207 results match your criteria International journal of gastrointestinal cancer[Journal]


Dermatofibrosarcoma protuberans and small bowel adenocarcinoma: coincidental occurrence or genetic association?

Int J Gastrointest Cancer 2006 ;37(4):146-8

Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

A case of multiple malignancies in a 41 year old African American man is described. After surgical excision and radiotherapy of dermatofibrosarcoma protuberans, the patient developed small bowel adenocarcinoma. We propose a common etiology to these canceres via tumor suppressor gene p53. Read More

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http://link.springer.com/10.1007/s12029-007-9000-0
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http://dx.doi.org/10.1007/s12029-007-9000-0DOI Listing
October 2008
5 Reads

Solitary adrenal metastasis in a patient with sigmoid colon cancer; report of a case.

Int J Gastrointest Cancer 2006 ;37(4):120-3

Department of Surgery, Teine Keijinkai Hospital, Sapporo, Hokkaido, Japan.

A 73-year-old man had sigmoidectomy for sigmoid colon cancer in December 2001. Although he was followed regularly with chemotherapy, his serum carcinoembryonic antigen (CEA) increased on August 2002. Abdominal computed tomography and magnetic resonance imaging showed a right adrenal mass and no other abnormality. Read More

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http://dx.doi.org/10.1007/s12029-007-9001-zDOI Listing
October 2008
5 Reads

Characterization of the CXCR4 signaling in pancreatic cancer cells.

Int J Gastrointest Cancer 2006 ;37(4):110-9

Oncology Research Department, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

CXCL12 and its receptor, CXCR4, are emerging as promising targets for modulating growth, angiogenesis, and metastasis in several human cancers. Indeed, blocking the receptor is sufficient to prevent metastasis and angiogenesis in experimental breast cancer xenografts. Recently, the biological effect of the CXCR4 in pancreatic cancer, one of the most deadly neoplastic diseases, has been reported. Read More

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http://dx.doi.org/10.1007/s12029-007-0011-7DOI Listing
October 2008
7 Reads

The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: a novel oncogenic pathway.

Int J Gastrointest Cancer 2006 ;37(4):103-9

Department of Pathology, University of Maryland, Baltimore, MD 21201, USA.

Background: The Hippo (Hpo) pathway is highly conserved in humans and was originally uncovered in Drosophila as a potent regulator of inhibiting cell growth and promoting apoptosis. The Hippo pathway consists of a tumor suppressor kinase cascade that negatively regulates growth and results in inactivation of a transcriptional co-activator, Yorkie (yki). The human ortholog of Yki, the yes-associated protein (YAP), has a 31% sequence identity and similar biologic activity. Read More

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http://dx.doi.org/10.1007/s12029-007-0010-8DOI Listing
October 2008
16 Reads

Ulcerous change decreases the accuracy of endoscopic ultrasonography diagnosis for the invasive depth of early gastric cancer.

Int J Gastrointest Cancer 2006 ;37(4):133-8

Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.

Background: With the development of endoscopic submucosal dissection, an expansion of the criteria for local treatment was suggested for lesions with ulcerous changes or undifferentiated-type adenocarcinoma.

Aim Of The Study: To determine the efficacy of endoscopic ultrasonography for such lesions, we retrospectively analyzed factors that influenced accurate diagnosis by endoscopic ultrasonography of the depth of tumor invasion.

Methods: We investigated 267 gastric adenocarcinomas for which histopathological results were obtained by endoscopic mucosal resection or gastrectomy. Read More

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http://link.springer.com/10.1007/s12029-007-9004-9
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http://dx.doi.org/10.1007/s12029-007-9004-9DOI Listing
October 2008
5 Reads

The association between selected risk factors for pancreatic cancer and the expression of p53 and K-ras codon 12 mutations.

Int J Gastrointest Cancer 2006 ;37(4):139-45

Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109-2029, USA.

Background: Pancreatic cancer is a major contributor to cancer mortality. Studies suggest that a few risk factors, including cigarette smoking, body mass index, having a relative with pancreatic cancer, and diabetes may be related to pancreatic cancer risk.

Aim Of The Study: We conducted a case-control study in southeastern Michigan to examine the relation between the above mentioned risk factors and mutations of the K-ras oncogene and p53 tumor suppressor gene. Read More

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http://link.springer.com/10.1007/s12029-007-9005-8
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http://dx.doi.org/10.1007/s12029-007-9005-8DOI Listing
October 2008
25 Reads

Estrogen and progesterone receptors expression in gastrointestinal stromal tumors and intramural gastrointestinal leiomyomas.

