5,898 results match your criteria International Journal of Tuberculosis and Lung Disease[Journal]


First description of and concomitant infection: report of two cases.

Int J Tuberc Lung Dis 2019 Jan 24. Epub 2019 Jan 24.

Medecine Unit, Hôpital médico-chirurgical militaire Bouffard, Djibouti City, Djibouti.

SUMMARY

We report the first two cases of tuberculous coinfection with and . Both patients were young Djiboutian females with pulmonary tuberculosis (TB). One had a miliary pattern with concomitant human immunodeficiency virus infection. Read More

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http://dx.doi.org/10.5588/ijtld.18.0261DOI Listing
January 2019
2 Reads

What causes symptoms suggestive of tuberculosis in HIV-positive people with negative initial investigations?

Int J Tuberc Lung Dis 2019 Jan 24. Epub 2019 Jan 24.

TB Centre, London School of Hygiene & Tropical Medicine, London, UK.

OBJECTIVE

To identify the causes of symptoms suggestive of tuberculosis (TB) among people living with the human immunodeficiency virus (PLHIV) in South Africa.

METHODS

A consecutive sample of HIV clinic attendees with symptoms suggestive of TB (⩾1 of cough, weight loss, fever or night sweats) at enrolment and at 3 months, and negative initial TB investigations, were systematically evaluated with standard protocols and diagnoses assigned using standard criteria. TB was ‘confirmed' if was identified within 6 months of enrolment, and ‘clinical' if treatment started without microbiological confirmation. Read More

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http://dx.doi.org/10.5588/ijtld.18.0251DOI Listing
January 2019
4 Reads

A rare case of bone marrow BCG-itis responding to second-line anti-tuberculosis treatment.

Int J Tuberc Lung Dis 2019 Jan;23(1):119-120

3rd Department of Medicine, GNA 'Sotiria', National and Kapodistrian University of Athens, Athens.

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http://dx.doi.org/10.5588/ijtld.18.0576DOI Listing
January 2019

Respiratory tuberculosis incidence and mortality in Estonia: 30-year trends and sociodemographic determinants.

Int J Tuberc Lung Dis 2019 Jan;23(1):112-118

Department of Epidemiology and Biostatistics.

Objective: To explore time trends in the incidence and mortality of respiratory tuberculosis (TB) over a 30-year period in Estonia, and to evaluate disease disparities according to sex, age, ethnicity and education.

Design: Data from the TB Register and the Causes of Death Register were used to assess time trends in age-standardised incidence and mortality rates. The effect of sociodemographic characteristics on TB risk was modelled using Poisson regression around three population censuses. Read More

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https://www.ingentaconnect.com/content/10.5588/ijtld.18.0388
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http://dx.doi.org/10.5588/ijtld.18.0388DOI Listing
January 2019
4 Reads

Paediatric tuberculosis among the foreign-born: utility of the Canadian TB immigration medical surveillance programme.

Int J Tuberc Lung Dis 2019 Jan;23(1):105-111

Department of Paediatrics, University of Toronto, Toronto, Ontario, Division of Infectious Diseases, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: There are few data on the utility of screening paediatric immigrants for tuberculosis (TB) in low TB burden countries.

Objective: To evaluate the utility of the Canadian immigration medical examination and TB Medical Surveillance (TBMS) for detecting paediatric TB disease.

Design: A 10-year population-based retrospective cohort study of foreign-born children (ages 0-10 years) and adolescents (ages 11-17 years) immigrating to Ontario, Canada, using linked immigration and public health databases. Read More

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http://dx.doi.org/10.5588/ijtld.18.0317DOI Listing
January 2019

Long-term plasma pharmacokinetics of bedaquiline for multidrug- and extensively drug-resistant tuberculosis.

Int J Tuberc Lung Dis 2019 Jan;23(1):99-104

Université Paris Diderot, Sorbonne Paris Cité, Paris, Infection, Antimicrobiens, Modelisation, Evolution, Unité mixte de recherche 1137, Institut national de la santé et de la recherche médicale (INSERM), Paris, Service de Pharmacologie-Toxicologie, Hôpital Bichat-Claude Bernard, AP-HP, Paris.

