1,374 results match your criteria International journal of experimental pathology[Journal]


Gene cloning to clinical trials-the trials and tribulations of a life with collagen.

Int J Exp Pathol 2019 Feb 26;100(1):4-11. Epub 2019 Mar 26.

Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

This review, based on the BSMB Fell-Muir Lecture I presented in July 2018 at the Matrix Biology Europe Conference in Manchester, gives a personal perspective of my own laboratory's contributions to research into type X collagen, metaphyseal chondrodysplasia type Schmid and potential treatments for this disorder that are currently entering clinical trial. I have tried to set the advances made in the context of the scientific technologies available at the time and how these have changed over the more than three decades of this research. Read More

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http://dx.doi.org/10.1111/iep.12311DOI Listing
February 2019
1 Read

Investigation of expressions of PDK1, PLK1 and c-Myc in diffuse large B-cell lymphoma.

Int J Exp Pathol 2019 Feb 25;100(1):32-40. Epub 2019 Mar 25.

Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. Because the prognosis of DLBCL patients varies considerably, there is an urgent need to identify novel prognostic factors. In this study, we investigated the expression levels of the signalling enzyme 3-phosphoinositide-dependent protein kinase-1 (PDK1), the cell cycle regulatory enzyme Polo-like kinase 1 (PLK1) and the transcription factor (c-Myc) in DLBCL tissues and evaluated their clinical and prognostic significance. Read More

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http://dx.doi.org/10.1111/iep.12307DOI Listing
February 2019
2 Reads

Vitronectin deficiency attenuates hepatic fibrosis in a non-alcoholic steatohepatitis-induced mouse model.

Int J Exp Pathol 2019 Mar 18. Epub 2019 Mar 18.

Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo, Japan.

Vitronectin (VN), an extracellular matrix protein, is a promising immune biomarker of non-alcoholic steatohepatitis (NASH); however, its precise function remains unclear. This study investigated how VN deficiency contributes to the development of NASH. Towards this aim, wild-type (WT) and VN-/- mice were fed with a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) for 6 and 10 weeks to induce NASH, and the livers were isolated. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/iep.12306
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http://dx.doi.org/10.1111/iep.12306DOI Listing
March 2019
8 Reads
2.168 Impact Factor

KRAS mutations in the parental tumour accelerate in vitro growth of tumoroids established from colorectal adenocarcinoma.

Int J Exp Pathol 2019 Feb 18;100(1):12-18. Epub 2019 Mar 18.

2cureX, Birkeroed, Denmark.

The aim of the present study was to characterize a patient-derived in vitro 3D model (ie tumoroid) established from colorectal adenocarcinoma. This study investigated the growth rate of tumoroids and whether the Kirsten rat sarcoma (KRAS) mutations in the parental tumour accelerate this rate. The tumoroids were established from surgical resections of primary and metastatic colorectal adenocarcinoma from 26 patients. Read More

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http://dx.doi.org/10.1111/iep.12308DOI Listing
February 2019
2 Reads

CARLo-7-A plausible biomarker for bladder cancer.

Int J Exp Pathol 2019 Feb 18;100(1):25-31. Epub 2019 Mar 18.

Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.

Cancer is defined as undifferentiated and unchecked growth of cells damaging the surrounding tissue. Cancers manifest altered gene expression. Gene expression is regulated by a diverse array of non-protein-coding RNA. Read More

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http://dx.doi.org/10.1111/iep.12305DOI Listing
February 2019
2.168 Impact Factor

Role of CD97 small isoform in human cervical carcinoma.

Int J Exp Pathol 2019 Feb 18;100(1):19-24. Epub 2019 Mar 18.

Department of Pathology, West China Second Hospital of Sichuan University, Sichuan, China.

Various studies revealed that elevated expression of CD97 in carcinomas is associated with the dedifferentiation, aggressiveness and metastasis of tumour. CD97 is a protein member of the epidermal growth factor seven-transmembrane (EGF-TM7) family of class II TM7 receptors. Our previous study suggested that the overexpression of CD97 in cervical cancer was correlated with the aggressiveness of the tumour and that CD97 might be an independent poor prognostic factor for cervical cancer patients. Read More

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http://dx.doi.org/10.1111/iep.12303DOI Listing
February 2019

Effects of three-month streptozotocin-induced diabetes in mice on blood platelet reactivity, COX-1 expression and adhesion potential.

Int J Exp Pathol 2019 Feb 27;100(1):41-48. Epub 2019 Feb 27.

Department of Haemostatic Disorders, Chair of Biomedical Sciences, Faculty of Health Sciences, Medical University of Lodz, Lodz, Poland.

