1,639 results match your criteria International heart journal[Journal]


Impaired Flow-Mediated Dilation and Severity and Vulnerability of Culprit Plaque in Patients with Coronary Artery Disease.

Int Heart J 2019 Apr 10. Epub 2019 Apr 10.

Department of Cardiovascular Medicine, Kitasato University School of Medicine.

The association between endothelial function, evaluated using flow-mediated dilatation (FMD), and the severity of coronary artery disease remains to be elucidated.A total of 245 consecutive patients with stable angina were prospectively enrolled. FMD was evaluated in the brachial artery before percutaneous coronary intervention. Read More

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http://dx.doi.org/10.1536/ihj.18-531DOI Listing

Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic Cardiomyopathy.

Int Heart J 2019 Apr 10. Epub 2019 Apr 10.

Department of Anesthesiology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou.

Diabetic cardiomyopathy is one of the main causes of heart failure and death in patients with diabetes mellitus. Reactive oxygen species produced excessively in diabetes mellitus cause necrosis, apoptosis, ferroptosis, inflammation, and fibrosis of the myocardium as well as impair the cardiac structure and function. It is increasingly clear that oxidative stress is a principal cause of diabetic cardiomyopathy. Read More

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http://dx.doi.org/10.1536/ihj.18-476DOI Listing
April 2019
1 Read

Early Tissue Reaction After Second-Generation Cryoballoon Ablation Evaluated with Intracardiac Echocardiography.

Int Heart J 2019 Apr 10. Epub 2019 Apr 10.

Cardiovascular Center, Tsuchiura Kyodo Hospital.

Radiofrequency energy applications immediately produce tissue edema. This study aimed to investigate the acute tissue reaction immediately after second-generation cryoballoon applications using 3-dimensional intracardiac echocardiography (ICE) imaging technology.This study consisted of 10 patients with paroxysmal atrial fibrillation who underwent pulmonary vein isolation (PVI) using second-generation cryoballoons. Read More

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http://dx.doi.org/10.1536/ihj.18-413DOI Listing
April 2019
1 Read

Endothelin-1 and Atrial Cardiomyopathy.

Int Heart J 2019 ;60(2):238-240

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

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http://dx.doi.org/10.1536/ihj.19-039DOI Listing
January 2019

Thrombospondin-2.

Int Heart J 2019 ;60(2):235-237

Department of Cardiovascular Medicine, The University of Tokyo Hospital.

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http://dx.doi.org/10.1536/ihj.19-042DOI Listing
January 2019

Right Heart is a Key to Response to Adaptive Servo-Ventilation Therapy.

Authors:
Teruhiko Imamura

Int Heart J 2019 Mar 22;60(2):492. Epub 2019 Feb 22.

Division of Cardiology, Department of Medicine, University of Chicago Medical Center.

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http://dx.doi.org/10.1536/ihj.18-608DOI Listing
March 2019
2 Reads

Clinical Implications of Baroreflex Sensitivity in Type 2 Diabetes.

Int Heart J 2019 Mar 22;60(2):241-246. Epub 2019 Feb 22.

Department of Cardiology, Jikei University School of Medicine.

The evaluation of baroreflex sensitivity (BRS), which maintains systemic circulatory homeostasis, is an established tool to assess cardiovascular autonomic neuropathy in type 2 diabetes mellitus (T2DM). As BRS plays an important function in blood pressure regulation, reduced BRS leads to an increase in blood pressure variability, which further leads to reduced BRS. This sequence of events becomes a vicious cycle. Read More

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http://dx.doi.org/10.1536/ihj.18-455DOI Listing

Independent Prognostic Value of Pulmonary Diffusing Capacity in Nonsmoking Patients with Chronic Heart Failure.

Int Heart J 2019 Mar 22;60(2):366-373. Epub 2019 Feb 22.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center.

The diffusing capacity of the lung for carbon monoxide (DLCO) is indicative of the alveolar-capillary membrane function. A reduced DLCO is associated with poor prognosis in chronic heart failure (HF). However, the significance of DLCO as an independent prognostic predictor has not been established. Read More

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http://dx.doi.org/10.1536/ihj.18-420DOI Listing
March 2019
2 Reads

Additional Value of Early Repolarization Pattern in Prediction of Obstructive Coronary Artery Disease as Assessed by Coronary Angiography.

