4,385 results match your criteria International Journal of Radiation Biology [Journal]


Long-term immune effects of high level natural radiation on Yangjiang inhabitants in China.

Int J Radiat Biol 2019 Feb 12:1-15. Epub 2019 Feb 12.

b Key Laboratory of Radiological Protection and Nuclear Emergency , China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention , Beijing 100088 , China.

Purpose: Low dose radiation was found to perturb immune function or inflammatory reactions, which required further study. This study aimed to evaluate the health effects following long-term low dose radiation by detecting levels of peripheral blood lymphocyte subsets and serum cytokines of residents living in the Yangjiang High Background Radiation Area (HBRA).

Materials And Methods: Flow cytometry was used to detect peripheral blood T lymphocytes and its subsets (CD4 T, CD8 T lymphocyte) in 100 healthy female residents selected from HBRA and a Control Area (CA), respectively. Read More

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http://dx.doi.org/10.1080/09553002.2019.1572250DOI Listing
February 2019

Radiation induced DNA damage response and resistance in colorectal cancer stem-like cells.

Int J Radiat Biol 2019 Feb 12:1-23. Epub 2019 Feb 12.

a Molecular Stress and Stem Cell Biology Group , School of Biotechnology, KIIT University , Bhubaneswar , Odisha - 751024 , India.

Purpose: Radiation therapy is an integral part of current treatment modality for colorectal cancer. Recent studies have revealed the presence of cancer stem-like cells (CSCs) population, in different tumors are responsible for therapeutic resistance and disease relapse, including colorectal cancer with poorer survival rate. Hence, characterization of effect of Ionizing Radiation (IR) in colorectal cancer may serve to explain possible mechanisms. Read More

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http://dx.doi.org/10.1080/09553002.2019.1580401DOI Listing
February 2019

Mapping the research trends on the biological effects of radiation less than 100 mSv: A bibliometric analysis for 30 years publication.

Int J Radiat Biol 2019 Feb 12:1-28. Epub 2019 Feb 12.

a Laboratory of Low Dose Risk Assessment , National Radiation Emergency Medical Center, Korea Institute of Radiological & Medical Sciences , 01812 , Seoul , Korea.

Purpose: The purpose of this study is to evaluate the global scientific publication of biological research of low dose radiation for the past 30 years and provide the insights into the characteristics of research activities and major topics regarding to biological effects of low dose radiation exposure.

Materials And Methods: We bibliometrically investigated the biological research publication of radiation exposure less than 100 mSv. References published from 1987 to 2016 were achieved from the Scopus database and filtered by several criteria such as publication types, research fields, and radiation dose range. Read More

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http://dx.doi.org/10.1080/09553002.2019.1552373DOI Listing
February 2019

G2-lymphocyte chromosomal radiosensitivity in patients with LPS responsive beige-like anchor protein (LRBA) deficiency.

Int J Radiat Biol 2019 Feb 4:1-11. Epub 2019 Feb 4.

b Research Center for Immunodeficiencies, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.

Lipopolysaccharide-responsive, beige-like anchor protein (LRBA) deficiency is an autosomal recessive primary immunodeficiency disease characterized by a CVID-like phenotype, particularly severe autoimmunity and inflammatory bowel disease. This study was undertaken to evaluate radiation sensitivity in 11 LRBA-deficient patients. Therefore, stimulated lymphocytes of the studied subjects were exposed to a low dose γ-radiation (100 cGy) in the G phase of the cell cycle and chromosomal aberrations were scored. Read More

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http://dx.doi.org/10.1080/09553002.2019.1577570DOI Listing
February 2019
1 Read
1.837 Impact Factor

Applying a multiscale systems biology approach to study the effect of chronic low-dose exposure to uranium in rat kidneys.

Int J Radiat Biol 2019 Feb 4:1-38. Epub 2019 Feb 4.

a Institut de Radioprotection et de Sûreté Nucléaire, PSE-SANTE, SESANE, LRTOX , Fontenay-aux-Roses , F-92260 France.

Purpose: To examine the effects of low-dose exposure to uranium with a systems biology approach, a multiscale high-throughput multi-omics analysis was applied with a protocol for chronic exposure to the rat kidney.

Methods: Male and female rats were contaminated for nine months through their drinking water with a nontoxic solution of uranyl nitrate. A multiscale approach enabled clinical monitoring associated with metabolomic and transcriptomic (mRNA and microRNA) analyses. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1577567DOI Listing
February 2019
6 Reads

Quantification of DNA damage in patients undergoing non-contrast & contrast enhanced whole body PET/CT investigations using comet assay and micronucleus assay.

Int J Radiat Biol 2019 Feb 1:1-25. Epub 2019 Feb 1.

b Department of Biotechnology , Maulana Abul Kalam Azad University of Technology , Salt Lake , Kolkata , India.