Diabetes is associated with an increased risk of cardiovascular disease. This is partially attributed to an altered activation status of blood platelets in this disease. Previously, alterations have been shown in COX-1 and protease activated receptor (PAR)-3 receptor expression in platelets in two animal models of diabetes, there have not been studies which address expression of these proteins in mice with long-term streptozotocin (STZ)-induced diabetes. Read More

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http://dx.doi.org/10.1111/iep.12298DOI Listing
February 2019
1 Read

Nicotinamide riboside has protective effects in a rat model of mesenteric ischaemia-reperfusion.

Int J Exp Pathol 2018 12;99(6):304-311

Children's Scientific and Clinical Center of Infectious Diseases Federal Medical and Biological Agency, Saint-Petersburg, Russia.

Acute mesenteric ischaemia is a syndrome caused by inadequate blood flow through the mesenteric vessels, resulting in ischaemia and eventual gangrene of the bowel wall. Although relatively rare, it is a potentially life-threatening condition. The maintenance of haemodynamic stability, along with adequate oxygen saturation, and the correction of any electrolyte imbalance, are of the utmost importance. Read More

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http://dx.doi.org/10.1111/iep.12302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384503PMC
December 2018
6 Reads

Morphofunctional characteristics of skeletal muscle in rats with cerebral palsy.

Int J Exp Pathol 2019 Feb 17;100(1):49-59. Epub 2019 Feb 17.

Programa de Pós-Graduação em Biociências e Saúde, Universidade Estadual do Oeste do Paraná - UNIOESTE, Cascavel, Paraná, Brazil.

Knowledge of skeletal muscle adaptations is important to understand the functional deficits in cerebral palsy (CP). This study aimed to investigate the morphofunctional characteristics of skeletal muscle in a CP animal model. Initially, pregnant Wistar rats were injected intraperitoneally with saline or lipopolysaccharide over the last five days of pregnancy. Read More

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http://doi.wiley.com/10.1111/iep.12304
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http://dx.doi.org/10.1111/iep.12304DOI Listing
February 2019
11 Reads

Death of chondrocytes in Kashin-Beck disease: Apoptosis, necrosis or necroptosis?

Int J Exp Pathol 2018 12 24;99(6):312-322. Epub 2019 Jan 24.

School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.

The purpose of this paper was to investigate chondrocyte distribution and death in the cartilage in Kashin-Beck disease (KBD). Apoptotic chondrocytes were detected by TUNEL assay. Ultrastructural changes were examined by transmission electron microscope (TEM). Read More

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http://doi.wiley.com/10.1111/iep.12297
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http://dx.doi.org/10.1111/iep.12297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384500PMC
December 2018
13 Reads

Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model.

Int J Exp Pathol 2018 12 24;99(6):282-294. Epub 2019 Jan 24.

Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama, Japan.

Non-alcoholic steatohepatitis (NASH) is linked to increased cardiovascular risk, independent of the broad spectrum of metabolic syndrome risk factors. Stroke-prone (SP) spontaneously hypertensive rats (SHRSP5/Dmcr) fed a high-fat and high-cholesterol (HFC) diet developed hepatic lesions similar to those in human NASH pathology. These rats simultaneously developed lipid deposits in the mesenteric arteries, cardiac fibrosis, endothelial dysfunction and left ventricle (LV) diastolic dysfunction. Read More

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http://dx.doi.org/10.1111/iep.12301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384504PMC
December 2018
3 Reads

TGFβ1-induced cell motility but not cell proliferation is mediated through Cten in colorectal cancer.

Int J Exp Pathol 2018 12 15;99(6):323-330. Epub 2019 Jan 15.

Division of Cancer and Stem Cells, Queen's Medical Centre, School of Medicine, University of Nottingham, Nottingham, UK.

Cten (C-terminal tensin-like) is a member of the tensin protein family found in complex with integrins at focal adhesions. It promotes epithelial-mesenchymal transition (EMT) and cell motility. The precise mechanisms regulating Cten are unknown, although we and others have shown that Cten could be under the regulation of several cytokines and growth factors. Read More

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http://dx.doi.org/10.1111/iep.12300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384513PMC
December 2018
1 Read

Muscle wasting and branched-chain amino acid, alpha-ketoglutarate, and ATP depletion in a rat model of liver cirrhosis.

Int J Exp Pathol 2018 12 13;99(6):274-281. Epub 2019 Jan 13.

Department of Physiology, Faculty of Medicine in Hradec Kralove, Charles University, Czech Republic.

The aim of the study was to examine whether a rat model of liver cirrhosis induced by carbon tetrachloride (CCl4) is a suitable model of muscle wasting and alterations in amino acid metabolism in cirrhotic humans. Rats were treated by intragastric gavage of CCl4 or vehicle for 45 days. Blood plasma and different muscle types-tibialis anterior (mostly white fibres), soleus (red muscle) and extensor digitorum longus (white muscle) - were analysed at the end of the study. Read More

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http://dx.doi.org/10.1111/iep.12299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384501PMC
December 2018
1 Read

Establishment of a diabetic myocardial hypertrophy model in Mus musculus castaneus mouse.

