1,787 results match your criteria International Journal of Rheumatic Diseases[Journal]


Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice.

Int J Rheum Dis 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Sciences, Rheumatology, Uppsala University, Uppsala, Sweden.

Aim: To assess predictors of alanine aminotransferase (ALT) elevation in methotrexate (MTX) treated rheumatoid arthritis (RA) patients, and to describe the monitoring of liver enzymes, including handling and outcome of elevated ALT.

Methods: All RA patients starting MTX in January, 2005 to April, 2013 at a rheumatology clinic, (Uppsala University Hospital, Sweden) were identified from electronic medical records. Clinical and laboratory data were obtained from medical records, supplemented by telephone interviews. Read More

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http://dx.doi.org/10.1111/1756-185X.13576DOI Listing

Care quality for rheumatoid arthritis patients in Quebec.

Int J Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Division of Clinical Epidemiology, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.

Aim: The aims of this study were to: (a) measure the proportion of CARTaGENE rheumatoid arthritis (RA) patients fulfilling pre-specified quality indicators (ie disease-modifying antirheumatic drug [DMARD] use, regular follow up, use of folate supplementation, use of vitamin D and calcium, exercise and smoking status); and (b) examine variation in DMARD use with respect to patient age, sex, education and income.

Methods: A cohort of RA patients was constructed based on the CARTaGENE survey and health administrative database. CARTaGENE is a large, established, population-based study which recruited 19 995 participants from four metropolitan regions in Quebec. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13
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http://dx.doi.org/10.1111/1756-185X.13580DOI Listing
April 2019
3 Reads

Aberrant expression of microRNAs in peripheral blood mononuclear cells as candidate biomarkers in patients with axial spondyloarthritis.

Int J Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Objectives: Axial spondyloarthritis (axSpA) is a chronic inflammatory arthritis involving the axial skeleton. Recent evidence suggests that microRNAs (miRNAs) play a critical role in ankylosing spondylitis (AS). In this study, we aimed to investigate whether miR-17-5p, miR-27a, miR-29a and miR-126-3p can be verified as potential biomarkers of axSpA. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13
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http://dx.doi.org/10.1111/1756-185X.13563DOI Listing
April 2019
5 Reads

Treatment with golimumab or infliximab reduces health resource utilization and increases work productivity in patients with ankylosing spondylitis in the QUO-VADIS study, a large, prospective real-life cohort.

Int J Rheum Dis 2019 Apr 15. Epub 2019 Apr 15.

Merck & Co., Inc, Kenilworth, New Jersey.

Aim: We evaluated the effects of anti-tumor necrosis factor (TNF) agents on health economics in ankylosing spondylitis (AS) patients.

Methods: QUality of Life as Outcomes and its VAriation with DIsease States (QUO-VADIS) was a prospective observational study following bio-naïve AS patients (modified New York criteria) newly treated with golimumab (GLM) or infliximab (IFX; originator) in a clinical practice setting over 6 months. We evaluated use of concomitant medications, hospitalizations (in-patient care or acute care) and visits in day care and out-patient settings for the assessment of healthcare resource utilization (HCRU). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13
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http://dx.doi.org/10.1111/1756-185X.13526DOI Listing
April 2019
3 Reads

Role of autonomic dysfunction in the regulation of myocardial blood flow in systemic sclerosis evaluated by cardiac magnetic resonance.

Int J Rheum Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Medicine, Clinical Immunology Unit-Scleroderma Center, Sapienza University of Rome, Rome, Italy.

Aim: Autonomic dysfunction (AD) is an early feature of systemic sclerosis (SSc). A regular endothelial function is a prerequisite for normal response of the myocardial blood flow (MBF) to cold pressure test (CPT). The aim of the study was to evaluate the relation between MBF and AD at rest and after CPT in asymptomatic SSc patients. Read More

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http://dx.doi.org/10.1111/1756-185X.13569DOI Listing
April 2019
1 Read

APLAR Matters.

