19,508 results match your criteria International Journal of Oral & Maxillofacial Implants [Journal]


Epidemiology and resource utilization of ludwig angina ED visits in the United States 2006-2014.

Laryngoscope 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgery, Division of Otolaryngology/Head & Neck Surgery, Howard University College of Medicine, Washington, District of Columbia, U.S.A.

Objectives: Ludwig angina is a potentially lethal submandibular space infection. We aim to describe the epidemiological characteristics of Ludwig angina patients presenting to the emergency department (ED) and to examine outcomes and resource utilization to determine their burden on ED and hospitals.

Methods: Using the Nationwide Emergency Department Sample database, a nationally representative all-payer database, we retrospectively reviewed all ED visits between 2006 and 2014 for patients admitted with a primary diagnosis of Ludwig angina (International Classification of Diseases, Ninth Revision, 528. Read More

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http://dx.doi.org/10.1002/lary.27734DOI Listing
February 2019

[The content of publications in the Netherlands Journal of Dentistry - an analysis of patterns over time].

Ned Tijdschr Tandheelkd 2019 Feb;126(2):91-100

In 2018, the Netherlands Journal of Dentistry (NTVT) had been published for 125 years: reason for a systematic look at the subjects that have received attention since 2000. These subjects were subsequently compared to those in Dutch dental publications in international literature and to leading fields in oral health care. The analysis revealed an increase in the attention given to certain fields in the Netherlands Journal of Dentistry, such as public dental health, during the past 18 years and a decrease in the attention given to other subjects, such as basic scientific research. Read More

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http://dx.doi.org/10.5177/ntvt.2019.02.18242DOI Listing
February 2019

Ginseng Extract Modified by Pectin Lyase Inhibits Retinal Vascular Injury and Blood-Retinal Barrier Breakage in a Rat Model of Diabetes.

J Med Food 2019 Feb 20. Epub 2019 Feb 20.

2 Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.

GS-E3D is an enzymatically modified ginseng extract by pectin lyase. In this study, we evaluated the preventive effects of GS-E3D on blood-retinal barrier (BRB) leakage in a rat model of diabetes. To produce diabetes, rats were injected with streptozotocin. Read More

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http://dx.doi.org/10.1089/jmf.2018.4256DOI Listing
February 2019

Flower-like FeS/BiS superstructures with improved near-infrared absorption for efficient chemo-photothermal therapy.

Dalton Trans 2019 Feb 20. Epub 2019 Feb 20.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-dimension Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P.R. China. and College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen 518118, China.

Although various photothermal therapy (PTT) nanoagents have been developed in recent years, the rational design and easy synthesis of a PTT nanoplatform with improved near-infrared (NIR) absorption have remained challenging. Herein, via a facile one-pot solvothermal strategy, hydrophilic nanosheet-assembled flower-like Fe7S8/Bi2S3 superstructures were fabricated successfully. Such nanoflowers exhibit improved NIR absorption, which is 1. Read More

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http://dx.doi.org/10.1039/c8dt04280bDOI Listing
February 2019

Inhibitory effect of valproate sodium on pain behavior in diabetic mice involves suppression of spinal histone deacetylase 1 and inflammatory mediators.

Int Immunopharmacol 2019 Feb 18;70:16-27. Epub 2019 Feb 18.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. Electronic address:

Anti-epileptic medications are included in the international guidelines for managing neuropathic pain. Valproate sodium (VPS) was recently described as "the forgotten analgesic" and has been reported to relief pain in various models of neuropathic pain. Some studies reported anti-inflammatory and histone deacetylase 1 (HDA1) inhibitory properties for sodium valproate. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.050DOI Listing
February 2019

Is placing a victim in the left lateral decubitus position an effective first aid intervention for acute oral poisoning? A systematic review.

Clin Toxicol (Phila) 2019 Feb 20:1-14. Epub 2019 Feb 20.

a Centre for Evidence-Based Practice (CEBaP) , Belgian Red Cross, Mechelen , Belgium.

Introduction: In acute oral poisoning, any first aid intervention that limits or delays the uptake of the ingested substance, and which can be performed by bystanders as first responders, might assist in reducing morbidity if a toxic substance has been ingested. The current recommendation by the International Federation of Red Cross/Red Crescent Societies is to place a victim in the left lateral decubitus position.

Objective: The aim of this PRISMA compliant systematic review is to assess whether the current recommendation by the International Federation of Red Cross/Red Crescent Societies decreases or delays the absorption of an orally ingested poison. Read More

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http://dx.doi.org/10.1080/15563650.2019.1574975DOI Listing
February 2019

[Frequency and management of complex facial fractures-an oral and maxillofacial surgical assessment].

Unfallchirurg 2019 Feb 19. Epub 2019 Feb 19.

Klinik für Mund‑, Kiefer- und Gesichtschirurgie, Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland.

