5,931 results match your criteria International Journal of Tuberculosis and Lung Disease[Journal]


Discordant rifampicin susceptibility results are associated with Xpert MTB/RIF probe B and probe binding delay.

Int J Tuberc Lung Dis 2019 Mar;23(3):358-362

Department of Medicine, Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA.

Setting: Xpert MTB/RIF is the first-line diagnostic test for and rifampicin (RIF) resistance in South Africa.

Objective: To describe the rates of Xpert RIF resistance not confirmed on follow-up testing, as well as the patient and test characteristics associated with discordant results.

Design: Retrospective review of patients with isolates showing Xpert RIF resistance. Read More

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http://dx.doi.org/10.5588/ijtld.16.0837DOI Listing
March 2019
1 Read

Hear this! Audiometry testing saves the hearing of a patient with drug-resistant tuberculosis.

Int J Tuberc Lung Dis 2019 Mar;23(3):378-379

ALERT (All Africa Leprosy, Tuberculosis and Rehabilitation Training Centre), Addis Ababa, Ethiopia, Emawayish Tesema, Challenge TB/KNCV TB Foundation, ALERT, P O Box 165, Addis Ababa, Ethiopia., , Email:

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http://dx.doi.org/10.5588/ijtld.18.0558DOI Listing
March 2019
4 Reads

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Int J Tuberc Lung Dis 2019 Mar;23(3):371-377

Johns Hopkins University Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, Johns Hopkins University Technical Support for Ethiopian HIV/AIDS Initiative, Addis Ababa.

Setting: Sixty-seven government health facilities providing tuberculosis (TB) and human immunodeficiency virus (HIV) services across Ethiopia.

Objective: To examine clinician barriers to implementing isoniazid preventive therapy (IPT) among people living with HIV.

Design: A cross-sectional study to evaluate the provider-related factors associated with high IPT coverage at the facility level. Read More

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http://dx.doi.org/10.5588/ijtld.18.0378DOI Listing
March 2019
3 Reads

Spatial epidemiology of tuberculosis in the high-burden counties of Kisumu and Siaya, Western Kenya, 2012-2015.

Int J Tuberc Lung Dis 2019 Mar;23(3):363-370

United States Army Medical Research Directorate-Kenya, Nairobi, Kenya.

Background: Effective management of tuberculosis (TB) and reduction of TB incidence relies on knowledge of where, when and to what degree the disease is present.

Methods: In a retrospective cross-sectional study, we analysed the spatial distribution of notified TB incidence from 1 January 2012 and 31 December 2015 in Siaya and Kisumu Counties, Western Kenya. TB data were obtained from the Division of Leprosy, Tuberculosis and Lung Disease, Nairobi, Kenya, as part of an approved TB case detection study. Read More

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http://dx.doi.org/10.5588/ijtld.18.0245DOI Listing

High prevalence and incidence of tuberculosis in people living with the HIV in Mandalay, Myanmar, 2011-2017.

Int J Tuberc Lung Dis 2019 Mar;23(3):349-357

National AIDS Programme, Ministry of Health and Sports, Naypyitaw, Myanmar.

Setting: Two human immunodeficiency virus (HIV) clinics providing antiretroviral therapy (ART), Mandalay, Myanmar.

Objective: To assess prevalent TB at enrolment, incident TB during follow-up and associated risk factors in adult people living with HIV (PLHIV) between 2011 and 2017.

Design: Cohort study using secondary data. Read More

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http://dx.doi.org/10.5588/ijtld.18.0436DOI Listing
March 2019
2 Reads

Effect of neonatal bacille Calmette-Guérin on the tuberculin skin test reaction in the first 2 years of life.

Int J Tuberc Lung Dis 2019 Mar;23(3):344-348

Paediatric Pulmonology Unit, Pontifícia Universidade Católica do Rio Grande do Sul, Santa Cruz do Sul, Rio Grande do Sul, Brazil.

Setting: Latent tuberculous infection (LTBI) is an important reservoir of disease reactivation that is sufficient to generate new cases for decades. The tuberculin skin test (TST) is an important tool to diagnose LTBI; however, neonatal bacille Calmette-Guérin (BCG) vaccination may impact interpretation of TST data.

Objectives: To analyse the effect of the neonatal BCG vaccine on TST reaction in the first 2 years of life in children with no identified contact with tuberculosis (TB). Read More

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http://dx.doi.org/10.5588/ijtld.18.0201DOI Listing
March 2019
7 Reads

Contacts of underserved tuberculosis patients have higher odds of TB disease in North West England: a cohort study.

