485,304 results match your criteria International Journal of Toxicology [Journal]


Ambient PM air pollution and cardiovascular disease prevalence: Insights from the 33 Communities Chinese Health Study.

Environ Int 2018 Dec 14;123:310-317. Epub 2018 Dec 14.

Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Backgrounds: Evidence on the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM) and cardiovascular disease (CVD) is scarce in developing countries. Moreover, few studies assessed the role of the PM (≤1. Read More

View Article
December 2018

Evidences of different meteorological patterns governing Be and Pb surface levels in the southern Iberian Peninsula.

J Environ Radioact 2018 Dec 14;198:1-10. Epub 2018 Dec 14.

Department of Integrated Sciences, Area of Applied Physics, University of Huelva, 21071, Huelva, Spain; Research Center on Natural Resources, Health and the Environment (RENSMA), University of Huelva, 21071, Huelva, Spain.

Be, Pb and PM levels in surface air have been simultaneously measured at two sampling sites in the southern Iberian Peninsula for a period of two years. Each site covers one different meteorological area of the Guadalquivir valley, from the mouth (Huelva) to the middle point (Cordoba). The objective of the present study is to analyse the spatial variability of both natural radionuclides, and to identify and characterise the meteorological patterns associated with similar and different surface concentration levels in this complex region. Read More

View Article
December 2018

Differentiation of Common Variable Immunodeficiency from Igg Deficiency.

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York. Electronic address:

Background: Common variable immunodeficiency (CVID) and IgG deficiency are two of the more prevalent primary humoral immune defects. Whereas the former is defined by consensus with criteria for quantitative and qualitative antibody defects, the latter is used to describe patients with reduced IgG, who commonly have recurrent sinopulmonary infections but do not fulfill CVID criteria. However, these patients are often given this diagnosis. Read More

View Article
December 2018

Comparison of International Systemic Adverse Reactions due to Allergen Immunotherapy.

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Section of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Royal Brompton Hospital, London, UK.

Background: Several classifications of systemic adverse reactions (SAR) during allergen immunotherapy (AIT) have been proposed but the comparison of their usefulness in daily clinical practice is lacking.

Objective: The present post hoc analysis was aimed to investigate the practicality of the most relevant international classifications proposed by the European Academy of Allergology and Clinical Immunology (EAACI), the American Academy of Asthma, Allergology and Clinical Immunology /American College of Allergy, Asthma and Immunology (AAAACI/ACAAI), and the World Allergy Organization (WAO) using data provided by the longitudinal European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI) based on daily clinical practice in 3 countries in Europe.

Methods: One hundred and nine SAR over 4363 AIT courses were classified as mild (n=78, 71. Read More

View Article
December 2018
1 Read

Household air pollution from biomass-burning cookstoves and metabolic syndrome, blood lipid concentrations, and waist circumference in Honduran women: A cross-sectional study.

Environ Res 2018 Dec 10;170:46-55. Epub 2018 Dec 10.

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA. Electronic address:

Background: Household air pollution from cooking with solid fuels affects nearly 3 billion people worldwide and is responsible for an estimated 2.5 million premature deaths and 77 million disability-adjusted life years annually. Investigating the effect of household air pollution on indicators of cardiometabolic disease, such as metabolic syndrome, can help clarify the pathways between this widespread exposure and cardiovascular diseases, which are increasing in low- and middle-income countries. Read More

View Article
December 2018

Isolation of the first New Delhi metallo-ß-lactamase-1 (NDM-1) producing, colistin resistant, Klebsiella pneumoniae sequence type ST15, from a digestive carrier in Albania, May 2018.

J Glob Antimicrob Resist 2018 Dec 14. Epub 2018 Dec 14.

Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Objectives: Carbapenemases represent a public health threat as they can spread through horizontal gene transfer and cause outbreaks. NDM-1 is a metallo-ß-lactamase that has spread rapidly in the last decade causing worldwide alarm. We aimed to describe the first isolate of NDM-1 producing and XDR Klebsiella pneumoniae in Albania, its clinical context and genetic characterization. Read More

View Article
December 2018

Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota.

