19,792 results match your criteria International Journal of Oral & Maxillofacial Implants [Journal]


Vibriocidal Titer and Protection From Cholera in Children.

Open Forum Infect Dis 2019 Apr 11;6(4):ofz057. Epub 2019 Feb 11.

Infectious Diseases Division, Massachusetts General Hospital, Boston.

Background: Vibrio cholerae, the causative agent of cholera, is a major cause of diarrhea worldwide. Children under the age of 5 have the highest disease burden of cholera. Vibriocidal antibody responses following natural infection and oral cholera vaccination (OCV) are associated with protective immunity, but whether this holds uniformly true in young children is not known. Read More

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofz05
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http://dx.doi.org/10.1093/ofid/ofz057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457480PMC
April 2019
1 Read

Budget Impact Model of Omadacycline on Replacing a Proportion of Existing Treatment Options Among Patients Who Present to the Emergency Department with Acute Bacterial Skin and Skin Structure Infections.

Am Health Drug Benefits 2019 Feb;12(1-Supplement 2):S13-S24

Professor, Albany College of Pharmacy and Health Sciences, NY.

Background: Omadacycline is an oral and intravenous (IV) once-daily aminomethylcycline antibiotic that is approved in the United States for the treatment of adults with acute bacterial skin and skin structure infections (ABSSSI). It has broad-spectrum activity against common causative pathogens of ABSSSI, including methicillin-resistant . Omadacycline has been shown to be noninferior to linezolid for the treatment of adults with ABSSSI across 2 phase 3 clinical trials. Read More

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February 2019

Budget Impact of Omadacycline for the Treatment of Patients with Community-Acquired Bacterial Pneumonia in the United States from the Hospital Perspective.

Am Health Drug Benefits 2019 Feb;12(1-Supplement 1):S1-S12

Professor, Albany College of Pharmacy and Health Sciences, NY.

Background: Community-acquired bacterial pneumonia (CABP) is an acute, lower respiratory bacterial infection. Despite advances in medical care, CABP remains associated with considerable morbidity, mortality, and healthcare costs; early empiric treatment is recommended by the Infectious Diseases Society of America and by the American Thoracic Society. Omadacycline is an oral and intravenous (IV) once-daily aminomethylcycline antibiotic that is approved in the United States for the treatment of adult patients with CABP. Read More

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February 2019
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Psychometric validation of Anti-Clot Treatment Scale and Treatment Satisfaction Questionnaire for Medication version II in Japanese patients with atrial fibrillation.

J Med Econ 2019 Apr 17. Epub 2019 Apr 17.

i Modus Outcomes Ltd , Letchworth Garden City , UK.

Aims: The Anti-Clot Treatment Scale (ACTS) and Treatment Satisfaction Questionnaire for Medication version II (TSQM-II) are validated treatment satisfaction patient-reported outcome (PRO) instruments. The ACTS includes two domains: Burdens and Benefits; the TSQM-II includes four: Effectiveness, Side Effects, Convenience, and Global Satisfaction. Japanese-language versions of the ACTS and TSQM-II have been developed and linguistically validated. Read More

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http://dx.doi.org/10.1080/13696998.2019.1609003DOI Listing

[Venous thromboembolic complications in oncological patients: present-day possibilities of effective and safe anticoagulant therapy].

Angiol Sosud Khir 2019 ;25(1):19-23

Department of Surgery, Institute of Additional Professional Education, South Ural State Medical University of the RF Ministry of Public Health, Chelyabinsk, Russia.

Cancer-associated thromboembolic complications in malignant neoplasms are commonly encountered. They deteriorate the course of the underlying disease and are frequent causes of death. The oncological patient is at high risk of not only thrombosis but haemorrhage during anticoagulant therapy. Read More

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http://dx.doi.org/10.33529/angio2019102DOI Listing
January 2019
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Management of adverse events related to endoscopic resection of upper gastrointestinal neoplasms: Review of the literature and recommendations from experts.