Int J Gastrointest Cancer 2006 ;37(4):129-32

Department of Pathology, New York Medical College, Valhalla, NY 10595, USA.

Gastrointestinal stromal tumors (GISTs) and leiomyomas of the gastrointestinal tract both may present as intramural smooth muscle cell tumors. Immunohistochemically, these tumors demonstrate different spectrums of protein expression, which helps in differential diagnosis. Leiomyomas of the uterine type are similar by the spectrum of protein expression to gastrointestinal leiomyomas, but they express in addition both estrogen (ER) and progesterone (PR) receptors, which makes hormonal therapy possible for these tumors. Read More

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http://dx.doi.org/10.1007/s12029-007-9003-xDOI Listing
October 2008
23 Reads

Lipoprotein receptor associated protein (LRPAP1) insertion/deletion polymorphism: association with gallbladder cancer susceptibility.

Int J Gastrointest Cancer 2006 ;37(4):124-8

Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Low-density lipoprotein receptor-related protein associated protein (LRPAP1) insertion/deletion polymorphism influences cholesterol homeostasis and may confer risk for gallstone disease and gallbladder carcinoma (GBC) incidence usually parallels with the prevalence of cholelithiosis.

Aim: We aimed to examine the role of LRPAP1 polymorphism in susceptibility to GBC.

Methods: Present case control study included 129 proven GBC patients, 183 gallstone patients, and 208 healthy controls. Read More

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http://dx.doi.org/10.1007/s12029-007-9002-yDOI Listing
October 2008
18 Reads
3 Citations

Isolated splenic metastasis from colorectal mucinous carcinoma.

Int J Gastrointest Cancer 2006 ;37(2-3):98-101

Institute of Pathology, ICMR, Safdarjung Hospital Campus, New Delhi, 110029, India.

Metastatic tumors of the spleen are rare and occur in the presence of disseminated visceral metastasis. Isolated splenic metastases from colorectal carcinoma are rare and only 19 cases have been reported in English literature. We report a case of isolated splenic metastasis in a 52-year-old man, occurring 9 years after the primary colorectal mucinous carcinoma was treated by anterior resection. Read More

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http://dx.doi.org/10.1007/s12029-007-0007-3DOI Listing
October 2012
4 Reads

Resection of small bowel adenocarcinoma liver metastasis combined with neoadjuvant and adjuvant chemotherapy results in extended disease-free period--a case report.

Int J Gastrointest Cancer 2006 ;37(2-3):94-7

Department of Internal Medicine I, University Hospital of Regensburg, Regensburg, 93042, Germany.

Small bowel adenocarcinoma (SBA) is a very rare tumor entity but occurs in up to 5% of patients suffering from familiar adenomatous polyposis (FAP). Because of nonspecific symptoms, diagnosis is usually made with delay, which contributes to high rates of metastatic disease at the time of diagnosis. The overall prognosis of SBA is poor with 5-year survival rates of 15-35%. Read More

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http://link.springer.com/10.1007/s12029-007-0005-5
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October 2012
7 Reads

Sacrococcycygeal teratoma in adult: report of a case.

Int J Gastrointest Cancer 2006 ;37(2-3):91-3

Coloproctology Discipline, Department of Surgery, University Federal of Alagoas, Rua Adelaide de Melo Mota, Maceió, and Department of General Surgery, University Hospital of the School of Medicine, University Federal of Alagoas, Maceió, Alagoas, Brazil.

Background: Sacrococcygeal teratomas are neoplasias, which are most frequently found in infants, with the sacrococcígea area being the most frequently found extragonadal location.

Aim Of The Study: To describe a sacrococcygeal teratoma in a 51-year-old adult patient and discuss the diagnosis and management.

Methods: The case of a 51-year-old woman who had a sacrococcygeal teratoma. Read More

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http://dx.doi.org/10.1007/s12029-007-0004-6DOI Listing
October 2012
5 Reads

Rodent endosonography to monitor esophageal cancer.

Int J Gastrointest Cancer 2006 ;37(2-3):84-90

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic School of Medicine, and Gastroenterology Research Unit and Barrett’s Esophagus Unit, St. Mary’s Hospital, 1216 Second Street SW, Rochester, MN 55905, USA.

Animal models of luminal cancers are important to understand and assess chemopreventive and chemotherapeutic interventions. However, the ability to assess tumor growth and response without animal sacrifice is limited. We assessed the ability of luminal sonography to assess the presence of tumor and its size in a surgical esophagojejunostomy model of esophageal cancer. Read More

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http://dx.doi.org/10.1007/s12029-007-0006-4DOI Listing
October 2012
6 Reads

Identification of CYP2C9*2 allele in HepG2 cell line.

