24,162 results match your criteria International journal of cancer. Journal international du cancer[Journal]


Overweight and obesity during adolescence increases the risk of renal cell carcinoma.

Int J Cancer 2019 Feb 20. Epub 2019 Feb 20.

Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.

While overweight among adults has been linked with renal cell carcinoma (RCC) risk, little is known about the potential influence of overweight and obesity during adolescence. To ascertain if adolescent body mass index is associated with subsequent risk of RCC, we identified a cohort of 238,788 Swedish men who underwent mandatory military conscription assessment between 1969 and 1976 at a mean age of 18.5 years. Read More

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http://dx.doi.org/10.1002/ijc.32147DOI Listing
February 2019

Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant non-small cell lung cancer.

Int J Cancer 2019 Feb 20. Epub 2019 Feb 20.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau (SAR), China.

Oncogenic KRAS is considered a promising target for anti-cancer therapy. However, direct pharmacological strategies targeting KRAS-driven cancers remained unavailable. The prenyl-binding protein PDEδ, a transporter of KRAS, has been identified as a potential target for pharmacological inhibitor by selectively binding to its prenyl-binding pocket, impairing oncogenic KRAS signaling pathway. Read More

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http://dx.doi.org/10.1002/ijc.32222DOI Listing
February 2019

Human papillomavirus type 8 oncoproteins E6 and E7 cooperate in downregulation of the cellular checkpoint kinase-1.

Int J Cancer 2019 Feb 20. Epub 2019 Feb 20.

Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Fürst-Pückler-Str. 56, 50935 Cologne, Germany.

Human papillomavirus 8 (HPV8) is associated with the development of squamous cell carcinomas (SCC) of the skin. HPV-infected keratinocytes are able to over-ride normal checkpoint control mechanisms and sustain cell cycle activity, allowing for synthesis of cellular proteins necessary for viral genome amplification. To study how HPV8 may disrupt cell-cycle control, we analysed the impact of HPV8 early gene expression on one of the key regulators of cell cycle and DNA damage response, checkpoint kinase-1 (CHK1). Read More

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http://dx.doi.org/10.1002/ijc.32223DOI Listing
February 2019

Lymphotoxin-α promotes tumor angiogenesis in HNSCC by modulating glycolysis in a PFKFB3 dependent manner.

Int J Cancer 2019 Feb 20. Epub 2019 Feb 20.

Department of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.

Tumor angiogenesis is critical for tumor progression as the new blood vessels supply nutrients and facilitate metastasis. Previous studies indicate tumor associated lymphocytes, including B cells and T cells, contribute to tumor angiogenesis and tumor progression. The present study aims to identify the function of Lymphotoxin-α (LT-α), which is secreted by the activated lymphocytes, in the tumor angiogenesis of head and neck squamous cell carcinoma (HNSCC). Read More

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http://dx.doi.org/10.1002/ijc.32221DOI Listing
February 2019

EGFR-targeted therapy alters the tumor microenvironment in EGFR-driven lung tumors: Implications for combination therapies.

Int J Cancer 2019 Feb 5. Epub 2019 Feb 5.

Department of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, China.

Immune checkpoint inhibitors targeting the programmed cell death receptor/ligand 1 (PD-1/PD-L1) pathway have profoundly improved the clinical management of non-small-cell lung cancer (NSCLC). Nevertheless, the superiority of single-agent PD-1/PD-L1 inhibitors in pretreated EGFR mutant patients has turned out to be moderate. One proposed mechanism for poor response to immune checkpoint inhibitors is an immunosuppressive tumor microenvironment. Read More

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http://dx.doi.org/10.1002/ijc.32191DOI Listing
February 2019

Prospective Serum Metabolomic Profiling of Lethal Prostate Cancer.

Int J Cancer 2019 Feb 18. Epub 2019 Feb 18.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Impaired metabolism may play an important role in the pathogenesis of lethal prostate cancer, yet there is a paucity of evidence regarding the association. We conducted a large prospective serum metabolomic analysis of lethal prostate cancer in 523 cases and 523 matched controls nested within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Median time from baseline fasting serum collection to prostate cancer death was 18 years (maximum 30 years). Read More

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http://doi.wiley.com/10.1002/ijc.32218
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http://dx.doi.org/10.1002/ijc.32218DOI Listing
February 2019
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Identification of DNA mutations in gastric washes from gastric adenocarcinoma patients: possible implications for liquid biopsies and patient follow-up.

