3 results match your criteria International Journal of Organic Chemistry

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Synthesis and Chiral Separation of Fibratol, Isopropyl 2-(4-((4-chlorophenyl)(hydroxyl) methyl)-phenoxy)-2-methylpropanoate.

Int J Org Chem (Irvine) 2018 Jun 30;8(2):201-206. Epub 2018 May 30.

Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USA.

Practical synthetic route for the formation of enantiomeric mixture of Isopropyl 2-(4-((4-chlorophenyl)(hydroxyl)methyl)phenoxy)-2-methylpropanoate (Fibratol 2a/b) from isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate (Fenofibrate 1) has been developed. Method has also been established for the chiral separation of enantiomers of Fibratol 2a/b that is synthesized using the route mentioned above. The optical activity determined for enantiomerically separated Fibratol (2a) and Fibratol (2b) are -5. Read More

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http://dx.doi.org/10.4236/ijoc.2018.82015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078423PMC
June 2018
2 Reads

Microwave Application and Anhydrous Cu(OAc) Mediated O-Arylation of Aliphatic Amino Alcohols.

Int J Org Chem (Irvine) 2016 Jun 27;6(2):100-106. Epub 2016 May 27.

Department of Chemistry, Tennessee State University, Nashville, TN, USA.

Anhydrous Cu(OAc) mediated efficient protocol has been developed in the area of C-O coupling from potassium aryltrifluoroborates and aliphatic amino alcohols such as β-hydroxy, γ-hydroxy, and δ-hydroxy amines. The scope of this transformation focuses on direct O-arylation and Ostyrylation. The reaction vial loaded with reactants under argon atmosphere is microwaved at 140°C for 30 min to furnish the corresponding cross-coupling product, amino ethers, in good yields. Read More

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http://dx.doi.org/10.4236/ijoc.2016.62011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654586PMC
June 2016
3 Reads

Synthesis of a Fluorophore with Improved Optical Brightness.

Int J Org Chem (Irvine) 2013 Dec;3(4):256-261

Chemistry Department, Doane College, Crete, USA.

The synthesis and characterization of a novel fluorophore(), with potential application as an optical brightener are reported. This compound was prepared by reacting 4,4-diaminostilbene-2,2-disulfonic acid with cyanuric chloride in the presence of NaCO followed by the addition of trityl aniline. Solution and solid state fluorescence demonstrated a strong blue/purple emission centered at 450 nm. Read More

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http://dx.doi.org/10.4236/ijoc.2013.34037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241686PMC
December 2013
18 Reads
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