Food Chem Toxicol 2018 Dec 14. Epub 2018 Dec 14.

University of Reading, Department of Food and Nutritional Sciences, PO Box 226, Whiteknights, Reading, RG6 6AP, UK.

Low/no-calorie sweeteners (LNCS) are continually under the spotlight in terms of their safety and benefits; in 2014 a study was published linking LNCS to an enhanced risk of glucose intolerance through modulation of the gut microbiota. In response, an in-depth review of the literature was undertaken to evaluate the major contributors to potential changes in the gut microbiota and their corresponding sequelae, and to determine if consuming LNCS (e.g. Read More

View Article
December 2018

Plasma and cerebrospinal fluid inflammatory cytokines in perinatal depression.

Am J Obstet Gynecol 2018 Dec 14. Epub 2018 Dec 14.

Northwestern University, Department of Psychiatry and Behavioral Sciences.

Background: While perinatal depression is one of the most common complications of pregnancy, there is an insufficient understanding of the mechanistic underpinnings of disease. While an association between peripheral inflammatory cytokines and major depressive disorder has been demonstrated, cytokines cannot freely cross the blood brain barrier and thus they give little insight into alternations in brain function. As the brain is in direct communication with the cerebrospinal fluid (CSF), assessment of inflammation in the CSF may be more directly related to the biologic markers of affective change. Read More

View Article
December 2018

Systemwide clinical assessment of functioning based on the International Classification of Functioning, Disability and Health (ICF) in China: Interrater reliability, convergent, known group, and predictive validity of the ICF Generic-6.

Arch Phys Med Rehabil 2018 Dec 14. Epub 2018 Dec 14.

Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Objective: To validate the ICF Generic-6 in daily routine clinical practice in Mainland China. Specific objectives were to a) analyse the interrater reliability, b) convergent validity, c) known group validity and d) predictive validity of the ICF Generic-6.

Design: Multi-centre prospective cohort study. Read More

View Article
December 2018

One-Year Survival and Neurologic Outcomes after Pediatric Open-Chest Cardiopulmonary Resuscitation.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.

Background: Limited data exist regarding neurobehavioral outcomes of children treated with open-chest cardiopulmonary resuscitation (CPR). Our objective was to describe neurobehavioral outcomes one year post-arrest among children who received open-chest CPR during in-hospital cardiac arrest; and explore factors associated with one-year survival and survival with good neurobehavioral outcome.

Methods: The study is a secondary analysis of the Therapeutic Hypothermia after Pediatric Cardiac Arrest In-Hospital Trial. Read More

View Article
December 2018

Outcome benefit of on-pump surgery in diabetics at 5 years - is it convincing or just predictable?

Authors:
Pradeep Narayan

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

NH Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata 700099, India. Electronic address:

View Article
December 2018

Movement Disorders in Treatable Inborn Errors of Metabolism.

Mov Disord 2018 Dec 17. Epub 2018 Dec 17.

Department of Pediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

There are several hundred single-gene disorders that we classify as inborn errors of metabolism. Inborn errors of metabolism are often rare and highly heterogeneous multisystem diseases with non-neurological and neurological manifestations, commonly with onset during childhood. Movement disorders are among the most common neurological problems in inborn errors of metabolism, but, in many cases, remain poorly defined. Read More

View Article
December 2018

The biomarker potential of cell-free microRNA from cerebrospinal fluid in Parkinsonian Syndromes.

Mov Disord 2018 Dec 17. Epub 2018 Dec 17.

Department of Neurology, Bispebjerg University Hospital, Copenhagen, Denmark.

Background: MicroRNAs are small noncoding RNAs involved in the post-transcriptional regulation of protein synthesis. Extracellular microRNAs are accessible in a stable form in biofluids.

Objectives: The aim was to identify individual microRNAs and/or subsets of microRNAs in CSF with biomarker potential and thus identify specific putative pathophysiological pathways. Read More

View Article
December 2018

Recombinant growth hormone therapy for cystic fibrosis in children and young adults.

Cochrane Database Syst Rev 2018 Dec 17;12:CD008901. Epub 2018 Dec 17.

