2,231 results match your criteria International journal of andrology[Journal]


Retraction. Effects of exposure to a mobile phone on testicular function and structure in adult rabbit.

Authors:

Int J Androl 2012 Aug;35(4):629

View Article

Download full-text PDF

Source
August 2012
3 Reads

Novel mutations in calcium/calmodulin-dependent protein kinase IV (CAMK4) gene in infertile men.

Int J Androl 2012 Dec 17;35(6):810-8. Epub 2012 Aug 17.

Centre for Cellular and Molecular Biology, Hyderabad, India.

Calcium/calmodulin-dependent protein kinase IV (CAMK4) is a multifunctional serine/threonine protein kinase, which plays an important role in the spermatogenesis by phosphorylating protamines. It has been shown to be involved in the regulation of human sperm motility. Moreover, the Camk4 knockout mice were infertile because of severely reduced sperm count and morphological abnormalities. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2605.2012.01302.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2605.2012.01302.xDOI Listing
December 2012
5 Reads
2 Citations
3.695 Impact Factor

Variations in testosterone pathway genes and susceptibility to testicular cancer in Norwegian men.

Int J Androl 2012 Dec 12;35(6):819-27. Epub 2012 Aug 12.

Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway.

Imbalance between the oestrogen and androgen levels in utero is hypothesized to influence testicular cancer (TC) risk. Thus, variation in genes involved in the action of sex hormones may contribute to variability of an individual's susceptibility to TC. Mutations in testosterone pathway genes may alter the level of testosterone in vivo and hypothetically the risk of developing TC. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2605.2012.01297.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2605.2012.01297.xDOI Listing
December 2012
3 Reads

Selective resection of dorsal nerves of penis for premature ejaculation.

Int J Androl 2012 Dec 12;35(6):873-9. Epub 2012 Aug 12.

Department of Urology, Peking University People's Hospital, Beijing, China.

Premature ejaculation (PE) is one of the most prevalent male sexual dysfunctions. Selective resection of the dorsal nerve (SRDN) of penis has recently been used for the treatment of PE and has shown some efficacy. To further clarify the efficacy and safety of SRDN on PE, we performed a preliminary, randomized, placebo-controlled clinical observational study. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2605.2012.01296.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2605.2012.01296.xDOI Listing
December 2012
6 Reads

Significant enrichment of Y-bearing chromosome human spermatozoa using a modified centrifugation technique.

Int J Androl 2012 Dec 12;35(6):880-6. Epub 2012 Aug 12.

Genesis Centre for Fertility and Human Pre-implantation Genetics, Limassol, Cyprus. Australia.

The effective separation of X- and Y-bearing chromosome spermatozoa has been a topic of major attraction to a number of scientific disciplines. Approaches have typically been based upon either the kinetic or the physical characteristics of spermatozoa. Much of the information available to date has either suggested conflicting evidence between different approaches or a lack of repeatability, while other robust and reproducible techniques require expensive equipment and are being questioned with relation to their safety in clinical applications. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2605.2012.01295.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2605.2012.01295.xDOI Listing
December 2012
3 Reads

Thyroid hormones and male sexual function.

Int J Androl 2012 Oct 27;35(5):668-79. Epub 2012 Jul 27.

Department of Clinical Physiopathology, Sexual Medicine and Andrology Unit, University of Florence, Florence, Italy.

The role of thyroid hormones in the control of erectile functioning has been only superficially investigated. The aim of the present study was to investigate the association between thyroid and erectile function in two different cohorts of subjects. The first one derives from the European Male Ageing Study (EMAS study), a multicentre survey performed on a sample of 3369 community-dwelling men aged 40-79 years (mean 60 ± 11 years). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2605.2012.01266.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2605.2012.01266.xDOI Listing
October 2012
16 Reads

New era in sperm selection for ICSI.

Int J Androl 2012 Aug 15;35(4):475-84. Epub 2011 Nov 15.