Int J Tuberc Lung Dis 2019 Mar;23(3):337-343

Public Health England Field Service North West, Liverpool.

Objective: To investigate the association between patients' social risk factors and the risk of tuberculous infection and TB disease among their contacts in England.

Design: This was a cohort study of all TB cases from North West England diagnosed between 27 March 2012 and 28 June 2016. The social risk factors of TB cases were evaluated to estimate their need for enhanced case management (ECM), from 0 (standard of care) to 3 (intensive social support). Read More

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http://dx.doi.org/10.5588/ijtld.18.0467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421945PMC
March 2019
3 Reads

Risk factors for unfavourable treatment outcomes among rifampicin-resistant tuberculosis patients in Tajikistan.

Int J Tuberc Lung Dis 2019 Mar;23(3):331-336

Technical Division, Team Evidence, KNCV Tuberculosis Foundation, The Hague, The Netherlands, Department of Public Health, Epidemiology, and Biostatistics, David Tvildiani Medical University, Tbilisi, Georgia.

Setting: Tajikistan is among the 30 countries with the highest multidrug-resistant tuberculosis (MDR-TB) burden.

Objective: To investigate the risk factors for unfavourable treatment outcomes among rifampicin-resistant (RR)/MDR-TB patients.

Design: Retrospective medical chart review of RR/MDR-TB patients enrolled for treatment in 2012-2013. Read More

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http://dx.doi.org/10.5588/ijtld.18.0311DOI Listing
March 2019
5 Reads

IPT in people living with HIV in Myanmar: a five-fold decrease in incidence of TB disease and all-cause mortality.

Int J Tuberc Lung Dis 2019 Mar;23(3):322-330

The Union, Paris, France, London School of Hygiene & Tropical Medicine, London, UK.

Setting: Myanmar, a country with a high human immunodeficiency virus-tuberculosis (HIV-TB) burden, where the tuberculin skin test or interferon-gamma release assays are not routinely available for the diagnosis of latent tuberculous infection.

Objective: To assess the effect of isoniazid (INH) preventive therapy (IPT) on the risk of TB disease and mortality among people living with HIV (PLHIV).

Design: A retrospective cohort study of routinely collected data on PLHIV enrolled into care between 2009 and 2014. Read More

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http://dx.doi.org/10.5588/ijtld.18.0448DOI Listing
March 2019
7 Reads

Initiation of anti-tuberculosis treatment in children following gastric aspirate testing, Botswana, 2008-2012.

Int J Tuberc Lung Dis 2019 Mar;23(3):315-321

Botswana-UPenn Partnership, Gaborone, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Setting: Diagnosing pediatric tuberculosis (TB) is difficult; to improve diagnosis gastric aspiration (GA) was performed in 121 Botswana health facilities.

Objective: To describe treatment initiation and outcomes in children with a positive GA result and those treated empirically.

Methods: Children with smear or culture-positive GA or those clinically diagnosed were referred for anti-tuberculosis treatment. Read More

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http://dx.doi.org/10.5588/ijtld.18.0404DOI Listing
March 2019
5 Reads

HIV-related tuberculosis: mortality risk in persons without vs. with culture-confirmed disease.

Int J Tuberc Lung Dis 2019 Mar;23(3):306-314

Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Background: Tuberculosis (TB) diagnosis in human immunodeficiency virus (HIV) positive persons is difficult, particularly in resource-limited settings. The relationship between TB culture status and mortality in HIV-positive persons treated for TB is unclear.

Methods: We evaluated HIV-positive adults treated for TB at or after their first HIV clinic visit in Argentina, Brazil, Chile, Honduras, Mexico or Peru from 2000 to 2015. Read More

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http://dx.doi.org/10.5588/ijtld.18.0111DOI Listing
March 2019
1 Read

variants and toxicity related to anti-tuberculosis agents: a systematic review and meta-analysis.

Int J Tuberc Lung Dis 2019 Mar;23(3):293-305

Department of Biostatistics, University of Liverpool, Liverpool.

Background: Tuberculosis (TB) patients receiving anti-tuberculosis treatment may experience serious adverse drug reactions (ADRs) such as hepatotoxicity. Variants of the -acetyltransferase 2 () gene may increase the risk of experiencing such toxicity events.