Setting: Bedaquiline (BDQ) has been approved for the treatment of multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB). For many patients treatment is prolonged beyond the recommended 6 months. The long-term pharmacokinetics of BDQ have yet to be elucidated. Read More

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http://dx.doi.org/10.5588/ijtld.18.0042DOI Listing
January 2019

Cigarette smoking and culture conversion in patients with susceptible and M/XDR-TB.

Int J Tuberc Lung Dis 2019 Jan;23(1):93-98

Division of Clinical Infectious Diseases, Research Centre Borstel, Borstel, German Centre for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel, International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany.

Background: Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide. Active cigarette smoking may have a significant impact on treatment responses to anti-tuberculosis treatment.

Objective: To ascertain the effect of smoking on sputum culture conversion rates following treatment initiation in patients with susceptible, multidrug-resistant and extensively drug-resistant TB (M/XDR-TB). Read More

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http://dx.doi.org/10.5588/ijtld.18.0354DOI Listing
January 2019

Treatment outcomes, diagnostic and therapeutic impact: Xpert vs. smear. A systematic review and meta-analysis.

Int J Tuberc Lung Dis 2019 Jan;23(1):82-92

Centers for Disease Control and Prevention (CDC), Gaborone, Botswana, Division of Tuberculosis Elimination.

Background: Compared with smear microscopy, Xpert MTB/RIF has the potential to reduce delays in tuberculosis (TB) diagnosis and treatment initiation, and improve treatment outcomes. We reviewed publications comparing treatment outcomes of drug-susceptible TB patients diagnosed using Xpert vs. smear. Read More

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http://dx.doi.org/10.5588/ijtld.18.0203DOI Listing
January 2019

Beyond 'cure' and 'treatment success': quality of life of patients with multidrug-resistant tuberculosis.

Int J Tuberc Lung Dis 2019 Jan;23(1):73-81

Médecins Sans Frontières (MSF), Mumbai, India, MSF, Operational Research Unit, Luxembourg City, Luxembourg.

Setting: Two drug-resistant tuberculosis (DR-TB) sites (MSF Clinic, Jupiter Hospital) in Mumbai, India.

Objective: To assess health-related quality of life (HRQoL) and associated factors among DR-TB patients and explore their perspectives about HRQoL.

Design: We used a mixed-methods design: a quantitative cross-sectional questionnaire (the World Health Organization's Quality of Life Brief Questionnaire [WHOQoL-BREF]); and qualitative in-depth interviews for purposively selected patients. Read More

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http://dx.doi.org/10.5588/ijtld.18.0149DOI Listing
January 2019

Prevalence and risk factors of multidrug-resistant tuberculosis in Cubal, Angola: a prospective cohort study.

Int J Tuberc Lung Dis 2019 Jan;23(1):67-72

Infectious Disease Department, Vall d'Hebron University Hospital, Programa de Salut Internacional de l'Institut Català de la Salut Barcelona, Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Although the Republic of Angola is one of the 14 countries figuring in the three high tuberculosis (TB) burden country lists, the true multidrug-resistant TB (MDR-TB) situation is unknown.

Material And Methods: Patients aged 16 years with a diagnosis of pulmonary TB were prospectively enrolled from June 2014 to July 2015. Sputum samples were collected for culture and drug susceptibility testing in all patients, and for Xpert MTB/RIF testing in all previously treated patients and in new patients whose sputum remained smear-positive after 2 months of treatment. Read More

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http://dx.doi.org/10.5588/ijtld.18.0231DOI Listing
January 2019

Elucidating the risk factors for chronic obstructive pulmonary disease: an umbrella review of meta-analyses.