Dig Endosc 2019 Apr;31 Suppl 1:4-20

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

Prevention therapy is recommended for lesions >1/2 of the esophageal circumference. Locoregional steroid injection is recommended for lesions >1/2-3/4 of the esophageal circumference and oral steroids are recommended for lesions >1/2 of the subtotal circumference. For lesions of the entire circumference, oral steroid combined with injection steroid is considered. Read More

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http://dx.doi.org/10.1111/den.13388DOI Listing

Endoscopic Submucosal Single- or Multi-tunnel Dissection for Near-Circumferential and Circumferential Superficial Esophageal Neoplastic Lesions.

Gastroenterol Res Pract 2019 12;2019:2943232. Epub 2019 Mar 12.

Department of Gastroenterology and Hepatology, West China Hospital of Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041 Sichuan, China.

This study reports the outcomes of endoscopic submucosal single-tunnel dissection or endoscopic submucosal multi-tunnel dissection for the treatment of esophageal neoplastic lesions of at least three-quarters of the esophageal circumference, including circumferential superficial esophageal neoplastic lesions. From July 2014 to February 2018, a total of 124 lesions underwent endoscopic submucosal tunnel dissection at our hospital. One to four submucosal tunnels were created in the oral to anal direction. Read More

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http://dx.doi.org/10.1155/2019/2943232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434308PMC

Estimation of exposure durations for vitamin D production and sunburn risk in Switzerland.

J Expo Sci Environ Epidemiol 2019 Apr 16. Epub 2019 Apr 16.

Institute for Work and Health, University of Lausanne and Geneva, 1010 Epalignes- Lausanne, Lausanne, Switzerland.

Although overexposure to solar ultraviolet radiation (UVR) is responsible for cutaneous melanoma and epithelial skin cancer and can cause negative health effects such as sunburn, a "little and often" exposure regime is often suggested to produce naturally recommended vitamin D levels, being essential for skeletal health. This study aimed to quantify solar UV doses needed to trigger 1000 International Units (IU) vitamin D doses and, at the same time, producing sunburn in Switzerland. Solar UV erythema irradiance (in mW/m) measured at four meteorological stations in Switzerland for the period 2005-2017 were used to evaluate effective solar UV radiation producing 1000 IU vitamin D doses in skin phototype II and III individuals. Read More

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http://www.nature.com/articles/s41370-019-0137-2
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http://dx.doi.org/10.1038/s41370-019-0137-2DOI Listing
April 2019
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Industry update: the latest developments in the field of therapeutic delivery, 1-31 December 2018.

Authors:
Peter Timmins

Ther Deliv 2019 Apr;10(4):215-226

Department of Pharmacy, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.

1-31 December 2018, the period covered by this article, was again a very interesting period for activity under the therapeutic delivery umbrella, being a particularly solid month for business activity, notably a major acquisition by GSK to expand its oncology portfolio. This was, as it later turns out, the first of several very significant mergers and acquisitions around the turn of the year in the oncology area, more of which will appear in future articles. In that acquisition, the acquisition of Potenza Therapeutics (MA, USA) by Astellas Pharma Inc. Read More

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https://www.future-science.com/doi/10.4155/tde-2019-0003
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http://dx.doi.org/10.4155/tde-2019-0003DOI Listing
April 2019
1 Read

Determinants of infant breastfeeding practices in Nepal: a national study.

Int Breastfeed J 2019 3;14:14. Epub 2019 Apr 3.

3Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.

Background: Optimal breastfeeding practices, reflected by early initiation and feeding of colostrum, avoidance of prelacteal feeds, and continued exclusivity or predominance of breastfeeding, are critical for assuring proper infant nutrition, growth and development.

