4,417 results match your criteria International Journal of Radiation Biology [Journal]


Effect of cell phone radiation on neutrophil of mice.

Int J Radiat Biol 2019 Apr 23:1-22. Epub 2019 Apr 23.

a Department of Immunology , School of Elementary Medicine, North China University of Science and Technology , Tangshan , China.

Purpose The present study aims to evaluate the effect of cell phone radiation on neutrophil of mice. Materials and methods 40 male BALB/C mice were randomly broken up into 4 groups as control, blank control, TD-CDMA and LTE-Advanced groups respectively. Mice were exposed to cell phone radiation for a period of 6 weeks. Read More

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http://dx.doi.org/10.1080/09553002.2019.1607605DOI Listing

Study of Mutation from DNA to Biological Evolution.

Int J Radiat Biol 2019 Apr 23:1-42. Epub 2019 Apr 23.

a Research Center for Nuclear Physics, Osaka University , Japan.

Purpose: This is a paper based on a talk given in the BER2018 conference by M. Bando. We first emphasize the importance of collaborations among scientists in various fields for the low dose/dose-rate effects on biological body. Read More

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http://dx.doi.org/10.1080/09553002.2019.1606957DOI Listing

Comparative study of Micronucleus assays and Dicentric plus ring chromosomes for dose assessment in particular cases of partial-body exposure.

Int J Radiat Biol 2019 Apr 22:1-36. Epub 2019 Apr 22.

a Centro Regional de Ciências Nucleares do Nordeste (CRCN-NE) , 50740-545 , Recife , Brazil.

Purpose: The goal was to compare the micronucleus (MN) and dicentric plus ring chromosomes (D + R) assays for dose assessment in cases of partial body irradiations (PBI).

Materials And Methods: We constructed calibration curves for each assay at doses ranging from 0 to 5 Gy. In order to simulate partial-body exposures, blood samples from two donors were irradiated with 0. Read More

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http://dx.doi.org/10.1080/09553002.2019.1607606DOI Listing

Role of Nrf2-antioxidant in radioprotection by root extract of Inula racemosa.

Int J Radiat Biol 2019 Apr 18:1-34. Epub 2019 Apr 18.

a Division of Capacity Enhancement and Product Induction , Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization , Timarpur , Delhi , India 110054.

Purpose: Inula racemosa, a Trans-Himalayan plant is an important medicinal herb. In the present study, the radio-modulatory efficacy of aqueous root extract of I. racemosa was investigated. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1607607DOI Listing
April 2019
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Why is the multiple stressor concept of relevance to radioecology?

Int J Radiat Biol 2019 Apr 11:1-25. Epub 2019 Apr 11.

a Norwegian University of Life Sciences (NMBU), Faculty of Environmental Sciences and Natural Resource Management (MINA) , P.O. Box 5003 , N-1432 Ås , Norway.

Purpose: A number of nuclear and radiological sources have contributed or are still contributing to the release of a series of stressors such as radionuclides in combination with trace metals and even organic chemicals. To assess the impact of mixed contamination, a limited number of stressors are usually evaluated one by one. We have therefore evaluated the benefit of using the multiple stressor concept focusing on key topics within radioecology such as the source term and deposition, ecosystem interactions and exposure, biological uptake and effects including adverse outcome pathway, as a basis for assessing impact and risk. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1605463DOI Listing
April 2019
3 Reads

Utility of TRAP markers to determine indel mutation frequencies induced by gamma-ray irradiation of faba bean (Vicia faba L.) seeds.

Int J Radiat Biol 2019 Apr 9:1-33. Epub 2019 Apr 9.

a Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute , Jeongeup 56212 , Korea.

Purpose: The aims were to determine the optimal gamma ray dose for faba bean (Vicia faba) and to identify genetic variation and indel mutation frequency among mutants using target region amplification polymorphism (TRAP) markers.

Materials And Methods: Seeds from 10 elite lines were irradiated with gamma rays (50-700 Gy), and germination, survival rate, and representative morphological traits were measured. Extent of DNA damage was investigated using comet assays, and TRAP markers were used to evaluate genetic variation, genetic diversity, and mutation frequencies. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1605462DOI Listing
April 2019
4 Reads

Recent discussions toward regulatory implementation of the new occupational equivalent dose limit for the lens of the eye and related studies in Japan.

Int J Radiat Biol 2019 Apr 9:1-43. Epub 2019 Apr 9.

c Japan Atomic Energy Agency , 4-33 Muramatsu, Tokai-mura , Nakagun , Ibaraki 319-1194 , Japan.

