2,015 results match your criteria International Journal of Stroke [Journal]


Front index.

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Int J Stroke 2018 Dec;13(3_suppl):2-9

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http://dx.doi.org/10.1177/1747493018801108aDOI Listing
December 2018

Intracranial arterial wall imaging: Techniques, clinical applicability, and future perspectives.

Int J Stroke 2019 Apr 13:1747493019840942. Epub 2019 Apr 13.

4 Department of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, the Netherlands.

Purpose: To review the current state of the art and future development of intracranial vessel wall imaging.

Methods: Recent literature review and expert opinion about intracranial arterial wall imaging.

Results: Intracranial large artery diseases represent an important cause of stroke and vascular cognitive impairment worldwide. Read More

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http://dx.doi.org/10.1177/1747493019840942DOI Listing
April 2019
1 Read

Left ventricular wall motion abnormality is associated with cryptogenic stroke.

Int J Stroke 2019 Apr 13:1747493019834181. Epub 2019 Apr 13.

6 Department of Neurology, Korea University College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.

Background: Left ventricular wall motion abnormality (LVWMA) unrelated to known cardiac risk factors is an uncertain risk for stroke.

Aims: We evaluated whether LVWMA was associated with cryptogenic stroke.

Methods: This retrospective, observational study included 4316 acute ischemic stroke patients, and the association between cryptogenic stroke and LVWMA was examined in comparison with other stroke subtypes. Read More

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http://dx.doi.org/10.1177/1747493019834181DOI Listing
April 2019
1 Read

Improving life after stroke needs global efforts to implement evidence-based physical activity pathways.

Int J Stroke 2019 Apr 11:1747493019840930. Epub 2019 Apr 11.

13 Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

There is an urgent need to improve life after stroke across the world-especially in low-income countries-through methods that are effective, equitable and sustainable. This paper highlights physical activity (PA) as a prime candidate for implementation. PA reduces modifiable risk factors for first and recurrent stroke and improves function and activity during rehabilitation and following discharge. Read More

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http://dx.doi.org/10.1177/1747493019840930DOI Listing
April 2019
1 Read

Evaluation of the Swedish National Stroke Campaign: A population-based time-series study.

Int J Stroke 2019 Apr 10:1747493019840939. Epub 2019 Apr 10.

1 Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

Background: Time delay from stroke onset to hospital arrival is an important obstacle to recanalization therapy. To increase knowledge about stroke symptoms and potentially reduce delayed hospital arrival, a 27-month national public information campaign was conducted in Sweden.

Aim: To assess the effects of a national stroke campaign in Sweden. Read More

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http://dx.doi.org/10.1177/1747493019840939DOI Listing

Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous thrombolysis in England and Wales: Comparison with the Sentinel Stroke National Audit Programme registry.

Int J Stroke 2019 Apr 8:1747493019841246. Epub 2019 Apr 8.

6 The George Institute for Global Health, Faculty of Medicine, University of New South Wales, NSW, Australia.

Background: Randomized controlled trials provide high-level evidence, but the necessity to include selected patients may limit the generalisability of their results.

Methods: Comparisons were made of baseline and outcome data between patients with acute ischemic stroke (AIS) recruited into the alteplase-dose arm of the international, multi-center, Enhanced Control of Hypertension and Thrombolysis Stroke study (ENCHANTED) in the United Kingdom (UK), and alteplase-treated AIS patients registered in the UK Sentinel Stroke National Audit Programme (SSNAP) registry, over the study period June 2012 to October 2015.

Results: There were 770 AIS patients (41. Read More

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http://dx.doi.org/10.1177/1747493019841246DOI Listing

Impact of previous stroke on outcome after thrombectomy in patients with large vessel occlusion.

Int J Stroke 2019 Apr 4:1747493019841244. Epub 2019 Apr 4.

6 Rambam Medical Center, Haifa, Israel.

Background: Many patients with large vessel occlusion (LVO) who are otherwise candidates for endovascular treatment (EVT) have had previous strokes. We aimed to examine the effect of previous stroke on outcome after EVT.