Int J Cancer 2019 Feb 18. Epub 2019 Feb 18.

Laboratory of Medical Genomics, A.C.Camargo Cancer Center, São Paulo, SP, Brazil.

Whereas cancer patients have benefited from liquid biopsies, the scenario for gastric adenocarcinoma (GAC) is still dismal. We used next-generation deep sequencing of TP53 - a highly mutated and informative gene in GAC - to assess mutations in tumor biopsies, plasma (PL) and stomach fluids (gastric wash - GW). We evaluated their potential to reveal tumor-derived mutations, useful for monitoring mutational dynamics at diagnosis, progression, and treatment. Read More

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http://dx.doi.org/10.1002/ijc.32217DOI Listing
February 2019

Genotyping of circulating cell-free DNA enables non-invasive tumor detection in myxoid liposarcomas.

Int J Cancer 2019 Feb 18. Epub 2019 Feb 18.

Department of Plastic and Hand Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Soft tissue sarcomas (STS) are rare tumors of mesenchymal origin. About 50% of patients with STS experience relapse and more than 30% will die within 10 years after diagnosis. In this study we investigated circulating free DNA (cfDNA) and tumor-specific genetic alterations therein (circulating tumor DNA, ctDNA) as diagnostic biomarkers. Read More

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http://dx.doi.org/10.1002/ijc.32216DOI Listing
February 2019

Subtraction of Epstein-Barr virus and microsatellite instability genotypes from the Lauren histotypes: combined molecular and histologic subtyping with clinicopathological and prognostic significance validated in a cohort of 1,248 cases.

Int J Cancer 2019 Feb 16. Epub 2019 Feb 16.

Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.

Limited studies investigated clinicopathological and prognostic significance of histologic and molecular subgroups of gastric cancer concurrently. We retrospectively enrolled 1,248 patients with gastric cancer who received radical gastrectomy with lymphadenectomy and classified these cases into the Epstein-Barr virus (EBV)-associated and microsatellite instability (MSI)-associated subtypes by EBV-encoded small RNA in situ hybridization and immunohistochemical stains for DNA mismatch repair proteins, respectively. The remaining cases were categorized as the Lauren intestinal and diffuse/mixed subtypes. Read More

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http://dx.doi.org/10.1002/ijc.32215DOI Listing
February 2019
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Mortality after breast cancer as a function of time since diagnosis by estrogen receptor status and age at diagnosis.

Int J Cancer 2019 Feb 16. Epub 2019 Feb 16.

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Melbourne, Victoria 3010, Australia.

Our aim was to estimate how long-term mortality following breast cancer diagnosis depends on age at diagnosis, tumor estrogen receptor (ER) status, and the time already survived. We used the population-based Australian Breast Cancer Family Study which followed-up 1,196 women enrolled during 1992-99 when aged <60 years at diagnosis with a first primary invasive breast cancer, over-sampled for younger ages at diagnosis, for whom tumor pathology features and ER status were measured. There were 375 deaths (median follow-up=15. Read More

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http://doi.wiley.com/10.1002/ijc.32214
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http://dx.doi.org/10.1002/ijc.32214DOI Listing
February 2019
4 Reads

Reply to letter: Thyroid neoplasia after Chernobyl: a comment.

Int J Cancer 2019 Feb 14. Epub 2019 Feb 14.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/ijc.32213DOI Listing
February 2019

Systematic reviews as a "lens of evidence": determinants of benefits and harms of breast cancer screening.

Int J Cancer 2019 Feb 14. Epub 2019 Feb 14.

Section of Early Detection and Prevention, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, France.

This systematic review, stimulated by inconsistency in secondary evidence, reports the benefits and harms of breast cancer (BC) screening and their determinants according to systematic reviews. A systematic search, which identified 9,976 abstracts, led to the inclusion of 58 reviews. BC mortality reduction with screening mammography was 15-25% in trials and 28-56% in observational studies in all age groups, and the risk of stage III+ cancers was reduced for women older than 49 years. Read More

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http://dx.doi.org/10.1002/ijc.32211DOI Listing
February 2019

Change in mammographic density across birth cohorts of Dutch breast cancer screening participants.

Int J Cancer 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology and Nuclear Medicine, Radboud University, Medical Center, Geert Grooteplein 10, 6525, GA, Nijmegen, the Netherlands.