Objective: To provide a comprehensive evaluation of the evidence base for associations between variants and anti-tuberculosis drug-related toxicity. Read More

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http://dx.doi.org/10.5588/ijtld.18.0324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421944PMC

Point of care HbA level for diabetes mellitus management and its accuracy among tuberculosis patients: a study in four countries.

Int J Tuberc Lung Dis 2019 Mar;23(3):283-292

Population Health Research Institute, St George's University of London, London.

Background: Diabetes mellitus (DM) is common among tuberculosis (TB) patients and often undiagnosed or poorly controlled. We compared point of care (POC) with laboratory glycated haemoglobin (HbA) testing among newly diagnosed TB patients to assess POC test accuracy, safety and acceptability in settings in which immediate access to DM services may be difficult.

Methods: We measured POC and accredited laboratory HbA (using high-performance liquid chromatography) in 1942 TB patients aged 18 years recruited from Peru, Romania, Indonesia and South Africa. Read More

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http://dx.doi.org/10.5588/ijtld.18.0359DOI Listing
March 2019
3 Reads

TB or not TB? Challenges in diagnosing and treating maternal and neonatal tuberculosis.

Int J Tuberc Lung Dis 2019 Mar;23(3):280-282

TB-HIV Department, International Union Against Tuberculosis and Lung Disease, Paris, France.

We present the case of a pregnant woman who died from disseminated tuberculosis (TB), and the difficulties encountered in diagnosing TB disease in her newborn. We discuss the burden of maternal and neonatal TB and the need for a different approach, one that is not solely based on bacteriologic evidence which, in most cases, tends to be inconclusive. We also explore the difficulties physicians and national TB programs face in managing and developing effective policies for these two highly vulnerable and neglected populations. Read More

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http://dx.doi.org/10.5588/ijtld.18.0548DOI Listing

Spatial epidemiology for tuberculosis surveillance: a relevant add-on to routine surveillance.

Int J Tuberc Lung Dis 2019 Mar;23(3):278-279

Centro de Investigação em Saude de Manhiça, Vila da Manhiça, Maputo Province, Mozambique, ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain, Amsterdam Institute for Global Health and Development, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.5588/ijtld.19.0104DOI Listing

Another aetiology for tuberculosis-beyond the .

Int J Tuberc Lung Dis 2019 Mar;23(3):277

Respiratory Diseases Clinical Epidemiology Unit, Istituti Clinici Scientifici Maugeri (Istituto di Ricovero e Cura a Carattere Scientifico), Tradate, Italy.

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http://dx.doi.org/10.5588/ijtld.19.0076DOI Listing

The mortality rates for tuberculosis remain high even in high-income countries.

Authors:
Y-S Kwon W-J Koh

Int J Tuberc Lung Dis 2019 Mar;23(3):275-276

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

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http://dx.doi.org/10.5588/ijtld.19.0061DOI Listing

polymorphisms confer susceptibility to pulmonary tuberculosis in a Chinese population.

Int J Tuberc Lung Dis 2019 Feb;23(2):265-271

Shanghai Key Laboratory of Mycobacterium Tuberculosis, Department of Clinical Laboratory, Shanghai Pulmonary Hospital Affiliated to Tongji University School of Medicine, Shanghai.

Objective: The autophagy pathway is a critical process in infection, and can be regulated by uncoordinated 51-like kinase 1 (ULK1). We investigated the associations between single-nucleotide polymorphisms (SNPs) in and risk of tuberculosis (TB) in a Chinese Han population.

Design: We recruited 380 pulmonary tuberculosis (PTB) cases, 242 extra-pulmonary tuberculosis (EPTB) cases and 606 healthy controls from a Chinese Han population and sequenced . Read More

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http://dx.doi.org/10.5588/ijtld.18.0174DOI Listing
February 2019
1 Read

Clinical evaluation of TRCReady M.TB for rapid automated detection of complex in respiratory samples.

Int J Tuberc Lung Dis 2019 Feb;23(2):260-264

Laboratory of Microbiology and Cell Factory.

Setting: Timely diagnosis of tuberculosis (TB) is essential for effectively controlling and managing the disease. Although international guidelines recommend acid-fast bacilli staining and culture as the 'gold standard', new molecular methods are available to safely and rapidly identify positive samples.