Int J Tuberc Lung Dis 2019 Jan;23(1):58-66

Departments of Hygiene and Epidemiology, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

Chronic obstructive pulmonary disease (COPD) is commonly attributed to smoking, and other potential risk factors are ignored. We aimed to critically appraise the epidemiological credibility of the risk factors for COPD that have been examined in published meta-analyses. We performed a systematic search to capture systematic reviews and meta-analyses of observational studies on environmental factors and biomarkers for risk of COPD. Read More

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https://www.ingentaconnect.com/content/10.5588/ijtld.18.0228
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http://dx.doi.org/10.5588/ijtld.18.0228DOI Listing
January 2019
4 Reads

Is there a connection between gestational diabetes mellitus, human immunodeficiency virus infection, and tuberculosis?

Int J Tuberc Lung Dis 2019 Jan;23(1):19-25

Center for Global Health, Weill Cornell Medicine, New York, New York, USA.

Pregnancy is associated with insulin resistance similar to that found in type 2 diabetes mellitus (DM). The prevalence of gestational diabetes mellitus (GDM) in key tuberculosis (TB) endemic countries, such as India and China, has been increasing rapidly in the last decade and may be higher in human immunodeficiency virus (HIV) infected women. Pregnancy is also an independent risk factor for developing active TB; however, little is known about the interaction of GDM, HIV and TB. Read More

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http://dx.doi.org/10.5588/ijtld.18.0337DOI Listing
January 2019
1 Read

Measuring the economic burden for TB patients in the End TB Strategy and Universal Health Coverage frameworks.

Int J Tuberc Lung Dis 2019 Jan;23(1):5-11

Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.

Tuberculosis (TB) is a disease of poverty. Ensuring access to health care without the risk of financial hardship due to out-of-pocket health care expenditures (Universal Health Coverage [UHC]) is essential for providing accessible care to underprivileged populations, but this is not enough. The End TB Strategy promotes both patient-centred TB services and social protection measures, which aim to mitigate the economic hardship faced by TB patients and their households due to direct medical and non-medical expenditures, as well as to lost income. Read More

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http://dx.doi.org/10.5588/ijtld.18.0318DOI Listing
January 2019
1 Read

Xpert at 8 years: where are we now, and what should we do next?

Authors:
D W Dowdy

Int J Tuberc Lung Dis 2019 Jan;23(1):3-4

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http://dx.doi.org/10.5588/ijtld.18.0717DOI Listing
January 2019

Patients want to live, not merely survive.

Int J Tuberc Lung Dis 2019 Jan;23(1):1-2

International Union Against Tuberculosis and Lung Disease, Paris, France, TB Service, Barts Health NHS Trust, The Royal London Hospital, London, UK, , Email:

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http://dx.doi.org/10.5588/ijtld.18.0811DOI Listing
January 2019
2.315 Impact Factor

Drug resistance in extra-pulmonary tuberculosis in South Korea: comparison with pulmonary tuberculosis.

Int J Tuberc Lung Dis 2019 Jan 8. Epub 2019 Jan 8.

Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.

OBJECTIVE:

To compare the prevalence of and trends in drug resistance in extra-pulmonary tuberculosis (EPTB) and pulmonary tuberculosis (PTB).

METHODS:

We retrospectively analysed the results of phenotypic drug susceptibility testing (DST) in culture-confirmed TB patients from January 2010 to December 2014 at seven university hospitals in South Korea.

RESULTS:

Of 5599 patients included, 320 (5. Read More

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http://dx.doi.org/10.5588/ijtld.18.0109DOI Listing
January 2019
1 Read

Process measure of FAST tuberculosis infection control demonstrates delay in likely effective treatment.

Int J Tuberc Lung Dis 2019 Jan 8. Epub 2019 Jan 8.

Division of Global Health Equity, Brigham & Women's Hospital, Boston, Massachusetts, USA.

SETTING:

The tuberculous infection control strategy, FAST (Find cases Actively, Separate safely and Treat effectively), recommends prompt initiation of likely effective anti-tuberculosis treatment informed by Xpert MTB/RIF results.

OBJECTIVE:

To describe FAST implementation at Quang Nam Provincial TB and Lung Disease Hospital (QNH), Tam Ky, Viet Nam, using time to initiation of effective TB treatment as a process measure.