Department of Reproduction and Development, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Spermatozoa contribute to approximately half of the genome of future progeny, and therefore, have a profound impact on embryo development post-fertilization. Sperm selection based on viability and normal morphology does not eliminate the chance for DNA damaged spermatozoa to be inseminated and may account for a considerable percentage of failed embryo development post-ICSI (Intra cytoplasmic sperm injection). Therefore, sperm selection based on functional sperm characteristics to preclude insemination of DNA damaged spermatozoa have paved the way for successful ICSI outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2011.01227.xDOI Listing
August 2012
4 Reads

Haemorrhoids are associated with erectile dysfunction: a population-based study.

Authors:
J J Keller H-C Lin

Int J Androl 2012 Dec 9;35(6):867-72. Epub 2012 Jul 9.

School of Public Health, Taipei Medical University, Taipei, Taiwan.

Haemorrhoids are associated with regional vascular abnormalities and rectal pain, which are hypothesized to increase the risk of erectile dysfunction (ED); however, few studies have investigated the association between ED and haemorrhoids. This case-control study aimed to estimate the association between haemorrhoids and ED by using a population-based data in Taiwan. We identified 6,310 patients with ED as cases and randomly selected 31,550 controls. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2605.2012.01292.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2605.2012.01292.xDOI Listing
December 2012
7 Reads

Differential concentration and time dependent effects of progesterone on kinase activity, hyperactivation and acrosome reaction in human spermatozoa.

Int J Androl 2012 Oct 9;35(5):633-44. Epub 2012 Jul 9.

Molecular and Cellular Biology Laboratory, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Mumbai, India.

Progesterone has been identified to be one of the physiological regulators of sperm hyperactivation and acrosome reaction. However, the high sensitivity of human spermatozoa to progesterone implies that many may undergo premature hyperactivation and acrosome reaction thereby compromising their ability to fertilize. We hypothesized that if a spermatozoon has to preclude the occurrence of these events prematurely, there should be differential dose- and time-dependent effects on motility and acrosome reaction. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2605.2012.01291.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2605.2012.01291.xDOI Listing
October 2012
3 Reads

Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men.

Int J Androl 2012 Dec 19;35(6):783-92. Epub 2012 Jun 19.

Institute of Clinical Laboratory Medicine, Nanjing Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, China.

Testosterone (T) and vitamin D (VD) interact in androgen deficient men, however, this interaction and subsequent semen quality and bone mineral density (BMD) status is not clear in infertile men. Our objective was to investigate T, VD, semen quality, BMD and their relationships in Chinese infertile men. We conducted a cross-sectional study of 559 men aged 20-40 years, including 195 fertile men, 9 infertile men with known risk factors for osteoporosis (WR) and 355 infertile men without known risk factors for osteoporosis (WOR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01287.xDOI Listing
December 2012
16 Reads

Age at puberty and risk of testicular cancer: a meta-analysis.

Int J Androl 2012 Dec 19;35(6):828-34. Epub 2012 Jun 19.

University of Turin, Department of Medical Sciences, Cancer Epidemiology Unit, CeRMS and CPO-Piemonte, Turin, Italy.

Testicular cancer is one of the most rapidly increasing tumour types but its aetiology is still largely unexplained. Cryptorchidism and familial testicular cancer, established risk factors, explain less than 10% of all cases. Among investigated post-natal factors, early puberty was suggested as a potential risk factor but the topic has been poorly investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01286.xDOI Listing
December 2012
2 Reads

The role of male chromosomal polymorphism played in spermatogenesis and the outcome of IVF/ICSI-ET treatment.

Int J Androl 2012 Dec 19;35(6):802-9. Epub 2012 Jun 19.

Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.

Chromosomal polymorphism has been reported to be associated with infertility, but its effect on IVF/ICSI-ET outcome is still controversial. To evaluate whether or not chromosomal polymorphism in men plays a role in spermatogenesis and the outcome of IVF/ICSI-ET, we retrospectively analysed 281 infertile couples. Measures included fertilization rate, implantation rate, pregnancy rate, clinical pregnancy rate, ongoing pregnancy rate, early miscarriage rate and preterm rate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01284.xDOI Listing
December 2012
12 Reads

Imbalance of MMP-2 and MMP-9 expression versus TIMP-1 and TIMP-2 reflects increased invasiveness of human testicular germ cell tumours.

Int J Androl 2012 Dec 19;35(6):835-44. Epub 2012 Jun 19.

