508,404 results match your criteria International Journal of Ozone Therapy[Journal]


MiR-204-5p: a novel candidate urinary biomarker of Xp11.2 translocation renal cell carcinoma.

Cancer Sci 2019 Apr 21. Epub 2019 Apr 21.

Department of Molecular Genetics.

Xp11.2 translocation renal cell carcinoma (Xp11 tRCC) is a rare sporadic pediatric kidney cancer caused by constitutively active TFE3 fusion proteins. Tumors in patients with Xp11 tRCC tend to recur and undergo frequent metastasis, in part due to lack of methods available to detect early stage disease. Read More

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http://dx.doi.org/10.1111/cas.14026DOI Listing
April 2019
1 Read

Intra-articular triamcinolone acetonide improves lung function in horses with severe asthma.

Equine Vet J 2019 Apr 21. Epub 2019 Apr 21.

Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, 3200 rue Sicotte, Saint-Hyacinthe, J2S 2M2, Quebec, Canada.

Background: Locally administered corticosteroids are commonly used to treat joint diseases in sport and racehorses. As they are also the most potent drugs for the treatment of equine asthma, we hypothesised that the intra-articular corticosteroids used to treat joint diseases also improve the lung function in horses with severe asthma, thus potentially delaying the diagnosis of this common lung condition.

Objectives: To compare the effects of intra-articular (IA) and intramuscular (IM) triamcinolone acetonide (TA) on lung function in horses with severe asthma. Read More

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http://dx.doi.org/10.1111/evj.13128DOI Listing

Increasing carbohydrate availability in the hindgut promotes hypothalamic neurotransmitter synthesis: aromatic amino acids linking the microbiota-brain axis.

J Neurochem 2019 Apr 21. Epub 2019 Apr 21.

Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.

The gut microbiota is increasingly recognized to modulate brain function by recent studies demonstrating the central effects of various gut microbial manipulation strategies. Our previous study demonstrated that antibiotics-induced alterations of hindgut microbiota are associated with changes in aromatic amino acid (AAA) metabolism and hypothalamic neurochemistry, while the underlying mechanism insight is limited. Given that the microbial AAA metabolism can be affected by luminal carbohydrate availability, here we hypothesize that increasing hindgut carbohydrate availability affects the expression of neurotransmitters in the porcine hypothalamus. Read More

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http://dx.doi.org/10.1111/jnc.14709DOI Listing

Pharmacovigilance Systems in Arab Countries: Overview of 22 Arab Countries.

Drug Saf 2019 Apr 20. Epub 2019 Apr 20.

College of Pharmacy, Department of Clinical Pharmacy, University of Hail, P.O. Box 6166, Hail, 81442, Saudi Arabia.

Pharmacovigilance has received much attention in Arab countries recently due to the development of new regulations. However, there are differences in the progression of pharmacovigilance systems by regulatory agencies in these countries because only some are able to meet the requirements for conducting pharmacovigilance activities. Only 45% of Arab countries are official members of the World Health Organization (WHO) Collaborating Centre for International Drug Monitoring. Read More

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http://link.springer.com/10.1007/s40264-019-00807-4
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http://dx.doi.org/10.1007/s40264-019-00807-4DOI Listing
April 2019
3 Reads

Lipopolysaccharide in systemic circulation induces activation of inflammatory response and oxidative stress in cardiorenal syndrome type 1.

J Nephrol 2019 Apr 20. Epub 2019 Apr 20.

Department of Nephrology, Dialysis and Transplantation, St Bortolo Hospital, International Renal Research Institute Vicenza, Via Rodolfi, 37, 36100, Vicenza, Italy.

Background: Cardiorenal syndrome type 1 (CRS type 1) is characterized by a rapid worsening of cardiac function leading to acute kidney injury. In this study, we evaluate the role of lipopolysaccharide (LPS) and various inflammatory markers in the developing acute kidney injury (AKI) in acute heart failure (AHF) patients.

Methods: We enrolled 31 AHF patients and 20 CRS type 1 (the cause of AKI was presumed to be related to cardiac dysfunction) and 17 healthy volunteers without AHF, AKI or CKD, as control group (CTR). Read More

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http://dx.doi.org/10.1007/s40620-019-00613-2DOI Listing

Validity and reliability of the French version of Eating Assessment Tool (EAT-10).

Eur Arch Otorhinolaryngol 2019 Apr 20. Epub 2019 Apr 20.

Department of Otolaryngology-Head & Neck Surgery, CHU Saint-Pierre (CHU de Bruxelles), Université Libre de Bruxelles, Brussels, Belgium.