DESIGN:

Hospital logs were used to calculate the time to likely effective treatment in patients with pulmonary TB (PTB) hospitalised during the study period. Read More

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https://www.ingentaconnect.com/content/10.5588/ijtld.18.0268
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http://dx.doi.org/10.5588/ijtld.18.0268DOI Listing
January 2019
1 Read

Characteristics of miliary tuberculosis in pregnant women after in vitro fertilisation and embryo transfer.

Int J Tuberc Lung Dis 2019 Jan 8. Epub 2019 Jan 8.

Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, China.

OBJECTIVE:

To analyse the clinical characteristics of miliary tuberculosis (TB) in pregnant women after in vitro fertilisation and embryo transfer (IVF-ET).

METHODS:

Six pregnant women with miliary TB after IVF-ET between October 2010 and July 2015 were retrospectively analysed.

RESULTS:

The patients were aged between 29 and 39 years. Read More

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http://dx.doi.org/10.5588/ijtld.18.0223DOI Listing
January 2019
2 Reads

Nutritional assessment and counselling of tuberculosis patients at primary care in India: do we measure up?

Int J Tuberc Lung Dis 2019 Jan 8. Epub 2019 Jan 8.

Department of Community Medicine, Employees State Insurance Corporation Medical College and Post Graduate Institute of Medical Science and Research, Bengaluru, India.

SETTING:

Dakshina Kannada District, coastal South India, under the Revised National Tuberculosis Control Programme (RNTCP).

OBJECTIVE:

To identify the potential and practices at primary health centres (PHCs) for the assessment of nutritional status of patients with tuberculosis (TB), the basic tools used to measure height and weight and the type of nutritional counselling provided.

DESIGN:

A cross-sectional study was conducted with physical verification of availability of height and weight measuring equipment. Read More

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http://dx.doi.org/10.5588/ijtld.18.0333DOI Listing
January 2019

Reviewers-Volume 22, 2018.

Authors:

Int J Tuberc Lung Dis 2018 Dec;22(12):1532-1534

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http://dx.doi.org/10.5588/1027-3719-22.12.1532DOI Listing
December 2018

Walter Werner Holland, 1929-2018.

Authors:
Peter Burney

Int J Tuberc Lung Dis 2018 Dec;22(12):1531

Respiratory Epidemiology and Public Health - National Heart and Lung Institute, Imperial College, London, UK, , Email:

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https://www.ingentaconnect.com/content/10.5588/ijtld.18.0000
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http://dx.doi.org/10.5588/ijtld.18.0000DOI Listing
December 2018
3 Reads

Denny Mitchison, 6 September 1919-2 July 2018.

Authors:
Andrew Nunn

Int J Tuberc Lung Dis 2018 Dec;22(12):1529-1530

MRC Clinical Trials Unit, University College London, London, UK, , Email:

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http://dx.doi.org/10.5588/ijtld.18.0680DOI Listing
December 2018

Adriaan Manten, 1918-2017.

Authors:
Jakko van Ingen

Int J Tuberc Lung Dis 2018 Dec;22(12):1528

Department of Medical Microbiology, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands, , Email:

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http://dx.doi.org/10.5588/ijtld.18.0430DOI Listing
December 2018
2.315 Impact Factor

Pulmonary mucormycosis with bronchial fistula successfully treated with bronchoscopic and medical therapy.

Int J Tuberc Lung Dis 2018 Dec;22(12):1525-1527

Department of Respiratory and Critical Care Medicine, First Hospital of China Medical University, Shenyang, China, hou_, Email:

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https://www.ingentaconnect.com/content/10.5588/ijtld.18.0420
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http://dx.doi.org/10.5588/ijtld.18.0420DOI Listing
December 2018
9 Reads
2.315 Impact Factor

In reply.

Int J Tuberc Lung Dis 2018 Dec;22(12):1524-1525

Epicentre, Paris, France, , Email:

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http://dx.doi.org/10.5588/ijtld.18.0472-2DOI Listing
December 2018

Is 6 months of bedaquiline enough?

Int J Tuberc Lung Dis 2018 Dec;22(12):1523-1524

Special Programme for Research and Training in Tropical Disease (TDR), World Health Organization, Geneva, Switzerland.