Department of Chemistry, Laboratory of Biochemistry, University of Patras, Greece.

The histological classification of testicular germ cell tumours (TGCTs) to seminoma or non-seminomatous germ cell tumours is at present the main criterion for the clinical outcome and selection of the treatment strategy. In view of the need to identify novel prognostic biomarkers for TGCTs, we investigated the expression of the matrix metalloproteinases MMP-2 and MMP-9 in testicular tumour tissues and cell lines of both seminoma and non-seminoma origin. Immunohistochemistry and zymography analysis of tumoural tissues showed significantly higher levels of MMP-2 and MMP-9 compared with normal testis with the active forms detected only in the tumour tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01289.xDOI Listing
December 2012
5 Reads

Androgen depletion augments antibacterial prostate host defences in rats.

Int J Androl 2012 Dec 19;35(6):845-59. Epub 2012 Jun 19.

Centro de Microscopía Electrónica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HRA Córdoba, Argentina.

The defence of the male reproductive tract against microorganisms is critical for fertilization. The prostate gland has been reported to express several molecules of the innate immune system. However, little information is available about how androgens may modulate host defences within the prostate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01288.xDOI Listing
December 2012
4 Reads

Effects of nucleotides adenosine monophosphate and adenosine triphosphate in combination with L-arginine on male rabbit corpus cavernosum tissue.

Int J Androl 2012 Dec 19;35(6):860-6. Epub 2012 Jun 19.

Department of Urology, Hôpital Bichat, Paris, France.

Purines and more specifically adenosine monophosphate (AMP) and adenosine triphosphate (ATP) have a strong relaxant effect on smooth muscle cells of the dog, rabbit and human corpus cavernosum, to approximately the same degree as nitric oxide (NO). However, purines are considered as modulators of erectile function rather than key mediators. This suggests that the use of purines combined with NO donors could be effective to treat some specific erectile disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01290.xDOI Listing
December 2012
15 Reads

Focus on paediatric and adolescent varicocoele: a single institution experience.

Int J Androl 2012 Oct 19;35(5):700-5. Epub 2012 Jun 19.

Department for Mother & Child Care, Pediatric Urology, Università di Palermo, Palermo, Italy.

The aim of this study was to report our long-term diagnostic and surgical outcome during the last 18 years, in paediatric and adolescent management of varicocoele. The present retrospective study enrols 374 patients observed at our institution between 1994 and 2011. Patients were divided into three groups: Group A includes 142 youngsters and adolescents treated with open surgery for left varicocoele, in which a pre-operative CDUS was not performed; Group B includes 65 patients treated with open surgery in which a pre-operative CDUS evaluation was carried out, to assess varicocoele haemodynamic pattern and testicular volume. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01283.xDOI Listing
October 2012
13 Reads

Clinical correlates of sex steroids and gonadotropins in men over the late adulthood: the Framingham Heart Study.

Int J Androl 2012 Dec 29;35(6):775-82. Epub 2012 May 29.

Preventive Medicine & Epidemiology Section, Boston University School of Medicine, Boston, MA, USA.

Low serum concentrations of sex steroids and gonadotropins in men have been associated with increased cardiometabolic risk and mortality, but the clinical correlates of these hormones in men over late adulthood are less clearly understood. We analysed up to five serial measurements of total testosterone (TT), dehydroepiandrosterone sulphate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH) and total estradiol (EST) in older men in the original cohort of the Framingham Heart Study to determine the short- (2-years; 1,165 person-observations in 528 individuals) and long-term (up to 10-years follow-up; 2520 person-observations in 835 individuals with mean baseline age: 71.2 years) clinical correlates of these sex steroids and gonadotropins using multilevel modelling and Generalized Estimating Equations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01285.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434249PMC
December 2012
2 Reads

Evidence for an adaptation in ROS scavenging systems in human testicular peritubular cells from infertility patients.

Int J Androl 2012 Dec 29;35(6):793-801. Epub 2012 May 29.

Anatomy and Cell Biology, Biedersteiner Strasse 29, D-80802 Munich, Germany.

