496,350 results match your criteria International journal for vitamin and nutrition research. Internationale Zeitschrift fuer Vitamin- und Ernaehrungsforschung. Journal international de vitaminologie et de nutrition[Journal]


Nationwide Survey of Intratympanic Steroids for the Management of Sudden Sensorineural Hearing Loss.

Isr Med Assoc J 2019 Feb;21(2):105-109

Department of Otolaryngology - Head and Neck Surgery, Western Galilee Medical Center, Nahariya, Israel.

Background: The currently accepted treatment for idiopathic sudden sensorineural hearing loss (ISSHL) is systemic steroids as first-line and intratympanic steroids as salvage therapy. Intratympanic (IT) treatment is applied worldwide in many different ways with no universally accepted protocol.

Objectives: To present the current disparity in ISSHL management and to discuss the necessity for establishing a common national protocol. Read More

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February 2019

Circle of Willis variations in migraine patients with ischemic stroke.

Brain Behav 2019 Feb 16:e01223. Epub 2019 Feb 16.

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke with and without migraine.

Materials And Methods: Participants were recruited from the prospective Dutch acute Stroke Study. Read More

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http://dx.doi.org/10.1002/brb3.1223DOI Listing
February 2019

Novel use of tranexamic acid to reduce the need for Nasal Packing in Epistaxis (NoPac) randomised controlled trial: research protocol.

BMJ Open 2019 Feb 15;9(2):e026882. Epub 2019 Feb 15.

Research Design Service South West, Bristol, UK.

Introduction: Patients presenting to emergency departments (EDs) with epistaxis uncontrolled by subsequent simple first aid measures or application of topical vasoconstrictors will typically undergo anterior nasal packing. Packing is effective, but can be extremely painful and unpleasant and patients usually need hospital admission. Tranexamic acid (TXA) is a cheap, safe, readily available antifibrinolytic agent known to be beneficial in a variety of clinical settings where uncontrolled bleeding may be a problem. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026882DOI Listing
February 2019

VaccHemInf project: protocol for a prospective cohort study of efficacy, safety and characterisation of immune functional response to vaccinations in haematopoietic stem cell transplant recipients.

BMJ Open 2019 Feb 15;9(2):e026093. Epub 2019 Feb 15.

Département des Maladies Infectieuses et Tropicales, Hospices Civils de Lyon, Lyon, France.

Introduction: Immune reconstitution after haematopoietic stem cell transplantation (HSCT) is a complex and dynamic process, varying from a state of nearly complete immunosuppression to an expected full immune recovery. Specific vaccination guidelines recommend reimmunisation after HSCT but data regarding vaccine efficacy in this unique population are scarce. New immune functional assays could enable prediction of vaccine response in the setting of HSCT. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026093DOI Listing
February 2019

Impact of repeated hospital accreditation surveys on quality and reliability, an 8-year interrupted time series analysis.

BMJ Open 2019 Feb 15;9(2):e024514. Epub 2019 Feb 15.

Statistical Society-Central Luzon State University, Luzon, The Philippines.

Objective: To evaluate whether hospital re-accreditation improves quality, patient safety and reliability over three accreditation cycles by testing the accreditation life cycle model on quality measures.

Design: The validity of the life cycle model was tested by calibrating interrupted time series (ITS) regression equations for 27 quality measures. The change in the variation of quality over the three accreditation cycles was evaluated using the Levene's test. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024514DOI Listing
February 2019

Performance of biological mesh materials in abdominal wall reconstruction: study protocol for a randomised controlled trial.

BMJ Open 2019 Feb 15;9(2):e024091. Epub 2019 Feb 15.

Department of Surgery, University of Calgary and the Foothills Medical Centre, Calgary, Alberta, Canada.

Introduction: Abdominal wall hernias are a common source of morbidity and mortality. The use of biological mesh has become an important adjunct in successful abdominal wall reconstruction. There are a variety of biological mesh products available; however, there is limited evidence supporting the use of one type over another. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024091DOI Listing
February 2019

PROFIT, a PROspective, randomised placebo controlled feasibility trial of Faecal mIcrobiota Transplantation in cirrhosis: study protocol for a single-blinded trial.

BMJ Open 2019 Feb 15;9(2):e023518. Epub 2019 Feb 15.

James Black Centre, School of Immunology & Microbial Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.

