1,971 results match your criteria International Journal of Stroke [Journal]


Management of oral anticoagulation after intracerebral hemorrhage.

Int J Stroke 2019 Feb 14:1747493019828555. Epub 2019 Feb 14.

Department of Neurology, University Hospital Erlangen, Erlangen, Germany.

Background: The most recent years have significantly expanded knowledge regarding risks and benefits of resuming oral anticoagulation (OAC) after intracerebral hemorrhage (ICH). No randomized data is yet available, though several large observational studies and meta-analyses have investigated the impact of resuming OAC on thromboembolic versus hemorrhagic complications in these high-risk patients after ICH.

Aims: The present review will summarize the most important studies conducted over the last years and will focus on relevant factors help guiding on decision-making on whether to start OAC after ICH. Read More

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http://dx.doi.org/10.1177/1747493019828555DOI Listing
February 2019

Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis.

Int J Stroke 2019 Feb 14:1747493019830321. Epub 2019 Feb 14.

1 Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.

Background: Perivascular spaces, visible on brain magnetic resonance imaging, are thought to be associated with small vessel disease, neuroinflammation, and to be important for cerebral hemodynamics and interstitial fluid drainage.

Aims: To benchmark current knowledge on perivascular spaces associations with risk factors, neurological disorders, and neuroimaging lesions, using systematic review and meta-analysis.

Summary Of Review: We searched three databases for perivascular spaces publications, calculated odds ratios with 95% confidence interval and performed meta-analyses to assess adjusted associations with perivascular spaces. Read More

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http://dx.doi.org/10.1177/1747493019830321DOI Listing
February 2019

The effect of cerebellar transcranial direct current stimulation to improve standing balance performance early post-stroke, study protocol of a randomized controlled trial.

Int J Stroke 2019 Feb 13:1747493019830312. Epub 2019 Feb 13.

1 Department of Rehabilitation Medicine, Amsterdam Neurosciences and Amsterdam Movement Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Rationale: Restoration of adequate standing balance after stroke is of major importance for functional recovery. POstural feedback ThErapy combined with Non-invasive TranscranIAL direct current stimulation (tDCS) in patients with stroke (POTENTIAL) aims to establish if cerebellar tDCS has added value in improving standing balance performance early post-stroke.

Methods: Forty-six patients with a first-ever ischemic stroke will be enrolled in this double-blind controlled trial within five weeks post-stroke. Read More

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http://dx.doi.org/10.1177/1747493019830312DOI Listing
February 2019

Cost-utility analysis of mechanical thrombectomy between 6 and 24 hours in acute ischemic stroke.

Int J Stroke 2019 Feb 13:1747493019830587. Epub 2019 Feb 13.

2 Imaging Department, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK.

Background: Recently, two randomized controlled trials demonstrated the benefit of mechanical thrombectomy performed between 6 and 24 h in acute ischemic stroke. The current economic evidence is supporting the intervention only within 6 h, but extended thrombectomy treatment times may result in better long-term outcomes for a larger cohort of patients.

Aims: We compared the cost-utility of mechanical thrombectomy in addition to medical treatment versus medical treatment alone performed beyond 6 h from stroke onset in the UK National Health Service (NHS). Read More

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http://dx.doi.org/10.1177/1747493019830587DOI Listing
February 2019

Targets for improving dispatcher identification of acute stroke.

Int J Stroke 2019 Feb 13:1747493019830315. Epub 2019 Feb 13.

1 Neurology, Clinical Neurosciences, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Accurate identification of acute stroke by Emergency Medical Dispatchers (EMD) is essential for timely and purposeful deployment of Emergency Medical Services (EMS), and a prerequisite for operating mobile stroke units. However, precision of EMD stroke recognition is currently modest.

Aims: We sought to identify targets for improving dispatcher stroke identification. Read More

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http://dx.doi.org/10.1177/1747493019830315DOI Listing
February 2019
1 Read

Location-specific differences in hematoma volume predict outcomes in patients with spontaneous intracerebral hemorrhage.

Int J Stroke 2019 Feb 12:1747493019830589. Epub 2019 Feb 12.