Int J Exp Pathol 2018 12 6;99(6):295-303. Epub 2019 Jan 6.

Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, China.

The aim of this study was to establish a robust model of diabetic myocardial hypertrophy in Mus musculus castaneus mice. Mice were fed a high-fat diet for four weeks and then given streptozotocin (STZ, 40 mg kg  d for 5 days, intraperitoneally) and fasting blood glucose (FBG) levels were tested after seven days. Mice with FBG levels above 11. Read More

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http://doi.wiley.com/10.1111/iep.12296
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http://dx.doi.org/10.1111/iep.12296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384502PMC
December 2018
11 Reads

Histopathological features of skin lesions in patients affected by non-ulcerated or atypical cutaneous leishmaniasis in Honduras, Central America.

Int J Exp Pathol 2018 10 27;99(5):249-257. Epub 2018 Nov 27.

Laboratory of Pathology of Infectious Diseases, Medical School, São Paulo University, São Paulo, SP, Brazil.

In Honduras visceral leishmaniasis and non-ulcerated or atypical cutaneous leishmaniasis (NUCL) are caused by the species Leishmania (L.) infantum chagasi. NUCL is the most common clinical form in the southern regions of the country, mainly affecting the young. Read More

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http://dx.doi.org/10.1111/iep.12295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302788PMC
October 2018
2 Reads

Nitrogen-containing bisphosphonate therapy-Part II: Assessment of alveolar bone tissue inflammatory response in rats-A blind randomized controlled trial.

Int J Exp Pathol 2018 10 20;99(5):258-263. Epub 2018 Nov 20.

Oral and Maxillofacial Surgery Unit/Clinical Hospital of Porto Alegre (HCPA), School of Dentistry/Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

This study aimed to evaluate the alveolar bone tissue inflammatory response in rats undergoing zoledronic acid therapy. The study sample was composed of 28 Wistar rats. Animals from the test group GTa received a weekly intraperitoneal dose of 0. Read More

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http://dx.doi.org/10.1111/iep.12291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302789PMC
October 2018
17 Reads

Systemic alterations induced by phospholipase A , BmooTX-I, isolated from Bothrops moojeni snake venom.

Int J Exp Pathol 2018 10 20;99(5):226-235. Epub 2018 Nov 20.

Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.

Ophidic accidents are among the problems of public health in Brazil. The components from bothropic venom are responsible for many systemic clinical complications resulting from envenomation. The present work aimed to analyse the systemic changes induced in mice after intraperitoneal administration of BmooTX-I, a myotoxic acidic phospholipase A isolated from Bothrops moojeni venom. Read More

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http://dx.doi.org/10.1111/iep.12290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302785PMC
October 2018
4 Reads

Omega-6 fatty acids down-regulate matrix metalloproteinase expression in a coronary heart disease-induced rat model.

Int J Exp Pathol 2018 10 15;99(5):210-217. Epub 2018 Nov 15.

Department of Cardiology, Kunming General Hospital of Chengdu Military Area, Kunming Medical University, Kunming, China.

The present study investigated the therapeutic potential of omega-6 fatty acids, according to their effects on antioxidant markers and matrix metalloproteinases (MMPs), in coronary heart disease-induced rats. Rats were grouped into group I (sham control), group II (control), group III (0.5 g/kg bwt of omega-6 fatty acids) and group IV (1 g/kg bwt of omega-6 fatty acids). Read More

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http://doi.wiley.com/10.1111/iep.12293
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http://dx.doi.org/10.1111/iep.12293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302899PMC
October 2018
14 Reads
2.168 Impact Factor

Can the indicators of chronic ethanol consumption be minimized by a continuous flaxseed intake?

Int J Exp Pathol 2018 10 19;99(5):218-225. Epub 2018 Oct 19.

Laboratory of Experimental Nutrition, Department of Nutrition and Dietetics, Nutrition College, Federal Fluminense University, Niterói, RJ, Brazil.

The aim of this study was to evaluate the use of flaxseed in animals subjected to ethanol-induced hepatotoxicity. Twenty-four male rats were divided into four groups (n = 6): control group (CG) which received a control diet and water ad libitum; flaxseed group (FG) which received control diet with an addition of 25% flaxseed flour and water ad libitum; ethanol control group (ECG) which received control diet and a solution of 10% ethanol (v/v) as the only liquid source; and ethanol flaxseed group (EFG) which received control diet with an addition of 25% flaxseed flour and a solution of 10% ethanol (v/v) as the only liquid source. The animals were euthanized at 60 days, when blood was collected for biochemical analysis and liver was collected for histomorphometric analysis. Read More

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http://doi.wiley.com/10.1111/iep.12288
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http://dx.doi.org/10.1111/iep.12288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302787PMC
October 2018
11 Reads

Cellular profile of primary molars with pulp necrosis after treatment with antibiotic paste.