Objective: To develop a French version of the Eating Assessment Tool (Fr EAT-10) and to assess its internal consistency, reliability and clinical validity.

Methods: Fifty-six patients referred in the Swallowing Clinics of CHU Saint-Pierre Hospital (Brussels) and EpiCURA hospital (Ath, Belgium) for dysphagia were enrolled and completed fiberoptic endoscopic evaluation of swallowing and videofluoroscopy. Seventy-three asymptomatic subjects were included in the study. Read More

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http://dx.doi.org/10.1007/s00405-019-05429-1DOI Listing

On prognostic estimates of radiation risk in medicine and radiation protection.

Radiat Environ Biophys 2019 Apr 20. Epub 2019 Apr 20.

Department of Physics, Science Faculty, University of Zürich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

The problem of expressing cumulative detrimental effect of radiation exposure is revisited. All conventionally used and computationally complex lifetime or time-integrated risks are based on current population and health statistical data, with unknown future secular trends, that are projected far into the future. It is shown that application of conventionally used lifetime or time-integrated attributable risks (LAR, AR) should be limited to exposures under 1 Gy. Read More

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http://link.springer.com/10.1007/s00411-019-00794-1
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http://dx.doi.org/10.1007/s00411-019-00794-1DOI Listing
April 2019
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Clinical correlates of abnormal subcortical volumes in Essential Tremor.

J Neural Transm (Vienna) 2019 Apr 20. Epub 2019 Apr 20.

Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore, Karnataka, 560029, India.

Essential tremor (ET) is considered to be a neurodegenerative disorder and it is plausible that the observed motor and non-motor symptoms may be attributable to functional alterations secondary to abnormalities of subcortical nuclei. This study aims to compare the volumes of subcortical nuclei in patients with ET to ascertain neuroimaging correlates of motor and non-motor features of ET. Forty patients of ET and 40 age- and gender-matched healthy controls (HC) were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s00702-019-02004-0DOI Listing

Advocacy coalitions and the transfer of nutrition policy to Zambia.

Authors:
Jody Harris

Health Policy Plan 2019 Apr 21. Epub 2019 Apr 21.

Institute of Development Studies, Library Road, University of Sussex, BN1 9RE, Brighton, UK.

Stunted growth in children and multisectoral action to address it are dominant ideas in the international nutrition community today, and this study finds that these ideas are increasingly evident over time in nutrition policy in Zambia, with stunting largely displacing other framings of nutrition. This study is based on key informant interviews (70 interviews with 61 interviewees), policy document review, and social network mapping, with iterative data collection and analysis taking place over 6 years (2011-2016). Analysis was based on two established political science theories: policy transfer theory and the Advocacy Coalition Framework. Read More

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https://academic.oup.com/heapol/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/heapol/czz024DOI Listing
April 2019
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Establishment of an international autoantibody reference standard for human anti-DFS70 antibodies: proof-of-concept study for a novel Megapool strategy by pooling individual specific sera.

Clin Chem Lab Med 2019 Apr 22. Epub 2019 Apr 22.

Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu 740 3° andar, 04023-062 São Paulo, Brazil.

Background International autoantibody standards, traditionally based on material obtained from plasmapheresis of single subjects, represent individual immune response and may not comprehend the heterogeneity of the general population. The anti-DFS70 autoantibody yields a characteristic dense fine speckled (DFS) nuclear pattern on indirect immunofluorescence assay on HEp-2 cells (HEp-2 IFA) and speaks against autoimmunity. We propose a novel strategy for developing autoantibody reference standards, based on stepwise pooling of serum samples from hundreds of individuals with anti-DFS70 antibodies. Read More

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
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http://dx.doi.org/10.1515/cclm-2019-0087DOI Listing
April 2019
1 Read

Next-generation reference intervals for pediatric hematology.

Clin Chem Lab Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.

Background Interpreting hematology analytes in children is challenging due to the extensive changes in hematopoiesis that accompany physiological development and lead to pronounced sex- and age-specific dynamics. Continuous percentile charts from birth to adulthood allow accurate consideration of these dynamics. However, the ethical and practical challenges unique to pediatric reference intervals have restricted the creation of such percentile charts, and limitations in current approaches to laboratory test result displays restrict their use when guiding clinical decisions. Read More

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
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http://dx.doi.org/10.1515/cclm-2018-1236DOI Listing
April 2019
1 Read

Could implementation of mifepristone address Canada's urban-rural abortion access disparity: a mixed-methods implementation study protocol.