1 Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Background And Objective: Functional outcome after spontaneous intracerebral hemorrhage (ICH) may vary depending on hematoma volume and location. We assessed the interaction between hematoma volume and location, and modified the original ICH score to include such an interaction.

Methods: Consecutive ICH patients were enrolled in the Intracerebral Hemorrhage Outcomes Project from 2009 to 2017. Read More

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http://dx.doi.org/10.1177/1747493019830589DOI Listing
February 2019

The Acute Stroke or Transient Ischemic Attack Treated with Ticagrelor and Aspirin for Prevention of Stroke and Death (THALES) trial: Rationale and design.

Int J Stroke 2019 Feb 12:1747493019830307. Epub 2019 Feb 12.

7 Department of Neurology, Beijing Tiantan Hospital, Beijing, China.

Rationale: In patients with acute cerebral ischemia, the rate of stroke, myocardial infarction, or death during 90 days was reported to be non-significantly lower with ticagrelor compared with aspirin, with no increase in major hemorrhage. Dual antiplatelet therapy may be more effective in this setting.

Aim: To investigate whether ticagrelor combined with aspirin are superior to aspirin alone in preventing stroke or death in patients with non-severe, non-cardioembolic ischemic stroke or high-risk transient ischemic attack. Read More

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http://dx.doi.org/10.1177/1747493019830307DOI Listing
February 2019
1 Read

Utility-weighted modified Rankin Scale: Still too crude to be a truly patient-centric primary outcome measure?

Int J Stroke 2019 Feb 12:1747493019830583. Epub 2019 Feb 12.

1 NHMRC Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.

Background: The utility-weighted modified Rankin Scale (UW-mRS) is an outcome measure recently proposed to improve statistical efficiency and interpretability of the mRS. Statistical properties of the UW-mRS have been well investigated, but construct validity has yet to be established.

Aims: To investigate the construct validity of the UW-mRS as a primary outcome measure by assessing variability in utility values within and between mRS categories, over time post-stroke, and by different derivation methods. Read More

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http://dx.doi.org/10.1177/1747493019830583DOI Listing
February 2019
1 Read

Cerebral microbleeds: Beyond the macroscope.

Int J Stroke 2019 Feb 12:1747493019830594. Epub 2019 Feb 12.

1 Department of Medical Pharmacology, Univ Lille, Inserm U1171-Degenerative and Vascular Cognitive Disorders, CHU Lille, Lille, France.

While being increasingly recognized in clinical routine, brain microbleeds remain a puzzling finding for physicians. These small dot-like lesions are thought to be old perivascular collections of hemosiderin deposits. They can be found in different neurological settings such as cerebrovascular or neurodegenerative diseases. Read More

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February 2019
1 Read

Burden of large vessel occlusion stroke and the service gap of thrombectomy: A population-based study using a territory-wide public hospital system registry.

Int J Stroke 2019 Feb 11:1747493019830585. Epub 2019 Feb 11.

1 Division of Neurosurgery, Department of Surgery, The University of Hong Kong, Hong Kong.

Background: Ischemic stroke due to large vessel occlusion can be effectively treated with thrombectomy but access to this treatment is limited in many parts of the world. Local incidence of large vessel occlusion is critical in determining the development of thrombectomy service, but reliable data from Asian countries are lacking.

Aims: We performed a population-based study to estimate the burden of large vessel occlusion and the service gap for thrombectomy in Hong Kong. Read More

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February 2019
2 Reads

Transient ischemic attack: Incidence and early risk of stroke in northern Portugal from 1998-2000 to 2009-2011.

Int J Stroke 2019 Feb 8:1747493019830322. Epub 2019 Feb 8.

1 Serviço de Neurologia, Hospital Santo António-Centro Hospitalar do Porto, Porto, Portugal.

Objective: A decline in TIA incidence would be expected mirroring stroke trends, but patient's awareness of symptoms/signs, improved diagnostic procedures and changes in severity of vascular disease may raise TIA incidence. We aimed to estimate changes in TIA incidence and 30-day stroke risk in Portugal.

Methods: Data from two prospective community-based registers of first-ever TIA in 104,700 (1998-2000) and 118,232 (2009-2011) persons were collected using comprehensive case ascertainment methods. Read More

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http://dx.doi.org/10.1177/1747493019830322DOI Listing
February 2019

Diagnosis and management of carotid free-floating thrombus: A systematic literature review.