Objective: To evaluate the performance of the newer and fully automated version of a molecular assay for rRNA amplification (TRCReady M. Read More

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http://dx.doi.org/10.5588/ijtld.18.0355DOI Listing
February 2019

Mortality among tuberculosis patients in New York City.

Int J Tuberc Lung Dis 2019 Feb;23(2):252-259

Department of Epidemiology Columbia University Mailman School of Public Health, New York, New York, New York City Department of Health and Mental Hygiene, Bureau of Tuberculosis Control, Queens, New York, USA.

Objectives: To quantify tuberculosis (TB) related mortality among TB patients in New York City (NYC), NY, USA, and identify risk factors associated with TB-related mortality.

Design: We performed a retrospective analysis of verified TB patients in NYC, 2004-2013. NYC Office of Vital Statistics death certificate data and TB surveillance data were matched. Read More

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http://dx.doi.org/10.5588/ijtld.18.0305DOI Listing
February 2019
1 Read

Challenges and opportunities to prevent tuberculosis in people living with HIV in low-income countries.

Int J Tuberc Lung Dis 2019 Feb;23(2):241-251

International Union Against Tuberculosis and Lung Disease (The Union), Paris, France.

People living with the human immunodeficiency virus (HIV) (PLHIV) are at high risk for tuberculosis (TB), and TB is a major cause of death in PLHIV. Preventing TB in PLHIV is therefore a key priority. Early initiation of antiretroviral therapy (ART) in asymptomatic PLHIV has a potent TB preventive effect, with even more benefits in those with advanced immunodeficiency. Read More

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http://dx.doi.org/10.5588/ijtld.18.0207DOI Listing
February 2019
1 Read

A case of rifampicin-induced haemolysis.

Int J Tuberc Lung Dis 2019 Feb;23(2):239-240

University Hospital Monklands, Airdrie, Scotland, UK.

We present a case of pulmonary tuberculosis treated with a rifampicin (RMP) containing regimen, which led to marked haemolysis and acute kidney injury. The patient was shown to have RMP-induced haemolysis on detailed immunological testing. RMP is described as a rare cause of drug-induced haemolysis in the literature. Read More

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http://dx.doi.org/10.5588/ijtld.18.0255DOI Listing
February 2019
2 Reads

A case promoting use of ultrasound-guided sampling techniques to correctly diagnose MDR-TB in children.

Int J Tuberc Lung Dis 2019 Feb;23(2):236-238

Department of Paediatric Infectious Disease and Immunology, Amalia Children's Hospital, Radboud University Medical Centre (Radboudumc), Nijmegen, Radboudumc Institute for Molecular Life Sciences, Nijmegen.

A paediatric case of multidrug-resistant tuberculosis in which endo-oesophageal ultrasound-guided fine-needle aspiration using an endobronchial ultrasound-guided bronchoscope was used to collect a sample for microbial analyses is presented. In our experience, ultrasound-guided sampling techniques, both endo-oesophageal and endobronchial, can be safely used for the diagnosis of paediatric intrathoracic tuberculous lymphadenopathy in children aged 3 years. Interventional pulmonologists with experience in using these techniques should be part of the multidisciplinary team treating these patients. Read More

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http://dx.doi.org/10.5588/ijtld.18.0322DOI Listing
February 2019
1 Read

Tuberculosis remains a public health problem in Romania.

Int J Tuberc Lung Dis 2019 Feb;23(2):226-231

Department of Pneumology, University of Medicine and Pharmacy, Craiova.

Background: Tuberculosis (TB) remains a major public health problem in Romania, which has the highest TB incidence in the European Union.

Methods: We undertook a retrospective study to describe changing trends in the main epidemiological indicators of TB in Romania from 1995 to 2016. Data were obtained from the Marius Nasta Institute of Pneumology, Bucharest, official data published by the National Center for Public Health Statistics and Informatics in Health Statistics Yearbooks, the European Health For All database and the World Health Organization 2017 global TB report. Read More

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http://dx.doi.org/10.5588/ijtld.18.0270DOI Listing
February 2019
1 Read

Rapid direct drug susceptibility testing of based on culture droplet digital polymerase chain reaction.

Int J Tuberc Lung Dis 2019 Feb;23(2):219-225

Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan.

Setting: Early diagnosis and drug susceptibility testing are important for anti-tuberculosis treatment.

Objective: To develop a rapid method for detecting and drug susceptibility based on culture and droplet digital polymerase chain reaction (ddPCR).