Fibrosis, increased amounts of immune cells and expression of COX-2 in the testes of infertility patients provide circumstantial evidence for a specific testicular milieu, in which reactive oxygen species (ROS) could be increased. If ROS level increase and/or ROS scavengers decrease, the resulting testicular oxidative stress may contribute to human male infertility. Primary peritubular cells of the human testis, from men with normal spermatogenesis (HTPCs) and infertile patients (HTPC-Fs), previously allowed us to identify an end product of COX-2 action, a prostaglandin derivative (15dPGJ2), which acts via ROS to alter the phenotype of peritubular cells, at least in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01281.xDOI Listing
December 2012
13 Reads

Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters.

Int J Androl 2012 Jun;35(3):424-36

Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.

Today, topical application of sunscreens, containing ultraviolet-filters (UV-filters), is preferred protection against adverse effects of ultraviolet radiation. Evidently, use of sunscreens is effective in prevention of sunburns in various models. However, evidence for their protective effects against melanoma skin cancer is less conclusive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01280.xDOI Listing
June 2012
29 Reads

Modelling defined mixtures of environmental oestrogens found in domestic animal and sewage treatment effluents using an in vitro oestrogen-mediated transcriptional activation assay (T47D-KBluc).

Int J Androl 2012 Jun;35(3):397-406

Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, USA.

There is growing concern of exposure of fish, wildlife and humans to water sources contaminated with oestrogens and the potential impact on reproductive health. Environmental oestrogens can come from various sources including concentrated animal feedlot operations (CAFO), municipal waste, agricultural and industrial effluents. US EPA's drinking water contaminant candidate list 3 (CCL3) includes several oestrogenic compounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01278.xDOI Listing
June 2012
28 Reads

Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis.

Int J Androl 2012 Jun;35(3):377-84

Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

More than half the pregnant women in the Western world report taking mild analgesics. These pharmaceutical compounds have been associated with congenital cryptorchidism in humans, the best-known risk factor for low semen quality and testicular germ cell cancer. Furthermore, some of these mild analgesics exert potent anti-androgenic effects in the male rat and several endocrine-disrupting compounds, known to alter masculinization, have also been shown to be potent inhibitors of prostaglandin (PG) synthesis similar to mild analgesics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01282.xDOI Listing
June 2012
16 Reads

Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia.

Int J Androl 2012 Jun;35(3):227-35

Department of Growth and Reproduction, Rigshospitalet, Faculty of Healthy Sciences, University of Copenhagen, Copenhagen, Denmark.

Pubertal gynaecomastia is a clinical sign of an oestrogen-androgen imbalance, which occurs in 40-60% of adolescent Caucasian boys. In most cases no underlying endocrinopathy can be identified. A recent study reports higher plasma phthalate levels in Turkish boys with pubertal gynaecomastia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01279.xDOI Listing
June 2012
10 Reads

High prevalence of androgen deficiency and abnormal lipid profile in infertile men with non-obstructive azoospermia.

Int J Androl 2012 Oct 20;35(5):688-94. Epub 2012 Apr 20.

Reproductive Medicine Centre, Skåne University Hospital Malmö, Lund University, Malmö, Sweden.

In men with non-obstructive azoospermia (NOA), the risk of hypogonadism is often overlooked. Testicular sperm extraction (TESE) may increase this risk. The objective of this study was to elucidate the prevalence of hypogonadism in NOA-patients, the impact of TESE on hormone balance and the association between testosterone deficiency and dyslipidaemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01277.xDOI Listing
October 2012
2 Reads

Sperm chromatin integrity may predict future fertility for unexplained recurrent spontaneous abortion patients.

Int J Androl 2012 Oct 20;35(5):752-7. Epub 2012 Apr 20.

Shandong Provincial Key Laboratory for Improving Birth Outcome Technique, Shandong Provincial Research Institute for Family Planning, Jinan 250002, China.