Int J Stroke 2019 Feb 6:1747493019828554. Epub 2019 Feb 6.

1 Department of Clinical Neurological Sciences, Division of Neurology, University of Western Ontario, London, Canada.

Background: There is no consensus regarding the management of carotid free-floating thrombi in patients with acute ischemic stroke and transient ischemic attack.

Aims: This systematic review aims to (1) describe the current imaging methods for diagnosis of carotid free-floating thrombi and its associated risk factors, (2) estimate the proportion of carotid free-floating thrombi diagnosed in stroke patients, (3) estimate the proportion of carotid free-floating thrombi patients treated medically and surgically, and (4) evaluate 30-day outcomes.

Methods: We searched MEDLINE, EMBASE, and manually for references reporting carotid free-floating thrombi from 1960 until June 2017. Read More

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http://dx.doi.org/10.1177/1747493019828554DOI Listing
February 2019
2 Reads

New opportunities to optimize antithrombotic therapy for secondary stroke prevention.

Int J Stroke 2019 Feb 6:1747493019828548. Epub 2019 Feb 6.

Department of Neurology, UCSF, San Francisco, USA.

Stroke symptoms can be unsettling, even when symptoms resolve, but focusing on stroke prevention can be empowering provided that effective interventions for appropriate patient populations are available. Current options include interventions for symptomatic carotid artery stenosis, anticoagulation for atrial fibrillation, high-dose statins, new oral anticoagulants, new developments in atrial fibrillation detection, and new therapeutics are in development. For antiplatelet therapy, aspirin monotherapy is effective but dual antiplatelet therapy with the combination of aspirin and clopidogrel increases hemorrhage risks over the long term that outweigh potential benefits. Read More

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http://dx.doi.org/10.1177/1747493019828548DOI Listing
February 2019
2 Reads

Impact of prehospital stroke code in a public center in Paraguay: A pilot study.

Int J Stroke 2019 Feb 1:1747493019828643. Epub 2019 Feb 1.

Stroke Unit, Emergency Department, Hospital de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Asunción (F.C.M.-U.N.A.), San Lorenzo, Paraguay.

Prehospital stroke code activation results in reduced pre- and in-hospital delays and triage and transport of stroke patients to the right centers. In Paraguay, data about acute reper fusion treatment are not available. Recently, a pilot prehospital stroke code program was implemented in the country in November 2016. Read More

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February 2019

Regional differences in ischemic stroke in India (north vs. south).

Int J Stroke 2019 Jan 31:1747493019828538. Epub 2019 Jan 31.

6 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Background: India is a large country with geographically diverse populations and varying risk factors. Identification of regional differences can improve healthcare policy decisions.

Aim: To study regional differences in stroke between North and South India. Read More

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January 2019
3 Reads

High in-hospital blood pressure variability and severe disability or death in primary intracerebral hemorrhage patients.

Int J Stroke 2019 Jan 25:1747493019827763. Epub 2019 Jan 25.

1 Department of Neurology and Institute for Stroke and Cerebrovascular Diseases at McGovern Medical School, University of Texas Health, Houston, TX, USA.

Objective: To quantify in-hospital systolic blood pressure variability among patients with intracerebral hemorrhage, determine the association between high systolic blood pressure variability (HSBPV) and 90-day severe disability or death, and examine the association between pre-hospital factors and HSBPV.

Methods: Adult, radiologically confirmed, intracerebral hemorrhage patients enrolled in a multi-site cohort were included. Using a semi-automated algorithm, systolic blood pressure values recorded from routine non-invasive systolic blood pressure monitoring in critical and acute care settings were extracted for the duration of hospitalization. Read More

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http://dx.doi.org/10.1177/1747493019827763DOI Listing
January 2019
1 Read

The potential of m-Health-based interventions to improve medication literacy and adherence in non-communicable diseases in Pakistan.

Int J Stroke 2019 Jan 25:1747493019827762. Epub 2019 Jan 25.

