974 results match your criteria International Reviews of Immunology [Journal]


Single-Domain Antibodies or Nanobodies: A Class of Next-Generation Antibodies.

Int Rev Immunol 2019 Feb 11:1-7. Epub 2019 Feb 11.

b Venom & Biotherapeutics Molecules Lab., Biotechnology Research Center, Pasteur Institute of Iran , Tehran , Iran.

Nanobodies for the first time were identified in the sera of Camelidae. Single-domain antibodies or nanobodies are a class of next-generation antibodies that have specific features: small size (in nanoscale), high penetration in various tissues, high stability in hard situations and ease production process in microbial systems. In fact single-domain antibodies are the smallest fragment of the antibody with binding ability. Read More

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http://dx.doi.org/10.1080/08830185.2018.1526932DOI Listing
February 2019

Current Trend in Immunotherapy for Peanut Allergy.

Int Rev Immunol 2019 Jan 13:1-12. Epub 2019 Jan 13.

a Department of Biotechnology, Faculty of Applied Sciences , UCSI University , Cheras , Kuala Lumpur , Malaysia.

Peanut allergy is a hypersensitivity reaction with symptoms varying from mild to severe anaphylaxis, tends to be lifelong and very few are able to outgrow this allergy. The prevalence of peanut allergy is highest among the Western countries and over the past decade, a 3.5 fold increase in prevalence of peanut allergy was reported among children in the United States. Read More

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https://www.tandfonline.com/doi/full/10.1080/08830185.2018.1
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http://dx.doi.org/10.1080/08830185.2018.1509967DOI Listing
January 2019
4 Reads

Blood coagulation: a powerful bactericidal mechanism of human innate immunity.

Int Rev Immunol 2019 Jan 11:1-15. Epub 2019 Jan 11.

b Hospital Longlern , Gottingen , Germany.

Infection proliferates and disseminates rapidly and so innate immunity should react effectively and fast. Innate immunity mechanisms depend upon fluid dynamics and are different in compartments with slow (the tissues) and rapid (the bloodstream) liquid flow. In the tissues, coagulation initiated by clotting factors, platelets and erythrocytes, is prompt and effective mechanism of the first line of antibacterial defense. Read More

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http://dx.doi.org/10.1080/08830185.2018.1533009DOI Listing
January 2019
2 Reads

An update on the cutaneous manifestations of coeliac disease and non-coeliac gluten sensitivity.

Int Rev Immunol 2018 Dec 5:1-10. Epub 2018 Dec 5.

b Institute of Food Sciences, CNR , Avellino , Italy.

Introduction: Coeliac disease is a gluten-induced immune-mediated enteropathy, characterised by the expression of specific genotypes and the production of autoantibodies. The inflammatory process specifically targets the intestinal mucosa, but gastrointestinal and extraintestinal signs and symptoms can also be present. Non-coeliac gluten sensitivity (NCGS) can be diagnosed in individuals who have intestinal and/or extraintestinal symptoms related to the ingestion of gluten, but do not have autoantibodies and do not suffer from lesions in the duodenal mucosa. Read More

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https://www.tandfonline.com/doi/full/10.1080/08830185.2018.1
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http://dx.doi.org/10.1080/08830185.2018.1533008DOI Listing
December 2018
17 Reads

Many Ways-One Destination: Different Types of Neutrophils Death.

Int Rev Immunol 2018 Dec 5:1-15. Epub 2018 Dec 5.

a Department of Immunology , Medical University of Bialystok , Bialystok , Poland.

Neutrophils constitute the most numerous populations of peripheral blood leukocytes, fulfilling the fundamental role in the development of the innate immune response. As the cells of the first line of defense, they guard the organism against the spread of pathogenic microorganisms. Neutrophils, similar to the other cells of the immune system, enter the path of death after fulfilling their biological function. Read More

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https://www.tandfonline.com/doi/full/10.1080/08830185.2018.1
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http://dx.doi.org/10.1080/08830185.2018.1540616DOI Listing
December 2018
9 Reads

Donor-specific anti-HLA antibodies by solid phase immunoassays: advantages and technical concerns.

Int Rev Immunol 2018 Nov 20:1-11. Epub 2018 Nov 20.

a Department of Clinical Immunology , Aarhus University Hospital , Aarhus , Denmark.

The detection of donor-specific antibodies (DSAs) is a cornerstone in the immunological risk assessment prior to organ transplantation. The detection methods have developed rapidly during the last decade, and the evidence for clinical interpretation of results obtained by solid phase immunoassays (SPI) is slowly accumulating. Nevertheless, technical limitations and theoretical concerns still mean that "expert opinions" govern clinical decision-making when results of bead-based arrays are applied in immunological risk assessment prior to transplantation. Read More

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http://dx.doi.org/10.1080/08830185.2018.1525367DOI Listing
November 2018
1 Read

Psoriasis and cardiovascular disease: the elusive link.

