western countries and novel treatment strategies are required. The medicinal application of mushrooms has been used in traditional medicine in many oriental countries. Polysaccharide-rich extracts obtained from certain medicinal mushroom species have shown antitumor effects in different experimental models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.28811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367522PMC
January 2019

A New Look at Causal Factors of Idiopathic Scoliosis: Altered Expression of Genes Controlling Chondroitin Sulfate Sulfation and Corresponding Changes in Protein Synthesis in Vertebral Body Growth Plates.

Int J Med Sci 2019 1;16(2):221-230. Epub 2019 Jan 1.

University of Pittsburgh, Pittsburgh PA, USA.

In a previous report, we demonstrated the presence of cells with a neural/glial phenotype on the concave side of the vertebral body growth plate in Idiopathic Scoliosis (IS) and proposed this phenotype alteration as the main etiological factor of IS. In the present study, we utilized the same specimens of vertebral body growth plates removed during surgery for Grade III-IV IS to analyse gene expression. We suggested that phenotype changes observed on the concave side of the vertebral body growth plate can be associated with altered expression of particular genes, which in turn compromise mechanical properties of the concave side. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.29312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367535PMC
January 2019
1 Read

MicroRNA-29a is a key regulon that regulates BRD4 and mitigates liver fibrosis in mice by inhibiting hepatic stellate cell activation.

Int J Med Sci 2019 1;16(2):212-220. Epub 2019 Jan 1.

Core Laboratory for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, 833.

MicroRNA-29a is a key regulon that regulates hepatic stellate cells (HSCs) and mitigates liver fibrosis. However, the mechanism by which it does so remains largely undefined. The inhibition of bromodomain-4 protein (BRD4) represents a novel therapeutic target in hepatic fibrosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.29930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367521PMC
January 2019

Current status of endovascular treatment for dural arteriovenous fistulae in the anterior cranial fossa: A systematic literature review.

Int J Med Sci 2019 1;16(2):203-211. Epub 2019 Jan 1.

Department of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.

Anterior cranial fossa (ACF) dural arteriovenous fistulae (DAVFs) are rare, and a systematic review of the literature is lacking. Such a review is necessary, however, so a systematic PubMed search of related studies was performed. Twenty-four studies were identified, reporting on 48 patients, of whom 39 had definite age and sex information and 33 (84. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.29637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367520PMC
January 2019
1 Read

Retardation of Myopia Progression by Multifocal Soft Contact Lenses.

Int J Med Sci 2019 1;16(2):198-202. Epub 2019 Jan 1.

Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University (the Second People's Hospital of Yunnan Province); Yunnan Eye Institute; Key Laboratory of Yunnan Province for the Prevention and Treatment of ophthalmology (2017DG008); Provincial Innovation Team for Cataract and Ocular Fundus Disease, The Second People's Hospital of Yunnan Province (2017HC010); Expert Workstation of Yao Ke (2017IC064), Kunming 650021, China.

Myopia is an important public health problem due to its prevalence and significant public health cost. Elevating levels of myopia increase the risk of vision impairment, and therefore, high myopia has become one of the main causes of untreatable vision loss throughout the world due to its irreversible complications. At present, many options for slowing progression of myopia have already been proposed and evaluated such as progressive addition of executive bifocal spectacle lenses, peripheral defocusing lenses, overnight orthokeratology, pharmacological agents such as atropine eye drops, and multifocal soft contact lenses (MFSCLs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.30118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367526PMC
January 2019
5 Reads

Antarctic freshwater microalga, , suppresses inflammation and carcinogenesis.

Int J Med Sci 2019 1;16(2):189-197. Epub 2019 Jan 1.

Division of Polar Life Sciences, Korea Polar Research Institute, Incheon, 21990, Republic of Korea.

Inflammation triggered by the innate immune system is a strategy to protect organisms from the risk of environmental infection. However, it has recently become clear that inflammation can cause a variety of human diseases, including cancer. In this study, we investigated the effects of an ethanol extract of the Antarctic freshwater microalgae, (ETCH), on inflammation and carcinogenesis in RAW 264. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.30647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367532PMC
January 2019

Nonselective Cyclooxygenase Inhibition Retards Cyst Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease.

Int J Med Sci 2019 1;16(1):180-188. Epub 2019 Jan 1.

Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.

Autosomal dominant polycystic kidney disease is one of the most common genetic renal diseases. Cyclooxygenase plays an important role in epithelial cell proliferation and may contribute to the mechanisms underlying cyst formation. The aim of the present study was to evaluate the role of cyclooxygenase inhibition in the cyst progression in polycystic kidney disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.27719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332488PMC
April 2019
8 Reads

Lipopolysaccharide promoted proliferation and adipogenesis of preadipocytes through JAK/STAT and AMPK-regulated cPLA2 expression.

Int J Med Sci 2019 1;16(1):167-179. Epub 2019 Jan 1.

Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan.