Introduction: The treatment of facial fractures is an integral part of the oral and maxillofacial surgical treatment spectrum. In the case of complex fractures that involve multiple levels of the facial skeleton associated with severe concomitant injuries, an individual and interdisciplinary treatment approach is needed, which requires the infrastructure of a national trauma center.

Objective: The aim of this study was to analyze the incidence and management of patients with complex facial fractures and considering the concomitant injury pattern. Read More

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http://dx.doi.org/10.1007/s00113-019-0618-8DOI Listing
February 2019

Understanding the manifestation of diabetes in sub Saharan Africa to inform therapeutic approaches and preventive strategies: a narrative review.

Clin Diabetes Endocrinol 2019 14;5. Epub 2019 Feb 14.

Non-Communicable Diseases Theme, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Plot 51-59, Nakiwogo Road, P.O. BOX 49 Entebbe, Uganda.

Background: Globally, the burden of diabetes mellitus has increased to epidemic proportions. Estimates from the International Diabetes Federation predict that the greatest future increase in the prevalence of diabetes mellitus will occur in Africa.

Methods: This article reviews literature on the manifestation of diabetes in adult patients in sub-Saharan Africa highlighting the distinct phenotypes, plausible explanations for this unique manifestation and the clinical significance of comprehensively defining and understanding the African diabetes phenotype. Read More

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http://dx.doi.org/10.1186/s40842-019-0077-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376682PMC
February 2019

Effects of maternal B12 supplementation on neurophysiological outcomes in children: a study protocol for an extended follow-up from a placebo randomised control trial in Bangalore, India.

BMJ Open 2019 Feb 19;9(2):e024426. Epub 2019 Feb 19.

St John's Research Institute, St John's National Academy of Health Sciences, Bangalore, Karnataka, India.

Introduction: Vitamin B12 deficiency is highly prevalent in pregnant Indian women. Neuropsychological tests have shown an association between low maternal vitamin B12 status and poorer cognitive performances in the offspring, although findings from these studies have been inconsistent. Vitamin B12 has an important role in the formation of myelin which is important for the transmission speed of neural impulses and myelination in the central nervous system has been linked to cognition. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024426DOI Listing
February 2019

Study protocol for an open-label, single-arm, multicentre phase II trial to evaluate the efficacy and safety of combined triplet therapy and olanzapine for prevention of carboplatin-induced nausea and vomiting in gynaecological cancer patients.

BMJ Open 2019 Jan 17;9(1):e024357. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, Gifu, Japan.

Introduction: Carboplatin (CBDCA) administered at a dosage of 4 mg/mL/min or more area under the blood concentration-time curve (AUC) is considered to be ranked as the highest chemotherapy-induced nausea and vomiting (CINV) risk of the moderately emetogenic chemotherapy agents. The complete response (CR) rate for preventing overall CINV, defined as no emetic episodes and no use of rescue medication, for standard triplet antiemetic therapy (5-HTRA, 5-hydroxytryptamine-3 receptor antagonist; NKRA, neurokinin-1 receptor antagonist; DEX, dexamethasone) was approximately 60% in gynaecological cancer patients receiving CBDCA-based therapy. Further improvement in antiemetic treatment is needed to optimise care. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024357DOI Listing
January 2019

A prospective cohort for the investigation of alteration in temporal transcriptional and microbiome trajectories preceding preterm birth: a study protocol.

BMJ Open 2019 Jan 15;9(1):e023417. Epub 2019 Jan 15.

Sidra Medicine, Doha, Qatar.

Introduction: Preterm birth (PTB) results from heterogeneous influences and is a major contributor to neonatal mortality and morbidity that continues to have adverse effects on infants beyond the neonatal period. This protocol describes the procedures to determine molecular signatures predictive of PTB through high-frequency sampling during pregnancy, at delivery and the postpartum period.

Methods And Analysis: Four hundred first trimester pregnant women from either Myanmar or Thailand of either Karen or Burman ethnicity, with a viable, singleton pregnancy will be enrolled in this non-interventional, prospective pregnancy birth cohort study and will be followed through to the postpartum period. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023417DOI Listing
January 2019

Comparison of Er,Cr:YSGG and diode laser effects on dentin hypersensitivity: a split-mouth randomized clinical trial.

Clin Oral Investig 2019 Feb 18. Epub 2019 Feb 18.

Tehran University of Medical Sciences Research Center, Tehran, Iran.

Objectives: The aim of the present study was to compare the clinical efficacy of diode laser and Er,Cr:YSGG lasers in the treatment of dentin hypersensitivity.

Materials And Methods: Thirty-four teeth from 17 patients with dentin hypersensitivity were divided into two groups. In group D, the teeth were irradiated with diode laser beams with a wavelength of 940 nm for 1 min, and in group E, the teeth were irradiated with Er,Cr:YSGG laser beams with a wavelength of 2780 nm and a pulse width of 140-200 μs. Read More

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http://dx.doi.org/10.1007/s00784-019-02841-zDOI Listing
February 2019

In vitro activity of the novel oral antimicrobial SMT-571, with a new mechanism of action, against MDR and XDR Neisseria gonorrhoeae: future treatment option for gonorrhoea?

