148 results match your criteria International Seminars in Surgical Oncology ISSO [Journal]


Isolated skeletal muscle metastasis following successful treatment of laryngeal cancer: case report.

Int Semin Surg Oncol 2010 Feb 28;7(1). Epub 2010 Feb 28.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.

Skeletal muscle metastases from tumors are a rare occurrence and can present difficult management decisions. We report here on a patient that had been previously treated for squamous cell laryngeal cancer with surgical resection and adjuvant systemic chemotherapy that presented with a metastasis to the rectus abdominis muscle without evidence of recurrent disease at the primary site. After a metastatic workup with PET/CT scan suggested this to be an isolated lesion, surgical excision with negative margins was performed based upon limited treatment options secondary to the location of the tumor and his favorable prognosis suggested by his pathological staging at the time of the initial resection. Read More

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http://dx.doi.org/10.1186/1477-7800-7-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838919PMC
February 2010
10 Reads

An interesting diagnosis for a presacral mass: case report.

Int Semin Surg Oncol 2009 Nov 8;6:18. Epub 2009 Nov 8.

Department of Orthopaedics and Department of Surgery, University of Melbourne, St Vincent's Hospital, Melbourne, Australia.

A presacral mass can present a diagnostic dilemma for the surgical oncologist. Differential diagnoses include congenital causes such as teratoma or chordoma, neurological causes such as neurilemoma or neurofibroma or other malignancies such as lymphoma or sarcoma. Diagnosis usually requires imaging such as CT and MRI and tissue biopsy. Read More

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http://dx.doi.org/10.1186/1477-7800-6-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777176PMC
November 2009
7 Reads

c-KIT positive Gastrointestinal Stromal Tumor presenting with acute bleeding in a patient with neurofibromatosis type 1: a case report.

Int Semin Surg Oncol 2009 Oct 23;6:17. Epub 2009 Oct 23.

Imperial College Healthcare Trust, Hammersmith Hospital, Department of Hepatopancreatic and Biliary Surgery, Du Cane Road, London, W12 0HS, UK.

Background: Gastrointestinal stromal tumours are rare (GIST). However, the incidence of GIST among neurofibromatosis type 1 (NF-1) patients is approximately 3.9-25%. Read More

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http://dx.doi.org/10.1186/1477-7800-6-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776011PMC
October 2009
4 Reads

Surgical treatment of a giant tibial high-grade mixofibrosarcoma with preservation of limb function: a case report.

Int Semin Surg Oncol 2009 Sep 17;6:16. Epub 2009 Sep 17.

Department of Orthopaedic and Traumatology, Catholic University of Rome, Italy.

Myxofibrosarcoma is one of the most common sarcomas in elderly patients showing a slight male prevalence. The tumor is mainly located in lower and upper extremities and rarely in trunk, neck and feet. We present a case of a 84-year-old man referred to our tumour center with a giant and neglected high-grade tibial myxofibrosarcoma in the anteromedial side of tibial mid-diaphysis. Read More

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http://dx.doi.org/10.1186/1477-7800-6-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753323PMC
September 2009
8 Reads

Myoepithelioma within the carpal tunnel: a case report and review of the literature.

Int Semin Surg Oncol 2009 Sep 9;6:15. Epub 2009 Sep 9.

Department of Orthopaedics and Department of Surgery, University of Melbourne, St Vincent's Hospital, Melbourne, Australia.

Myoepitheliomas of the extremity are rare and usually benign, while a minority display malignant features. This case demonstrates the diagnosis and management of myoepithelioma within the carpal tunnel. Clinical and radiological tumour features were evaluated. Read More

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http://dx.doi.org/10.1186/1477-7800-6-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748076PMC
September 2009
4 Reads

Breast cancer incidence in Greek women in relation to ABO blood groups and Rh factor.

Int Semin Surg Oncol 2009 Aug 18;6:14. Epub 2009 Aug 18.

2nd Department of Propaedeutic Surgery, University of Athens, School of Medicine, LAIKO General Hospital, Athens, Greece.

Aim: To investigate the correlation between breast cancer in Greek women and ABO blood groups.

Material-methods: In 166 female patients with breast cancer factors such as blood group, histological type, family history, presence or absence of nodal and/or distant metastases were examined. These patients had similar demographic, clinical, surgical, immunohistochemical, laboratory, and follow-up data and this group is representative of general population of women in Greece. Read More

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http://dx.doi.org/10.1186/1477-7800-6-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741482PMC
August 2009
23 Reads

Hepatoid adenocarcinoma of the stomach - a different histology for not so different gastric adenocarcinoma: a case report.

Int Semin Surg Oncol 2009 Aug 12;6:13. Epub 2009 Aug 12.