6 Michael E. DeBakey Veterans Affairs Medical Center, Houston, USA.

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http://dx.doi.org/10.1177/1747493019827762DOI Listing
January 2019
3 Reads

Anticoagulation in patients with Embolic Stroke of Unknown Source.

Authors:
J David Spence

Int J Stroke 2019 Jan 15:1747493019826363. Epub 2019 Jan 15.

Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Canada.

When warfarin was the mainstay of anticoagulation for the prevention of cardioembolic stroke, the paradigm was essentially "we mustn't anticoagulate anyone unless we prove that the stroke was cardioembolic." Now that direct-acting oral anticoagulants are available, the paradigm should change. The risk of stroke is highest soon after the initial event, particularly in patients with more than one infarction. Read More

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January 2019
2 Reads

Advanced clinical education for stroke physicians in China: The ACTION and SCA models.

Int J Stroke 2019 Jan 11:1747493018816515. Epub 2019 Jan 11.

2 Melbourne Brain Centre at the Royal Melbourne Hospital and University of Melbourne, VIC, Australia.

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http://dx.doi.org/10.1177/1747493018816515DOI Listing
January 2019
5 Reads

Contemporary prognosis of transient ischemic attack patients: A systematic review and meta-analysis.

Int J Stroke 2019 Jan 11:1747493018823568. Epub 2019 Jan 11.

2 Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia.

Background: Transient ischemic attacks are common and place patients at risk of subsequent stroke. The 2007 EXPRESS and SOS-TIA studies demonstrated the efficacy of rapid treatment initiation. We hypothesized that with these findings having informed subsequent transient ischemic attacks management protocols, transient ischemic attacks prognosis in contemporary (2008 and later) patient cohorts would be more favorable than in historical cohorts. Read More

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http://dx.doi.org/10.1177/1747493018823568DOI Listing
January 2019
5 Reads

Functional and emotional outcomes after transient ischemic attack: A 12-month prospective controlled cohort study.

Int J Stroke 2019 Jan 11:1747493018823158. Epub 2019 Jan 11.

5 Quadram Institute Bioscience, Norwich Research Park, Norwich, UK.

Background: Symptoms of transient ischemic attack are believed to fully resolve within 24 h of onset. Emerging evidence suggests that there may be prolonged functional and psychological impact, although studies have not been able to robustly identify whether these are the effect of transient ischemic attack or changes usually associated with ageing. We describe trajectories of disability and risk of anxiety and depression among patients seen at transient ischemic attack clinics over 12 months, compared to healthy controls. Read More

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http://dx.doi.org/10.1177/1747493018823158DOI Listing
January 2019

The ongoing debate on anesthetic strategies during endovascular treatment: Can local anesthesia solve the puzzle?

Int J Stroke 2019 Jan 9:1747493018823571. Epub 2019 Jan 9.

4 Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1177/1747493018823571DOI Listing
January 2019

The International comparison of Systems of care and patient outcomes In minor Stroke and Tia (InSIST) study: A community-based cohort study.

Int J Stroke 2019 Jan 4:1747493018799983. Epub 2019 Jan 4.

13 Discipline of General Practice, University of Newcastle, Newcastle, Australia.

Rationale: Rapid response by health-care systems for transient ischemic attack and minor stroke (TIA/mS) is recommended to maximize the impact of secondary prevention strategies. The applicability of this evidence to Australian non-hospital-based TIA/mS management is uncertain.

Aims: Within an Australian community setting we seek to document processes of care, establish determinants of access to care, establish attack rates and determinants of recurrent vascular events and other clinical outcomes, establish the performance of ABC2-risk stratification, and compare the processes of care and outcomes to those in the UK and New Zealand for TIA/mS. Read More

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http://dx.doi.org/10.1177/1747493018799983DOI Listing
January 2019
1 Read

Statistical Analysis Plan for EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND) trial.

Int J Stroke 2018 Dec 7:1747493018816101. Epub 2018 Dec 7.

1 Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia.

Background: EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND) is a randomized, multicenter, double-blinded, placebo-controlled phase 3 trial to test the hypothesis of extending the thrombolysis time window to 9 h from stroke onset and in wake-up stroke (WUS) patients.