Purpose: In 2011, the International Commission on Radiological Protection (ICRP) recommended an equivalent dose limit for the lens of the eye of 20 mSv/year, averaged over defined periods of 5 years, with no single year exceeding 50 mSv for occupational exposure in planned exposure situations. Since then, there have been extensive discussions toward regulatory implementation of such a new occupational lens dose limit. This paper provides an overview of the recent discussions toward regulatory implementation and the current status of the studies related to radiation exposure of the lens and its effect in Japan. Read More

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http://dx.doi.org/10.1080/09553002.2019.1605464DOI Listing

Autophagy suppresses radiation damage by activating PARP-1 and attenuating reactive oxygen species in hepatoma cells.

Int J Radiat Biol 2019 Apr 9:1-7. Epub 2019 Apr 9.

a Department of Radiation Biology, Institute of Radiation Medicine , Fudan University , Shanghai , China.

Purpose: To investigate the relationship between autophagy and radiation damage of human hepatoma cells and to explore the role of reactive oxygen species (ROS).

Materials And Methods: HepG2 cells were exposed to X-rays, then the protein expressions of microtubule-associated protein 1 light chain 3 (LC3) and poly ADP-ribose polymerase-1 (PARP-1) were measured by Western blot assay, the formation of autophagosomes was detected by an autophagy detection kit, the intracellular ROS level was measured by flow cytometer, and DNA damage was evaluated by the incidence of micronuclei (MN). A CCK-8 kit was used to measure the proliferation ability of irradiated cells with or without N-acetyl-l-cysteine (NAC) treatment. Read More

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http://dx.doi.org/10.1080/09553002.2019.1605461DOI Listing

Cancer stem cells in radiation response: current views and future perspectives in radiation oncology.

Int J Radiat Biol 2019 Mar 21:1-12. Epub 2019 Mar 21.

d German Cancer Research Center (DKFZ) , Heidelberg , Germany.

Purpose: Despite technological improvement and advances in biology-driven patient stratification, many patients still fail radiotherapy resulting in loco-regional and distant recurrence. Tumor heterogeneity remains a key challenge to effective cancer treatment, and reliable stratification of cancer patients for prediction of outcomes is highly important. Intratumoral heterogeneity is manifested at the different levels, including different tumorigenic properties of cancer cells. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589023DOI Listing
March 2019
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Big data in radiation biology and epidemiology; an overview of the historical and contemporary landscape of data and biomaterial archives.

Int J Radiat Biol 2019 Mar 19:1-18. Epub 2019 Mar 19.

b Bundesamt fuer Strahlenschutz , Neuherberg , Germany.

Over the past 60 years a great number of very large datasets have been generated from the experimental exposure of animals to external radiation and internal contamination. This accumulation of 'big data' has been matched by increasingly large epidemiological studies from accidental and occupational radiation exposure, and from plants, humans and other animals affected by environmental contamination. We review the creation, sustainability and reuse of this legacy data, and discuss the importance of Open data and biomaterial archives for contemporary radiobiological sciences, radioecology and epidemiology. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589026DOI Listing

Reflections on the Coming Year: IJRB 2019.

Int J Radiat Biol 2019 Feb;95(2):97-98

a International Journal of Radiation Biology Department of Radiation Oncology , Northwestern University , Chicago IL 60611.

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http://dx.doi.org/10.1080/09553002.2019.1574504DOI Listing
February 2019

Harnessing epigenetics and metabolism to modulate tissue response to radiotherapy.

Int J Radiat Biol 2019 Apr 11;95(4):379-381. Epub 2019 Mar 11.

b Department of Radiation Oncology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.

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http://dx.doi.org/10.1080/09553002.2019.1587268DOI Listing

Peggy Louise Olive 1948-2018.

Int J Radiat Biol 2019 Mar 5:1-2. Epub 2019 Mar 5.

d Princess Margaret Research Institute , Toronto , Canada.

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http://dx.doi.org/10.1080/09553002.2019.1590662DOI Listing

Radioprotective effects of mistletoe extract in zebrafish embryos in vivo.

Int J Radiat Biol 2019 Mar 5:1-10. Epub 2019 Mar 5.

d Department of Radiation Oncology , Korea University Anam Hospital , Seoul , Republic of Korea.

Introduction: Radioprotectors can enhance the efficacy of cancer radiotherapy, but their clinical use remains uncommon. The present study aimed to assess the radioprotective potential of mistletoe extract (commercial name: Abnoba Viscum), a well-known complementary cancer medicine, in zebrafish larvae.

Materials And Methods: Wild-type AB zebrafish embryos at 4 h-post-fertilization were exposed to 5 Gy 9-MeV electron beam irradiation after being treated for 1 h with 4 mMl/L amifostine or 0. Read More

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http://dx.doi.org/10.1080/09553002.2019.1590661DOI Listing
March 2019
2 Reads

Proliferation saturation index in an adaptive Bayesian approach to predict patient-specific radiotherapy responses.