Department of Medical Oncology, Hospital General Universitario de Elche, Elche, Alicante, Spain.

Hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphological similarities to hepatocellular carcinoma. Hepatoid adenocarcinoma of the stomach is a cancer with an extremely poor prognosis with few cases reported. Here, we describe a 75-year-old Spanish man referred to our hospital with a history of abdominal pain, general fatigue, anorexia and sickness. Read More

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http://dx.doi.org/10.1186/1477-7800-6-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731104PMC
August 2009
13 Reads

Breast clinic and life style study BLLISS.

Int Semin Surg Oncol 2009 Jun 30;6:12. Epub 2009 Jun 30.

Department of Surgery, Russell's Hall Hospital, Dudley, DY1 2HQ, UK.

Background: Independent, strong and unequivocal evidence suggests that life style factors such as obesity and lack of physical activity along with certain reproductive choices can increase the risk of breast cancer. There are no studies measuring the effectiveness of guidelines from the Department of Health regarding life style choices made by women presenting to breast clinics. The aim of this audit was to study the prevalence of obesity, physical activity and reproductive factors in women referred to breast clinic. Read More

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http://dx.doi.org/10.1186/1477-7800-6-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723121PMC
June 2009
3 Reads

Retraction: Male breast cancer: thirteen years experience of a single center.

Int Semin Surg Oncol 2009 04 17;6:11. Epub 2009 Apr 17.

Department of Surgery, University Hospital of Baskent, Ankara 06490, Turkey.

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http://dx.doi.org/10.1186/1477-7800-6-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679040PMC
April 2009
4 Reads

Primitive Neuroectodermal Tumour (PNET) in subcutaneous abdominal wall: a case report.

Int Semin Surg Oncol 2009 Mar 31;6:10. Epub 2009 Mar 31.

Department of Surgery, St Mary's Hospital, Isle of Wight NHS Trust, Parkhurst Road, Newport, Isle of Wight, PO30 5TG, UK.

Primitive neuroectodermal tumour (PNET) is a rare tumour mainly found in children under ten years old. It may be broadly categorised into those occurring from the central or peripheral nervous system of which the majority arise centrally. We report a 61 year-old lady who had previous lobular breast cancer presenting with a rapidly expanding lesion in her anterior right upper abdominal wall. Read More

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http://dx.doi.org/10.1186/1477-7800-6-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667515PMC
March 2009
4 Reads

Monophasic synovial sarcoma of the pharynx: a case report.

Int Semin Surg Oncol 2009 Mar 31;6. Epub 2009 Mar 31.

Department of Surgery, St Mary's Hospital, Isle of Wight NHS Trust, Parkhurst Road, Newport, Isle of Wight, PO30 5TG, UK.

Synovial sarcomas are a rare form of soft tissue sarcomas. We present a case of a 62 year-old male presenting with a left thyroid lump initially though to be a thyroid adenoma but subsequently diagnosed as a monophasic synovial sarcoma of the pharynx. We discuss the diagnosis and treatment of this case. Read More

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http://dx.doi.org/10.1186/1477-7800-6-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670314PMC
March 2009
5 Reads

Internal auditory canal metastasis mimicking a vestibular schwannoma at presentation - a case report and review of the literature.

Int Semin Surg Oncol 2009 Mar 31;6. Epub 2009 Mar 31.

Department of Oncology, Essex County Hospital, Lexden Road, Colchester, Essex CO3 3NB, UK.

Metastasis to the internal auditory canal from breast carcinoma is extremely rare and difficult to diagnose. It radiologically mimics vestibular schwannoma and can occur as a first manifestation of systemic relapse after a long disease-free interval in patients previously treated for early breast cancer. The diagnosis is usually made retrospectively and the optimal management of such metastasis following complete resection remains undefined. Read More

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http://dx.doi.org/10.1186/1477-7800-6-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670313PMC
March 2009
5 Reads

Successful pregnancy after breast cancer therapy: dream or reality?

Int Semin Surg Oncol 2009 Mar 2;6. Epub 2009 Mar 2.

2nd Department of Propedeutic Surgery, Medical School, University of Athens, Laiko General Hospital, Athens, Greece.

Background: Nowadays, more breast cancer patients want to have children after the diagnosis of cancer. The purpose of this study is to review the possibility and risks of giving birth among women with breast cancer previously treated by chemotherapy.

Case Presentation: Two young women aged 28 and 34 respectively, were treated in our clinic for breast cancer, the first (negative hormonal receptors) by surgery, chemotherapy and radiotherapy and the second (positive hormonal receptors) by surgery, radiotherapy and tamoxifen. Read More

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http://dx.doi.org/10.1186/1477-7800-6-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651905PMC
March 2009
8 Reads

Phylloides tumor of the breast: a rare neoplasm, though not that innocent.