The proliferation and adipogenesis of preadipocytes played important roles in the development of adipose tissue and contributed much to the processes of obesity. On the other hand, lipopolysaccharide (LPS), also known as endotoxin, is a key outer membrane component of gram-negative bacteria in the gut microbiota, and has a dominant role in linking inflammation to high-fat diet-induced metabolic syndrome. Studies suggested the potential roles of LPS in hepatic steatosis and in obese mice models. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v16p0167.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.24068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332489PMC
April 2019
4 Reads
2.003 Impact Factor

Shockwave Targeting on Subchondral Bone Is More Suitable than Articular Cartilage for Knee Osteoarthritis.

Int J Med Sci 2019 1;16(1):156-166. Epub 2019 Jan 1.

Section of Sports Medicine, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Our study compared the effects of extracorporeal shockwave therapy (ESWT) on the subchondral bone and the articular cartilage in the treatment of early osteoarthritis (OA) of rat knee. The rats were divided into 5 groups which included Sham group, Meniscus group (ESWT applied on medial meniscus), OA group (arthrotomy and medial menisectomy (MMx) and anterior cruciate ligament transection (ACLT), T(M) group (arthrotomy and MMx and ACLT followed by ESWT on medial tibial subchondral bone) and Articular cartilage group (arthrotomy and MMx and ACLT followed by ESWT on medial articular cartilage). Evaluations included the pathological changes of the synovium, articular cartilage and subchondral bone, and compared with ESWT on the meniscus, medial tibial subchondral bone and articular cartilage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.26659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332487PMC
April 2019
7 Reads

Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of baicalein against oxidative stress-induced DNA damage and apoptosis in HEI193 Schwann cells.

Int J Med Sci 2019 1;16(1):145-155. Epub 2019 Jan 1.

Anti-Aging Research Center and Department of Biochemistry, Dongeui University College of Korean Medicine, Busan 47227, Republic of Korea.

Baicalein, a flavonoid extracted from the roots of Georgi., has various pharmacological effects due to its high antioxidant activity. However, no study has yet been conducted on the protective efficacy of baicalein against oxidative stress in Schwann cells. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v16p0145.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.27005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332480PMC
April 2019
14 Reads

Bilirubin Attenuates ER Stress-Mediated Inflammation, Escalates Apoptosis and Reduces Proliferation in the LS174T Colonic Epithelial Cell Line.

Int J Med Sci 2019 1;16(1):135-144. Epub 2019 Jan 1.

School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.

Mildly elevated serum unconjugated bilirubin (UCB) concentrations are associated with protection against disease conditions underpinned by cellular and metabolic stress. To determine the potential therapeutic efficacy of UCB we tested it in an model of gut inflammation. Tunicamycin TUN (10 µg/mL) was used to induce endoplasmic reticular stress (ERS) affecting N-glycosylation in LS174T cells. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v16p0135.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.29134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332492PMC
April 2019
14 Reads
2.003 Impact Factor

The Effects of Naturalistic Light on Diurnal Plasma Melatonin and Serum Cortisol Levels in Stroke Patients during Admission for Rehabilitation: A Randomized Controlled Trial.

Int J Med Sci 2019 1;16(1):125-134. Epub 2019 Jan 1.

Clinical Stroke Research Unit, Department of Neurology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen.

Stroke patients admitted for rehabilitation often lack sufficient daytime blue light exposure due to the absence of natural light and are often exposed to light at unnatural time points. We hypothesized that artificial light imitating daylight, termed naturalistic light, would stabilize the circadian rhythm of plasma melatonin and serum cortisol levels among long-term hospitalized stroke patients. A quasi-randomized controlled trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.28863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332482PMC
April 2019
1 Read

Robo 4 - the double-edged sword in prostate cancer: impact on cancer cell aggressiveness and tumor vasculature.

Int J Med Sci 2019 1;16(1):115-124. Epub 2019 Jan 1.

Department of Urology, Medical University Innsbruck, Austria.

The magic roundabout receptor 4 (Robo 4) is a tumor endothelial marker expressed in the vascular network of various tumor entities. However, the role of Robo 4 in prostate cancer (PCa), the second common cause of cancer death among men in -developed countries, has not been described yet. Thus, the present study investigates for the first time the impact of Robo 4 in PCa both in the clinical setting and . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.28735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332478PMC
April 2019
17 Reads

MicroRNA-320 targeting neuropilin 1 inhibits proliferation and migration of vascular smooth muscle cells and neointimal formation.

Int J Med Sci 2019 1;16(1):106-114. Epub 2019 Jan 1.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Jingan District, Shanghai, People's Republic of China.

This study shows that microRNA-320 (miR-320) is associated with many important cell functions, including cell differentiation, proliferation, migration, and apoptosis. However, the role of miR-320 in vascular smooth muscle cells (VSMCs) and proliferative vascular diseases is still completely unclear. In our study, we found that the expression of miR-320 in human VSMCs after PDGF stimulation was significantly down-regulated in time- and dose-dependent manner. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v16p0106.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.28093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332474PMC
April 2019
6 Reads

Deduction of Novel Genes Potentially Involved in Upper Tract Urothelial Carcinoma Using Next-Generation Sequencing and Bioinformatics Approaches.