Objective: To quantify DNA damage in patients undergoing non-contrast and contrast-enhanced F-FDG PET/CT whole body positron emission tomography/computed tomography (WB PET/CT) investigations using comet assay technique & micronucleus assay. To study the effect of other baseline parameters of patients on DNA damage.

Methodology: 84 patients referred for F-FDG PET/CT investigation were included in the study of which 44 patients underwent contrast-enhanced WB PET/CT and 40 patients underwent non-contrast WB PET/CT investigations. Read More

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http://dx.doi.org/10.1080/09553002.2019.1577569DOI Listing
February 2019

Is stereotactic body radiotherapy for ultra-central lung tumor a feasible option? A systemic review and meta-analysis.

Int J Radiat Biol 2019 Jan 24:1-9. Epub 2019 Jan 24.

d Department of Radiation Oncology , Guro Hospital Korea University Medical College , Seoul , Republic of Korea.

Introduction: Ultra-central (UC) tumors, which are generally defined as tumors directly abutting the proximal bronchial tree, are difficult to treat with stereotactic body radiotherapy (SBRT) owing to possible serious complications. This systemic review and meta-analysis analyzed the early experiences and evaluated the efficacy and feasibility of SBRT for UC tumors.

Methods And Materials: The present study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

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http://dx.doi.org/10.1080/09553002.2019.1552375DOI Listing
January 2019

Epidemiological studies of atomic bomb radiation at the Radiation Effects Research Foundation.

Int J Radiat Biol 2019 Jan 24:1-13. Epub 2019 Jan 24.

e Associate Chief of Research, Radiation Effects Research Foundation , Hiroshima , Japan.

Epidemiological studies of people who were exposed to atomic bomb radiation and their children who were conceived after parental exposure to radiation (F) have investigated late health effects of atomic bomb radiation and its transgenerational effects. Those studies were initiated by the Atomic Bomb Casualty Commission (ABCC) in the 1950s. ABCC was reorganized to the Radiation Effects Research Foundation (RERF) in 1975, which continued the work of the ABCC. Read More

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http://dx.doi.org/10.1080/09553002.2019.1569778DOI Listing
January 2019
1 Read

Differential radio-adaptive responses in BALB/c and C57BL/6 mice: pivotal role of calcium and nitric oxide signalling.

Int J Radiat Biol 2019 Jan 24:1-12. Epub 2019 Jan 24.

a Immunology Section, Radiation Biology & Health Sciences Division , Bio-Science Group, Bhabha Atomic Research Centre , Mumbai , India.

Purpose: Our earlier studies demonstrated that transient radio-adaptive responses (RAR) in BALB/c mice were due to MAPK hyperactivation. The objective of this study was to determine the time duration of this low dose induced MAPK activation in BALB/c mice and to find out if similar adaptive responses are observed in C57BL/6 mice.

Materials And Methods: Mice were irradiated with 0. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1571647DOI Listing
January 2019
5 Reads

International coordination of research: EPRI International Dose Effect Alliance.

Authors:
Donald A Cool

Int J Radiat Biol 2019 Jan 24:1-3. Epub 2019 Jan 24.

a Electric Power Research Institute , Charlotte , NC , USA.

Purpose: The key to increasing our understanding of low dose effects of ionizing radiation is cooperation and communication between research organizations around the world. The purpose of this article is to describe the Electric Power Research Institute (EPRI) program for such cooperation.

Materials And Methods: EPRI is an independent, non-profit organization dedicated to research support for the generation, transmission, and utilization of electricity. Read More

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http://dx.doi.org/10.1080/09553002.2019.1569770DOI Listing
January 2019

Ionizing radiation affects miRNA composition in both young and old mice.

Int J Radiat Biol 2019 Jan 24:1-10. Epub 2019 Jan 24.

a Radiobiology and Health, Canadian Nuclear Laboratories , Chalk River , Ontario , Canada.

Purpose: Humans are exposed to both natural (e.g. soil, cosmic rays) and human-made radiation sources (e. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1569771DOI Listing
January 2019
3 Reads

History of radiation genetics: light and darkness.

Authors:
Nori Nakamura

Int J Radiat Biol 2019 Jan 24:1-31. Epub 2019 Jan 24.

a Dept. Molecular Biosciences , RERF , Hiroshima , 732 , Japan.

Purpose: To review the history of radiation effects in germ cells and to attempt to discern future directions.

Materials And Methods: Review of published papers.

Results: Recent mouse studies using micro-array-based comparative genomic hybridization techniques revealed that germline mutations would occur much less frequently than would be expected from the results of past studies which used specific locus tests. Read More

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http://dx.doi.org/10.1080/09553002.2019.1572251DOI Listing
January 2019

Radiation databases and archives - examples and comparisons.