Int Rev Immunol 2018 Nov 20:1-22. Epub 2018 Nov 20.

d Third Department of Cardiology , Athens University School of Medicine , Athens , Greece.

Psoriasis, an autoimmune inflammatory disease, with its most common coexisting condition, psoriatic arthritis, seem to be more than just a local skin or joint disease, as evidence has accumulated over the years that it is associated with cardiovascular disease (CVD), which may confer an increased cardiovascular event and death rate. The data come mostly from observational studies and meta-analyses and indicate a potential pathogenetic link between these two systemic diseases, however definite proof of this detrimental relationship awaits further prospective studies. Newer anti-psoriatic biologic therapies seem to confer a cardiovascular benefit, but this needs future randomized controlled studies to confirm. Read More

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https://www.tandfonline.com/doi/full/10.1080/08830185.2018.1
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http://dx.doi.org/10.1080/08830185.2018.1539084DOI Listing
November 2018
10 Reads

Evolution of innate immune sensors and responses during immune disorders and immunization against microbial infection.

Authors:
Himanshu Kumar

Int Rev Immunol 2018 11;37(5):215-216. Epub 2018 Nov 11.

a Editor in Chief, International Reviews of Immunology & Laboratory of Immunology and Infectious Disease Biology , Indian Institute of Science Education and Research (IISER) , Bhopal , India.

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http://dx.doi.org/10.1080/08830185.2018.1531195DOI Listing
November 2018
1 Read

How far have we reached in development of effective influenza vaccine?

Int Rev Immunol 2018 25;37(5):266-276. Epub 2018 Sep 25.

c Department of Chemical and Environmental Engineering, Faculty of Engineering , University of Nottingham Malaysia Campus , Jalan Braga , Semenyih, Selangor Darul Ehsan , Malaysia.

Despite of ongoing research programs and numerous clinical trials, seasonal influenza epidemics remain a major concern globally. Vaccination remains the most effective method to prevent influenza infection. However, current flu vaccines have several limitations, including limited vaccine capacity, long production times, inconsistence efficacy in certain populations, and lack of a "universal" solution. Read More

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http://dx.doi.org/10.1080/08830185.2018.1500570DOI Listing
September 2018

In this issue: Antibodies and T Cell subtypes in diseases and therapy.

Int Rev Immunol 2018 ;37(4):175-176

b International Reviews of Immunology, Translational Sciences , Kite Pharma Inc. , Santa Monica , CA , USA.

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https://www.tandfonline.com/doi/full/10.1080/08830185.2018.1
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http://dx.doi.org/10.1080/08830185.2018.1499488DOI Listing
January 2018
8 Reads

Evolution and species-specific conservation of toll-like receptors in terrestrial vertebrates.

Int Rev Immunol 2018 12;37(5):217-228. Epub 2018 Sep 12.

a Department of Genomics and Genetic Engineering, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO) , Karaj , Iran.

Toll-like receptors (TLRs) are known for their essential roles in promotion of innate immunity and induction of adaptive immunity through recognition of pathogen-associated molecular patterns (PAMPs) or danger associated molecular patterns (DAMPs). TLR genes are excellent models for the study of the selective pressure enforced by microorganisms on the host genome. Phylogenetic analyses have shown that interactions between pathogens and immune systems have changed during evolution. Read More

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https://www.tandfonline.com/doi/full/10.1080/08830185.2018.1
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http://dx.doi.org/10.1080/08830185.2018.1506780DOI Listing
September 2018
4 Reads

Antithymocytes globulins: Time to revisit its use in kidney transplantation?

Int Rev Immunol 2018 6;37(4):183-191. Epub 2018 Aug 6.

a Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, Interactions hôte-greffon-tumeur, Federation hospitalo-universitaire INCREASE, LabEX LipSTIC , Besançon , France.

T cell depletion by polyclonal antithymocyte globulins (ATG) has been used for many years in both organ and hematopoietic cell transplantation as an induction and rejection therapy. Nevertheless, its use remains largely empirical and many clinical questions, such as the determination of an individualized dose, therapeutic relevance of nondepletive effects, or prediction of long-term effects, are still unresolved. This review evaluates the evidence-based knowledge and the uncertainties concerning ATG, and suggests perspectives and opportunities for modern use of this old drug. Read More

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http://dx.doi.org/10.1080/08830185.2018.1455194DOI Listing
August 2018
2 Reads

IRF5-mediated immune responses and its implications in immunological disorders.