BMJ Open 2019 Apr 20;9(4):e028443. Epub 2019 Apr 20.

Department of Family & Community Medicine, University of Toronto, Toronto, Ontario, Canada.

Introduction: In January 2017, mifepristone-induced medical abortion was made available in Canada. In this study, we will seek to (1) understand facilitators and barriers to the implementation of mifepristone across Canada, (2) assess the impact of a 'community of practice' clinical and health service support platform and (3) engage in and assess the impact of integrated knowledge translation (iKT) activities aimed to improve health policy, systems and service delivery issues to enhance patient access to mifepristone.

Methods And Analysis: This prospective mixed-methods implementation study will involve a national sample of physicians and pharmacists recruited via an online training programme, professional networks and a purpose-built community of practice website. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028443DOI Listing

Description of the BRIGHTLIGHT cohort: the evaluation of teenage and young adult cancer services in England.

BMJ Open 2019 Apr 20;9(4):e027797. Epub 2019 Apr 20.

Department of Oncology, University College London Hospitals NHS Foundation Trust, London, UK.

Objective: International recognition of the unique needs of young people with cancer is growing. Many countries have developed specialist age-appropriate cancer services believing them to be of value. In England, 13 specialist principal treatment centres (PTCs) deliver cancer care to young people. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027797DOI Listing

Accuracy of mortality statistics in Palestine: a retrospective cohort study.

BMJ Open 2019 Apr 20;9(4):e026640. Epub 2019 Apr 20.

Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.

Objective: To examine the accuracy of mortality statistics in Palestine, to identify gaps and to provide evidence-based recommendations to improve mortality statistics in Palestine.

Study Design And Setting: A retrospective death registry-based study that examined a stratified random sample of death notification forms (DNFs) of patients who died in hospitals in Palestine was reported in 2012. We randomly selected 600 deceased from the Cause of Death Registry: 400 from the West Bank and 200 from the Gaza Strip. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02664
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http://dx.doi.org/10.1136/bmjopen-2018-026640DOI Listing
April 2019
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International prospective observational study on intracranial pressure in intensive care (ICU): the SYNAPSE-ICU study protocol.

BMJ Open 2019 Apr 20;9(4):e026552. Epub 2019 Apr 20.

Department of Public Health, Erasmus MC, Rotterdam, Netherlands.

Introduction: Intracranial pressure (ICP) monitoring is commonly used in neurocritical care patients with acute brain injury (ABI). Practice about indications and use of ICP monitoring in patients with ABI remains, however, highly variable in high-income countries, while data on ICP monitoring in low and middle-income countries are scarce or inconsistent. The aim of the SYNAPSE-ICU study is to describe current practices of ICP monitoring using a worldwide sample and to quantify practice variations in ICP monitoring and management in neurocritical care ABI patients. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026552DOI Listing
April 2019
1 Read

Protocol for the Gut Bugs Trial: a randomised double-blind placebo-controlled trial of gut microbiome transfer for the treatment of obesity in adolescents.

BMJ Open 2019 Apr 20;9(4):e026174. Epub 2019 Apr 20.

Liggins Institute, University of Auckland, Auckland, New Zealand.

Introduction: Animal studies showed that germ-free mice inoculated with normal mouse gut bacteria developed obesity, insulin resistance and higher triglyceride levels, despite similar food intake. In humans, an association has been found between obesity and gut microbiome dysbiosis. However, gut microbiome transfer has not been evaluated for the treatment of human obesity. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02617
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http://dx.doi.org/10.1136/bmjopen-2018-026174DOI Listing
April 2019
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Genetic components of human pain sensitivity: a protocol for a genome-wide association study of experimental pain in healthy volunteers.

BMJ Open 2019 Apr 20;9(4):e025530. Epub 2019 Apr 20.

Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.

Introduction: Pain constitutes a major component of the global burden of diseases. Recent studies suggest a strong genetic contribution to pain susceptibility and severity. Whereas most of the available evidence relies on candidate gene association or linkage studies, research on the genetic basis of pain sensitivity using genome-wide association studies (GWAS) is still in its infancy. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025530DOI Listing

Multidimensional analysis of factors responsible for the low prevalence of ambulatory peritoneal dialysis in Germany (MAU-PD): a cross-sectional Mixed-Methods Study Protocol.

BMJ Open 2019 Apr 20;9(4):e025451. Epub 2019 Apr 20.

Dr Klaus-Ketzler-Zentrum, KfH-Nierenzentrum, Wiesbaden, Germany.