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http://dx.doi.org/10.5588/ijtld.18.0472DOI Listing
December 2018

Distinct functions of CXCR3 and CCR4CD4 T-cells accumulated in human tuberculosis pleural fluid.

Int J Tuberc Lung Dis 2018 Dec;22(12):1514-1522

Institute of Immunology, Zhongshan School of Medicine, Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Sun Yat-Sen University, Guangzhou.

Background: Chemokine receptors and their ligands play a prominent role in regulating leucocyte migration. In the local milieu of inflammation, a high concentration of chemokines can recruit different chemokine receptor-expressing lymphocytes.

Objective: To understand the distinct immunological functions of CXC chemokine receptor 3 (CXCR3) and CC chemokine receptor 4 (CCR4) cluster of differentiation 4 (CD4) T-cells accumulated in human tuberculosis (TB) pleural fluid after tuberculous antigen stimulation. Read More

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https://www.ingentaconnect.com/content/10.5588/ijtld.18.0172
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http://dx.doi.org/10.5588/ijtld.18.0172DOI Listing
December 2018
8 Reads

High-resolution melting curve analysis of heat shock protein 65 for identification of mycobacterial isolates.

Int J Tuberc Lung Dis 2018 Dec;22(12):1511-1513

Department of Medical Microbiology.

Infections caused by non-tuberculous mycobacteria (NTM) often escape detection on traditional diagnostics. We evaluated the ability of heat shock protein 65 (65) polymerase chain reaction and high-resolution melting curve (HRMC) analysis to identify and differentiate complex (MTC) from NTM in 150 clinical mycobacterial isolates from extra-pulmonary sites. A hundred MTC and 50 NTM isolates were identified. Read More

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http://dx.doi.org/10.5588/ijtld.18.0164DOI Listing
December 2018

Adverse reactions associated with long-term drug administration in complex lung disease.

Int J Tuberc Lung Dis 2018 Dec;22(12):1505-1510

Centre for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Tokyo, Japan.

Setting: The number of patients with non-tuberculous mycobacterial lung disease (NTM-LD) worldwide has been increasing. complex lung disease (MAC-LD) accounts for 90% of NTM-LD. MAC-LD necessitates long-term treatment, but adverse reactions with long-term administration of drugs are poorly understood. Read More

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http://dx.doi.org/10.5588/ijtld.18.0171DOI Listing
December 2018
2 Reads

Number and cost of hospitalizations with principal and secondary diagnoses of tuberculosis, United States.

Int J Tuberc Lung Dis 2018 Dec;22(12):1495-1504

National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Objective: To estimate the number and cost of hospitalizations with a diagnosis of active tuberculosis (TB) disease in the United States.

Methods: We analyzed the 2014 National In-Patient Sample using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9) codes to identify hospitalizations with a principal (TB-PD) or any secondary discharge (TB-SD) TB diagnosis. We used a generalized linear model with log link and gamma distribution to estimate the cost per TB-PD and TB-SD episode adjusted for patient demographics, insurer, clinical elements, and hospital characteristics. Read More

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http://dx.doi.org/10.5588/ijtld.18.0260DOI Listing
December 2018
2 Reads

The role of chronic viral hepatitis on tuberculosis treatment interruption.

Int J Tuberc Lung Dis 2018 Dec;22(12):1486-1494

TB Control Unit, Department of Respiratory Medicine, Tan Tock Seng Hospital, Singapore.

Background: Tuberculosis (TB) drug-induced liver injury (TB-DILI) usually occurs within 8 weeks of anti-tuberculosis drug initiation. In Singapore, we suspected that the onset of TB drug-induced transaminitis may be confounded with hepatitis C virus (HCV) and hepatitis B (HBV) virus co-infection.

Objective: To determine the impact of HCV/HBV co-infection on the course of treatment in patients with TB treatment interrupted due to transaminitis. Read More

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https://www.ingentaconnect.com/content/10.5588/ijtld.18.0195
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http://dx.doi.org/10.5588/ijtld.18.0195DOI Listing
December 2018
4 Reads

Melioidosis in patients with suspected tuberculosis in Cambodia: a single-center cross-sectional study.