Introduction: Patients with advanced cirrhosis have enteric bacterial dysbiosis and translocation of bacteria and their products across the gut epithelial barrier. This culminates in systemic inflammation and endotoxaemia, inducing innate immune dysfunction which predisposes to infection, and development of complications such as bleeding, sepsis and hepatic encephalopathy. This feasibility study aims to assess the safety of administering faecal microbiota transplantion to patients with cirrhosis and explore the effect of the intervention on their prognosis by achieving restoration of a healthy gut microbiome. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023518DOI Listing
February 2019

Localized high grade endometrial stromal sarcoma and localized undifferentiated uterine sarcoma: a retrospective series of the French Sarcoma Group.

Int J Gynecol Cancer 2019 Feb 16. Epub 2019 Feb 16.

Department of Medical Oncology, CHU Timone, AP-HM, Marseille, France.

Objective: High grade endometrial stromal sarcoma and undifferentiated uterine sarcomas are associated with a very poor prognosis. Although large surgical resection is the standard of care, the optimal adjuvant strategy remains unclear.

Methods: A retrospective analysis of patients with localized high grade endometrial stromal sarcoma and undifferentiated uterine sarcomas (stages I-III) treated in 10 French Sarcoma Group centers was conducted. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000064DOI Listing
February 2019

Twelve-month analgesia and rescue, by cooled radiofrequency ablation treatment of osteoarthritic knee pain: results from a prospective, multicenter, randomized, cross-over trial.

Reg Anesth Pain Med 2019 Feb 16. Epub 2019 Feb 16.

Center for Clinical Research, Winston Salem, North Carolina, USA

Background And Objectives: As a follow-up to the 6-month report,12 this study investigated the analgesic effect of cooled radiofrequency ablation (CRFA) in patients with knee osteoarthritis (OA) 12 months postintervention and its ability to provide pain relief in patients who experienced unsatisfactory effects of intra-articular steroid injection (IAS).

Methods: Seventy-eight per cent (52/67) of patients originally treated with CRFA were evaluated at 12 months, while at 6 months post-IAS, 82% (58/71) of those patients crossed over to CRFA and assessed 6 months later.

Results: At 12 months, 65% of the original CRFA group had pain reduction ≥50%, and the mean overall drop was 4. Read More

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http://dx.doi.org/10.1136/rapm-2018-100051DOI Listing
February 2019

Short Communication: Discovery and molecular docking simulation of 7-hydroxy-6-methoxy-2H-chromen-2-one as a LOX Inhibitor.

Pak J Pharm Sci 2019 Jan;32(1):217-220

International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.

Millettia ovalifolia is traditionally used in variety of diseases including inflammation. In our investigation in to the phytochemical constituents of Millettia ovalifolia an effort was made to find out bioactive constituent from medicinal Plant M. ovalifolia to scientifically validate its use in inflammatory disorders. Read More

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January 2019

Oxidative stress associated with altered activity of glutathione peroxidase and superoxide dismutase enzymes with IDA during pregnancy.

Pak J Pharm Sci 2019 Jan;32(1):75-79

Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.

Iron deficiency anemia (IDA) during pregnancy, although associated with disturbances of hematological parameters, is now also considered as a source of oxidative stress (OS). Present study aims to detect any alteration in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) enzymes activity in pregnant women with IDA. Levels of GSH-Px and SOD were measured in 156 anemic, pregnant women and compared with similar levels in 20 non anemic, pregnant women. Read More

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January 2019

Thiosemicarbazone and thiazolylhydrazones of 1-indanone: As a new class of nonacidic anti-inflammatory and antiplatelet aggregation agents.

Pak J Pharm Sci 2019 Jan;32(1):15-19

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.

This research based on the anti-inflammatory and antiplatelet aggregation properties of some new thiazolyl hydrazone derivatives of 1-indanone. In this regard a thiosemicabazone and twelve thiazolyl derivatives of 1-indanone have been synthesized. Out of these synthetic compounds seven derivatives 1-3, 6, 11-13 exhibited varying degree of anti-inflammatory action with IC esteems going from 5. Read More

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January 2019

Histopathology mapping of biochemical changes in diffuse axonal injury by FTIR micro-spectroscopy.

Leg Med (Tokyo) 2019 Feb 2;37:76-82. Epub 2019 Feb 2.

Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, Hubei, China. Electronic address:

The diagnosis of diffuse axonal injury (DAI) is an important task in forensic pathology and clinical medicine. This study aimed to explore the use of Fourier transform infrared spectroscopy (FTIR) to detect DAI. The DAI area of the rat model was detected point by point by the FTIR-mapping system. Read More

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http://dx.doi.org/10.1016/j.legalmed.2019.02.001DOI Listing
February 2019

Increasing nursing students' knowledge of evidence-based hand-hygiene: A quasi-experimental study.

Nurse Educ Pract 2019 Jan 2;35:104-110. Epub 2019 Jan 2.