Introduction: Patients with end-stage kidney failure can be treated either by transplant or by dialysis, which can be administered as haemodialysis (HD) or peritoneal dialysis (PD). Although they are equivalent therapeutic options in terms of mortality, the percentage of patients in Germany treated with PD is currently very low (∼6%) compared with other countries. The aim of our study is to analyse the factors behind this percentage and their relevance to the choice of dialysis treatment in Germany. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025451DOI Listing

Effectiveness of an antenatal maternal supplementation with prebiotics for preventing atopic dermatitis in high-risk children (the PREGRALL study): protocol for a randomised controlled trial.

BMJ Open 2019 Apr 20;9(4):e024974. Epub 2019 Apr 20.

Department of Dermatology, Centre Hospitalier Universitaire de Nantes, Nantes, Pays de la Loire, France.

Introduction: Atopic dermatitis (AD) is a chronic inflammatory disease affecting 10%-15% of children in Europe. There is a need for new primary preventive therapeutic strategies in at-risk populations. Recent research has indicated that atopic diseases are associated with a disrupted gut microbial 'balance' in early life raising the possibility that interventions which yield optimal patterns of microflora could improve host's health. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02497
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http://dx.doi.org/10.1136/bmjopen-2018-024974DOI Listing
April 2019
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Positive and negative social support and depressive symptoms according to economic status among adults in Korea: cross-sectional results from the Health Examinees-Gem Study.

BMJ Open 2019 Apr 20;9(4):e023036. Epub 2019 Apr 20.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Objectives: The interaction between positive and negative social support as well as each domain of social support and income on depressive symptom has not been much explored. We aimed to examine the associations of positive and negative social support with the risk of depressive symptoms among urban-dwelling adults in Korea, focusing on those interaction effects.

Design: We used the first wave of a large-scale cohort study called The Health Examinees-Gem Study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023036DOI Listing

Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis.

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Paediatric Rheumatology and Immunology, University of Münster, Münster, Germany

Objectives: The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early, while later a subgroup of patients develops aggressive joint disease. The proposed biphasic model of SJIA also implies a 'window of opportunity' to abrogate the development of chronic arthritis. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21505
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http://dx.doi.org/10.1136/annrheumdis-2019-215051DOI Listing
April 2019
1 Read

Combat medic course: evaluation of trainees' perception of learning and academic-self perception.

J R Army Med Corps 2019 Apr 20. Epub 2019 Apr 20.

Department of Military Health Services, Gülhane Health Science Institute, Saglik Bilimleri Universitesi, Ankara, Turkey

Introduction: In response to the Syrian Civil War, the Turkish Armed Forces has focused its attention on internal security and border operations, thereby cushioning against both the threat of terrorist activities and supporting international peace efforts. This study was performed to evaluate the level of knowledge, skills and any behavioural changes after the combat medic course to enhance future courses.

Methods: A cross-sectional descriptive study was conducted between 25 December 2017 and 22 March 2018 using 40 combatant personnel undertaking the combat medic training course. Read More

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http://dx.doi.org/10.1136/jramc-2018-001027DOI Listing

Medical services policy in respect of detainees: evolution and outstanding issues.

Authors:
Louis Lillywhite

J R Army Med Corps 2019 Apr 20. Epub 2019 Apr 20.

Centre on Global Health Security, The Royal Institute of International Affairs (Chatham House), London, UK

Alleged and confirmed abuse of civilians arrested or detained by the UK Armed Forces has been the subject of four formal enquiries, and all have used medical evidence and/or addressed medical issues. After the first three, robust policies were put in place to ensure that all those arrested had appropriate medical examinations and that healthcare personnel acted appropriately. However, by the time of the Second Gulf War, the training and medical processes had lapsed and were found to be a contributory factor in not preventing abuse. Read More

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http://dx.doi.org/10.1136/jramc-2019-001156DOI Listing

Epoetin alfa for the treatment of myelodysplastic syndrome-related anemia: A review of clinical data, clinical guidelines, and treatment protocols.

Leuk Res 2019 Mar 27;81:35-42. Epub 2019 Mar 27.