J Antimicrob Chemother 2019 Feb 18. Epub 2019 Feb 18.

WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, National Reference Laboratory for Sexually Transmitted Infections, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Background: Lack of effective treatment of gonorrhoea due to increasing antimicrobial resistance in Neisseria gonorrhoeae is a serious threat to the management and control of the infection. Novel antimicrobials are required to prevent the infection becoming untreatable.

Objectives: Herein, we investigated the in vitro activity of a novel small-molecule antimicrobial with a new mechanism of action, SMT-571, against a large collection of clinical N. Read More

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http://dx.doi.org/10.1093/jac/dkz060DOI Listing
February 2019

The role of oral magnesium supplements for the management of stable bronchial asthma: a systematic review and meta-analysis.

NPJ Prim Care Respir Med 2019 Feb 18;29(1). Epub 2019 Feb 18.

King Saud bin Abdul-Aziz University for Health Sciences; National & Gulf Center for Evidence Based Health Practice, King Abdullah International Medical Research Center, Family Medicine & Primary Healthcare Department, King Abdul-Aziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.

Asthma is a chronic lung disease characterized by airway inflammation and hyper-responsiveness of airway smooth muscles. There is growing evidence that magnesium may have a role in managing asthma through its dual effect as an anti-inflammatory and bronchodilating agent. To assess the efficacy of oral magnesium supplements in chronic asthmatic patients. Read More

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http://dx.doi.org/10.1038/s41533-019-0116-zDOI Listing
February 2019

Carcinogenicity of smokeless tobacco: Evidence from studies in humans & experimental animals.

Indian J Med Res 2018 Dec;148(6):681-686

Section of Evidence Synthesis and Classification, International Agency for Research on Cancer, Lyon, France.

A Working Group of the Monographs programme of the International Agency for Research on Cancer has classified smokeless tobacco as carcinogenic to humans (Group 1). This review article summarizes the data that support the evaluations of sufficient evidence in humans and in experimental animals for the carcinogenicity of smokeless tobacco whether used alone or with betel quid. It also identifies compounds of smokeless tobacco relevant to carcinogenicity (prominently tobacco-specific nitrosamines) and addiction (nicotine). Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_149_18DOI Listing
December 2018

Impact of two oral doses of 100,000 IU of vitamin D in preschoolers with viral-induced asthma: a pilot randomised controlled trial.

Trials 2019 Feb 18;20(1):138. Epub 2019 Feb 18.

Clinical Research and Knowledge Transfer Unit on Childhood Asthma, Research Centre, Sainte-Justine University Health Centre, Montreal, Quebec, Canada.

Background: New evidence supports the use of supplemental vitamin D in the prevention of exacerbation of asthma; however, the optimal posology to sufficiently raise serum levels while maximising adherence is unclear. The objective was to ascertain the efficacy of high-dose vitamin D in increasing serum vitamin D in preschoolers with asthma and provide preliminary data on safety and efficacy outcomes.

Methods: We conducted a 7-month, triple-blind, randomised, placebo-controlled, pilot trial of children aged 1-5 years with viral-induced asthma. Read More

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http://dx.doi.org/10.1186/s13063-019-3184-zDOI Listing
February 2019

Apremilast in Psoriasis and Beyond: Big Hopes on a Small Molecule.

Indian Dermatol Online J 2019 Jan-Feb;10(1):1-12

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Apremilast, an orally administered small molecule inhibitor of phosphodiesterase 4 (PDE4), has been licensed by the US Food and Drug Administration for the management of active psoriatic arthritis (March 21, 2014) and moderate to severe plaque psoriasis (September 23, 2014). It has got approval from Drug Controller General of India for marketing in India in 2017. The drug has drawn much attention from the practising dermatologists for its commendable safety profile and prescription convenience. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_437_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362739PMC
February 2019

Safety and efficacy of lixisenatide versus sulfonylurea added to basal insulin treatment in people with type 2 diabetes mellitus who elect to fast during Ramadan (LixiRam): An international, randomized, open-label trial.

Diabetes Res Clin Pract 2019 Feb 14. Epub 2019 Feb 14.

University Hospital Birmingham & Institute of Translational Medicine, Edgbaston, Birmingham, UK. Electronic address:

Aims: Adding lixisenatide to basal insulin (BI) instead of sulfonylurea (SU), versus continuing SU + BI was assessed in people with type 2 diabetes mellitus (T2DM) who intended to fast during Ramadan 2017.