The pathogenesis of recurrent spontaneous abortion (RSA) is multi-factorial, complex and poorly understood. In the present study, semen parameters, including sperm chromatin integrity, sperm concentration, sperm motility and sperm morphology, were compared between 111 men whose partners had a history of unexplained RSA (RSA group) and 30 healthy fertile men (control group). The RSA group was further separated into three subgroups, depending on their reproductive outcome during the 12 months after they were enrolled in the study: the pregnancy subgroup consisted of 43 men whose partners achieved a successful pregnancy up to at least the 24th week of gestation; the abortion subgroup included 31 men whose partners experienced further abortions; and the infertile subgroup had 37 men whose partners did not have any positive pregnancy test after regular, unprotected intercourse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01276.xDOI Listing
October 2012
28 Reads

The relationship between anogenital distance and azoospermia in adult men.

Int J Androl 2012 Oct 23;35(5):726-30. Epub 2012 Apr 23.

Department of Urology, Stanford University School of Medicine, Palo Alto, CA 94305-5118, USA.

Anogenital distance (AGD) is a marker for endocrine disruption in animal studies in which decreased male AGD has been associated with testicular dysfunction. The objective of the study was to investigate whether anogenital distance could distinguish men with obstructive azoospermia (OA) from those with nonobstructive azoospermia (NOA). To accomplish this, azoospermic men were recruited and evaluated at a men's reproductive health clinic in Houston, TX. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01275.xDOI Listing
October 2012
9 Reads

Subclinical endothelial dysfunction and low-grade inflammation play roles in the development of erectile dysfunction in young men with low risk of coronary heart disease.

Int J Androl 2012 Oct 23;35(5):653-9. Epub 2012 Apr 23.

Division of Ultrasound, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

The purpose of this study is to investigate the possible underlying pathogenesis of erectile dysfunction(ED) in young men with low risk of coronary heart disease and no well-known aetiology. To conduct this study, 122 patients with ED under the age of 40 were enrolled, along with 33 age-matched normal control subjects. The patients with ED had significantly higher levels of systolic blood pressure (SBP), total cholesterol and triglyceride, high sensitivity C-reactive protein (hs-CRP), greater carotid intima-media thickness (CIMT) and Framingham risk score (FRS) than the control group, though all of these values were within the respective normal range. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01273.xDOI Listing
October 2012
16 Reads

Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine in patients with arteriogenic and non-arteriogenic erectile dysfunction.

Int J Androl 2012 Oct 20;35(5):660-7. Epub 2012 Apr 20.

Unita' di Chimica e Biochimica Analitica, Dipartimento di Medicina, Chirurgia e Odontoiatria, Università degli Studi di Milano, Italy.

The plasma concentration of asymmetrical dimethylarginine (ADMA), an inhibitor of nitric oxide synthase, has been linked to endothelial dysfunction. We investigated the relation between ADMA, symmetric dimethylarginine (SDMA) and L-arginine concentrations and erectile dysfunction. We compared plasma levels of ADMA, SDMA and L-arginine in 61 men in good health with erectile dysfunction of arteriogenic and non-arteriogenic origin. Read More

View Article

Download full-text PDF

Source
http://www.andrologiaonline.it/sci_news_pdf/204/204.pdf
Web Search
http://doi.wiley.com/10.1111/j.1365-2605.2012.01272.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2605.2012.01272.xDOI Listing
October 2012
7 Reads

Vasectomy reversal using a microsurgical three-layer technique: one surgeon's experience over 18 years with 1300 patients.

Authors:
J U Schwarzer

Int J Androl 2012 Oct 20;35(5):706-13. Epub 2012 Apr 20.

Andrologie-Centrum-Muenchen, Munich, Germany.

The technique and the results of microsurgical vasectomy reversal in a single-centre study over 18 years are presented. Both vasovasostomy (VV) and epididymovasostomy (EV) were carried out in a three-layer technique. With strict adherence to the strategy, end-to-end VV was only performed if spermatozoa had been demonstrated at the epididymal stump of the vas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01270.xDOI Listing
October 2012
2 Reads

Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures.

Int J Androl 2012 Jun 23;35(3):294-302. Epub 2012 Apr 23.

Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.

During the past four decades, there has been an increase in the incidence rate of male reproductive disorders in some, but not all, Western countries. The observed increase in the prevalence of male reproductive disorders is suspected to be ascribable to environmental factors as the increase has been too rapid to be explained by genetics alone. To study the association between complex chemical exposures of humans and congenital cryptorchidism, the most common malformation of the male genitalia, we measured 121 environmental chemicals with suspected or known endocrine disrupting properties in 130 breast milk samples from Danish and Finnish mothers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01268.xDOI Listing
June 2012
11 Reads

Glial cell line-derived neurotrophic factor promotes invasive behaviour in testicular seminoma cells.