Int J Gastrointest Cancer 2006 ;37(2-3):79-83

School of Pharmacy and Applied Science, Faculty of Science, Technology and Engineering, La Trobe University, Bendigo, Vic, 3550, Australia.

Background: Hepatoma is caused by many factors including alcohol, chemicals, viral infection, and chronic inflammation. Cytochrome P450 polymorphism plays an important role in its pathogenesis. CYP2D6, CYP2E1, and CYP1A1 have been identified to be related with hepatic carcinogenesis and tumor size and stage. Read More

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http://dx.doi.org/10.1007/s12029-007-0003-7DOI Listing
October 2012
4 Reads

"Solitary" necrotic nodule of the liver: an enigmatic entity mimicking malignancy.

Int J Gastrointest Cancer 2006 ;37(2-3):74-8

Pathology Laboratory, 2nd Surgical Clinic, University of Athens, Aretaieion Hospital, Athens, Greece.

Aim: The aim of the study is to further investigate the clinicopathological features of solitary necrotic nodules.

Material And Methods: Twenty-three archived cases of solitary necrotic nodule of the liver, which were preoperatively misdiagnosed as liver metastases were studied. The pathological findings were correlated with the clinical data of the patients. Read More

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http://dx.doi.org/10.1007/s12029-007-0002-8DOI Listing
October 2012
6 Reads

The European organization for research and treatment of cancer quality of life questionnaire: implications for prognosis in pancreatic cancer.

Int J Gastrointest Cancer 2006 ;37(2-3):65-73

Cancer Treatment Centers of America® (CTCA) at Midwestern Regional Medical Center, Zion, IL, USA.

Background: The goal of this study was to evaluate the association between patient quality of life (QoL) and survival in pancreatic cancer patients undergoing care in a community hospital comprehensive cancer center.

Patients And Methods: A consecutive case series of 55 histologically confirmed pancreatic cancer treated at Cancer Treatment Centers of America® at Midwestern Regional Medical Center was studied between 04/01 and 11/04. The EORTC QLQ-C30 was utilized to assess patient QoL. Read More

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http://dx.doi.org/10.1007/s12029-007-0001-9DOI Listing
October 2012
6 Reads

Mitochondrial DNA mutations in pancreatic cancer.

Int J Gastrointest Cancer 2006 ;37(2-3):57-64

Department of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA.

Background: Somatic mutations of mitochondrial DNA (mtDNA) are increasingly being recognized in many human cancers, but automated sequencing of 16.5 kb of DNA poses an onerous task. We have recently described an oligonucleotide microarray (MitoChip) for rapid and accurate sequencing of the entire mitochondrial genome (Zhou et al. Read More

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http://dx.doi.org/10.1007/s12029-007-0008-2DOI Listing
October 2012
5 Reads

Multiorganic dissemination of a colorectal signet ring cell carcinoma with fulminant clinical course.

Int J Gastrointest Cancer 2006 ;37(1):49-54

Division of Medical Oncology, San Filippo Neri Hospital, Rome, Italy.

Mucinous colorectal cancer with signet ring cell aspects is a rare form of adenocarcinoma representing about 2-5% of large bowel neoplasms. The tumor frequently presents with late-stage or peritoneal spreading. It can often affect young patients and diffusely infiltrate through all layers of the intestinal wall. Read More

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http://dx.doi.org/10.1385/IJGC:37:1:49DOI Listing
April 2007
8 Reads

Rapid growth of mucinous cystic adenoma of the pancreas following pregnancy.

Int J Gastrointest Cancer 2006 ;37(1):45-8

Department of Tumor Surgery, Kochi Medical School, Nankoku, Kochi 783-8505, Japan.

A 25-yr-old woman delivered a healthy child by cesarean section. At 8 mo postpartum, she became aware of an upper abdominal tumor. Abdominal computed tomography and upper abdominal ultrasonography revealed a large cystic mass in the body of the pancreas. Read More

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http://dx.doi.org/10.1385/IJGC:37:1:45DOI Listing
April 2007
15 Reads

Patient satisfaction with quality of life as a predictor of survival in pancreatic cancer.

Int J Gastrointest Cancer 2006 ;37(1):35-44

Cancer Treatment Centers of America (CTCA) at Midwestern Regional Medical Center, Zion, IL 60099, USA.

Background: The goal of this study was to evaluate the association between patient satisfaction with quality of life (QoL) and survival in pancreatic cancer patients undergoing care in a community hospital comprehensive cancer center.