Int Semin Surg Oncol 2009 Feb 20;6. Epub 2009 Feb 20.

Department of Propedeutic Surgery, Medical School, University of Athens, Laiko General Hospital, Athens, Greece.

Background: Cystosarcoma phylloides (CP) is an extremely rare form of breast cancer with an unpredictable clinical course. The histological characteristics of this neoplasm have not proved to offer much in the estimation of prognosis of these patients.

Patients And Methods: In our clinics, in a time period of 38 years, 22 patients with cystosarcoma phylloides were treated. Read More

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http://dx.doi.org/10.1186/1477-7800-6-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649148PMC
February 2009
6 Reads

Current indications for post-mastectomy radiation.

Int Semin Surg Oncol 2009 Feb 9;6. Epub 2009 Feb 9.

Academic Oncology Unit, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, Middlesex, HA6 2RN, UK.

It has been long established that post-mastectomy radiotherapy reduces the risk of locoregional failure. A survival advantage, however, has only recently been demonstrated. We here provide a review of the literature as regards to the current indications for post-mastectomy radiotherapy. Read More

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http://dx.doi.org/10.1186/1477-7800-6-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647547PMC
February 2009
4 Reads

Male breast cancer: thirteen years experience of a single center.

Int Semin Surg Oncol 2009 Feb 5;6. Epub 2009 Feb 5.

Department of Surgery, University Hospital of Baskent, Ankara 06490, Turkey.

Background: This retrospective study analysed the epidemiological, clinical, and therapeutic profiles of breast cancer in males.

Methods: We report our experience at the Hospital of the University of Baskent, where 20 cases of male breast cancer were observed and treated between 1995-2008.

Results: Median age at presentation was 66,7 +/- 10,9 years. Read More

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http://dx.doi.org/10.1186/1477-7800-6-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642849PMC
February 2009
4 Reads

Choroidal eye metastases from (recurrent) primary peritoneal carcinoma: case report and review of the literature.

Int Semin Surg Oncol 2009 Jan 20;6. Epub 2009 Jan 20.

Northern Gynaecological Oncology Centre, Gateshead Health NHS Trust, Queen Elizabeth Hospital, Sheriff Hill Gateshead NE9 6SX, UK.

Background: Choroidal metastases from gynaecological primary are extremely rare. There is no documented case in the literature of choroid metastasis in a patient with primary peritoneal carcinoma (PPC).

Methods & Results: We describe the first case of a 54-year-old woman with a history of borderline mucinous tumour who presented 17 months later with PPC and 21 months after with recurrent disease metastatic to the eye, and review pertinent literature. Read More

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https://issoonline.biomedcentral.com/articles/10.1186/1477-7
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http://dx.doi.org/10.1186/1477-7800-6-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633273PMC
January 2009
8 Reads

Maffucci syndrome and soft tissue sarcoma: a case report.

Int Semin Surg Oncol 2009 Jan 13;6. Epub 2009 Jan 13.

Department of Surgical Oncology, Hospital São José, Criciúma, Brazil.

Background: Maffucci syndrome, a congenital mesodermal dysplasia characterized by multiple enchondromas and hemangiomas, was first described in 1881, and 200 cases have been reported in the literature since then. Its etiology is unknown, there is no predilection for race or sex, and the development of lesions usually occurs in puberty. The risk of sarcomatous transformation is about 25%. Read More

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http://dx.doi.org/10.1186/1477-7800-6-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647940PMC
January 2009
28 Reads

Obesity in post menopausal women with a family history of breast cancer: prevalence and risk awareness.

Int Semin Surg Oncol 2009 Jan 8;6. Epub 2009 Jan 8.

Department of Surgery, Russells Hall Hospital, Dudley, West Midlands, DY1 2HQ, UK.

Background: Obesity and physical activity are modifiable risk factors in the development of post-menopausal breast cancer. The aim of this study was to assess the level of awareness and prevalence of these factors in women attending family history clinics.

Methods: Women attending the breast cancer family history clinic from 2004 to 2006 completed a questionnaire (SP15 format) about their knowledge of and exposure to various diet and lifestyle factors. Read More

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http://issoonline.biomedcentral.com/articles/10.1186/1477-78
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http://dx.doi.org/10.1186/1477-7800-6-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628939PMC
January 2009
6 Reads

Gamma probes and their use in tumor detection in colorectal cancer.

Int Semin Surg Oncol 2008 Nov 19;5:25. Epub 2008 Nov 19.

Division of Nuclear Medicine, Georgetown University Hospital, Washington DC, 20007, USA.

