239 results match your criteria International Journal of Rheumatology [Journal]


Vertebral Fractures among Patients Referred for Bone Densitometry Screening in Dubai Primary Health Care Facilities.

Int J Rheumatol 2019 6;2019:7974534. Epub 2019 Mar 6.

Strategy & Governance Department, Dubai Health Authority, Dubai, UAE.

Vertebral fractures are one of the most common fractures associated with low bone mineral density. However two-thirds to three-fourths of patients with vertebral fractures are not clinically recognized. The objective of this study was to determine the prevalence of vertebral fractures in patients referred for bone densitometry and the most common site of fracture. Read More

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http://dx.doi.org/10.1155/2019/7974534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431384PMC
March 2019
2 Reads

Medication Adherence and Coping Strategies in Patients with Rheumatoid Arthritis: A Cross-Sectional Study.

Int J Rheumatol 2019 4;2019:4709645. Epub 2019 Mar 4.

Institute of Social Medicine, Centre for Public Health, Medical University of Vienna, Kinderspitalgasse 15/1, 1090 Vienna, Austria.

Objectives: The aim of this study was to determine if strategies for coping with illnesses, demographic factors, and clinical factors were associated with medication adherence among patients with rheumatoid arthritis (RA).

Methods: This cross-sectional study was conducted at a Viennese rheumatology outpatient clinic on RA patients. Medication adherence was assessed using the Medication Adherence Report Scale. Read More

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http://dx.doi.org/10.1155/2019/4709645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425297PMC
March 2019
2 Reads

Impact of a Student-Led Rheumatology Interest Group on Medical Student Interest in Rheumatology.

Int J Rheumatol 2019 24;2019:4892707. Epub 2019 Feb 24.

Division of Rheumatology, Ideas to Health Laboratory, The George Washington University, School of Medicine and Health Sciences, 701 Ross Hall, 2300 Eye Street, NW, Washington, DC 20037, USA.

Objectives: This observational study was designed to evaluate the impact of a student-led Rheumatology Interest Group on medical student interest in rheumatology.

Methods: The mean numbers of student-rheumatology interactions per six months were assessed for elective enrollment, abstract submissions, and manuscripts, in the pre- and postinterest group period.

Results: Enrollment in the rheumatology elective increased from 2. Read More

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http://dx.doi.org/10.1155/2019/4892707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409022PMC
February 2019

Effects of the Cathepsin K Inhibitor ONO-5334 and Concomitant Use of ONO-5334 with Methotrexate on Collagen-Induced Arthritis in Cynomolgus Monkeys.

Int J Rheumatol 2019 17;2019:5710340. Epub 2019 Feb 17.

Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.

We examined whether the cathepsin K inhibitor, ONO-5334, administered alone or in combination with methotrexate (MTX), could ameliorate joint destruction evoked by collagen-induced arthritis (CIA) in female cynomolgus monkeys. CIA was induced by immunizing with bovine type II collagen. ONO-5334 (30 mg/kg/day) was orally administered once daily and MTX (10 mg/body/day) twice weekly for 9 weeks. Read More

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http://dx.doi.org/10.1155/2019/5710340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397998PMC
February 2019
2 Reads

Febuxostat and Cardiovascular Events: A Systematic Review and Meta-Analysis.

Int J Rheumatol 2019 3;2019:1076189. Epub 2019 Feb 3.

Division of Population Health and Computational Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.

Background: Febuxostat is approved in the United States for the management of hyperuricemia in patients with gout. In November 2017 the FDA released a warning alert on a possible link between febuxostat and cardiovascular disease (CVD) reported in a single clinical trial.

Objective: To conduct a systematic review and meta-analysis and assess the risk of major adverse cardiovascular events (MACE) in patients receiving febuxostat compared to a control group. Read More

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http://dx.doi.org/10.1155/2019/1076189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378016PMC
February 2019
1 Read

Are All Oral COX-2 Selective Inhibitors the Same? A Consideration of Celecoxib, Etoricoxib, and Diclofenac.

Authors:
Chris Walker

Int J Rheumatol 2018 9;2018:1302835. Epub 2018 Dec 9.

Pfizer, Walton Oaks, UK.

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used for the treatment of arthritic conditions. Drugs in this heterogeneous class alleviate pain and inflammation by inhibiting cyclooxygenase-2 (COX-2). Cyclooxygenase-1 (COX-1) inhibition has traditionally been associated with increased gastrointestinal (GI) harm, whereas increased COX-2 selectivity has more recently become associated with greater risk of cardiovascular (CV) harm. Read More

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http://dx.doi.org/10.1155/2018/1302835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304524PMC
December 2018
2 Reads

The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis.