Department of Children and Women, Oulu University Hospital, Finland. Electronic address:

Aim of study was to evaluate the effects of a multi-component intervention on nursing students' knowledge of evidence-based hand-hygiene. A quasi-experimental design was used. Nursing students (N = 146) from two universities of applied sciences (experimental group n = 107, control group n = 39) completed an instrument based on international clinical guidelines related to hand hygiene that consisted of 17 Likert-scale items. Read More

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http://dx.doi.org/10.1016/j.nepr.2018.12.009DOI Listing
January 2019

Potentially toxic elements (PTEs) and polycyclic aromatic hydrocarbons (PAHs) in fish and prawn in the Persian Gulf, Iran.

Ecotoxicol Environ Saf 2019 Feb 14;173:251-265. Epub 2019 Feb 14.

Khorramshahr Environmental Protection Office, Khorramshahr 6491846783, Iran.

This study aimed to speciate and quantify potentially toxic elements (PTEs) and polycyclic aromatic hydrocarbons (PAHs), in addition to estimate potential human health risk of PTEs (As, Cd, Co, Cr, Cu, Hg, Mn, Ni, Pb, Se, V, and Zn) through the consumption of three edible fish species (Leuciscus vorax, Liza abu, and Coptodon zillii) and two prawn species (Metapenaeus affinis and Penaeus semisulcatus) collected from Arvand River and Musa Estuary in the Persian Gulf. The concentration of As in prawn species exceeded permissible limit set by international organizations. PAHs were dominated by low molecular weight species such as naphthalene, phenanthrene, and, fluorene but generally exhibited low mean concentrations in fish and prawn samples. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.005DOI Listing
February 2019

Reduced response to gabapentin enacarbil in restless legs syndrome following long-term dopaminergic treatment.

Sleep Med 2018 Dec 26;55:74-80. Epub 2018 Dec 26.

European Sleep Institute, Santiago, Chile. Electronic address:

Objectives: To determine whether long-term treatment with dopaminergic agents (DAs) might dampen the response to a non-dopaminergic agent, such as gabapentin enacarbil.

Methods: We performed a two-week randomized, double-blind, crossover, and placebo-controlled study in a single, referral center in dopamine treatment-naive patients and non-augmented patients continuously treated with dopaminergics for the last five consecutive years. Following washout from any previous CNS-active drugs, patients were randomized into one of two groups for two consecutive two-week treatment periods with gabapentin enacarbil (GBPen) and placebo. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.11.025DOI Listing
December 2018

Remediation of Cd- and Pb- contaminated clay soils through combined freeze-thaw and soil washing.

J Hazard Mater 2019 Feb 11;369:87-95. Epub 2019 Feb 11.

Department of Civil and Environmental Engineering, Setsunan University, Osaka 5728508, Japan.

To improve the washing efficiency for low-permeability clay, the method of freeze-thaw synergistic chemical washing was put forward to study the cadmium (Cd)-and lead (Pb)- real-site contaminated soils as the research object and ethylene diaminete traacetic acid (EDTA) was selected as the eluent to conduct a soil column washing test of heavy metal-contaminated clay soil. Results show that repeated freeze-thaw of soil can destroy the original structure of soil particles, help the eluent fully interact with pollutants, and thus improve washing efficiency. Cd was showed the best removal effect after supplying 0. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.02.038DOI Listing
February 2019

Clinical course of neuromyelitis optica spectrum disorder in a moroccan cohort.

Mult Scler Relat Disord 2019 Feb 10;30:141-148. Epub 2019 Feb 10.

Department of Neurology, Ibn Rochd University Hospital and Hassan II University, Faculty of Medicine and Pharmacy, Address: 1, quartier des hôpitaux, 20100 Casablanca, Morocco.

Background: Neuromyelitis optica spectrum disorder (NMOSD) was suggested to be more frequent and have specific features among populations from Africa or North Africa. However, we could not find any large study about NMOSD in an African population in the medical literature.

Objectives: To describe the characteristics of NMOSD in a Moroccan monocenter population. Read More

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http://dx.doi.org/10.1016/j.msard.2019.02.012DOI Listing
February 2019

Initial results of a randomized phase III trial of high dose image guided radiation with or without androgen deprivation therapy for intermediate-risk prostate cancer.

Cancer Treat Res Commun 2019 Feb 10;19:100119. Epub 2019 Feb 10.

Florida Physician Specialists, Jacksonville, FL, USA.