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Int J Rheum Dis 2019 Apr;22(4):759-760

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http://dx.doi.org/10.1111/1756-185X.13577DOI Listing

Improving adherence to urate-lowering therapy in people living with gout.

Int J Rheum Dis 2019 Apr;22(4):542-544

St Vincent's Clinical School, UNSW Medicine, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/1756-185X.13566DOI Listing
April 2019
1 Read

Evaluation of subclinical atherosclerosis by ultrasound radiofrequency data technology in patients with Behçet's disease.

Int J Rheum Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Radiology, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Aim: We aimed to evaluate subclinical atherosclerosis based on carotid intima-media thickness (CIMT) and arterial stiffness measurements in patients with Behçet's disease (BD), using ultrasound (US) radiofrequency (RF) data technology.

Methods: We included 33 BD patients and 33 healthy controls in this study. The participants did not have any primary cardiovascular risk factors, such as diabetes mellitus, hypertension, hyperlipidemia and obesity. Read More

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http://dx.doi.org/10.1111/1756-185X.13579DOI Listing
April 2019
1 Read

Influence of disease duration and socioeconomic factors on the prevalence of infection and hospitalization in rheumatoid arthritis: KRAC study.

Int J Rheum Dis 2019 Apr 11. Epub 2019 Apr 11.

ChanRe Rheumatology and Immunology Centre, Bangalore, India.

Aim: The use of healthcare resources by rheumatoid arthritis (RA) patients can be related to the presence of disease, comorbid conditions, use of steroids, and the combined use of immunosuppressants. This study evaluated the risk factors associated with infection and hospitalization in RA.

Methods: This multicenter, cross-sectional study enrolled 3247 RA subjects fulfilling the 2010 American College of Rheumatology/European League Against Rheumatism criteria to examine the prevalence of hospitalization and episodes of documentable non-tubercular infections as a part of the "Karnataka rheumatoid arthritis comorbidity" study (KRAC). Read More

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http://dx.doi.org/10.1111/1756-185X.13562DOI Listing
April 2019
1 Read

Overlap myositis, a distinct entity beyond primary inflammatory myositis: A retrospective analysis of a large cohort from the REMICAM registry.

Int J Rheum Dis 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Inflammatory idiopathic myositis (IIM) comprises a heterogeneous group of systemic muscular diseases that can occur together with other connective tissue diseases (CTD), named overlap myositis (OM). The question of whether OM is a distinct entity still remains controversial.

Aim: The present study was conducted to assess the clinical and prognostic differences between patients diagnosed with OM, primary polymyositis (PM) and primary dermatomyositis (DM). Read More

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http://dx.doi.org/10.1111/1756-185X.13559DOI Listing
April 2019
1 Read

Clinical application of the dried milk spot method for measuring tocilizumab concentrations in the breast milk of patients with rheumatoid arthritis.

Int J Rheum Dis 2019 Apr 10. Epub 2019 Apr 10.

Japan Drug Information Institute in Pregnancy, National Center for Child Health and Development, Tokyo, Japan.

Aims: Tocilizumab (TCZ), a humanized anti-interleukin-6 receptor monoclonal antibody, is used to treat rheumatic diseases. There is limited information about the administration of TCZ during lactation. The dried spot method, a simple technique for processing biological samples which involves placement of a drop of specimen onto filter paper, has been used in clinical pharmacology to determine various drug concentrations. Read More

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http://dx.doi.org/10.1111/1756-185X.13557DOI Listing
April 2019
2 Reads

Mortality prediction in systemic lupus erythematosus patients with pulmonary infection.

Int J Rheum Dis 2019 Apr 10. Epub 2019 Apr 10.

Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong, China.

Objective: The impact of pulmonary infection (PI) on mortality of patients with systemic lupus erythematosus (SLE) has been established. Nevertheless, the effect of risk factors in mortality remains controversial. The objective of this study is to determine the risk factors of short-term mortality among SLE patients with PI. Read More

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http://dx.doi.org/10.1111/1756-185X.13555DOI Listing
April 2019
1 Read

Evaluation of reticulocyte hemoglobin for assessment of anemia in rheumatological disorders.