Int J Med Sci 2019 1;16(1):93-105. Epub 2019 Jan 1.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Upper tract urothelial carcinoma (UTUC) is a relatively uncommon cancer worldwide, however it accounts for approximately 30% of urothelial cancer in the Taiwanese population. The aim of the current study is to identify differential molecular signatures and novel miRNA regulations in UTUC, using next-generation sequencing and bioinformatics approaches. Two pairs of UTUC tumor and non-tumor tissues were collected during surgical resection, and RNAs extracted for deep sequencing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.29560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332486PMC
April 2019
2 Reads

Proteomic Study of a Parkinson's Disease Model of Undifferentiated SH-SY5Y Cells Induced by a Proteasome Inhibitor.

Int J Med Sci 2019 1;16(1):84-92. Epub 2019 Jan 1.

Departments of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, Jilin Province, China.

Parkinson's disease (PD) is one of the most common nervous system degenerative diseases. However, the etiology of this disease remains elusive. Here, a proteasome inhibitor (PSI)-induced undifferentiated SH-SY5Y PD model was established to analyze protein alterations through proteomic study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.28595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332475PMC
April 2019
13 Reads

Ultrasound/Elastography techniques, lipidomic and blood markers compared to Magnetic Resonance Imaging in non-alcoholic fatty liver disease adults.

Int J Med Sci 2019 1;16(1):75-83. Epub 2019 Jan 1.

Department of Nutrition, Food Science and Physiology. Centre for Nutrition Research. School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.

Introduction: Non-alcoholic fatty liver disease (NAFLD) may progress to steatohepatitis, cirrhosis and complicated hepatocellular carcinoma with defined differential symptoms and manifestations.

Objective: To evaluate the fatty liver status by several validated approaches and to compare imaging techniques, lipidomic and routine blood markers with magnetic resonance imaging in adults subjects with non-alcoholic fatty liver disease.

Materials And Methods: A total of 127 overweight/obese with NAFLD, were parallelly assessed by Magnetic Resonance Imaging (MRI), ultrasonography, transient elastography and a validated metabolomic designed test to diagnose NAFLD in this cross-sectional study. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v16p0075.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.28044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332481PMC
April 2019
6 Reads

MEOX1 Promotes Tumor Progression and Predicts Poor Prognosis in Human Non-Small-Cell Lung Cancer.

Int J Med Sci 2019 1;16(1):68-74. Epub 2019 Jan 1.

Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109.

MEOX1 is a homeobox transcriptional factor, and plays essential roles in regulating somite development. Our previous study indicated that MEOX1 is a critical molecular target in mesenchymal-like cancer cells in PTEN-deficient Trastuzumab resistant breast cancer. Despite the potential implication of MEOX1 for the cancer progression, no previous studies examined its level and clinical significance in lung cancer tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.27595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332485PMC
April 2019
2 Reads
2.003 Impact Factor

A Novel Model for Studying Voltage-Gated Ion Channel Gene Expression during Reversible Ischemic Stroke.

Int J Med Sci 2019 1;16(1):60-67. Epub 2019 Jan 1.

Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan.

The dysfunction of voltage-gated ion channels contributes to the pathology of ischemic stroke. In this study, we developed rat models of transient ischemic attack (TIA) and reversible ischemic neurological deficit (RIND) that was induced via the injection of artificial embolic particles during full consciousness, that allow us to monitor the neurologic deficit and positron emission tomography (PET) scans in real-time. We then evaluated the infarction volume of brain tissue was confirmed by 2,3,5-triphenyl tetrazolium chloride (TTC) staining, and gene expressions were evaluated by quantitative real-time PCR (qPCR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.27442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332493PMC
April 2019
1 Read

LncRNA SNHG6 promotes proliferation, invasion and migration in colorectal cancer cells by activating TGF-β/Smad signaling pathway via targeting UPF1 and inducing EMT via regulation of ZEB1.

Int J Med Sci 2019 1;16(1):51-59. Epub 2019 Jan 1.

Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, People's Republic of China.

Long noncoding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides in length. They drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, RNA and protein. Recent studies have identified numerous lncRNAs active in colorectal cancer (CRC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.27359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332483PMC
April 2019
1 Read
2.003 Impact Factor

Extravascular compared to Intravascular Femoral Closure is Associated with Less Bleeding and Similar MACE after Percutaneous Coronary Intervention.

Int J Med Sci 2019 1;16(1):43-50. Epub 2019 Jan 1.

First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, European Center for AngioScience (ECAS), and DZHK (German Center for Cardiovascular Research) partner site Heidelberg/Mannheim, Mannheim, Germany.

Various types of vascular closure devices (VCDs) are frequently utilized in patients undergoing percutaneous coronary intervention (PCI) in order to prevent arterial access site bleeding, which represents one of the most relevant complications associated with adverse clinical outcomes. This study aims to compare directly two mechanistically different types of femoral closure (FC) devices in patients undergoing PCI. This single-center, prospective, observational study includes consecutively patients either treated by the extravascular StarClose SE® (Abbott, Illinois, U. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v16p0043.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.29253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332477PMC
April 2019
11 Reads
2.003 Impact Factor