Int J Radiat Biol 2019 Jan 24:1-12. Epub 2019 Jan 24.

a Feinberg School of Medicine, Radiation Oncology , Northwestern University , Chicago , IL , USA.

Studies of ionizing radiation effects through the archiving of data began with standardizing medical treatments in the early 1900s shortly after the discovery of X-rays. Once the breadth of the delayed effects of ionizing radiation was recognized, the need for long-term follow up became apparent. There are now many human archives of data from nuclear disasters and accidents, occupational exposures, and medical procedures. Read More

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http://dx.doi.org/10.1080/09553002.2019.1572249DOI Listing
January 2019

Infrared spectroscopic demonstration of magnetic orientation in SH-SY5Y neuronal-like cells induced by static or 50 Hz magnetic fields.

Int J Radiat Biol 2019 Jan 22:1-7. Epub 2019 Jan 22.

a Department of Mathematical and Informatics Sciences , Physical Sciences and Earth Sciences, University of Messina , Messina , Italy.

Purpose: To study the response of neuronal-like cells to an applied static or low-frequency magnetic field.

Materials And Methods: Fourier Transform Infrared (FTIR) Spectroscopy was used to investigate the overall behavior of SH-SY5Y neuronal-like cells exposed to a static or 50 Hz magnetic fields at intensities up to 1 mT generated by two Helmholtz coils driven by direct current or alternate current voltage. The Helmholtz coils were placed into an incubator in a 5% CO/95% air humidified at 37 °C. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1571256DOI Listing
January 2019
2 Reads

Chronic low dose exposure of hospital workers to ionizing radiation leads to increased micronuclei frequency and reduced antioxidants in their peripheral blood lymphocytes.

Int J Radiat Biol 2019 Jan 22:1-15. Epub 2019 Jan 22.

c Department of Biotechnology , Mizoram University , Aizawl , India.

Purpose: The regular low dose occupational exposure to ionizing radiation may induce deleterious health effects, which may be of particular interest to medical radiation workers who daily handle X-ray machines. Human peripheral blood lymphocytes are able to retain the signature of radiation-induced DNA damage, therefore, the present study was undertaken to investigate the DNA damage and antioxidants status in hospital workers occupationally exposed to low doses of X-rays.

Materials And Methods: The peripheral blood lymphocytes of the occupationally exposed and control groups matched for age, gender, tobacco usage, and alcohol consumption were cultured and micronuclei frequency was determined. Read More

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http://dx.doi.org/10.1080/09553002.2019.1571255DOI Listing
January 2019

Neutrons are forever! Historical perspectives.

Int J Radiat Biol 2019 Jan 22:1-28. Epub 2019 Jan 22.

a MRC Harwell Institute , Didcot , UK.

Purpose: Neutrons were an active field of radiobiology at the time of publication of the first issues of the International Journal of Radiation Biology in 1959. Three back-to-back papers published by Neary and his colleagues contain key elements of interest at the time. The present article aims to put these papers into context with the discovery of the neutron 27 years previously and then give a feel for how the field has progressed to the present day. Read More

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http://dx.doi.org/10.1080/09553002.2019.1569782DOI Listing
January 2019
2 Reads

Chemical radiosensitizers: the Journal history.

Authors:
John E Moulder

Int J Radiat Biol 2019 Jan 18:1-5. Epub 2019 Jan 18.

a Radiation Oncology , Medical College of Wisconsin , Milwaukee , WI , USA.

Purpose: To review the Journal's coverage of chemical radiosensitizers.

Methods: I have reviewed all the possibly-relevant papers that appeared in the Journal prior to 1970 and since 2010, plus the most highly-cited papers from the intervening years. I excluded papers that dealt only with oxygen as a sensitizer, that referred to sensitization of phototoxicity or hyperthermia, or that described interactions with antineoplastic agents unless they clearly distinguish between additive toxicity and radiosensitization. Read More

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http://dx.doi.org/10.1080/09553002.2019.1569779DOI Listing
January 2019
1 Read

Updated mortality analysis of the Mallinckrodt uranium processing workers, 1942-2012.

Int J Radiat Biol 2019 Jan 17:1-21. Epub 2019 Jan 17.

g National Council on Radiation Protection and Measurements , Bethesda , MD , USA.

Purpose: Mallinckrodt Chemical Works (MCW) was the earliest uranium processing facility in the United States, and in 1942 produced the uranium oxide used for the first sustained and controlled nuclear fission chain-reaction at the University of Chicago. A second follow-up through 2012 was conducted of 2514 White male workers employed 1942-1966 at the MCW for dose-response analyses for selected causes of death.