Int J Androl 2012 Oct 23;35(5):758-68. Epub 2012 Apr 23.

Department of Anatomy, Histology, Forensic Medicine and Orthopedic, Section of Histology, Fondazione Pasteur Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.

The glial cell line-derived neurotrophic factor (GDNF) has multiple functions that promote cell survival, proliferation and migration in different cell types. The experimental over-expression of GDNF in mouse testis leads to infertility and promotes seminomatous germ cell tumours in older animals, which suggests that deregulation of the GDNF pathway may be implicated in germ cell carcinogenesis. GDNF activates downstream pathways upon binding to its specific co-receptor GDNF family receptor-a 1 (GFRA1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01267.xDOI Listing
October 2012
31 Reads

Are apolipoprotein E alleles correlated with semen quality?

Int J Androl 2012 Oct 10;35(5):714-9. Epub 2012 Apr 10.

Laboratory of Seminology-Sperm Bank, Department of Experimental Medicine, University of Rome La Sapienza, Rome, Italy.

Apolipoproteins have a unique role in lipoprotein metabolism regulation, aiding lipid transport and acting as a cofactor of the enzymes involved in metabolism. There are three co-dominant alleles, APOE*2, APOE*3 and APOE*4, which encode three protein isoforms, apoE2, apoE3 and apoE4. APOE*3 is the most frequent in all populations thus far investigated, ranging from 50 to 90%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01263.xDOI Listing
October 2012
20 Reads

Reduced artery diameters in Klinefelter syndrome.

Int J Androl 2012 Oct 10;35(5):720-5. Epub 2012 Apr 10.

Department of Molecular Medicine, Section of Clinical Pathology and Center for Human Reproduction Pathology, University of Padova, Padova, Italy.

Various epidemiological studies in relatively large cohorts of patients with Klinefelter syndrome (KS) described the increased morbidity and mortality in these subjects. Our aim was to study the structure and function of arteries in different districts to investigate in these subjects possible alterations. A total of 92 patients having non-mosaic KS, diagnosed in Centre for Human Reproduction Pathology at the University of Padova, and 50 age-matched healthy male controls were studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01269.xDOI Listing
October 2012
14 Reads

Increasing trends in childlessness in recent birth cohorts - a registry-based study of the total Danish male population born from 1945 to 1980.

Int J Androl 2012 Jun 10;35(3):449-55. Epub 2012 Apr 10.

University Department of Growth & Reproduction, Rigshospitalet, Copenhagen, Denmark.

The fertility rate has recently declined in many parts of the World, including Europe. To a large extent, this change can be explained by the socio-economic development. However, increasing fertility problems and widespread occurrence of poor semen quality could in part explain the few births. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01265.xDOI Listing
June 2012
7 Reads

Investigation of the expression and functional significance of the novel mouse sperm protein, a disintegrin and metalloprotease with thrombospondin type 1 motifs number 10 (ADAMTS10).

Int J Androl 2012 Aug 28;35(4):572-89. Epub 2012 Mar 28.

Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, Australia.

Fertilization represents the culmination of a series of complex interactions between male and female gametes. Despite advances in our understanding, the precise molecular mechanisms underlying these fundamental interactions remain largely uncharacterized. There is however growing recognition that this process requires the concerted action of multiple sperm receptors that possess affinity for complementary zona pellucida ligands and those that reside on the surface of the oolemma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2011.01235.xDOI Listing
August 2012
2 Reads

Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system.

Int J Androl 2012 Oct 21;35(5):731-40. Epub 2012 Mar 21.

Centre for Public Health, Institute of Clinical Science, Queens University of Belfast, Belfast, UK.