Int J Rheumatol 2018 21;2018:2586916. Epub 2018 Oct 21.

Barzilai Medical Center, Ashkelon, Israel.

Objectives: To assess the correlation between prednisone and methotrexate (MTX) treatment duration and dosage with the TST induration diameter of the TST reaction among rheumatoid arthritis (RA) patients.

Method: We retrospectively analyzed consecutive cases of RA patients who were TNF-i therapy candidates. TST measurements, prednisone and methotrexate dosages, and treatment durations were recorded. Read More

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http://dx.doi.org/10.1155/2018/2586916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215561PMC
October 2018
2 Reads

Population-Wide Associations between Common Viral Pathogens and Self-Reported Arthritis: NHANES 2009-2012.

Int J Rheumatol 2018 1;2018:7684942. Epub 2018 Oct 1.

Associate Professor of Medicine at the University of Minnesota, Division of Renal Diseases and Hypertension, USA.

Objective: Persistent infectious agents have been implicated in chronic and recurrent inflammation, which may trigger or worsen many types of arthritis. Our objective was to determine whether exposure to herpes simplex virus (HSV) and human papillomavirus (HPV) is associated with self-reported arthritis among US adults.

Methods: We used data from two consecutive cycles of the National Health and Nutrition Examination Survey (NHANES) from 2009 until 2012 (N of examined adults ages 20-69 = 9483). Read More

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https://www.hindawi.com/journals/ijr/2018/7684942/
Publisher Site
http://dx.doi.org/10.1155/2018/7684942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188724PMC
October 2018
15 Reads

Red Cell Distribution Width Is Positively Correlated with Atherosclerotic Cardiovascular Disease 10-Year Risk Score, Age, and CRP in Spondyloarthritis with Axial or Peripheral Disease.

Int J Rheumatol 2018 27;2018:2476239. Epub 2018 Sep 27.

Rheumatology Section, Louis Stokes Cleveland VA, Cleveland, OH, USA.

Background: Red blood cell distribution width (RDW) is a routine hematologic parameter that is a predictor of cardiovascular disease (CVD) events and is independent of combined traditional risk factor scoring systems. The RDW has also been associated with rheumatic disease activity. Whether RDW is associated with traditional CVD risk factors or Atherosclerotic Cardiovascular Disease (ASCVD) 10-year CVD risk score in patients with seronegative spondyloarthritis with axial or peripheral disease has not been previously determined. Read More

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https://www.hindawi.com/journals/ijr/2018/2476239/
Publisher Site
http://dx.doi.org/10.1155/2018/2476239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181003PMC
September 2018
14 Reads

Integration of Genome-Wide DNA Methylation and Transcription Uncovered Aberrant Methylation-Regulated Genes and Pathways in the Peripheral Blood Mononuclear Cells of Systemic Sclerosis.

Int J Rheumatol 2018 2;2018:7342472. Epub 2018 Sep 2.

Department of Rheumatology & Immunology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.

Systemic sclerosis (SSc) is a systemic connective tissue disease of unknown etiology. Aberrant gene expression and epigenetic modifications in circulating immune cells have been implicated in the pathogenesis of SSc. This study is to delineate the interaction network between gene transcription and DNA methylation in PBMC of SSc patients and to identify methylation-regulated genes which are involved in the pathogenesis of SSc. Read More

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http://dx.doi.org/10.1155/2018/7342472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139224PMC
September 2018
3 Reads

Work Ability and Employment in Rheumatoid Arthritis: A Cross-Sectional Study on the Role of Muscle Strength and Lower Extremity Function.

Int J Rheumatol 2018 1;2018:3756207. Epub 2018 Aug 1.

Department of Social and Preventive Medicine, Centre for Public Health, Medical University of Vienna, Vienna, Austria.

Objective: The aim of the present study was to assess the association between muscle strength, lower extremity function, employment status, and work ability in RA patients.

Methods: One hundred seropositive RA outpatients of working age were included in this cross-sectional study. Employment status was assessed by interview and work ability by the Work Ability Index-Single Item Scale (WAS). Read More

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http://dx.doi.org/10.1155/2018/3756207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093007PMC
August 2018
13 Reads

Wrist Arthrodesis in Rheumatoid Arthritis Using an LCP Metaphyseal Locking Plate versus an AO Wrist Fusion Plate.

Int J Rheumatol 2018 10;2018:4719634. Epub 2018 Jul 10.

Department of Rheumatology, JCHO Yugawara Hospital, 438 Miyakami, Yugawara, Ashigara-shimo, Kanagawa 259-0396, Japan.

