24,286 results match your criteria International journal of cancer. Journal international du cancer[Journal]


Reply to: "Design flaws in statins and pancreatic cancer research".

Int J Cancer 2019 Apr 17. Epub 2019 Apr 17.

Department of Clinical Epidemiology, Aarhus University Hospital, Denmark.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32349
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April 2019
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REBACIN® as a Non-invasive Clinical Intervention for High-Risk Human Papillomavirus Persistent Infection.

Int J Cancer 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynaecology, Peking Union Medical College Hospital, Beijing, China.

The development of highly sensitive HPV-genotyping tests has opened the possibility of treating HPV-infected women before high-grade lesions appear. The lack of efficient intervention for persistent high risk HPV infection necessitates the need for development of novel therapeutic strategy. Here we demonstrate that REBACIN®, a proprietary anti-viral biologics, has shown potent efficacy in the clearance of persistent HPV infections. Read More

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http://dx.doi.org/10.1002/ijc.32344DOI Listing

Beyond the tumour microenvironment.

Int J Cancer 2019 Apr 16. Epub 2019 Apr 16.

CNRS UMR8590, Institute for History and Philosophy of Science and Techniques, Paris, France.

In contrast to the once dominant tumour-centric view of cancer, increasing attention is now being paid to the tumour microenvironment (TME), generally understood as the elements spatially located in the vicinity of the tumour. Thinking in terms of TME has proven extremely useful, in particular because it has helped identify and comprehend the role of non-genetic and non-cell-intrinsic factors in cancer development. Yet some current approaches have led to a TME-centric view, which is no less problematic than the former tumour-centric vision of cancer, insofar as it tends to overlook the role of components located beyond the TME, in the "tumour organismal environment" (TOE). Read More

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http://dx.doi.org/10.1002/ijc.32343DOI Listing

Comment on "A Prospective Study of Tea Drinking Temperature.." by Islami et al.

Authors:
Dinesh Ranjan

Int J Cancer 2019 Apr 16. Epub 2019 Apr 16.

193 Heavens Gate Lane, Roseburg, Oregon 97471.

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http://dx.doi.org/10.1002/ijc.32345DOI Listing

Use of fertility drugs in early onset female cancer survivors -A Finnish register-based study on 8,929 survivors.

Int J Cancer 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.

Advances in multimodality cancer treatments have increased the risk of long-term complications in early onset cancer survivors. For female cancer survivors these include diminished reproductive function, often resulting in a narrowed fertile window. The aim of this study was to evaluate the use of fertility treatments in cancer survivors (aged 0-39 years at diagnosis) compared to siblings. Read More

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http://dx.doi.org/10.1002/ijc.32346DOI Listing

Reply to: "Letter to the editors regarding recent publication by Islami, F. et al."

Int J Cancer 2019 Apr 16. Epub 2019 Apr 16.

Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32342
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April 2019
1 Read
5.085 Impact Factor

Cervical Adenocarcinoma in Situ: Human Papillomavirus Types and Incidence Trends in Five States, 2008-2015.

Int J Cancer 2019 Apr 13. Epub 2019 Apr 13.

Centers for Disease Control and Prevention, Atlanta, Georgia, United States.

Primary prevention through the use of human papillomavirus (HPV) vaccination is expected to impact both cervical intraepithelial neoplasia (CIN) and adenocarcinoma in situ (AIS). While CIN is well described, less is known about the epidemiology of AIS, a rare cervical precancer. We identified AIS and CIN grade 3 (CIN3) cases through population-based surveillance, and analyzed data on HPV types and incidence trends overall, and among women screened for cervical cancer. Read More

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http://dx.doi.org/10.1002/ijc.32340DOI Listing

Hospital admission for neurologic disorders among five-year survivors of non-central nervous system tumors in childhood: a cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study.

Int J Cancer 2019 Apr 13. Epub 2019 Apr 13.

Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark.