Methods: We used data from a nationally representative survey in 21 district sites across the Mountains, Hills and Terai (southern plains) of Nepal in 2013. Determinants of early initiation of breastfeeding, feeding of colostrum, prelacteal feeding and predominant breastfeeding were explored in 1015 infants < 12 months of age. Read More

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https://internationalbreastfeedingjournal.biomedcentral.com/
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http://dx.doi.org/10.1186/s13006-019-0208-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448244PMC
April 2019
1 Read

Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry.

J Food Drug Anal 2019 Apr 1;27(2):428-438. Epub 2018 Oct 1.

State Key Laboratory of Chemical Biology and Drug Discovery, Food Safety and Technology Research Centre, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special Administrative Region, Kowloon, China; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), Shenzhen Key Laboratory of Food Biological Safety Control, Shenzhen Research Institute of Hong Kong Polytechnic University, Shenzhen, 518057, China. Electronic address:

Determination of drugs-of-abuse in body fluids of drug abusers is important for the law enforcement as well as the treatment and rehabilitation. In this study, wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS), a simple and cost-effective technique, was developed for rapid detection and quantitation of common drugs-of-abuse, including methamphetamine, methylenedioxymethamphetamine (MDMA), cocaine, heroin and tetrahydrocannabinol (THC), in urine and oral fluid, following our previous successful demonstration for rapid and sensitive detection of ketamine and nor-ketamine in urine and oral fluid by this technique. It was found that the limit-of-detection for methamphetamine could fully fulfill the cut-off value requirements of the international standards, and those of MDMA and cocaine could fulfill some of the requirements. Read More

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http://dx.doi.org/10.1016/j.jfda.2018.09.002DOI Listing

Unlocking the Potential of Saliva-Based Test to Detect HPV-16-Driven Oropharyngeal Cancer.

Cancers (Basel) 2019 Apr 3;11(4). Epub 2019 Apr 3.

The School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology and the Translational Research Institute, Queensland 4059, Australia.

The incidence of human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) is rising in high-income countries, including Australia. Increasing evidence suggests that accurate HPV testing is pivotal for clinical decision making and treatment planning in these patients. Recently, the eighth edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) tumor-node-metastasis (TNM) staging system for OPC (based on the p16INK4a (p16) status) was proposed and has been implemented. Read More

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https://www.mdpi.com/2072-6694/11/4/473
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http://dx.doi.org/10.3390/cancers11040473DOI Listing
April 2019
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Preferred Reporting Items for Animal studies in Endodontics (PRIASE): a development protocol.

Int Endod J 2019 Apr 15. Epub 2019 Apr 15.

School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.

The regulated use of animals in endodontic research is often necessary to investigate the biological mechanisms of endodontic diseases, and to measure the preclinical efficacy, biocompatibility, toxicology, and safety of new treatments, biomaterials, sealers, drugs, disinfectants, irrigants, devices and instruments. Animal testing is most crucial in situations when research on humans is not ethical, practical, or has unknown health risks. Currently there is a wide variability in the quality of manuscripts that report the results of animal studies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/iej.13125
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http://dx.doi.org/10.1111/iej.13125DOI Listing
April 2019
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Proposal for a novel murine model of human periodontitis using and type II collagen antibody injections.

Saudi Dent J 2019 Apr 21;31(2):181-187. Epub 2019 Feb 21.

Department of Pharmacology, New York Medical College, New York, USA.

Introduction: Periodontitis is a chronic disease in humans induced by several pathogens including Although mouse models of human periodontitis have been developed for study using an oral gavage of , existing models take over a month to develop in order to ensure adequate periodontal destruction. The aim of the present study is to determine if using an injection of a cocktail of type II collagen antibodies along with an oral gavage of in mice induces adequate periodontal destruction in a shorter time so as to potentially serve as a more useful mouse model of periodontitis.