The purpose of this article is to summarize the role of gamma probes in intraoperative tumor detection in patients with colorectal cancer (CRC), as well as provide basic information about the physical and practical characteristics of the gamma probes, and the radiopharmaceuticals used in gamma probe tumor detection. In a significant portion of these studies, radiolabeled monoclonal antibodies (Mabs), particularly 125I labeled B72.3 Mab that binds to the TAG-72 antigen, have been used to target tumor. Read More

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http://dx.doi.org/10.1186/1477-7800-5-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596150PMC
November 2008
3 Reads

A pulmonary mass with invasion into the heart.

Int Semin Surg Oncol 2008 Oct 17;5:24. Epub 2008 Oct 17.

Department of Respiratory Medicine, St James Hospital, Dublin 8, Ireland.

We describe the case of a 58 year old woman who presented with bronchial atypical carcinoid found at surgery to invade the left atrium along the pulmonary veins. A right pneumonectomy and removal of a portion of the left atrium was performed. The patient made an excellent post operative recovery. Read More

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http://dx.doi.org/10.1186/1477-7800-5-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576302PMC
October 2008
7 Reads

The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer.

Int Semin Surg Oncol 2008 Oct 16;5:23. Epub 2008 Oct 16.

Metastasis research Group, University Department of Surgery, Cardiff University School of Medicine, Heath Park, Cardiff, CF4 4XN, UK.

Background: Development of metastasis in breast cancer is a multi-step process comprising changes in cytoskeletal structure and gene expression of tumour cells leading to changes in cell adhesion and motility. The Rho GTPase proteins, which function as guanine nucleotide regulated binary switches, govern a variety of cellular processes including cell motility and migration, changes in cell adhesion as well as actin cytoskeletal reorganisation and gene expression/transcription. One group of activators which regulate the Rho-GTPases is the guanine nucleotide exchange factors (GEFs), and this study looked at three such GEFs, Trio, Vav1 and TIAM-1. Read More

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http://dx.doi.org/10.1186/1477-7800-5-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576462PMC
October 2008
6 Reads

Adjacent thoracic lymph node metastases originating from two separate primary cancers: case report.

Int Semin Surg Oncol 2008 Oct 2;5:22. Epub 2008 Oct 2.

Department of Surgery, Watford General Hospital, Vicarage Rd, Watford, WD18 0HB, Hertfordshire, UK.

Reported is an unusual case of adjacent thoracic lymph nodes demonstrating metastases from two different primary malignancies. A 51 year-old woman with a previous history of bilateral breast cancer underwent a radical gastro-oesophagectomy for adenocarcinoma of the lower third of the oesophagus. The resection specimen demonstrated breast and oesophageal metastases in adjacent thoracic lymph nodes. Read More

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http://dx.doi.org/10.1186/1477-7800-5-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569954PMC
October 2008
7 Reads

Contribution of BRCA1 germline mutation in patients with sporadic breast cancer.

Int Semin Surg Oncol 2008 Aug 29;5:21. Epub 2008 Aug 29.

Cancer Genetics Lab; Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.

Hereditary artifacts in BRCA1 gene have a significant contributory role in familial cases of breast cancer. However, its germline mutational penetrance in sporadic breast cancer cases with respect to Pakistani population has not yet been very well defined. This study was designed to assess the contributory role of germline mutations of this gene in sporadic cases of breast cancer. Read More

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http://dx.doi.org/10.1186/1477-7800-5-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538523PMC
August 2008
4 Reads

Patient choice significantly affects mastectomy rates in the treatment of breast cancer.

Int Semin Surg Oncol 2008 Aug 11;5:20. Epub 2008 Aug 11.

The Breast Unit, University Hospital of North Staffordshire, Stoke on Trent, Staffordshire, ST4 6QG, UK.

Mastectomy rates may be affected by patient choice. 203 patients who had a Total Mastectomy for breast cancer were invited to complete questionnaires at routine follow up clinics to ascertain if they had been offered a choice of Breast Conserving Surgery (BCS), and to establish the reasons for their preference. Questionnaires were checked against medical and nursing records to confirm the reasons for the patients' choice of mastectomy. Read More

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http://dx.doi.org/10.1186/1477-7800-5-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518550PMC
August 2008
5 Reads

A case of gastrointestinal stromal tumor with spontaneous rupture in the greater omentum.

Int Semin Surg Oncol 2008 Jul 29;5:19. Epub 2008 Jul 29.

Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya, Aichi, 467-8601, Japan.

Background: Although GIST generally occurs in the digestive tract, such as the stomach, and small and small intestine primarily, Omental GIST tumours are very rare.