High mammographic density is a well-known risk factor for breast cancer. This study aimed to search for a possible birth cohort effect on mammographic density, which might contribute to explain the increasing breast cancer incidence. We separately analysed left and right breast density of Dutch women from a 13-year period (2003-2016) in the breast cancer screening programme. Read More

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http://dx.doi.org/10.1002/ijc.32210DOI Listing
February 2019

Androgen receptor expression in circulating tumor cells of patients with metastatic breast cancer.

Int J Cancer 2019 Feb 13. Epub 2019 Feb 13.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus MC, Rotterdam, the Netherlands.

The androgen receptor (AR) has potential clinical relevance in metastatic breast cancer (mBC) since it might be a treatment target and has been associated with endocrine resistance. A minimal-invasive way to determine AR expression on metastatic tumor cells is by characterization of circulating tumor cells (CTCs). Here, we assessed AR mRNA expression in CTCs (CTC-AR) and in matched primary tumor samples from mBC patients representing different breast cancer subtypes. Read More

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http://dx.doi.org/10.1002/ijc.32209DOI Listing
February 2019

Highly-expressed P2X7 receptor promotes growth and metastasis of human HOS/MNNG osteosarcoma cells via PI3K/Akt/GSK3β/β-catenin and mTOR/HIF1α/VEGF signaling.

Int J Cancer 2019 Feb 13. Epub 2019 Feb 13.

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan 430030, China.

The P2X7 receptor, an ATP-gated ion channel, is critical for cancer cell growth, invasiveness, and angiogenesis. Previous studies indicate that P2X7 regulates osteoblast proliferation and osteodeposition and that high P2X7 expression has a pro-growth effect in osteosarcoma. However, how it functions in osteosarcoma cell growth and metastasis is not clear. Read More

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http://dx.doi.org/10.1002/ijc.32207DOI Listing
February 2019

Thyroid neoplasia after Chernobyl: a comment.

Authors:
Sergei V Jargin

Int J Cancer 2019 Feb 13. Epub 2019 Feb 13.

Rossijskij universitet druzby narodov, Clementovski per 6-82, Moscow, 115184, Russian Federation.

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http://dx.doi.org/10.1002/ijc.32208DOI Listing
February 2019

The impact of reducing alcohol consumption in Australia: an estimate of the proportion of potentially avoidable cancers 2013-2037.

Int J Cancer 2019 Feb 12. Epub 2019 Feb 12.

Population Health Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland 4006, Australia.

The International Agency for Research on Cancer first concluded that alcohol causes cancer in humans in 1988. The World Cancer Research Fund has declared that alcohol causes cancer of the oral cavity, pharynx, larynx, oesophagus (squamous cell carcinoma), female breast, colon, rectum, stomach and liver. It recommended that alcohol be avoided altogether to prevent cancer. Read More

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http://dx.doi.org/10.1002/ijc.32204DOI Listing
February 2019
2 Reads

Assessment and Management of Bone Health in Women with Early Breast Cancer Receiving Endocrine Treatment in the DATA Study.

Int J Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Medical Oncology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, the Netherlands.

The phase III DATA study investigates the efficacy of adjuvant anastrozole (6 versus 3 year) in postmenopausal women with breast cancer previously treated with 2-3 years of tamoxifen. This planned side-study assessed patterns of care regarding detection and treatment of osteopenia/osteoporosis, and trends in bone mineral density (BMD) during and after therapy. We registered all BMD measurements and bisphosphonate-use. Read More

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http://dx.doi.org/10.1002/ijc.32205DOI Listing
February 2019
2 Reads

Decoding genetic and epigenetic information embedded in cell free DNA with adapted SALP-seq.

Int J Cancer 2019 Feb 12. Epub 2019 Feb 12.

State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China.

Cell free DNA (cfDNA) in human plasma carries abundant information, which has therefore been the key sample for non-invasive prenatal testing (NIPT) and liquid biopsy. Especially by using the rapidly developed next-generation sequencing (NGS) techniques, the genetic and epigenetic information embedded in cfDNA has been effectively and extensively decoded. In this process, a key step is to construct the NGS library. Read More

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http://dx.doi.org/10.1002/ijc.32206DOI Listing
February 2019

Exploring a potential mechanistic role of DNA methylation in the relationship between in utero and post-natal environmental exposures and risk of childhood acute lymphoblastic leukaemia.

Int J Cancer 2019 Feb 10. Epub 2019 Feb 10.

Institute of Health & Society, Newcastle University, U.K.