Large, comprehensive studies of the risk for neurologic disorders among long-term survivors of non-central nervous system (CNS) childhood cancers are lacking. Thus, the aim of this study was to assess the lifetime risk of Nordic non-CNS childhood cancer survivors for neurologic disorders. We identified 15,967 five-year survivors of non-CNS childhood cancer diagnosed in Denmark, Iceland, Finland, and Sweden in 1943-2008, and 151,118 matched population comparison subjects. Read More

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http://dx.doi.org/10.1002/ijc.32341DOI Listing

Overuse of anti-anaerobic drug is associated with poor post-chemotherapy prognosis of patients with hepatocellular carcinoma.

Int J Cancer 2019 Apr 13. Epub 2019 Apr 13.

Department of Gastroenterology, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, Japan 9208641.

Overuse of antibiotic drugs alters the composition of gut microbiota and has detrimental effects on the host. In this study, we investigated association of gut flora and antibiotics in the prognosis of patients with liver cancer who have undergone chemotherapy by analyzing two independent clinical studies. We retrospectively sub-analyzed a previously reported randomized controlled trial (RCT) on hepatic arterial infusion chemotherapy in patients with hepatocellular carcinoma (HCC) to investigate the association between use of antibiotics and prognosis. Read More

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http://dx.doi.org/10.1002/ijc.32339DOI Listing

RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer.

Int J Cancer 2019 Apr 13. Epub 2019 Apr 13.

Cancer Progression Center of Excellence, National Yang-Ming University, Taipei, Taiwan.

The dynamic cell-cell communication is essential for tissue homeostasis in normal physiological circumstances and contributes to a diversified tumor microenvironment (TME). Although exosomes are extracellular vesicles (EVs) that actively participate in cell-cell interaction by shutting cellular components, impacts of tumor exosomes in the context of cancer stemness remain elusive. Here, we expand colorectal cancer stem cells (CRCSCs) as cancer spheroids and demonstrate that the β-catenin/Tcf-4-activated RAB27B expression is required for the secretion of CRCSC exosomes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32338
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April 2019
3 Reads

Use of metformin and outcome of patients with newly diagnosed glioblastoma - pooled analysis.

Int J Cancer 2019 Apr 13. Epub 2019 Apr 13.

Department of Neurology and Wilhelm Sander-NeuroOncology Unit, Regensburg University Hospital, Regensburg, Germany.

Metformin has been linked to improved survival of patients with various cancers. There is little information on survival of glioblastoma patients after use of metformin. We assessed the association between metformin use and survival in a pooled analysis of patient data from 1,731 individuals from the randomized AVAGlio, CENTRIC and CORE trials. Read More

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http://dx.doi.org/10.1002/ijc.32337DOI Listing

Perinatal and familial risk factors for soft tissue sarcomas in childhood through young adulthood: A population-based assessment in 4 million live births.

Int J Cancer 2019 Apr 13. Epub 2019 Apr 13.

Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.

Perinatal factors have been associated with soft tissue sarcomas (STS) in case-control studies. However, (1) the contributions of factors including fetal growth remain unknown, (2) these factors have not been examined in cohort studies, and (3) few assessments have evaluated risk in specific STS subtypes. We sought to identify the role of perinatal and familial factors on the risk of STS in a large population-based birth cohort. Read More

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http://dx.doi.org/10.1002/ijc.32335DOI Listing

Crumbs3 is a critical factor that regulates invasion and metastasis of colon adenocarcinoma via the specific interaction with FGFR1.

Int J Cancer 2019 Apr 13. Epub 2019 Apr 13.

Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Epithelial cell polarity regulator Crumbs3 (Crb3), a mammalian homolog within the Drosophila Crb gene family, was initially identified as an essential embryonic development factor. It is recently implicated in tumor suppression, though its specific functions are controversial. We here demonstrate that Crb3 strongly promotes tumor invasion and metastasis of human colon adenocarcinoma cells. Read More

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http://dx.doi.org/10.1002/ijc.32336DOI Listing

A bronchial-airway gene-expression classifier to improve the diagnosis of lung cancer: clinical outcomes and cost-effectiveness analysis.