Methods: Consecutive patients with LVO were prospectively entered into a National Acute Stroke registry of patients undergoing EVT. Read More

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http://dx.doi.org/10.1177/1747493019841244DOI Listing
April 2019
1 Read

Extending the time window for intravenous thrombolysis in acute ischemic stroke using magnetic resonance imaging-based patient selection.

Int J Stroke 2019 Apr 4:1747493019840938. Epub 2019 Apr 4.

16 Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.

Background: Intravenous thrombolysis with alteplase within a time window up to 4.5 h is the only approved pharmacological treatment for acute ischemic stroke. We studied whether acute ischemic stroke patients with penumbral tissue identified on magnetic resonance imaging 4. Read More

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http://dx.doi.org/10.1177/1747493019840938DOI Listing
April 2019
3 Reads

A randomized 500-subject open-label phase 3 clinical trial of minimally invasive surgery plus alteplase in intracerebral hemorrhage evacuation (MISTIE III).

Int J Stroke 2019 Apr 3:1747493019839280. Epub 2019 Apr 3.

2 Division of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.

Rationale And Hypothesis: Surgical removal of spontaneous intracerebral hemorrhage may reduce secondary destruction of brain tissue. However, large surgical trials of craniotomy have not demonstrated definitive improvement in clinical outcomes. Minimally invasive surgery may limit surgical tissue injury, and recent evidence supports testing these approaches in large clinical trials. Read More

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http://dx.doi.org/10.1177/1747493019839280DOI Listing
April 2019
3 Reads

Is breathing our polluted air a risk factor for stroke?

Authors:
Conrado J Estol

Int J Stroke 2019 Apr 3:1747493019832999. Epub 2019 Apr 3.

Stroke Unit, Sanatorio Guemes, Francisco Acuña de Figueroa 1240, C1180, CABA, Argentina.

The conference "Climate change, air pollution and health" was held at the Pontifical Academy of Sciences. The data presented highlighted that air pollution is a major, under-recognized and modifiable risk factor for stroke and heart disease. Air pollution causes 7. Read More

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http://dx.doi.org/10.1177/1747493019832999DOI Listing
April 2019
1 Read

Measuring the effects of listening for leisure on outcome after stroke (MELLO): A pilot randomized controlled trial of mindful music listening.

Int J Stroke 2019 Apr 2:1747493019841250. Epub 2019 Apr 2.

1 Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.

Background: Cognitive deficits and low mood are common post-stroke. Music listening is suggested to have beneficial effects on cognition, while mindfulness may improve mood. Combining these approaches may enhance cognitive recovery and improve mood early post-stroke. Read More

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http://dx.doi.org/10.1177/1747493019841250DOI Listing
April 2019
4 Reads

Long-term stroke incidence in proximal thoracic aorta aneurysm survivors.

Int J Stroke 2019 Apr 2:1747493019840944. Epub 2019 Apr 2.

1 Department of Neurology, Buddhist Tzu Chi General Hospital, Hualien.

Background: Aneurysm of proximal thoracic aorta (pTAA) is an often indolent, yet fatal disease. Although advancements in aneurysmal repair techniques have increased long-term survival rates, studies have proven that there are increases in perioperative risk for stroke incidence after pTAA surgery. Conversely, there is little evidence regarding the long-term stroke incidence in pTAA individuals, which strongly influences the morbidity, mortality, and usage of antithrombotic agents. Read More

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http://dx.doi.org/10.1177/1747493019840944DOI Listing
April 2019
3 Reads

NLRP3 inflammasome in ischemic stroke: As possible therapeutic target.

Int J Stroke 2019 Apr 2:1747493019841242. Epub 2019 Apr 2.

5 Department of Physiology, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Inflammation is a devastating pathophysiological process during stroke, a devastating disease that is the second most common cause of death worldwide. Activation of the NOD-like receptor protein (NLRP3)-infammasome has been proposed to mediate inflammatory responses during ischemic stroke. Briefly, NLRP3 inflammasome activates caspase-1, which cleaves both pro-IL-1 and pro-IL-18 into their active pro-inflammatory cytokines that are released into the extracellular environment. Read More

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http://dx.doi.org/10.1177/1747493019841242DOI Listing
April 2019
7 Reads
3.833 Impact Factor

Extension of therapeutic window in ischemic stroke by selective mismatch imaging.