Background: Prior randomized studies have shown a survival benefit using combined androgen deprivation therapy (ADT) and radiation therapy for intermediate-risk prostate cancer. However, these studies either used low doses of radiation (66.6 Gy to isocenter) or imaged guidance was not available. Read More

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http://dx.doi.org/10.1016/j.ctarc.2019.100119DOI Listing
February 2019

ACCELERATE and European Medicine Agency Paediatric Strategy Forum for medicinal product development for mature B-cell malignancies in children.

Eur J Cancer 2019 Feb 14;110:74-85. Epub 2019 Feb 14.

Department of Clinical Research, Gustave Roussy, Paris-Sud University, Paris, France.

Paediatric Strategy Forums have been created by the multistakeholder organisation, ACCELERATE, and the European Medicines Agency to facilitate dialogue between all relevant stakeholders and suggest strategies in critical areas of paediatric oncology drug development. As there are many medicines being developed for B-cell malignancies in adults but comparatively few in children with these malignancies, a Paediatric Strategy Forum was held to discuss the best approach to develop these products for children. It was concluded that as current frontline therapy is highly successful, despite associated acute toxicity, de-escalation of this or substitution of presently used drugs with new medicines can only be undertaken when there is an effective salvage regimen, which is currently not available. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.01.013DOI Listing
February 2019

Highly synergistic effects on ammonium removal by the co-system of Pseudomonas stutzeri XL-2 and modified walnut shell biochar.

Bioresour Technol 2019 Feb 8;280:239-246. Epub 2019 Feb 8.

Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, Chongqing University, Chongqing 400045, PR China.

Pseudomonas stutzeri strain XL-2 presented efficient ammonium removal due to heterotrophic nitrification-aerobic denitrification. The modified walnut shell biochar also showed ammonium adsorption due to chemical interaction. The complex of modified biochar and strain XL-2 exhibited excellent synergistic effects on ammonium removal, especially in unfavorable environment. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.02.037DOI Listing
February 2019

Biodiesel production through algal cultivation in urban wastewater using algal floway.

Bioresour Technol 2019 Feb 6;280:222-228. Epub 2019 Feb 6.

Diatom Research Laboratory, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh 201 313, India. Electronic address:

The aim of this work was to study algal floway (AFW) to treat urban wastewater and to evaluate biomass productivity, lipid contents and biodiesel production. The results indicated the seasonal average algae productivity of 34.83 g dry weight m d with a nutrient removal rate of 2. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.02.031DOI Listing
February 2019

Nitrate reductase activity in leaves as a plant physiological indicator of in vivo biological nitrification inhibition by Brachiaria humidicola.

Plant Physiol Biochem 2019 Feb 8;137:113-120. Epub 2019 Feb 8.

Institute of Agricultural Sciences in the Tropics (Hans-Ruthenberg-Institute), University of Hohenheim, 70593, Stuttgart, Germany. Electronic address:

The tropical forage grass Brachiaria humidicola (Bh) controls soil microbial nitrification via biological nitrification inhibition (BNI). The aim of our study was to verify if nitrate reductase activity (NRA) in Bh roots or leaves reflects in vivo performance of BNI in soils. NRA was measured in roots and leaves of contrasting accessions and apomictic hybrids of Bh grown under controlled greenhouse and natural field conditions. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.02.002DOI Listing
February 2019

Pediatric tracheostomy first tube change: When is it safe?

Int J Pediatr Otorhinolaryngol 2019 Feb 8;120:78-81. Epub 2019 Feb 8.

Department of Pediatric Otorhinolaryngology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.

Objectives: The first tracheostomy tube change is typically performed on days 5-7 post-operatively, however recent international consensus guidelines suggested that, with maturation sutures, days 3-5 is appropriate. We evaluate whether a first tube change on day 2 post-operatively is safe and effective.

Methods: We carried out a retrospective review of all patients undergoing tracheostomy between 2009 and 2018. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.017DOI Listing
February 2019

Clustered risk: An ecological understanding of sexual activity among adolescent boys and girls in two urban slums in Monrovia, Liberia.

Soc Sci Med 2019 Feb 8;224:106-115. Epub 2019 Feb 8.

Department of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, Division of Adolescent and Young Adult Medicine, Boston Children's Hospital, 677 Huntington Avenue, Boston, MA, 02115, USA. Electronic address:

Many young people experience sexual debut before they are able to manage risk in order to avoid adverse consequences. Gender norms, social position, and power can undermine an adolescent's ability to exercise agency in their first sexual encounters and negotiate safer sexual behavior. This study examines the intersection of psychosocial and interpersonal factors with the social and physical environment to form an ecological understanding of how the determinants that shape sexual activity differ between boys and girls in two urban slums in Monrovia, Liberia. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.02.010DOI Listing
February 2019

Biodegradation potential of polycyclic aromatic hydrocarbons by immobilized Klebsiella sp. in soil washing effluent.