Int Rev Immunol 2018 9;37(5):229-248. Epub 2018 Jul 9.

b Department of Biomedical Sciences, Faculty of Science , The University of Nottingham Malaysia Campus , Selangor Darul , Ehsan , Malaysia.

Transcription factors are gene regulators that activate or repress target genes. One family of the transcription factors that have been extensively studied for their crucial role in regulating gene network in the immune system is the interferon regulatory factors (IRFs). IRFs possess a novel turn-helix turn motif that recognizes a specific DNA consensus found in the promoters of many genes that are involved in immune responses. Read More

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http://dx.doi.org/10.1080/08830185.2018.1469629DOI Listing
July 2018
2 Reads

Developing effective vaccines: Cues from natural infection.

Int Rev Immunol 2018 21;37(5):249-265. Epub 2018 Jun 21.

a Institute of Science , Nirma University , Ahmedabad , Gujarat , India.

The ultimate goal of any vaccine is to generate a heterogeneous and stable pool of memory lymphocytes. Vaccine are designed with the hope to generate antigen specific long-lived T cell responses, as it may be the case in natural infection; however, inducing such response by sub-unit vaccine has been a challenge. Although significant progress has been made, there is lot of scope for designing novel vaccine strategies by taking cues from the natural infection. Read More

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http://dx.doi.org/10.1080/08830185.2018.1471479DOI Listing

Challenges related to the immunogenicity of parenteral recombinant proteins: Underlying mechanisms and new approaches to overcome it.

Int Rev Immunol 2018 May 31:1-15. Epub 2018 May 31.

a Immunology Research Center , Iran University of Medical Sciences (IUMS) , Tehran , Iran.

Immune response elicited by therapeutic proteins is an important safety and efficacy issue for regulatory agencies, drug manufacturers, clinicians, and patients. Administration of therapeutic proteins can potentially induce the production of anti-drug antibodies or cell-mediated immune responses. At first, it was speculated that the immunogenicity is related to the non-human origin of these proteins. Read More

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http://dx.doi.org/10.1080/08830185.2018.1471139DOI Listing

Regulatory T-cell dynamics with abatacept treatment in rheumatoid arthritis.

Int Rev Immunol 2018 14;37(4):206-214. Epub 2018 May 14.

b College of Public Health, Medicine and Veterinary Sciences , James Cook University , Douglas , Townsville , Australia.

The progressive damage in rheumatoid arthritis (RA) has been linked to an increase in inflammatory Th1/Th17 cells and a decrease in number or function of immunomodulatory regulatory T cells (Tregs). Many therapies that are effective in RA are shown to affect Th1/Th17 cells and/or Tregs. One such therapy, abatacept, utilizes a physiologic immunomodulatory molecule called cytotoxic lymphocyte antigen-4 (CTLA-4) which causes contact-dependent inhibition of inflammatory T-cell activation. Read More

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http://dx.doi.org/10.1080/08830185.2018.1465943DOI Listing

In this issue: Role of immune cells and molecules in rheumatoid arthritis pathogenesis and cancer immunotherapy.

Int Rev Immunol 2018 05;37(3):127-128

b International Reviews of Immunology and Vice President, Translational Sciences , Kite Pharma Inc. , Santa Monica , CA , USA.

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http://dx.doi.org/10.1080/08830185.2018.1469353DOI Listing
May 2018
4 Reads

Th9 Cells: Probable players in ulcerative colitis pathogenesis.

Int Rev Immunol 2018 19;37(4):192-205. Epub 2018 Apr 19.

a Department of Microbiology and Immunology , Faculty of Medicine, Shahrekord University of Medical Sciences , Shahrekord , Iran.

T lymphocytes represent an important part of adaptive immune system undertaking different functions to regulate immune responses. CD4+ T cells are the most important activator cells in inflammatory conditions. Depending on the type of induced cells and inflamed sites, expression and activity of different subtypes of helper T cells are changed. Read More

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http://dx.doi.org/10.1080/08830185.2018.1457659DOI Listing
April 2018
4 Reads
4.100 Impact Factor

Chorea revealing systemic lupus erythematosus in a 13-year old boy: A case report and short review of the literature.

Int Rev Immunol 2018 29;37(4):177-182. Epub 2018 Mar 29.

a Department of Paediatrics , Venizeleion General Hospital , Heraklion, Crete , Greece.