Int J Exp Pathol 2018 10 15;99(5):264-268. Epub 2018 Oct 15.

Department of Morphology, Federal University of Piauí, Teresina, Piauí, Brazil.

The interradicular region of primary molars is permeated by many foramina, channels and accessories that connect the pulp cavity with the periapical tissues anatomically. Thus, pulp decomposition products or drugs used in endodontic treatment can trigger inflammatory reactions. The aim of this study was to evaluate the blood cell profile of the alveolar region after extraction of primary molars treated with CTZ paste. Read More

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http://doi.wiley.com/10.1111/iep.12292
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http://dx.doi.org/10.1111/iep.12292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302786PMC
October 2018
14 Reads

Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation-A histopathological study.

Int J Exp Pathol 2018 10 15;99(5):236-248. Epub 2018 Oct 15.

São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Lapdesf - Laboratory of Research and Development of Drugs, Araraquara, São Paulo, Brazil.

Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. In the present study, we induced the indeterminate form of Chagas disease in mice with a Y strain of Trypanosoma cruzi and analysed the histopathological data about the effects of NFOH and BZN on different tissues, including the heart, skeletal muscle, liver, kidney, colon, spleen and brain. After infection, BALB/c mice were treated with NFOH (150 mg/kg) and BZN (60 mg/kg) for 60 days and then submitted to immunosuppression using dexamethasone (5 mg/kg) for 14 days. Read More

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http://doi.wiley.com/10.1111/iep.12289
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http://dx.doi.org/10.1111/iep.12289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302791PMC
October 2018
11 Reads

Histopathological changes in androgenized ovaries are recovered by melatonin treatment.

Int J Exp Pathol 2018 08;99(4):158-171

Departamento de Biotecnologia, Faculdade de Ciências e Letras, Universidade Estadual Paulista - UNESP, Assis, São Paulo, Brazil.

Nandrolone decanoate (ND) is a synthetic steroid, which promotes adverse effects on the ovarian tissue, and melatonin (MLT) exhibits a number of beneficial properties in the reproductive system. This study evaluated the general features of the ovarian tissue and the immunoexpression of sex steroid receptors in ND-treated rats that were submitted to short-term melatonin treatment. Adult rats received mineral oil (control group) and ND at doses of 7. Read More

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http://dx.doi.org/10.1111/iep.12283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157297PMC
August 2018
14 Reads

Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetic gerbils (Gerbillus gerbillus).

Int J Exp Pathol 2018 08;99(4):172-179

Department of Biology and Physiology of Organisms (LBPO), Nutrition-Metabolism/FSB/USTHB, Algiers, Algeria.

This study was designed to investigate the HPA-axis impairment in the streptozotocin (STZ)-diabetic gerbils (Gerbillus gerbillus). Twenty-six male gerbils (body weight ~27 g) were divided into 3 groups: vehicle control (n = 10), 2 days of diabetes (n = 09) and 30 days of diabetes (n = 07). The latter 2 groups received an intraperitoneal injection of STZ (150 mg/kg of body weight). Read More

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http://dx.doi.org/10.1111/iep.12284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157299PMC
August 2018
3 Reads

Adaptive growth changes in the liver remnant are affected by the size of hepatectomy in rats.

Int J Exp Pathol 2018 08 10;99(4):150-157. Epub 2018 Sep 10.

Section for Upper Gastrointestinal and Hepato-Pancretico-Biliary Surgery, Department of Surgical Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

In this study we investigated the dynamics of hepatocyte hyperplasia and hypertrophy in rats subjected to increasing sizes of partial hepatectomy (PH). A total of 104 rats were randomized according to the size of PH. On postoperative days (PODs) 1, 3 and 5, blood was drawn and the remnant liver removed for stereological analysis. Read More

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http://dx.doi.org/10.1111/iep.12282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157304PMC
August 2018
4 Reads

Neuroprotective effect of carnosine in the olfactory bulb after vanadium inhalation in a mouse model.

Int J Exp Pathol 2018 08 9;99(4):180-188. Epub 2018 Sep 9.

Departamento de Biología Celular y Tisular, Facultad de Medicina, UNAM, México City, México.

Carnosine (β-alanyl-L-histidine) is synthesized in the olfactory system, has antioxidant activity as a scavenger of free radicals and has been reported to have neuroprotective action in diseases which have been attributed to oxidative damage. In neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases, impairment of olfactory function has been described. Vanadium derivatives are environmental pollutants, and its toxicity has been associated with oxidative stress. Read More

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http://doi.wiley.com/10.1111/iep.12285
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http://dx.doi.org/10.1111/iep.12285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157302PMC
August 2018
18 Reads

A histomorphometric classification system for normal and inflamed mouse duodenum-Quali-quantitative approach.