Int J Rheum Dis 2019 Apr 9. Epub 2019 Apr 9.

Department of Haematology and Clinical Pathology, Sir Ganga Ram Hospital, New Delhi, India.

Objective: The aim of this study was to evaluate the role of reticulocyte hemoglobin (Ret He) estimation in subtyping of anemia and to find the correlation of Ret He with the severity of anemia.

Methods: Ninety-four patients with rheumatic diseases with anemia were enrolled. Blood samples were taken to determine various parameters. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13
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http://dx.doi.org/10.1111/1756-185X.13567DOI Listing
April 2019
4 Reads
1.771 Impact Factor

Case study of an inborn error manifested in the elderly: A woman with adult-onset mitochondrial disease mimicking systemic vasculitis.

Int J Rheum Dis 2019 Apr 10. Epub 2019 Apr 10.

Division of Rheumatology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.

Mitochondrial diseases are a group of disorders presenting mainly during infancy due to pathological dysfunction of the mitochondrial respiratory chain. We report a case of mitochondrial disease in an elderly woman complaining of generalized myalgia. A 69-year-old woman was admitted due to fatigue, general weakness, and a drowsy mental status. Read More

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http://dx.doi.org/10.1111/1756-185X.13575DOI Listing
April 2019
1 Read

Rapid progression to end-stage renal disease in a young female with mixed immunopathological features of lupus and ANCA-associated vasculitis.

Int J Rheum Dis 2019 Apr 9. Epub 2019 Apr 9.

Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/1756-185X.13573DOI Listing
April 2019
1.771 Impact Factor

Work disability in a multi-ethnic Malaysian systemic lupus erythematosus cohort: A cross-sectional study.

Int J Rheum Dis 2019 Apr 10. Epub 2019 Apr 10.

Department of Internal Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Aim: To determine the prevalence of work disability (WD) among patients with systemic lupus erythematosus (SLE) and its associated factors.

Method: This was a cross-sectional study involving SLE patients aged 18-56 years from Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Employment history was obtained from clinical interviews. Read More

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http://dx.doi.org/10.1111/1756-185X.13572DOI Listing
April 2019
1 Read

Association between use of Chinese herbal medicine and depression risk in patients with rheumatoid arthritis: A nationwide retrospective cohort study.

Int J Rheum Dis 2019 Apr 10. Epub 2019 Apr 10.

Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Aim: Depression is a common mental disorder in rheumatoid arthritis (RA) patients and may provoke the onset of poor clinical prognoses. In view of this, whether or not the use of Chinese herbal medicines (CHMs) can alleviate the risk of depression still remains unclear. We conducted a longitudinal cohort study to evaluate the association between CHMs us and depression risk among RA patients. Read More

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http://dx.doi.org/10.1111/1756-185X.13571DOI Listing
April 2019
2 Reads

Clinical manifestations, immunological features and prognosis of Chinese pediatric systemic lupus erythematosus: A single-center study.

Int J Rheum Dis 2019 Apr 8. Epub 2019 Apr 8.

Department of Nephrology and Rheumatology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Aim: Since there are only a few reports on pediatric systemic lupus erythematosus (pSLE) in Chinese populations, therefore we retrospectively report the clinical and immunological features as well as renal outcome in Chinese pSLE.

Methods: Patients diagnosed with pSLE at Shanghai Children's Medical Center between 2001 and 2016 were evaluated and clinical data were retrospectively collected.

Results: A total of 102 pSLE patients were analyzed. Read More

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http://dx.doi.org/10.1111/1756-185X.13547DOI Listing
April 2019
1 Read

Association between PTPN22-1123G/C and susceptibility to rheumatoid arthritis: A systematic review and meta-analysis.

Int J Rheum Dis 2019 Apr 7. Epub 2019 Apr 7.

Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan, South Korea.