Division of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, 630 West 168th St., New York, NY, USA, 10032.

Background: Cystic fibrosis (CF) is an inherited condition causing disease most noticeably in the lungs, digestive tract and pancreas. People with CF often have malnutrition and growth delay. Adequate nutritional supplementation does not improve growth optimally and hence an anabolic agent, recombinant human growth hormone (rhGH), has been proposed as a potential intervention. Read More

View Article
December 2018

Benefit-cost analysis of the policy of mandatory annual rabies vaccination of domestic dogs in rabies-free Japan.

PLoS One 2018 17;13(12):e0206717. Epub 2018 Dec 17.

Department of Global Agricultural Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

Japan is one of the few rabies-free countries/territories which implement the policy of mandatory vaccination of domestic dogs. In order to assess the economic efficiency of such policy in reducing the economic burden of a future canine rabies outbreak in Japan, a benefit-cost analysis (BCA) was performed using probabilistic decision tree modelling. Input data derived from simulation results of published mathematical model, field investigation conducted by the authors at prefectural governments, literature review, international or Japanese database and empirical data of rabies outbreaks in other countries/territories. Read More

View Article
December 2018

An international analysis of the price and affordability of beer.

PLoS One 2018 17;13(12):e0208831. Epub 2018 Dec 17.

Economics of Tobacco Control Project, Southern African Labour and Development Research Unit, University of Cape Town, Cape Town, South Africa.

Aims: To apply methods for measuring the affordability of beer in a large cross section of countries, and to investigate trends in affordability of beer over time.

Methods: We use the Relative Income Price (RIP), which uses per capita GDP, to measure the affordability of beer in up to 92 countries from 1990 to 2016 (69 countries were included in 1990, however the survey has since grown to include 92 countries). In addition to affordability, we also investigate trends in the price of beer. Read More

View Article
December 2018
1 Read

Peer-assisted learning after onsite, low-dose, high-frequency training and practice on simulators to prevent and treat postpartum hemorrhage and neonatal asphyxia: A pragmatic trial in 12 districts in Uganda.

PLoS One 2018 17;13(12):e0207909. Epub 2018 Dec 17.

Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

An urgent need exists to improve and maintain intrapartum skills of providers in sub-Saharan Africa. Peer-assisted learning may address this need, but few rigorous evaluations have been conducted in real-world settings. A pragmatic, cluster-randomized trial in 12 Ugandan districts provided facility-based, team training for prevention and management of postpartum hemorrhage and birth asphyxia at 125 facilities. Read More

View Article
December 2018

Level and determinants of birth preparedness and complication readiness among pregnant women: A cross sectional study in a rural area in Bangladesh.

PLoS One 2018 17;13(12):e0209076. Epub 2018 Dec 17.

International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b); Mohakhali, Dhaka, Bangladesh.

Background: Increasing the level of birth preparedness and complication readiness (BP/CR) is one of the key interventions to promote optimal utilization of skilled maternal health services. It is therefore essential to determine the women's ability to recognize the danger signs and the level of BP/CR. This information can be used to design more effective health interventions. Read More

View Article
December 2018

Angiopoietin-2 promotes osteogenic differentiation of thoracic ligamentum flavum cells via modulating the Notch signaling pathway.

PLoS One 2018 17;13(12):e0209300. Epub 2018 Dec 17.

Central Laboratory, Peking University International Hospital, Beijing, China.

Thoracic ossification of the ligamentum flavum (TOLF) is heterotopic ossification of spinal ligaments, which may cause serious thoracic spinal canal stenosis and myelopathy. However, the underlying etiology remains inadequately understood. In this study, the ossification patterns of TOLF were analyzed by micro-computer tomography (micro-CT). Read More

View Article
December 2018

Protective versus pathologic pre-exposure cytokine profiles in dengue virus infection.

PLoS Negl Trop Dis 2018 Dec 17;12(12):e0006975. Epub 2018 Dec 17.

Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island, United States of America.