Int J Stroke 2019 Apr 1:1747493019840936. Epub 2019 Apr 1.

1 Max Planck Institute for Metabolism Research, Cologne, Germany.

The concept of the ischemic penumbra was formulated on the basis of animal experiments showing functional impairment and electrophysiologic disturbances with decreasing flow to the brain below defined values (the threshold for function) and irreversible tissue damage with blood supply further decreased (the threshold for infarction). The perfusion range between these thresholds was termed the "penumbra," and restitution of flow above the functional threshold was able to reverse the deficits without permanent damage. In further experiments, the dependency of the development of irreversible lesions on the interaction of the severity and the duration of critically reduced blood flow was established, proving that the lower the flow, the shorter the time for efficient reperfusion. Read More

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http://dx.doi.org/10.1177/1747493019840936DOI Listing

Outcome after intravenous thrombolysis in patients with acute lacunar stroke: An observational study based on SITS international registry and a meta-analysis.

Int J Stroke 2019 Apr 1:1747493019840947. Epub 2019 Apr 1.

1 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Background: Intravenous thrombolysis (IVT) for lacunar stroke (LS) is debated, as the underlying pathophysiological mechanism may not be thrombogenic.

Aims: To investigate outcomes after IVT in LS in the SITS International Stroke Thrombolysis Register and perform a meta-analysis.

Methods: LS was identified by both baseline NIHSS-subscores and discharge ICD-10 codes, and contrasted by IVT to non-IVT treated. Read More

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http://journals.sagepub.com/doi/10.1177/1747493019840947
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http://dx.doi.org/10.1177/1747493019840947DOI Listing
April 2019
2 Reads

Response to letter by Samuels et al.

Int J Stroke 2019 Apr 1:1747493019840929. Epub 2019 Apr 1.

4 Department of Neurology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1177/1747493019840929DOI Listing
April 2019
2 Reads

The randomized study of endovascular therapy with versus without intravenous tissue plasminogen activator in acute stroke with ICA and M1 occlusion (SKIP study).

Int J Stroke 2019 Mar 29:1747493019840932. Epub 2019 Mar 29.

11 Division of Stroke Prevention and Treatment, Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Rationale: Bridging therapy with endovascular therapy (EVT) and intravenous thrombolysis (IVT) has been reported to improve outcomes for acute stroke patients with large-vessel occlusion in the anterior circulation. While the IVT may increase the reperfusion rate, the risk of hemorrhagic complications increases. Whether EVT without IVT (direct EVT) is equally effective as bridging therapy in acute stroke remains unclear. Read More

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http://dx.doi.org/10.1177/1747493019840932DOI Listing
March 2019
1 Read

14th International Symposium on Thrombolysis, Thrombectomy and Acute Stroke Therapy: Proceedings and summary of discussions.

Int J Stroke 2019 Mar 28:1747493019838760. Epub 2019 Mar 28.

3 Clinical Innovation and Research Institute Memorial Hermann Hospital, Texas Medical Center, Houston, TX, USA.

The 14th International Symposium on Thrombolysis, Thrombectomy and Acute Stroke Therapy (TTST) took place in Houston, Texas on 21-22 October 2018. Attended by 150+ invited global experts, the objectives of TTST 2018 were to explore the changing landscape of acute ischemic stroke therapy and to address current controversies in thrombolysis and thrombectomy, including expanding access and systems of care with global relevance. This article summarizes the proceedings of TTST 2018. Read More

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http://dx.doi.org/10.1177/1747493019838760DOI Listing
March 2019
1 Read

Small vessel occlusion is a high-risk etiology for early recurrent stroke after transient ischemic attack.

Int J Stroke 2019 Mar 27:1747493019840931. Epub 2019 Mar 27.