Methods: Twenty-eight DBA1/BO male mice were placed in four groups: Group A (antibody injection plus gavage), Group B (gavage only), Group C (antibody injection only), and Group D (neither antibody injection nor gavage, control). Read More

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http://dx.doi.org/10.1016/j.sdentj.2019.02.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445525PMC

Pursuing use of optimal formulations for paediatric HIV epidemic control - a look at the use of LPV/r oral pellets and oral granules.

J Int AIDS Soc 2019 Apr;22(4):e25267

United States Agency for International Development, Washington, DC, USA.

Introduction: Despite a significant reduction in mother-to-child transmission of HIV, an estimated 180,000 children were infected with HIV in 2017, and only 52% of children under 15 years of age living with HIV (CLHIV) are on life-saving antiretroviral therapy (ART). Without effective treatment, half of CLHIV die before the age of two years and only one in five survives to five years of age.

Discussion: Over the past four years, the United States Food and Drug Administration tentatively approved new formulations of lopinavir/ritonavir (LPV/r) in the form of oral pellets and oral granules. Read More

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http://dx.doi.org/10.1002/jia2.25267DOI Listing

The clinical course and potential underlying mechanisms of everolimus-induced hyperglycemia.

Endocr J 2019 Apr 13. Epub 2019 Apr 13.

Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Ishikawa 920-8640, Japan.

The mechanistic target of rapamycin (mTOR) inhibitor everolimus is an antitumor agent known to cause hyperglycemia. However, the clinical course of everolimus-induced hyperglycemia, its pathophysiological basis, and the treatment strategy are not clear. In this case series report, we present the clinical course of everolimus-induced hyperglycemia in four patients. Read More

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https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub
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http://dx.doi.org/10.1507/endocrj.EJ18-0542DOI Listing
April 2019
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Hepatitis C virus infection in children and adolescents.

Lancet Gastroenterol Hepatol 2019 Apr 10. Epub 2019 Apr 10.

Global Hepatitis Programme and HIV Department, World Health Organization, Geneva, Switzerland.

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and associated morbidity and mortality worldwide. Short-course, oral, curative, direct-acting antiviral regimens have transformed treatment for HCV infection. Since the 2016 launch of the first global strategy towards elimination of viral hepatitis as a public health threat by 2030, the predominant focus of the global response has been on the treatment of adults, who bear the greatest burden of morbidity and mortality of HCV-related chronic liver disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24681253193004
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http://dx.doi.org/10.1016/S2468-1253(19)30046-9DOI Listing
April 2019
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Protective Actions of Oral Administration of Bifidobacterium longum CBi0703 in Spontaneous Osteoarthritis in Dunkin Hartley Guinea Pig Model.

Cartilage 2019 Apr 13:1947603519841674. Epub 2019 Apr 13.

5 Biose®, R&D Department, Arpajon-sur-Cère, France.

Objective: The aim of this study was to evaluate the effects of a lyophilized inactivated culture (LIC) from Bifidobacterium longum CBi0703 in a spontaneous model of osteoarthritis (OA) in Dunkin Hartley guinea pigs. Histology of cartilage and synovial membrane was the primary outcome. Biomarkers were also considered to evaluate the treatment efficacy. Read More

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http://journals.sagepub.com/doi/10.1177/1947603519841674
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http://dx.doi.org/10.1177/1947603519841674DOI Listing
April 2019
1 Read

[Gestational diabetes mellitus (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Abteilung für Innere Medizin, Privatklinik Wehrle-Diakonissen, Salzburg, Österreich.

Gestational diabetes mellitus (GDM) is defined as a glucose tolerance disorder with onset during pregnancy and is associated with increased feto-maternal morbidity as well as long-term complications in mother and child. Women who fulfil the criteria of a manifest diabetes in early pregnancy (fasting plasma glucose >126 mg/dl, spontaneous glucose level >200 mg/dl or HbA1c > 6.5% before 20 weeks of gestation) should be classified as having manifest diabetes in pregnancy and treated as such. Read More

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http://dx.doi.org/10.1007/s00508-018-1419-8DOI Listing

Using Mendelian randomisation to assess causality in observational studies.