Objective: To formulate the detailed statistical analysis plan for the EXTEND trial prior to database lock. This statistical analysis plan is based on the published and registered EXTEND trial protocol and is developed by the blinded steering committee and management team. Read More

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http://dx.doi.org/10.1177/1747493018816101DOI Listing
December 2018
2 Reads

How do neurologists diagnose transient ischemic attack: A systematic review.

Int J Stroke 2018 Dec 3:1747493018816430. Epub 2018 Dec 3.

1 Department of Medicine, Division of Neurology, The Ottawa Hospital, Ottawa, Canada.

Background: Identifying and treating patients with transient ischemic attack is an effective means of preventing stroke. However, making this diagnosis can be challenging, and over a third of patients referred to stroke prevention clinic are ultimately found to have alternate diagnoses.

Aims: We performed a systematic review to determine how neurologists diagnose transient ischemic attack. Read More

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December 2018
9 Reads

Metabolic syndrome identifies normal weight insulin-resistant stroke patients at risk for recurrent vascular disease.

Int J Stroke 2018 Dec 3:1747493018816425. Epub 2018 Dec 3.

2 Yale School of Medicine, New Haven, CT, USA.

Background: The obesity paradox refers to the finding in observational studies that patients with obesity have a better prognosis after stroke than normal weight patients.

Aim: To test the hypothesis that there might be important heterogeneity within the obese stroke population, such that those with metabolic syndrome would be at higher risk for stroke or myocardial infarction and all-cause mortality compared to patients without metabolic syndrome.

Methods: The Insulin Resistance Intervention after Stroke trial enrolled non-diabetic patients with a recent ischemic stroke or transient ischemic attack and insulin resistance. Read More

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http://dx.doi.org/10.1177/1747493018816425DOI Listing
December 2018
10 Reads

The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies.

Int J Stroke 2018 Nov 29:1747493018816503. Epub 2018 Nov 29.

1 Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Background: Amplifying endogenous neuroprotective mechanisms is a promising avenue for stroke therapy. One target is mammalian target of rapamycin (mTOR), a serine/threonine kinase regulating cell proliferation, cell survival, protein synthesis, and autophagy. Animal studies investigating the effect of rapamycin on mTOR inhibition following cerebral ischemia have shown conflicting results. Read More

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http://dx.doi.org/10.1177/1747493018816503DOI Listing
November 2018
8 Reads

Statins as secondary preventives in patients with intracerebral hemorrhage.

Int J Stroke 2018 Nov 28:1747493018816476. Epub 2018 Nov 28.

3 Faculty of Medicine and Health, University Health Care Research Center, Örebro University, Örebro, Sweden.

Background: Statins are important components of secondary stroke prevention, but there is a concern they may increase the risk of intracerebral hemorrhage. Although this risk may have been overestimated, there is still an open question whether statin therapy should be continued, or even initiated, in patients who have had a recent intracerebral hemorrhage.

Aim: Our aim was to investigate the risk of statin use after an intracerebral hemorrhage with respect to recurrent intracerebral hemorrhage, stroke in general, and death. Read More

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November 2018
4 Reads

Low flow in the left atrial appendage assessed by transesophageal echocardiography is associated with increased stroke severity-Results of a single-center cross-sectional study.

Int J Stroke 2018 Nov 27:1747493018816511. Epub 2018 Nov 27.

1 Clinic for Neurology, University Medical Center Göttingen, Germany.

Background: About 25% of strokes are thought to be cryptogenic. There is growing evidence that most of these cryptogenic strokes are thromboembolic and caused by an undetected atrial fibrillation. Measured slow flow in the left atrial appendage has been proposed to be an indicator for the thromboembolic risk since it is possibly associated with undetected atrial fibrillation. Read More

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November 2018
11 Reads

Letter to the Editor for the article "Flat-head positioning increases cerebral blood flow in anterior circulation acute ischemic stroke: A cluster randomized phase IIb trial".

Int J Stroke 2018 Nov 27:1747493018816461. Epub 2018 Nov 27.

1 Second Department of Neurology, "Attikon" Hospital, School of Medicine, National & Kapodistrian University of Athens, Athens, Greece.