Int J Cancer 2019 Apr 11. Epub 2019 Apr 11.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America.

Bronchoscopy is the safest procedure for lung cancer diagnosis when an invasive evaluation is required after imaging procedures. However its sensitivity is relatively low, especially for small and peripheral lesions. We assessed benefits and costs of introducing a bronchial gene-expression classifier (BGC) to improve the performance of bronchoscopy and the overall diagnostic process for early detection of lung cancer. Read More

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http://dx.doi.org/10.1002/ijc.32333DOI Listing

SET domain containing 1B gene (SETD1B) is mutated in primary hepatic neuroendocrine tumors.

Int J Cancer 2019 Apr 11. Epub 2019 Apr 11.

Beijing 302 Hospital/5th Medical Center of Chinese PLA General of Hospital, Beijing 100039, China.

Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare NETs originating from the liver. These tumors are associated with heterogeneous prognosis, and few treatment targets for PHNETs have been identified. Because the major genetic alterations in PHNET are still largely unknown, we performed whole-exome sequencing of 22 paired tissues from PHNET patients and identified 22 recurring mutations of somatic genes involved in the following activities: epigenetic modification (BPTF, MECP2 and WDR5), cell cycle (TP53, ATM, MED12, DIDO1 and ATAD5) and neural development (UBR4, MEN1, GLUL and GIGYF2). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32334
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April 2019
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Significant inter- and intra-laboratory variation in grading of invasive breast cancer: a nationwide study of 33,043 patients in the Netherlands.

Int J Cancer 2019 Apr 11. Epub 2019 Apr 11.

Foundation PALGA (the nationwide network and registry of histo- and cytopathology in the Netherlands), Houten, the Netherlands.

Accurate, consistent, and reproducible grading by pathologists is of key-importance for identification of individual patients with invasive breast cancer (IBC) that will or will not benefit from adjuvant systemic treatment. We studied the laboratory-specific grading variation using nationwide real-life data to create insight and awareness in grading variation. Synoptic pathology reports of all IBC resection-specimens, obtained between 2013-2016, were retrieved from the nationwide Dutch Pathology Registry (PALGA). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32330
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http://dx.doi.org/10.1002/ijc.32330DOI Listing
April 2019
3 Reads

U2-related proteins CHERP and SR140 contribute to colorectal tumorigenesis via alternative splicing regulation.

Int J Cancer 2019 Apr 11. Epub 2019 Apr 11.

CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

Dysregulation of CHERP has been implicated in several cancers, but it remains elusive how CHERP contributes to cancer cell proliferation and cancer development. Here, we observed that CHERP and its binding partner SR140 are significantly upregulated in human clinical colorectal cancer tissues (CRC). CHERP and SR140 could form a protein complex to stabilize each other. Read More

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http://dx.doi.org/10.1002/ijc.32331DOI Listing

Integration of whole-genome sequencing and functional screening identifies a prognostic signature for lung metastasis in triple-negative breast cancer.

Int J Cancer 2019 Apr 11. Epub 2019 Apr 11.

Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University.

Lung metastasis is one of the leading causes of death for triple-negative breast cancer (TNBC). We sought to characterize the genetic alterations underlying TNBC lung metastases by integrating whole-genome sequencing and functional screening. Further, we aimed to develop a metastasis-related gene signature for TNBC patients to improve risk stratification. Read More

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http://dx.doi.org/10.1002/ijc.32329DOI Listing
April 2019
1 Read

Mutagenicity of Helicobacter hepaticus infection in the lower bowel mucosa of 129/SvEv Rag2 Il10 gpt delta mice is influenced by sex.

Int J Cancer 2019 Apr 11. Epub 2019 Apr 11.