Int Heart J 2019 Mar 22;60(2):296-302. Epub 2019 Feb 22.

Department of Cardiology, the Eastern Hospital of the First Affiliated Hospital, Sun Yat-Sen University.

Recent reports show that an early repolarization pattern (ERP) is associated with a higher incidence of sudden cardiac death in patients with obstructive coronary artery disease (CAD). Sporadic case studies have pointed out that ERP might be related to obstructive CAD.In consecutive patients who had undergone coronary angiography, we investigated the relationship between ERP and obstructive CAD by evaluating its association with coronary artery stenosis. Read More

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http://dx.doi.org/10.1536/ihj.18-416DOI Listing

Rescue Percutaneous Coronary Intervention for a Lethal "Jailed" Septal Perforator Branch to Resolve Delayed Complete Atrioventricular Block.

Int Heart J 2019 Mar 22;60(2):457-461. Epub 2019 Feb 22.

Department of Cardiology, Nishinomiya Municipal Central Hospital.

Delayed complete atrioventricular (AV) block associated with an occluded septal perforator branch (SPB) is an uncommon complication after performing percutaneous coronary intervention (PCI) for the left anterior descending coronary artery (LAD). Here we report the case of a 74-year-old man who underwent elective PCI for proximal LAD complicated with occlusion of the first major SPB and developed a complete AV block 78 hours after PCI was performed. The patient received a temporary transvenous pacemaker via the jugular vein and successfully underwent balloon angioplasty of the lethal "jailed" SPB, resulting in recovery from the complete AV block. Read More

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http://dx.doi.org/10.1536/ihj.18-280DOI Listing
March 2019
2 Reads

Electrophysiological Measurement of Rat Atrial Epicardium Using a Novel Stereotaxic Apparatus.

Int Heart J 2019 Mar 22;60(2):400-410. Epub 2019 Feb 22.

Department of Cardiology, The Second Affiliate Hospital of Xi'an Jiaotong University.

Flexible, in vivo maneuverable electrophysiology mapping techniques are not available in rat models. A novel cardiac stereotactic electrophysiology epicardial mapping system (CREAMS) allows for various measurements, including: (1) recording unipolar electrograms at multiple sites; (2) positioning of mapped sites and precision testing (Distance between the two "centers" = 297 ± 54 μm, n = 15); (3) evaluation of electrophysiology in an in vivo Sprague-Dawley rat model with high-frequency stimulation (HFS)-induced Atrial fibrillation (AF) at high right atrium (HRA) sites. We found that of the right atrium dispersion of effective refractory period (P < 0. Read More

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http://dx.doi.org/10.1536/ihj.18-215DOI Listing
March 2019
1.127 Impact Factor

Atrial Septal Defect of the Ostium Secundum Type in A 101-Year-Old Patient.

Int Heart J 2019 Mar 22;60(2):489-491. Epub 2019 Feb 22.

Department of Cardiology, Juntendo University.

The patient was a 101-year-old woman whose chief complaints were difficulty of breathing and high fever. The history of the present illness included paroxysmal atrial flutter which was untreated, but she had not developed heart failure.At admission, auscultation of the chest revealed moist rales and systolic murmur but did not clearly show the presence of fixed splitting of S2. Read More

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http://dx.doi.org/10.1536/ihj.18-354DOI Listing

Combined Mitral and Aortic Valve Procedure via Right Mini-Thoracotomy versus Full Median Sternotomy.

Int Heart J 2019 Mar 22;60(2):336-344. Epub 2019 Feb 22.

Shanghai Institute of Cardiovascular Disease.

Data involving combined mitral and aortic valve procedure via the right mini-thoracotomy approach are very limited. This single-center propensity-matching study aimed to evaluate early clinical outcomes of patients who underwent combined mitral and aortic valve procedure via right mini-thoracotomy versus full median sternotomy.From January 2013 to December 2016, 926 eligible patients in our center were identified for this study. Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-186DOI Listing
March 2019
9 Reads

The Relationship of Appetite-Regulating Hormones in the Development of Cardiac Cachexia.

Int Heart J 2019 Mar 22;60(2):384-391. Epub 2019 Feb 22.

Laboratory of Cardiovascular Medicine, Department of Internal Medicine, First Affiliated Hospital, Harbin Medical University.