Methods: LixiRam (NCT02941367) was a phase 4, randomized, open-label, 12-22-week study in people with T2DM insufficiently controlled with SU + BI ± 1 oral anti-diabetic. Endpoints included the percentage of participants with ≥1 documented symptomatic hypoglycemia event (plasma glucose ≤70 mg/dL; primary endpoint) and any hypoglycemia during Ramadan fasting. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.035DOI Listing
February 2019

Acute and sub-acute toxicity of the aqueous extract from the stem bark of Tetrapleura tetrapteura Taub. (Fabaceae) in mice and rats.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

H.E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Biochemistry, Dr. Panjwani Center for Molecular Medicine and Drug Research (P.C.M.D.), International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address:

Ethnopharmacological Relevance: Tetrapleura tetrapteura Taub. is a leguminous multipurpose tree (Fabaceae) indigenous to tropical Africa. Fruits, seeds and stem bark infusions or decoctions of Tetrapleura tetrapteura Taub. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.026DOI Listing
February 2019

The impact of improved water, sanitation and hygiene on oral rotavirus vaccine immunogenicity in Zimbabwean infants: sub-study of a cluster-randomized trial.

Clin Infect Dis 2019 Feb 16. Epub 2019 Feb 16.

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

Background: Oral vaccines have lower efficacy in developing compared to developed countries. Poor water, sanitation and hygiene (WASH) may contribute to reduced oral vaccine immunogenicity.

Methods: We conducted a cluster-randomized 2x2 factorial trial in rural Zimbabwe (NCT01824940). Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
Publisher Site
http://dx.doi.org/10.1093/cid/ciz140DOI Listing
February 2019
1 Read

Three-dimensional assessment of proximal contact enamel using optical coherence tomography.

Dent Mater 2019 Feb 12. Epub 2019 Feb 12.

Department of Cariology and Operative Dentistry, Division of Oral Health Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Objective: The purpose of this study was to detect and investigate the association of enamel microcracks with demineralization at proximal contact areas of premolars, using 3D swept-source optical coherence tomography (SS-OCT).

Methods: Extracted maxillary and mandibular premolars (n=50 each), without any visible tooth cracks, were examined for demineralization of interproximal contact areas, using the International Caries Detection and Assessment System (ICDAS). SS-OCT was used to evaluate demineralization and detect microcracks. Read More

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http://dx.doi.org/10.1016/j.dental.2019.01.008DOI Listing
February 2019

Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications.

Br J Anaesth 2019 Mar 8;122(3):361-369. Epub 2019 Feb 8.

Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Università degli Studi di Genova, Genova, Italy; IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Background: The aim of this post hoc analysis of a large cohort study was to evaluate the association between night-time surgery and the occurrence of intraoperative adverse events (AEs) and postoperative pulmonary complications (PPCs).

Methods: LAS VEGAS (Local Assessment of Ventilatory Management During General Anesthesia for Surgery) was a prospective international 1-week study that enrolled adult patients undergoing surgical procedures with general anaesthesia and mechanical ventilation in 146 hospitals across 29 countries. Surgeries were defined as occurring during 'daytime' when induction of anaesthesia was between 8:00 AM and 7:59 PM, and as 'night-time' when induction was between 8:00 PM and 7:59 AM. Read More

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http://dx.doi.org/10.1016/j.bja.2018.10.063DOI Listing
March 2019
1 Read

Bioactivity Determination of a Therapeutic Recombinant Human Keratinocyte Growth Factor by a Validated Cell-based Bioassay.

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

National Institutes for Food and Drug Control, No. 2, Tiantan Xili, Dongcheng District, Beijing 100050, China.

The therapeutic recombinant human keratinocyte growth factor 1 (rhKGF-1) was approved by the FDA for oral mucositis resulting from hematopoietic stem cell transplantation for hematological malignancies in 2004. However, no recommended bioassay for rhKGF-1 bioactivity has been recorded in the U.S. Read More

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http://dx.doi.org/10.3390/molecules24040699DOI Listing
February 2019

Assessment of voluntary HIV screening for asylum seekers in two Swiss cantons.

Swiss Med Wkly 2019 Feb 15;149:w20020. Epub 2019 Feb 15.

Department of Infectious Diseases, Central Institute, Valais Hospital, Sion, Switzerland / Departments of Infectious Diseases and of Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.

Objective: To evaluate the feasibility of HIV screening, offered to newly arrived asylum seekers in the Swiss cantons of Valais (VS) and Vaud (VD) in order to meet the national and international standards for early detection and effective treatment of HIV infections.

Methods: HIV screening was offered free of charge to every asylum seeker who arrived from June 2015 to November 2016 in VS, and from June to October 2016 in VD. Pregnant women and children <16 were excluded. Read More

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http://dx.doi.org/10.4414/smw.2019.20020DOI Listing
February 2019

Frequency and risk factors for recurrent gestational diabetes mellitus in primiparous women: a case control study.

BMC Endocr Disord 2019 Feb 15;19(1):22. Epub 2019 Feb 15.

The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, No. 1961, Huashan Road, Shanghai, 200030, China.

Background: To investigate the frequency and risk factors for recurrent gestational diabetes mellitus (GDM) in Chinese primiparous women.

Methods: Case control study. We investigated primiparous women who experienced GDM complications and had a subsequent pregnancy in the same hospital from January, 2012 to January, 2017. Read More

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http://dx.doi.org/10.1186/s12902-019-0349-4DOI Listing
February 2019

Antidiabetic properties of aqueous and methanol extracts from the trunk bark of Ceiba pentandra in type 2 diabetic rat.