Objectives: Although wrist arthrodesis using a plate is an established treatment with a well-documented successful union rate for severely destroyed wrists, plate-related complications are a matter of great concern.

Methods: We retrospectively compared wrist arthrodesis using an AO wrist fusion plate in nine and a locking compression plate (LCP) metaphyseal plate in seven cases of rheumatoid arthritis.

Results: The mean follow-up was 40. Read More

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http://dx.doi.org/10.1155/2018/4719634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077619PMC
July 2018
5 Reads

Gum Arabic Fibers Decreased Inflammatory Markers and Disease Severity Score among Rheumatoid Arthritis Patients, Phase II Trial.

Int J Rheumatol 2018 5;2018:4197537. Epub 2018 Jul 5.

Department of Physiology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Background: Rheumatoid arthritis (RA) is autoimmune inflammatory disease that attacks the synovium of the joints. Both TNF and interleukin-1 play crucial roles in the pathogenesis of RA. Gum Arabic (GA) is gummy exudates from tree. Read More

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http://dx.doi.org/10.1155/2018/4197537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077585PMC
July 2018
3 Reads

Possible Modulation of Vascular Function Measures in Rheumatoid Arthritis by Homocysteine.

Int J Rheumatol 2018 2;2018:8498651. Epub 2018 Jul 2.

Department of Applied Biology, Faculty of Art and Science, Jordan University of Science and Technology, Irbid, Jordan.

The effect of homocysteine on cardiovascular diseases is still equivocal, especially in rheumatoid arthritis patients. In this investigation, the association between homocysteine with blood flow and vascular resistance in rheumatoid arthritis was examined. Serum levels of homocysteine were determined in thirty-one rheumatoid arthritis patients and nineteen apparently healthy subjects using ELISA. Read More

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http://dx.doi.org/10.1155/2018/8498651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051258PMC
July 2018
3 Reads

Musculoskeletal Disorders in Patients with Diabetes Mellitus: A Cross-Sectional Study.

Int J Rheumatol 2018 19;2018:3839872. Epub 2018 Jun 19.

Rheumatology Department, Mohammed V Military Academic Hospital, Faculty of Medicine and Pharmacy, Mohammed V-Souissi University, Rabat, Morocco.

Introduction: A variety of musculoskeletal disorders (MS) have been associated with diabetes mellitus (DM). This study aimed at assessing the prevalence and associated factors of MS disorders in Moroccan diabetic patients.

Methods: A cross-sectional study enrolled consecutive patients with DM. Read More

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http://dx.doi.org/10.1155/2018/3839872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029479PMC
June 2018
10 Reads

Long-Term Dietary Changes after Diagnosis of Rheumatoid Arthritis in Swedish Women: Data from a Population-Based Cohort.

Int J Rheumatol 2018 11;2018:9152480. Epub 2018 Jun 11.

Eugeniahemmet, T2, Karolinska Universitetssjukhuset, Solna, 17176 Stockholm, Sweden.

Objective: To investigate long-term dietary changes after rheumatoid arthritis (RA) diagnosis in Swedish women, compared to women without RA.

Methods: This study included 21,602 women from the Swedish Mammography Cohort (SMC), who completed dietary questionnaires in 1997 and 2009. Between 1997 and 2009, 191 women were diagnosed with RA. Read More

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http://dx.doi.org/10.1155/2018/9152480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016163PMC
June 2018
14 Reads

Kuwait Recommendations on Vaccine Use in People with Inflammatory Rheumatic Diseases.

Int J Rheumatol 2018 13;2018:5217461. Epub 2018 May 13.

Mubarak Al-Kabeer Hospital, Jabriya, Kuwait.

People with IRD are at increased risk of infection, and in 2011 EULAR made general recommendations for vaccination in these patients. Global and European perspectives are important, but they cannot accurately reflect the individual situations of patients in different countries and regions. Based on our clinical experience and opinions, we have sought to tailor the original EULAR recommendations to include advice for vaccination with new agents approved in the intervening years-including the new class of targeted synthetic disease-modifying antirheumatic drugs. Read More

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http://dx.doi.org/10.1155/2018/5217461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971308PMC
May 2018
5 Reads

AC-CUTE: An Open-Label Study to Evaluate Progression of Structural Joint Damage and Inflammation in Subjects with Moderate to Severe Rheumatoid Arthritis.

Int J Rheumatol 2018 12;2018:8721753. Epub 2018 Apr 12.

Cabrini Medical Centre, Malvern, VIC, Australia.