Int J Radiat Biol 2019 Mar 4:1-6. Epub 2019 Mar 4.

a Department of Integrated Mathematical Oncology , H. Lee Moffitt Cancer Center & Research Institute , Tampa , FL , USA.

Purpose: Radiotherapy prescription dose and dose fractionation protocols vary little between individual patients having the same tumor grade and stage. To personalize radiotherapy a predictive model is needed to simulate radiation response. Previous modeling attempts with multiple variables and parameters have been shown to yield excellent data fits at the cost of non-identifiability and clinically unrealistic results. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589013DOI Listing
March 2019
2 Reads

The Million Person Study relevance to space exploration and mars.

Authors:
John D Boice

Int J Radiat Biol 2019 Mar 4:1-9. Epub 2019 Mar 4.

a National Council on Radiation Protection and Measurements , Bethesda , MD , USA.

Understanding the health consequences of exposure to radiation received gradually over time is critically needed. The National Aeronautics and Space Administration (NASA) bases its safety standards on the acute exposures received by Japanese atomic bomb survivors. Such a brief exposure differs appreciably from the chronic radiation received during a two to three year mission to Mars. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589020DOI Listing
March 2019
7 Reads

Icariin protects against radiation-induced mortality and damage in vitro and in vivo.

Int J Radiat Biol 2019 Mar 4:1-9. Epub 2019 Mar 4.

a Information-Based Drug Research Center , Korea Research Institute of Chemical Technology , Daejeon , Republic of Korea.

Purpose: The present study aimed to investigate the potential protective effects of icariin both in vivo and in vitro, an active flavonoid glucoside derived from medicinal herb Epimedium, and its possible mechanisms against radiation-induced injury.

Methods: Male C57BL/6 mice were exposed to lethal dose (7 Gy) or sub-lethal dose (4 Gy) of whole body radiation by X-ray at a dose rate of ∼0.55 Gy/min, and icariin was given three times at 24 h and 30 min before and 24 h after the irradiation. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589021DOI Listing
March 2019
6 Reads

Cardiovascular and growth outcomes of C57Bl/6J mice offspring exposed to maternal stress and ionizing radiation during pregnancy.

Int J Radiat Biol 2019 Mar 4:1-9. Epub 2019 Mar 4.

a Department of Biology , McMaster University , Hamilton , ON , Canada.

Purpose: Developmental programming involves an adverse intrauterine environment which can result in offspring phenotype changes following birth. The developmental programming of hypertension has been reported to possibly involve oxidative stress at the cellular level. Ionizing radiation produces oxidative stress, even at low doses, and irradiation of animals is often coupled with potential sources of maternal stress such as transportation of animals or repeated handling. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589025DOI Listing
March 2019
2 Reads

Radiation protection biology then and now.

Int J Radiat Biol 2019 Mar 4:1-10. Epub 2019 Mar 4.

a Centre for Radiation Protection Research, Department of Molecular Biosciences , The Wenner-Gren Institute, Stockholm University , Stockholm , Sweden.

Purpose: Radiation biology is a branch of the radiation research field which focuses on studying radiation effects in cells and organisms. Radiation can be used in biological investigations for two, mutually non-exclusive reasons: (1) to study biological processes by perturbing their functioning (qualitative approach) and (2) to assess consequences of radiation-induced damage (quantitative approach). While the former approach has a basic research character, the latter has an applied character that is driven by needs of medical applications and radiological protection. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589027DOI Listing
March 2019
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The Million Person Study, whence it came and why.

Int J Radiat Biol 2019 Mar 4:1-14. Epub 2019 Mar 4.

e Oak Ridge Associated Universities , Oak Ridge , TN , USA.

Purpose: The study of low dose and low-dose rate exposure is of immeasurable value in understanding the possible range of health effects from prolonged exposures to radiation. The Million Person Study (MPS) of low-dose health effects was designed to evaluate radiation risks among healthy American workers and veterans who are more representative of today's populations than are the Japanese atomic bomb survivors exposed briefly to high-dose radiation in 1945. A million persons were needed for statistical reasons to evaluate low-dose and dose-rate effects, rare cancers, intakes of radioactive elements, and differences in risks between women and men. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589015DOI Listing
March 2019
3 Reads

Long-term exposure of cockroach Blaptica dubia (Insecta: Blaberidae) nymphs to magnetic fields of different characteristics: effects on antioxidant biomarkers and nymphal gut mass.