1 Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.

Background: Recent prospective registration studies of transient ischemic attack in Western countries demonstrated that large artery atherosclerosis is the highest risk etiology for early stroke recurrence under urgent evaluation and treatment. On the other hand, some limited transient ischemic attack studies from East Asian countries showed transient ischemic attack patients due to small vessel occlusion were at a higher early stroke risk.

Aims: We aimed to assess the risk for early stroke in small vessel occlusion-transient ischemic attack patients in a Japanese large transient ischemic attack registry. Read More

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http://dx.doi.org/10.1177/1747493019840931DOI Listing
March 2019
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Comprehensive assessment of disability post-stroke using the newly developed miFUNCTION scale.

Int J Stroke 2019 Mar 27:1747493019840933. Epub 2019 Mar 27.

7 Departments of Clinical Neurosciences, Community Health Sciences, Medicine, and Radiology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background And Purpose: The modified Rankin Scale (mRS) is the most widely used primary outcome measure in acute stroke trials. However, substantial interobserver variability impairs outcome assessment as well as reduces power of clinical trials. Guided by the International Classification of Functioning, Disability and Health, we developed a comprehensive, hierarchical assessment tool (miFUNCTION) to address the shortcomings of the modified Rankin Scale and deliver a more thorough understanding of disability following stroke. Read More

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http://dx.doi.org/10.1177/1747493019840933DOI Listing

IER-START nomogram for prediction of three-month unfavorable outcome after thrombectomy for stroke.

Int J Stroke 2019 Mar 25:1747493019837756. Epub 2019 Mar 25.

20 Sapienza University Hospital, Roma, Italy.

Background: The applicability of the current models for predicting functional outcome after thrombectomy in strokes with large vessel occlusion (LVO) is affected by a moderate predictive performance.

Aims: We aimed to develop and validate a nomogram with pre- and post-treatment factors for prediction of the probability of unfavorable outcome in patients with anterior and posterior LVO who received bridging therapy or direct thrombectomy <6 h of stroke onset.

Methods: We conducted a cohort study on patients data collected prospectively in the Italian Endovascular Registry (IER). Read More

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http://journals.sagepub.com/doi/10.1177/1747493019837756
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http://dx.doi.org/10.1177/1747493019837756DOI Listing
March 2019
4 Reads

Antiplatelet vs. R-tPA for acute mild ischemic stroke: A prospective, random, and open label multi-center study.

Int J Stroke 2019 Mar 25:1747493019832998. Epub 2019 Mar 25.

Department of Neurology, General Hospital of Northern Theater Command, Shenyang, P.R. China.

Rationale: The evidence of intravenous thrombolysis in patients with not clearly disabling minor stroke (low National Institutes of Health Stroke Scale of 0-5) is still insufficient. Recent early terminated PRISMS trial could not provide definitive conclusion, although suggesting the similar functional outcome between alteplase and aspirin groups. Recent two clinical trials provide a definitive evidence for the superiority of dual antiplatelet to mono-antiplatelet in minor stroke. Read More

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http://dx.doi.org/10.1177/1747493019832998DOI Listing
March 2019
3.833 Impact Factor

4G versus 3G-enabled telemedicine in prehospital acute stroke care.

Int J Stroke 2019 Mar 15:1747493019830303. Epub 2019 Mar 15.

1 Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Time to reperfusion treatment is closely related to outcome in ischemic stroke. Prehospital stroke work-up in CT-equipped mobile stroke units is effective in reducing time to thrombolytic treatment. Current evidence predominantly comes from mobile stroke units staffed with neurologists but telemedicine-guided management may be acceptable for providing neurological expertise in ambulances. Read More

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http://dx.doi.org/10.1177/1747493019830303DOI Listing
March 2019
3 Reads

Factors, trends, and long-term outcomes for stroke patients returning to work: The South London Stroke Register.

Int J Stroke 2019 Mar 15:1747493019832997. Epub 2019 Mar 15.