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Inflammatory bowel disease and colonic tumors induced by Helicobacter hepaticus (Hh) infection in susceptible mouse strains are utilized to dissect the mechanisms underlying similar human diseases. In this study, infection with genotoxic cytolethal distending toxin-producing Hh in 129/SvEv Rag2 Il10 gpt delta (RagIl10gpt) mice of both sexes for 21 weeks induced significantly more severe cecal and colonic pathology compared to uninfected controls. The mutation frequencies in the infected RagIl10gpt males were 2. Read More

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http://dx.doi.org/10.1002/ijc.32332DOI Listing

The effects of erythropoiesis-stimulating agents on the management of chemotherapy-induced anemia and tumor growth in diffuse large B-cell lymphoma patients.

Int J Cancer 2019 Apr 11. Epub 2019 Apr 11.

Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea.

Erythropoiesis-stimulating agents (ESAs), such as erythropoietin (EPO) and darbepoetin, may alleviate anemia in diffuse large B-cell lymphoma (DLBCL) patients. However, many cancer cells express EPO receptors (EPOR), through which exogenously-administered ESAs potentially promote cancer cell growth. We conducted preclinical/phase II studies to investigate the safety and efficacy of ESAs for managing chemotherapy-related anemia in DLBCL patients. Read More

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http://dx.doi.org/10.1002/ijc.32328DOI Listing
April 2019
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RNA sequencing reveals PNN and KCNQ1OT1as predictive biomarkers of clinical outcome in stage III colorectal cancer patients treated with adjuvant chemotherapy.

Int J Cancer 2019 Apr 11. Epub 2019 Apr 11.

Department of Health Sciences, University of Florence, Florence, Italy.

5-year overall survival of stage III colorectal cancer (CRC) patients treated with standard adjuvant chemotherapy (ACHT) is highly variable. Genomic biomarkers and/or transcriptomic profiles identified lack of adequate validation. Aim of this study was to identify and validate molecular biomarkers predictive of ACHT response in stage III CRC patients by a transcriptomic approach. Read More

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http://dx.doi.org/10.1002/ijc.32326DOI Listing

The predictive power of tumor mutational burden in lung cancer immunotherapy response is influenced by patients' sex.

Int J Cancer 2019 Apr 10. Epub 2019 Apr 10.

School of Life Science and Technology, ShanghaiTech University, Shanghai 201203, China.

Immunotherapy, represented by immune checkpoint inhibitors (ICI), is transforming the treatment of cancer. However, only a fraction of patients show response to ICI, and there is an unmet need for biomarkers that will identify patients more likely to respond to ICI. Here we report that the ICI response prediction biomarker tumor mutational burden (TMB) shows significant sex differences. Read More

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http://dx.doi.org/10.1002/ijc.32327DOI Listing
April 2019
2 Reads

Oncolytic virotherapy enhances the efficacy of a cancer vaccine by modulating the tumor microenvironment.

Int J Cancer 2019 Apr 10. Epub 2019 Apr 10.

Division of Virology, Medical University of Innsbruck, Austria.

The efficacy of cancer vaccines has been limited by the immunosuppressive tumor microenvironment, which can be alleviated by immune checkpoint inhibitor (ICI) therapy. Here, we tested if oncolytic viruses, similar to ICI, can also synergize with cancer vaccines by modulating the tumor microenvironment. VSV-GP, a chimeric vesicular stomatitis virus (VSV) pseudotyped with the glycoprotein of the lymphocytic choriomeningitis virus, is a promising new oncolytic virus candidate. Read More

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http://dx.doi.org/10.1002/ijc.32325DOI Listing
April 2019
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BRCA1 and EZH2 cooperate in regulation of prostate cancer stem cell phenotype.

Int J Cancer 2019 Apr 10. Epub 2019 Apr 10.

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University; Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Dresden; Germany; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology-OncoRay, Dresden, Germany; German Cancer Consortium (DKTK), partner site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Prostate cancer (PCa) is the second most common malignancy and the sixth leading cause of cancer-related death among men worldwide. Prostate carcinogenesis is driven by the accumulation of genetic and epigenetic aberrations, which regulate cancer cell transition between a stem- and non-stem-cell state and accelerate tumor evolution. Elevated expression of enhancer of zeste homolog 2 (EZH2) histone methyltransferase, a core member of the polycomb repressive complex 2 (PRC2), results in cancer progression through histone methylation-driven tumor cells de-differentiation. Read More

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http://dx.doi.org/10.1002/ijc.32323DOI Listing

Mediation analysis of the alcohol-postmenopausal breast cancer relationship by sex hormones in the EPIC Cohort.