Materials And Methods: Organ/tissue-specific dose reconstruction included both external (12,686 MCW film badge records, 210 other facility film badge records, and 31,297 occupational chest x-rays) and internal sources of uranium and radium (39,451 urine bioassays, 2341 breath radon measurements, and 6846 ambient radon measurements). Read More

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http://dx.doi.org/10.1080/09553002.2019.1569773DOI Listing
January 2019
3 Reads

Looking for solutions: vision and a call-for-attention for radiation research scientists.

Authors:
Madan M Rehani

Int J Radiat Biol 2019 Jan 17:1-4. Epub 2019 Jan 17.

a Massacusetts General Hospital , Boston , MA , USA.

Purpose: The concept of benefit-risk assessment has often been propagated for clinical professionals for deciding the radiological exam for the patient. A detailed look into how to use this concept leads to several unanswered questions. The purpose of this article is to bring forth questions which have remained unanswered for several decades. Read More

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http://dx.doi.org/10.1080/09553002.2019.1569775DOI Listing
January 2019

Haematopoietic stem and progenitor cell responses to low radiation doses - implications for leukaemia risk.

Int J Radiat Biol 2019 Jan 17:1-26. Epub 2019 Jan 17.

b Public Health England, Centre for Radiation, Chemical and Environmental Hazards , Harwell Campus, Chilton, Didcot , Oxfordshire , OX11 0RQ , UK.

Studies of the responses of haematopoietic stem and progenitor cells (HSPCs) to low doses of ionising radiation formed an important aspect of the RISK-IR project ( www.risk-ir.eu ) . Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1569777DOI Listing
January 2019
3 Reads

Effect of short exposure to radiofrequency electromagnetic fields on saliva biomarkers: a study on the electrohypersensitive individuals.

Int J Radiat Biol 2019 Feb 5:1-5. Epub 2019 Feb 5.

a Department of Experimental Toxicology , Institut National de l'Environnement Industriel et des Risques, (INERIS) , Verneuil-en-Halatte , France.

Context: Some individuals are reporting being sensitive to electromagnetic fields. They report some unspecific symptoms like headeache, sleep disruption, heart palpitations, itching, etc. The lack of scientific objective links between EHS symptoms and EMF exposure renders the diagnosis of EHS more complex. Read More

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http://dx.doi.org/10.1080/09553002.2019.1569776DOI Listing
February 2019

Enhancement of biological effectiveness of carbon-ion beams by applying a longitudinal magnetic field.

Int J Radiat Biol 2019 Jan 17:1-6. Epub 2019 Jan 17.

d National Institute of Radiological Sciences , Chiba , Japan.

Purpose: A magnetic field longitudinal to an ion beam will potentially affect the biological effectiveness of the radiation. The purpose of this study is to experimentally verify the significance of such effects.

Methods And Materials: Human cancer and normal cell lines were exposed to low (12 keV/μm) and high (50 keV/μm) linear energy transfer (LET) carbon-ion beams under the longitudinal magnetic fields of B = 0, 0. Read More

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http://dx.doi.org/10.1080/09553002.2019.1569774DOI Listing
January 2019

Early authors - R. H. Mole.

Int J Radiat Biol 2019 Jan 16:1-4. Epub 2019 Jan 16.

a Department of Biology , McMaster University , Ontario , Hamilton , Canada.

Purpose: To reflect on the contributions of R. H. Mole to radiobiology. Read More

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http://dx.doi.org/10.1080/09553002.2019.1569780DOI Listing
January 2019

Verification of a dose rate-responsive dynamic equilibrium model on radiation-induced mutation frequencies in mice.

Int J Radiat Biol 2019 Jan 16:1-19. Epub 2019 Jan 16.

g Yukawa Institute for Theoretical Physics, Kyoto University , Kyoto , Japan.

Purpose: We have proposed a mathematical model (WAM model) expressing increment of the dose-rate dependent mutation frequency caused by artificial radiations. In this model, it is defined that the pool of mutant cells in dynamic equilibrium in organisms. We verified the accuracy of the WAM prediction of mutation frequency in mice. Read More

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http://dx.doi.org/10.1080/09553002.2019.1569772DOI Listing
January 2019
3 Reads

Assessment of lead tolerance in gamma exposed Aspergillus niger van Tieghem & Penicillium cyclopium Westling.

Int J Radiat Biol 2019 Jan 16:1-10. Epub 2019 Jan 16.

c Department of Environmental Science , University of Kalyani , Kalyani , India.

Purpose: Present study deals with the role of gamma irradiation in modulating lead (Pb) tolerance of Aspergillus niger van Tieghem. and Penicillium cyclopium Westling.

Materials And Methods: After being exposed to gamma absorbed doses those fungal strains were subjected to heavy metal uptake efficacies and anti-oxidative study. Read More

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http://dx.doi.org/10.1080/09553002.2019.1569769DOI Listing
January 2019

A protein-mRNA feedback exists in miR-21-associated E-selectin expression.