Int J Exp Pathol 2018 08 2;99(4):189-198. Epub 2018 Sep 2.

Gastrointestinal Immunology Group, Department of Immunobiology, Institute of Biology, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.

Gut-associated intestinal lymphoid tissue, the largest secondary lymphoid organ in the human body, constantly samples antigens from the gut lumen, presenting as a default response the activation of TCD4 FOXP3 regulatory T cells that secrete a profile of anti-inflammatory cytokines maintaining gut homeostasis denominated from an immunological perspective as mucosal tolerance. However, when antigens are sampled in an inflammatory setting, the immune response may either be protective, in the case of harmful pathogens, or cause further inflammatory reactions as in food allergy, inflammatory bowel diseases, coeliac disease or food protein-induced enterocolitis syndrome. Therefore, there is a need for accurate and consistent experimental models. Read More

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http://dx.doi.org/10.1111/iep.12286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157301PMC
August 2018
1 Read

Association of miR-1247-5p expression with clinicopathological parameters and prognosis in breast cancer.

Int J Exp Pathol 2018 08 3;99(4):199-205. Epub 2018 Sep 3.

Department of Breast Disease, Peking University Shougang Hospital, Beijing, China.

Our study aimed to clarify the correlation between miR-1247-5p expression and clinicopathological parameters and survival of patients with breast cancer (BC). We evaluated the expression level of miR-1247-5p in 224 formalin-fixed, paraffin-embedded specimens (112 BC and matched cancer free tissues) by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR). miR-1247-5p expression in BC tissues was found to be decreased compared with matched normal tissues (P < 0. Read More

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http://dx.doi.org/10.1111/iep.12287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157300PMC
August 2018
3 Reads

Corrigendum.

Authors:

Int J Exp Pathol 2018 06;99(3):145

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http://dx.doi.org/10.1111/iep.12274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104421PMC
June 2018
6 Reads

Transforming growth factor-β1 (TGF-β1) induces mouse precartilaginous stem cell differentiation through TGFRII-CK1ε-β-catenin signalling.

Int J Exp Pathol 2018 06 2;99(3):113-120. Epub 2018 Aug 2.

Department of Orthopedics, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.

Precartilaginous stem cells (PSCs) are adult stem cells which could self-renew or differentiate into chondrocytes to promote bone growth. In this study, we aimed to understand the role of transforming growth factor-β1 (TGF-β1) in precartilaginous stem cell (PSC) differentiation and to study the mechanisms that underlie this role. We purified PSCs from the neonatal murine perichondrial mesenchyme using immunomagnetic beads, and primary cultured them. Read More

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http://dx.doi.org/10.1111/iep.12275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104439PMC
June 2018
2 Reads

Influence of hyperthermal regimes on experimental teratoma development in vitro.

Int J Exp Pathol 2018 06 1;99(3):131-144. Epub 2018 Aug 1.

Department of Medical Biology, University of Zagreb School of Medicine, Zagreb, Croatia.

We screened for the impact of hyperthermal regimes varying in the cumulative equivalent minutes at 43°C (CEM43°C) and media composition on tumour development using an original teratoma in vitro model. Rat embryos (three germ layers) were microsurgically isolated and cultivated at the air-liquid interface. During a two week period, ectodermal, mesodermal and endodermal derivatives developed within trilaminar teratomas. Read More

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http://dx.doi.org/10.1111/iep.12273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104434PMC
June 2018
4 Reads

Leptin and Leptin receptor polymorphisms, plasma Leptin levels and obesity in Tunisian volunteers.

Int J Exp Pathol 2018 06 11;99(3):121-130. Epub 2018 Jun 11.

Biochemistry Department, LR12SP11, Sahloul University Hospital, Sousse, Tunisia.

Adipose tissue is an important endocrine organ that secretes a number of adipokines, like Leptin (LEP). The aim this study was to investigate the prevalence of single nucleotide polymorphisms in LEP gene (LEP 3'UTR A/C, -2548 G/A) and LEPR (K109R and Q223R) and their association with Leptin level and obesity. We recruited 169 non-obese (body mass index [BMI] = 24. Read More

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http://dx.doi.org/10.1111/iep.12271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104422PMC
June 2018
11 Reads
1 Citation
2.170 Impact Factor

The many ways to mend your liver: A critical appraisal.

Authors:
Malcolm R Alison

Int J Exp Pathol 2018 06 7;99(3):106-112. Epub 2018 Jun 7.

Centre for Tumour Biology, Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, London, UK.