Among the neurological manifestations of systemic lupus erythematosus (SLE), chorea is rare, presenting in less than 7% of the pediatric SLE patients. It can appear early in the onset of SLE, be the first or even the sole clinical feature of the illness and has strongly been associated with the presence of antiphospholipid antibodies. We report on the case of a 13-year old boy, admitted with acute onset chorea and finally diagnosed with SLE. Read More

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http://dx.doi.org/10.1080/08830185.2018.1452920DOI Listing
March 2018
2 Reads

In this issue: Effect of gut microbiome on mucosal immunity and enteric diseases.

Int Rev Immunol 2018 03;37(2):77-78

b Editor in Chief, International Reviews of Immunology and Vice President , Translational Sciences, Kite Pharma Inc. , Santa Monica , CA , USA.

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http://dx.doi.org/10.1080/08830185.2018.1450947DOI Listing
March 2018
3 Reads

Microbiota regulate the development and function of the immune cells.

Int Rev Immunol 2018 03 9;37(2):79-89. Epub 2018 Feb 9.

a Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education , Institute of Cell Biology, College of Life Sciences, Beijing Normal University , Beijing , China.

Microbiota is a group of microbes coexisting and co-evolving with the immune system in the host body for millions of years. There are mutual interaction between microbiota and the immune system. Immune cells can shape the populations of microbiota in the gut of animals and humans, and the presence of microbiota and the microbial products can regulate the development and function of the immune cells in the host. Read More

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http://dx.doi.org/10.1080/08830185.2018.1429428DOI Listing
March 2018
4 Reads

In this issue: Role of specific and non-specific immunity in disease.

Int Rev Immunol 2018 01;37(1):1-2

b Editor in Chief, International Reviews of Immunology and Vice President, Translational Sciences, Kite Pharma Inc. , Santa Monica , CA , USA.

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http://dx.doi.org/10.1080/08830185.2018.1432192DOI Listing
January 2018
5 Reads

The promising role of monoclonal antibodies for immunotherapy of the HIV-associated cancer, non-Hodgkin lymphoma.

Int Rev Immunol 2018 05 19;37(3):165-173. Epub 2017 Dec 19.

c Research Center for Immunodeficiencies , Children's Medical Center, Tehran University of Medical Sciences , Tehran , Iran.

Association between HIV/AIDS and some of the cancers such as lymphomais is well known. Relative risk for developing non-Hodgkin lymphoma (NHL) increases 60-200 folds in HIV-infected individuals. Diffuse large B cell lymphoma (DLBCL), primary effusion lymphoma (PEL), Burkitt's lymphoma (BL) and Plasmablastic Lymphoma (PBL) are among the most frequent subtypes. Read More

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http://dx.doi.org/10.1080/08830185.2017.1405396DOI Listing
May 2018
10 Reads
4.100 Impact Factor

The prognostic value of regulatory T cells infiltration in HER2-enriched breast cancer microenvironment.

Int Rev Immunol 2018 05 19;37(3):144-150. Epub 2017 Dec 19.

a Laboratory of Study and Application of DNA Polymorphisms and Immunology, Department of Pathological Sciences , Biological Sciences Center, State University of Londrina, Pr 445 Km 380 Celso Garcia Cid Highway , Londrina , Paraná , Brazil.

Breast cancer represents a complex and heterogeneous disease that comprises distinct disease conditions, histological features, and clinical outcome. Since many years, it has been demonstrated as an association between HER2 amplification and poor prognosis, because its overexpression is associated with an aggressive phenotype of breast tumor cells. A significant proportion of cases have developed resistance to the current therapies available. Read More

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http://dx.doi.org/10.1080/08830185.2017.1401620DOI Listing
May 2018
8 Reads

High-Altitude-Induced alterations in Gut-Immune Axis: A review.

Int Rev Immunol 2018 03 12;37(2):119-126. Epub 2017 Dec 12.

a Immunomodulation Division , Defence Institute of Physiology and Allied Sciences (DIPAS), DRDO , Delhi , India.

High-altitude sojourn above 8000 ft is increasing day by day either for pilgrimage, mountaineering, holidaying or for strategic reasons. In India, soldiers are deployed to these high mountains for their duty or pilgrims visit to the holy places, which are located at very high altitude. A large population also resides permanently in high altitude regions. Read More

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http://dx.doi.org/10.1080/08830185.2017.1407763DOI Listing
March 2018
6 Reads

Viral subversion of APOBEC3s: Lessons for anti-tumor immunity and tumor immunotherapy.

Int Rev Immunol 2018 05 6;37(3):151-164. Epub 2017 Dec 6.

a Program in Immunology and Infectious Diseases, Division of Biomedical Sciences, Faculty of Medicine , Memorial University of Newfoundland , St. John's, Newfoundland A1B 3V6 , Canada.