Aim: Examine the efficacy of once-weekly subcutaneous tocilizumab (SC-TCZ) on joint damage at 24 weeks based on radiography of the hands and feet and magnetic resonance imaging (MRI) of the hand in subjects with moderate to severe rheumatoid arthritis (RA).

Methods: In this Australian open-label, multicentre, prospective, single-arm study, subjects received 162 mg SC-TCZ weekly. Primary endpoint was change in radiographic Genant-modified Total Sharp Score (TSS) between baseline and Week 24. Read More

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http://dx.doi.org/10.1155/2018/8721753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925169PMC
April 2018
5 Reads

Oral Manifestations of Systemic Lupus Erythematosus Patients in Qatar: A Pilot Study.

Int J Rheumatol 2018 10;2018:6052326. Epub 2018 Apr 10.

Research Department, Weill Cornell Medicine-Qatar, P.O. Box 24144, Doha, Qatar.

Objective: The purpose of this pilot study was to assess the prevalence of oral manifestations among systemic lupus erythematosus (SLE) patients in Qatar, in order to warrant future studies that would investigate each one of these manifestations with detail and further scrutiny.

Methods: Study procedures took place between November 2014 and April 2016. All patients visiting the outpatient rheumatology clinics at Hamad General Hospital, Doha, Qatar, were asked to join. Read More

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http://dx.doi.org/10.1155/2018/6052326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914093PMC
April 2018
5 Reads

Association between Rheumatoid Arthritis and Respiratory Allergic Diseases in Korean Adults: A Propensity Score Matched Case-Control Study.

Int J Rheumatol 2018 23;2018:3798124. Epub 2018 Apr 23.

Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.

Rheumatoid arthritis (RA) and allergic diseases are result of a poor functioning immune system, giving dominance to either T-helper 1 (Th1) or T-helper 2 (Th2) diseases, respectively. Studies have stated that there seems to be a relationship present between the immune response subsets. This study was designed to examine the association between RA and respiratory allergic diseases in Korean adults. Read More

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http://dx.doi.org/10.1155/2018/3798124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937383PMC
April 2018
4 Reads

Relative Risk Chart Score for the Assessment of the Cardiovascular Risk in Young Patients with Ankylosing Spondylitis.

Int J Rheumatol 2018 15;2018:1847894. Epub 2018 Feb 15.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain.

Objective: To determine if the use of the relative risk (RR) chart score may help to identify young ankylosing spondylitis (AS) patients at high risk of cardiovascular (CV) disease.

Methods: 73 AS patients younger than 50 years were assessed. CV risk was calculated according to the total cholesterol systematic coronary risk evaluation (TC-SCORE) and the RR chart score. Read More

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http://dx.doi.org/10.1155/2018/1847894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832112PMC
February 2018
11 Reads

Effect of Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D towards Disease Activity (SLEDAI), IL-6, and TGF-1 Serum.

Int J Rheumatol 2017 28;2017:7687053. Epub 2017 Dec 28.

Clinical Pathology Department, Faculty of Medicine, Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia.

Background: Curcumin contained in is an immunomodulator that has similar biological effect as vitamin D. Combination of curcumin and vitamin D is expected to work synergistically.

Objective: To determine the effect of supplementation on vitamin D administration to SLEDAI, IL-6, and TGF-1 serum in SLE patients with hypovitamin D. Read More

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http://dx.doi.org/10.1155/2017/7687053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763117PMC
December 2017
9 Reads

The Impact of Different Classification Criteria Sets on the Estimated Prevalence and Associated Risk Factors of Diastolic Dysfunction in Rheumatoid Arthritis.

Int J Rheumatol 2017 4;2017:2323410. Epub 2017 Dec 4.

Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

This study compared the estimated prevalence and potential determinants of left ventricular (LV) diastolic dysfunction upon applying different classification criteria in rheumatoid arthritis (RA). LV diastolic function was assessed echocardiographically by pulsed Doppler (/), tissue Doppler (/', lateral and septal '), and left atrial volume index in 176 RA patients. Relationships of traditional cardiovascular risk factors and RA characteristics with LV diastolic function and dysfunction according to previous and current criteria were determined in multivariate regression models. Read More

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http://dx.doi.org/10.1155/2017/2323410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733615PMC
December 2017
10 Reads

Review of Routine Laboratory Monitoring for Patients with Rheumatoid Arthritis Receiving Biologic or Nonbiologic DMARDs.

Int J Rheumatol 2017 31;2017:9614241. Epub 2017 Oct 31.

Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Safety concerns associated with many drugs indicated for the treatment of rheumatoid arthritis (RA) can be attenuated by the early identification of toxicity through routine laboratory monitoring; however, a comprehensive review of the recommended monitoring guidelines for the different available RA therapies is currently unavailable. The aim of this review is to summarize the current guidelines for laboratory monitoring in patients with RA and to provide an overview of the laboratory abnormality profiles associated with each drug indicated for RA. Recommendations for the frequency of laboratory monitoring of serum lipids, liver transaminases, serum creatinine, neutrophil counts, and platelet counts in patients with RA were compiled from a literature search for published recommendations and guidelines as well as the prescribing information for each drug. Read More

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http://dx.doi.org/10.1155/2017/9614241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684575PMC
October 2017
15 Reads

Gastrointestinal Symptoms and Elevated Levels of Anti- Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis.

Int J Rheumatol 2017 29;2017:4029584. Epub 2017 Oct 29.

Spondyloarthropathy Group, Rheumatology Department, Hospital Militar Central, Faculty of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia.

Background: Spondyloarthritis (SpA) is a group of articular inflammatory rheumatic diseases that their gastrointestinal manifestations are around 10% of their extra-articular symptoms, supporting that the inflammatory response of the intestinal mucosa could be associated with the clinical status.

Objectives: To investigate the association between gastrointestinal symptoms and autoantibodies and disease activity between SpA patients, healthy subjects (HS), and patients with inflammatory bowel disease (IBD).

Methods: 102 SpA patients, 29 IBD patients, and 117 HS were included. Read More

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http://dx.doi.org/10.1155/2017/4029584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682082PMC
October 2017
6 Reads

Cross-Cultural Validation of Urdu Version KOOS in Indian Population with Primary Knee Osteoarthritis.

Int J Rheumatol 2017 25;2017:1206706. Epub 2017 Oct 25.

Department of Physiotherapy, CAMS, Majmaah University, Al Majmaah 11952, Saudi Arabia.

Purpose: The primary aim of this study was to translate a self-reported questionnaire (KOOS) from English to Urdu and then to see its internal consistency, agreement, test-retest reliability, and validity among primary OA knee patients.

Methodology: First, KOOS questionnaire was translated from English language to Urdu through standardized cross-cultural protocol. This translated version of KOOS was administered to 111 radiographically diagnosed primary OA knee patients at two times with 48-hour interval in-between. Read More

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http://dx.doi.org/10.1155/2017/1206706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676448PMC
October 2017
8 Reads

Incidence and Risk Factors for Infections Requiring Hospitalization, Including Pneumocystis Pneumonia, in Japanese Patients with Rheumatoid Arthritis.

Int J Rheumatol 2017 18;2017:6730812. Epub 2017 Oct 18.

Department of Rheumatology, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.

Objective: Rheumatoid arthritis (RA) may be complicated by different infections, but risk factors for these are not fully elucidated. Here, we assessed the incidence of and risk factors for infections requiring hospitalization (IRH) including pneumocystis pneumonia (PCP) in patients with RA.

Methods: We retrospectively surveyed all RA patients treated at our hospital from 2009 to 2013, for whom data were available on demographic features, medications, comorbidities, and severity of RA. Read More

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http://dx.doi.org/10.1155/2017/6730812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664349PMC
October 2017
22 Reads

Knitting the Threads of Silk through Time: Behçet's Disease-Past, Present, and Future.

Int J Rheumatol 2017 10;2017:2160610. Epub 2017 Sep 10.

Department of Rheumatology, University Hospital Limerick, Limerick, Ireland.

Behçet's disease (BD) is a chronic relapsing vasculitis that affects vessels of all types and sizes with a broad spectrum of phenotypic heterogeneity and complex immunopathogenesis. Efforts by the scientific community to resolve the unmet needs of BD and gaps in our knowledge have been hampered by considerable challenges that primarily relate to the rare nature of the disease in many parts of the world and its heterogeneity. Controversies remain in many aspects of the disease including the diagnostic criteria, immunopathogenesis and biomarker discovery, geographical variation, and therapeutic considerations. Read More

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http://dx.doi.org/10.1155/2017/2160610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610876PMC
September 2017
7 Reads

Review of Current Immunologic Therapies for Hidradenitis Suppurativa.

Int J Rheumatol 2017 20;2017:8018192. Epub 2017 Aug 20.

Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 822, Charleston, SC 29425, USA.

Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease of apocrine gland-bearing skin which affects approximately 1-4% of the population. The disease is more common in women and patients of African American descent and approximately one-third of patients report a family history. Obesity and smoking are known risk factors, but associations with other immune disorders, especially inflammatory bowel disease, are also recognized. Read More

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http://dx.doi.org/10.1155/2017/8018192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585618PMC
August 2017
25 Reads

Clinically Apparent Arterial Thrombosis in Persons with Systemic Vasculitis.