Background: The incidence of rheumatoid arthritis (RA) varies greatly among different ethnic groups, suggesting genetic susceptibility. The several genetic variants of protein tyrosine phosphatase, non-receptor type 22 (PTPN22-1123G/C, rs2488457) have been widely examined. We systematically evaluated the association of PTPN22-1123 and RA risk by pooling the related studies conducted in different races. Read More

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http://dx.doi.org/10.1111/1756-185X.13535DOI Listing
April 2019
1 Read

Aggressive spinal cord involvement in granulomatosis with polyangiitis.

Int J Rheum Dis 2019 Apr 4;22(4):756-758. Epub 2019 Apr 4.

Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany.

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http://dx.doi.org/10.1111/1756-185X.13561DOI Listing
April 2019
2 Reads

Progress towards universal health coverage in the context of rheumatic diseases in India.

Int J Rheum Dis 2019 Apr 4. Epub 2019 Apr 4.

Department of Clinical Immunology & Rheumatology, Christian Medical College and Hospital, Vellore, India.

Aim: This study aims to measure current situation with regard to access and financial protection towards healthcare for rheumatic diseases (RDs) in India.

Method: The first part of this study is quantitative, and uses the data generated by the 71st Round of National Sample Survey 2014, which measured self-reported morbidity, choice of provider and utilization of services and out of pocket expenditure (OOPE) incurred on healthcare services in a sample of 65 932 households and 333 104 individuals from all across India. The second qualitative part of the study was done in one sample district to understand the barriers to access and financial protection. Read More

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http://dx.doi.org/10.1111/1756-185X.13488DOI Listing
April 2019
1 Read
1.771 Impact Factor

Factors associated with patient-physician discordance in a prospective cohort of patients with psoriatic arthritis: An Asian perspective.

Int J Rheum Dis 2019 Apr 3. Epub 2019 Apr 3.

Department of Rheumatology & Immunology, Singapore General Hospital, Singapore City, Singapore.

Objectives: To evaluate factors associated with patient-physician discordance in a multiethnic Asian cohort of psoriatic arthritis (PsA) patients.

Methods: We used data from a prospective cohort of consecutive patients with PsA fulfilling the Classification Criteria for Psoriatic Arthritis, recruited from a single center in Singapore. Sociodemographic, clinical data and patient-reported outcomes were collected using a standardized protocol at baseline, 4 months, 8 months, 1 year, 2 years and 5 years. Read More

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http://dx.doi.org/10.1111/1756-185X.13568DOI Listing
April 2019
2 Reads
1.771 Impact Factor

Clinical spectrum of post-streptococcal reactive arthritis (PSRA) revisited: Juvenile versus adult-onset disease.

Int J Rheum Dis 2019 Apr 3;22(4):750-751. Epub 2019 Apr 3.

Department of Clinical Immunology and Rheumatology, Christian Medical College & Hospital, Vellore, India.

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http://dx.doi.org/10.1111/1756-185X.13524DOI Listing
April 2019
2 Reads
1.771 Impact Factor

Interleukin-32γ: Possible association with the activity and development of nephritis in patients with systemic lupus erythematosus.

Int J Rheum Dis 2019 Apr 3. Epub 2019 Apr 3.

Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Aim: Growing evidence suggests that interleukin (IL)-32 is a cytokine involved in various autoimmune diseases. We aimed to investigate whether IL-32γ is involved in systemic lupus erythematosus (SLE), particularly in patients with lupus nephritis (LN).

Method: Sera from SLE patients without LN (n = 47), LN patients (n = 19) and healthy controls (n = 10) were collected. Read More

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http://dx.doi.org/10.1111/1756-185X.13550DOI Listing
April 2019
1 Read

Vitamin D serum levels and the risk of digital ulcers in systemic sclerosis: A longitudinal study.

Int J Rheum Dis 2019 Apr 2. Epub 2019 Apr 2.

Rheumatology Unit, University of Verona, Verona, Italy.

Aim: Low levels of vitamin D (25OHD) have been found to associated with digital ulcers (DUs) in systemic sclerosis (SSc), although only cross-sectional studies have been performed. We aimed to investigate if variations in vitamin D serum levels over time affect DU in SSc.