J Cell Biochem 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon.

The type 2 diabetes is one of the major global health issues that affects millions of people. This study evaluated the antidiabetic activity of aqueous extracts (AECP) and methanol extracts (MECP) from Ceiba pentandra trunk bark on an experimental model of type 2 diabetes (T2D). This model was induced in rats by the combination of a high-fat diet (HFD) and a single dose of streptozotocin (40 mg/kg, intraperitoneal) at the seventh day of experimentation. Read More

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http://dx.doi.org/10.1002/jcb.28437DOI Listing
February 2019
3.263 Impact Factor

Overview of the Typhoid Conjugate Vaccine Pipeline: Current Status and Future Plans.

Clin Infect Dis 2019 Feb;68(Supplement_1):S22-S26

International Vaccine Institute, Seoul, Republic of Korea.

Typhoid fever remains a common and serious disease in populations that live in low- and middle-income countries. Treatment usually consists of antibiotics, but problems with drug-resistant strains have been increasing in endemic countries, making treatment prolonged and costly. Improved sanitation and food hygiene have been effective in controlling the disease in the industrialized world, but these steps are associated with socioeconomic progress that has been slow in most of the affected areas. Read More

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https://academic.oup.com/cid/article/68/Supplement_1/S22/532
Publisher Site
http://dx.doi.org/10.1093/cid/ciy884DOI Listing
February 2019
2 Reads

Immune checkpoint inhibitors: Real-world experience from India in advanced solid cancers that have progressed on chemotherapy.

South Asian J Cancer 2019 Jan-Mar;8(1):65-68

Department of Medical Oncology, Max Super Speciality Hospital, New Delhi, India.

Context: The immune checkpoint inhibitors (ICIs) nivolumab and pembrolizumab have shown dramatic efficacy with low toxicity in international studies of advanced solid cancers. No published Indian experience with ICIs exist other than isolated case reports.

Aims: The aim of this study is to evaluate real-world data about the efficacy and toxicity of ICIs in advanced solid cancers among Indian patients who have progressed on one or more prior lines of chemotherapy. Read More

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http://dx.doi.org/10.4103/sajc.sajc_167_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348784PMC
February 2019

Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine.

Curr Ther Res Clin Exp 2019 12;90:9-15. Epub 2019 Jan 12.

Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology University of Copenhagen and Department of Clinical Microbiology and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.

Background: There is limited information on the safety or efficacy of currently recommended antimalarial drugs in patients with sickle cell disease (SCD), a population predisposed to worse outcomes if affected by acute malaria. Artesunate-amodiaquine (ASAQ) is the first-line treatment for uncomplicated malaria (UM) in many malaria-endemic countries and is also used for treatment of UM in SCD patients. There is, however, no information to date, on the pharmacokinetics (PK) of amodiaquine or artesunate or the metabolites of these drugs in SCD patients. Read More

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http://dx.doi.org/10.1016/j.curtheres.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360331PMC
January 2019

Management of non-syndromic craniosynostoses in France in 2015: A national survey.

J Craniomaxillofac Surg 2019 Jan 30. Epub 2019 Jan 30.

Department of Plastic and Oral and Maxillofacial Surgery, Caen University Hospital, Avenue de la Côte-de-Nacre, 14000 Caen, France. Electronic address:

Purpose: Craniosynostoses are managed by surgical and anaesthetic teams in specialist centres. Despite the availability of international guidelines, the perioperative management of craniosynostoses remains highly variable between centres. The aim of our study was to describe the different protocols for the management of non-syndromic craniosynostoses in France in 2015. Read More

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http://dx.doi.org/10.1016/j.jcms.2019.01.028DOI Listing
January 2019

Organization and implementation of an oral cholera vaccination campaign in an endemic urban setting in Dhaka, Bangladesh.

Glob Health Action 2019 ;12(1):1574544

b Infectious Diseases Division , International Centre for Diarrhoeal Disease Research (ICDDR) , Dhaka , Bangladesh.

Bangladesh has historically been cholera endemic, with seasonal cholera outbreaks occurring each year. In collaboration with the government of Bangladesh, the Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) initiated operational research to test strategies to reach the high-risk urban population with an affordable oral cholera vaccine (OCV) "ShancholTM" and examine its effectiveness in reducing diarrhea due to cholera. Here we report a sub-analysis focusing on the organization, implementation and effectiveness of different oral cholera vaccine delivery strategies in the endemic urban setting in Bangladesh. Read More

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http://dx.doi.org/10.1080/16549716.2019.1574544DOI Listing
January 2019
3 Reads

Quality of Life Related to Oral Health and its Impact in Adults.

J Stomatol Oral Maxillofac Surg 2019 Feb 11. Epub 2019 Feb 11.