The physiological control of appetite regulation involves circulating hormones with orexigenic (ghrelin) and anorexigenic (cholecystokinin) properties that induce alterations in energy intake via perceptions of hunger and satiety. We sought to investigate the relationship between appetite-regulating hormones and the cachexia associated with chronic heart failure.We randomized male Sprague-Dawley rats into myocardial infarction (MI) or sham operation (SO) groups. Read More

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http://dx.doi.org/10.1536/ihj.18-131DOI Listing
March 2019
2 Reads

Architecture of the Japan Ischemic Heart Disease Multimodal Prospective Data Acquisition for Precision Treatment (J-IMPACT) System.

Int Heart J 2019 Mar 22;60(2):264-270. Epub 2019 Feb 22.

Jichi Medical University.

The utilization of electronic medical records and multimodal medical data is an ideal approach to build a real-time and precision registry type study with a smaller effort and cost, which may fill a gap between evidence-based medicine and the real-world clinical practice. The Japan Ischemic heart disease Multimodal Prospective data Acquisition for preCision Treatment (J-IMPACT) project aimed to build an clinical data registry system that electronically collects not only medical records, but also multimodal data, including coronary angiography and percutaneous coronary intervention (PCI) report, in standardized data formats for clinical studies.The J-IMPACT system comprises the standardized structured medical information exchange (SS-MIX), coronary angiography and intervention reporting system (CAIRS), and multi-purpose clinical data repository system (MCDRS) interconnected within the institutional network. Read More

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http://dx.doi.org/10.1536/ihj.18-113DOI Listing
March 2019
1 Read

Efficacy of IntraCoronary Erythropoietin Delivery BEfore Reperfusion-Gauging Infarct Size in Patients with Acute ST-segment Elevation Myocardial Infarction (ICEBERG).

Int Heart J 2019 Mar 22;60(2):255-263. Epub 2019 Feb 22.

Department of Internal Medicine, Seoul National University College of Medicine, Cardiovascular Center, Seoul National University Bundang Hospital.

Previous clinical studies have shown inconsistent results regarding the effect of erythropoietin in ST-segment elevation myocardial infarction (STEMI). This study investigated whether directed intracoronary infusion of darbepoetin-α into ischemic myocardium before reperfusion would reduce infarct size or post-infarct remodeling in STEMI patients.Eighty STEMI patients received one of the following treatments simultaneously with the first balloon inflation: intracoronary darbepoetin-α 300 μg (n = 40) or saline (n = 40), administered via the over-the-wire balloon system. Read More

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http://dx.doi.org/10.1536/ihj.18-035DOI Listing
March 2019
2 Reads

Safe Hydration to Prevent Contrast-Induced Acute Kidney Injury and Worsening Heart Failure in Patients with Renal Insufficiency and Heart Failure Undergoing Coronary Angiography or Percutaneous Coronary Intervention.

Int Heart J 2019 Mar 22;60(2):247-254. Epub 2019 Feb 22.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences.

An optimal hydration volume (HV) that prevents contrast-induced acute kidney injury (CI-AKI) in patients with renal insufficiency and heart failure (HF) at a high risk of worsening HF (WHF) has not been determined. We aimed to determine a safe HV that prevents CI-AKI and WHF following coronary angiography (CAG) or percutaneous coronary intervention (PCI) in patients with renal insufficiency and HF. We recruited 1,307 patients with renal insufficiency and HF and investigated the relationships between the peri-procedural HV/weight (HV/W) ratio, and the risks of CI-AKI and WHF following CAG or PCI. Read More

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http://dx.doi.org/10.1536/ihj.17-066DOI Listing
March 2019
1 Read
1.127 Impact Factor

Murine Model of Pulmonary Artery Overflow Vasculopathy Revealed Macrophage Accumulation in the Lung.

Int Heart J 2019 Mar 22;60(2):451-456. Epub 2019 Feb 22.

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of unresolved pulmonary embolism or clots in the pulmonary arteries. The obstruction not only reduces the area of the pulmonary vascular bed, but also elicits high pressure and high shear stress in the spared unobstructed arteries. Subsequent overflow of the small pulmonary arteries induces vascular remodeling, termed as overflow vasculopathy (OV). Read More

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http://dx.doi.org/10.1536/ihj.18-281DOI Listing
March 2019
2 Reads

Pulseless Electric Activity with Pre-Excitation.