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http://dx.doi.org/10.1177/1747493018816461DOI Listing
November 2018
5 Reads

Baseline characteristics of the 1149 patients recruited into the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) randomized controlled trial.

Int J Stroke 2018 Nov 26:1747493018816451. Epub 2018 Nov 26.

1 Stroke, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.

Background: High blood pressure is common in acute stroke and associated with a worse functional outcome. Glyceryl trinitrate, a nitric oxide donor, lowers blood pressure in acute stroke and may improve outcome.

Aims: Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) tested the feasibility of performing a UK multicenter ambulance-based stroke trial, and the safety and efficacy of glyceryl trinitrate when administered by paramedics before hospital admission. Read More

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http://dx.doi.org/10.1177/1747493018816451DOI Listing
November 2018
11 Reads

Phone-based intervention for blood pressure control among Ghanaian stroke survivors: A pilot randomized controlled trial.

Int J Stroke 2018 Nov 22:1747493018816423. Epub 2018 Nov 22.

3 Neurology Unit, Medical University of South Carolina, Charleston, SC, USA.

Background: The potential of mobile-health (mHealth) technology for the management of hypertension among stroke survivors in Africa remains unexplored. We assessed whether an mHealth technology-enabled, nurse-guided intervention initiated among stroke patients within one month of symptom onset is effective in improving their blood pressure (BP) control.

Methods: A two-arm pilot cluster randomized controlled trial involving 60 stroke survivors, ≥18 years, with BP ≥140/90 mmHg at screening/enrollment visit at a medical center in Ghana. Read More

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http://dx.doi.org/10.1177/1747493018816423DOI Listing
November 2018
13 Reads

Statistical analysis plan for pooled individual patient data from two landmark randomized trials (INTERACT2 and ATACH-II) of intensive blood pressure lowering treatment in acute intracerebral hemorrhage.

Int J Stroke 2018 Nov 12:1747493018813695. Epub 2018 Nov 12.

3 Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.

Background: There is persistent uncertainty over the benefits of early intensive systolic blood pressure lowering in acute intracerebral hemorrhage. In particular, over the timing, target, and intensity of systolic blood pressure control for optimum balance of potential benefits (i.e. Read More

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November 2018
9 Reads

Stroke survivor follow-up in a national registry: Lessons learnt from respondents who completed telephone interviews.

Int J Stroke 2018 Oct 26:1747493018806190. Epub 2018 Oct 26.

1 Stroke Division, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, VIC, Australia.

The Australian Stroke Clinical Registry (AuSCR) collects patient-reported outcomes at 90-180 days post-stroke. During telephone interviews, stroke survivors or their carers/family members often explain why they did not respond to a previously mailed survey. This feedback is useful to explore respondents' experiences of the follow-up process. Read More

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October 2018
10 Reads

Systematic evaluation of stroke thrombectomy in clinical practice: The German Stroke Registry Endovascular Treatment.

Int J Stroke 2018 Oct 22:1747493018806199. Epub 2018 Oct 22.

1 Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Endovascular treatment has become standard of care for the treatment of acute ischemic stroke with large vessel occlusion. However, patients treated in clinical practice differ from the selected populations randomized in clinical trials.

Aims: The German Stroke Registry Endovascular Treatment (GSR-ET) aims at a systematic evaluation of outcome, safety, and process parameters of endovascular stroke treatment in standard of care in Germany. Read More

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http://dx.doi.org/10.1177/1747493018806199DOI Listing
October 2018
6 Reads
3.833 Impact Factor

Weekend hospital discharge is associated with suboptimal care and outcomes: An observational Australian Stroke Clinical Registry study.

Int J Stroke 2018 Oct 22:1747493018806165. Epub 2018 Oct 22.

1 Stroke and Ageing Research, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia.

Background: The quality of stroke care may diminish on weekends.

Aims: We aimed to compare the quality of care and outcomes for patients with stroke/transient ischemic attack discharged on weekdays compared with those discharged on weekends.

Methods: Data from the Australian Stroke Clinical Registry from January 2010 to December 2015 ( n = 45 hospitals) were analyzed. Read More

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October 2018
7 Reads

Frequency of post-stroke pneumonia: Systematic review and meta-analysis of observational studies.