MD DDS, PhD. Doctor, Specialist in Stomatology. Professor of Oral Pathology, Faculty of Medicine and Health Sciences (School of Dentistry), Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute), IDIBELL, University of Barcelona, Departament of OdontoestomatologySecond Floor, Room 2.32, Faculty of Medicine and Health Sciences - School of Dentistry Campus Bellvitge, University of Barcelona, Spain.

Oral health is part of general health, and is recognized as an essential component of quality of life (QoL). For years, oral health was determined solely by the clinic, which did not allow an evaluation of the true impact of oral diseases on the patients' daily lives. The development of instruments for assessing QoL related to oral health has occurred due to the urgency of determining the effects of changes in the oral cavity of individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687855193004
Publisher Site
http://dx.doi.org/10.1016/j.jormas.2019.02.004DOI Listing
February 2019
1 Read

A prescription support-tool for chronic management of oral antithrombotic combinations in adults based on a systematic review of international guidelines.

PLoS One 2019 14;14(2):e0211695. Epub 2019 Feb 14.

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpital Pitié-Salpêtrière, Département Biostatistique Santé Publique et Information Médicale, Unité de Recherche Clinique PSL-CFX, Centre de Pharmacoépidémiologie (Cephepi), Paris, France.

Background: Oral antithrombotic (AT) drugs, which include antiplatelet and anticoagulant therapies, are widely implicated in serious preventable bleeding events. Avoiding inappropriate oral AT combinations is a major concern. Numerous practical guidelines have been released; a document to enhance prescriptions of oral AT combinations for adults would be of great help. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211695PLOS
February 2019

Recommendations of the Advisory Committee on Immunization Practices for Use of Hepatitis A Vaccine for Persons Experiencing Homelessness.

MMWR Morb Mortal Wkly Rep 2019 Feb 15;68(6):153-156. Epub 2019 Feb 15.

Hepatitis A (HepA) vaccination is recommended routinely for children at age 12-23 months, for persons who are at increased risk for hepatitis A virus (HAV) infection, and for any person wishing to obtain immunity. Persons at increased risk for HAV infection include international travelers to areas with high or intermediate hepatitis A endemicity, men who have sex with men, users of injection and noninjection drugs, persons with chronic liver disease, person with clotting factor disorders, persons who work with HAV-infected primates or with HAV in a research laboratory setting, and persons who anticipate close contact with an international adoptee from a country of high or interme-diate endemicity (1-3). Persons experiencing homelessness are also at higher risk for HAV infection and severe infection-associated outcomes. Read More

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http://www.cdc.gov/mmwr/volumes/68/wr/mm6806a6.htm?s_cid=mm6
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http://dx.doi.org/10.15585/mmwr.mm6806a6DOI Listing
February 2019
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Effects of therapeutic plasma exchange on anticoagulants in patients receiving therapeutic anticoagulation: a systematic review.

Transfusion 2019 Feb 14. Epub 2019 Feb 14.

Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.

Therapeutic plasma exchange (TPE) removes coagulation proteins, but its impact on therapeutic anticoagulation is unknown. We performed a systematic review of the literature to determine the coagulation effects of TPE in patients receiving systemic anticoagulation. We searched MEDLINE, CINAHL, EMBASE, and Web of Science until June 2018 for studies combining controlled vocabulary and keywords related to therapeutic plasma exchange, plasmapheresis, anticoagulants, and therapy. Read More

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http://dx.doi.org/10.1111/trf.15191DOI Listing
February 2019

The heterogeneous nature of water well fluoride levels in Sri Lanka: An opportunity to mitigate the dental fluorosis.

Community Dent Oral Epidemiol 2019 Feb 13. Epub 2019 Feb 13.

International Research Collaborative - Oral Health And Equity, School of Human Sciences, The University of Western Australia, Crawley, Perth, Western Australia, Australia.

Objectives: The study aimed to use Geographic Information Systems (GIS) to investigate the spatial distribution of the concentration of fluoride (F) in groundwater resources of Sri Lanka, and the geographic accessibility to an alternative water source having a low or safe F limit to mitigate dental fluorosis.

Methods: The study used randomly collected (6107) groundwater samples from Sri Lanka and categorized them as "dentally optimal" and "unsafe" based on their F content. The minimum distance from an identified high F source (above dentally optimal level) to a safe groundwater source was determined using geospatial analysis. Read More

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http://dx.doi.org/10.1111/cdoe.12449DOI Listing
February 2019
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Surface Dissolution UV Imaging for Investigation of Dissolution of Poorly Soluble Drugs and Their Amorphous Formulation.

AAPS PharmSciTech 2019 Feb 13;20(3):113. Epub 2019 Feb 13.

Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

The aim of this study is to investigate the dissolution properties of poorly soluble drugs from their pure form and their amorphous formulation under physiological relevant conditions for oral administration based on surface dissolution ultraviolet (UV) imaging. Dissolution of two poorly soluble drugs (cefuroxime axetil and itraconazole) and their amorphous formulations (Zinnat and Sporanox) was studied with the Sirius Surface Dissolution Imager (SDI). Media simulating the fasted state conditions (compendial and biorelevant) with sequential media/flow rate change were used. Read More

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http://dx.doi.org/10.1208/s12249-019-1317-zDOI Listing
February 2019
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[Severe coagulation abnormality during treatment for ischemic enteritis in an older patient taking a direct oral anticoagulant].