Methods: This is a retrospective study on 65 patients. Read More

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http://dx.doi.org/10.1111/1756-185X.13554DOI Listing
April 2019
1 Read

Abatacept suppresses the telomerase activity of lymphocytes in patients with rheumatoid arthritis.

Int J Rheum Dis 2019 Apr 2. Epub 2019 Apr 2.

Department of Rheumatology, Division of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Aim: Telomere is a component of chromosomes that protects their ends from various stresses. The telomeres shorten during cell division, and their length is maintained by telomerase. The telomerase activity of lymphocytes was shown to be upregulated on lymphocyte activation, and abatacept was found to suppress the activation of T lymphocytes involved in pathogenesis of rheumatoid arthritis. Read More

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http://dx.doi.org/10.1111/1756-185X.13558DOI Listing
April 2019
1 Read

Diagnostic value of serum high-mobility group box-1 in pediatric systemic lupus erythematosus.

Int J Rheum Dis 2019 Apr 2. Epub 2019 Apr 2.

Ministry of Public Health Hospitals, Cairo, Egypt.

Background: High-mobility group box-1 (HMGB1) acts as a damage-associated molecular pattern or as an alarmin and it stimulates inflammatory and immunological activities.

Aim: We sought to investigate serum HMGB1 protein expression in patients with pediatric systemic lupus erythematosus (pSLE) in relation to the disease characteristics and activity.

Patients And Methods: This is a controlled cross-sectional study which comprised 50 children and adolescents with Systemic lupus erythematosus (SLE) and 50 age- and sex-matched healthy subjects who served as a control group. Read More

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http://dx.doi.org/10.1111/1756-185X.13556DOI Listing
April 2019
2 Reads
1.771 Impact Factor

Gout and the risk of Alzheimer's disease: A Mendelian randomization study.

Authors:
Young Ho Lee

Int J Rheum Dis 2019 Mar 28. Epub 2019 Mar 28.

Department of Rheumatology, Korea University College of Medicine, Seoul, Korea.

Objective: This study aimed to examine whether gout is causally associated with Alzheimer's disease.

Methods: I used the publicly available summary statistics datasets of three genome-wide association studies (GWASs) on gout as the exposure dataset and meta-analysis results of four GWAS datasets consisting of 17 008 cases with Alzheimer's disease and 37 154 controls of European descent as the outcome dataset. The data were subjected to 2-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. Read More

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http://dx.doi.org/10.1111/1756-185X.13548DOI Listing
March 2019
3 Reads

Association of cardiac magnetic resonance-detected myocardial abnormalities with disease characteristics and brain natriuretic peptide levels in systemic sclerosis without cardiac symptoms.

Int J Rheum Dis 2019 Mar 28. Epub 2019 Mar 28.

Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan.

Aim: This study aimed to evaluate the association between myocardial abnormalities and left ventricular (LV) geometry as assessed using cardiac magnetic resonance imaging (CMRI) in systemic sclerosis (SSc) patients without cardiac symptoms.

Methods: SSc patients without cardiac symptoms or cardiovascular risk factors underwent contrast CMRI. CMRI were assessed for structural and functional LV parameters and myocardial fibrosis based on myocardial late gadolinium enhancement (LGE). Read More

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http://dx.doi.org/10.1111/1756-185X.13540DOI Listing
March 2019
1 Read

Medication adherence and cost-related medication non-adherence in patients with rheumatoid arthritis: A cross-sectional study.

Int J Rheum Dis 2019 Apr 28;22(4):555-566. Epub 2019 Mar 28.

Monash Nursing & Midwifery, Monash University, Melbourne, Victoria, Australia.