Int J Tuberc Lung Dis 2018 Dec;22(12):1481-1485

International Respiratory and Severe Illness Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.

Setting: Melioidosis- infection-is increasingly recognized in Cambodia, a country with a high incidence of tuberculosis (TB). Melioidosis and TB can be clinically indistinguishable.

Objective: To quantify the proportion of patients with clinically suspected TB who had melioidosis by testing sputum for . Read More

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https://www.ingentaconnect.com/content/10.5588/ijtld.17.0294
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http://dx.doi.org/10.5588/ijtld.17.0294DOI Listing
December 2018
2 Reads

Xpert MTB/RIF associated with improved treatment initiation among patients with smear-negative tuberculosis.

Int J Tuberc Lung Dis 2018 Dec;22(12):1475-1480

The Infectious Diseases Institute, Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.

Background: Delayed diagnosis and treatment initiation of smear-negative tuberculosis (TB) patients can lead to increased morbidity and mortality, particularly among those co-infected with the human immunodeficiency virus (HIV).

Objective: To compare TB treatment initiation among smear-negative presumptive TB patients in the 6 months before and after the introduction of Xpert MTB/RIF testing at five rural tertiary hospitals in Uganda.

Methods: Patient records of the dates and results of sputum analysis were extracted from TB laboratory registers and linked to those on treatment initiation as indicated in the TB treatment registers. Read More

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http://dx.doi.org/10.5588/ijtld.17.0460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306042PMC
December 2018

Treatment outcomes of pre- and extensively drug-resistant tuberculosis in Johannesburg, South Africa.

Int J Tuberc Lung Dis 2018 Dec;22(12):1469-1474

Sizwe Tropical Disease Hospital, Johannesburg, South Africa.

Background: Extensively drug-resistant tuberculosis (XDR-TB) has a poor treatment success rate and high mortality. Multidrug-resistant TB (MDR-TB) has worse outcomes when there is added resistance to second-line injectable drugs (pre-XDR-TB) or fluoroquinolones (pre-XDR-TB).

Objectives: Treatment outcomes in patients with pre-XDR-TB and XDR-TB in a high HIV prevalence area were compared. Read More

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http://dx.doi.org/10.5588/ijtld.18.0205DOI Listing
December 2018

Transmission of multidrug-resistant tuberculosis in Shanghai: roles of residential status.

Int J Tuberc Lung Dis 2018 Dec;22(12):1462-1468

Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Setting: Shanghai is a mega city where 39% of the population comprises internal migrants.

Objective: To examine the different roles played by migrants and permanent residents in the transmission of multidrug-resistant tuberculosis (MDR-TB).

Design: We conducted a population-based cohort study to assess MDR-TB transmission in Shanghai between 1 January 2009 and 31 December 2012 using genotyping and geospatial analyses. Read More

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http://dx.doi.org/10.5588/ijtld.18.0125DOI Listing
December 2018

Twenty years of rifampicin resistance surveillance in Bangladesh: periodic vs. continuous monitoring.

Int J Tuberc Lung Dis 2018 Dec;22(12):1450-1461

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Objective: To analyse 20 years of tuberculosis (TB) drug resistance surveillance, comparing conventional periodic random drug resistance surveys with continuous monitoring, in Damien Foundation-supported districts of Bangladesh.

Design: Retrospective study of data on TB drug resistance from five periodic surveys among newly registered patients vs. continuous monitoring of retreatment patients from 1996 to 2016. Read More

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http://dx.doi.org/10.5588/ijtld.18.0158DOI Listing
December 2018

HIV testing uptake among the household contacts of multidrug-resistant tuberculosis index cases in eight countries.

Int J Tuberc Lung Dis 2018 Dec;22(12):1443-1449

Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Setting: The household contacts (HHCs) of multidrug-resistant tuberculosis (MDR-TB) index cases are at high risk of tuberculous infection and disease progression, particularly if infected with the human immunodeficiency virus (HIV). HIV testing is important for risk assessment and clinical management.