Case Presentation: A 63-year-old male patient, who recognized an abdominal tumor 1 year before admission, had a slight expansion of the tumor, reduction of the body and malaise, was consulted to our hospital. Abdominal CT and MRI revealed a cystic lesion of 26 cm in diameter with a clear boundary from immediately below the interseptum to the pelvic cavity, and imaged the septum and cystic wall. Read More

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http://dx.doi.org/10.1186/1477-7800-5-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515846PMC
July 2008
6 Reads

Early distant relapse after optimal local control in locally advanced rectal cancer.

Int Semin Surg Oncol 2008 Jul 14;5:18. Epub 2008 Jul 14.

Servicio de Oncología Médica, Hospital General Universitario de Elche, Elche, Alicante, Spain.

We present a case of locally advanced rectal cancer with initial optimal local control after neoadjuvant concurrent chemoradiotherapy followed by surgery; early liver recurrence then occurred and was treated again with curative intent with neoadjuvant combination chemotherapy followed by liver surgery. We reflect on this difficult problem and discuss relevant topics to this case report. Read More

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http://dx.doi.org/10.1186/1477-7800-5-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481251PMC
July 2008
6 Reads

Hemorrhage associated with hepatic artery pseudoaneurysms after regional chemotherapy with floxuridine: case report.

Int Semin Surg Oncol 2008 Jul 11;5:17. Epub 2008 Jul 11.

Department of Oncology, University Hospital Zurich, Zurich, Switzerland.

Pseudoaneurysms of the hepatic artery are a rare complication in patients with primary or secondary liver tumors treated with intra-arterial chemotherapy. We present two patients who developed this complication after placement of a catheter system into the gastroduodenal artery and initiation of regional chemotherapy with floxuridine. Diagnosis was made after symptomatic bleeding occurred, necessitating emergency angiography with coil embolization. Read More

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http://dx.doi.org/10.1186/1477-7800-5-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2478651PMC
July 2008
6 Reads

Women with large breasts are at an increased risk of advanced breast cancer.

Int Semin Surg Oncol 2008 Jun 30;5:16. Epub 2008 Jun 30.

Department of Surgery, Russells Hall Hospital, Dudley, UK.

Background: The risk of nodal metastasis is higher in women with bigger breast. It is not clear if this increase is due to the size of the breast (largely related to obesity) or is the result of larger tumour size at presentation (due to delayed diagnosis). It is hypothesised that women with large breasts are more likely to have node positive disease mainly attributable to their breast size. Read More

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http://dx.doi.org/10.1186/1477-7800-5-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474642PMC
June 2008
3 Reads

Uterine leiomyoma with tubules.

Int Semin Surg Oncol 2008 Jun 9;5:15. Epub 2008 Jun 9.

Institute of Anatomic Pathology, "S,Maria del Carmine" Hospital Rovereto, Rovereto (TN), Italy.

We report two cases of "uterine leiomyoma with tubules" as a new pathological entity. Since these are biphasic neoplasms (composed by epithelial and mesenchimal elements), the differential diagnosis is between mixed mullerian tumors and uterine tumors resembling ovarian sex cord tumors (UTROSCTs). In the differential diagnosis, the mixed mullerian tumors are easily excluded because of histological and immunohistochemical features. Read More

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http://dx.doi.org/10.1186/1477-7800-5-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2459196PMC
June 2008
4 Reads

Metastatic Hurthle Cell Carcinoma of the thyroid presenting as a Breast Lump: A Case Report.

Int Semin Surg Oncol 2008 May 27;5:14. Epub 2008 May 27.

The Breast Unit, Department of Surgery, Southend University Hospital, Prittlewell Chase, Westcliff-on-Sea, Essex SS0 0RY, UK.

Background: Hurthle cell carcinoma of the thyroid is a rare form of thyroid cancer. It may present as a low grade tumour or can present as a more aggressive metastatic carcinoma. Hurthle cell carcinoma has the highest incidence of metastasis among all differentiated thyroid cancers. Read More

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http://dx.doi.org/10.1186/1477-7800-5-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409361PMC
May 2008
5 Reads

The importance of margins status after breast conservative surgery and radiotherapy in node positive patients: a follow-up of 10-15 years.

Int Semin Surg Oncol 2008 May 22;5:13. Epub 2008 May 22.

Department of Surgery, Oxford Radcliffe NHS Trust, Oxford, UK.

Background: Margin status is the main factor determining local recurrence (LR) after wide excision and radiotherapy for breast cancer. The aim of the study is to evaluate if positive margins are as great a risk factor for LR in node-positive as in node-negative patients, since the major risk in the former group is dissemination and whether there is a correlation between nodal status and margins in relation to prognosis.

Methods: 773 patients underwent WLE and radiotherapy between 1988 and 1992 and were followed-up (> 10 years) to determine LR rates according to margin and nodal status. Read More

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http://dx.doi.org/10.1186/1477-7800-5-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409360PMC
May 2008
3 Reads

Mirizzi Syndrome: an unexpected problem of cholelithiasis. Our experience with 27 cases.