The aetiology of childhood acute lymphoblastic leukaemia (ALL) is unclear. Genetic abnormalities have been identified in a number of ALL cases, although these alone are not sufficient for leukaemic transformation. Various in utero and post-natal environmental exposures have been suggested to alter risk of childhood ALL. Read More

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http://doi.wiley.com/10.1002/ijc.32203
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http://dx.doi.org/10.1002/ijc.32203DOI Listing
February 2019
2 Reads

Idelalisib for optimized CD19-specific chimeric antigen receptor T cells in chronic lymphocytic leukemia patients.

Int J Cancer 2019 Feb 9. Epub 2019 Feb 9.

Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.

Despite encouraging results with chimeric antigen receptor T (CART) cells, outcome can still be improved by optimization of the CART cell generation process. The proportion of less-differentiated T cells within the transfused product is linked to enhanced in vivo CART cell expansion and long-term persistence. The clinically approved PI3Kδ inhibitor idelalisib is well established in the treatment of B cell malignancies. Read More

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http://dx.doi.org/10.1002/ijc.32201DOI Listing
February 2019
1 Read

The expression of brown fat associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis.

Int J Cancer 2019 Feb 8. Epub 2019 Feb 8.

Pathology, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, AB25, 2ZD, UK.

Colorectal carcinoma is one of the most common types of malignancy and a leading cause of cancer related death. The aberrant expression of a brown fat-like phenotype in cancer cells has been previously implicated in tumour growth. Therefore, the expression of brown fat-associated proteins in colorectal cancer could be associated with tumour prognosis. Read More

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http://dx.doi.org/10.1002/ijc.32198DOI Listing
February 2019
1 Read

Cancer incidence and mortality among firefighters.

Int J Cancer 2019 Feb 8. Epub 2019 Feb 8.

Department of Research, Cancer Registry of Norway - Institute of Population-Based Cancer Research, Oslo, Norway.

Firefighters are exposed to both known and suspected carcinogens. This study aims to systematically review the literature on the association of firefighting occupation and cancer incidence and mortality, overall and for specific cancer sites. A systematic review using PubMed, Embase, and Web of Science was performed up to January 1, 2018. Read More

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http://dx.doi.org/10.1002/ijc.32199DOI Listing
February 2019
1 Read

Residential ambient benzene exposure in the United States and subsequent risk of hematologic malignancies.

Int J Cancer 2019 Feb 9. Epub 2019 Feb 9.

Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.

Benzene is considered a carcinogen, mostly based on evidence of causality for myeloid leukemia from high levels of exposure in occupational studies. We used U.S. Read More

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http://dx.doi.org/10.1002/ijc.32202DOI Listing
February 2019
1 Read

Targeting the TLK1/NEK1 DDR axis with Thioridazine suppresses outgrowth of Androgen Independent Prostate tumors.

Int J Cancer 2019 Feb 9. Epub 2019 Feb 9.

Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, USA.

Standard therapy for advanced Prostate Cancer (PCa) consists of anti-androgens, which provide respite from disease progression, but ultimately fail resulting in the incurable phase of the disease: mCRPC. Targeting PCa cells before their progression to mCRPC would greatly improve the outcome. Combination therapy targeting the DNA Damage Response (DDR) has been limited by general toxicity, and a goal of clinical trials is how to target the DDR more specifically. Read More

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http://dx.doi.org/10.1002/ijc.32200DOI Listing
February 2019
3 Reads

Recent increase in incidence of cervical precancerous lesions in Norway: nationwide study from 1992 to 2016.

Int J Cancer 2019 Feb 8. Epub 2019 Feb 8.

Department of Research, Cancer Registry of Norway, Oslo, Norway.

We analysed patterns in the incidence of cervical intraepithelial neoplasia grades 2 and 3 (CIN2, CIN3) and adenocarcinoma in situ (AIS) by age and histology in 1992-2016 in Norway and described changes in screening tests. Incident cases of CIN2, CIN3, AIS, and cervical cancer were identified in the Cancer Registry of Norway, as were all women with at least one screening test. The annual percentage change statistic was used to assess point estimates and changes in age-specific and age-standardised incidence rates (IR). Read More

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http://doi.wiley.com/10.1002/ijc.32195
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http://dx.doi.org/10.1002/ijc.32195DOI Listing
February 2019
4 Reads

In search of definitions: Cancer-associated fibroblasts and their markers.

Int J Cancer 2019 Feb 7. Epub 2019 Feb 7.

Molecular Disease Mechanisms Group, Life Sciences Research Unit, University of Luxembourg, 6 Avenue du Swing, L-4367 Campus Belval, Belvaux, Luxembourg.