Background: Hyperendemic circulation of all four types of dengue virus (DENV-1-4) has expanded globally, fueling concern for increased incidence of severe dengue. While the majority of DENV infections are subclinical, epidemiologic studies suggest that type-cross-reactive immunity can influence disease outcome in subsequent infections. The mechanisms controlling these differential clinical outcomes remain poorly defined. Read More

View Article
December 2018

Health seeking for chronic lung disease in central Malawi: Adapting existing models using insights from a qualitative study.

PLoS One 2018 17;13(12):e0208188. Epub 2018 Dec 17.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.

Background: Chronic lung diseases contribute to the growing non-communicable disease (NCD) burden and are increasing, particularly in many low and middle-income countries (LMIC) in sub-Saharan African. Early engagement with health systems in chronic lung disease management is critical to maintain quality of life and prevent further damage. Our study sought to understand health seeking behaviour in relation to chronic lung disease and TB in a rural district in Malawi. Read More

View Article
December 2018
1 Read

Genome-wide association mapping of spot blotch resistance in wheat association mapping initiative (WAMI) panel of spring wheat (Triticum aestivum L.).

PLoS One 2018 17;13(12):e0208196. Epub 2018 Dec 17.

International Maize and Wheat Improvement Center (CIMMYT), DPS Marg, New Delhi, India.

Spot blotch (SB) caused by Bipolaris sorokiniana, is one of the most important diseases of wheat in the eastern part of south Asia causing considerable yield loss to the wheat crop. There is an urgent need to identify genetic loci closely associated with resistance to this pathogen for developing resistant cultivars. Hence, genomic regions responsible for SB resistance were searched using a wheat association mapping initiative (WAMI) panel involving 287 spring wheat genotypes of different origin. Read More

View Article
December 2018
1 Read

Understanding and predicting the longitudinal course of dementia.

Curr Opin Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

Centre for Dementia Prevention, University of Edinburgh, Edinburgh, UK.

Purpose Of Review: To date, most research in dementia has focused either on the identification of dementia risk prediction or on understanding changes and predictors experienced by individuals before diagnosis. Despite little is known about how individuals change after dementia diagnosis, there is agreement that changes occur over different time scales and are multidomain. In this study, we present an overview of the literature regarding the longitudinal course of dementia. Read More

View Article
December 2018
1 Read

Exploring the Pathways Revealed by International Sepsis Benchmarking.

Authors:
Allan J Walkey

Crit Care Med 2019 Jan;47(1):135-137

The Pulmonary Center, and Evans Center for Implementation and Improvement Sciences, Department of Medicine, Boston University School of Medicine; and Department of Health Law, Policy and Management, Boston University School of Public Health, Boston, MA.

View Article
January 2019

In Reply: Encouraging a Bare Minimum While Striving for the Gold Standard: A Response to the Updated WHO-WFSA Guidelines.

Anesth Analg 2019 Jan;128(1):e13-e14

Department of Anesthesia & Perioperative Care University of California San Francisco, San Francisco, California University of Otago, Christchurch Hospital, Christchurch, New Zealand Services Organization and Clinical Interventions Unit (SCI), Service Delivery and Safety Department (SDS), Health Systems and Innovation (HIS), World Health Organization, Switzerland Department of Anaesthesiology, University of Auckland Department of Anaesthesia, Auckland City Hospital, Auckland, New Zealand.

View Article
January 2019

Mechanical Dilation Using Nylon Monofilament Aids Multisite Lymphaticovenous Anastomosis Through Improving the Quality of Anastomosis.

Ann Plast Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Lymphaticovenous anastomosis (LVA) is now a common treatment for lymphedema. It is important to create as many bypasses as possible to maximize the efficacy of LVA. We have developed a method whereby nylon monofilaments are placed inside the vessel lumen to act as dilators. Read More

View Article
December 2018

From A to D: A Unique Case Report of Recovery after Longitudinal Myelitis Related to Lupus.

Am J Phys Med Rehabil 2018 Dec 14. Epub 2018 Dec 14.

HealthPartners Neuroscience Center, St. Paul, MN, USA.