Chemosphere 2019 Feb 1;223:140-147. Epub 2019 Feb 1.

Key Laboratory of Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, Chongqing University, Chongqing, 400045, China; National Centre for International Research of Low-carbon and Green Buildings, Chongqing University, Chongqing, 400045, China. Electronic address:

A strain KL (Klebsiella sp.), with a high polycyclic aromatic hydrocarbons (PAHs) degradation efficiency, was isolated and purified. Immobilization of strain KL using a boric acid-CaCl cross-linking method based on polyvinyl alcohol (PVA)-sodium alginate (SA)-nano alumina (ALNPs) composite was investigated for removal of phenanthrene (PHE), fluoranthene (FLA), and pyrene (PYR) in soil washing effluent. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.196DOI Listing
February 2019

Seasonal mobility of antimony in sediment-water systems in algae- and macrophyte-dominated zones of Lake Taihu (China).

Chemosphere 2019 Feb 5;223:108-116. Epub 2019 Feb 5.

International Network for Environment and Health, School of Geography and Archaeology & Ryan Institute, National University of Ireland, Galway, Ireland.

Differences in trophic status can lead to different water quality and sediment geochemistry characteristics, influencing antimony (Sb) mobility in sediments and its release into the water column. In this study, seasonal sampling was conducted in algal- and macrophyte-dominated zones of Lake Taihu, China. High-resolution dialysis (HR-Peeper) and diffusive gradients in thin films (DGT) techniques were used to measure soluble Sb and DGT-labile Sb in the sediment-water profiles at a 4 mm vertical resolution. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.02.013DOI Listing
February 2019

Silicic acid: The omniscient molecule.

Sci Total Environ 2019 Feb 14;665:432-437. Epub 2019 Feb 14.

Kimika Fakultatea, Euskal Herriko Unibertsitatea (UPV/EHU), and Donostia International Physics Center (DIPC), P.K. 1072, 20080 Donostia, Euskadi, Spain. Electronic address:

We contend that silicic acid is a much under-valued molecule and specifically in the context of its role in establishing and maintaining life on Earth. Silicic acid can also be an ill-understood molecule with its chemistry all too often confused with that of either silicates or silica. Herein we (i) provide a working definition for silicic acid; (ii) identify its omnipresent role in biochemical evolution in excluding aluminium from biota and providing adventitious benefits through biological silicification and (iii) explain how the silicic acid cycle is intrinsic to climate change. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.197DOI Listing
February 2019

Estimating nitrogen flows of agricultural soils at a landscape level - A modelling study of the Upper Enns Valley, a long-term socio-ecological research region in Austria.

Sci Total Environ 2019 Feb 5;665:275-289. Epub 2019 Feb 5.

International Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, A-2361 Laxenburg, Austria; Institute of Environmental Engineering, University of Zielona Góra, Licealna 9, PL 65-417 Zielona Góra, Poland. Electronic address:

This paper explores the fate of reactive nitrogen (Nr) on the landscape scale of present agricultural production practice on arable and grassland soils. We use the soil modelling tool LandscapeDNDC (landscape scale DeNitrification-DeComposition model) to quantify resulting flows of Nr distributed to the atmosphere, hydrosphere and the crops. Test area is a watershed in the Austrian Alps characterized by arable production in the low-lying areas and grassland in the mountains. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.071DOI Listing
February 2019

Planning of births and maternal, child health, and nutritional outcomes: recent evidence from India.

Public Health 2019 Feb 14;169:14-25. Epub 2019 Feb 14.

International Center for Research on Women (ICRW), New Delhi, India. Electronic address:

Objectives: In an effort to provide recommendation for maximizing synergy between maternal, infant, and young children's nutrition and family planning in India, this study makes a comprehensive assessment of the effects of the planning of births in terms of timing, spacing and limiting childbearing on maternal and child health outcomes.

Study Design: This study used the latest National Family Health Survey data of India that is globally known as the Demographic and Health Survey. A robust two-stage systematic random sampling was used for selecting representative samples for measuring demographic and health indicators. Read More

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http://dx.doi.org/10.1016/j.puhe.2018.11.019DOI Listing
February 2019

Copy-number variation in goat genome sequence: A comparative analysis of the different litter size trait groups.

Gene 2019 Feb 14. Epub 2019 Feb 14.