The tumor microenvironment has been identified as one of the driving factors of tumor progression and invasion. Inside this microenvironment, cancer-associated fibroblasts (CAFs), a type of perpetually activated fibroblasts, have been implicated to have a strong tumor-modulating effect and play a key role in areas such as drug resistance. Identification of CAFs has typically been carried based on the expression of various "CAF markers", such as fibroblast activation protein alpha (FAP) and alpha smooth muscle actin (αSMA), which separates them from the larger pool of fibroblasts present in the body. Read More

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http://dx.doi.org/10.1002/ijc.32193DOI Listing
February 2019

Genetic variants in ELOVL2 and HSD17B12 predict melanoma-specific survival.

Int J Cancer 2019 Feb 8. Epub 2019 Feb 8.

Duke Cancer Institute, Duke University Medical Center, Durham, NC.

Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively assessed associations of 14,522 common single-nucleotide polymorphisms (SNPs) in 149 genes of the fatty-acid synthesis pathway with cutaneous melanoma disease-specific survival (CMSS). The dataset of 858 cutaneous melanoma (CM) patients from a published genome-wide association study (GWAS) by The University of Texas M. Read More

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http://dx.doi.org/10.1002/ijc.32194DOI Listing
February 2019
1 Read

Colorectal cancer exosomes induce lymphatic network remodeling in lymph nodes.

Int J Cancer 2019 Feb 8. Epub 2019 Feb 8.

Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.

The lymphatic network remodeling may guide tumor metastasis in a sentinel lymph node (SLN). Although tumor-derived exosomes have been demonstrated to modify the microenvironment in adjacent organs and initiate a premetastatic niche, their influence on the lymphatic network in SLNs has not been explained. Here, we show that CT26 cell exosomes (Exo) promote the proliferation of lymphatic endothelial cells and the formation of lymphatic network in SLN, facilitating the SLN metastasis of colorectal cancer (CRC). Read More

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http://dx.doi.org/10.1002/ijc.32196DOI Listing
February 2019
1 Read

Benign breast disease increases breast cancer risk independent of underlying familial risk profile: Findings from a Prospective Family Study Cohort.

Int J Cancer 2019 Feb 6. Epub 2019 Feb 6.

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.

Benign breast disease (BBD) is an established breast cancer (BC) risk factor, but it is unclear whether the magnitude of the association applies to women at familial or genetic risk. This information is needed to improve BC risk assessment in clinical settings. Using the Prospective Family Study Cohort, we used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of BBD with BC risk. Read More

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http://dx.doi.org/10.1002/ijc.32112DOI Listing
February 2019
2 Reads

Pediatric malignancies in neurofibromatosis type 1: A population-based cohort study.

Int J Cancer 2019 Feb 6. Epub 2019 Feb 6.

Institute of Biomedicine, University of Turku, Turku, Finland.

Neurofibromatosis type 1 (NF1) is a cancer predisposition syndrome with an incidence of 1:2,000. Patients with NF1 have an increased cancer risk and mortality, but there are no population-based cohort studies specifically investigating the risk of childhood malignancies. We used the Finnish NF1 cohort to analyze the incidence, risk and prognosis of malignancies in NF1 patients <20 years of age. Read More

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http://dx.doi.org/10.1002/ijc.32187DOI Listing
February 2019
2 Reads

H NMR-based metabolomics reveal overlapping discriminatory metabolites and metabolic pathway disturbances between colorectal tumor tissues and fecal samples.

Int J Cancer 2019 Feb 5. Epub 2019 Feb 5.

Radiology Department, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, Guangdong Province, China.

Previous studies have compared fecal metabolites from healthy and colorectal cancer (CRC) patients to predict the pro-CRC signatures. However, the systemic mechanistic link between feces and colonic tissues of CRC patients is still limited. The current study was a paralleled investigation of colonic tumor tissues and their normal adjacent tissues alongside patient-matched feces by using H nuclear magnetic resonance spectroscopy combined with pattern recognition to investigate how fecal metabolic phenotypes are linked to the changes in colorectal tumor profiles. Read More

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http://dx.doi.org/10.1002/ijc.32190DOI Listing
February 2019
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Molecular Alterations and Poziotinib Efficacy, a pan-HER inhibitor, in Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancers: Combined Exploratory Biomarker Analysis from a Phase II Clinical Trial of Poziotinib for Refractory HER2-positive Breast Cancer Patients.