In the latter half of the 20th century, our understanding of mammalian liver regeneration was shaped by the manner of compensatory hyperplasia occurring after a partial rat liver resection. This response involves almost all hepatocytes and thus is unlikely to be the outcome of the multiple cycling of a small stem cell population. It was most intense in the outer third of lobule, the location closest to the afferent arterial blood supply. Read More

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http://dx.doi.org/10.1111/iep.12272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104440PMC
June 2018
4 Reads

Intermittent resistance exercise and obesity, considered separately or combined, impair spermatic parameters in adult male Wistar rats.

Int J Exp Pathol 2018 04 21;99(2):95-102. Epub 2018 May 21.

General Biology Department, Biological Sciences Center, State University of Londrina-UEL, Londrina, Brazil.

Obesity and absence of physical exercise are global problems that affect concentration and sperm quality in the male reproductive system. The purpose of this study was to examine the effect of obesity and resistance training, considered separately or in association, on testicular function and reproductive capacity. Twenty pubertal male Wistar rats were distributed into four groups: control (C) and exercise (E) groups that received standard rat chow; and obese (O) and obese with exercise (OE) groups that received a high-fat diet. Read More

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http://dx.doi.org/10.1111/iep.12270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031879PMC
April 2018
9 Reads

Charting the unexplored extracellular matrix in cancer.

Int J Exp Pathol 2018 04 19;99(2):58-76. Epub 2018 Apr 19.

Cancer Division, Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, New South Wales, Australia.

The extracellular matrix (ECM) is present in all solid tissues and considered a master regulator of cell behaviour and phenotype. The importance of maintaining the correct biochemical and biophysical properties of the ECM, and the subsequent regulation of cell and tissue homeostasis, is illustrated by the simple fact that the ECM is highly dysregulated in many different types of disease, especially cancer. The loss of tissue ECM homeostasis and integrity is seen as one of the hallmarks of cancer and typically defines transitional events in progression and metastasis. Read More

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http://dx.doi.org/10.1111/iep.12269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031881PMC
April 2018
7 Reads

MiR-193a-3p functions as a tumour suppressor in human aldosterone-producing adrenocortical adenoma by down-regulating CYP11B2.

Int J Exp Pathol 2018 04 17;99(2):77-86. Epub 2018 Apr 17.

Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.

The mechanism of aldosterone-producing adrenocortical adenoma (APA) pathogenesis and the role of microRNAs (miRNAs) in APA pathogenesis have not been completely clarified. We examined the expression and function of miR-140-3p, miR-193a-3p and miR-22-3p, which have binding sites in CYP11B2. Expression of miRNAs and CYP11B2 mRNA was measured by quantitative reverse transcription PCR (qRT-PCR). Read More

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http://dx.doi.org/10.1111/iep.12267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031877PMC
April 2018
9 Reads

Overexpression of epidermal growth factor receptor and its downstream effector, focal adhesion kinase, correlates with papillary thyroid carcinoma progression.

Int J Exp Pathol 2018 04 17;99(2):87-94. Epub 2018 Apr 17.

Institute for the Application of Nuclear Energy - INEP, University of Belgrade, Belgrade-Zemun, Serbia.

Epidermal growth factor receptor (EGFR) and its downstream effector, focal adhesion kinase (FAK), have been shown to be overexpressed frequently in human malignancies and implicated in tumour aggressiveness. We aimed to investigate the relationship between EGFR and FAK expression and their possible correlation with the clinical phenotype of patients with papillary thyroid carcinoma (PTC). Expression profiles of EGFR and FAK were analysed in PTC tissue samples (n = 104) by immunohistochemistry and Western blotting. Read More

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http://dx.doi.org/10.1111/iep.12268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031876PMC
April 2018
2 Reads

Evaluation of high-fat high-fructose diet treatment in factor VIII (coagulation factor)-deficient mouse model.

Int J Exp Pathol 2018 02 15;99(1):46-53. Epub 2018 Apr 15.

National Institute of Immunology, New Delhi, India.

Non-alcoholic fatty liver disease (NAFLD)-like conditions enhance the production and action of clotting factors in humans. However, studies examining the effect of NAFLD due to high-fat high-fructose (HFHF) diet in factor VIII-deficient (haemophilia A) animals or patients have not been reported previously. In this study, we investigated the individual role of factor VIII in the progression of diet-induced NAFLD in the factor 8 (F8 ) mouse model system and its consequences on the haemophilic status of the mice. Read More

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http://dx.doi.org/10.1111/iep.12264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917390PMC
February 2018
5 Reads
2.170 Impact Factor

Reduced expression of oestrogen receptor-β is associated with tumour invasion and metastasis in oestrogen receptor-α-negative human papillary thyroid carcinoma.

Int J Exp Pathol 2018 02 14;99(1):15-21. Epub 2018 Apr 14.

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, China.