College of Animal Science and Technology, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao 266109, China; College of Life Sciences, Qingdao Agricultural University, Qingdao 266109, China. Electronic address:

Copy number variation (CNV), as an important component of genomic structural variation (SV), plays essential roles in phenotypic variability, disease susceptibility and species evolution. To investigate whether critical CNVs exist in dairy goats with differing fecundity, we performed genome-wide sequencing of two populations of Laoshan dairy goats with large differences in litter size. After reference genome aligning, CNV calling, and annotation, we screened identified CNVs in the high-fecundity (HF) and low-fecundity (LF) groups to identify discrepant CNVs and their distribution within the genome. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.027DOI Listing
February 2019

Hematopoietic stem cell transplantation for mucopolysaccharidoses; past, present, and future.

Biol Blood Marrow Transplant 2019 Feb 14. Epub 2019 Feb 14.

Nemours/ Alfred I. duPont Hospital for Children, Wilmington, DE, USA; Department of Pediatrics, Shimane University Faculty of Medicine, Shimane, Japan; Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan; Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA. Electronic address:

Allogenic hematopoietic stem cell transplantation (HSCT) has been shown to be a treatment option for a selected group of patients with mucopolysaccharidoses (MPS) (MPS I, II, IVA, VI, and VII). Early diagnosis and timely referral to an expert in MPS are critical, followed by a complete examination and evaluation with a multidisciplinary team, including a transplant physician. Treatment recommendations for MPS are based on multiple factors such as biological, sociological, and financial effects. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.012DOI Listing
February 2019

Quantitative label-free mass spectrometry using contralateral and adjacent breast tissues reveal differentially expressed proteins and their predicted impacts on pathways and cellular functions in breast cancer.

J Proteomics 2019 Feb 14. Epub 2019 Feb 14.

Genetics Department, Federal University of Parana, Curitiba, Brazil. Electronic address:

Proteins play an essential role in the biological processes associated with cancer. Their altered expression levels can deregulate critical cellular pathways and interactive networks. In this study, the mass spectrometry-based label-free quantification followed by functional annotation was performed to investigate the most significant deregulated proteins among tissues of primary breast tumor (PT) and axillary metastatic lymph node (LN) and corresponding non-tumor tissues contralateral (NCT) and adjacent (ANT) from patients diagnosed with invasive ductal carcinoma. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.02.007DOI Listing
February 2019

Detection of mcr-1-mediated colistin resistance in E. coli isolate from imported chicken meat from Brazil.

J Glob Antimicrob Resist 2019 Feb 14. Epub 2019 Feb 14.

Department of Bacteriology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan; Laboratory of Bacterial Drug Resistance, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

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http://dx.doi.org/10.1016/j.jgar.2019.02.004DOI Listing
February 2019

Effects of sodium nitroprusside in the acute dizocilpine (MK-801) animal model of schizophrenia.

Brain Res Bull 2019 Feb 14. Epub 2019 Feb 14.

Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, No.388, Jianshe Middle Road, Xinxiang, 453002, Henan, People's Republic of China; Henan Key Lab of Biological Psychiatry of Xinxiang Medical University, Xinxiang, People's Republic of China; International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang, People's Republic of China. Electronic address:

Schizophrenia treatment remains a major challenge, especially the associated cognitive impairments, as these are not consistently alleviated by conventional antipsychotics. Recent animal and clinical studies suggest that the nitric oxide (NO) donor sodium nitroprusside (SNP) reduces the psychiatric symptoms and cognitive deficits of schizophrenia.The present study was designed to investigate the efficacy of SNP against schizophrenia-like behavioral and cognitive deficits in the dizocilpine (MK-801) rat model. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.008DOI Listing
February 2019

Safety and efficacy of lixisenatide versus sulfonylurea added to basal insulin treatment in people with type 2 diabetes mellitus who elect to fast during Ramadan (LixiRam): An international, randomized, open-label trial.

Diabetes Res Clin Pract 2019 Feb 14. Epub 2019 Feb 14.

University Hospital Birmingham & Institute of Translational Medicine, Edgbaston, Birmingham, UK. Electronic address:

Aims: Adding lixisenatide to basal insulin (BI) instead of sulfonylurea (SU), versus continuing SU + BI was assessed in people with type 2 diabetes mellitus (T2DM) who intended to fast during Ramadan 2017.

Methods: LixiRam (NCT02941367) was a phase 4, randomized, open-label, 12-22-week study in people with T2DM insufficiently controlled with SU + BI ± 1 oral anti-diabetic. Endpoints included the percentage of participants with ≥1 documented symptomatic hypoglycemia event (plasma glucose ≤70 mg/dL; primary endpoint) and any hypoglycemia during Ramadan fasting. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.035DOI Listing
February 2019

Defining a "High Volume" Radical Cystectomy Hospital: Where Do We Draw the Line?