Design: in 102 sputum samples was detected using ddPCR, Xpert, quantitative PCR (qPCR) and MGIT™ 960™. Read More

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http://dx.doi.org/10.5588/ijtld.18.0182DOI Listing
February 2019
4 Reads

Toll-like receptors blocking restores in vitro microbicidal activity in latent tuberculosis-infected subjects.

Int J Tuberc Lung Dis 2019 Feb;23(2):212-218

Cellular and Molecular Immunology Laboratory, Núcleo de Doenças Infecciosas (NDI), Universidade Federal do Espírito Santo (UFES), Vitória.

Background: Latent tuberculous infection (LTBI) can function as a 'reservoir' for . Given that T-regulatory cell (T) numbers are augmented in LTBI, it is likely that Toll-like receptors (TLRs) may have a role in T function. Elucidation of the immune mechanisms associated with tuberculosis (TB) development may help to control spreadOBJECTIVE: To investigate the role of TLR2, TLR4 and TLR9 in hindered in vitro microbicidal activity and increase T number during LTBI. Read More

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http://dx.doi.org/10.5588/ijtld.18.0392DOI Listing
February 2019
1 Read

Chronic lung disease in adult recurrent tuberculosis survivors in Zimbabwe: a cohort study.

Int J Tuberc Lung Dis 2019 Feb;23(2):203-211

Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, USA.

Objective: To examine the prevalence and magnitude of chronic lung disease (CLD) and its association with empiric anti-tuberculosis treatment (due to lack of bacteriologic confirmation) among recurrent tuberculosis (TB) survivors in a human immunodeficiency virus (HIV) prevalent setting.

Methods: Prospective cohort study of retreatment TB survivors in Harare, Zimbabwe. At median follow-up of 2 years post-treatment initiation, we characterized mortality, respiratory impairment, and mental health. Read More

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http://dx.doi.org/10.5588/ijtld.18.0313DOI Listing
February 2019
2 Reads

Prevalence of lung function impairment in cured pulmonary tuberculosis patients in Cotonou, Benin.

Int J Tuberc Lung Dis 2019 Feb;23(2):195-202

Bordeaux Population Health Centre, Centre Institut national de la Santé et de la Recherche médicale Unité 1219, Université de Bordeaux, Bordeaux, France.

Setting: National teaching hospital for the management of respiratory diseases, Cotonou, Benin.

Objective: 1) To estimate the prevalence of lung function impairment (LFI) and associated factors in patients cured of pulmonary tuberculosis (PTB); and 2) to determine the link between human immunodeficiency virus (HIV) infection and LFI occurrence.

Design: We performed a cross-sectional study in cured patients with smear-positive TB (PTB+) treated between 2012 and 2015. Read More

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http://dx.doi.org/10.5588/ijtld.18.0234DOI Listing
February 2019
4 Reads

HIV infection and unknown HIV status among tuberculosis patients in Ethiopia: a systematic review and meta-analysis.

Int J Tuberc Lung Dis 2019 Feb;23(2):187-194

University Medical Center Groningen, Department of Epidemiology, University of Groningen, Groningen, The Netherlands.

Background And Objective: Each case of human immunodeficiency virus (HIV) infection worsens the global HIV situation, leads to the failure to achieve tuberculosis (TB) control targets worldwide, and impacts on the use of health service resources. We determined the prevalence of HIV infection among TB patients and the proportion of TB patients with unknown HIV status in Ethiopia.

Methods: We searched PubMed, EMBASE, Google Scholar and Web of Science electronic databases. Read More

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http://dx.doi.org/10.5588/ijtld.18.0363DOI Listing
February 2019
1 Read

Epidemiological and spatial factors for tuberculosis: a matched case-control study in Nagata, Japan.

Int J Tuberc Lung Dis 2019 Feb;23(2):181-186

Department of Public Health, Graduate School of Health Sciences, Kobe University, Hyogo.

Setting And Objective: Several studies have found a significant association between tuberculosis (TB) and spatial factors. We wished to determine the effect of host-related factors and spatial factors associated with an increased risk of TB, and to assess spatial clustering.

Design: A hospital-based case-control study using medical records was conducted. Read More

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http://dx.doi.org/10.5588/ijtld.18.0369DOI Listing
February 2019
1 Read

Multidrug-resistant tuberculosis over 20 years at a referral hospital in South Korea: trends and outcomes.