Institut Multidisciplinaire d'Oncologie, Clinique de Genolier, Genolier, Switzerland. Electronic address:

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis, leading to hematopoietic precursor cell apoptosis and peripheral blood cytopenias. Anemia is the most frequently experienced cytopenia and is the main cause of MDS symptoms, with fatigue and dyspnea contributing to reduced quality of life and increased morbidity. As MDS disease course and prognosis is influenced by disease factors, prognostic scoring systems have been developed for MDS to aid clinical and therapeutic decisions following diagnosis. Read More

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http://dx.doi.org/10.1016/j.leukres.2019.03.006DOI Listing

An FPSE-HPLC-PDA method for rapid determination of solar UV filters in human whole blood, plasma and urine.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 16;1118-1119:40-50. Epub 2019 Apr 16.

International Forensic Research Institute, Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA. Electronic address:

This paper reports a novel fabric phase sorptive extraction-high performance liquid chromatography-photodiode array detection (FPSE-HPLC-PDA) method for the simultaneous extraction and analysis of six benzophenone derivative UV filters including benzophenone (BZ); 5-benzoyl-4-hydroxy-methoxybenzenesulfonic acid (BP-4); bis(4-hydroxyphenyl)methanone (4-DHB); bis(2,4-dihydroxyphenyl)methanone (BP-2); (2,4-dihydroxybenzophenone) (BP-1) and 2,2'-dihydroxy-4-methoxybenzophenone (DHMB) in human whole blood, plasma and urine samples. Chromatographic separation method was conducted using a Spherisorb ODS 1 (C) column in isocratic elution mode with a run time <25 min. The FPSE-HPLC-PDA method was validated in the range from 0. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.028DOI Listing

Facile one-step fabrication of glucose oxidase loaded polymeric nanoparticles decorating MWCNTs for constructing glucose biosensing platform: Structure matters.

Biosens Bioelectron 2019 Apr 13;135:153-159. Epub 2019 Apr 13.

School of Materials Science and Engineering, Georgia Institute of Technology, 771 Ferst Drive NW, Atlanta, GA, 30332, United States.

A novel and robust enzymatic biosensing platform with high sensitivity is developed based on facile one-step assembled bio-nanocomposites with enzymes-loaded polymeric nanoparticles decorating multi-walled carbon nanotubes (MWCNTs). An amphiphilic copolymer PAVE containing photo-cross-linkable coumarin segments and carboxylic groups was co-assembled with MWCNTs in aqueous solution while encapsulating the model enzyme namely glucose oxidase (GOx) simultaneously, generating necklace-like bio-nanocomposites (GOx@PAVE-CNTs) with GOx-loading polymeric nanoparticles as nanobeads and MWCNTs as conducting micron-string. Then the GOx@PAVE-CNTs bio-nanocomposites were electro-deposited onto electrode surface and a robust biosensing complex film with porous network structure was formed after following photo-cross-linking. Read More

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http://dx.doi.org/10.1016/j.bios.2019.04.017DOI Listing

A novel telecoupling framework to assess social relations across spatial scales for ecosystem services research.

J Environ Manage 2019 Apr 18;241:251-263. Epub 2019 Apr 18.

Agricultural Research for Development (CIRAD), University of Montpellier, Montpellier, France; Centre for International Forestry Research (CIFOR), Lima, Peru.

Access to ecosystem services and influence on their management are structured by social relations among actors, which often occur across spatial scales. Such cross-scale social relations can be analysed through a telecoupling framework as decisions taken at local scales are often shaped by actors at larger scales. Analyzing these cross-scale relations is critical to create effective and equitable strategies to manage ecosystem services. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.04.029DOI Listing

Treatment of murine lupus with TIGIT-Ig.

Clin Immunol 2019 Apr 18. Epub 2019 Apr 18.

Department of Biophysics, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China; Team SMMU-China of International Genetically Engineered Machine (iGEM) competitions, Department of Biophysics, Second Military Medical University, Shanghai 200433, China. Electronic address:

The TIGIT (T cell immunoreceptor with Ig and ITIM domains) protein is a co-inhibitory receptor that has been reported to suppress autoreactive T and B cells to trigger immunological tolerance. We generated a new recombinant protein by connecting the extracellular domain of murine TIGIT to the Fc region of the rat immunoglobulin IgG2a. The fusion protein was then characterized. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.007DOI Listing

Nicotine Inhibits Rapamycin-induced Pain through Activating mTORC1/S6K/IRS-1-related Feedback Inhibition Loop.

Brain Res Bull 2019 Apr 18. Epub 2019 Apr 18.