Longitudinal myelitis secondary to an acute flare of systemic lupus erythematosus (SLE) has been reported in the literature. There have been few published cases of complete functional recovery in patients with systemic lupus erythematosus related longitudinal myelitis (SLE-LM). Of those cases, none have described in detail the rehabilitation course of treatment. Read More

View Article
December 2018
1 Read

Skin Integrity and Infection Prevention Las Vegas: transform uncertainty into quality wound healing.

Authors:

J Wound Care 2018 Dec;27(12):860-861

The 4th International Skin Integrity and Infection Prevention conference, in hosted by the Journal of Wound Care and the University of Huddersfield, was held in Las Vegas. The last in our series of reports, which describe the key points discussed at the sponsored symposia, looked at wound bed preparation, concentrating on debriding a wound using a surfactant gel when sharp debridement is not an option. Read More

View Article
December 2018
1 Read

Skin Integrity and Infection Prevention Las Vegas: continuous delivery of oxygen enhances closure of diabetic foot ulcers.

Authors:

J Wound Care 2018 Dec;27(12):856-857

The 4th International Skin Integrity and Infection Prevention conference, hosted by the Journal of Wound Care and the University of Huddersfield in Las Vegas, included a series of sponsored symposia. This is the third in our series of reports on the key points of the symposia, which outlined the effects of hypoxia on wound healing, and how reduced oxygen levels can lead to chronic, non-healing wounds. The speaker, Mark Niederauer, explained what can be done to combat low oxygen levels using a new continuous diffusion of oxygen (CDO) device. Read More

View Article
December 2018
1 Read

Behcet's Disease in Iran; Analysis of 7641 Cases.

Mod Rheumatol 2018 Dec 17:1-21. Epub 2018 Dec 17.

a Behcet's Disease Unit, Rheumatology Research Center , Shariati Hospital, Tehran University of Medical Sciences , Tehran , Iran.

Objective: To analyze Behcet's Disease (BD) in Iran, from 1975 to 2018, and compare to 35 large/small reports from other countries.

Methods: Patients from all over Iran, when suspected, were sent to the BD Unit. The diagnosis was done by expert opinion. Read More

View Article
December 2018
1 Read

Design and synthesis of mixed micellar system for enhanced anticancer efficacy of Paclitaxel through its co-delivery with Naringin.

Drug Dev Ind Pharm 2018 Dec 17:1-40. Epub 2018 Dec 17.

a H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences , Karachi University , Karachi , 74200 , Pakistan.

Emergence of multidrug resistance (MDR) has limited the success of chemotherapeutic agents. Reversal of drugs efflux systems through combination therapy has got wider attention for increasing anticancer drugs efficacy. This study aims at co-encapsulation of Paclitaxel with Naringin in mixed polymeric micelles for enhanced anticancer activity of the drug. Read More

View Article
December 2018

Improvement in Functional Outcome Scores Despite Persistent Pain With 1 Year of Nonsurgical Management for Acetabular Labral Tears With or Without Femoroacetabular Impingement.

Am J Sports Med 2018 Dec 17:363546518814484. Epub 2018 Dec 17.

Department of Orthopaedic Surgery, Mass General Hospital, Boston, Massachusetts, USA.

Background:: Acetabular labral tears are increasingly recognized as a source of hip pain in a younger active population. Given the significant focus on surgical intervention, there has been limited investigation on the nonsurgical management and natural history of such injuries.

Hypothesis:: Patients undergoing nonsurgical treatment for symptomatic acetabular labral tears experience functional improvement based on patient-reported outcome measures over the course of 1 year. Read More

View Article
December 2018

Low Residual Carrier Concentration and High Mobility in 2D Semiconducting BiOSe.

Nano Lett 2018 Dec 17. Epub 2018 Dec 17.

Center for Nanochemistry, Beijing Science and Engineering Center for Nanocarbons, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering , Peking University , Beijing 100871 , P. R. China.