1 Guy's and St Thomas' NHS Foundation Trust, London, UK.

Background And Purpose: There is limited information on factors, trends, and outcomes in return to work at different time-points post-stroke; this study aims to identify these in a multi-ethnic urban population.

Methods: Patterns of return to work were identified in individuals in paid work prior to first-ever stroke in the population-based South London Stroke Register (SLSR) between 1995 and 2014. Multivariable logistic regression examined associations between patient characteristics and return to work at 1 year (1 y), 5 years (5 y) and 10 years (10 y) post-stroke. Read More

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http://dx.doi.org/10.1177/1747493019832997DOI Listing
March 2019
3 Reads

Angioplasty in asymptomatic carotid artery stenosis vs. endarterectomy compared to best medical treatment: One-year interim results of SPACE-2.

Int J Stroke 2019 Mar 15:1747493019833017. Epub 2019 Mar 15.

1 Department of Neurology, University Hospital of Heidelberg, Heidelberg, Germany.

Background: Treatment of individuals with asymptomatic carotid artery stenosis is still handled controversially. Recommendations for treatment of asymptomatic carotid stenosis with carotid endarterectomy (CEA) are based on trials having recruited patients more than 15 years ago. Registry data indicate that advances in best medical treatment (BMT) may lead to a markedly decreasing risk of stroke in asymptomatic carotid stenosis. Read More

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http://dx.doi.org/10.1177/1747493019833017DOI Listing
March 2019
2 Reads

Racial/ethnic disparities in hospital utilization in intracerebral hemorrhage.

Int J Stroke 2019 Mar 14:1747493019835335. Epub 2019 Mar 14.

Department of Neurology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.

Background And Purpose: There is evidence that racial and ethnic differences among intracerebral hemorrhage (ICH) patients exist. We sought to establish the occurrence of disparities in hospital utilization in the United States.

Methods: We identified ICH patients from United States Nationwide Inpatient Sample database for years 2006-2014 using codes (DX1 = 431, 432. Read More

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http://dx.doi.org/10.1177/1747493019835335DOI Listing
March 2019
3 Reads

Comparison of acute ischemic stroke evaluation and the etiologic subtypes between university and nonuniversity hospitals in Isfahan, Iran.

Int J Stroke 2019 Mar 12:1747493019828648. Epub 2019 Mar 12.

1 Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Background And Purpose: Performing a proper causative workup for ischemic stroke patients is essential as it guides the direction of primary and secondary preventions. We aim to investigate the etiological evaluation of these patients in university and nonuniversity hospitals.

Method: We enrolled subjects from the Persian Registry of Cardiovascular Disease-stroke. Read More

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http://dx.doi.org/10.1177/1747493019828648DOI Listing
March 2019
1 Read
3.833 Impact Factor

Stroke in the Middle-East and North Africa: A 2-year prospective observational study of stroke characteristics in the region-Results from the Safe Implementation of Treatments in Stroke (SITS)-Middle-East and North African (MENA).

Int J Stroke 2019 Mar 12:1747493019830331. Epub 2019 Mar 12.

2 Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.

Background And Methods: Stroke incidence and mortality are reported to have increased in the Middle-East and North African (MENA) countries during the last decade. This was a prospective observational study to examine the baseline characteristics of stroke patients in the MENA region and to compare the MENA vs. the non-MENA stroke cohort in the Safe Implementation of Treatments in Stroke (SITS) International Registry. Read More

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http://dx.doi.org/10.1177/1747493019830331DOI Listing
March 2019
4 Reads
3.833 Impact Factor

Sex differences in stroke metrics among Southeast Asian countries: Results from the Global Burden of Disease Study 2015.

Int J Stroke 2019 Mar 6:1747493019832995. Epub 2019 Mar 6.

2 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.

Background: Sex differences in cardiovascular diseases generally disadvantage women, particularly within developing regions.

Aims: This study aims to examine sex-related differences in stroke metrics across Southeast Asia in 2015. Furthermore, relative changes between sexes are compared from 1990 to 2015. Read More

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http://dx.doi.org/10.1177/1747493019832995DOI Listing
March 2019
7 Reads

RE: Clinical stroke research in resource limited settings: Tips and hints.