Int Semin Surg Oncol 2008 May 21;5:12. Epub 2008 May 21.

2nd Department of Propaedeutic Surgery, Medical School, University of Athens, Laiko General Hospital, Athens, Greece.

Purpose: Mirizzi syndrome is a rare complication of long standing cholelithiasis. The purpose of this study is to retrospectively estimate the diagnostic and treatment methods applied in patients with Mirizzi syndrome.

Materials And Methods: Our experience with 27 cases with Mirizzi syndrome is presented. Read More

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http://dx.doi.org/10.1186/1477-7800-5-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413250PMC
May 2008
5 Reads

Exophytic growth of a neglected giant subcutaneous Leiomyosarcoma of the lower extremity. A case report.

Int Semin Surg Oncol 2008 May 21;5:11. Epub 2008 May 21.

Orthopaedic Department, Catholic University of Rome, Italy.

Background: Superficial leiomyosarcoma is an exceedingly uncommon malignant tumor which could be located either to cutaneous or subcutaneous tissues. Increased mass size and depth, advanced tumor staging and inadequate surgical excision are the main prognostic factors for poor result.

Case Presentation: We report a rare case of a 71-year-old man with an extensive exophytic lesion (12 x 10 cm) in the anterior-medial side of the proximal right tibia. Read More

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http://issoonline.biomedcentral.com/articles/10.1186/1477-78
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http://dx.doi.org/10.1186/1477-7800-5-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409359PMC
May 2008
4 Reads

Intraosseous angiosarcoma with secondary aneurysmal bone cysts presenting as an elusive diagnostic challenge.

Int Semin Surg Oncol 2008 May 20;5:10. Epub 2008 May 20.

Department of Orthopaedics, St, Vincent's Hospital, Melbourne, Australia.

Angiosarcoma of bone is an exceedingly rare primary bone malignancy that can present as an aggressive osteolytic lesion. Histological diagnosis can be extremely challenging, as the pathological features often resemble that of aneurysmal bone cysts. We report an interesting and peculiar case of an intraosseous angiosarcoma that presented as a diagnostic dilemma and discuss the relevant radiological and pathologic findings. Read More

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http://issoonline.biomedcentral.com/articles/10.1186/1477-78
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http://dx.doi.org/10.1186/1477-7800-5-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413251PMC
May 2008
7 Reads

The role of Herceptin in early breast cancer.

Int Semin Surg Oncol 2008 Apr 28;5. Epub 2008 Apr 28.

St Georges Hospital, Blackshaw Road, Tooting, SW17 0QT, UK.

Herceptin is widely regarded as the most important development in the treatment of breast cancer since Tamoxifen and the development of the multidisciplinary team (MDT). It is particularly exciting from an oncological polint of view as it represents success in the emerging field of specific targeted therapies to specific molecular abnormalities in tumour cells. This review will focus on the nature of the Her2 overexpression and the role of herceptin in the treatment of early breast cancer. Read More

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http://dx.doi.org/10.1186/1477-7800-5-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2383915PMC
April 2008
4 Reads

Paraneoplastic cerebellar degeneration as a presentation of breast cancer - a case report and review of the literature.

Int Semin Surg Oncol 2008 Apr 21;5. Epub 2008 Apr 21.

Breast Surgery Unit, St George's Hospital NHS Trust, London, UK.

Paraneoplastic cerebellar degeneration is part of a rare spectrum of neurological syndromes whereby gynaecological, lung or breast cancers present primarily with neurological manifestations. The presence of onconeural antibodies and PET scanning help in the challenging diagnosis of these conditions but despite the treatment of the primary cancer, the prognosis for the neurological symptoms is poor. Read More

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http://dx.doi.org/10.1186/1477-7800-5-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373787PMC
April 2008
15 Reads

Uterine PEComa: appraisal of a controversial and increasingly reported mesenchymal neoplasm.

Authors:
Oluwole Fadare

Int Semin Surg Oncol 2008 Mar 6;5. Epub 2008 Mar 6.

Department of Pathology, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, TX 78236, USA.

In recent years, a group of tumors that have been designated "perivascular epithelioid cell tumors" (PEComa) have been reported with increasing frequency from a wide variety of anatomic locations. The uterus and retroperitoneum appear to be the most frequent sites of origin for these lesions. PEComas belong to an identically named family of tumors comprised of conventional angiomyolipomas, clear cell sugar tumors, lymphangiomyomatosis and clear cell myomelanocytic tumor of the falciform ligament/ligament teres, and are also known as PEComa-NOS. Read More

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http://dx.doi.org/10.1186/1477-7800-5-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278149PMC
March 2008
2 Reads

Surgical excision of an abdominal wall granular cell tumour with Permacol(R) mesh reconstruction: a case report.