Int Heart J 2019 Mar 8;60(2):470-473. Epub 2019 Feb 8.

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

A 41-year-old man developed cardiac arrest. A resting 12-lead electrocardiogram showed a delta wave, suggestive of preexcitation syndrome. An electrophysiological test revealed the existence of inducible atrial fibrillation and a fasciculoventricular accessory pathway (FVAP). Read More

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http://dx.doi.org/10.1536/ihj.18-546DOI Listing
March 2019
5 Reads

Outcomes of Transcatheter Aortic Valve Implantation in Patients with Cirrhosis.

Int Heart J 2019 Mar 8;60(2):352-358. Epub 2019 Feb 8.

Department of Cardiology, Sakakibara Heart Institute.

Cirrhosis is a significant adverse factor of cardiac surgeries. Transcatheter aortic valve implantation (TAVI) has evolved as a less invasive therapy for aortic stenosis, whereas detailed case analysis of TAVI in cirrhotic patients is limited.Among 444 consecutive patients who underwent TAVI in the Sakakibara Heart Institute between October 2013 and January 2018, we retrospectively reviewed 11 patients (2. Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-339DOI Listing
March 2019
11 Reads

Impact of the Temporal Distribution of Coronary Artery Disease Progression on Subsequent Consequences in Patients with Acute Coronary Syndrome.

Int Heart J 2019 Mar 8;60(2):287-295. Epub 2019 Feb 8.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine.

The late consequences of acute coronary syndrome (ACS) have been underestimated. We hypothesized that the temporal distribution of the clinically silent coronary artery disease progression (CP) is associated with the subsequent consequences of ACS.We studied 243 patients (202 men, 64 ± 10 years) with ACS undergoing percutaneous coronary intervention (PCI) during initial hospitalization. Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-394DOI Listing
March 2019
8 Reads

Subcutaneous Implantable Cardioverter Defibrillator Lead Repositioning for Preventing Inappropriate Shocks Due to Myopotential Oversensing in a Post-Fulminant Myocarditis Patient.

Int Heart J 2019 Mar 8;60(2):466-469. Epub 2019 Feb 8.

Division of Cardiology, Gunma Prefectural Cardiovascular Center.

A 28-year-old female presented with fulminant lymphocytic myocarditis. She developed cardiogenic shock, frequent sustained ventricular tachycardia, and fibrillation (VT and VF). The left ventricular ejection fraction improved from 5% to 40% after medical therapy, but the right ventricular systolic dysfunction and enlargement persisted. Read More

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http://dx.doi.org/10.1536/ihj.18-324DOI Listing
March 2019
2 Reads

Changes in Autophagy Levels in Rat Myocardium During Exercise Preconditioning-Initiated Cardioprotective Effects.

Int Heart J 2019 Mar 8;60(2):419-428. Epub 2019 Feb 8.

School of Kinesiology, Shanghai University of Sport.

The role of autophagy in the cardioprotection conferred by ischemic preconditioning (IPC) has been well described. This study aimed to investigate the changes in autophagy levels during the cardioprotective effects initiated by exercise preconditioning (EP).Rats were randomly divided into 4 groups: group C (control), group EP, group EE (exhaustive exercise), and group EP + EE (EP pretreatment at 0. Read More

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http://dx.doi.org/10.1536/ihj.18-310DOI Listing
March 2019
3 Reads

Serum Circulating miR-150 is a Predictor of Post-Acute Myocardial Infarction Heart Failure.

Int Heart J 2019 Mar 8;60(2):280-286. Epub 2019 Feb 8.

Experimental Teaching Center, School of Basic Medical Sciences, Zhejiang University.

Patients with ischemic heart disease are associated with poor prognosis, and their number has increased globally. Therefore, biomarkers that could predict post-acute myocardial infarction (AMI) heart failure (HF) would be helpful to guide appropriate treatment. Based on the diagnosis on admission and results of echocardiogram performed on admission and 1 year after discharge, the current study recruited 54 patients with post-AMI HF, 59 patients with post-AMI non-HF, and 59 healthy controls. Read More

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http://dx.doi.org/10.1536/ihj.18-306DOI Listing
March 2019
1 Read

Intravenous Immunoglobulin Therapy for Acute Myocarditis in Children and Adults.

Int Heart J 2019 Mar 8;60(2):359-365. Epub 2019 Feb 8.

Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology.