Int J Stroke 2019 Apr 28;14(3):NP11-NP12. Epub 2019 Feb 28.

2 Kilimanjaro Christian Medical Centre Moshi, United Republic of Tanzania.

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http://dx.doi.org/10.1177/1747493019833011DOI Listing
April 2019
1 Read
3.833 Impact Factor

Bringing stroke clinical guidelines to life.

Int J Stroke 2019 Feb 26:1747493019833015. Epub 2019 Feb 26.

13 Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Australia.

Clinical practice guidelines are essential for driving evidence-based clinical care to patients. In an era of ever-increasing research evidence, keeping guidelines up to date is a challenging and resource-intensive process. Advances in technological platforms provide opportunities to develop new models of guideline development that will allow for continuous, rapid updates to recommendations as new evidence emerges. Read More

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http://dx.doi.org/10.1177/1747493019833015DOI Listing
February 2019
5 Reads

Education in stroke.

Authors:
Geoffrey Donnan

Int J Stroke 2019 Feb;14(2):111

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http://dx.doi.org/10.1177/1747493018823654DOI Listing
February 2019
2 Reads

Editorial.

Authors:
Geoffrey Donnan

Int J Stroke 2019 Jan;14(1)

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http://dx.doi.org/10.1177/1747493018816530DOI Listing
January 2019
2 Reads

Validation and iteration of CT perfusion defined malignant profile thresholds for acute ischemic stroke.

Int J Stroke 2019 Feb 22:1747493019832987. Epub 2019 Feb 22.

1 Department of Neurology, University of California, San Francisco, CA, USA.

Background: Malignant profile computed tomography perfusion (CTP) lesions are associated with poor outcomes after administration of intravenous tissue-plasminogen activator (IV-tPA) for ischemic stroke.

Aims: To determine whether published CTP-based lesion thresholds predictive of poor outcomes in a predominantly 8 cm of CTP anatomic coverage cohort would predict poor outcomes in an independent 4 cm of CTP anatomic coverage cohort and to generate optimized 4 cm CTP thresholds.

Methods: Ischemic stroke patients with baseline CTP imaging with 4 cm of anatomic coverage before receiving IV-tPA at a single institution were retrospectively studied. Read More

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http://dx.doi.org/10.1177/1747493019832987DOI Listing
February 2019
1 Read

Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice.

Int J Stroke 2019 Feb 22:1747493019834191. Epub 2019 Feb 22.

1 Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

Background: Stroke is a major cause of disability and mortality. Poorer outcome after stroke is associated with concomitant inflammatory and infectious disease. Periodontitis is a chronic inflammatory disease of the dental supporting structures and is a prominent risk factor for many systemic disorders, including cardiovascular disease and stroke. Read More

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http://dx.doi.org/10.1177/1747493019834191DOI Listing
February 2019
6 Reads

Anthology of stroke epidemiology in the 20th and 21st centuries: Assessing the past, the present, and envisioning the future.

Authors:
Valery L Feigin

Int J Stroke 2019 Apr 22;14(3):223-237. Epub 2019 Feb 22.

National Institute for Stroke and Applied Neurosciences, School of Public Health and Psychosocial Studies, Faculty of Health and Environmental Sciences, AUT University, Auckland, New Zealand.

This narrative overview of stroke epidemiology shows dramatic changes in stroke incidence, prevalence, mortality, disability, and the understanding of risk factors and primary stroke prevention strategies over the last few decades. Likely future directions of stroke epidemiology and prevention are outlined. Read More

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http://dx.doi.org/10.1177/1747493019832996DOI Listing

Incidence, clinical features and outcomes of atrial fibrillation and stroke in Qatar.

Int J Stroke 2019 Feb 21:1747493019830577. Epub 2019 Feb 21.

1 Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.

Background: Atrial fibrillation is an important risk factor for stroke but there are limited data on atrial fibrillation-related stroke from the Middle East.