The air-stable and high-mobility two-dimensional (2D) BiOSe semiconductor has emerged as a promising alternative that is complementary to graphene, MoS, and black phosphorus for next-generation digital applications. However, the room-temperature residual charge carrier concentration of 2D BiOSe nanoplates synthesized so far is as high as about 10-10 cm, which results in a poor electrostatic gate control and unsuitable threshold voltage, detrimental to the fabrication of high-performance low-power devices. Here, we first present a facile approach for synthesizing 2D BiOSe single crystals with ultralow carrier concentration of ∼10 cm and high Hall mobility up to 410 cm V s simultaneously at room temperature. Read More

View Article
December 2018
1 Read

Chromosome analysis using benchtop flow analysers and high speed cell sorters.

Cytometry A 2018 Dec 17. Epub 2018 Dec 17.

Cytometry Core Facility, Wellcome Sanger Institute, Cambridge, CB10 1SA, UK.

The use of the DNA dyes Hoechst (HO) and chromomycin A3 (CA3) has become the preferred combination for the bivariate analysis of chromosomes from both human and animals. This analysis requires a flow cytometer equipped with lasers of specific wavelength and of higher power than is typical on a conventional bench top flow cytometer. In this study, we have investigated the resolution of chromosome peaks in a human cell line with normal flow karyotype using different combinations of DNA dyes on a number of flow cytometers available in a flow cytometry core facility. Read More

View Article
December 2018

Practical Application of H Benchtop NMR Spectroscopy for the Characterization of a Non-Aqueous Phase Liquid from a Contaminated Environment.

Magn Reson Chem 2018 Dec 17. Epub 2018 Dec 17.

School of Environmental Sciences, University of Guelph, Guelph, On, Canada, N1G 2W1.

Non-Aqueous Phase Liquids (NAPLs) located at the surface of the water table and/or below the water table are often a significant source for groundwater contamination near current or former commercial/industrial facilities. Due to the complex and long history of many industrial sites, these NAPLs often contain a complex mixture of contaminants and as such can be difficult to fully characterize using conventional analytical methods. Remediation and risk assessment activities at sites containing NAPLs may, subsequently, be hindered as the contamination profile may not be fully understood. Read More

View Article
December 2018

A meta-analysis of the effect of microRNA-34a on the progression and prognosis of gastric cancer.

Authors:
Z Li Z-M Liu B-H Xu

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8281-8287

Department of Interventional Therapy, Harrison International Peace Hospital, Hengshui, Hebei, China.

Objective: To explore the value of microRNA-34a (miR-34a) as a diagnostic biomarker of gastric cancer development and prognosis.

Materials And Methods: PubMed, Web of Science, Embase, CNKI, Wanfang Database and Gene Expression Omnibus (GEO) were searched according to the key words for the literature about the expression of microRNA-34a in the serum or tissues of gastric cancer patients. The data of gene expression were extracted and the data were analyzed by Stata 14. Read More

View Article
December 2018

Valid publication of the names Caecibacterium and Caecibacterium sporoformans.

Int J Syst Evol Microbiol 2018 Dec 17. Epub 2018 Dec 17.

7​Boehringer Ingelheim Veterinary Research Center, Bemeroder Strasse 31, 30559 Hannover, Germany.

Descriptions of the genus Caecibacterium and its proposed type species Caecibacterium sporoformans were published in the IJSEM by Onrust et al. (Int J Syst Evol Microbiol 2017;67:4589-4594). The type strain was deposited as LMG 27730 and DSM 26959. Read More

View Article
December 2018

Staying on your feet: the effectiveness of posture and handles in counteracting balance perturbation.

Ergonomics 2018 Dec 17:1-27. Epub 2018 Dec 17.

a Laboratory for Neuromechanics and Biorobotics, Department of Automation, Biocybernetics and Robotics , Jožef Stefan Institute , Ljubljana , Slovenia.

Stairways, public transport, and inclined walkways are often considered as sites with higher likelihood of falls due to a sudden loss of balance. Such sites are usually marked with warning signs, equipped with non-slip surfaces and handles or handrails to avert or decrease this likelihood. Especially handles are supposed to provide additional support in cases of a sudden loss of balance. Read More

View Article
December 2018

The fascinating biology behind phage display: Filamentous Phage Assembly.

Mol Microbiol 2018 Dec 17. Epub 2018 Dec 17.