Aim: First, to assess the clinical characteristics and medication adherence to oral rheumatoid arthritis (RA) medications in patients with RA. Second, to examine adherence determinants with a focus on the effect of medication out-of-pocket (OOP) costs on medication adherence to oral RA medications. Lastly, to examine cost-related medication non-adherence (CRN) in patients with RA. Read More

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http://dx.doi.org/10.1111/1756-185X.13549DOI Listing
April 2019
1 Read

Efficacy and safety of tofacitinib for the treatment of rheumatoid arthritis in patients from the Asia-Pacific region: Post-hoc analyses of pooled clinical study data.

Int J Rheum Dis 2019 Mar 22. Epub 2019 Mar 22.

University of Occupational and Environmental Health Japan, Kitakyushu, Japan.

Aim: We report tofacitinib efficacy and safety in Asia-Pacific patients who participated in the rheumatoid arthritis (RA) clinical development program.

Method: This post-hoc analysis included pooled data from patients with RA in the Asia-Pacific region treated with tofacitinib with/without conventional synthetic disease-modifying antirheumatic drugs in Phase (P)1, 2, 3, and long-term extension (LTE) studies (one LTE ongoing; January 2016 data-cut). Efficacy was assessed over 24 months in patients who received tofacitinib 5 (N = 397) or 10 (N = 382) mg twice daily or placebo (N = 243) in three P2 and five P3 studies. Read More

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http://dx.doi.org/10.1111/1756-185X.13516DOI Listing
March 2019
3 Reads

Urinalysis monitoring in children with Henoch-Schönlein purpura: Is it time to revise?

Int J Rheum Dis 2019 Mar 21. Epub 2019 Mar 21.

Department of Paediatric Subspecialties, Rheumatology and Immunology Service, KK Women's and Children's Hospital, Singapore, Singapore.

Objectives: To describe the natural history and risk factors of renal involvement in our Henoch-Schönlein purpura (HSP) inception cohort.

Methods: HSP patients followed at our center for at least 6 months between 1/2009-4/2017 were included. A 2-year urinalysis (UA) monitoring protocol was adopted (6 monthly and another 6 of 3 monthly UA). Read More

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http://dx.doi.org/10.1111/1756-185X.13552DOI Listing
March 2019
2 Reads

APLAR Matters.

Authors:

Int J Rheum Dis 2019 Mar;22(3):534-535

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http://dx.doi.org/10.1111/1756-185X.13546DOI Listing
March 2019
1 Read

Osteoarthritis treatment: Is it finally time to consider glucosamine seriously?

Int J Rheum Dis 2019 Mar;22(3):338-339

Rheumatologist and Head of Osteoarthritis Clinical Research, Montreal Rheumatology Institute, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1111/1756-185X.13522DOI Listing

Clinical correlates of HLA-B*27 and its subtypes in enthesitis-related arthritis variant of juvenile idiopathic arthritis in south Indian Tamil patients.

Int J Rheum Dis 2019 Mar 18. Epub 2019 Mar 18.

Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India.

Aim: The aim of the study was to assess the distribution of human leukocyte antigen (HLA)-B*27 subtypes and its correlation with disease phenotypes in children with enthesitis-related arthritis variant of juvenile idiopathic arthritis (JIA-ERA).

Method: One hundred and sixty patients (132 males, 28 females) satisfying the International League Against Rheumatism (ILAR) classification criteria for JIA-ERA were assessed and relevant demographic, clinical and radiographic data were documented. HLA-B*27 typing was done for all the patients and B*27 positive samples were subjected to high-resolution gene sequencing. Read More

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http://dx.doi.org/10.1111/1756-185X.13551DOI Listing

Combination of ultrasound power Doppler-verified synovitis and seropositivity accurately identifies patients with early-stage rheumatoid arthritis.

Int J Rheum Dis 2019 Mar 18. Epub 2019 Mar 18.

Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Aim: We conducted this retrospective study to identify objective and comprehensive diagnostic criteria for early-stage rheumatoid arthritis (RA) that are based on ultrasound (US) and serologic findings.