Patients And Methods: A consecutive case series of 55 cases of histologically confirmed pancreatic cancer treated at Cancer Treatment Centers of America at Midwestern Regional Medical Center was studied between 04/01 and 11/04. The Quality of Life Index (QLI) was utilized to assess patient satisfaction with QoL. Read More

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http://link.springer.com/10.1385/IJGC:37:1:35
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April 2007
4 Reads

Combined hepatocholangiocarcinoma: case-series and review of literature.

Int J Gastrointest Cancer 2006 ;37(1):27-34

Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

Background And Aim: Combined hepatocholangiocarcinoma (CHCC) is an infrequent primary hepatic malignancy with no clearly defined diagnostic criteria, poorly studied natural history, and no guidelines regarding therapy. In this study we attempted to address this need and review our experience.

Methods And Results: We performed a retrospective review of all CHCC cases at our institute over the last 10 yr. Read More

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http://dx.doi.org/10.1385/IJGC:37:1:27DOI Listing
April 2007
47 Reads

Mortality predictions for esophageal, stomach, and pancreatic cancer, Ireland, up to 2015.

Int J Gastrointest Cancer 2006 ;37(1):15-25

National Cancer Registry, Boreenmanna Road, Elm Court, Cork, Ireland.

Background And Aim Of The Study: An analysis was undertaken to predict numbers of esophageal, stomach, and pancreatic cancer deaths and their World age standardized mortality rates (WASMRs) per 100,000 person years (100,000 PY-1) in Ireland for the years 2005, 2010 and 2015.

Methods: Linear and log-linear Poisson regression models were applied to 1950-2002 Irish cancer mortality data.

Results: By 2015, esophageal cancer WASMR for males is expected to rise to 9. Read More

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April 2007
4 Reads

Pathologic complete response may not represent the optimal surrogate for survival after preoperative therapy for esophageal cancer.

Int J Gastrointest Cancer 2006 ;37(1):7-14

Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.

Background: We designed a phase II trial to examine the benefit of preoperative hyperfractionated radiation therapy (XRT) and concurrent chemotherapy for patients with locally advanced esophageal cancer (LAEC).

Aim Of Study: The pathologic complete response (pCR) was the primary endpoint to estimate efficacy.

Methods: Twenty-three patients with LAEC received twice-daily XRT during wk 1 and 5 and once-daily XRT during wk 2-4 (59 Gy). Read More

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April 2007
7 Reads

CYP2C19 polymorphisms in patients with gastric and colorectal carcinoma.

Int J Gastrointest Cancer 2006 ;37(1):1-5

Department of Biochemistry, Mersin University, Turkey.

Background: It has been reported that up to 80% of human cancers arise as a consequence of environmental exposure and host susceptibility factors. Environmental carcinogens are predominantly metabolized by the cytochrome P450 (CYP) superfamily of drug- or xenobiotic-metabolizing enzymes. Genetic variations in these enzymes affect individuals' susceptibility to carcinogens. Read More

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April 2007
5 Reads

Primary minute invasive de novo colonic adenocarcinoma appearing as submucosal tumor.

Int J Gastrointest Cancer 2005 ;36(3):177-81

Department of Internal Medicine, KKR Hokuriku Hospital, Kanazawa, Japan.

A 4 mm white-yellow submucosal tumor-like lesion was detected in the sigmoid colon of an asymptomatic 52-yr-old Japanese man. Because the lesion was unexpectedly suspicious for adenocarcinoma by pathological examination of the biopsy specimen, it was treated by endoscopic mucosal resection. The specimen obtained demonstrated well-differentiated adenocarcinoma without any adenomatous element, and was located principally in the submucosal layer with a maximum depth of 1600 mum from the muscularis mucosae. Read More

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http://dx.doi.org/10.1385/IJGC:36:3:177DOI Listing
October 2006
4 Reads

Metastatic adenocarcinoma of the colon and follicular lymphoma within the same lymph node: a case report and review of the literature.

Int J Gastrointest Cancer 2005 ;36(3):171-5

Department of Pathology, Oncology/Hematology Division, Winthrop University Hospital, Mineola, NY 11501, USA.

Concomitant adenocarcinoma and non-Hodgkin's lymphoma, both located in the intestinal tract, are unusual. We report a unique case of moderately differentiated of the cecum and a simultaneous follicular lymphoma, Grade 1, of the terminal ileum and regional lymph nodes in a 55-yr-old man. One lymph node was involved by both adenocarcinoma and follicular lymphoma. Read More

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http://dx.doi.org/10.1385/IJGC:36:3:171DOI Listing
October 2006
7 Reads

Asymptomatic familial colon cancer with FDG-PET scanning for recurrent disease.