Eur Urol Focus 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA.

Background: Centralization of radical cystectomy (RC) to "high volume" centers can lead to decreased morbidity but also limits access to care. In the context of centralization, there is a need to systematically define the hospital volume cutoffs for this procedure.

Objective: To systematically examine the effect of hospital volume on inpatient complications of RC for bladder cancer and to define a threshold to minimize RC morbidity. Read More

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http://dx.doi.org/10.1016/j.euf.2019.02.001DOI Listing
February 2019

Essential Research Priorities in Renal Cancer: A Modified Delphi Consensus Statement.

Eur Urol Focus 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK. Electronic address:

Background: Identification of clear and focused research priorities is crucial to drive research forward.

Objective: To identify research priorities in renal cell carcinoma (RCC) through a multidisciplinary collaboration between clinicians, researchers, and patients.

Design, Setting, And Participants: In phase I, 44 RCC experts provided 24 literature reviews within their field, summarising research gaps (RGs). Read More

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http://dx.doi.org/10.1016/j.euf.2019.01.014DOI Listing
February 2019

Association of vitamin D deficiency with insulin resistance in middle-aged type 2 diabetics.

Clin Chim Acta 2019 Feb 14. Epub 2019 Feb 14.

Symbiosis School of Biological Sciences (Formerly Symbiosis School of Biomedical Sciences), Symbiosis International University, India.

Background: Vitamin D deficiency contributes to the pathophysiology of insulin resistance (IR) and type 2 diabetes mellitus (T2DM). We investigated the association of 25-hydroxyvitamin D [25(OH)D] with IR and β-cell function in middle-aged participants.

Methods: We enrolled 90 controls and 90 T2DM patients of both genders aged 30-50 y. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.014DOI Listing
February 2019

A genomewide transcriptomic approach identifies a novel gene expression signature for the detection of lymph node metastasis in patients with early stage gastric cancer.

EBioMedicine 2019 Feb 13. Epub 2019 Feb 13.

Center for Gastrointestinal Research, Baylor Scott & White Research Institute and Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, TX, USA. Electronic address:

Background: Although identification of lymph node (LN) metastasis is a well-recognized strategy for improving outcomes in patients with gastric cancer (GC), currently there is lack of availability of adequate molecular biomarkers that can identify such metastasis. Herein we have developed a robust gene-expression signature for detecting LN metastasis in early stage GC by using a transcriptome-wide biomarker discovery and subsequent validation in multiple clinical cohorts.

Methods: A total of 532 patients with pathological T1 and T2 GC from 4 different cohorts were analyzed. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.01.057DOI Listing
February 2019

General and abdominal adiposity and the risk of Parkinson's disease: A prospective cohort study.

Parkinsonism Relat Disord 2019 Feb 8. Epub 2019 Feb 8.

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Germany. Electronic address:

Introduction: Due to demographic change, an increase in the frequency of Parkinson's disease (PD) patients is expected in the future and, thus, the identification of modifiable risk factors is urgently needed. We aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with incident PD.

Methods: In 13 of the 23 centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a total of 734 incident cases of PD were identified between 1992 and 2012 with a mean follow-up of 12 years. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.019DOI Listing
February 2019

Development of evidence-based quality indicators for deep brain stimulation in patients with Parkinson's disease and first year experience of implementation of a nation-wide registry.

Parkinsonism Relat Disord 2019 Feb 5. Epub 2019 Feb 5.

Institute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany; Comprehensive Heart Failure Center, University Würzburg, Clincial Trial Center Würzburg, University Hospital Würzburg, Germany.

Introduction: Deep Brain Stimulation (DBS) is a complex, invasive and cost-intensive therapy that requires a high level of expertise. To date, data on quality of DBS in clinical routine in the German health care system are lacking.

Methods: The development of evidence-based QIs for DBS in PD patients was performed following a standardized process by a multidisciplinary board between 2014 and 2016. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.016DOI Listing
February 2019

Impact of Disagreement Between Two Risk Group Models on Prognosis in Patients With Metastatic Renal-Cell Carcinoma.

Clin Genitourin Cancer 2019 Jan 17. Epub 2019 Jan 17.

Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Purpose: To investigate the impact of the risk group disagreement between the Memorial Sloan Kettering Cancer Center (MSKCC) and the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) models on prognosis.