Int J Cancer 2019 Feb 5. Epub 2019 Feb 5.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

We aimed to investigate the impact of genetic alterations on the efficacy of poziotinib in a phase II clinical trial of patients with heavily treated HER2-positive metastatic breast cancer (BC). We performed targeted ultra-deep sequencing with a customized cancer gene panel and RNA expression assay using BC specimens. Of 106 patients, biomarker data were available for 85. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32188
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http://dx.doi.org/10.1002/ijc.32188DOI Listing
February 2019
19 Reads

Transcriptome analysis of luminal breast cancer reveals a role for LOL in tumor progression and tamoxifen resistance.

Int J Cancer 2019 Feb 5. Epub 2019 Feb 5.

Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Luminal breast cancer (BC) has a sustained risk of late disease recurrence and death. Considerable numbers of patients suffer from antiendocrine therapy resistance. Here, we identified a novel lncRNA whose expression is high in breast cancer and especially higher in luminal breast cancer, dubbed LOL (lncRNA of luminal), that acts as a natural sponge for let-7 microRNAs to regulate tumor growth and tamoxifen resistance. Read More

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http://dx.doi.org/10.1002/ijc.32185DOI Listing
February 2019
2 Reads

Immuno-phenotypes of Pancreatic Ductal Adenocarcinoma: Meta-analysis of transcriptional subtypes.

Int J Cancer 2019 Feb 5. Epub 2019 Feb 5.

Department of Oncology, University of Oxford, Oxford, UK.

Pancreatic ductal adenocarcinoma (PDAC) is the most common malignancy of the pancreas and has one of the highest mortality rates of any cancer type with a 5-year survival rate of <5%. Recent studies of PDAC have provided several transcriptomic classifications based on separate analyses of individual patient cohorts. There is a need to provide a unified transcriptomic PDAC classification driven by therapeutically relevant biologic rationale to inform future treatment strategies. Read More

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http://dx.doi.org/10.1002/ijc.32186DOI Listing
February 2019

Prevalence and clinical outcomes of germline mutations in BRCA1/2 and PALB2 genes in 2769 unselected breast cancer patients in China.

Int J Cancer 2019 Feb 5. Epub 2019 Feb 5.

Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, Hangzhou, China.

To gain more information on the prevalence of germline mutations in BRCA1/2 and PALB2 genes in the Chinese population, and to explore the effects of the mutation status of these genes on clinical outcomes in patients with breast cancer, we performed a screening for BRCA1/2 and PALB2 mutations in a consecutive series of unselected breast cancer patients in the Chinese population. A total of 2,769 cases were enrolled between June 1993 and September 2017. All of the exons and exon-intron boundaries of the BRCA1/2 and PALB2 genes were screened with next-generation sequencing. Read More

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http://dx.doi.org/10.1002/ijc.32184DOI Listing
February 2019
1 Read

Heterogeneity in risk factors for ductal and lobular breast carcinomas: a case-control study.

Int J Cancer 2019 Feb 4. Epub 2019 Feb 4.

Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) of the breast are the most common histological subtypes of breast cancer. However, the associations and heterogeneity between histological subtypes and their risk factors are not well established. This study aimed to investigate risk factors for IDC and ILC. Read More

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http://dx.doi.org/10.1002/ijc.32182DOI Listing
February 2019
182 Reads
7.360 Impact Factor

Anlotinib, a novel small molecular tyrosine kinase inhibitor, suppresses growth and metastasis via dual blockade of VEGFR2 and MET in osteosarcoma.

Int J Cancer 2019 Feb 4. Epub 2019 Feb 4.

Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, with highly aggressive behavior and early systemic metastasis. The survival rates for osteosarcoma remain unchanged over the past two decades. Studies aiming to find new or alternative therapies for patients with refractory osteosarcoma are urgently needed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32180
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http://dx.doi.org/10.1002/ijc.32180DOI Listing
February 2019
9 Reads

Occurrence of human papillomavirus (HPV) type replacement by sexual risk-taking behaviour group: Post-hoc analysis of a community randomized clinical trial up to nine years after vaccination (IV).

Int J Cancer 2019 Feb 5. Epub 2019 Feb 5.

Faculty of Social Sciences, Tampere University, Finland.