Oestrogens play an important role in the development and progression of papillary thyroid carcinoma (PTC) through oestrogen receptor (ER)-α and -β, which may exert different or even opposing actions in PTC. The roles of ERβ in ERα-negative PTC are still not clear. This study investigated the expression dynamics of ERβ1 (wild-type ERβ) and its clinical significance in female ERα-negative PTC patients. Read More

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http://dx.doi.org/10.1111/iep.12266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917391PMC
February 2018
3 Reads

Focal, but not global, cerebral ischaemia causes loss of myenteric neurons and upregulation of vasoactive intestinal peptide in mouse ileum.

Int J Exp Pathol 2018 02 25;99(1):38-45. Epub 2018 Mar 25.

Neurogastroenterology, Department of Experimental Medical Science, Lund University, Lund, Sweden.

Reduced blood flow to the brain induces cerebral ischaemia, potentially causing central injury and peripheral complications including gastrointestinal (GI) dysfunction. The pathophysiology behind GI symptoms is suspected to be neuropathy in the enteric nervous system (ENS), which is essential in regulating GI function. This study investigates if enteric neuropathy occurs after cerebral ischaemia, by analysing neuronal survival and relative numbers of vasoactive intestinal peptide (VIP) and neuronal nitric oxide synthase (nNOS) expressing neurons in mouse ileum after three types of cerebral ischaemia. Read More

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http://dx.doi.org/10.1111/iep.12263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917387PMC
February 2018
5 Reads

Extracellular matrix internalization links nutrient signalling to invasive migration.

Authors:
Elena Rainero

Int J Exp Pathol 2018 02 24;99(1):4-9. Epub 2018 Mar 24.

Biomedical Science Department, The University of Sheffield, Sheffield, UK.

Integrins are the key mediators of cell-extracellular matrix (ECM) interaction, linking the ECM to the actin cytoskeleton. Besides localizing at the cell surface, they can be internalized and transported back to the plasma membrane (recycled) or delivered to the late endosomes/lysosomes for degradation. We and others have shown that integrin can be endocytosed together with their ECM ligands. Read More

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http://dx.doi.org/10.1111/iep.12265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917393PMC
February 2018
3 Reads

Mild diabetes: long-term effects on gastric motility evaluated in rats.

Int J Exp Pathol 2018 02 26;99(1):29-37. Epub 2018 Feb 26.

Federal University of Mato Grosso - UFMT, Barra do Garças/MT, Brazil.

Moderate hyperglycaemic levels seem to be related to abnormal gastric motility in diabetes mellitus. However, experimental models designed to evaluate the relationship between motility and diabetes over time are not yet well established. Our objective was to investigate the long-term effects of mild diabetes on gastric motility in rats. Read More

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http://dx.doi.org/10.1111/iep.12262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917388PMC
February 2018
3 Reads

Correlation between testicular mast cell count and spermatogenic epithelium in non-obstructive azoospermia.

Int J Exp Pathol 2018 02 26;99(1):22-28. Epub 2018 Feb 26.

Department of General Surgery, Mansoura University Hospitals, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Although there is emerging evidence that mast cells are involved in infertility, their exact role has not been elucidated clearly. Here we carried out a retrospective case-control study to find out whether there is a correlation between mast cell (MC) count and proliferation (Ki67 index) of the spermatogenic epithelium as well as of the Sertoli cells (vimentin-positive) in non-obstructive azoospermia (NOA). We assessed MCs, Ki67 and vimentin expression in Sertoli cells in testicular biopsies of germ cell aplasia (GCA, n = 14) and maturation arrest (MA, n = 14) vs. Read More

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http://dx.doi.org/10.1111/iep.12261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917392PMC
February 2018
3 Reads
2.170 Impact Factor

Immunohistochemical assessment of Survivin and Bcl3 expression as potential biomarkers for NF-κB activation in the Barrett metaplasia-dysplasia-adenocarcinoma sequence.

Int J Exp Pathol 2018 02 23;99(1):10-14. Epub 2018 Feb 23.

Research Department of Tissue and Energy, Division of Surgery & Interventional Science, University College London, London, UK.

Non-dysplastic Barrett's oesophagus (NDBE) occurs as a consequence of an inflammatory response triggered through prolonged gastro-oesophageal reflux and it may precede the development of oesophageal adenocarcinoma. NF-κB activation as a result of the inflammatory response has been shown in NDBE, but the possible mechanism involved in the process is unknown. The aim of this study was to assess, using immunohistochemistry, Survivin and Bcl3 expression as potential biomarkers for NF-κB activation along the oesophageal metaplasia-dysplasia-adenocarcinoma sequence. Read More

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http://dx.doi.org/10.1111/iep.12260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917386PMC
February 2018
11 Reads

Treatment with low doses of aspirin during chronic phase of experimental Chagas' disease increases oesophageal nitrergic neuronal subpopulation in mice.