Authors:
Hugh J Freeman

Int J Gastrointest Cancer 2005 ;36(3):163-9

Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada.

A 57-yr-old female was referred for screening colonoscopy because of a positive family history of colon cancer. A lobulated tumor mass was detected in the sigmoid colon. The resected specimen showed an invasive adenocarcinoma without lymph node involvement. Read More

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http://dx.doi.org/10.1385/IJGC:36:3:163DOI Listing
October 2006
5 Reads

Colonic carcinoma resembling submucosal tumor: report of a case and review of the literature.

Int J Gastrointest Cancer 2005 ;36(3):155-61

The Department of Gastroenterology, Niigata Central Hospital, 1-18, Shinkocho, Niigata, 950-8556, Japan.

Submucosal tumor-like colorectal carcinoma, most of whose surface is covered with normal mucosa, is very rare. We report a case of colonic carcinoma resembling submucosal tumor. A 54-yr-old man visited our institution for an evaluation of a positive fecal occult blood test. Read More

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October 2006
4 Reads

Long-term results after surgery for gastric cancer with or without jejunal reservoir: results of surgery for gastric cancer in Kanta-Häme central hospital in two consecutive periods without or with jejunal pouch reconstruction in 1985-1998.

Int J Gastrointest Cancer 2005 ;36(3):147-53

Department of Surgery, Narvik Hospital, Norway.

Background: Gastric cancer still has a disease-specific 5-yr survival less than 30% and an overall survival of about 15%. The quality of life of patients who undergo gastrectomy is poor owing both to the severity of the disease itself and to the mutilation of the upper gastrointestinal channel after the reconstruction. Therefore, the combination of a jejunal pouch with gastrectomy has been claimed to improve the life quality and nutritional status of these patients. Read More

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October 2006
4 Reads

Type I collagen and divalent cation shifts disrupt cell-cell adhesion, increase migration, and decrease PTHrP, IL-6, and IL-8 expression in pancreatic cancer cells.

Int J Gastrointest Cancer 2005 ;36(3):131-46

Department of Surgery, University of California, San Diego and Veterans Affairs, San Diego Healthcare System, San Diego, CA 92161, USA.

Background: We have shown in FG pancreatic cancer cells that alpha2beta1 integrin-mediated type I collagen adhesion decreases parathyroid hormone-related protein (PTHrP), interleukin-6 (IL-6), and interleukin-8 (IL-8) expression, decreases the localization of E-cadherin and beta-catenin in cell-cell contacts, increases cell migration, and increases glycogen synthase kinase 3 (GSK3) and protein kinase B (PKB/Akt) phosphorylation states relative to alpha5beta1 integrin-mediated fibronectin (Fn) adhesion.

Aim Of The Study: To extend our observations in FG cells to other pancreatic cancer cell lines, and to determine whether E-cadherin-mediated cell-cell adhesion and its downstream effectors were functionally involved in the ECM-mediated regulation of PTHrP, IL-6, and IL-8.

Methods: We used standard biochemical techniques to determine ECM-specific differences in E-cadherin and beta-catenin localization, GSK3 and PKB/Akt phosphorylation, haptokinetic cell migration, and cytokine expression in pancreatic cancer cells. Read More

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October 2006
12 Reads

Gastric mucosal proliferative and total tyrosine kinases activities increase in Helicobacter pylori-induced chronic gastritis.

Int J Gastrointest Cancer 2005 ;36(3):121-30

Department of Digestive Tract Diseases, Medical University of Lodz, Kopcinskiego 22, Lodz 90-153, Poland.

Background: The intestinal type of gastric cancer is thought to originate from cancer precursor lesions, progressing from H. pylori-induced chronic gastritis, atrophic gastritis, to intestinal metaplasia (IM) and dysplasia. Tyrosine kinases (tyr-k) represent the family of proteins that are widely expressed during cell metabolism and are considered as secondary markers for cellular proliferation and malignant transformation. Read More

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October 2006
7 Reads

Small follicular lymphoma arising near the ampulla of vater: a distinct subtype of duodenal lymphoma?

Int J Gastrointest Cancer 2005 ;36(2):113-9

Department of Internal Medicine, KKR Hokuriku Hospital, Izumigaoka 2-13-43, Kanazawa 921-8035, Japan.