Method: From August 2014 to May 2016, we recruited 216 consecutive patients at Hospital 1 and 223 consecutive patients at Hospital 2 who were suspected to have RA and underwent US of bilateral hands. In the US of bilateral hands from 22 sites, the findings obtained by grayscale and power Doppler (PD) assessments were each graded on a semi-quantitative scale from 0 to 3. Read More

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http://dx.doi.org/10.1111/1756-185X.13543DOI Listing

Mycophenolic acid-induced onychomadesis: An easily ignorable adverse effect in patients with rheumatic diseases.

Int J Rheum Dis 2019 Apr 12;22(4):753-755. Epub 2019 Mar 12.

Division of Rheumatology/Immunology and Allergy, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan.

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http://doi.wiley.com/10.1111/1756-185X.13544
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http://dx.doi.org/10.1111/1756-185X.13544DOI Listing
April 2019
3 Reads

Efficacy and safety of add-on tacrolimus versus leflunomide in rheumatoid arthritis patients with inadequate response to methotrexate.

Int J Rheum Dis 2019 Mar 12. Epub 2019 Mar 12.

Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Aim: To investigate the efficacy and safety of tacrolimus (TAC) versus leflunomide (LEF) when combined with methotrexate (MTX) in rheumatoid arthritis (RA) patients.

Method: This was a 24-week multi-center, double-blind, randomized, non-inferiority study targeting RA patients with moderate to severe Disease Activity Score of 28 joints (DAS28 > 3.2) who showed inadequate response to MTX. Read More

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http://dx.doi.org/10.1111/1756-185X.13521DOI Listing
March 2019
5 Reads

Takayasu arteritis, malignant hypertension and severe left ventricular hypertrophy.

Int J Rheum Dis 2019 Mar 12. Epub 2019 Mar 12.

Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves¨ University Hospital, Granada, Spain.

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http://dx.doi.org/10.1111/1756-185X.13541DOI Listing
March 2019
1 Read

Glycoprotein 96 polymorphisms are associated with the risk of systemic lupus erythematosus: A case-control study.

Int J Rheum Dis 2019 Mar 12. Epub 2019 Mar 12.

Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Aim: To investigate the clinical implications of a genetic polymorphism in glycoprotein 96 (GP96), by analyzing the association between the genotype and haplotype of GP96 with systemic lupus erythematosus (SLE).

Method: We analyzed cell-surface expression of GP96 in peripheral blood mononuclear cells (PBMCs) and serum titer of anti-GP96 antibody of SLE patients. Single nucleotide polymorphisms and deletion mutants of GP96 were detected by two-dimensional gene scanning (TDGS). Read More

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http://dx.doi.org/10.1111/1756-185X.13515DOI Listing
March 2019
2 Reads

Apparent diffusion coefficient characteristics of parenchymal neuro-Behcet's disease.

Int J Rheum Dis 2019 Mar 12. Epub 2019 Mar 12.

Cerrahpasa Faculty of Medicine, Department of Radiology, Istanbul University, Istanbul, Turkey.

Aim: To evaluate apparent diffusion coefficient (ADC) characteristic of parenchymal neuro-Behcet's disease (NBD).

Methods: We retrospectively reviewed cranial magnetic resonance imaging (MRI) examinations of NBD patients with acute or chronic parenchymal lesions. ADC measurements of the lesions and contralateral normal brain parenchyma were performed by a consensus of two radiologists. Read More

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http://dx.doi.org/10.1111/1756-185X.13542DOI Listing

Interleukin-6 and interleukin-17 are related to depression in patients with rheumatoid arthritis.

Int J Rheum Dis 2019 Mar 7. Epub 2019 Mar 7.

Division of Allergy, Immunology, Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan.

Aim: Mood disorders are a serious issue for patients with rheumatoid arthritis (RA) because poor mental health can exacerbate the disease course. This study aimed to identify the effect of proinflammatory cytokines on the mood of patients with RA.

Methods: This study was conducted at a rheumatology clinic in Northern Taiwan. Read More

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http://dx.doi.org/10.1111/1756-185X.13529DOI Listing
March 2019
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Elevated expression of interleukin-37 in patients with rheumatoid arthritis.