APOBEC3s (A3) are endogenous DNA-editing enzymes that are expressed in immune cells including T lymphocytes. A3s target and mutate the genomes of retroviruses that infect immune tissues such as the human immunodeficiency virus (HIV). Therefore, A3s were classically defined as host anti-viral innate immune factors. Read More

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https://www.tandfonline.com/doi/full/10.1080/08830185.2017.1
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http://dx.doi.org/10.1080/08830185.2017.1403596DOI Listing
May 2018
9 Reads

TLRs/NLRs: Shaping the landscape of host immunity.

Int Rev Immunol 2018 01 1;37(1):3-19. Epub 2017 Dec 1.

a Laboratory of Molecular Cell Biology, Centre for DNA Fingerprinting and Diagnostics (CDFD) , Tuljaguda Complex, Nampally, Hyderabad , India.

Innate immune system provides the first line of defense against pathogenic organisms. It has a varied and large collection of molecules known as pattern recognition receptors (PRRs) which can tackle the pathogens promptly and effectively. Toll-like receptors (TLRs) and NOD-like receptors (NLRs) are members of the PRR family that recognize pathogen associated molecular patterns (PAMPs) and play pivotal roles to mediate defense against infections from bacteria, fungi, virus and various other pathogens. Read More

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http://dx.doi.org/10.1080/08830185.2017.1397656DOI Listing
January 2018
9 Reads

Application of camelid heavy-chain variable domains (VHHs) in prevention and treatment of bacterial and viral infections.

Int Rev Immunol 2018 01 28;37(1):69-76. Epub 2017 Nov 28.

a School of Pharmacy and Life Sciences , Robert Gordon University , Garthdee Road, Aberdeen , United Kingdom.

Camelid heavy-chain variable domains (VHHs) are the smallest, intact, antigen-binding units to occur in nature. VHHs possess high degrees of solubility and robustness enabling generation of multivalent constructs with increased avidity - characteristics that mark their superiority to other antibody fragments and monoclonal antibodies. Capable of effectively binding to molecular targets inaccessible to classical immunotherapeutic agents and easily produced in microbial culture, VHHs are considered promising tools for pharmaceutical biotechnology. Read More

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http://dx.doi.org/10.1080/08830185.2017.1397657DOI Listing
January 2018
5 Reads

In this issue: Cancer immunity and immunotherapy.

Int Rev Immunol 2017 11;36(6):313-314

b Editor in Chief, International Reviews of Immunology and Vice President , Translational Sciences, Kite Pharma Inc. , Santa Monica , CA , USA.

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http://dx.doi.org/10.1080/08830185.2017.1398539DOI Listing
November 2017
4 Reads

In this issue: Fine tuners of immunity and their role in infectious and non-infectious diseases.

Int Rev Immunol 2017 09;36(5):257-258

b Editor in Chief, International Reviews of Immunology and Vice President, Translational Sciences , Kite Pharma Inc. , Santa Monica , CA , USA.

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http://dx.doi.org/10.1080/08830185.2017.1399712DOI Listing
September 2017
3 Reads

Role of MAIT cells in the immunopathogenesis of inflammatory diseases: New players in old game.

Int Rev Immunol 2018 03 6;37(2):90-110. Epub 2017 Nov 6.

b Laboratory of Innate Immunity, CHU Ste-Justine/Department of Microbiology , Infectious Diseases & Immunology, University of Montreal , Montreal , Quebec , Canada.

Current advances in immunology have led to the identification of a population of novel innate immune T cells, called mucosa-associated invariant T (MAIT) cells. The cells in humans express an invariant TCRα chain (Vα7.2-Jα33) paired with a limited subset of TCRβ chains (Vβ2, 13 and 22), are restricted by the MHC class I (MH1)-related (MR)-1, and recognize molecules that are produced in the bacterial riboflavin (vitamin B2) biosynthetic pathway. Read More

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http://dx.doi.org/10.1080/08830185.2017.1380199DOI Listing
March 2018
8 Reads
4.100 Impact Factor

Toll-like receptors: Significance, ligands, signaling pathways, and functions in mammals.

Int Rev Immunol 2018 01 13;37(1):20-36. Epub 2017 Oct 13.

b Animal Physiology Division , ICAR-National Institute of Animal Nutrition and Physiology , Adugodi, Bangalore , Karnataka , India.

This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling immune functions with emphasis on their significance, function, regulation and expression patterns. The tripartite TLRs are type I integral transmembrane receptors that are involved in recognition and conveying of pathogens to the immune system. These paralogs are located on cell surfaces or within endosomes. Read More

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http://dx.doi.org/10.1080/08830185.2017.1380200DOI Listing
January 2018
4 Reads

Analysis of host-pathogen modulators of autophagy during Mycobacterium Tuberculosis infection and therapeutic repercussions.