Nihon Ronen Igakkai Zasshi 2019 ;56(1):74-78

Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center.

An 85-year-old woman hospitalized for rehabilitation after cerebral infarction developed persistent bloody diarrhea and was transferred to our hospital (day 1). Contrast-enhanced computed tomography of the abdomen showed edematous thickening extending from the left side of the transverse colon to the rectum, with decreased mucosal enhancement. She was diagnosed with ischemic enteritis. Read More

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https://www.jstage.jst.go.jp/article/geriatrics/56/1/56_56.7
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http://dx.doi.org/10.3143/geriatrics.56.74DOI Listing
January 2019
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Associations Between Serum Uric Acid Levels and Cardiometabolic Risk, Renal İnjury in Obese and Overweight Children

J Clin Res Pediatr Endocrinol 2019 Feb 14. Epub 2019 Feb 14.

Manisa Celal Bayar University, School of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Manisa, Turkey

Objective: In this study we aimed to assess the association between serum uric acid (SUA) concentration and metabolic syndrome (MetS) parameters and insulin resistance (IR). Our second aim was evaluate whether hyperuricemia is related with renal injury and cardiovascular risk in obese (OB) and overweight(OW) children.

Methods: This study was conducted on 128 OB/OW children and adolescents (ages: 8-18 years), of whom 52 (40%) with SUA elevation (SUA persantile>75), 76 with (60%) normal SUA level (SUAL). Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2019.2018.0241DOI Listing
February 2019
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Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers.

Clin Pharmacol Drug Dev 2019 Feb 13. Epub 2019 Feb 13.

AstraZeneca, Gaithersburg, MD, USA.

Lesinurad is a selective uric acid reabsorption inhibitor approved for use in combination with xanthine oxidase inhibitors for the treatment of hyperuricemia associated with gout. In vitro, lesinurad was shown to be a weak inhibitor of cytochrome P450 (CYP)2C9 and a weak inducer of CYP3A4. Warfarin is a widely prescribed oral coumarin-based anticoagulant commonly prescribed in gout patients. Read More

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http://dx.doi.org/10.1002/cpdd.662DOI Listing
February 2019
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Perioperative Management of Total Laryngectomy Patients: A Survey of American Head and Neck Society Surgeons.

Ann Otol Rhinol Laryngol 2019 Feb 13:3489419830118. Epub 2019 Feb 13.

2 Department of Otolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine, New York, NY, USA.

Objectives:: Standards of care for total laryngectomy (TL) patients in the postoperative period have not been established. Perioperative care remains highly variable and perhaps primarily anecdotally based. The aim of this study was to survey members of the American Head and Neck Society to capture management practices in the perioperative care of TL patients. Read More

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http://dx.doi.org/10.1177/0003489419830118DOI Listing
February 2019

Evaluation of the efficacy, safety and tolerability of orally administered BI 409306, a novel phosphodiesterase type 9 inhibitor, in two randomised controlled phase II studies in patients with prodromal and mild Alzheimer's disease.

Alzheimers Res Ther 2019 Feb 12;11(1):18. Epub 2019 Feb 12.

Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Centre des Maladies Cognitives et Comportementales, Hôpital La Salpêtrière, Paris, France.

Background: There are currently no approved treatments for the prodromal stage of Alzheimer's disease (AD). Approved symptomatic treatments for mild-to-moderate AD include acetylcholinesterase inhibitors and memantine, but more efficacious treatments are needed. BI 409306 is a potent and selective phosphodiesterase 9 inhibitor assessed for the symptomatic treatment of AD. Read More

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http://dx.doi.org/10.1186/s13195-019-0467-2DOI Listing
February 2019

Simvastatin-loaded solid lipid nanoparticles for enhanced anti-hyperlipidemic activity in hyperlipidemia animal model.

Int J Pharm 2019 Feb 10;560:136-143. Epub 2019 Feb 10.

Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan. Electronic address:

The objective of current study was to develop solid lipid nanoparticles-loaded with simvastatin (SIM-SLNs) and investigate their in vivo anti-hyperlipidemic activity in poloxamer-induced hyperlipidemia model. Nano-template engineering technique was used to prepare SIM-SLNs with palmityl alcohol as lipid core and a mixture of Tween 40/Span 40/Myrj 52 to stabilize the core. The prepared SIM-SLNs were evaluated for physicochemical parameters including particle diameter, surface charge, morphology, incorporation efficiency, thermal behaviour and crystallinity. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.002DOI Listing
February 2019

Quality of INR control and switching to non-Vitamin K oral anticoagulants between women and men with atrial fibrillation treated with Vitamin K Antagonists in Spain. A population-based, real-world study.