Zhejiang University-Edinburgh University (ZJU-UoE) Institute, Zhejiang University School of Medicine, International Campus, Zhejiang University, 718 East Haizhou Road, Haining, Zhejiang, 314400, P. R. China.

With the recently awarded Nobel Prize to the inventor of Phage Display, George Smith, the technique has once more gained attention. However, one should not forget about the biology behind the method. Almost always ignored is how the structure of this bacterial virus is assembled. Read More

View Article
December 2018

Care prior to and during subsequent pregnancies following stillbirth for improving outcomes.

Cochrane Database Syst Rev 2018 Dec 17;12:CD012203. Epub 2018 Dec 17.

NHMRC Centre of Research Excellence in Stillbirth, Mater Research Institute - The University of Queensland (MRI-UQ), Level 3 Aubigny Place, Mater Health Services, Brisbane, Queensland, Australia, 4101.

Background: Stillbirth affects at least 2.6 million families worldwide every year and has enduring consequences for parents and health services. Parents entering a subsequent pregnancy following stillbirth face a risk of stillbirth recurrence, alongside increased risks of other adverse pregnancy outcomes and psychosocial challenges. Read More

View Article
December 2018

Workplace interventions for reducing sitting at work.

Cochrane Database Syst Rev 2018 Dec 17;12:CD010912. Epub 2018 Dec 17.

Institute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia.

Background: A large number of people are employed in sedentary occupations. Physical inactivity and excessive sitting at workplaces have been linked to increased risk of cardiovascular disease, obesity, and all-cause mortality.

Objectives: To evaluate the effectiveness of workplace interventions to reduce sitting at work compared to no intervention or alternative interventions. Read More

View Article
December 2018

Surface charge tunable catanionic vesicles based on serine-derived surfactants as efficient nanocarriers for the delivery of the anticancer drug doxorubicin.

Nanoscale 2018 Dec 17. Epub 2018 Dec 17.

Department of Nanophotonics, Ultrafast Bio- and Nanophotonics group, INL-International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal.

Self-assembled vesicles composed of amino acid-based cationic/anionic surfactant mixtures show promise as novel effective drug nanocarriers. Here, we report the in vitro performance of vesicles based on cationic (16Ser) and anionic (8-8Ser) serine-based surfactants using a cancer cell model for the delivery of the anticancer drug doxorubicin (DOX). This catanionic mixture yields both negatively (0. Read More

View Article
December 2018

Protective effect of Selenium-L-methionine on radiation-induced acute pneumonitis and lung fibrosis in rat.

Curr Clin Pharmacol 2018 Dec 13. Epub 2018 Dec 13.

Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences (International Campus), Tehran. Iran.

Background: In this study, we aimed to detect the changes in the level of interleukin (IL)-4 and IL-13 cytokines and their downstream genes including interleukin-13 receptor subunit alpha-2 (IL13Ra2), interleukin-4 receptor subunit alpha-1 (IL4Ra1), dual oxidase 1 (DUOX1) and dual oxidase 2 (DUOX2). The protective effects of Selenium-L-methionine on radiation-induced histopathological damages and changes in the level of these cytokines and genes were detected.

Methods: Four groups of 20 rats (5 rats in each) namely control; Selenium-L-methionine, radiation; and radiation plus Selenium-L-methionine, were used in this study. Read More

View Article
December 2018
1 Read

Sports mega-event legacies and adult physical activity: A systematic literature review and research agenda.

Eur J Sport Sci 2018 Dec 15:1-15. Epub 2018 Dec 15.

a Department of Health and Physical Education , International Christian University , Mitaka , Japan.

Sports mega-events, such as the Olympic and Paralympic Games, have the potential to inspire increases in population physical activity, yet investigations concerning such legacy outcomes have been inconclusive. This may be due to research design limitations or inconsistent leveraging of potential hosting benefits by event organizers. This systematic review aims to identify current knowledge about the capacity of sports mega-events to inspire increases in physical activity participation among adult populations and develop a research agenda to guide future legacy evaluations. Read More

View Article
December 2018

The association of bike fitting with injury, comfort, and pain during cycling: An international retrospective survey.