Int J Stroke 2018 Oct 22:1747493018806196. Epub 2018 Oct 22.

2 Mental Health Program, The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia.

Background: Post-stroke pneumonia and other infectious complications are serious conditions whose frequency varies widely across studies.

Aims: We conducted a systematic review to estimate the frequency of post-stroke pneumonia and other types of major infection.

Summary Of Review: MEDLINE, EMBASE, CINAHL, and PsycINFO databases were searched for prospective studies with consecutive recruitment of stroke patients. Read More

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http://dx.doi.org/10.1177/1747493018806196DOI Listing
October 2018
27 Reads

WSO 2018 index.

Authors:

Int J Stroke 2018 Oct;13(2_suppl):245-260

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http://dx.doi.org/10.1177/1747493018789544DOI Listing
October 2018

The role of nighttime heart rate variability to detect white matter hyperintensities of presumed vascular origin in community-dwelling older adults.

Int J Stroke 2018 Dec 18;13(9):NP22-NP23. Epub 2018 Oct 18.

3 Department of Cardiology, Luis Vernaza Hospital, Guayaquil, Ecuador.

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http://dx.doi.org/10.1177/1747493018806172DOI Listing
December 2018
4 Reads

Implementing the Proclamation of Stroke and Potentially Preventable Dementias.

Int J Stroke 2018 Oct;13(8):780-786

6 Department of Neurology, Heidelberg University, Heidelberg, Germany We are pleased to submit our commentary Implementing the Proclamation of Stroke and Potentially Treatable Preventable Dementias. As this has multidisciplinary implications for the World Stroke Organization, World Heart Federation, World Hypertension League and European Society of Hypertension, we are proposing publication in both International Journal of Stroke (World Stroke Organization) and Journal of Clinical Hypertension. Drs. Weber and Donnan are aware of this manuscript and have agreed to simultaneous publication.

Brain health plays a central role in wellbeing and in the management of chronic diseases. Stroke and dementia pose the two greatest threats to brain health, but recent developments suggest the possibility that preventing stroke may also prevent some dementias: 1. A large population study showed a 32% decrease in the incidence of stroke and a concomitant 7% reduction in the incidence of dementia; 2. Read More

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October 2018
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World Stroke Day - a day of global action.

Authors:
Peter Sandercock

Int J Stroke 2018 Oct;13(8):779

Centre for Clinical Brain Sciences, University of Edinburgh, Chancellors Building, 49 Little France Drive, Edinburgh EH16 4SB, UK.

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October 2018

Systematic review of organizational models for intra-arterial treatment of acute ischemic stroke.

Int J Stroke 2018 Oct 10:1747493018806157. Epub 2018 Oct 10.

3 Department of Neurology, University Hospital Bern and University of Bern, Bern, Switzerland.

Background Intra-arterial treatment of acute ischemic stroke requires changes to acute stroke services since most hospitals do not have on-site intra-arterial treatment facilities. Aim To identify models for delivery of intra-arterial treatment and to compare process performance and clinical and radiological outcomes of the different models. Methods We systematically searched the literature and contacted experts in the field. Read More

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October 2018
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A core outcome set for aphasia treatment research: The ROMA consensus statement.

Int J Stroke 2018 Oct 10:1747493018806200. Epub 2018 Oct 10.

21 School of Education, Communication and Language Sciences, Newcastle University, Newcastle Upon Tyne, UK.

Background A core outcome set (COS; an agreed, minimum set of outcomes) was needed to address the heterogeneous measurement of outcomes in aphasia treatment research and to facilitate the production of transparent, meaningful, and efficient outcome data. Objective The Research Outcome Measurement in Aphasia (ROMA) consensus statement provides evidence-based recommendations for the measurement of outcomes for adults with post-stroke aphasia within phases I-IV aphasia treatment studies. Methods This statement was informed by a four-year program of research, which comprised investigation of stakeholder-important outcomes using consensus processes, a scoping review of aphasia outcome measurement instruments, and an international consensus meeting. Read More

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October 2018
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Glial fibrillary acidic protein for the early diagnosis of intracerebral hemorrhage: Systematic review and meta-analysis of diagnostic test accuracy.