Int J Rheum Dis 2019 Mar 6. Epub 2019 Mar 6.

Department of Evidence-Based Medicine, School of Public Health, Southwest Medical University, Luzhou, Sichuan, China.

Aim: This study aims to discuss plasma and messenger RNA (mRNA) levels of interleukin (IL)-37 in rheumatoid arthritis (RA) patients and evaluate the potential of plasma IL-37 as a biomarker for RA.

Method: Plasma IL-37 levels and IL-37 mRNA relative concentrations were measured by enzyme-linked immunosorbent assay (ELISA) and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). We discussed the association of IL-37 levels and clinical, laboratory parameters in RA patients in a training cohort. Read More

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http://dx.doi.org/10.1111/1756-185X.13539DOI Listing
March 2019
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Evaluation of Scleroderma Clinical Trials Consortium training recommendations on modified Rodnan skin score assessment in scleroderma.

Int J Rheum Dis 2019 Mar 6. Epub 2019 Mar 6.

Scleroderma Program, University of Michigan, Ann Arbor, Michigan.

Aim: The modified Rodnan skin score (mRSS) is a validated outcome measure for skin thickness in systemic sclerosis (SSc). Training has been shown to reduce variability in the measurement of mRSS. Our objective was to assess the inter- and intra-observer variability of mRSS scoring using the proposed recommendations for training by the Scleroderma Clinical Trials Consortium (SCTC) and World Scleroderma Foundation (WSF). Read More

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http://dx.doi.org/10.1111/1756-185X.13523DOI Listing
March 2019
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Comment on: A case of granulomatosis with polyangiitis complicated by two opportunistic infections.

Int J Rheum Dis 2019 Apr 5;22(4):752. Epub 2019 Mar 5.

Faculty of Medicine, Department of Microbiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

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http://dx.doi.org/10.1111/1756-185X.13528DOI Listing
April 2019
3 Reads

microRNA involvement in the regulation of survivin in peripheral blood mononuclear cells from rheumatoid arthritis patients.

Int J Rheum Dis 2019 Mar 5. Epub 2019 Mar 5.

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Aim: Impaired regulation of immune tolerance results in autoimmune diseases, such as rheumatoid arthritis (RA). Survivin is an anti-apoptotic protein and can induce cellular mitosis. In the current study, we assessed the transcript level of total survivin (survivin-TS) and its three major variants and evaluated the expression level of important micro RNAs (miRNAs) involved in survivin expression regulation in RA patients. Read More

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http://dx.doi.org/10.1111/1756-185X.13520DOI Listing
March 2019
1 Read
1.771 Impact Factor

Detection of subclinical synovial hypertrophy by musculoskeletal gray-scale/ power Doppler ultrasonography in systemic lupus erythematosus patients: A cross-sectional study.

Int J Rheum Dis 2019 Mar 4. Epub 2019 Mar 4.

Department of Orthopedics, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Objective: Laboratory investigations are invasive methods. Magnetic resonance imaging (MRI) has a small field of view. Ultrasound can be performed at multiple parts of the body. Read More

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http://dx.doi.org/10.1111/1756-185X.13525DOI Listing
March 2019
4 Reads

Systemic sclerosis and the risk of perioperative major adverse cardiovascular events for inpatient non-cardiac surgery.

Int J Rheum Dis 2019 Mar 4. Epub 2019 Mar 4.

Mailman School of Public Health, Columbia University Medical Center, New York, New York.

Aim: We investigated the association between systemic sclerosis (SSc) and perioperative cardiovascular risk for inpatient non-cardiac surgical procedures.

Methods: We used data from the National Inpatient Sample (NIS) for the year 2014 to identify patients undergoing inpatient non-cardiac surgery. SSc and major adverse cardiovascular events (MACE) were defined by International Classification of Diseases 9th Revision diagnosis codes. Read More

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http://dx.doi.org/10.1111/1756-185X.13537DOI Listing
March 2019
1.771 Impact Factor