Int Rev Immunol 2017 09 4;36(5):271-286. Epub 2017 Oct 4.

a Department of Pathology and Laboratory Medicine, McGovern Medical School , University of Texas Health Sciences Center-Houston , Houston TX.

Mycobacterium tuberculosis is one of the most deadly human pathogens known today in modern world, responsible for about 1.5 million deaths annually. Development of TB disease occurs only in 1 out of 10 individuals exposed to the pathogen which indicates that the competent host defense mechanisms exist in majority of the hosts to control the infection. Read More

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http://dx.doi.org/10.1080/08830185.2017.1356924DOI Listing
September 2017
12 Reads

Focused ultrasound for immuno-adjuvant treatment of pancreatic cancer: An emerging clinical paradigm in the era of personalized oncotherapy.

Int Rev Immunol 2017 11 29;36(6):338-351. Epub 2017 Sep 29.

i Department of Medicine Division of Gastroenterology , University of Washington , Seattle WA , USA.

Current clinical treatment regimens, including many emergent immune strategies (e.g., checkpoint inhibitors) have done little to affect the devastating course of pancreatic ductal adenocarcinoma (PDA). Read More

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http://dx.doi.org/10.1080/08830185.2017.1363199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224292PMC
November 2017
18 Reads

CNS: Not an immunoprivilaged site anymore but a virtual secondary lymphoid organ.

Int Rev Immunol 2018 01 29;37(1):57-68. Epub 2017 Sep 29.

b Department of Microbiology , All India Institute of Medical Sciences , Ansari Nagar (West), New Delhi , India.

The cardinal dogma of central nervous system (CNS) immunology believed brain is an immune privileged site, but scientific evidences gathered so far have overturned this notion proving that CNS is no longer an immune privileged site, but rather an actively regulated site of immune surveillance. Landmark discovery of lymphatic system surrounding the duramater of the brain, made possible by high resolution live imaging technology has given new dimension to neuro-immunology. Here, we discuss the immune privilege status of CNS in light of the previous and current findings, taking into account the differences between a healthy state and changes that occur during an inflammatory response. Read More

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http://dx.doi.org/10.1080/08830185.2017.1357719DOI Listing
January 2018
19 Reads

Damage-associated molecular patterns and their role as initiators of inflammatory and auto-immune signals in systemic lupus erythematosus.

Int Rev Immunol 2017 09 29;36(5):259-270. Epub 2017 Sep 29.

a Grupo de Inmunología Celular e Inmunogenética , Universidad de Antioquia , carrera 53 numero 61-30, Medellin , Colombia.

Damage-associated molecular patterns (DAMPs) are endogenous molecules that are released into the extracellular space under conditions of activation, cellular stress, or tissue damage. These molecules are recognized by pattern-recognition receptors (PRRs) and can induce inflammation and immune responses in the absence of infection. An increasing number of DAMPs have been linked to the pathogenesis of many auto-immune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriatic arthritis, and systemic sclerosis (SSc); as they promote the maturation/activation of different immune cells and pro-inflammatory cytokines production associated with these diseases. Read More

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http://dx.doi.org/10.1080/08830185.2017.1365146DOI Listing
September 2017
14 Reads

AID Biology: A pathological and clinical perspective.

Int Rev Immunol 2018 01 21;37(1):37-56. Epub 2017 Sep 21.

a Centre for Biosciences and Biomedical Engineering , Indian Institute of Technology Indore , Simrol , Indore , Madhya Pradesh , India.

Activation-induced cytidine deaminase (AID), primarily expressed in activated mature B lymphocytes in germinal centers, is the key factor in adaptive immune response against foreign antigens. AID is responsible for producing high-affinity and high-specificity antibodies against an infectious agent, through the physiological DNA alteration processes of antibody genes by somatic hypermutation (SHM) and class-switch recombination (CSR) and functions by deaminating deoxycytidines (dC) to deoxyuridines (dU), thereby introducing point mutations and double-stranded chromosomal breaks (DSBs). The beneficial physiological role of AID in antibody diversification is outweighed by its detrimental role in the genesis of several chronic immune diseases, under non-physiological conditions. Read More

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http://dx.doi.org/10.1080/08830185.2017.1369980DOI Listing
January 2018
10 Reads

The mechanisms of IL-17A on promoting tumor metastasis.

Int Rev Immunol 2017 11 21;36(6):360-369. Epub 2017 Sep 21.

a Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Diseases and Microenvironment of Ministry of Education of China , Tianjin Medical University , Tianjin , China.