Int J Rheumatol 2017 21;2017:3572768. Epub 2017 Jun 21.

Division of Rheumatology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.

Objective: To estimate the incidence rate of clinically apparent arterial thrombotic events and associated comorbidities in patients with primary systemic vasculitis.

Methods: Using large cohort administrative data from Quebec, Canada, we identified patients with vasculitis, including polyarteritis nodosa (PAN) and granulomatosis with polyangiitis (GPA). Incident acute myocardial infarctions (AMIs) and cerebrovascular accidents (CVAs) after the diagnosis of vasculitis were ascertained in the PAN and GPA group via billing and hospitalization data. Read More

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http://dx.doi.org/10.1155/2017/3572768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497634PMC
June 2017
10 Reads

Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: "The COMORA Study".

Int J Rheumatol 2017 1;2017:5491676. Epub 2017 Jun 1.

Department of Rheumatology, Hôpital Cochin, Paris Descartes University, Assistance Publique-Hôpitaux de Paris, EULAR Center of Excellence, INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France.

The aims of this study are to evaluate vitamin D status in 1413 RA patients of COMORA study from 15 countries and to analyze relationship between patients' RA characteristics and low levels of vitamin D. All demographic, clinical, and biological data and RA comorbidities were completed. The results showed that the average of vitamin D serum dosage was 27. Read More

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http://dx.doi.org/10.1155/2017/5491676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471553PMC
June 2017
33 Reads

The CEDAR Study: A Longitudinal Study of the Clinical Effects of Conventional DMARDs and Biologic DMARDs in Australian Rheumatology Practice.

Int J Rheumatol 2017 23;2017:1201450. Epub 2017 May 23.

Menzies Institute for Medical Research, Hobart, TAS, Australia.

Objectives: To observe the choices of conventional disease modifying antirheumatic drugs (cDMARDs) and biologic DMARDs (bDMARDs) in the management of rheumatoid arthritis (RA) in Australian routine clinical practice, to assess treatment survival and determine the effect of cDMARDs/bDMARDs on disease activity.

Methods: Routinely collected, deidentified clinical data was sourced from 20 Australian rheumatology practices. RA patients aged ≥18 years, who had received cDMARDs/bDMARDs and a recorded subsequent visit, were included. Read More

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http://dx.doi.org/10.1155/2017/1201450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463140PMC
May 2017
44 Reads

The Nonradiographic Axial Spondyloarthritis, the Radiographic Axial Spondyloarthritis, and Ankylosing Spondylitis: The Tangled Skein of Rheumatology.

Int J Rheumatol 2017 7;2017:1824794. Epub 2017 May 7.

Department of Rheumatology, The Joint Disease Clinic, ISIC Superspeciality Hospital, Vasant Kunj, New Delhi 110070, India.

Since 1984 the diagnosis of ankylosing spondylitis (AS) has been based upon the modified New York (mNY) criteria with mandatory presence of radiographic sacroiliitis, without which the diagnosis is not tenable. However, it may take years or decades for radiographic sacroiliitis to develop delaying the diagnosis for long periods. It did not matter in the past because no effective treatment was available. Read More

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http://dx.doi.org/10.1155/2017/1824794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438843PMC
May 2017
29 Reads

Tofacitinib versus Biologic Treatments in Moderate-to-Severe Rheumatoid Arthritis Patients Who Have Had an Inadequate Response to Nonbiologic DMARDs: Systematic Literature Review and Network Meta-Analysis.

Int J Rheumatol 2017 9;2017:8417249. Epub 2017 Mar 9.

Pfizer Inc., Groton, CT, USA.

. To compare the efficacy and tolerability of tofacitinib, an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA), as monotherapy and combined with disease-modifying antirheumatic drugs (DMARDs) versus biological DMARDs (bDMARDs) and other novel DMARDs for second-line moderate-to-severe rheumatoid arthritis (RA) patients by means of a systematic literature review (SLR) and network meta-analysis (NMA). . Read More

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http://dx.doi.org/10.1155/2017/8417249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362710PMC
March 2017
8 Reads

Interobserver Agreement in Magnetic Resonance of the Sacroiliac Joints in Patients with Spondyloarthritis.

Int J Rheumatol 2017 13;2017:3143069. Epub 2017 Feb 13.

Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Chía, Colombia.