Oncogenic non-vaccine human papillomavirus (HPV) types may conceivably fill the vacated ecological niche of the vaccine types. The likelihood of this may differ by the risk of acquiring HPV infections. We examined occurrence of HPV types among vaccinated and unvaccinated subgroups of 1992-1994 birth cohorts with differing acquisition risks up to 9 years post-implementation of HPV vaccination in 33 Finnish communities randomized to: Arm A (gender-neutral HPV16/18 vaccination), Arm B (girls-only HPV16/18 vaccination and hepatitis B-virus (HBV) vaccination of boys), and Arm C (gender-neutral HBV vaccination). Read More

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http://dx.doi.org/10.1002/ijc.32189DOI Listing
February 2019
1 Read

β1 Integrin is essential for fascin-mediated breast cancer stem cell function and disease progression.

Int J Cancer 2019 Feb 4. Epub 2019 Feb 4.

Stem Cell and Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Breast cancer remains the second cause of tumor-related mortality in women worldwide mainly due to chemoresistance and metastasis. The chemoresistance and metastasis are attributed to a rare subpopulation with enriched stem-like characteristics, thus called Cancer Stem Cells (CSCs). We have previously reported aberrant expression of the actin-bundling protein (fascin) in breast cancer cells, which enhances their chemoresistance, metastasis and enriches CSC population. Read More

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http://dx.doi.org/10.1002/ijc.32183DOI Listing
February 2019
1 Read

GITR ligation enhances functionality of tumor-infiltrating T cells in hepatocellular carcinoma.

Int J Cancer 2019 Feb 4. Epub 2019 Feb 4.

Departments of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.

No curative treatment options are available for advanced hepatocellular carcinoma (HCC). Anti-PD1 antibody therapy can induce tumor regression in 20% of advanced HCC patients, demonstrating that co-inhibitory immune checkpoint blockade has therapeutic potential for this type of cancer. However, whether agonistic targeting of co-stimulatory receptors might be able to stimulate anti-tumor immunity in HCC is as yet unknown. Read More

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http://dx.doi.org/10.1002/ijc.32181DOI Listing
February 2019
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Erratum: The efficacy and safety of anti-PD-1/PD-L1 antibodies combined with chemotherapy or CTLA4 antibody as a first-line treatment for advanced lung cancer.

Authors:
Bo Zhang Qiong Wu

Int J Cancer 2019 Apr 7;144(7):E2. Epub 2018 Dec 7.

Medical School of Nantong University, Nantong Shi, Jiangsu Sheng, People's Republic of China.

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http://dx.doi.org/10.1002/ijc.31820DOI Listing
April 2019
5.085 Impact Factor

Interaction between IGF2-PI3K axis and cancer-associated-fibroblasts promotes anal squamous carcinogenesis.

Int J Cancer 2019 Feb 4. Epub 2019 Feb 4.

Department of Translational Research, Institut Curie, PSL Research University, Paris, France.

Anal squamous cell carcinoma (ASCC) is a rare tumour, but its incidence is increasing. Standard chemoradiotherapy fails to cure 20% of patients and no targeted therapy is currently approved for recurrent ASCC. The PI3K/Akt/mTOR pathway is frequently altered in this poorly characterised carcinoma IGF2 was identified here as a key factor in ASCC oncogenesis, as IGF2 was shown to play a crucial role in the PI3K pathway with frequent (~60%) and mutually exclusive genomic alterations in IGF2, IGF1R, PTEN and PIK3CA genes. Read More

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http://dx.doi.org/10.1002/ijc.32178DOI Listing
February 2019
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Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.

Int J Cancer 2019 Feb 4. Epub 2019 Feb 4.

State Key Laboratory of Genetic Engineering, Zhongshan Hospital, Fudan University, and School of Life Sciences, Fudan University, Shanghai, 200438, China.

Glioma is the most common malignant primary brain tumors with poor prognosis. Genome wide association studies (GWAS) of glioma in populations with Western European ancestry were completed in the US and UK. However, our previous results strongly suggest the genetic heterogeneity could be important in glioma risk. Read More

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http://dx.doi.org/10.1002/ijc.32179DOI Listing
February 2019
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Targeted OMA1 therapies for cancer.

Authors:
Marcel V Alavi

Int J Cancer 2019 Feb 4. Epub 2019 Feb 4.

712 North Inc., San Francisco, CA.

The mitochondrial inner membrane proteins OMA1 and OPA1 belong to the BAX/BAK1-dependent apoptotic signaling pathway, which can be regulated by tumor protein p53 and the prohibitins PHB and PHB2 in the context of neoplastic disease. For the most part these proteins have been studied separate from each other. Here, I argue that the OMA1 mechanism of action represents the missing link between p53 and cytochrome c release. Read More

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http://dx.doi.org/10.1002/ijc.32177DOI Listing
February 2019

Germline variation in BRCA1/2 is highly ethnic-specific: Evidence from over 30,000 Chinese hereditary breast and ovarian cancer patients.