Int J Cancer 2019 Apr 10. Epub 2019 Apr 10.

Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69008 Lyon, France.

Alcohol consumption is associated with higher risk of breast cancer (BC); however, the biological mechanisms underlying this association are not fully elucidated, particularly the extent to which this relationship is mediated by sex hormone levels. Circulating concentrations of estradiol, testosterone, their free fractions and sex-hormone binding globulin (SHBG), were examined in 430 incident BC cases and 645 matched controls among alcohol-consuming postmenopausal women nested within the European Prospective Investigation into Cancer and Nutrition. Mediation analysis was applied to assess whether individual hormone levels mediated the relationship between alcohol intake and BC risk. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32324
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http://dx.doi.org/10.1002/ijc.32324DOI Listing
April 2019
5 Reads

The influence of birth cohort and calendar period on global trends in ovarian cancer incidence.

Int J Cancer 2019 Apr 10. Epub 2019 Apr 10.

Section of Cancer Surveillance, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, France.

Ovarian cancer is the eighth most common cancer in women worldwide and incidence rates vary markedly by world region. This study provides a comprehensive overview of ovarian cancer incidence trends globally, examining the influence of birth cohort and period of diagnosis on changing risk. We presented current patterns and trends of ovarian cancer incidence until 2012 using data from successive volumes of Cancer Incidence in Five Contents. Read More

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http://dx.doi.org/10.1002/ijc.32322DOI Listing
April 2019
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Glioma risk associated with extent of estimated European genetic ancestry in African-Americans and Hispanics.

Int J Cancer 2019 Apr 9. Epub 2019 Apr 9.

Department of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Glioma incidence is highest in non-Hispanic Whites, and to date, glioma genome-wide association studies (GWAS) to date have only included European ancestry (EA) populations. African-Americans and Hispanics in the US have varying proportions of EA, African (AA) and Native American ancestries (NAA). It is unknown if identified GWAS loci or increased EA is associated with increased glioma risk. Read More

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http://dx.doi.org/10.1002/ijc.32318DOI Listing

Comparative genetic profiling aids diagnosis and clinical decision making in challenging cases of CUP syndrome.

Int J Cancer 2019 Apr 9. Epub 2019 Apr 9.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Cancer of unknown primary (CUP) denotes cancer cases where metastatic spread is histologically confirmed, but no respective primary tumor can be identified. The challenging diagnosis of CUP is further complicated in cases with previously identified malignancies or with dubious clonal relationship between metastatic sites due to ambiguous histology. This study aims at elucidating clonal relationships by comparing the respective mutational spectra. Read More

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http://dx.doi.org/10.1002/ijc.32316DOI Listing

Non-V600E BRAF mutations and EGFR signaling pathway in colorectal cancer.

Int J Cancer 2019 Apr 9. Epub 2019 Apr 9.

Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

The BRAF mutation (MT) in metastatic colorectal cancer (CRC) is a well-known prognostic indicator and a negative predictive biomarker for anti-epidermal growth factor receptor (EGFR) treatment. However, the clinical characteristics and significance of BRAF MTs remain unclear. Here, we evaluated the clinical characteristics of BRAF MTs versus those of other MTs in the EGFR signaling pathway, including BRAF . Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32320
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http://dx.doi.org/10.1002/ijc.32320DOI Listing
April 2019
3 Reads

Long non-coding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15.

Int J Cancer 2019 Apr 9. Epub 2019 Apr 9.

Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan 40402.

The long non-coding RNA HOTAIR plays significant roles in promoting cancer metastasis. However how it conveys invasive advantage in cancer cells is not clear. Here we identify the chondroitin sulfotransferase CHST15 (GalNAc4S-6ST) as a novel HOTAIR target gene using RNA profiling and show that CHST15 is required for HOTAIR-mediated invasiveness in breast cancer cells. Read More

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http://dx.doi.org/10.1002/ijc.32319DOI Listing

MKK7 transcription positively or negatively regulated by SP1 and KLF5 depends on HDAC4 activity in glioma.