. Clinical, laboratory, and radiologic parameters are used for diagnosis and classification of spondyloarthritis (SpA). Magnetic resonance imaging (MRI) of sacroiliac (SI) joints is being increasingly used to detect early sacroiliitis. Read More

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http://dx.doi.org/10.1155/2017/3143069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327779PMC
February 2017
18 Reads

Hard Physical Work Intensifies the Occupational Consequence of Physician-Diagnosed Back Disorder: Prospective Cohort Study with Register Follow-Up among 10,000 Workers.

Int J Rheumatol 2017 31;2017:1037051. Epub 2017 Jan 31.

National Research Centre for the Working Environment, Copenhagen, Denmark; Physical Activity and Human Performance Group, SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.

While musculoskeletal pain is common in the population, less is known about its labor market consequences in relation to physical activity at work. This study investigates whether hard physical work aggravates the consequences of back disorder. Using Cox regression analyses, we estimated the joint association of physical activity at work and physician-diagnosed back disorder in 2010 with the risk of register-based long-term sickness absence (LTSA) of at least 6 consecutive weeks during 2011-2012 among 9,544 employees from the general working population (Danish Work Environment Cohort Study). Read More

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http://dx.doi.org/10.1155/2017/1037051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307132PMC
January 2017
10 Reads

Isolated Ro52 Antibodies as Immunological Marker of a Mild Phenotype of Undifferentiated Connective Tissue Diseases.

Int J Rheumatol 2017 22;2017:3076017. Epub 2017 Jan 22.

Immunology Unit, Central Laboratory, Complejo Hospitalario Universitario de Canarias, Tenerife, Spain.

The term undifferentiated connective tissue disease (UCTD) is used to describe undiagnosed patients that do not fulfill classification criteria for definite connective tissue disease (Systemic Lupus, Systemic Sclerosis, Sjögren Syndrome, and Dermatomyositis/Polymyositis). It is important to find serological markers as predictors of the evolution or severity of these diseases. The objective of this retrospective study was to investigate if there was a milder subgroup of UCTD with a special clinical profile consisting only in the presence of anti-Ro52 autoantibodies. Read More

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https://www.hindawi.com/journals/ijr/2017/3076017/
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http://dx.doi.org/10.1155/2017/3076017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292168PMC
January 2017
31 Reads

Physicians' Perspectives on the Diagnosis and Treatment of Chronic Nonbacterial Osteomyelitis.

Int J Rheumatol 2017 10;2017:7694942. Epub 2017 Jan 10.

Pediatrics, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, NJ, USA.

. Understanding the practices of pediatric rheumatologists in diagnosing and treating chronic nonbacterial osteomyelitis (CNO) can provide important information to guide the development of consensus treatment plans. The objectives of this study were to determine physicians' approaches to (1) diagnosing and monitoring CNO, (2) ordering a bone biopsy, and (3) making treatment decisions. Read More

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http://dx.doi.org/10.1155/2017/7694942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259599PMC
January 2017
18 Reads

Validation of Administrative Osteoarthritis Diagnosis Using a Clinical and Radiological Population-Based Cohort.

Int J Rheumatol 2016 29;2016:6475318. Epub 2016 Dec 29.

Arthritis Research Centre of Canada, 5591 No. 3 Road, Richmond, BC, Canada V6X 2C7; Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

The validity of administrative osteoarthritis (OA) diagnosis in British Columbia, Canada, was examined against X-rays, magnetic resonance imaging (MRI), self-report, and the American College of Rheumatology criteria. During 2002-2005, 171 randomly selected subjects with knee pain aged 40-79 years underwent clinical assessment for OA in the knee, hip, and hands. Their administrative health records were linked during 1991-2004, in which OA was defined in two ways: (AOA1) at least one physician's diagnosis or hospital admission and (AOA2) at least two physician's diagnoses in two years or one hospital admission. Read More

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http://dx.doi.org/10.1155/2016/6475318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227164PMC
December 2016
34 Reads

Corrigendum to "An Insight into Methods and Practices in Hip Arthroplasty in Patients with Rheumatoid Arthritis".

Int J Rheumatol 2016 27;2016:1741420. Epub 2016 Dec 27.

Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.

[This corrects the article DOI: 10.1155/2015/140143.]. Read More

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http://dx.doi.org/10.1155/2016/1741420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222995PMC
December 2016
14 Reads

Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading.

Int J Rheumatol 2016 14;2016:9525724. Epub 2016 Dec 14.