Int J Radiat Biol 2019 Jan 11:1-5. Epub 2019 Jan 11.

a Department of Radiation Oncology , Emory University School of Medicine, Winship Cancer Institute of Emory University , Atlanta , GA , USA.

Purpose: To study whether miR-21, an oncogene associated with lung tumorigenesis, affects immune response.

Material And Methods: Cancer immune-related 786 mRNA expression was compared in lung tissue from wild-type and miR-21 knock-in mice using NanoString technology. The significantly changed genes were verified using real-time PCR. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1564082DOI Listing
January 2019
6 Reads

Dose response of prematurely condensed chromosome rings after gamma irradiation.

Int J Radiat Biol 2019 Jan 7:1-4. Epub 2019 Jan 7.

b Centro de Protección e Higiene de las Radiaciones (CPHR) , La Habana , Cuba.

Purpose: This paper presents a calibration curve for prematurely condensed chromosome rings (PCC-ring) which are scarce in cytogenetic dosimetry; here we analyzed the behavior of the PCC-ring frequency and PCC index after gamma irradiation in the dose interval from 0 to 20 Gy.

Materials And Methods: PCC-rings were induced in lymphocytes with Calyculin A. A total of 5788 PCC cells in G1, G2/M, and M/A stages were analyzed. Read More

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http://dx.doi.org/10.1080/09553002.2019.1566677DOI Listing
January 2019

Sex-specific lung cancer risk among radiation workers in the million-person study and patients TB-Fluoroscopy.

Int J Radiat Biol 2019 Jan 7:1-12. Epub 2019 Jan 7.

f EpidStat Institute , Ann Arbor , MI , USA.

Background: The study of Japanese atomic bomb survivors, exposed briefly to radiation, finds the risk of radiation-induced lung cancer to be nearly three times greater for women than for men. Because protection standards for astronauts are based on individual lifetime risk projections, this sex-specific difference limits the time women can spend in space. Populations exposed to chronic or fractionated radiation were evaluated to learn whether similar differences exist when exposures occur gradually over years. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2018.1
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http://dx.doi.org/10.1080/09553002.2018.1547441DOI Listing
January 2019
8 Reads

Assessing the impact of low level laser therapy (LLLT) on biological systems: a review.

Int J Radiat Biol 2019 Jan 7:1-24. Epub 2019 Jan 7.

b School of Biological and Marine Sciences , University of Plymouth , Plymouth , UK.

Purpose: Low level laser therapy (LLLT) in the visible to near infrared spectral band (390-1100 nm) is absorption of laser light at the electronic level, without generation of heat. It may be applied in a wide range of treatments including wound healing, inflammation and pain reduction. Despite its potential beneficial impacts, the use of lasers for therapeutic purposes still remains controversial in mainstream medicine. Read More

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http://dx.doi.org/10.1080/09553002.2019.1524944DOI Listing
January 2019
1 Read

A historical reflection on our understanding of radiation-induced DNA double strand break repair in somatic mammalian cells; interfacing the past with the present.

Int J Radiat Biol 2019 Jan 4:1-36. Epub 2019 Jan 4.

b Genome Damage and Stability Centre, School of Life Sciences, University of Sussex , Brighton , BN19RQ , UK.

Purpose: The International Journal of Radiation Biology (IJRB) is celebrating 60 years of publishing in 2019. IJRB has made an enormous contribution to publishing papers that have enhanced our understanding of the DNA damage response (DDR) activated following exposure to ionising radiation (IR). The IR-induced DDR field has a rich history but many outstanding papers pass unread by young scientists overwhelmed by the current literature. Read More

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http://dx.doi.org/10.1080/09553002.2018.1564083DOI Listing
January 2019

Development of a biodosimeter for radiation triage using novel blood protein biomarker panels in humans and non-human primates.

Int J Radiat Biol 2019 Jan 3:1-13. Epub 2019 Jan 3.

a SRI International , Menlo Park , CA , USA.

Purpose: In a significant nuclear event, hundreds of thousands of individuals will require rapid triage for absorbed radiation to ensure effective medical treatment and efficient use of medical resources. We are developing a rapid screening method to assess whether an individual received an absorbed dose of ≥2 Gy based on the analysis of a specific panel of blood proteins in a fingerstick blood sample.

Materials And Methods: We studied a data set of 1051 human blood samples obtained from radiotherapy patients, normal healthy individuals, and several special population groups. Read More

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http://dx.doi.org/10.1080/09553002.2018.1532611DOI Listing
January 2019
1 Read

Translational Boron Neutron Capture Therapy (BNCT) studies for the treatment of tumors in lung.

Int J Radiat Biol 2019 Jan 2:1-25. Epub 2019 Jan 2.

a Comisión Nacional de Energía Atómica , Argentina.