Int J Cancer 2019 Apr 9. Epub 2019 Apr 9.

Department of Neurosurgery and Neurosurgical Disease Research Centre, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.

JNK activity has been implicated in the malignant proliferation, invasion and drug-resistance of glioma cells (GCs), but the molecular mechanisms underlying JNK activation are currently unknown. Here, we reported that MKK7, not MKK4, directly activates JNK in GCs and exerts oncogenic effects on tumour formation. Notably, MKK7 expression in glioma tissues was closely correlated with the grade of the glioma and JNK/c-Jun activation. Read More

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http://dx.doi.org/10.1002/ijc.32321DOI Listing

HPV73 a non-vaccine type causes cervical cancer.

Int J Cancer 2019 Apr 9. Epub 2019 Apr 9.

Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Ave, Ullmann Building, Room 515, Bronx 10461, New York, USA.

HPV73 is classified as possibly oncogenic. It is neither routinely evaluated in HPV screening, nor covered by any of the prophylactic vaccines. We sought to investigate the carcinogenic characteristics of HPV73. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32315
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http://dx.doi.org/10.1002/ijc.32315DOI Listing
April 2019
2 Reads

A phase 1b study evaluating the safety and pharmacokinetics of regorafenib in combination with cetuximab in patients with advanced solid tumors.

Int J Cancer 2019 Apr 8. Epub 2019 Apr 8.

University of Southern California/Norris Comprehensive Center, Los Angeles, CA.

Regorafenib 160 mg orally once daily (QD) 3 weeks on/1 week off is approved in colorectal cancer, gastrointestinal stromal tumors, and hepatocellular carcinoma. We established the safety and pharmacokinetics (PK) of regorafenib combined with cetuximab in advanced refractory solid tumors. This was a phase 1, open-label, dose-escalation study (NCT01973868) in patients with advanced/metastatic solid tumors who progressed after standard therapy. Read More

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http://dx.doi.org/10.1002/ijc.32317DOI Listing
April 2019
1 Read

EPHA2 blockade reverses acquired resistance to afatinib induced by EPHA2-mediated MAPK pathway activation in gastric cancer cells and avatar mice.

Int J Cancer 2019 Apr 7. Epub 2019 Apr 7.

Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, China.

Afatinib is a pan-HER inhibitor approved for specific types of lung cancer. We explored antitumor activity, predictive biomarkers and the potential mechanisms underlying antitumor effect and acquired resistance of afatinib in gastric cancer (GC) in vitro and in vivo. Five human GC cell lines and eight patient-derived xenograft (PDX) models with clear molecular profiling were used to evaluate the antitumor activity and mechanisms of afatinib. Read More

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http://dx.doi.org/10.1002/ijc.32313DOI Listing

Erratum.

Authors:

Int J Cancer 2019 Jun 7;144(11):E7. Epub 2019 Feb 7.

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http://dx.doi.org/10.1002/ijc.32192DOI Listing

Patterns in metabolite profile are associated with risk of more aggressive prostate cancer: a prospective study of 3057 matched case-control sets from EPIC.

Int J Cancer 2019 Apr 5. Epub 2019 Apr 5.

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

Metabolomics may reveal novel insights into the aetiology of prostate cancer, for which few risk factors are established. We investigated the association between patterns in baseline plasma metabolite profile and subsequent prostate cancer risk, using data from 3057 matched case-control sets from the European Prospective Investigation into Cancer and Nutrition (EPIC). We measured 119 metabolite concentrations in plasma samples, collected on average 9. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32314
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http://dx.doi.org/10.1002/ijc.32314DOI Listing
April 2019
1 Read
5.085 Impact Factor

Claudin7-dependent exosome-promoted reprogramming of non-metastasizing tumor cells.