A 49-yr-old Japanese woman underwent upper gastrointestinal endoscopy because of nonspecific dyspepsia. Endoscopy revealed a flat elevated lesion about 15 mm in diameter adjacent to the duodenal papilla, the surface of which was uneven and covered with whitish granules. Based on the results of histological examination with immunohistochemistry (positive for CD10, CD20, CD79a, and bcl-2 protein, negative for CD5 and cyclin D1), a diagnosis of grade 1/3 follicular lymphoma was established. Read More

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June 2007
9 Reads

Primary malignant fibrous histiocytoma of the small bowel: a report of an additional case in duodenum.

Int J Gastrointest Cancer 2005 ;36(2):105-12

Department of Pathology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, MN 430060, China.

Aims: We report herein an additional case of primary malignant fibrous histiocytoma (MFH) in the duodenum and provide a review of the existing literature.

Methods And Results: A 61-yr-old Chinese man was admitted to our hospital with symptoms of melena, anorexia, and weight loss. An abdominal computed tomography (CT) and gastrointestinal barium meal examination demonstrated a tumor of the duodenum suggestive of primary malignancy. Read More

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June 2007
5 Reads

A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis.

Int J Gastrointest Cancer 2005 ;36(2):99-104

Department of Surgery, National Tokyo Medical Center, 2-5-1 Higashigaoka, Tokyo, 152-8902, Japan.

We report a very rare case of primary gastric small cell carcinoma (GSCC) that was accompanied with gastric tubular adenocarcinoma. A male in his 60s had an elevated tumor with a central ulceration in the middle stomach. The patient underwent a distal gastrectomy with lymph node dissection. Read More

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June 2007
15 Reads

Early colon cancer detected by 18F-FDG PET.

Int J Gastrointest Cancer 2005 ;36(2):95-8

Department of Coloproctological Surgery, Juntendo University, School of Medicine, Tokyo, Japan.

Positron emission tomography (PET) is a noninvasive functional imaging modality that can disclose the presence of a malignant disease. It has recently been reported that PET may be useful to detect primary colorectal cancer (CRC). We present the case of a 47-yr-old man with early colon cancer detected by 18F-fluorodeoxyglucose (FDG) PET. Read More

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June 2007
5 Reads

Deteriorating stage profile of gastrointestinal cancer in Finland.

Int J Gastrointest Cancer 2005 ;36(2):89-94

Department of Surgery, Narvik Hospital, Norway.

Background: The prognosis of patients with gastrointestinal (GI) cancer is mainly due to the stage of the tumor at the diagnosis. Regardless of several innovations in diagnostic and therapeutic gastroenterology, there is no longitudinal data of the trends of stage profile of patients with gastrointestinal cancer in Finland.

Aim: To study the incidence by stage of GI cancer in Finland in the past 15 yr in the entire country as well as in two subpopulations with different population profile: in a population with a small number of residents over 65 yr of age (Jorvi district) and in a population with a large number of residents over 65 yr of age (Kanta-Häme district). Read More

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June 2007
10 Reads

Four peptides decrease human colon adenocarcinoma cell number and DNA synthesis via cyclic GMP.

Int J Gastrointest Cancer 2005 ;36(2):77-87

Department of Internal Medicine, University of South Florida Cardiac Hormone Center and James A. Haley Veterans Medical Center, Tampa, 33612, USA.

Background: Mortality from colon cancer is significant with an expected 30,350 colon cancer deaths in 2005 with current treatment(s). Long-acting natriuretic peptide, vessel dilator, kaliuretic peptide, and atrial natriuretic peptide have significant anticancer effects in breast and pancreatic adenocarcinomas.

Aim Of Study: Whether these peptide hormones have anticancer effects in colon adenocarcinoma cells and whether these effects are specifically mediated by cyclic GMP has not been determined. Read More

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http://dx.doi.org/10.1385/IJGC:36:2:77DOI Listing
June 2007
4 Reads

Comparison of clinical stage, therapy response, and patient outcome between squamous cell carcinoma and adenocarcinoma of the esophagus.

Int J Gastrointest Cancer 2005 ;36(2):69-76

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA.

Purpose: To analyze the differences in clinical stage, pathologic response to chemoradiotherapy, patterns of failure, and overall survival (OS) between patients with squamous cell carcinoma (SCC) and adenocarcinoma (ACA) of the esophagus.

Patients And Methods: We stratified patients by two histologies, ACA and SCC, and statistically compared their clinical stage, post-therapy pathologic response, patterns of failure, and OS.