Purpose: Boron neutron capture therapy (BNCT) combines selective accumulation of B carriers in tumor tissue with subsequent neutron irradiation. BNCT has been proposed for the treatment of multiple, non resectable, diffuse tumors in lung. The aim of the present study was to evaluate the therapeutic efficacy and toxicity of BNCT in an experimental model of lung metastases of colon carcinoma in BDIX rats and perform complementary survival studies. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1564080DOI Listing
January 2019
1 Read

Region-specific reduction of parvalbumin neurons and behavioral changes in adult mice following single exposure to cranial irradiation.

Int J Radiat Biol 2019 Jan 2:1-17. Epub 2019 Jan 2.

c Department of Psychiatry , Kawasaki Medical School , Kurashiki , Japan.

Purpose: Ionizing irradiation has several long-term effects including progressive cognitive impairment. Cognitive deterioration generally appears to be caused by abnormalities in the hippocampal dentate gyrus, with abnormal function of parvalbumin-expressing interneurons (PV neurons) in the cerebral cortex. PV neurons are vulnerable to oxidative stress, which can be caused by ionizing irradiation. Read More

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http://dx.doi.org/10.1080/09553002.2019.1564081DOI Listing
January 2019

Funding for radiation research: past, present and future.

Int J Radiat Biol 2019 Jan 2:1-25. Epub 2019 Jan 2.

k Radiation Safety Research Center , Nuclear Technology Research Laboratory , Central Research Institute of Electric Power Industry (CRIEPI) , Tokyo , Japan.

For more than a century, ionizing radiation has been indispensable mainly in medicine and industry. Radiation research is a multidisciplinary field that investigates radiation effects. Radiation research was very active in the mid- to late 20th century, but has then faced challenges, during which time funding has fluctuated widely. Read More

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http://dx.doi.org/10.1080/09553002.2018.1558303DOI Listing
January 2019
2 Reads

Low-dose radiobiology program at Canadian nuclear laboratories: past, present, and future.

Int J Radiat Biol 2018 Dec 24:1-11. Epub 2018 Dec 24.

a Radiobiology and Health , Canadian Nuclear Laboratories , Chalk River , Canada.

Health risks associated with the exposure of humans to low-dose ionizing radiation are currently estimated using the Linear-No-Threshold model. Over the last few decades, however, this model has been widely criticized for inconsistency with a large body of experimental evidence. Substantial efforts have been made to delineate biological mechanisms and health-related outcomes of low-dose radiation. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2018.1
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http://dx.doi.org/10.1080/09553002.2018.1562252DOI Listing
December 2018
2 Reads

WAG/RijCmcr rat models for injuries to multiple organs by single high dose ionizing radiation: similarities to non-human primates (NHP).

Int J Radiat Biol 2018 Dec 21:1-42. Epub 2018 Dec 21.

a Departments of Radiation Oncology , Medical College of Wisconsin (MCW) , Milwaukee , USA.

Purpose: Defined animal models are needed to pursue the FDA Animal Rule for approval of medical countermeasure for radiation injuries. This study compares WAG/RijCmcr rat and non-human primate (NHP) models for acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE).

Materials And Methods: Irradiation models include total body irradiation, partial body irradiation with bone marrow sparing and whole thorax lung irradiations. Read More

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http://dx.doi.org/10.1080/09553002.2018.1554921DOI Listing
December 2018
1 Read
1.837 Impact Factor

Therapy for prevention and treatment of skin ionizing radiation damage: A review.

Int J Radiat Biol 2018 Dec 20:1-63. Epub 2018 Dec 20.

a Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy , University of Granada , 18071 Granada , Spain.

Purpose: Radiologic accidents or terrorist acts involving radioactive material, as well as radiation exposure in medical or industrial procedures are potential sources of risk for human health. All these risks share a common element, exposure to ionizing radiation. The extent of ionizing radiation injury will depend on a number of independent variables such as dose, type of radiation and tissue, etc. Read More

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http://dx.doi.org/10.1080/09553002.2019.1562254DOI Listing
December 2018

Impairment of Lymphatic Endothelial Barrier Function by X-ray Irradiation.

Int J Radiat Biol 2018 Dec 20:1-25. Epub 2018 Dec 20.

a Department of Medical Physiology , Texas A&M University College of Medicine , Temple , TX , USA.

Purpose: Although the microvascular system is a significant target for radiation-induced effects, the lymphatic response to radiation has not been extensively investigated. This is one of the first investigations characterizing the lymphatic endothelial response to ionizing radiation.

Materials And Methods: Rat mesenteric lymphatic endothelial cells (RMLECs) were exposed to X-ray doses of 0, 0. Read More

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http://dx.doi.org/10.1080/09553002.2019.1562253DOI Listing
December 2018
1 Read

Differential expression of flowering genes in Arabidopsis thaliana under chronic and acute ionizing radiation.