Recent societal acceptance of cannabinoids as recreational and therapeutic drugs has posed a potential hazard to male reproductive health. Mammals have a highly sophisticated endogenous cannabinoid (ECS) system that regulates male (and female) reproduction and exo-cannabinoids may influence it adversely. Therefore it is imperative to determine their effects on male reproduction so that men can make informed choices as to their use. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2605.2012.01259.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2605.2012.01259.xDOI Listing
October 2012
9 Reads

High urinary phthalate concentration associated with delayed pubarche in girls.

Int J Androl 2012 Jun 19;35(3):216-26. Epub 2012 Mar 19.

Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Phthalates are a group of chemicals present in numerous consumer products. They have anti-androgenic properties in experimental studies and are suspected to be involved in human male reproductive health problems. A few studies have shown associations between phthalate exposure and changes in pubertal timing among girls, although controversies exist. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01260.xDOI Listing
June 2012
9 Reads

Perinatal ethinyl oestradiol alters mammary gland development in male and female Wistar rats.

Int J Androl 2012 Jun 19;35(3):385-96. Epub 2012 Mar 19.

Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Søborg, Denmark.

Increased attention is being paid to human mammary gland development because of concerns for environmental influences on puberty onset and breast cancer development. Studies in rodents have showed a variety of changes in the mammary glands after perinatal exposure to endocrine disrupting chemicals, indicating progressed development of mammary glands when exposed to oestrogens early in life. However, laboratories use different parameters to evaluate the development of mammary glands, making studies difficult to compare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01258.xDOI Listing
June 2012
2 Reads

Detection of endocrine disruptors - from simple assays to whole genome scanning.

Int J Androl 2012 Jun 19;35(3):407-14. Epub 2012 Mar 19.

School of Biosciences, University of Birmingham, Birmingham, UK.

Endocrine disruptors frequently bear little structural relationship to the hormone whose actions they disrupt. Consequently, the threat of an uninvestigated chemical cannot easily be assessed. Here three different approaches to assessment are discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01254.xDOI Listing
June 2012
2 Reads

Neurotrophic effect of bone marrow mesenchymal stem cells for erectile dysfunction in diabetic rats.

Int J Androl 2012 Aug 19;35(4):601-7. Epub 2012 Mar 19.

Department of Urology, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China.

It has been demonstrated that intracavernous injection of bone marrow-derived mesenchymal stem cells (BM-MSCs) had beneficial effects on improving erectile function in type-1 diabetic rats. This study was designed to investigate the neurotrophic effect of BM-MSCs for type-1 diabetic rats. Streptozocin-induced type-1 diabetic rats were randomly divided into three groups: diabetic group, BM-MSCs-treated group and BM-MSCs-conditioned medium-treated group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01250.xDOI Listing
August 2012
13 Reads

Effects of inducible nitric oxide synthase (iNOS) deficiency in mice on Sertoli cell proliferation and perinatal testis development.

Int J Androl 2012 Oct 15;35(5):741-51. Epub 2012 Mar 15.

Department of Morphology, Laboratory of Cellular Biology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Nitric oxide (NO) plays crucial roles in several physiological and pathological conditions. The iNOS isoform produces high levels of NO independent of intracellular calcium and, in the testis, which is expressed in Sertoli (SC), Leydig (LC) and germ cells. The testicular roles of NO are unclear, but it can inhibit LC testosterone production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01264.xDOI Listing
October 2012
3 Reads

Differences in the clinical characteristics between young and elderly men with varicocoele.

Authors:
S-S Chen

Int J Androl 2012 Oct 15;35(5):695-9. Epub 2012 Mar 15.

Division of Urology, Taipei City Hospital Renai branch, Department of Urology, National Yang-Ming University School of Medicine.

Information concerning the clinical characteristics in elderly men with varicocoele is relatively limited. This study was assessed to evaluate the differences in clinical characteristics between young and elderly patients with varicocoele by retrospective chart review. Between June 2003 and February 2011, 169 young (18-30 years) men and 156 elderly (45-55 years) men with varicocoele, and 30 age-matched men without varicocoele were recruited for this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01257.xDOI Listing
October 2012
2 Reads

Relationship between conventional sperm parameters and motile sperm organelle morphology examination (MSOME).

Int J Androl 2012 Aug 15;35(4):491-8. Epub 2012 Mar 15.