Int J Radiat Biol 2019 Mar 1:1-9. Epub 2019 Mar 1.

a Department of Insect Physiology and Biochemistry , Institute for Biological Research "Siniša Stanković", University of Belgrade , Belgrade , Serbia.

Purpose: The main goal of this study was to analyze the long-term effects of static (SMF) and extremely low-frequency magnetic field (ELF MF) on nymphal gut mass and antioxidant biomarkers in this tissue of cockroach Blaptica dubia.

Materials And Methods: One-month-old nymphs were exposed to magnetic field (MF) for 5 months in three experimental groups: control, exposure to SMF (110 mT) and exposure to ELF MF (50 Hz, 10 mT).

Results: The gut masses of the MF groups were significantly lower when compared to control. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589017DOI Listing

Effect of cobalt-60 gamma radiation on total hemocyte content and biochemical parameters in Macrobrachium rosenbergii (De Man, 1879).

Int J Radiat Biol 2019 Mar 1:1-11. Epub 2019 Mar 1.

e Nuclear Agriculture and Biotechnology Division , Bhabha Atomic Research Center , Mumbai , India.

Purpose: The effect of low level cobalt-60 (Co) gamma radiation on the freshwater prawn Macrobrachium rosenbergii was evaluated by observing their hemocyte counts and biochemical parameters.

Materials And Methods: Prawns were exposed to 3, 30, 300 and 3000 milligray (mGy) dose levels and their tissues of gills, hepatopancreas and muscle were analyzed.

Results: The results showed that the number of hemocytes in the hemolymph and concentrations of protein and carbohydrate were significantly reduced in irradiated groups than compared to the control prawn. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589014DOI Listing
March 2019
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Saving normal tissues - a goal for the ages.

Int J Radiat Biol 2019 Mar 1:1-16. Epub 2019 Mar 1.

b Department of Environmental Medicine , University of Rochester Medical Center , Rochester , NY , USA.

Almost since the earliest utilization of ionizing radiation, many within the radiation community have worked toward either preventing (i.e. protecting) normal tissues from unwanted radiation injury or rescuing them from the downstream consequences of exposure. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589654DOI Listing

Combination of static magnetic field and cisplatin in order to reduce drug resistance in cancer cell lines.

Int J Radiat Biol 2019 Mar 1:1-8. Epub 2019 Mar 1.

a Toxicology Research Center and Department of Toxicology , School of Pharmacy and, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

Purpose: In this study, the effects of different intensities of Static Magnetic Fields (SMFs) (10, 15 and 25 mT) and different concentrations of cisplatin drug were investigated on the viability percent and IC of the A2780 and A2780-CP cell lines at 24, 48 and 96 h to show useful potential of SMF as a physical agent to enhance the effectiveness of common therapeutic approaches and decrease of drug resistance to cisplatin anticancer drug.

Materials And Methods: Magnetic field exposure was performed using a locally designed generator. The cell viability percent, IC and cisplatin uptake in treated cells were evaluated by MTT assay and inductively coupled plasma (ICP), respectively. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589012DOI Listing

A small fish model for quantitative analysis of radiation effects using visualized thymus responses in GFP transgenic medaka.

Int J Radiat Biol 2019 Mar 1:1-6. Epub 2019 Mar 1.

a National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , Inage-ku , Chiba , Japan.

Purpose: The aim of this study was to establish a new method of real-time, in vivo detection of radiation damage and recovery.

Methods: The thymus was observed under fluorescent light in a green fluorescent protein transgenic medaka. After irradiation, medaka thymus images were analyzed to quantify the effects of radiation by measuring changes in thymus size. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589019DOI Listing

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression.

Int J Radiat Biol 2019 Mar 1:1-8. Epub 2019 Mar 1.

a Department of Radiation Oncology , Tumor Pathophysiology Group, University Medical Center , Mainz , Germany.

In the early 1920s, Warburg published experimental data on the enhanced conversion of glucose to pyruvate (followed by lactate formation) even in the presence of abundant oxygen (aerobic glycolysis, Warburg effect). He attributed this metabolic trait to a respiratory injury and considered this a universal metabolic alteration in carcinogenesis. This interpretation of the data was questioned since the early 1950s. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589653DOI Listing
March 2019
5 Reads

Effects of gamma radiation (γ) on biochemical and antioxidant properties in black gram (Vigna mungo L. Hepper).

Int J Radiat Biol 2019 Mar 1:1-9. Epub 2019 Mar 1.

a Department of Botany, Division of Crop Mutation and Molecular Breeding , School of Life Sciences, Periyar University , Salem , Tamil Nadu , India.

Purpose: The present study focused on the role of primary metabolites, antioxidant activities in black gram (Vigna mungo L. Hepper) variety Vamban-4 under the impact of gamma irradiation.