Methods: This was a cross-sectional, multi-country study of adult MDR-TB index cases and HHCs. Read More

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http://dx.doi.org/10.5588/ijtld.18.0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364692PMC
December 2018
1 Read

Cost-effectiveness of universal isoniazid preventive therapy among HIV-infected pregnant women in South Africa.

Int J Tuberc Lung Dis 2018 Dec;22(12):1435-1442

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA, Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Objective: To estimate the incremental cost-effectiveness of universal vs. test-directed treatment of latent tuberculous infection (LTBI) among human immunodeficiency virus (HIV) positive pregnant women in South Africa.

Methods: We compared tuberculin skin test (TST) directed isoniazid preventive therapy (IPT) (TST placement with delivery of IPT to women with positive results) against QuantiFERON-TB Gold In-Tube (QGIT) directed IPT and universal IPT using decision analysis. Read More

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http://dx.doi.org/10.5588/ijtld.18.0370DOI Listing
December 2018

Clinical variables associated with indeterminate QuantiFERON-TB Gold assay results: role of pre-incubation delay.

Int J Tuberc Lung Dis 2018 Dec;22(12):1429-1434

Department of Pathology, UMass Memorial Medical Center, Worcester, Massachusetts, Quest Diagnostics, North Region, Marlborough, Massachusetts, USA.

Setting: The QuantiFERON-TB Gold (QFT) assay is an interferon-gamma release assay used for the clinical diagnosis of latent tuberculous infection. Relatively high rates of indeterminate results are a significant downside of the test.

Objective: To evaluate clinical variables associated with lower QFT-indeterminate rates after reducing pre-incubation delay. Read More

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http://dx.doi.org/10.5588/ijtld.18.0914DOI Listing
December 2018
1 Read

Three-month weekly rifapentine plus isoniazid for tuberculosis preventive treatment: a systematic review.

Int J Tuberc Lung Dis 2018 Dec;22(12):1422-1428

Global TB Programme.

Background: Uptake of preventive treatment for tuberculosis (TB) remains poor. A 3-month regimen of rifapentine (RPT) plus isoniazid (INH) (3HP) could facilitate its scale-up. We conducted a systematic review to assess the effects of 3HP compared with daily 6- or 9-month INH monotherapy. Read More

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http://dx.doi.org/10.5588/ijtld.18.0168DOI Listing
December 2018

Clinical management of combined tuberculosis and diabetes.

Int J Tuberc Lung Dis 2018 Dec;22(12):1404-1410

International Union Against Tuberculosis and Lung Disease, Paris, France, London School of Hygiene & Tropical Medicine, London, UK.

Optimal management of combined tuberculosis (TB) and diabetes (DM) is important but challenging in terms of achieving good disease outcomes and avoiding toxicity, drug interactions and other challenges. DM management during anti-tuberculosis treatment, aimed at improving TB treatment outcomes and reducing DM-related morbidity and mortality, consists of glycaemic control and measures to reduce the risk of cardiovascular disease. Metformin, the glucose-lowering drug of choice for TB patients, has no meaningful interaction with rifampicin (RMP), and may reduce TB mortality. Read More

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http://dx.doi.org/10.5588/ijtld.18.0340DOI Listing
December 2018
5 Reads

The impact of migration on tuberculosis in the United States.

Int J Tuberc Lung Dis 2018 Dec;22(12):1392-1403

Center for Health Policy and Center for Primary Care and Outcomes Research, Stanford University, Stanford, California, USA.

Due to greater exposure to infection before migration, migrants moving to low-incidence settings can experience substantially higher tuberculosis (TB) rates than the native-born population. This review describes the impact of migration on TB epidemiology in the United States, and how the TB burden differs between US-born and non-US-born populations. The United States has a long history of receiving migrants from other parts of the world, and TB among non-US-born individuals now represents the majority of new TB cases. Read More

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http://dx.doi.org/10.5588/ijtld.17.0185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353558PMC
December 2018

Taking tuberculosis seriously requires that we take poverty seriously: reinstating the ethics of public health.