Int Semin Surg Oncol 2008 Feb 25;5. Epub 2008 Feb 25.

Department of General Surgery, Blackpool Victoria Hospital, Blackpool Fylde and Wyre NHS Trust, Blackpool, FY2 8NR, UK.

Introduction: Granular cell tumours of the abdominal wall are extremely rare: less than 10 have been reported in the worldwide medical literature. We report this interesting case, review the relevant literature on this tumour and discuss surgical abdominal wall reconstruction options.

Case Presentation: A 70 year old lady presented with a left abdominal mass. Read More

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http://dx.doi.org/10.1186/1477-7800-5-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267469PMC
February 2008
2 Reads

A case of unilateral keloid after bilateral breast reduction.

Int Semin Surg Oncol 2008 Feb 24;5. Epub 2008 Feb 24.

St George's Hospital, Blackshaw Road, London, SW17 0QT, UK.

Keloid scar is a manifestation of abnormal wound healing in predisposed individuals. Many treatment modalities have been tried with varying degrees of success. Radiotherapy is one such modality that is widely recognised. Read More

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http://dx.doi.org/10.1186/1477-7800-5-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267204PMC
February 2008
4 Reads

Obesity and HER 2 overexpression: a common factor for poor prognosis of breast cancer.

Int Semin Surg Oncol 2008 Feb 24;5. Epub 2008 Feb 24.

Department of Surgery, Russells Hall Hospital, Dudley, West Midlands, DY1 2HQ, UK.

Background: Both obesity and over-expression of HER II are associated with poor prognosis of breast cancer. In vitro experiments suggest that anti-tumour activity of the anti-obesity drug Orlistat is likely to be due to transcriptional suppression of HER II expression. The overexpression of HER II is also positively correlated with other markers of prognosis of breast cancer such as cathepsin expression. Read More

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http://dx.doi.org/10.1186/1477-7800-5-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266765PMC
February 2008
3 Reads

Reconstruction after external hemipelvectomy using tibia-hindfoot rotationplasty with calcaneo-sacral fixation.

Int Semin Surg Oncol 2008 Jan 21;5. Epub 2008 Jan 21.

Department of Orthopaedic Surgery, St, Vincent's Hospital, Melbourne, Australia.

Background: External hemipelvectomy is associated with high post operative morbidity and a poor functional outcome. We aim to explore a reconstruction technique to improve function and post operative appearance for patients who undergo external hemipelvectomy.

Case Presentation: We present a Case where extensive cancer involvement of pelvis and femur was managed with a novel surgical technique, which involved a calf sparing modified anterior flap hemipelvectomy combined with rotationplasty of the spared calf and fixation of calcaneus to the sacrum, thereby recreating a new thigh stump. Read More

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http://issoonline.biomedcentral.com/articles/10.1186/1477-78
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http://dx.doi.org/10.1186/1477-7800-5-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2257950PMC
January 2008
5 Reads

Three stage axillary lymphatic massage optimizes sentinel lymph node localisation using blue dye.

Int Semin Surg Oncol 2007 Dec 22;4:30. Epub 2007 Dec 22.

Breast Unit, University Hospital of North Staffordshire, Keele University, Stoke-on-Trent, UK.

Aims: This paper describes a simple technique of axillary and breast massage which improves the successful identification of blue sentinel nodes using patent blue dye alone.

Methods: Patent blue dye was injected in the subdermal part of the retroaroelar area in 167 patients having surgical treatment for invasive breast cancer. Three stage axillary lymphatic massage was performed prior to making the axillary incision for sentinel lymph node biopsy. Read More

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http://dx.doi.org/10.1186/1477-7800-4-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248582PMC
December 2007
4 Reads

An oncoplastic technique to reduce the formation of lateral 'dog-ears' after mastectomy.

Int Semin Surg Oncol 2007 Dec 17;4:29. Epub 2007 Dec 17.

St George's Hospital, Blackshaw Road, London, UK.

Background: Lateral skin folds or 'dog-ears' are frequent following mastectomy, particularly in patients with large body habitus.

Methods: We describe a method of modifying the mastectomy incision and suturing to eliminate these lateral 'dog-ears'.

Conclusion: This surgical technique, as compared to others described in the literature, is simple, does not require additional incisions and is cosmetically acceptable to the patient. Read More

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http://dx.doi.org/10.1186/1477-7800-4-29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2231377PMC
December 2007
4 Reads

Splenic peliosis - a potentially fatal condition which can mimick malignancy.

Int Semin Surg Oncol 2007 Dec 8;4:27. Epub 2007 Dec 8.