Patients And Methods: We retrospectively evaluated 176 patients with metastatic renal-cell carcinoma who were treated with tyrosine kinase inhibitors as first-line therapy in 5 hospitals between October 2008 and August 2018. The risk group classification differences between the MSKCC and the IMDC models were evaluated using criteria of agreement (identical risk group in both the MSKCC and IMDC models) and disagreement (not identical risk group in both the MSKCC and IMDC models). Read More

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http://dx.doi.org/10.1016/j.clgc.2019.01.006DOI Listing
January 2019

An Environmental Scan of the National and Provincial Diagnostic Reference Levels in Canada for Common Adult Computed Tomography Scans.

Can Assoc Radiol J 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology, McMaster University, Hamilton, Ontario, Canada.

Several regulatory bodies have agreed that low-dose radiation used in medical imaging is a weak carcinogen that follows a linear, non-threshold model of cancer risk. While avoiding radiation is the best course of action to mitigate risk, computed tomography (CT) scans are often critical for diagnosis. In addition to the as low as reasonably achievable principle, a more concrete method of dose reduction for common CT imaging exams is the use of a diagnostic reference level (DRL). Read More

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http://dx.doi.org/10.1016/j.carj.2018.07.005DOI Listing
February 2019

Association of total cholesterol with severe acute pancreatitis: A U-shaped relationship.

Clin Nutr 2019 Jan 31. Epub 2019 Jan 31.

Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China. Electronic address:

Background & Aims: There is no consensus on relationship between total cholesterol levels and incidence of severe acute pancreatitis (SAP). The aim of this study was to investigate the relation between total cholesterol (TC) and the disease severity of acute pancreatitis.

Methods: We conducted a cross-sectional study on patients with acute pancreatitis between April 2012 and December 2015 in a university hospital. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.01.022DOI Listing
January 2019

Nutrition education in medical schools (NEMS). An ESPEN position paper.

Clin Nutr 2019 Feb 7. Epub 2019 Feb 7.

Department of Gastroenterology and Nutritional Support, Hopital Erasme and Institut Bordet, Free University of Brussels, Brussels, Belgium.

Background & Aims: Nutrition education is necessary in the training of healthcare professionals, including medical students. However, recent surveys showed that there is a high variability within Medical Schools in different countries. The aim of this ESPEN position paper is to identify a minimum curriculum knowledge in nutrition that serves to improve the training of the future doctors and how to solve the main barriers of its implementation in university centres. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.02.001DOI Listing
February 2019

Impact of the introduction of the Haemophilus influenzae type b conjugate vaccine in an urban setting in southern India.

Vaccine 2019 Feb 13. Epub 2019 Feb 13.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21218, USA.

Introduction: Haemophilus influenzae type b was the leading cause of bacterial meningitis in infants and children below the age of two years prior to the introduction of H. influenzae type b conjugate vaccines. In December 2011, the Indian government introduced H. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.080DOI Listing
February 2019

Anomalous aortic origin of coronary arteries: Early results on clinical management from an international multicenter study.

Int J Cardiol 2019 Feb 10. Epub 2019 Feb 10.

Section of Pediatric and Congenital Cardiac Surgery, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Medical School, Italy.

Background: Anomalous aortic origin of coronary arteries (AAOCA) is a rare abnormality, whose optimal management is still undefined. We describe early outcomes in patients treated with different management strategies.

Methods: This is a retrospective clinical multicenter study including patients with AAOCA, undergoing or not surgical treatment. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.02.007DOI Listing
February 2019

Zika and travel in the news: a content analysis of US news stories during the outbreak in 2016-2017.

Public Health 2019 Feb 13. Epub 2019 Feb 13.

RTI International, P.O. Box 12194, Research Triangle Park, NC, USA. Electronic address:

Objectives: This study aimed to understand what information the US media communicated about Zika virus (ZIKV) and travel in 2016 and 2017.

Study Design: We conducted a content analysis of news coverage about ZIKV and travel from April 5, 2016 to March 31, 2017.

Methods: We obtained a stratified, random sample of English language, US print newspaper and television news coverage about ZIKV and travel. Read More

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http://dx.doi.org/10.1016/j.puhe.2018.12.009DOI Listing
February 2019

Frequency and risk factors of thoracic metastases and optimisation of the use of cross-sectional chest imaging in follow-up patients with cervical cancer.

Clin Radiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

Aim: To optimise cross-sectional chest imaging usage by identifying frequency and risk factors associated with thoracic metastases in cervical cancer patients after initial definitive treatment.

Materials And Methods: This study, conducted during 2004-2015, examined 361 consecutive patients with histopathologically proven cervical carcinoma with at least 1 year of follow-up. Electronic medical records and all available imaging modes were used to record and assess patient and tumour characteristics and timing of thoracic metastases. Read More

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http://dx.doi.org/10.1016/j.crad.2018.11.014DOI Listing
February 2019