Results: Of the 235 patients who underwent preoperative chemoradiotherapy, 42 (18%) had SCC and 193 (82%) had ACA. Read More

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June 2007
7 Reads

Relationship of Helicobacter pylori to Bcl-2 family expression, DNA content, and pathological characteristics of gastric cancer.

Int J Gastrointest Cancer 2005 ;36(2):61-8

Molecular and Cellular Biology Department, Genetic Engineering and Biotechnology Research Institute, Minufiya University, Sadat City, Minufiya, Egypt.

Background: Despite the fact that the association of Helicobacter pylori with an increased risk of gastric cancer has been well documented, the exact mechanisms of this association have not been fully elucidated. Scarce data on H. pylori infection and its relationship with the different pathological characteristics are available in Egypt. Read More

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June 2007
6 Reads

Metastasis to appendix from lung adenocarcinoma.

Int J Gastrointest Cancer 2005 ;36(1):59-60

Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-city, Ibaraki, Japan.

We previously read with interest the case report by Filik et al. (International Journal of Gastrointestinal Cancer, 2003;34:55-58) on appendicular metastases from pancreatic adenocarcinoma. We would like to share our recent experience. Read More

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http://dx.doi.org/10.1385/IJGC:36:1:059DOI Listing
January 2006
4 Reads

Oxaliplatin-based chemotherapy for the treatment of a metastatic carcinoid tumor.

Int J Gastrointest Cancer 2005 ;36(1):55-8

Department of Gastrointestinal Oncology and Digestive Systems, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77005, USA.

Carcinoid tumors are rare and often resistant to chemotherapy agents. Although a slow-growing tumor, patients can have significant morbidity associated with carcinoid syndrome and patients will often die as a result of tumor progression. We report the first case of a patient with a metastatic carcinoid tumor to respond to an oxaliplatin-based regimen. Read More

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http://dx.doi.org/10.1385/IJGC:36:1:055DOI Listing
January 2006
5 Reads

Aberrant p16 methylation, a possible epigenetic risk factor in familial esophageal squamous cell carcinoma.

Int J Gastrointest Cancer 2005 ;36(1):47-54

Division of Human Genetics, Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran.

Aim: Detection of methylation in the p16 gene, an inhibitor of cyclin D-dependent protein kinase, as a new tumor marker for early detection of esophageal squamous cell carcinoma (ESCC) in DNA derived from blood and serum.

Method: A large family with clustering of ESCC was assessed in Khorasan province in northeastern Iran. The family had three histologically proven cases of ESCC in two consecutive generations and several other deceased cases with histories of ESCC. Read More

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http://link.springer.com/10.1385/IJGC:36:1:047
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January 2006
12 Reads

Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation.

Int J Gastrointest Cancer 2005 ;36(1):39-46

Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA.

Background: Maspin is both overexpressed in tumors and inflammation, implicating a possible role in bridging inflammation and neoplasia. Idiopathic inflammatory bowel disease (IBD) and IBD-associated dysplasias and carcinomas represent a prototype for studying the relationship between chronic inflammatory states and neoplasia.

Aim Of Study: To investigate expression of maspin in IBD and IBD-associated dysplasia and colorectal carcinoma. Read More

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http://link.springer.com/10.1385/IJGC:36:1:039
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January 2006
8 Reads

Prognostic factors in patients with colorectal cancer receiving adjuvant chemotherapy or chemoradiotherapy: a pooled analysis of two randomized studies.

Int J Gastrointest Cancer 2005 ;36(1):29-38

Dept of Clinical Therapeutics, Medical School, University of Athens, Greece.

Background: Although the TNM system is useful in predicting survival in resected colorectal cancer, heterogeneity within the same stages regarding prognosis exists. We are presenting a pooled analysis of prognostic factors from two randomized studies of adjuvant treatment conducted by the Hellenic Cooperative Oncology Group.

Patients And Methods: Patients with stage II or III colon (n = 279) or rectal (n = 220) cancer were included in this analysis. Read More

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http://link.springer.com/10.1385/IJGC:36:1:029
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January 2006
6 Reads

Induction of apoptosis and cell cycle arrest by imexon in human pancreatic cancer cell lines.

Int J Gastrointest Cancer 2005 ;36(1):15-28

The University of Arizona, College of Medicine, Department of Pharmacology, 1515 N Campbell Avenue, Tucson, Arizona 85724, USA.

Imexon is an aziridine-containing small molecule currently in Phase I clinical trials. This agent has been shown to bind to thiols and increase intracellular oxidants, inducing apoptosis in hematologic cancer cells. Pancreatic cancers are known to be sensitive to oxidation, suggesting this disease may be an appropriate target for this agent. Read More

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http://dx.doi.org/10.1385/IJGC:36:1:015DOI Listing
January 2006
5 Reads

State of the art: gastrointestinal malignancies in the human immunodeficiency virus (HIV) population.