The efficacy of intravenous immunoglobulin (IVIG) in the treatment of acute myocarditis remains controversial. The aim of this study was to conduct a meta-analysis to assess the efficacy of IVIG in children and adults with acute myocarditis.We searched PubMed, Scopus, Embase, Medline, the Cochrane Library, Google Scholar, and the ClinicalTrials. Read More

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http://dx.doi.org/10.1536/ihj.18-299DOI Listing
March 2019
2 Reads

A Decision Tree-Based Survival Analysis of Patients with a History of Inappropriate Implantable Cardioverter-Defibrillator Therapy.

Int Heart J 2019 Mar 8;60(2):318-326. Epub 2019 Feb 8.

Department of Cardiology, Fujita Health University School of Medicine.

Implantable cardioverter-defibrillators (ICDs) improve survival in patients who are at risk of sudden death. However, inappropriate therapy is commonly given to ICD recipients, and this situation may be associated with an increased risk of death. This study aimed to construct a risk stratification scheme by using decision tree analysis in patients who received inappropriate ICD therapy. Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-288DOI Listing
March 2019
10 Reads

Thrombospondin-2 as a Potential Risk Factor in a General Population.

Int Heart J 2019 Mar 8;60(2):310-317. Epub 2019 Feb 8.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine Kurume.

Serum thrombospondin-2 (TSP-2) is a glycoprotein expressed in the extracellular matrix (ECM), which increases during tissue remodeling. It has been shown in recent studies that TSP-2 is a useful predictor of cardiovascular death in patients with heart failure (HF). However, the clinical importance of serum TSP-2 levels in a general population is still unknown. Read More

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http://dx.doi.org/10.1536/ihj.18-246DOI Listing
March 2019
6 Reads

Association of Isoprostanes-Related Oxidative Stress with Vulnerability of Culprit Lesions in Diabetic Patients with Acute Coronary Syndrome.

Int Heart J 2019 Mar 8;60(2):271-279. Epub 2019 Feb 8.

Center of Cardiology, Beijing An Zhen Hospital, Capital Medical University.

Urinary excretion of 8-iso-prostaglandin F (8-iso-PGF), a reliable biomarker for enhanced oxidant stress in vivo, has been described in association with diabetes and coronary heart disease. The aim of this study was to evaluate the relationship between urinary 8-iso-PGF levels and the characteristics of coronary culprit lesion in diabetic patients with acute coronary syndrome (ACS). A total of 79 diabetic patients with ACS were included. Read More

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http://dx.doi.org/10.1536/ihj.18-233DOI Listing
March 2019
1 Read

Predictive Roles of Neutrophil-to-Lymphocyte Ratio and C-Reactive Protein in Patients with Calcific Aortic Valve Disease.

Int Heart J 2019 Mar 8;60(2):345-351. Epub 2019 Feb 8.

Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong University.

The neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) are emerging indirect blood markers to roughly reflect the inflammation level in our body while some pathological changes occurring in aortic valve tissue. Few recent studies demonstrated that NLR is related to calcific aortic valve disease (CAVD). However, the extent of the relationship between them and the impact of CRP on CAVD are not clear. Read More

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http://dx.doi.org/10.1536/ihj.18-196DOI Listing
March 2019
2 Reads

Modulation of the Proliferation/Apoptosis Balance of Vascular Smooth Muscle Cells in Atherosclerosis by lncRNA-MEG3 via Regulation of miR-26a/Smad1 Axis.

Int Heart J 2019 Mar 8;60(2):444-450. Epub 2019 Feb 8.

Department of Cardiothoracic Surgery, Nanjing First Hospital, Nanjing Heart Institute, Nanjing Medical University.

The balance between proliferation and apoptosis of vascular smooth muscle cells (VSMCs) plays a critical role in the initiation of atherosclerosis. LncRNA-MEG3 is involved in the pathophysiology of atherosclerosis through regulation of endothelial cell proliferation and migration. Its effect on the dysfunction of VSMCs and the corresponding mechanisms are actively researched. Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-195DOI Listing
March 2019
18 Reads

Antithrombotic Treatment May Reduce Mortality Among New-Onset Atrial Fibrillation Patients with Gray-Zone Risk of Stroke.

Int Heart J 2019 Mar 8;60(2):303-309. Epub 2019 Feb 8.