Materials And Methods: The black gram seeds were irradiated at a different dose of gamma rays viz. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589022DOI Listing
March 2019
1 Read

Correlation between expression of CatSper1,2 and sperm parameters in the gamma irradiated adult mouse testis.

Int J Radiat Biol 2019 Mar 1:1-6. Epub 2019 Mar 1.

j Department of Medical Education , Brighton & Sussex Medical School, Falmer , Brighton , UK.

Propose: CatSper protein channels are responsible for the entry of Ca2+ into sperm cells. These proteins play an important role in motility and male fertility. So it is important to find out whether or not environmental factors, such as gamma radiation, have an effect on the expression of Catsper genes. Read More

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http://dx.doi.org/10.1080/09553002.2019.1552372DOI Listing
March 2019
1 Read

Direct and bystander effects in human blood lymphocytes exposed to Am alpha particles and the relative biological effectiveness using chromosomal aberration and micronucleus assay.

Int J Radiat Biol 2019 Mar 1:1-12. Epub 2019 Mar 1.

a Department of Human Genetics , Sri Ramachandra Institute of Higher Education and Research , Chennai , India.

Purpose: It is important to understand the significance of alpha (α) radiation-induced bystander effects (RIBE) and its relative biological effectiveness (RBE); this is because the phenomenon is not universal and the mechanism is unclear and because the RBE is widely varying and projected to be very high.

Materials And Methods: Isolated lymphocytes from healthy volunteers (n = 10) were exposed to either low fluence α-particles (Am), γ-rays (Co), or X-rays (225 kVp and 6 MV). Co-culture methodology was employed to investigate bystander effects (BEs). Read More

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http://dx.doi.org/10.1080/09553002.2019.1589018DOI Listing
March 2019
2 Reads

Targets, pools, shoulders, and communication - a reflection on the evolution of low-dose radiobiology.

Int J Radiat Biol 2019 Mar 1:1-10. Epub 2019 Mar 1.

a Department of Biology , McMaster University , Hamilton , ON , Canada.

This reflection aims to look at the evolution of thinking about radiation dose response relationships from the early years of the journal when target theory prevailed to the present day when dose response is seen as a more holistic process involving multiple levels of organization and communication. The review is structured to consider how the old ideas evolved leading to apparently abrupt paradigm shifts. The odd data leading to these conceptual shifts are reviewed. Read More

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http://dx.doi.org/10.1080/09553002.2019.1589016DOI Listing
March 2019
2 Reads

Cohort profile - MSK radiation workers: a feasibility study to establish a deceased worker sub-cohort as part of a multicenter medical radiation worker component in the million person study of Low-Dose radiation health effects.

Int J Radiat Biol 2019 Feb 27:1-7. Epub 2019 Feb 27.

b Department of Epidemiology & Biostatistics , Memorial Sloan Kettering Cancer Center , New York , NY , USA.

Background: The National Council on Radiation Protection and Measurements (NCRP) is coordinating an expansive epidemiologic effort entitled the Million Person Study of Low-Dose Radiation Health Effects (MPS). Medical workers constitute the largest occupational radiation-exposed group whose doses are typically received gradually over time.

Methods: A unique opportunity exists to establish an Institutional Review Board/Privacy Board (IRB/PB) approved, retrospective feasibility sub-cohort of diseased Memorial Sloan Kettering Cancer Center (MSK) medical radiation workers to reconstruct occupational/work history, estimate organ-specific radiation absorbed doses, and review existing publicly available records for mortality from cancer (including leukemia) and other diseases. Read More

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http://dx.doi.org/10.1080/09553002.2019.1587194DOI Listing
February 2019

Exploring the legacy and impact of historical IJRB articles and contributions to ICRP publications and Radiation Research articles through graphical reference mapping.

Int J Radiat Biol 2019 Feb 26:1-48. Epub 2019 Feb 26.

b Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI) , Tokyo , Japan.

The International Journal of Radiation Biology (IJRB) celebrates its sixtieth birthday this year. Ahead of this very special issue, we wanted to produce strong representations of the journal's publication history in order to celebrate the current status of the journal and to look forward to its future. This was accomplished using "reference maps". Read More

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http://dx.doi.org/10.1080/09553002.2019.1587195DOI Listing
February 2019

Long-term immune effects of high-level natural radiation on Yangjiang inhabitants in China.

Int J Radiat Biol 2019 Mar 19:1-7. Epub 2019 Mar 19.

b Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention , Beijing , China.

Purpose: Low dose radiation was found to perturb immune function or inflammatory reactions, which required further study. This study aimed to evaluate the health effects following long-term low dose radiation by detecting levels of peripheral blood lymphocyte subsets and serum cytokines of residents living in the Yangjiang High Background Radiation Area (HBRA).