Int J Gastrointest Cancer 2005 ;36(1):1-14

Department of Radiation Oncology, Department of Radiation Oncology, Emory University School of Medicine, 1365 Clifton Rd NE, Atlanta, GA 30344, USA.

The gastrointestinal tract is one of the most common sites for the development of primary neoplasms arising in patients with pre-existing infection with the human immunodeficiency virus (HIV). Over the past decade, new information on the clinical manifestation, natural history, treatment options, and related toxicity have been reported, mostly notably the integration of highly active antiretroviral therapy (HAART). The following is a concise review summarizing the current state-of-the-art for GI tract malignancies in the HIV-positive patient and is designed to assist the clinical oncology team in developing a rationale plan when caring for these patients. Read More

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http://dx.doi.org/10.1385/IJGC:36:1:001DOI Listing
January 2006
5 Reads

Pancreatic endocrine neoplasm can mimic serous cystadenoma.

Int J Gastrointest Cancer 2005 ;35(3):217-20

Department of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden Chikusa-ku, Nagoya, Japan.

A 57-yr-old female patient was referred to our hospital with a cystic lesion of the head of the pancreas that had been noted on abdominal computed tomography (CT). Endoscopic ultrasonography (EUS) showed a 3.0 cm rounded mass in the head of the pancreas. Read More

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December 2005
7 Reads

Gastrinoma of the stomach: a case report.

Int J Gastrointest Cancer 2005 ;35(3):211-6

Department of Medicine and Gastroenterology, Bellaria Hospital, University of Bologna, 40139 Bologna, Italy.

Gastrinomas of the stomach are extremely rare endocrine tumors producing Zollinger-Ellison syndrome. We report here the case of a patient with gastrinoma of the stomach who presented regional and hepatic metastases at the time of diagnosis. The endocrine tumor was discovered incidentally 8 yr after the onset of symptoms related to peptic ulcer, which responded to medical treatment with a proton pump inhibitor. Read More

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December 2005
6 Reads

Surgery for colorectal cancer in a low-volume unit: assessment of key issues in the achievement of acceptable clinical results.

Int J Gastrointest Cancer 2005 ;35(3):205-10

Departments of Surgery, Narvik Hospital, Norway and Jorvi Hospital, Espoo, Finland.

Background: The maintenance of modern therapeutic principles requires a proper case load to achieve acceptable surgical results. This may obligate administrative reorganization to overcome these problems and to provide an adequate level of cancer surgery.

Aim: To assess the surgical results of patients coming for surgery for colorectal cancer in a low-volume non-academic unit during the past 15 yr. Read More

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December 2005
6 Reads

Correlation between expression of orotate phosphoribosyl transferase and 5-fluorouracil sensitivity, as measured by apoptosis index in colorectal cancer tissue.

Int J Gastrointest Cancer 2005 ;35(3):197-203

The Department of Coloproctological Surgery, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

Background: 5-Fluorouracil remains a key drug in the treatment of colorectal cancer, and the development of a simple and effective test for selecting patients likely to benefit from postoperative adjuvant chemotherapy is an important objective.

Aim Of The Study: This study aimed to clarify the feasibility of measuring apoptotic cell rate (AI%) in tumor after short-term oral 5-fluorouracil administration prior to surgery with the objective of establishing a simpler method to test for sensitivity.

Methods: Forty-five colorectal cancer patients were allocated to two groups, and 21 patients were given oral 5-FU for 3 d prior to surgery. Read More

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December 2005
7 Reads

Potential role of flavonoids in the prevention of intestinal neoplasia: a review of their mode of action and their clinical perspectives.

Int J Gastrointest Cancer 2005 ;35(3):187-95

Department of Internal Medicine, Section of Gastroenterology, Community Hospital of Gross-Gerau, Wilhelm-Seipp Strasse, D-64521 Gross-Gerau, Germany.

Intestinal neoplasia (adenomas and carcinomas) can possibly be prevented by a diet rich in vegetables and fruits, treatment with aspirin and other nonsteroidal antiinflammatory drugs, and early colonoscopic removal of adenomas. Ballast, fiber, and secondary plant products could play a major role in colon cancer prevention. Recently there has been much experimental work in vitro and in vivo about flavonoids as inducers of bioprevention. Read More

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http://link.springer.com/10.1385/IJGC:35:3:187
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December 2005
6 Reads