State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Pharmacy, School of Stomatology, Fourth Military Medical University, Xi'an, China. Electronic address:

Mammalian target of rapamycin complex 1 (mTORC1) inhibitors increase the incidence of pain in patients, and this finding has been replicated in animal models. However, reports on possible analgesics for this condition are scant. Accumulating evidence finds that nicotinic acetylcholine receptors (nAChRs) are involved in mediating pain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230193020
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http://dx.doi.org/10.1016/j.brainresbull.2019.04.016DOI Listing
April 2019
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Managing and Preventing Vascular Catheter Infections ISID Position Paper.

Int J Infect Dis 2019 Apr 18. Epub 2019 Apr 18.

VCU Medical Center, Richmond, VA, USA.

A panel of experts was convened by the International Society for Infectious Diseases (ISID) to overview recommendations on managing and preventing vascular catheter infections, specifically for the prevention and management of central line-associated bloodstream infections. These recommendations are intended to provide insight for healthcare professionals regarding the prevention of infection in the placement and maintenance of the catheter and diagnosis as well as treatment of catheter infection. Aspects of this area in pediatrics and in limited-resource situations and a discussion regarding the selection of empiric or targeted antimicrobial therapy are particular strengths of this position paper. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193018
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http://dx.doi.org/10.1016/j.ijid.2019.04.014DOI Listing
April 2019
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Prediction of Antioxidant proteins by incorporating statistical moments based features into Chou's PseAAC.

J Theor Biol 2019 Apr 18. Epub 2019 Apr 18.

Department of Computer Science, School of Systems and Technology, University of Management and Technology, Lahore, Pakistan.

Antioxidant proteins are considered crucial in the areas of research on life sciences and pharmacology. They prevent damage to cells and DNA which are caused by free radicals. The role of antioxidants in the ageing process makes them more significant in their accurate identification. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.04.019DOI Listing

Taking the Edge out of High-Risk Selfies in Adventure Tourists.

Wilderness Environ Med 2019 Apr 17. Epub 2019 Apr 17.

School of Medicine, National University of Ireland Galway, Galway, Ireland.

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http://dx.doi.org/10.1016/j.wem.2019.02.001DOI Listing

Thermal insulation design bioinspired by microstructure study of penguin feather and polar bear hair.

Acta Biomater 2019 Apr 18. Epub 2019 Apr 18.

International Centre of Electron Microscopy for Materials Science, Faculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, Poland; AGH University of Science and Technology, Al. A. Mickiewicza 30, 30-059 Kraków, Poland. Electronic address:

Nature is an amazing source of inspiration for the design of thermal insulation strategies, which are key for saving energy. In nature, thermal insulation structures, such as penguin feather and polar bear hair, are well developed; enabling the animals' survival in frigid waters. The detailed microscopy investigations conducted in this study, allowed us to perform microstructural analysis of these thermally insulating materials, including statistical measurements of keratin fiber and pore dimensions directly from high resolution Scanning Electron Microscope (SEM) images. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.031DOI Listing

The International Liver Congress 2019.

Authors:
Rob Brierley

Lancet Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

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http://dx.doi.org/10.1016/S2468-1253(19)30122-0DOI Listing

1-Year Impact on Medical Practice and Clinical Outcomes of FFR: The ADVANCE Registry.

JACC Cardiovasc Imaging 2019 Mar 17. Epub 2019 Mar 17.

Department of Radiology, Providence Health Care, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.

Objectives: The 1-year data from the international ADVANCE (Assessing Diagnostic Value of Non-invasive FFR in Coronary Care) Registry of patients undergoing coronary computed tomography angiography (CTA) was used to evaluate the relationship of fractional flow reserve derived from coronary CTA (FFR) with downstream care and clinical outcomes.

Background: Guidelines for management of chest pain using noninvasive imaging pathways are based on short- to intermediate-term outcomes.

Methods: Patients (N = 5,083) evaluated for clinically suspected coronary artery disease and in whom atherosclerosis was identified by coronary CTA were prospectively enrolled at 38 international sites from July 15, 2015, to October 20, 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1936878X193022
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http://dx.doi.org/10.1016/j.jcmg.2019.03.003DOI Listing
March 2019
1 Read

Lightweight Lead Aprons: The Emperor's New Clothes in the Angiography Suite?

Eur J Vasc Endovasc Surg 2019 Apr 18. Epub 2019 Apr 18.

Department of Vascular and Endovascular Surgery, Royal Adelaide Hospital, Port Road, Adelaide, SA 5000, Australia; The University of Adelaide, SA, Australia.

Objective: The aim was to determine whether lead containing and lead free composite garments in current use provide the level of radiation protection stated by manufacturers.