Int J Exp Pathol 2017 12 19;98(6):356-362. Epub 2018 Jan 19.

Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil.

Patients with Chagas' disease may develop dysfunctions of oesophageal and colonic motility resulting from the degeneration or loss of the myenteric neurons of the enteric nervous system. Studies have shown that the use of aspirin, also known as acetylsalicylic acid (ASA), influences the pathogenesis of the disease. However, this remains controversial. Read More

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http://dx.doi.org/10.1111/iep.12259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826942PMC
December 2017
6 Reads

Histopathological and immunohistochemical characterization of Burkholderia pseudomallei lesions in an acute model of infection with BALB/c mice.

Int J Exp Pathol 2017 12 7;98(6):347-355. Epub 2018 Jan 7.

CBR Division, Defence Science & Technology Laboratory, Salisbury, UK.

Organ tissue damage is a key contributor to host morbidity and mortality following infection with microbial agents. Severe immune responses, excessive cellular recruitment and necrosis of cells all play a role in disease pathology. Understanding the pathogenesis of disease can aid in identifying potential new therapeutic targets or simply act as a diagnostic tool. Read More

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http://doi.wiley.com/10.1111/iep.12258
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http://dx.doi.org/10.1111/iep.12258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826972PMC
December 2017
7 Reads

Promoter hypermethylation of SOX11 correlates with adverse clinicopathological features of human prostate cancer.

Int J Exp Pathol 2017 12 8;98(6):341-346. Epub 2018 Jan 8.

Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Currently available tools for early diagnosis and prognosis of prostate cancer lack sufficient accuracy. There is a need to identify novel biomarkers for this common malignancy. SOX family genes play an important role in embryogenesis and are also implicated in various cancers. Read More

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http://dx.doi.org/10.1111/iep.12257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826943PMC
December 2017
4 Reads

Resveratrol attenuates reproductive alterations in type 1 diabetes-induced rats.

Int J Exp Pathol 2017 12 29;98(6):312-328. Epub 2017 Dec 29.

Laboratory of Developmental Biology, Department of Morphology and Genetics, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.

The progression of diabetes mellitus leads to several complications including overproduction of reactive oxygen species and reproductive alterations. As resveratrol (RES) is a powerful anti-oxidant and an anti-apoptotic compound, we hypothesized that side effects of type-1 diabetes (DM1) on male reproduction could be reduced by the RES treatment. Eighty-four prepubertal male rats were distributed into seven groups: sham-control (SC), RES-treated (R), resveratrol-vehicle-treated (RV), diabetic (D), diabetic-insulin-treated (DI), diabetic-RES-treated (DR), diabetic-insulin and RES-treated (DIR). Read More

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http://dx.doi.org/10.1111/iep.12251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826946PMC
December 2017
4 Reads

Treatment-related changes after short-term exposure of SD rats to Aloe vera whole-leaf freeze-dried powder.

Int J Exp Pathol 2017 10;98(5):248-259

West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.

Aloe vera is a widely used natural herb from which many sorts of commercial products have been derived using different preparation technologies. Aloe whole-leaf powder is one of the most popular subtypes. The long-term impact of aloe products has already been reported; however, there have been few studies about short-term exposure, and especially about the relative impact of Aloe vera whole-leaf freeze-dried powder (AWFP). Read More

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http://dx.doi.org/10.1111/iep.12242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743832PMC
October 2017
10 Reads

Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice.

Int J Exp Pathol 2017 12 11;98(6):329-340. Epub 2017 Dec 11.

Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.

Sepsis is associated with high mortality. Both critically ill humans and animal models of sepsis exhibit changes in their glucose homeostasis, that is, hypoglycaemia, with the progression of infection. However, the relationship between basal glycaemia, glucose tolerance and insulin sensitivity is not well understood. Read More

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http://dx.doi.org/10.1111/iep.12255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826970PMC
December 2017
5 Reads

Diets rich in saturated fat and fructose induce anxiety and depression-like behaviours in the rat: is there a role for lipid peroxidation?

Int J Exp Pathol 2017 10 6;98(5):296-306. Epub 2017 Dec 6.

Department of Pharmacology and Clinical Pharmacology and Therapeutics, Medical University of Varna, Varna, Bulgaria.

Epidemiological studies reveal associations between obesity/metabolic syndrome and mood disorders. We assessed behavioural changes in rats fed diets enriched in fat and fructose in different proportions and correlated the observed alterations with biochemical changes induced by the diets. Three groups of rats were used as follows: control (C) animals fed regular rat chow, rats fed high-fat diet (HF) and rats fed high-fat and high-fructose diet (HFHF). Read More

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http://dx.doi.org/10.1111/iep.12254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743787PMC
October 2017
6 Reads