Division of Cardiology, Department of Medicine, Chung Shan Medical University Hospital and Chung Shan Medical University.

In clinical practice, some atrial fibrillation (AF) patients were classified as having low and moderate stroke risk by the CHADS score (≤ 1) in 2001 but in 2012 they were not truly classified as low risk of stroke according to the CHADS-VASc score (≥ 2) (defined gray zone). Therefore, a treatment gap exists in gray zone AF patients. This study aimed to evaluate whether gray zone AF patients could benefit from reduced all-cause mortality under antithrombotic treatment. Read More

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http://dx.doi.org/10.1536/ihj.18-174DOI Listing
March 2019
5 Reads

Different Clinical Presentation and Tissue Characterization in a Monozygotic Twin Pair with MYH7 Mutation-Related Hypertrophic Cardiomyopathy.

Int Heart J 2019 Mar 8;60(2):477-481. Epub 2019 Feb 8.

Division of Cardiology, West China Hospital, Sichuan University.

This case report demonstrates a pair of monozygotic twins with hypertrophic cardiomyopathy (HCM) carrying the same pathogenic mutation of MYH7 (p.G768R; c.2302G>A), detected by whole exome and Sanger genetic sequencing methods. Read More

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http://dx.doi.org/10.1536/ihj.18-167DOI Listing
March 2019
2 Reads

Linagliptin Suppresses Electrical and Structural Remodeling in the Isoproterenol Induced Myocardial Injury Model.

Int Heart J 2019 Mar 8;60(2):411-418. Epub 2019 Feb 8.

Department of Cardiovascular Medicine, Kitasato University School of Medicine.

The effect of DPP-4 inhibitor on the electrical and structural remodeling in myocardial injury has not been evaluated. We hypothesized that linagliptin, DPP-4 inhibitor, suppresses myocardial remodeling in the isoproterenol (ISP)-induced myocardial injury model.Sprague-Dawley rats were assigned to 3 groups: 1) sham group, 2) ISP group (subcutaneous ISP injection of 70 mg/kg), and 3) ISP + linagliptin (ISP + Lin) (5 mg/kg/day, p. Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-226DOI Listing
March 2019
5 Reads

Cyclin Dependent Kinase 1 (CDK1) Activates Cardiac Fibroblasts via Directly Phosphorylating Paxillin at Ser244.

Int Heart J 2019 Mar 8;60(2):374-383. Epub 2019 Feb 8.

Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University.

Atrial fibrillation has caused severe burden for people worldwide. Differentiation of fibroblasts into myofibroblasts, and consequent progress in atrial structural remodeling have been considered the basis for persistent atrial fibrillation, yet little is known about the molecular mechanisms underlying the process. Here, we show that cyclin-dependent kinase 1 (CDK1) is activated in atrial fibroblasts from patients with atrial fibrillation (AFPAF) and in platelet derived growth factor BB (PDGF-BB)-treated atrial fibroblasts from patients with sinus rhythm (AFPSR). Read More

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http://dx.doi.org/10.1536/ihj.18-073DOI Listing
March 2019
6 Reads

Emodin Attenuates Lipopolysaccharide-Induced Injury via Down-Regulation of miR-223 in H9c2 Cells.

Int Heart J 2019 Mar 8;60(2):436-443. Epub 2019 Feb 8.

Department of General Medicine, East Medical District of Linyi People's Hospital.

Emodin is a natural product extracted from Rheum palmatum. There are few recent studies on emodin in the treatment of myocarditis. This study aimed to investigate the effect of emodin on lipopolysaccharide (LPS)-induced inflammatory injury in cardiomyocytes. Read More

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http://dx.doi.org/10.1536/ihj.18-048DOI Listing
March 2019
2 Reads

STAT3 Phosphorylation Mediating DMSO's Function on Fetal Cardiomyocyte Proliferation with Developmental Changes.

Int Heart J 2019 Mar 8;60(2):392-399. Epub 2019 Feb 8.

Department of Physiology, Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, School of Basic Medicine, Huazhong University of Science and Technology.