PLoS One 2019 12;14(2):e0211681. Epub 2019 Feb 12.

Health Services Research Unit, Foundation for Biomedical Research of Valencia-FISABIO, Valencia, Spain.

Background: Worldwide, there is growing evidence that quality of international normalized ratio (INR) control in atrial fibrillation patients treated with Vitamin K Antagonists (VKA) is suboptimal. However, sex disparities in population-based real-world settings have been scarcely studied, as well as patterns of switching to second-line Non-VKA oral anticoagulants (NOAC). We aimed to assess the quality of INR control in atrial fibrillation patients treated with VKA in the region of Valencia, Spain, for the whole population and differencing by sex, and to identify factors associated with poor control. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211681PLOS
February 2019
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The impact of reducing alcohol consumption in Australia: an estimate of the proportion of potentially avoidable cancers 2013-2037.

Int J Cancer 2019 Feb 12. Epub 2019 Feb 12.

Population Health Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland 4006, Australia.

The International Agency for Research on Cancer first concluded that alcohol causes cancer in humans in 1988. The World Cancer Research Fund has declared that alcohol causes cancer of the oral cavity, pharynx, larynx, oesophagus (squamous cell carcinoma), female breast, colon, rectum, stomach and liver. It recommended that alcohol be avoided altogether to prevent cancer. Read More

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http://dx.doi.org/10.1002/ijc.32204DOI Listing
February 2019
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Rabies control in North America - past, present and future.

Rev Sci Tech 2018 Aug;37(2):421-437

In the first half of the 20th century, rabies in dogs affected Canada, Mexico and the United States of America (USA). However, the role of wildlife in the transmission of the rabies virus was also recognised and outbreaks affecting both wildlife and domestic animals were documented. Canine rabies has since been eliminated from Canada and the USA, and is now only found sporadically in a few southern states of Mexico. Read More

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http://doc.oie.int/dyn/portal/index.seam?page=alo&aloId=
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http://dx.doi.org/10.20506/rst.37.2.2812DOI Listing
August 2018
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Comparison of cheiloscopy, odontometric, and facial index for sex determination in forensic dentistry.

J Forensic Dent Sci 2018 May-Aug;10(2):88-91

Dental Consultant, Vellore, Tamil Nadu, India.

Background: The "gender determination" which is an important human identification procedure not only helps in establishing the biological profile from skeletal and dental remains but also in facial reconstruction of unidentified victims.

Aim: The aim of this study is to analyze predominant types of lip prints (cheiloscopy), accuracy of mandibular canine index (MCI) (odontometric), and facial index in the study population and to identify whether any correlation among the above parameters could help forensic dentistry in solving crimes.

Materials And Methods: A pilot study was conducted in 100 individuals, 50 males and 50 females aged between 20 and 25 years. Read More

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http://dx.doi.org/10.4103/jfo.jfds_102_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344791PMC
February 2019

Challenges to assumptions regarding oral shear rate during oral processing and swallowing based on sensory testing with thickened liquids.

Food Hydrocoll 2018 Nov 23;84:173-180. Epub 2018 May 23.

Department of Food Science, University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada.

For people with dysphagia, or difficulty swallowing, thickened liquids are used to slow bolus flow to make them easier to control. For these liquids, the oral shear rate of 50 s has been adopted as the standard at which viscosity measurements are taken. However, there is evidence to suggest that other shear rates may be more appropriate to model the processes in the mouth and throat. Read More

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http://dx.doi.org/10.1016/j.foodhyd.2018.05.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367734PMC
November 2018

Free flap head and neck reconstruction in the elderly: what is the impact on quality of life?

Acta Otorhinolaryngol Ital 2019 Jan 31. Epub 2019 Jan 31.

Oral and Maxillofacial Surgery, Hospital Maggiore Policlinico of Milano; Milano, Italy.

Morphofunctional reconstruction is a pivotal aspect in the surgery of head and neck neoplasms: nowadays, microvascular free flap surgery represents the gold standard. In choosing the surgical technique, the effects on residual quality of life, especially in elderly people, usually considered more fragile and so often excluded from microsurgical procedures, must be taken into account. This multicentre study evaluated the quality of life index in patients more than 75 years of age and who underwent to head and neck microsurgical reconstruction. Read More

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http://dx.doi.org/10.14639/0392-100X-2149DOI Listing
January 2019
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A Phase I, Multicenter, Dose-Escalation Study of the Oral Selective FGFR inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations.

Clin Cancer Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Medicine, Memorial Sloan Kettering Cancer Center.

Purpose: To investigate tolerability, efficacy, and pharmacokinetics/-dynamics (PK/PD) of Debio 1347, a selective fibroblast growth factor receptor (FGFR) Inhibitor.

Experimental Design: This was a first-in-human, multicenter, open-label study in patients with advanced solid tumors harboring FGFR1-3 gene alterations. Eligible patients received oral Debio 1347 at escalating doses once daily until disease progression or intolerable toxicity. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1959DOI Listing
February 2019
1 Read