Materials And Methods: Flow cytometry was used to detect peripheral blood T lymphocytes and its subsets (CD4 T, CD8 T lymphocyte) in 100 healthy female residents selected from HBRA and a Control Area (CA), respectively. Read More

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http://dx.doi.org/10.1080/09553002.2019.1572250DOI Listing
March 2019
5 Reads

Radiation-induced DNA damage response and resistance in colorectal cancer stem-like cells.

Int J Radiat Biol 2019 Feb 12:1-13. Epub 2019 Feb 12.

a Molecular Stress and Stem Cell Biology Group, School of Biotechnology, KIIT University , Bhubaneswar , India.

Purpose: Radiation therapy is an integral part of current treatment modality for colorectal cancer. Recent studies have revealed the presence of cancer stem-like cells (CSCs) population, in different tumors are responsible for therapeutic resistance and disease relapse, including colorectal cancer with poorer survival rate. Hence, characterization of the effect of Ionizing Radiation (IR) in colorectal cancer may serve to explain possible mechanisms. Read More

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http://dx.doi.org/10.1080/09553002.2019.1580401DOI Listing
February 2019
6 Reads

Mapping the research trends on the biological effects of radiation less than 100 mSv: A bibliometric analysis for 30 years publication.

Int J Radiat Biol 2019 Feb 12:1-28. Epub 2019 Feb 12.

a Laboratory of Low Dose Risk Assessment , National Radiation Emergency Medical Center, Korea Institute of Radiological & Medical Sciences , 01812 , Seoul , Korea.

Purpose: The purpose of this study is to evaluate the global scientific publication of biological research of low dose radiation for the past 30 years and provide the insights into the characteristics of research activities and major topics regarding to biological effects of low dose radiation exposure.

Materials And Methods: We bibliometrically investigated the biological research publication of radiation exposure less than 100 mSv. References published from 1987 to 2016 were achieved from the Scopus database and filtered by several criteria such as publication types, research fields, and radiation dose range. Read More

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http://dx.doi.org/10.1080/09553002.2019.1552373DOI Listing
February 2019

G2-lymphocyte chromosomal radiosensitivity in patients with LPS responsive beige-like anchor protein (LRBA) deficiency.

Int J Radiat Biol 2019 Feb 4:1-11. Epub 2019 Feb 4.

b Research Center for Immunodeficiencies, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.

Lipopolysaccharide-responsive, beige-like anchor protein (LRBA) deficiency is an autosomal recessive primary immunodeficiency disease characterized by a CVID-like phenotype, particularly severe autoimmunity and inflammatory bowel disease. This study was undertaken to evaluate radiation sensitivity in 11 LRBA-deficient patients. Therefore, stimulated lymphocytes of the studied subjects were exposed to a low dose γ-radiation (100 cGy) in the G phase of the cell cycle and chromosomal aberrations were scored. Read More

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http://dx.doi.org/10.1080/09553002.2019.1577570DOI Listing
February 2019
1 Read
1.837 Impact Factor

Applying a multiscale systems biology approach to study the effect of chronic low-dose exposure to uranium in rat kidneys.

Int J Radiat Biol 2019 Feb 4:1-16. Epub 2019 Feb 4.

a Institut de Radioprotection et de Sûreté Nucléaire, PSE-SANTE, SESANE, LRTOX , Fontenay-aux-Roses , France.

Purpose: To examine the effects of low-dose exposure to uranium with a systems biology approach, a multiscale high-throughput multi-omics analysis was applied with a protocol for chronic exposure to the rat kidney.

Methods: Male and female rats were contaminated for nine months through their drinking water with a nontoxic solution of uranyl nitrate. A multiscale approach enabled clinical monitoring associated with metabolomic and transcriptomic (mRNA and microRNA) analyses. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
Publisher Site
http://dx.doi.org/10.1080/09553002.2019.1577567DOI Listing
February 2019
20 Reads
1.837 Impact Factor

Quantification of DNA damage in patients undergoing non-contrast and contrast enhanced whole body PET/CT investigations using comet assay and micronucleus assay.

Int J Radiat Biol 2019 Feb 1:1-9. Epub 2019 Feb 1.

b Department of Biotechnology , Maulana Abul Kalam Azad University of Technology , Kolkata , India.

Objective: To quantify DNA damage in patients undergoing non-contrast and contrast-enhanced F-FDG PET/CT whole body positron emission tomography/computed tomography (WB PET/CT) investigations using comet assay technique and micronucleus assay, and to study the effect of other baseline parameters of patients on DNA damage.