Int J Stroke 2018 Oct 10:1747493018806167. Epub 2018 Oct 10.

1 Melbourne Brain Centre at The Royal Melbourne Hospital, University of Melbourne, Australia.

Background and aims Glial fibrillary acidic protein (GFAP) has shown promise in several studies for its ability to diagnose intracerebral hemorrhage (ICH). We evaluated the diagnostic accuracy of blood GFAP level to differentiate (ICH) from acute ischemic stroke (AIS) and stroke mimics, both overall, and in the first three hours after symptom onset. Methods We searched multiple databases, without language restriction, from inception until December 2017. Read More

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October 2018
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Evaluation of a score for the prehospital distinction between cerebrovascular disease and stroke mimic patients.

Int J Stroke 2018 Oct 10:1747493018806194. Epub 2018 Oct 10.

1 Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background Patients with a sudden onset of focal neurological deficits consistent with stroke, who turn out to have alternative conditions, have been labeled stroke mimics. Aims We assessed a recently validated telemedicine-based stroke mimic score (TeleStroke mimic score; TM-score) and individual patient characteristics with regard to its discriminative value between cerebrovascular disease and stroke mimic patients in the in-person, pre-hospital setting. Methods We evaluated patients cared for in a mobile stroke unit in Berlin, Germany. Read More

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October 2018

Statistical analysis plan for evaluating different intensities of blood pressure control in the ENhanced Control of Hypertension And Thrombolysis strokE stuDy.

Int J Stroke 2018 Oct 9:1747493018806170. Epub 2018 Oct 9.

8 Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

Background: The ENhanced Control of Hypertension And Thrombolysis strokE study (ENCHANTED) trial was initiated as a 2 × 2 partial-factorial active-comparison, prospective, randomized, open, blinded endpoint clinical trial to evaluate in thrombolysis-eligible acute ischemic stroke (AIS) patients whether: (1) Arm A - low-dose (0.6 mg/kg body weight) intravenous (iv) alteplase has noninferior efficacy and lower risk of symptomatic intracerebral hemorrhage (sICH) compared with standard-dose (0.9 mg/kg body weight) iv alteplase; and (2) Arm B - early intensive blood pressure (BP) lowering (systolic target 130-140 mmHg) has superior efficacy and lower risk of ICH compared with guideline-recommended BP control (systolic target <180 mmHg). Read More

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October 2018
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High five-year mortality rates of ischemic stroke subtypes: A prospective cohort study in Brazil.

Int J Stroke 2018 Oct 9:1747493018806197. Epub 2018 Oct 9.

6 Neurology Department, Paraná Federal University, Curitiba, Brazil.

Background: Studies regarding long-term outcomes of ischemic stroke subtypes are scarce in low- and middle-income countries. We aimed to measure the five-year prognosis of ischemic stroke subtypes in Joinville, Brazil.

Methods: All first-ever ischemic strokes that occurred in Joinville in 2010 were followed-up for five years. Read More

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October 2018
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Detecting lenticulostriate artery lesions in patients with acute ischemic stroke using high-resolution MRA at 7 T.

Int J Stroke 2018 Oct 9:1747493018806163. Epub 2018 Oct 9.

1 Department of Neurology and Gerontology Iwate Medical University, Japan.

Background Recent advances in high-resolution (HR) magnetic resonance angiography (MRA) using ultrahigh-field systems enable direct visualization of the lenticulostriate arteries (LSAs), which had been hardly achieved by conventional MRA. Hence, by using HR-MRA at 7 T, we attempted to assess occlusive changes in the LSAs in patients with LSA territorial infarcts. Methods We prospectively examined 34 consecutive patients with acute ischemic stroke in the LSA territory using a 7 T scanner. Read More

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October 2018
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Disconnectomics: Stroke-related disconnection and dysfunction in distributed brain networks.

Int J Stroke 2019 Jan 5;14(1):6-8. Epub 2018 Oct 5.

2 The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.

Modern clinical neuroscience was built on observations of how localized damage caused specific functional, cognitive and behavioral deficits. Stroke neurology was a cornerstone of understanding this functional specialization in the brain. But most lesion-symptom mapping provides little prognostic value above clinical observations. Read More

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January 2019
10 Reads