Endogenous cardiac regeneration has been focused for decades as a potential therapy for heart diseases with cell loss, and dimethyl sulfoxide (DMSO) has been proposed as a treatment for many diseases. In this study, we aimed to investigate the function of DMSO on fetal cardiomyocyte proliferation. By tracing BrdU/α actinin cells or Ki67/α actinin cells with immunohistochemical staining, we found that DMSO remarkably promoted fetal cardiomyocytes proliferation, and at the late developmental stage (LDS), such effects were more efficient than that at early developmental stage (EDS). Read More

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http://dx.doi.org/10.1536/ihj.18-206DOI Listing
March 2019
8 Reads

Interaction Between the Gut-Kidney-Cardiovascular Systems Is Key in Predicting the Prognosis of Patients with Cardiovascular Disease.

Int Heart J 2019 ;60(1):7-9

Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences.

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http://dx.doi.org/10.1536/ihj.18-672DOI Listing
January 2019

Maladaptive Alterations of Autonomic Nerve System in Cardiovascular Disorders.

Int Heart J 2019 ;60(1):4-6

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

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http://dx.doi.org/10.1536/ihj.18-677DOI Listing
January 2019

Secondary Cardiomyopathy in Polycystic Kidney Disease Syndrome.

Authors:
Hiroyuki Morita

Int Heart J 2019 ;60(1):10-11

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

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http://dx.doi.org/10.1536/ihj.18-514DOI Listing
January 2019
1 Read

Neuregulin-4, an Adipokine, as a Residual Risk Factor of Atherosclerotic Coronary Artery Disease.

Int Heart J 2019 ;60(1):1-3

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

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https://www.jstage.jst.go.jp/article/ihj/60/1/60_18-654/_art
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http://dx.doi.org/10.1536/ihj.18-654DOI Listing
January 2019
13 Reads

Rare Simultaneous Left and Right-Sided Native Valve Infective Endocarditis Caused by Rare Bacterium.

Authors:
Jian-Hong Pan

Int Heart J 2019 Mar 10;60(2):474-476. Epub 2019 Jan 10.

Department of Internal Medicine, Tianjin NanKai Hospital.

Simultaneous left and right-sided native valve infective endocarditis (IE) is rare. Staphylococcus aureus was the predominant organism for bilateral IE. Shunt diseases are common risk factors of both-sided IE. Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-347DOI Listing
March 2019
15 Reads

Assessment of Unicuspid Aortic Valve Stenosis Using Multimodality Imaging, X-ray Radiography and Raman Analysis.

Int Heart J 2019 Mar 10;60(2):482-488. Epub 2019 Jan 10.

Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology.

Unicuspid aortic valve (UAV) is an extremely rare form of congenital cardiac malformation, leading to aortic stenosis (AS), aortic regurgitation (AR), or both. We report the case of a 55-year-old man with unicommissural UAV associated with severe AS and mild AR using different multimodality imaging approaches. The excised UAV isolated after aortic valve replacement exhibited an eccentric "teardrop" opening with a slit-shaped unicommissural structure. Read More

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http://dx.doi.org/10.1536/ihj.18-338DOI Listing
March 2019
2 Reads

Iatrogenic Palpitations during Exercise in a Patient with a Dual Chamber Implantable Cardioverter-Defibrillator and Lead Dysfunction.

Int Heart J 2019 Mar 10;60(2):462-465. Epub 2019 Jan 10.

Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui.

Implantable cardioverter-defibrillators (ICDs) are an effective treatment to prevent sudden cardiac death; however, lead dysfunction is an important complication during the long-term follow-up period in ICD recipients. Careful device programming is required in accordance with the individual situation in patients with lead dysfunction. We herein present a patient in whom programming to AAI triggered palpitations during exercise. Read More

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http://dx.doi.org/10.1536/ihj.18-248DOI Listing
March 2019
2 Reads

Osteopontin in the Pathogenesis of Aortic Dissection by the Enhancement of MMP Expressions.

Int Heart J 2019 Mar 10;60(2):429-435. Epub 2019 Jan 10.

Department of Cardiothoracic Surgery, Drum Tower Clinical Medical College of Nanjing Medical University.

The pathogenesis of aortic dissection (AD) is unclear. The aim of this study was to explore the relationship between osteopontin (OPN) and AD. Fifty AD patients were enrolled; 29 had hypertension with AD (H-AD) and 21 no hypertension with HD (NH-AD). Read More

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http://dx.doi.org/10.1536/ihj.18-017DOI Listing
March 2019
3 Reads

Associations Between Multiple Circulating Biomarkers and the Presence of Atrial Fibrillation in Hypertrophic Cardiomyopathy with or Without Left Ventricular Outflow Tract Obstruction.