Int J Cancer 2019 Jan 31. Epub 2019 Jan 31.

Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, China.

BRCA1 and BRCA2 play essential roles in maintaining the genome stability. Pathogenic germline mutations in these two genes disrupt their function, lead to genome instability and increase the risk of developing breast and ovarian cancers. BRCA mutations have been extensively screened in Caucasian populations, and the resulting information are used globally as the standard reference in clinical diagnosis, treatment and prevention of BRCA-related cancers. Read More

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http://dx.doi.org/10.1002/ijc.32176DOI Listing
January 2019
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Prediagnostic serum organochlorine insecticide concentrations and primary liver cancer: A case-control study nested within two prospective cohorts.

Int J Cancer 2019 Jan 30. Epub 2019 Jan 30.

Cancer Registry of Norway, Institute of Population-based Cancer Research, Oslo, Norway.

Although experimental evidence indicates that certain organochlorine insecticides are hepatocarcinogens, epidemiologic evidence for most of these chemicals is very limited. We estimated associations, using prospectively collected sera, between organochlorine insecticide concentrations and cancer registry-identified primary liver cancer in two cohorts, one from the United States and one from Norway. In nested case-control studies, we used sera collected in the 1960s-1980s from 136 cases and 408 matched controls from the Kaiser Permanente Northern California Multiphasic Health Checkup (MHC) cohort and 84 cases and 252 matched controls from the population-based Norwegian Janus cohort. Read More

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http://dx.doi.org/10.1002/ijc.32175DOI Listing
January 2019

X chromosome-linked long noncoding RNA lnc-XLEC1 regulates c-Myc-dependent cell growth by collaborating with MBP-1 in endometrial cancer.

Int J Cancer 2019 Jan 30. Epub 2019 Jan 30.

Department of Genetics, Medical College of Soochow University, Suzhou 215123, China.

LncRNAs (long noncoding RNAs) are noncoding transcripts that are more than 200 nt long and have been described as the largest subclass in the noncoding transcriptome in humans. Although studies of lncRNAs in cancer have been continuing for a long time, no much has been known about X chromosome-linked lncRNAs. Here, by using RNA-seq we report the identification of a new X chromosome-linked lncRNA (lnc-XLEC1) that is aberrantly downregulated during the development of endometrial carcinoma (EC). Read More

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http://dx.doi.org/10.1002/ijc.32166DOI Listing
January 2019
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A novel and non-invasive approach utilising nasal washings for the detection of nasopharyngeal carcinoma.

Int J Cancer 2019 Jan 30. Epub 2019 Jan 30.

Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, Ministry of Health Malaysia, Kuala Lumpur, Malaysia.

Nasopharyngeal carcinoma (NPC) is an epithelial cancer of the nasopharynx which is highly associated with Epstein-Barr virus (EBV). Worldwide, most of the top 20 countries with the highest incidence and mortality rates of NPC are low- and middle-income countries. Many studies had demonstrated that EBV could be detected in the tissue, serum and plasma of NPC patients. Read More

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http://doi.wiley.com/10.1002/ijc.32173
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http://dx.doi.org/10.1002/ijc.32173DOI Listing
January 2019
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Human papillomavirus and p16 immunostaining, prevalence and prognosis of squamous carcinoma of unknown primary in the head and neck region.

Int J Cancer 2019 Jan 30. Epub 2019 Jan 30.

Medical Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.

The prevalence of human papillomavirus (HPV) in squamous cell carcinoma of unknown primary in the head and neck (SCCUPHN), and prognosis by HPV status of SCCUPHN patients has been difficult to estimate because of the rarity of this subtype. In MEDLINE, Epub Ahead of Print, In-Process & Other Non-Indexed Citations, EMBASE, Cochrane library and Web of Science searches, observational studies and clinical trials that reported survival rates of patients with SCCUPHN by HPV status were identified. Meta-analysis estimated the prevalence and prognosis (overall survival, OS; progression-free survival, PFS) of SCCUPHN by HPV status, and compared them to studies of oropharyngeal squamous cell carcinoma (OPSCC) from the same institutions and across continents. Read More

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http://doi.wiley.com/10.1002/ijc.32164
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http://dx.doi.org/10.1002/ijc.32164DOI Listing
January 2019
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