Methodology: Eighty-four patients referred for F-FDG PET/CT investigation were included in the study of which 44 patients underwent contrast-enhanced WB PET/CT and 40 patients underwent non-contrast WB PET/CT investigations. The investigations were performed on Discovery 690 PET/CT. Read More

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http://dx.doi.org/10.1080/09553002.2019.1577569DOI Listing
February 2019
3 Reads

Is stereotactic body radiotherapy for ultra-central lung tumor a feasible option? A systemic review and meta-analysis.

Int J Radiat Biol 2019 Mar 11;95(3):329-337. Epub 2019 Feb 11.

d Department of Radiation Oncology , Guro Hospital Korea University Medical College , Seoul , Republic of Korea.

Introduction: Ultra-central (UC) tumors, which are generally defined as tumors directly abutting the proximal bronchial tree, are difficult to treat with stereotactic body radiotherapy (SBRT) owing to possible serious complications. This systemic review and meta-analysis analyzed the early experiences and evaluated the efficacy and feasibility of SBRT for UC tumors.

Methods And Materials: The present study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

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http://dx.doi.org/10.1080/09553002.2019.1552375DOI Listing
March 2019
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Epidemiological studies of atomic bomb radiation at the Radiation Effects Research Foundation.

Int J Radiat Biol 2019 Jan 24:1-13. Epub 2019 Jan 24.

e Associate Chief of Research, Radiation Effects Research Foundation , Hiroshima , Japan.

Epidemiological studies of people who were exposed to atomic bomb radiation and their children who were conceived after parental exposure to radiation (F) have investigated late health effects of atomic bomb radiation and its transgenerational effects. Those studies were initiated by the Atomic Bomb Casualty Commission (ABCC) in the 1950s. ABCC was reorganized to the Radiation Effects Research Foundation (RERF) in 1975, which continued the work of the ABCC. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1569778DOI Listing
January 2019
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Differential radio-adaptive responses in BALB/c and C57BL/6 mice: pivotal role of calcium and nitric oxide signalling.

Int J Radiat Biol 2019 Jan 24:1-12. Epub 2019 Jan 24.

a Immunology Section, Radiation Biology & Health Sciences Division , Bio-Science Group, Bhabha Atomic Research Centre , Mumbai , India.

Purpose: Our earlier studies demonstrated that transient radio-adaptive responses (RAR) in BALB/c mice were due to MAPK hyperactivation. The objective of this study was to determine the time duration of this low dose induced MAPK activation in BALB/c mice and to find out if similar adaptive responses are observed in C57BL/6 mice.

Materials And Methods: Mice were irradiated with 0. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1571647DOI Listing
January 2019
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International coordination of research: EPRI International Dose Effect Alliance.

Authors:
Donald A Cool

Int J Radiat Biol 2019 Jan 24:1-3. Epub 2019 Jan 24.

a Electric Power Research Institute , Charlotte , NC , USA.

Purpose: The key to increasing our understanding of low dose effects of ionizing radiation is cooperation and communication between research organizations around the world. The purpose of this article is to describe the Electric Power Research Institute (EPRI) program for such cooperation.

Materials And Methods: EPRI is an independent, non-profit organization dedicated to research support for the generation, transmission, and utilization of electricity. Read More

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http://dx.doi.org/10.1080/09553002.2019.1569770DOI Listing
January 2019

Ionizing radiation affects miRNA composition in both young and old mice.

Int J Radiat Biol 2019 Jan 24:1-10. Epub 2019 Jan 24.

a Radiobiology and Health, Canadian Nuclear Laboratories , Chalk River , Ontario , Canada.

Purpose: Humans are exposed to both natural (e.g. soil, cosmic rays) and human-made radiation sources (e. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1569771DOI Listing
January 2019
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History of radiation genetics: light and darkness.

Authors:
Nori Nakamura

Int J Radiat Biol 2019 Jan 24:1-16. Epub 2019 Jan 24.

a Department of Molecular Biosciences , RERF , Hiroshima , Japan.

Purpose: To review the history of radiation effects in germ cells and to attempt to discern future directions.

Materials And Methods: Review of published papers.

Results: Recent mouse studies using microarray-based comparative genomic hybridization techniques revealed that germline mutations would occur much less frequently than would be expected from the results of past studies which used specific locus tests. Read More

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http://dx.doi.org/10.1080/09553002.2019.1572251DOI Listing
January 2019

Radiation databases and archives - examples and comparisons.

Int J Radiat Biol 2019 Jan 24:1-12. Epub 2019 Jan 24.

a Feinberg School of Medicine, Radiation Oncology , Northwestern University , Chicago , IL , USA.