Int Heart J 2019 Mar 10;60(2):327-335. Epub 2019 Jan 10.

Clinical EP Lab & Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.

Atrial fibrillation (AF) is the most common arrhythmia in patients with hypertrophic cardiomyopathy (HCM). Data regarding the correlations of biomarkers and AF in HCM patients are rather limited. We sought to explore the associations between the presence of AF and circulating biomarkers reflecting cardiovascular function (N-terminal pro-brain natriuretic peptide, NT-pro BNP), endothelial function (big endothelin-1, big ET-1), inflammation (high-sensitivity C-reactive protein), and myocardial damage (cardiac troponin I, cTnI) in HCM patients with and without left ventricular outflow tract obstruction (LVOTO). Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-438DOI Listing
March 2019
11 Reads

Involvement of Apelin/APJ Axis in Thrombogenesis in Valve Heart Disease Patients with Atrial Fibrillation.

Int Heart J 2019 Jan 5;60(1):145-150. Epub 2018 Dec 5.

Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University.

The mechanism underlying thrombosis in atrial fibrillation (AF) is not yet clearly understood. The apelin/APJ axis parallel and counter-regulate with the angiotensin system. The present study hypothesizes that apelin/APJ axis exert its anti-thrombus effect in normal left atrial tissue and is disrupted by up-regulated renin-angiotensin-aldosterone system (RAAS) signaling during AF. Read More

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http://dx.doi.org/10.1536/ihj.18-166DOI Listing
January 2019
5 Reads
1.127 Impact Factor

Medical Castration is a Rare but Possible Trigger of Torsade de Pointes and Ventricular Fibrillation.

Int Heart J 2019 Jan 5;60(1):193-198. Epub 2018 Dec 5.

Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui.

Prostate cancer is the most common non-cutaneous malignancy in men and has been steadily rising in an aging society. Medical castration therapy is effective for metastatic prostate cancer, but the proarrhythmic properties have not been reported. We present a 71-year-old Japanese man with metastasis prostate cancer that, during medical castration therapy, had torsades de pointes (TdP) with a QT prolongation and ventricular fibrillation (VF). Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-127DOI Listing
January 2019
16 Reads

Characteristics, Mechanism and Long-Term Ablation Outcome of Atrial Tachycardias After Mitral Valvular Surgery and Concomitant Cox-MAZE IV Procedure.

Int Heart J 2019 Jan 5;60(1):71-77. Epub 2018 Dec 5.

Department of Cardiology, Atrial Fibrillation Center, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences.

The incidence of atrial tachycardia (AT) after rheumatic mitral valvular (RMV) surgery has been well described. However, there have been few reports on the characteristics, mechanism, and long-term ablation outcome of ATs after RMV surgery and concomitant Cox-MAZE IV procedure.The present study reviewed consecutive patients who underwent AT ablation between May 2008 and July 2013. Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-117DOI Listing
January 2019
18 Reads
1.127 Impact Factor

Pressure Overload Impairs Cardiac Function in Long-Chain Fatty Acid Transporter CD36-Knockout Mice.

Int Heart J 2019 Jan 5;60(1):159-167. Epub 2018 Dec 5.

Rinku General Medical Center.

CD36 is one of the important transporters of long-chain fatty acids (LCFAs) in the myocardium. We previously reported that CD36-deficient patients demonstrate a marked reduction of myocardial uptake of LCFA, while myocardial glucose uptake shows a compensatory increase, and are often accompanied by cardiomyopathy. However, the molecular mechanisms and functional role of CD36 in the myocardium remain unknown. Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-114DOI Listing
January 2019
18 Reads

A Modified Loop Snare Technique for Difficult Retrievals of Inferior Vena Cava Filter and Migrated Coil.

Int Heart J 2019 Jan 5;60(1):93-99. Epub 2018 Dec 5.

Department of Vascular Surgery, Qilu Hospital of Shandong University.

The aim of this study was to evaluate the safety and efficacy of a modified loop snare technique for retrieval of difficult inferior vena cava (IVC) filters and migrated coils.A retrospective review of Günther Tulip filter retrievals between January 2014 and February 2017 was performed. A total of 316 IVC filter retrievals were attempted. Read More

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http://dx.doi.org/10.1536/ihj.18-075DOI Listing
January 2019
4 Reads