Int J Tuberc Lung Dis 2019 Feb;23(2):174-180

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul.

Setting: A referral centre in South Korea.

Objective: To investigate trends in drug resistance, treatment modalities and outcomes, and adverse events of multidrug-resistant tuberculosis (MDR-TB) over two decades.

Design: MDR-TB patients treated at Seoul National Hospital University between 1996 and 2015 were divided into four 5-year cohorts according to the date of initial diagnosis. Read More

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http://dx.doi.org/10.5588/ijtld.18.0295DOI Listing
February 2019
1 Read

Genetic diversity and drug resistance of in Ecuador.

Int J Tuberc Lung Dis 2019 Feb;23(2):166-173

Pontificia Universidad Católica del Ecuador, Quito.

Background: The genetic diversity of in Quito, Ecuador is not well known.

Objective: To investigate mutations related to drug resistance and bacterial genotypes in strains in Ecuador.

Design: This was a retrospective study of isolates from 104 patients. Read More

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http://dx.doi.org/10.5588/ijtld.18.0095DOI Listing
February 2019
1 Read

Health care gaps in the global burden of drug-resistant tuberculosis.

Int J Tuberc Lung Dis 2019 Feb;23(2):125-135

International Union Against TB and Lung Disease, Paris, France.

The drug-resistant tuberculosis (DR-TB) cascade-from estimated or incident cases to numbers successfully treated or disease-free survival-has long been characterised by sharp declines at each step in the cascade. The losses along the cascade vary across different settings, and the reasons why some countries have a higher burden of DR-TB are complex and multifactorial; broadly, weak health systems, inadequate financing and poverty all impact differential access to DR-TB care. Within a human rights framework that mandates the right to health and the right to benefit from scientific progress, the aim of this review is to focus on describing inequities in access to DR-TB care at critical points in the cascade. Read More

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http://dx.doi.org/10.5588/ijtld.18.0866DOI Listing
February 2019
2 Reads

Launching the Global TB Network.

Int J Tuberc Lung Dis 2019 Feb;23(2):123-124

International Union Against Tuberculosis and Lung Disease, Paris, France, Department of Medicine, Therapeutics, Dermatology and Psychiatry, Kenyatta University, Nairobi, Kenya.

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http://dx.doi.org/10.5588/ijtld.18.0648DOI Listing
February 2019
1 Read

First description of and concomitant infection: report of two cases.

Int J Tuberc Lung Dis 2019 Feb 24;23(2):232-235. Epub 2019 Jan 24.

Medecine Unit, Hôpital médico-chirurgical militaire Bouffard, Djibouti City, Djibouti, Respiratory Diseases Unit, HIA Laveran, Marseille, Groupe pour la recherche et d'enseignement en Pneumo-infectiologie de la Société de Pneumologie de langue française, Paris, France.

We report the first two cases of tuberculous coinfection with and . Both patients were young Djiboutian females with pulmonary tuberculosis (TB). One had a miliary pattern with concomitant human immunodeficiency virus infection. Read More

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http://dx.doi.org/10.5588/ijtld.18.0261DOI Listing
February 2019
3 Reads

What causes symptoms suggestive of tuberculosis in HIV-positive people with negative initial investigations?

Int J Tuberc Lung Dis 2019 Feb 24;23(2):157-165. Epub 2019 Jan 24.

TB Centre, London School of Hygiene & Tropical Medicine, London, UK, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Africa Health Research Institute, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa.

Objective: To identify the causes of symptoms suggestive of tuberculosis (TB) among people living with the human immunodeficiency virus (PLHIV) in South Africa.

Methods: A consecutive sample of HIV clinic attendees with symptoms suggestive of TB (1 of cough, weight loss, fever or night sweats) at enrolment and at 3 months, and negative initial TB investigations, were systematically evaluated with standard protocols and diagnoses assigned using standard criteria. TB was 'confirmed' if was identified within 6 months of enrolment, and 'clinical' if treatment started without microbiological confirmation. Read More

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http://dx.doi.org/10.5588/ijtld.18.0251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394279PMC
February 2019
14 Reads

A rare case of bone marrow BCG-itis responding to second-line anti-tuberculosis treatment.

Int J Tuberc Lung Dis 2019 Jan;23(1):119-120

3rd Department of Medicine, GNA 'Sotiria', National and Kapodistrian University of Athens, Athens.