Methods: We interrogated the Qatar Stroke Database to establish the occurrence, clinical features, and outcomes of atrial fibrillation-related stroke at Hamad General Hospital, the sole provider of acute stroke care in Qatar.

Results: A total of 4079 patients (81. Read More

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http://dx.doi.org/10.1177/1747493019830577DOI Listing
February 2019

English et al. Frequent, short bouts of light-intensity exercises while standing decreases systolic blood pressure: Breaking Up Sitting Time after Stroke (BUST-Stroke).

Int J Stroke 2019 Feb 21:1747493019833020. Epub 2019 Feb 21.

3 Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1177/1747493019833020DOI Listing
February 2019

Chest infection within 30 days of acute stroke, associated factors, survival and the benefits of stroke unit care: Analysis using linked data from the Australian Stroke Clinical Registry.

Int J Stroke 2019 Feb 21:1747493019833008. Epub 2019 Feb 21.

2 Stroke and Ageing Research, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria Australia.

Introduction: Chest infections following acute stroke contribute to increased morbidity and mortality. We aimed to investigate factors associated with chest infections that occur within 30 days of stroke, the impact on 90-day survival, and the role of stroke unit care.

Methods: Patient-level data from the Australian Stroke Clinical Registry (2010-13; 23 Queensland hospitals), were linked with Queensland hospital admission, emergency department (ED), and national death registry data. Read More

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http://dx.doi.org/10.1177/1747493019833008DOI Listing
February 2019
1 Read

First application of a Spanish version simplified modified Rankin Scale questionnaire.

Int J Stroke 2019 Feb 21:1747493019832983. Epub 2019 Feb 21.

5 School of Medicine, Universidad Espíritu Santo - Ecuador, Guayaquil, Ecuador.

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http://dx.doi.org/10.1177/1747493019832983DOI Listing
February 2019
2 Reads

ICARUSS: An effective model for risk factor management in stroke survivors.

Int J Stroke 2019 Feb 20:1747493019830582. Epub 2019 Feb 20.

5 Sir Charles Gairdner Hospital, Nedlands, Australia.

Background And Purpose: After an initial stroke, the risk of recurrent stroke is high. Models that implement best-practice recommendations for risk factor management in stroke survivors to prevent stroke recurrence remain elusive. We examined a model which focuses on vascular risk factor management to prevent stroke recurrence in survivors returning to their primary care physicians. Read More

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http://journals.sagepub.com/doi/10.1177/1747493019830582
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http://dx.doi.org/10.1177/1747493019830582DOI Listing
February 2019
9 Reads

Cortical superficial siderosis and recurrent intracerebral hemorrhage risk in cerebral amyloid angiopathy: Large prospective cohort and preliminary meta-analysis.

Int J Stroke 2019 Feb 20:1747493019830065. Epub 2019 Feb 20.

1 Department of Neurology, Hemorrhagic Stroke Research Program, JPK Stroke Research Center, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

Background: We aimed to investigate cortical superficial siderosis as an MRI predictor of lobar intracerebral hemorrhage (ICH) recurrence risk in cerebral amyloid angiopathy (CAA), in a large prospective MRI cohort and a systematic review.

Methods: We analyzed a single-center MRI prospective cohort of consecutive CAA-related ICH survivors. Using Kaplan-Meier and Cox regression analyses, we investigated cortical superficial siderosis and ICH risk, adjusting for known confounders. Read More

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http://dx.doi.org/10.1177/1747493019830065DOI Listing
February 2019
2 Reads
3.833 Impact Factor

Hypoperfusion in lenticulostriate arteries territory related to unexplained early neurological deterioration after intravenous thrombolysis.

Int J Stroke 2019 Apr 19;14(3):306-309. Epub 2019 Feb 19.

1 Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.

Background: Early neurological deterioration occurs in approximately 10% acute ischemic stroke patients after thrombolysis. Over half of the early neurological deterioration occurred without known causes and is called unexplained early neurological deterioration.