In recent decades, extensive studies have indicated that IL-17A plays an important role in tumor progression and metastasis, but the underlying mechanisms are not immediately clear. In this review, we examined the literature from the recent years concerning the study of IL-17A in four kinds of tumor transfer paths, including hematogenous metastasis, lymphatic metastasis, local invasion and transcoelomic metastasis, to summarize the roles and underlying mechanisms of IL-17A on tumor metastasis. Read More

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http://dx.doi.org/10.1080/08830185.2017.1356296DOI Listing
November 2017
17 Reads

Innate immune cells for immunotherapy of autoimmune and cancer disorders.

Int Rev Immunol 2017 11 21;36(6):315-337. Epub 2017 Sep 21.

a Millennium Institute on Immunology and Immunotherapy Santiago , Chile.

Modulation of the immune system has been widely targeted for the treatment of several immune-related diseases, such as autoimmune disorders and cancer, due to its crucial role in these pathologies. Current available therapies focus mainly on symptomatic treatment and are often associated with undesirable secondary effects. For several years, remission of disease and subsequently recovery of immune homeostasis has been a major goal for immunotherapy. Read More

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http://dx.doi.org/10.1080/08830185.2017.1365145DOI Listing
November 2017
58 Reads

Redox-sensitive transcription factors play a significant role in the development of rheumatoid arthritis.

Int Rev Immunol 2018 05 12;37(3):129-143. Epub 2017 Sep 12.

b Biomedicine, College of Public Health, Medical and Veterinary Sciences , James Cook University , Townsville , Queensland , Australia.

Rheumatoid arthritis (RA) is a chronic autoimmune disease which is associated with significant morbidity. Redox sensitive transcription factors including NF-κB, HIF, AP-1, and Nrf2 are intimately involved in the pathogenesis of RA. The treatment of this disease is limited by the elusive nature of the pathogenesis of RA. Read More

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https://www.tandfonline.com/doi/full/10.1080/08830185.2017.1
Publisher Site
http://dx.doi.org/10.1080/08830185.2017.1363198DOI Listing
May 2018
6 Reads

Gastrointestinal manifestations of primary immune deficiencies in children.

Int Rev Immunol 2018 03 6;37(2):111-118. Epub 2017 Sep 6.

b Department of Paediatric Immunology , Great Ormond Street Hospital , London , UK.

Primary immune deficiencies (PID) in children are a rare but serious group of genetic disorders of the immune system which apart from the host's defenses, can also affect every system of the human body, including the gastrointestinal tract. In their severe form they can lead to increased susceptibility to serious infections during infancy and even death. In the less severe form, they can present later in childhood or adolescence with subtle signs and symptoms. Read More

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http://dx.doi.org/10.1080/08830185.2017.1365147DOI Listing
March 2018
10 Reads
4.103 Impact Factor

MicroRNA mediated regulation of immunity against gram-negative bacteria.

Int Rev Immunol 2017 09 11;36(5):287-299. Epub 2017 Aug 11.

a South Texas Center for Emerging Infectious Diseases and Center of Excellence in Infection Genomics , University of Texas at San Antonio , One UTSA Circle, San Antonio , TX.

Evidence over the last couple decades has comprehensively established that short, highly conserved, non-coding RNA species called microRNA (miRNA) exhibit the ability to regulate expression and function of host genes at the messenger RNA (mRNA) level. MicroRNAs play key regulatory roles in immune cell development, differentiation, and protective function. Intrinsic host immune response to invading pathogens rely on intricate orchestrated events in the development of innate and adaptive arms of immunity. Read More

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http://dx.doi.org/10.1080/08830185.2017.1347649DOI Listing
September 2017
24 Reads

Risk factors predisposing to the development of hypogammaglobulinemia and infections post-Rituximab.

Int Rev Immunol 2017 11 11;36(6):352-359. Epub 2017 Aug 11.

c Department of Paediatric Immunology , Great Ormond Street Hospital , London , UK.

Rituximab (RTX) is a monoclonal antibody against CD20, commonly used in the treatment of hematological malignancies and autoimmune diseases. The use of RTX is related to the development of hypogammaglobulinemia and infections. Aim of this review is to summarize the evidence supporting the association of specific risk factors with the development of hypogammaglobulinemia and infections post-RTX. Read More

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http://dx.doi.org/10.1080/08830185.2017.1346092DOI Listing
November 2017
13 Reads
1 Citation
4.103 Impact Factor

Host defenses against metabolic endotoxaemia and their impact on lipopolysaccharide detection.