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http://dx.doi.org/10.5588/ijtld.18.0576DOI Listing
January 2019

Respiratory tuberculosis incidence and mortality in Estonia: 30-year trends and sociodemographic determinants.

Int J Tuberc Lung Dis 2019 Jan;23(1):112-118

Department of Epidemiology and Biostatistics.

Objective: To explore time trends in the incidence and mortality of respiratory tuberculosis (TB) over a 30-year period in Estonia, and to evaluate disease disparities according to sex, age, ethnicity and education.

Design: Data from the TB Register and the Causes of Death Register were used to assess time trends in age-standardised incidence and mortality rates. The effect of sociodemographic characteristics on TB risk was modelled using Poisson regression around three population censuses. Read More

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https://www.ingentaconnect.com/content/10.5588/ijtld.18.0388
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http://dx.doi.org/10.5588/ijtld.18.0388DOI Listing
January 2019
8 Reads

Paediatric tuberculosis among the foreign-born: utility of the Canadian TB immigration medical surveillance programme.

Int J Tuberc Lung Dis 2019 Jan;23(1):105-111

Department of Paediatrics, University of Toronto, Toronto, Ontario, Division of Infectious Diseases, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: There are few data on the utility of screening paediatric immigrants for tuberculosis (TB) in low TB burden countries.

Objective: To evaluate the utility of the Canadian immigration medical examination and TB Medical Surveillance (TBMS) for detecting paediatric TB disease.

Design: A 10-year population-based retrospective cohort study of foreign-born children (ages 0-10 years) and adolescents (ages 11-17 years) immigrating to Ontario, Canada, using linked immigration and public health databases. Read More

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http://dx.doi.org/10.5588/ijtld.18.0317DOI Listing
January 2019

Long-term plasma pharmacokinetics of bedaquiline for multidrug- and extensively drug-resistant tuberculosis.

Int J Tuberc Lung Dis 2019 Jan;23(1):99-104

Université Paris Diderot, Sorbonne Paris Cité, Paris, Infection, Antimicrobiens, Modelisation, Evolution, Unité mixte de recherche 1137, Institut national de la santé et de la recherche médicale (INSERM), Paris, Service de Pharmacologie-Toxicologie, Hôpital Bichat-Claude Bernard, AP-HP, Paris.

Setting: Bedaquiline (BDQ) has been approved for the treatment of multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB). For many patients treatment is prolonged beyond the recommended 6 months. The long-term pharmacokinetics of BDQ have yet to be elucidated. Read More

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http://dx.doi.org/10.5588/ijtld.18.0042DOI Listing
January 2019
1 Read

Cigarette smoking and culture conversion in patients with susceptible and M/XDR-TB.

Int J Tuberc Lung Dis 2019 Jan;23(1):93-98

Division of Clinical Infectious Diseases, Research Centre Borstel, Borstel, German Centre for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel, International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany.

Background: Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide. Active cigarette smoking may have a significant impact on treatment responses to anti-tuberculosis treatment.

Objective: To ascertain the effect of smoking on sputum culture conversion rates following treatment initiation in patients with susceptible, multidrug-resistant and extensively drug-resistant TB (M/XDR-TB). Read More

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http://dx.doi.org/10.5588/ijtld.18.0354DOI Listing
January 2019
1 Read

Treatment outcomes, diagnostic and therapeutic impact: Xpert vs. smear. A systematic review and meta-analysis.

Int J Tuberc Lung Dis 2019 Jan;23(1):82-92

Centers for Disease Control and Prevention (CDC), Gaborone, Botswana, Division of Tuberculosis Elimination.

Background: Compared with smear microscopy, Xpert MTB/RIF has the potential to reduce delays in tuberculosis (TB) diagnosis and treatment initiation, and improve treatment outcomes. We reviewed publications comparing treatment outcomes of drug-susceptible TB patients diagnosed using Xpert vs. smear. Read More

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http://dx.doi.org/10.5588/ijtld.18.0203DOI Listing
January 2019
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Beyond 'cure' and 'treatment success': quality of life of patients with multidrug-resistant tuberculosis.

Int J Tuberc Lung Dis 2019 Jan;23(1):73-81

Médecins Sans Frontières (MSF), Mumbai, India, MSF, Operational Research Unit, Luxembourg City, Luxembourg.

Setting: Two drug-resistant tuberculosis (DR-TB) sites (MSF Clinic, Jupiter Hospital) in Mumbai, India.