Department of General Surgery, North Middlesex University Hospital, Sterling Way, Edmonton, London, UK.

Isolated splenic peliosis is an extremely rare occurrence, and this disease often manifests itself with spontaneous haemoperitoneum.We report a case where an otherwise healthy patient was found to have splenomegaly on clinical examination. On computerised tomography, a diagnosis of splenic malignancy was made, and the patient underwent a splenectomy. Read More

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http://dx.doi.org/10.1186/1477-7800-4-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222050PMC
December 2007
4 Reads

Is an aggressive surgical approach worthwhile in biliary cancer?

Int Semin Surg Oncol 2007 Oct 23;4:26. Epub 2007 Oct 23.

Department of Oncology, University Hospital, Raemistrasse 100, 8091 Zürich, Switzerland.

Background: Biliary cancer includes cancer of the gallbladder as well as extrahepatic and intrahepatic cholangiocarcinoma. Surgery is the only curative treatment option available. Recently, much more aggressive surgical approaches have been employed. Read More

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http://dx.doi.org/10.1186/1477-7800-4-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211286PMC
October 2007
5 Reads

Epithelial-myoepithelial carcinoma of the parotid gland, unusual malignancy radiologically simulating a benign lesion: case report.

Int Semin Surg Oncol 2007 Oct 16;4:25. Epub 2007 Oct 16.

Department of Pathology, National Institute for Infectious Diseases "L, Spallanzani" IRCCS, Rome, Italy.

Background: Ultrasound (US), Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are widely used in the clinical diagnosis of parotid gland tumors and their efficacy in identifying benign lesions is well documented. However, problems arise when facing some malignant lesions. Only few cases of salivary gland low grade malignant tumors have been previously reported in the literature complete with the radiological features. Read More

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http://dx.doi.org/10.1186/1477-7800-4-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2092427PMC
October 2007
7 Reads

Neoadjuvant chemotherapy for carcinoma of the oesophagus and oesophago-gastric junction: a six-year experience.

Int Semin Surg Oncol 2007 Oct 16;4:24. Epub 2007 Oct 16.

Department of Surgery, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, UK.

Background: Oesophageal cancer is a major clinical problem with a generally poor prognosis. As a result there has been interest in combining surgery with neoadjuvant chemotherapy to try and improve outcomes, although the current evidence for benefit is inconsistent. We aimed to compare, in a non-randomised study, the post-operative complication rate and short and long-term survival of patients who underwent surgical resection for carcinoma of the oesophagus and types I and II carcinoma of the oesophago-gastric junction with or without neo-adjuvant chemotherapy. Read More

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http://dx.doi.org/10.1186/1477-7800-4-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117002PMC
October 2007
11 Reads

Preoperative bi-fractionated accelerated radiation therapy for combined treatment of locally advanced rectal cancer in a consectutive series of unselected patients.

Int Semin Surg Oncol 2007 Sep 20;4:23. Epub 2007 Sep 20.

Dept. of Radiotherapy-European Institute of Oncology and University of Milano, Via Ripamonti, 435, Italy.

Background: although preoperative RT (Radiation Therapy) is becoming the preferred approach for combined treatment of locally advanced rectal adenocarcinoma, no regimen can be now considered as a standard. Since the toxicity of preoperative RT isn't yet completely known, and the advantages of preoperative RT could be counterbalanced by increased postoperative morbidity and mortality, a monocentre series of preoperative bifractionated accelerated RT was retrospectively reviewed to clarify toxicity and outcomes after a prolonged follow up.

Methods: patients were screened following these eligibility criteria: histology-proven adenocarcinoma of the rectum; distal tumour extent at 12 cm or less from the anal verge; clinical stage T3-4/anyN, or anyT/N1-2; ECOG Performance Status 0-2. Read More

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http://dx.doi.org/10.1186/1477-7800-4-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063497PMC
September 2007
3 Reads

Quantification of angiogenesis in estrogen receptor-positive and negative breast carcinoma.

Int Semin Surg Oncol 2007 Aug 24;4:22. Epub 2007 Aug 24.

Department of Gynecology, Federal University of Piauí, Teresina, Piauí, Brazil.

Background: The objective of this study was to evaluate angiogenesis according to CD34 antigen expression in estrogen receptor (ER)-positive and negative breast carcinomas.

Methods: This study comprised 64 cases of infiltrating ductal carcinoma in postmenopausal women divided into two groups: Group A: ER-positive, n = 35; and Group B: ER-negative, n = 29. The anti-CD34 monoclonal antibody was used as a marker for endothelial cells. Read More

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http://issoonline.biomedcentral.com/articles/10.1186/1477-78
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http://dx.doi.org/10.1186/1477-7800-4-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008197PMC
August 2007
5 Reads