Methods: Fifteen garments, produced by five different manufacturers using eight different composites, were randomly selected for testing from four hospitals in South Australia. Labelling, material composition, design, and condition of the garments were assessed by direct garment examination, garment label, and product information. Read More

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http://dx.doi.org/10.1016/j.ejvs.2019.01.031DOI Listing

[Positioning for the management of arterial hypertension in Primary Care from the critical analysis of the American (2017) and European (2018) guidelines. Spanish Society of Primary Care Physicians (SEMERGEN)].

Semergen 2019 Apr 18. Epub 2019 Apr 18.

Servicio de Cardiología, Hospital Universitario La Paz, Madrid, España.

The Scientific Societies of Primary Care, being the area in which there is a considerable prevalence of Arterial Hypertension (AHT), need to periodically evaluate the international guidelines for its management. This is particularly relevant when disparate guidelines make it difficult to make decisions in daily clinical practice. The present document has as its aim to analyse the changes and new developments proposed in the guidelines of the American College of Cardiology and the American Heart Association (ACC/AHA 2017), as well as in the guidelines of the European Society of Cardiology and European Society of Hypertension (ESC/ESH 2018). Read More

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http://dx.doi.org/10.1016/j.semerg.2019.02.003DOI Listing

Is hepatectomy safe following Yttrium-90 therapy? A multi-institutional international experience.

HPB (Oxford) 2019 Apr 17. Epub 2019 Apr 17.

University of Wisconsin, United States.

Background: Single institution reports demonstrate variable safety profiles when liver-directed therapy with Yttrium-90 (Y-90) is followed by hepatectomy. We hypothesized that in well-selected patients, hepatectomy after Y90 is feasible and safe.

Methods: Nine institutions contributed data for patients undergoing Y90 followed by hepatectomy (2008-2017). Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.366DOI Listing

Long term outcome after minimally invasive and open Warshaw and Kimura techniques for spleen-preserving distal pancreatectomy: International multicenter retrospective study.

Eur J Surg Oncol 2019 Apr 8. Epub 2019 Apr 8.

General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona Hospital, Verona, Italy. Electronic address:

Background: The Warshaw (WT) and the Kimura (KT) techniques are both used for open or minimally invasive (MI) spleen preserving distal pancreatectomy (SPDP). Multicenter studies on long-term outcome of WT and KT are lacking.

Methods: Multicenter retrospective study with transversal follow-up moment, including patients who underwent SPDP from 2000 to 2017 at three high-volume centers in Italy and the Netherlands. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.04.004DOI Listing

Effect of infarct site on the clinical endpoints of thrombolytic-treated ST-elevation myocardial infarction.

Am J Emerg Med 2019 Apr 12. Epub 2019 Apr 12.

Division of Cardiovascular Medicine, University of Missouri Health Care, Columbia, MO, USA. Electronic address:

Introduction: Some studies suggest better outcomes after the use of thrombolytics in inferior ST-elevation myocardial infarction (STEMI) compared to other locations. The goal of this study is to compare the clinical endpoints of thrombolytic-treated STEMI based on coronary artery distribution.

Methods: The study population was extracted from the 2014 Nationwide Readmissions Data using the International Classification of Diseases, Ninth Revision, Clinical Modifications codes for STEMI, thrombolytic infusion, and complications of STEMI. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.04.026DOI Listing

Trends of antenatal care during pregnancy in low- and middle-income countries: Findings from the global network maternal and newborn health registry.

Semin Perinatol 2019 Mar 16. Epub 2019 Mar 16.

Columbia University, New York, NY, United States.

Background: Antenatal care (ANC) is an important opportunity to diagnose and treat pregnancy-related complications and to deliver interventions aimed at improving health and survival of both mother and the infant. Multiple individual studies and national surveys have assessed antenatal care utilization at a single point in time across different countries, but ANC trends have not often been studied in rural areas of low-middle income countries (LMICs). The objective of this analysis was to study the trends of antenatal care use in LMICs over a seven-year period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01460005193004
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http://dx.doi.org/10.1053/j.semperi.2019.03.020DOI Listing
March 2019
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Bleeding risk assessment for stroke patients on antithrombotic therapy.

Clin Investig Arterioscler 2019 Apr 17. Epub 2019 Apr 17.

Unidad de Gestión Clínica de Cuidados Críticos y Urgencias, Hospital Virgen Macarena, Sevilla, España.

Introduction: After an ischemic cerebrovascular event the risk of new ischemic events is high, therefore antithrombotic therapy are indicated to prevent stroke recurrence.