Int J Cancer 2019 Apr 4. Epub 2019 Apr 4.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany.

Claudin7 (cld7) is a cancer-initiating cell (CIC) marker in gastrointestinal tumors, a cld7-knockdown (kd) being accompanied by loss of tumor progression. Tumor-exosomes (TEX) restoring CIC activities, we explored the contribution of cld7. This became particularly interesting, as tight junction (TJ)- and glycolipid-enriched membrane domain (GEM)-derived cld7 is recruited into distinct TEX. Read More

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http://dx.doi.org/10.1002/ijc.32312DOI Listing

Circular RNA CEP128 Promotes Bladder Cancer Progression by Regulating Mir-145-5p/Myd88 Via Mapk Signaling Pathway.

Int J Cancer 2019 Apr 2. Epub 2019 Apr 2.

Department of Urology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China.

The present experiment was designed for exploring the regulatory mechanism of circ-CEP128/miR-145-5p/MYD88 axis in bladder cancer. MiRNAs and circRNAs expression data were derived from Gene Expression Omnibus database (GEO) with bladder tumor tissues and para-carcinoma tissue samples. Differentially expressed genes (DEGs) in tumor were analyzed via R software. Read More

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http://dx.doi.org/10.1002/ijc.32311DOI Listing

Diabetes and Cancer Risk: A Mendelian Randomization Study.

Int J Cancer 2019 Mar 30. Epub 2019 Mar 30.

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.

Earlier cohort studies using conventional regression models have consistently shown an increased cancer risk among individuals with type 2 diabetes. However, reverse causality and residual confounding due to common risk factors could exist, and it remains unclear whether diabetes per se contributes to cancer development. Mendelian randomization analyses might clarify the true association between diabetes and cancer risk. Read More

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http://dx.doi.org/10.1002/ijc.32310DOI Listing

Opportunistic testing of BRCA1, BRCA2 and mismatch repair genes improves the yield of phenotype driven hereditary cancer gene panels.

Int J Cancer 2019 Mar 29. Epub 2019 Mar 29.

High Risk and Familial Cancer, Vall d'Hebron Institute of Oncology, Barcelona.

Multigene panels provide a powerful tool for analyzing several genes simultaneously. We evaluated the frequency of pathogenic variants (PV) in customized predefined panels according to clinical suspicion by phenotype and compared it to the yield obtained in the analysis of our clinical research gene panel. We also investigated mutational yield of opportunistic testing of BRCA1/2 and mismatch repair (MMR) genes in all patients. Read More

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http://dx.doi.org/10.1002/ijc.32304DOI Listing
March 2019
3 Reads

Recurrent moderate-risk mutations in Finnish breast and ovarian cancer patients.

Int J Cancer 2019 Mar 30. Epub 2019 Mar 30.

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Mutations in BRCA1 and BRCA2 genes predispose to breast and ovarian cancer with a high lifetime risk, whereas mutations in PALB2, CHEK2, ATM, FANCM, RAD51C, and RAD51D genes cause a moderately elevated risk. In the Finnish population, recurrent mutations have been identified in all of these genes, the latest being CHEK2 c.319+2T>A and c. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32309
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http://dx.doi.org/10.1002/ijc.32309DOI Listing
March 2019
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The systemic immune-inflammation index is associated with an increased risk of incident cancer-A population-based cohort study.

Int J Cancer 2019 Mar 28. Epub 2019 Mar 28.

Department of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Several studies found that the systemic immune-inflammation index (SII) is a prognostic factor for mortality in patients with solid tumors. It is unknown whether an increased SII in generally healthy individuals reflects a risk for developing cancer. Our objective was to investigate the association between the SII and incident cancers in a prospective cohort study. Read More

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http://dx.doi.org/10.1002/ijc.32303DOI Listing

Association between ambient air pollution and breast cancer risk: The Multiethnic Cohort Study.