Studies of ionizing radiation effects through the archiving of data began with standardizing medical treatments in the early 1900s shortly after the discovery of X-rays. Once the breadth of the delayed effects of ionizing radiation was recognized, the need for long-term follow up became apparent. There are now many human archives of data from nuclear disasters and accidents, occupational exposures, and medical procedures. Read More

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http://dx.doi.org/10.1080/09553002.2019.1572249DOI Listing
January 2019
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Infrared spectroscopic demonstration of magnetic orientation in SH-SY5Y neuronal-like cells induced by static or 50 Hz magnetic fields.

Int J Radiat Biol 2019 Jan 22:1-7. Epub 2019 Jan 22.

a Department of Mathematical and Informatics Sciences , Physical Sciences and Earth Sciences, University of Messina , Messina , Italy.

Purpose: To study the response of neuronal-like cells to an applied static or low-frequency magnetic field.

Materials And Methods: Fourier Transform Infrared (FTIR) Spectroscopy was used to investigate the overall behavior of SH-SY5Y neuronal-like cells exposed to a static or 50 Hz magnetic fields at intensities up to 1 mT generated by two Helmholtz coils driven by direct current or alternate current voltage. The Helmholtz coils were placed into an incubator in a 5% CO/95% air humidified at 37 °C. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1571256DOI Listing
January 2019
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Chronic low dose exposure of hospital workers to ionizing radiation leads to increased micronuclei frequency and reduced antioxidants in their peripheral blood lymphocytes.

Int J Radiat Biol 2019 Jan 22:1-15. Epub 2019 Jan 22.

c Department of Biotechnology , Mizoram University , Aizawl , India.

Purpose: The regular low dose occupational exposure to ionizing radiation may induce deleterious health effects, which may be of particular interest to medical radiation workers who daily handle X-ray machines. Human peripheral blood lymphocytes are able to retain the signature of radiation-induced DNA damage, therefore, the present study was undertaken to investigate the DNA damage and antioxidants status in hospital workers occupationally exposed to low doses of X-rays.

Materials And Methods: The peripheral blood lymphocytes of the occupationally exposed and control groups matched for age, gender, tobacco usage, and alcohol consumption were cultured and micronuclei frequency was determined. Read More

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http://dx.doi.org/10.1080/09553002.2019.1571255DOI Listing
January 2019

Neutrons are forever! Historical perspectives.

Int J Radiat Biol 2019 Jan 22:1-28. Epub 2019 Jan 22.

a MRC Harwell Institute , Didcot , UK.

Purpose: Neutrons were an active field of radiobiology at the time of publication of the first issues of the International Journal of Radiation Biology in 1959. Three back-to-back papers published by Neary and his colleagues contain key elements of interest at the time. The present article aims to put these papers into context with the discovery of the neutron 27 years previously and then give a feel for how the field has progressed to the present day. Read More

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http://dx.doi.org/10.1080/09553002.2019.1569782DOI Listing
January 2019
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Chemical radiosensitizers: the Journal history.

Authors:
John E Moulder

Int J Radiat Biol 2019 Jan 18:1-5. Epub 2019 Jan 18.

a Radiation Oncology , Medical College of Wisconsin , Milwaukee , WI , USA.

Purpose: To review the Journal's coverage of chemical radiosensitizers.

Methods: I have reviewed all the possibly-relevant papers that appeared in the Journal prior to 1970 and since 2010, plus the most highly-cited papers from the intervening years. I excluded papers that dealt only with oxygen as a sensitizer, that referred to sensitization of phototoxicity or hyperthermia, or that described interactions with antineoplastic agents unless they clearly distinguish between additive toxicity and radiosensitization. Read More

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http://dx.doi.org/10.1080/09553002.2019.1569779DOI Listing
January 2019
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Updated mortality analysis of the Mallinckrodt uranium processing workers, 1942-2012.

Int J Radiat Biol 2019 Jan 17:1-21. Epub 2019 Jan 17.

g National Council on Radiation Protection and Measurements , Bethesda , MD , USA.

Purpose: Mallinckrodt Chemical Works (MCW) was the earliest uranium processing facility in the United States, and in 1942 produced the uranium oxide used for the first sustained and controlled nuclear fission chain-reaction at the University of Chicago. A second follow-up through 2012 was conducted of 2514 White male workers employed 1942-1966 at the MCW for dose-response analyses for selected causes of death.

Materials And Methods: Organ/tissue-specific dose reconstruction included both external (12,686 MCW film badge records, 210 other facility film badge records, and 31,297 occupational chest x-rays) and internal sources of uranium and radium (39,451 urine bioassays, 2341 breath radon measurements, and 6846 ambient radon measurements). Read More

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http://dx.doi.org/10.1080/09553002.2019.1569773DOI Listing
January 2019
5 Reads