Eur J Sport Sci 2018 Dec 15:1-8. Epub 2018 Dec 15.

e Applied Neuromechanics Group, Laboratory of Neuromechanics , Federal University of Pampa , Uruguaiana , Brazil.

Although bike fitting is recommended to help reduce injury risk, little empirical evidence exists to indicate an association between bike fitting and injury incidence. The aim of the study was to determine the effect of bike fitting on self-reported injury, comfort, and pain while cycling from a worldwide survey of cyclists. A total of 849 cyclists completed an online questionnaire between February and October 2016. Read More

View Article
December 2018

Treatment of tumor-like lesions in the femoral neck using free nonvascularized fibular autografts in pediatric patients before epiphyseal closure.

J Int Med Res 2018 Dec 16:300060518813510. Epub 2018 Dec 16.

2 Postdoctoral Innovation Practice Base, The Ninth Affiliated Hospital of Guangxi Medical University, Beihai, China.

Objectives: Surgical resection of benign bone tumors and tumor-like lesions at the femoral neck presents a difficult reconstructive challenge. However, the safety and efficacy of free nonvascularized fibular autografts (FNFAs) in the treatment of femoral neck tumor-like lesions before epiphyseal closure in young patients remain unknown.

Methods: Sixteen pediatric patients who had not yet undergone epiphyseal closure were treated with FNFAs after resection of tumor-like lesions in the femoral neck from August 2012 to September 2016. Read More

View Article
December 2018

"A child may be tall but also stunted." Conceptualization of and meanings attached to childhood height and short stature in rural Tanzania.

Matern Child Nutr 2018 Dec 16:e12769. Epub 2018 Dec 16.

Population Research Centre, Faculty of Spatial Sciences, University of Groningen, The Netherlands.

Stunting affects large numbers of under-fives in Tanzania. But do caretakers of under-fives recognize height as a marker of child growth? What meanings do they attach to linear growth? An ethnographic study using cultural schemas theory was conducted in a rural community in Southeastern Tanzania to investigate caregivers' conceptualizations of child height in relation to growth and the meanings attached to short stature. Data for the study was collected through 19 focus group discussions, 30 in-depth interviews, and five key informant interviews with caregivers of under-fives, including mothers, fathers, elderly women, and community health workers. Read More

View Article
December 2018
1 Read

Modification of the dialysate port of plasma separators for safe blood purification in Japan.

Ther Apher Dial 2018 Dec 16. Epub 2018 Dec 16.

Tokyo Next Clinic, Tokyo, Japan.

A fatal mix-up of a hemofilter with a plasma separator occurred in 2011. The close resemblance between the two blood purification columns commonly used in Japan posed a fundamental risk for such mix-ups. Both the in-hospital case investigation committee and the relevant academic societies have independently proposed the modifications of the dialysate port (D port) of the plasma separator to avoid this type of misuse. Read More

View Article
December 2018

Developing a revised definition of the Bobath concept.

Physiother Res Int 2018 Dec 16:e1762. Epub 2018 Dec 16.

Department of Physical Therapy, University of Toronto, Toronto, Ontario, Canada.

Objective: This study was developed as a consensus-building exercise within the International Bobath Instructors Training Association (IBITA) to develop a revised definition of the Bobath concept.

Methods: A three-phase design utilizing (a) focus groups, (b) survey methods, and, (c) real-time Delphi. This paper details Phase 1 and 2. Read More

View Article
December 2018

Quality assessment of Ki67 staining using cell line proliferation index and stain intensity features.

Cytometry A 2018 Dec 17. Epub 2018 Dec 17.

Department of Health Science and Technology, Aalborg University, Fredrik Bajersvej 7D2, 9220, Aalborg, Denmark.

Breast cancer is the most frequent cancer among women worldwide. Ki67 can be used as an immunohistochemical pseudo marker for cell proliferation to determine how aggressive the cancer is and thereby the treatment of the patient. No standard Ki67 staining protocol exists, resulting in inter-laboratory stain variability. Read More

View Article
December 2018