Int J Cancer 2019 Mar 28. Epub 2019 Mar 28.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Previous studies using different exposure methods to assess air pollution and breast cancer risk among primarily whites have been inconclusive. Air pollutant exposures of particulate matter and oxides of nitrogen were estimated by kriging (NO , NO , PM , PM ), land use regression (LUR, NO , NO ), and California Line Source Dispersion Model (CALINE4, NO , PM ) for 57,589 females from the Multiethnic Cohort, residing largely in Los Angeles County from recruitment (1993-1996) through 2010. Cox proportional hazards models were used to examine the associations between time-varying air pollution and breast cancer incidence adjusting for confounding factors. Read More

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http://dx.doi.org/10.1002/ijc.32308DOI Listing

Sarcomas in patients over 90: Natural history and treatment-A nationwide study over 6 years.

Int J Cancer 2019 Mar 28. Epub 2019 Mar 28.

Centre Léon Bérard, University Claude Bernard Lyon I, Lyon, France.

Soft tissue sarcomas (STS) are rare tumors accounting for less than 1% of human cancers. While the highest incidence of sarcomas is observed in elderly, this population is often excluded or poorly represented in clinical trials. The present study reports on clinicopathological presentation, and outcome of sarcoma patients over 90 recorded in the Netsarc. Read More

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http://dx.doi.org/10.1002/ijc.32307DOI Listing
March 2019
5.085 Impact Factor

Lymph node metastasis in oral cancer is strongly associated with chromosomal instability and DNA repair defects.

Int J Cancer 2019 Mar 28. Epub 2019 Mar 28.

National Institute of Biomedical Genomics, Netaji Subhas Sanatorium, Kalyani, West Bengal, India.

Oral squamous cell carcinoma (OSCC) is highly prevalent in south and southeast Asia. Many (30-50%) OSCC patients develop lymph node metastasis (LNM), which is the most important prognostic factor in OSCC. To identify genomic correlates of LNM, we compared exome sequences and copy number variation data of blood and tumor DNA from highly contrasting subgroups of patients to reduce false inferences-(i) patients with LNM and (ii) patients with late stage disease but without LNM. Read More

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http://dx.doi.org/10.1002/ijc.32305DOI Listing

Fibulin-7 is overexpressed in glioblastomas and modulates glioblastoma neovascularization through interaction with angiopoietin-1.

Int J Cancer 2019 Mar 28. Epub 2019 Mar 28.

Department of Pathophysiology for Locomotive and Neoplastic Diseases, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Glioblastoma (GBM) is pathologically characterized by highly malignant neoplastic cells, focal necrosis and aberrant blood vessels composed of disorganized endothelial cells and pericytes. The recent cancer microarray database revealed upregulation of fibulin-7 (Fbln7), a member of the fibulin family, but provided no information on the tissue localization or biological function. In the present study, we demonstrated that Fbln7 is markedly overexpressed by the GBM tissue among astrocytic tumors, and immunolocalized mainly to endothelial cells and pericytes of the glomeruloid and hypertrophied microvessels. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32306
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http://dx.doi.org/10.1002/ijc.32306DOI Listing
March 2019
1 Read

Cancer incidence and mortality among firefighters.

Authors:
Tomoyuki Kawada

Int J Cancer 2019 Mar 28. Epub 2019 Mar 28.

Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan.

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http://dx.doi.org/10.1002/ijc.32302DOI Listing

Author's Reply to: Cancer incidence and mortality among firefighters.

Int J Cancer 2019 Mar 28. Epub 2019 Mar 28.

Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway.

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http://dx.doi.org/10.1002/ijc.32300DOI Listing

High metabolic rate and stem cell characteristics of esophageal cancer stem-like cells depend on the Hsp27-AKT-HK2 pathway.

Int J Cancer 2019 Mar 28. Epub 2019 Mar 28.

Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Tumor progression with chemoresistance and local recurrence is commonly happened during treatment of esophageal squamous cell carcinoma (ESCC). Cancer stem cells (CSC) may respond for tumor progression. However, there are few reports regarding metabolism of esophageal CSCs with clinical correlation. Read More

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http://dx.doi.org/10.1002/ijc.32301DOI Listing