Discussion: Despite its clear benefit, these therapies increase the risk of bleeding. Therefore, it is essential to identify high hemorrhagic risk patients. Read More

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http://dx.doi.org/10.1016/j.arteri.2019.01.006DOI Listing

Safety Assessment of Immune-Mediated Adverse Reactions to Novel Food Proteins.

Trends Biotechnol 2019 Apr 17. Epub 2019 Apr 17.

Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM), C/ Nicolás Cabrera, 9, Campus de la Universidad Autónoma de Madrid, 28049 Madrid, Spain.

Current international guidelines for the risk assessment of biotechnology-derived foods date back to 2003. We present new strategies and directions for assessing immune adverse reactions to novel food proteins. Understanding genetic factors involved in food allergy and the role of the gastrointestinal tract will streamline risk assessment strategies. Read More

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http://dx.doi.org/10.1016/j.tibtech.2019.03.010DOI Listing

Infectious human papillomavirus virions in semen reduce clinical pregnancy rates in women undergoing intrauterine insemination.

Fertil Steril 2019 Apr 17. Epub 2019 Apr 17.

Genk Institute for Fertility Technology, ZOL Hospitals, Genk, Belgium; Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.

Objective: To study the influence of human papillomavirus (HPV) virions present in different sperm fractions of male partners of women undergoing IUI on fertility outcome.

Design: Prospective noninterventional multicenter study.

Setting: Inpatient hospital fertility centers. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2019.02.002DOI Listing

An international, phase III randomized trial in patients with mucinous epithelial ovarian cancer (mEOC/GOG 0241) with long-term follow-up: and experience of conducting a clinical trial in a rare gynecological tumor.

Gynecol Oncol 2019 Apr 17. Epub 2019 Apr 17.

The University of Texas MD Anderson Cancer Centre, Houston, TX, USA.

Objectives: We evaluated four different treatment regimens for advanced-stage mucinous epithelial ovarian cancer.

Methods: We conducted a multicenter randomized factorial trial (UK and US). Patients were diagnosed with primary mEOC: FIGO stage II-IV or recurrence after stage I disease. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.03.256DOI Listing

HPV detection and genotyping of head and neck cancer biopsies by molecular testing with regard to the new oropharyngeal squamous cell carcinoma classification based on HPV status.

Pathology 2019 Apr 17. Epub 2019 Apr 17.

Laboratoire de virologie, Hôpital Européen Georges Pompidou, and Assistance Publique - Hôpitaux de Paris, Paris, France; Faculté de Médecine Paris Descartes, Université Paris Descartes (Paris V), Sorbonne Paris Cité, Paris, France. Electronic address:

Recently, both the World Health Organization/International Agency for Research on Cancer (WHO/IARC) and the American Joint Committee on Cancer (AJCC) have classified oropharyngeal squamous cell carcinoma (OPSCC) on the basis of HPV status. For this purpose, the WHO/IARC recommended direct molecular HPV testing. In practice, formalin-fixed, paraffin-embedded (FFPE) biopsy specimens are frequently the only available samples. Read More

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http://dx.doi.org/10.1016/j.pathol.2019.02.002DOI Listing

Nodal failure after chemo-radiation and MRI guided brachytherapy in cervical cancer: Patterns of failure in the EMBRACE study cohort.

Radiother Oncol 2019 May 26;134:185-190. Epub 2019 Feb 26.

Department of Radiation Oncology, University Medical Center Utrecht, the Netherlands. Electronic address:

Purpose/objective(s): To investigate the patterns of nodal failure in patients enrolled in the international multicentre EMBRACE study.

Materials/methods: Nodal disease at diagnosis (N-, N+) and nodal failure were analysed per region (NF) (pelvic (parametrial, common iliac, internal/external iliac), inguinal and para-aortic (PAO)) in 1338 patients. Treatment consisted of chemo-radiation and MRI guided brachytherapy. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.02.007DOI Listing

Does higher field strength translate into better diagnostic accuracy? A prospective comparison of breast MRI at 3 and 1.5 Tesla.

Eur J Radiol 2019 May 28;114:51-56. Epub 2019 Feb 28.

Department of Biomedical Imaging and Image-Guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Waehringer-Guertel 18-20, Vienna, Austria. Electronic address:

Objective: We performed a prospective monocentric study to inter-individually compare the diagnostic accuracy of breast MRI at 1.5 T and 3 T.

Methods: During a consecutive period of 12 months all 982 patients receiving breast MRI according to standard indications (problem solving, preoperative staging) were randomized to one 3 T or 1. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.02.033DOI Listing
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