Int J Tuberc Lung Dis 2018 Dec;22(12):1390-1391

Swiss Tropical and Public Health Institute, Basel, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.5588/ijtld.18.0604DOI Listing
December 2018

Causal inference studies: improving the quality of evidence.

Authors:
Guy Marks

Int J Tuberc Lung Dis 2018 Dec;22(12):1389

Editor, LD.

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http://dx.doi.org/10.5588/ijtld.18.0711DOI Listing
December 2018

World AIDS Day: know your status.

Int J Tuberc Lung Dis 2018 Dec;22(12):1388

The Union HIV Section chair, KNCV Tuberculosis Foundation, The Hague, The Netherlands.

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http://dx.doi.org/10.5588/ijtld.18.0706DOI Listing
December 2018
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A new era for global tuberculosis: holding leaders accountable for promises.

Int J Tuberc Lung Dis 2018 Dec;22(12):1387

International Union Against Tuberculosis and Lung Disease, Paris, France.

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http://dx.doi.org/10.5588/ijtld.18.0702DOI Listing
December 2018

Pharmacokinetics of isoniazid in Indian children with tuberculosis on daily treatment.

Int J Tuberc Lung Dis 2019 Jan 20;23(1):52-57. Epub 2018 Dec 20.

Department of Clinical Pharmacology, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, India.

Objective: To assess the pharmacokinetics of isoniazid (INH) at 10 mg/kg/day among Indian children.

Methods: INH levels were estimated using liquid chromatography-tandem mass spectroscopy in 35 children aged 1-15 years on daily anti-tuberculosis treatment. Blood samples were collected 0, 1, 2, 3, 6 and 24 h after INH administration. Read More

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http://dx.doi.org/10.5588/ijtld.18.0463DOI Listing
January 2019
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Impact of socio-economic inequities on tuberculosis in a Southern European city: what is the effect of the recession?

Int J Tuberc Lung Dis 2019 Jan 20;23(1):45-51. Epub 2018 Dec 20.

Epidemiology Service, Agència de Salut Pública de Barcelona, Barcelona, Foundation of Tuberculosis Research Unit of Barcelona, Barcelona.

Introduction: Economic crises affect a population's health, particularly among the most deprived. The increase in health inequalities in the latest recession may have influenced the incidence of tuberculosis (TB). We analysed the effect of socio-economic inequities and recession on TB incidence in Barcelona, Spain. Read More

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http://dx.doi.org/10.5588/ijtld.18.0110DOI Listing
January 2019
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Interaction between C-Tb and PPD given concomitantly in a split-body randomised controlled trial.

Int J Tuberc Lung Dis 2019 Jan 20;23(1):38-44. Epub 2018 Dec 20.

University of Cape Town, Cape Town, South Africa.

Setting: Seven tuberculosis (TB) clinics in South Africa.

Objective: As both purified protein derivative (PPD) and a -specific skin test (C-Tb) contain region of difference 1 (RD1) antigens, we conducted a study to evaluate whether there was any interaction between the two during concomitant and separate administration in patients with newly diagnosed culture-positive TB.

Design: Adult patients with active TB ( = 456, 20% human immunodeficiency virus infected) were randomised to receive only C-Tb, only PPD, or concomitant injection of both C-Tb and PPD using the Mantoux technique. Read More

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http://dx.doi.org/10.5588/ijtld.18.0137DOI Listing
January 2019

Sputum smear microscopy in the Xpert MTB/RIF era.

Int J Tuberc Lung Dis 2019 Jan 19;23(1):12-18. Epub 2018 Dec 19.

Tuberculosis Consultant Services, Kirchlindach, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

A balanced perspective is advocated for the assessment and application of the most recent and the oldest diagnostic methods for pulmonary tuberculosis (TB)-the molecular Xpert MTB/RIF assay and microscopy for acid-fast bacilli. We discuss their respective merits and shortcomings and identify threats that may hamper their use in TB control. Neither test on its own provides all the information needed for diagnosis and treatment monitoring. Read More

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http://dx.doi.org/10.5588/ijtld.18.0553DOI Listing
January 2019