Int J Radiat Biol 2018 Dec 20:1-23. Epub 2018 Dec 20.

a Institute of Cell Biology and Genetic Engineering, National Academy of Sciences of Ukraine , Kiev , Ukraine.

Purpose: Chronic and acute irradiations have drastic effects on flowering stage that plays an important role in the further seed development and can determine seed yield. The expression of the key flowering genes, AP1, CO, GI, FT, FLC, and LFY, sensitive to irradiation repair gene RAD51 and the proliferation gene PCNA2 were studied in the wild type Arabidopsis thaliana (Columbia ecotype) under chronic and acute irradiations.

Materials And Methods: Chronic irradiation was performed using the radioactive isotope СsCl in two total doses of 3 cGy and 17 cGy, with the dose rate of 10 cGy/sec and 6. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1562251DOI Listing
December 2018
9 Reads

MPS dose reconstruction for internal emitters: some site-specific issues and approaches.

Int J Radiat Biol 2018 Dec 18:1-13. Epub 2018 Dec 18.

a Oak Ridge National Laboratory , Oak Ridge , TN , USA.

Background: As part of the Million Person Study (MPS), dose reconstructions for internal emitters have been performed for several U.S. facilities where large quantities of radionuclides were handled. Read More

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http://dx.doi.org/10.1080/09553002.2018.1558302DOI Listing
December 2018

NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity.

Int J Radiat Biol 2018 Dec 18:1-21. Epub 2018 Dec 18.

a Department of Environmental and Occupational Health , College of Public Health, University of Arkansas for Medical Sciences , Little Rock , United States of America.

Purpose: Growing rates of metabolic syndrome and associated obesity warrant the development of appropriate animal models for better understanding of how those conditions may affect sensitivity to IR exposure.

Materials And Methods: We subjected male NZO/HlLtJ mice, a strain prone to spontaneous obesity and diabetes, to 0, 5.5, 6. Read More

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http://dx.doi.org/10.1080/09553002.2018.1547437DOI Listing
December 2018

Effect of a change in reactor power on response of murine solid tumors in vivo, referring to impact on quiescent tumor cell population.

Int J Radiat Biol 2018 Dec 17:1-28. Epub 2018 Dec 17.

c Particle Radiation Oncology Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010, Asashiro-nishi, Kumatori-cho, Sennan-gun , Osaka , 590-0494 , Japan.

Purpose: To examine the effect of a change in reactor power on the response of solid tumors, referring to impact on quiescent (Q) tumor cell population.

Materials And Methods: Tumor-bearing mice received 5-bromo-2-deoxyuridine (BrdU) to label all proliferating (P) tumor cells, and were treated with boronophenylalanine-B (BPA) or sodium mercaptododecaborate-B (BSH). After reactor neutron beam irradiation at a power of 1 or 5 MW with an identical beam spectrum, cells from tumors were isolated and incubated with a cytokinesis blocker. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1558300DOI Listing
December 2018
3 Reads

Glutaminase Inhibitor CB-839 Increases Radiation Sensitivity of Lung Tumor Cells and Human Lung Tumor Xenografts in Mice.

Int J Radiat Biol 2018 Dec 17:1-23. Epub 2018 Dec 17.

b The Winthrop P. Rockefeller Cancer Institute.

Purpose: The purpose of this study was to translate our in vitro therapy approach to an in vivo model. Increased glutamine uptake is known to drive cancer cell proliferation, making tumor cells glutamine-dependent. Studying lymph-node aspirates containing malignant lung tumor cells showed a strong correlation between glutamine consumption and glutathione (GSH) excretion. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2018.1
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http://dx.doi.org/10.1080/09553002.2018.1558299DOI Listing
December 2018
7 Reads

Biological characteristics of gene expression features in pancreatic cancer cells induced by proton and X-ray irradiation.

Int J Radiat Biol 2018 Dec 17:1-44. Epub 2018 Dec 17.

a Disease control and homeostasis , Kanazawa University , 13-1 Takara-machi , Kanazawa , 920-8641 , Japan .

Background: Radiation therapy is an important alternative treatment for advanced cancer. The aim of the current study was to disclose distinct alterations of the biological characteristics of gene expression features in pancreatic cancer cells, MIAPaCa-2, following proton and X-ray irradiation.

Materials And Methods: Using cDNA microarray, we examined the gene expression alterations of MIAPaCa-2 cells following proton or X-ray irradiation. Read More

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http://dx.doi.org/10.1080/09553002.2019.1558297DOI Listing
December 2018

Evaluation of mature miR398 family, expression analysis and the post transcriptional regulation evidence in gamma-irradiated and nitrogen stressed Medicago sativa seedlings.