EA 4308 Spermatogenesis and male gamete quality, Reproductive Biology Laboratory-CECOS, Rouen University Hospital, Rouen Cedex, France.

With the motile sperm organelle morphology examination (MSOME), spermatozoa morphology may be assessed directly on motile spermatozoa at high magnification (up to 6600×). This procedure describes more precisely spermatozoa abnormalities, especially head vacuoles. However, no consensus has been established concerning normal or abnormal MSOME criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01249.xDOI Listing
August 2012
6 Reads

High levels of the extracellular matrix proteoglycan decorin are associated with inhibition of testicular function.

Int J Androl 2012 Aug 15;35(4):550-61. Epub 2011 Nov 15.

Anatomy and Cell Biology, Ludwig-Maximilians-University Munich, Munich, Germany.

Decorin (DCN), a component of the extracellular matrix of the peritubular wall and the interstitial areas of the human testis, can interact with growth factor (GF) signalling, thereby blocking downstream actions of GFs. In the present study the expression and regulation of DCN using both human testes and two experimental animal models, namely the rhesus monkey and mouse, were examined. DCN protein was present in peritubular and interstitial areas of adult human and monkey testes, while it was almost undetectable in adult wild type mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2011.01225.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376671PMC
August 2012
11 Reads

Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality.

Int J Androl 2012 Aug 9;35(4):499-510. Epub 2012 Mar 9.

University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.

Vitamin D (VD) is important for male reproduction in mammals and the VD receptor (VDR) and VD-metabolizing enzymes are expressed in human spermatozoa. The VD-inactivating enzyme CYP24A1 titrates the cellular responsiveness to VD, is transcriptionally regulated by VD, and has a distinct expression at the sperm annulus. Here, we investigated if CYP24A1 expression serves as a marker for VD metabolism in spermatozoa, and whether CYP24A1 expression was associated with semen quality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01256.xDOI Listing
August 2012
8 Reads

Early breast development in girls after prenatal exposure to non-persistent pesticides.

Int J Androl 2012 Jun 9;35(3):273-82. Epub 2012 Mar 9.

University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.

Contemporary American and European girls experience breast development at earlier ages compared with 15-20 years ago. Alterations in BMI alone cannot account for these changes. Several currently used pesticides possess endocrine disrupting properties and may interfere with reproductive development, but human data are sparse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2011.01244.xDOI Listing
June 2012
4 Reads

No effects of n-3 fatty acid supplementation on serum total testosterone levels in older men: the Alpha Omega Trial.

Int J Androl 2012 Oct 6;35(5):680-7. Epub 2012 Mar 6.

Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.

The intake of the n-3 fatty acids alpha-linolenic acid (ALA), acid (EPA) and docosahexaenoic acid (DHA) has been related to testosterone levels in epidemiological analyses. The aim of this study was to assess whether the n-3 fatty acids affects testosterone levels in post-myocardial infarction (MI) patients, who are at risk of testosterone deficiency. In a double-blind, placebo-controlled trial of low-dose supplementation of n-3 fatty acids, we included 1850 male post-MI patients aged 60-80 years who participated in the Alpha Omega Trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01255.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387289PMC
October 2012
4 Reads

Serum from patients with erectile dysfunction inhibits circulating angiogenic cells from healthy men: relationship with cardiovascular risk, endothelial damage and circulating angiogenic modulators.

Int J Androl 2012 Oct 6;35(5):645-52. Epub 2012 Mar 6.

Department of Internal Medicine, Andrology Unit, University of L'Aquila, Italy.

Erectile dysfunction (ED) is an early manifestation of arteriosclerosis associated with endothelial damage/dysfunction and to a blunted ability of cultured mononuclear circulating cells (MNCs) to differentiate circulating angiogenic cells (CACs), putatively involved in endothelial damage repair. Here we explored effects of human serum (HS) from patients with ED and cardiovascular risk factors (VRFs) but no clinical atherosclerosis, on cultured MNCs of healthy men to differentiate CACs and to form colonies. Effect of HS on number of CACS and of colony forming units (CFUs) was correlated with circulating markers of endothelial damage and with angiogenic modulators. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2605.2012.01253.xDOI Listing
October 2012
3 Reads