Immunology Division, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Center of Excellence in Immunology and Immune-Mediated Diseases, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Osteoarthritis is a condition of joint failure characterized by many pathologic changes of joint-surrounding tissues. Many evidences suggest the role of both innate and adaptive immunity that interplay, resulting either in initiation or in progression of osteoarthritis. Adaptive immune cells, in particular T cells, have been demonstrated to play a role in the development of OA in animal models. Read More

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http://dx.doi.org/10.1155/2016/9525724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192329PMC
December 2016
7 Reads

Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever.

Int J Rheumatol 2016 13;2016:7354018. Epub 2016 Dec 13.

Department of Rheumatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

. SAA is an acute-phase reactant detected during an FMF attack or other inflammatory conditions. High SAA levels may increase the risk of amyloidosis. Read More

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http://dx.doi.org/10.1155/2016/7354018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187476PMC
December 2016
9 Reads

Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage.

Int J Rheumatol 2016 30;2016:6432867. Epub 2016 Nov 30.

Forensic Medicine Service, Moscow City Health Department, Moscow, Russia.

This study reports the effects of the iron chelator deferoxamine (DFO) on collagen cleavage, inflammation, and chondrocyte hypertrophy in relation to energy metabolism-related gene expression in osteoarthritic (OA) articular cartilage. Full-depth explants of human OA knee articular cartilage from arthroplasty were cultured with exogenous DFO (1-50 M). Type II collagen cleavage and phospho-adenosine monophosphate-activated protein kinase (pAMPK) concentrations were measured using ELISAs. Read More

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http://dx.doi.org/10.1155/2016/6432867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155111PMC
November 2016
17 Reads

Association between Air Pollution and the Development of Rheumatic Disease: A Systematic Review.

Int J Rheumatol 2016 25;2016:5356307. Epub 2016 Oct 25.

Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

. Environmental risk factors, such as air pollution, have been studied in relation to the risk of development of rheumatic diseases. We performed a systematic literature review to summarize the existing knowledge. Read More

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http://dx.doi.org/10.1155/2016/5356307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099457PMC
October 2016
17 Reads

Impact of Anti-Inflammatory Drugs on Pyogenic Vertebral Osteomyelitis: A Prospective Cohort Study.

Int J Rheumatol 2016 19;2016:9345467. Epub 2016 Oct 19.

Infectious Diseases Unit, University Hospital of Bretonneau, Denis Diderot University, Tours, France.

. Pyogenic vertebral osteomyelitis (PVO) are frequently misdiagnosed and patients often receive anti-inflammatory drugs for their back pain. We studied the impact of these medications. Read More

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http://dx.doi.org/10.1155/2016/9345467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090101PMC
October 2016
36 Reads

Risk of Malignant Neoplasm in Patients with Incident Rheumatoid Arthritis 1980-2007 in relation to a Comparator Cohort: A Population-Based Study.

Int J Rheumatol 2016 17;2016:4609486. Epub 2016 Aug 17.

Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

Objective. To determine whether the incidence of malignancy is increased in patients with rheumatoid arthritis (RA) compared to a matched comparison cohort and to identify risk for any individual malignancy in RA. Methods. Read More

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http://dx.doi.org/10.1155/2016/4609486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005573PMC
September 2016
9 Reads

Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness.

Int J Rheumatol 2016 17;2016:6402963. Epub 2016 Jul 17.

Department of Traumatology and Orthopaedics, University of Tartu, Puusepa Street 8, 51014 Tartu, Estonia; Traumatology and Orthopaedics Clinic, Tartu University Hospital, Tartu, Estonia.

Objective. Osteoarthritis (OA) is associated with increased cardiovascular comorbidity and mortality. Evidence is lacking about whether arterial stiffness is involved in OA. Read More

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http://dx.doi.org/10.1155/2016/6402963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967435PMC
August 2016
12 Reads

Erratum to "The Characteristics and Significance of Locally Infiltrating B Cells in Lupus Nephritis and Their Association with Local BAFF Expression".

Int J Rheumatol 2016 16;2016:7513892. Epub 2016 Jun 16.

Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 145 Shan Dong Zhong Road, Shanghai 200001, China.

[This corrects the article DOI: 10.1155/2013/954292.]. Read More

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http://dx.doi.org/10.1155/2016/7513892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927994PMC
July 2016
6 Reads

Cardiac Function and Diastolic Dysfunction in Behcet's Disease: A Systematic Review and Meta-Analysis.

Int J Rheumatol 2016 10;2016:9837184. Epub 2016 May 10.

Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Background. Cardiovascular involvement in Behcet's disease (BD) is reported and has variable manifestations. It is not clear if diastolic dysfunction (DD) is increased in BD. Read More

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http://dx.doi.org/10.1155/2016/9837184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877481PMC
June 2016
10 Reads