Objective: To assess health-related quality of life (HRQoL) and associated factors among DR-TB patients and explore their perspectives about HRQoL.

Design: We used a mixed-methods design: a quantitative cross-sectional questionnaire (the World Health Organization's Quality of Life Brief Questionnaire [WHOQoL-BREF]); and qualitative in-depth interviews for purposively selected patients. Read More

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http://dx.doi.org/10.5588/ijtld.18.0149DOI Listing
January 2019
1 Read

Prevalence and risk factors of multidrug-resistant tuberculosis in Cubal, Angola: a prospective cohort study.

Int J Tuberc Lung Dis 2019 Jan;23(1):67-72

Infectious Disease Department, Vall d'Hebron University Hospital, Programa de Salut Internacional de l'Institut Català de la Salut Barcelona, Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Although the Republic of Angola is one of the 14 countries figuring in the three high tuberculosis (TB) burden country lists, the true multidrug-resistant TB (MDR-TB) situation is unknown.

Material And Methods: Patients aged 16 years with a diagnosis of pulmonary TB were prospectively enrolled from June 2014 to July 2015. Sputum samples were collected for culture and drug susceptibility testing in all patients, and for Xpert MTB/RIF testing in all previously treated patients and in new patients whose sputum remained smear-positive after 2 months of treatment. Read More

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http://dx.doi.org/10.5588/ijtld.18.0231DOI Listing
January 2019

Elucidating the risk factors for chronic obstructive pulmonary disease: an umbrella review of meta-analyses.

Int J Tuberc Lung Dis 2019 Jan;23(1):58-66

Departments of Hygiene and Epidemiology, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

Chronic obstructive pulmonary disease (COPD) is commonly attributed to smoking, and other potential risk factors are ignored. We aimed to critically appraise the epidemiological credibility of the risk factors for COPD that have been examined in published meta-analyses. We performed a systematic search to capture systematic reviews and meta-analyses of observational studies on environmental factors and biomarkers for risk of COPD. Read More

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https://www.ingentaconnect.com/content/10.5588/ijtld.18.0228
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http://dx.doi.org/10.5588/ijtld.18.0228DOI Listing
January 2019
10 Reads

Is there a connection between gestational diabetes mellitus, human immunodeficiency virus infection, and tuberculosis?

Int J Tuberc Lung Dis 2019 Jan;23(1):19-25

Center for Global Health, Weill Cornell Medicine, New York, New York, USA.

Pregnancy is associated with insulin resistance similar to that found in type 2 diabetes mellitus (DM). The prevalence of gestational diabetes mellitus (GDM) in key tuberculosis (TB) endemic countries, such as India and China, has been increasing rapidly in the last decade and may be higher in human immunodeficiency virus (HIV) infected women. Pregnancy is also an independent risk factor for developing active TB; however, little is known about the interaction of GDM, HIV and TB. Read More

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http://dx.doi.org/10.5588/ijtld.18.0337DOI Listing
January 2019
2 Reads

Measuring the economic burden for TB patients in the End TB Strategy and Universal Health Coverage frameworks.

Int J Tuberc Lung Dis 2019 Jan;23(1):5-11

Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.

Tuberculosis (TB) is a disease of poverty. Ensuring access to health care without the risk of financial hardship due to out-of-pocket health care expenditures (Universal Health Coverage [UHC]) is essential for providing accessible care to underprivileged populations, but this is not enough. The End TB Strategy promotes both patient-centred TB services and social protection measures, which aim to mitigate the economic hardship faced by TB patients and their households due to direct medical and non-medical expenditures, as well as to lost income. Read More

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http://dx.doi.org/10.5588/ijtld.18.0318DOI Listing
January 2019
3 Reads

Xpert at 8 years: where are we now, and what should we do next?

Authors:
D W Dowdy

Int J Tuberc Lung Dis 2019 Jan;23(1):3-4

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http://dx.doi.org/10.5588/ijtld.18.0717DOI Listing
January 2019

Patients want to live, not merely survive.

Int J Tuberc Lung Dis 2019 Jan;23(1):1-2

International Union Against Tuberculosis and Lung Disease, Paris, France, TB Service, Barts Health NHS Trust, The Royal London Hospital, London, UK, , Email:

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http://dx.doi.org/10.5588/ijtld.18.0811DOI Listing
January 2019
1 Read
2.315 Impact Factor