Int Rev Immunol 2017 05 1;36(3):125-144. Epub 2017 Mar 1.

a Department of Cardiovascular Sciences , Glenfield Hospital, University of Leicester , Leicester , UK.

Bacterial endotoxin (lipopolysaccharide, LPS), is one of the most potent inducers of inflammatory signaling, yet it is abundant in the human gut and the modern diet. Small quantities of LPS routinely translocate from the gut lumen to the circulation (so-called metabolic endotoxaemia), and elevated plasma LPS concentrations are reported in a variety of chronic non-communicable diseases, including obesity, non-alcoholic fatty liver disease, atherosclerosis and type II diabetes. Murine models of experimentally-induced endotoxaemia and Toll-like receptor-4 deficiency suggest that endotoxin may promote the metabolic disturbances that underpin these diseases. Read More

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http://dx.doi.org/10.1080/08830185.2017.1280483DOI Listing
May 2017
3 Reads

Role of MicroRNAs in shaping innate immunity and as therapeutic targets for autoimmune diseases.

Int Rev Immunol 2017 05 10;36(3):123-124. Epub 2017 Jul 10.

b International Reviews of Immunology and Vice President, Translational Sciences , Kite Pharma Inc. , Editor in Chief, Santa Monica , California , USA.

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http://dx.doi.org/10.1080/08830185.2017.1340043DOI Listing
May 2017
4 Reads

Multiple functions of the E3 ubiquitin ligase CHIP in immunity.

Int Rev Immunol 2017 09 2;36(5):300-312. Epub 2017 Jun 2.

a Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences , National Key Laboratory of Medical Molecular Biology & Department of Immunology , Dongcheng District , Beijing , China.

The carboxyl terminal of Hsp70-interacting protein (CHIP) is an E3 ubiquitin ligase that plays a pivotal role in the protein quality control system by shifting the balance of the folding-refolding machinery toward the degradative pathway. However, the precise mechanisms by which nonnative proteins are selected for degradation by CHIP either directly or indirectly via chaperone Hsp70 or Hsp90 are still not clear. In this review, we aim to provide a comprehensive model of the mechanism by which CHIP degrades its substrate in a chaperone-dependent or direct manner. Read More

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http://dx.doi.org/10.1080/08830185.2017.1309528DOI Listing
September 2017
23 Reads

In this issue: Role of immune cells, immune modulating factors and immunotoxins in cancer immunotherapy.

Int Rev Immunol 2017 07 24;36(4):205-206. Epub 2017 May 24.

b Editor in Chief, International Reviews of Immunology and Vice President, Translational Sciences , Kite Pharma Inc. , Santa Monica , California , USA.

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http://dx.doi.org/10.1080/08830185.2017.1326784DOI Listing
July 2017
14 Reads

The predictive value of transforming growth factor-β in Wilms tumor immunopathogenesis.

Int Rev Immunol 2017 07 8;36(4):233-239. Epub 2017 May 8.

a Laboratory of Study and Application of DNA Polymorphisms, Department of Pathological Sciences , Biological Sciences Center, State University of Londrina , Londrina-Paraná , Brazil.

Wilms tumor is the most common kidney malignancy in children, especially in children aged less than 6 years. Although therapeutic approach has reached successful rates, there is still room for improvement. Considering the tumor microenvironment, cytokines represent important elements of interaction and communication between tumor cells, stroma, and immune cells. Read More

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http://dx.doi.org/10.1080/08830185.2017.1291639DOI Listing
July 2017
40 Reads

Role of MicroRNAs in the development and function of innate immune cells.

Int Rev Immunol 2017 05 4;36(3):154-175. Epub 2017 May 4.

a Department of Neonatology , Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER) , Puducherry , India.

MicroRNAs act as crucial post-transcriptional regulators of various biological processes. Their role in regulating the differentiation and development of the various immune cells of the body is of paramount importance. The development of immune cells from the hematopoietic progenitors involves the complex interplay of transcription factors, cell signaling proteins and growth factors. Read More

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http://dx.doi.org/10.1080/08830185.2017.1284212DOI Listing
May 2017
3 Reads
4.103 Impact Factor

Anti-pentraxin antibodies in autoimmune systemic diseases: Focus on anti-pentraxin-3 autoantibodies.

Int Rev Immunol 2017 05 4;36(3):145-153. Epub 2017 May 4.

b Angers University Hospital , University of Angers , Angers , France.

Pentraxins are soluble pattern recognition molecules implicated not only in the opsonization and removal of microorganisms but also in the clearance of modified self (i.e., dying cells). Read More

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http://dx.doi.org/10.1080/08830185.2017.1284210DOI Listing
May 2017
14 Reads