Int J Radiat Biol 2018 Dec 17:1-36. Epub 2018 Dec 17.

a Department of Biotechnology, School of Life Sciences , Pondicherry University , Kalapet , Puducherry - 605014 , India.

Background: The miRNA398 (microRNA398) post transcriptionally regulates the superoxide dismutase (Cu/Zn-SOD).

Materials And Methods: The miRNA398 level were quantitated in gamma irradiated 20Gy and 200Gy and nitrogen stressed seedlings by stem-loop RT-PCR (Real Time- Polymerase chain reaction). The positional preference of nucleotide for miR398 families and new targets was done. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1558298DOI Listing
December 2018
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Reversibility of castration resistance status after Radium-223 dichloride treatment: Clinical evidence and Review of the literature.

Int J Radiat Biol 2018 Dec 17:1-29. Epub 2018 Dec 17.

a Department of Radiological Sciences, Oncology and Anatomical Pathology , Sapienza University of Rome , Viale Regina Elena 324 , 00161 , Rome , Italy.

Purpose: In the history of prostate cancer, some of patients progresses to castration resistant prostate cancer (CRPC) stage and, although new drugs and treatment protocols have been introduced, CRPC presents poor prognosis. This review focused on biological mechanisms, underlying CRPC described in scientific literature in order to explain the reversion of resistance to castration. We present the case of a 73 years-old man, affected by bone metastatic CRPC, early treated with Radium-223 with a complete response. Read More

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http://dx.doi.org/10.1080/09553002.2019.1558301DOI Listing
December 2018

Therapeutic potential of natural plant products and their metabolites in preventing radiation enteropathy resulting from abdominal or pelvic irradiation.

Int J Radiat Biol 2018 Dec 7:1-43. Epub 2018 Dec 7.

a Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy.

Purpose: Radiation-induced gastrointestinal injury or radiation enteropathy is an imminent risk during radiation therapy of abdominal or pelvic tumors. Despite remarkable technological advancements in image-guided radiation delivery techniques, the risk of intestinal injury after radiotherapy for abdominal or pelvic cancers has not been completely eliminated. The irradiated intestine undergoes varying degrees of adverse structural and functional changes, which can result in transient or long-term complications. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2018.1
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http://dx.doi.org/10.1080/09553002.2018.1552374DOI Listing
December 2018
3 Reads

Effect of low-dose X-rays on the liver of whole-body irradiated rats.

Int J Radiat Biol 2018 Dec 3:1-27. Epub 2018 Dec 3.

c Physics Department, Faculty of Science , Mansoura University , Mansoura , Egypt .

Purpose: To investigate the effect of whole body low-dose radiation (10 cGy of 6 MeV x-rays) given prior to a challenging dose of 2 Gy x-rays on adaptive response in the liver of rats Materials and Methods: Rats were either irradiated with 10cGy, 2Gy or 10cGy 24h prior to 2Gy (10cGy-2Gy irradiated). Liver samples were analysed for apoptosis,caspase-3, Bcl-2, by flow cytometery. DNA damage was determined by alkaline comet assay. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1554925DOI Listing
December 2018
14 Reads

Effects of CKMT1 on radiosensitivity of nasopharyngeal carcinoma cells.

Int J Radiat Biol 2018 Dec 3:1-25. Epub 2018 Dec 3.

a Central Lab, First Affiliated Hospital of Fujian Medical University , Fuzhou , Fujian 350005 , China.

Purpose: Radioresistance is an important factor for unsatisfactory prognosis in Nasopharyngeal carcinoma (NPC) patients. Ubiquitous mitochondrial creatine kinase (CKMT1) is always associated with malignancy in a variety of cancers. However, its significance in NPC progression and radiosensitivity remains unclear. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
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http://dx.doi.org/10.1080/09553002.2019.1554919DOI Listing
December 2018
7 Reads

Role of a high throughput biodosimetry test in treatment prioritization after a nuclear incident.

Int J Radiat Biol 2018 Dec 3:1-9. Epub 2018 Dec 3.

a DxTerity Diagnostics , Los Angeles , CA , USA.

Purpose: We introduce and evaluate a high throughput biodosimetry test system (REDI-Dx) suitable for testing of thousands of potential radiation victims following a mass scale nuclear event caused by detonation of a nuclear device or a nuclear accident, as part of an overall strategy for effective medical management of the crisis.

Materials And Methods: The performance of a high throughput biodosimetry test was evaluated by collecting samples of both non-irradiated presumed healthy donors as well as irradiated subjects collected as part of either cancer treatment regimens or banked from previous studies. The test measures the gene expression of a set of radiation responsive genes based on the DxDirect genomic platform. Read More

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http://dx.doi.org/10.1080/09553002.2018.1532615DOI Listing
December 2018