Aims: We aimed to explore the development of early neurological deterioration at 24 h after thrombolysis, and whether it could be predicted by the presence of baseline hypoperfusion in lenticulostriate arteries territory in acute ischemic stroke patients. Read More

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http://dx.doi.org/10.1177/1747493019830595DOI Listing
April 2019
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Management of oral anticoagulation after intracerebral hemorrhage.

Int J Stroke 2019 Apr 14;14(3):238-246. Epub 2019 Feb 14.

Department of Neurology, University Hospital Erlangen, Erlangen, Germany.

Background: The most recent years have significantly expanded knowledge regarding risks and benefits of resuming oral anticoagulation (OAC) after intracerebral hemorrhage (ICH). No randomized data is yet available, though several large observational studies and meta-analyses have investigated the impact of resuming OAC on thromboembolic versus hemorrhagic complications in these high-risk patients after ICH.

Aims: The present review will summarize the most important studies conducted over the last years and will focus on relevant factors help guiding on decision-making on whether to start OAC after ICH. Read More

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http://dx.doi.org/10.1177/1747493019828555DOI Listing
April 2019
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Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis.

Int J Stroke 2019 Feb 14:1747493019830321. Epub 2019 Feb 14.

1 Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.

Background: Perivascular spaces, visible on brain magnetic resonance imaging, are thought to be associated with small vessel disease, neuroinflammation, and to be important for cerebral hemodynamics and interstitial fluid drainage.

Aims: To benchmark current knowledge on perivascular spaces associations with risk factors, neurological disorders, and neuroimaging lesions, using systematic review and meta-analysis.

Summary Of Review: We searched three databases for perivascular spaces publications, calculated odds ratios with 95% confidence interval and performed meta-analyses to assess adjusted associations with perivascular spaces. Read More

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http://dx.doi.org/10.1177/1747493019830321DOI Listing
February 2019
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The effect of cerebellar transcranial direct current stimulation to improve standing balance performance early post-stroke, study protocol of a randomized controlled trial.

Int J Stroke 2019 Feb 13:1747493019830312. Epub 2019 Feb 13.

1 Department of Rehabilitation Medicine, Amsterdam Neurosciences and Amsterdam Movement Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Rationale: Restoration of adequate standing balance after stroke is of major importance for functional recovery. POstural feedback ThErapy combined with Non-invasive TranscranIAL direct current stimulation (tDCS) in patients with stroke (POTENTIAL) aims to establish if cerebellar tDCS has added value in improving standing balance performance early post-stroke.

Methods: Forty-six patients with a first-ever ischemic stroke will be enrolled in this double-blind controlled trial within five weeks post-stroke. Read More

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http://dx.doi.org/10.1177/1747493019830312DOI Listing
February 2019

Cost-utility analysis of mechanical thrombectomy between 6 and 24 hours in acute ischemic stroke.

Int J Stroke 2019 Feb 13:1747493019830587. Epub 2019 Feb 13.

2 Imaging Department, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK.

Background: Recently, two randomized controlled trials demonstrated the benefit of mechanical thrombectomy performed between 6 and 24 h in acute ischemic stroke. The current economic evidence is supporting the intervention only within 6 h, but extended thrombectomy treatment times may result in better long-term outcomes for a larger cohort of patients.

Aims: We compared the cost-utility of mechanical thrombectomy in addition to medical treatment versus medical treatment alone performed beyond 6 h from stroke onset in the UK National Health Service (NHS). Read More

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http://dx.doi.org/10.1177/1747493019830587DOI Listing
February 2019

Targets for improving dispatcher identification of acute stroke.

Int J Stroke 2019 Feb 13:1747493019830315. Epub 2019 Feb 13.

1 Neurology, Clinical Neurosciences, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Accurate identification of acute stroke by Emergency Medical Dispatchers (EMD) is essential for timely and purposeful deployment of Emergency Medical Services (EMS), and a prerequisite for operating mobile stroke units. However, precision of EMD stroke recognition is currently modest.

Aims: We sought to identify targets for improving dispatcher stroke identification. Read More

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http://dx.doi.org/10.1177/1747493019830315DOI Listing
February 2019
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