Evid Based Ment Health 2019 Apr 12. Epub 2019 Apr 12.

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

Objective: Mendelian randomisation (MR) is a technique that aims to assess causal effects of exposures on disease outcomes. The paper aims to present the main assumptions that underlie MR, the statistical methods used to estimate causal effects and how to account for potential violations of the key assumptions.

Methods: We discuss the key assumptions that should be satisfied in an MR setting. Read More

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http://dx.doi.org/10.1136/ebmental-2019-300085DOI Listing

Cross-Country Validation of the Association Between Oral Health and General Health in Community-Dwelling Older Adults.

J Am Med Dir Assoc 2019 Apr 9. Epub 2019 Apr 9.

KU Leuven LUCAS, Centre for Care Research and Consultancy, Leuven, Belgium.

Objective: Oral health is known to be associated with general health, but longitudinal relationships between oral health and general health indicators have not yet been fully explored in international research.

Setting And Participants: The sample consisted of 3 longitudinal databases: a sample from Belgium from the Protocol 3 project (n = 8359), a combined sample from 6 European countries (n = 2501) from the IBenC study (Belgium, Finland, Iceland, Germany, Italy, and the Netherlands), and a sample from New Zealand (n = 15,012). All clients were 65 years or older and received long-term home care services. Read More

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http://dx.doi.org/10.1016/j.jamda.2019.02.020DOI Listing

In Vitro and In Vivo Studies of Hydrophilic Electrospun PLA95/β-TCP Membranes for Guided Tissue Regeneration (GTR) Applications.

Nanomaterials (Basel) 2019 Apr 11;9(4). Epub 2019 Apr 11.

Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.

The guided tissue regeneration (GTR) membrane is a barrier intended to maintain a space for alveolar bone and periodontal ligament tissue regeneration but prevent the migration of fast-growing soft tissue into the defect sites. This study evaluated the physical properties, in vivo animal study, and clinical efficacy of hydrophilic PLA95/β-TCP GTR membranes prepared by electrospinning (ES). The morphology and cytotoxicity of ES PLA95/β-TCP membranes were evaluated by SEM and 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) respectively. Read More

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http://dx.doi.org/10.3390/nano9040599DOI Listing

Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation.

PLoS Biol 2019 Apr 12;17(4):e2006506. Epub 2019 Apr 12.

Unit of Computational Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage-specific genes but also the coordinated adaptation of housekeeping functions from a metabolically active, proliferative state toward quiescence. How metabolic and cell-cycle states are coordinated with the regulation of cell type-specific genes is an important question, because dissociation between differentiation, cell cycle, and metabolic states is a hallmark of cancer. Here, we use a model system to systematically identify key transcriptional regulators of Ikaros-dependent B cell-progenitor differentiation. Read More

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http://dx.doi.org/10.1371/journal.pbio.2006506DOI Listing
April 2019
4 Reads

An ethnobotanical survey of medicinal plants used for diabetes treatment in Rabat, Morocco.

Heliyon 2019 Mar 27;5(3):e01421. Epub 2019 Mar 27.

Microbiology and Molecular Biology Team, Center of Plant and Microbial Biotechnology, Biodiversity and Environment, Faculty of Sciences, MOHAMMED V UNIVERSITY IN RABAT, 4 Avenue Ibn Battouta PB 1014, Rabat, Morocco.

Diabetes mellitus is a major public health problem in Morocco. The value of ethnobotanical information is now increasingly acknowledged. To inventory and to provide ethnobotanical information on some of the medicinal plants used in traditional medicine to treat diabetes in Rabat (Morocco), a survey was undertaken from March 1 to April 30 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058440183569
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http://dx.doi.org/10.1016/j.heliyon.2019.e01421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441794PMC
March 2019
2 Reads

Prevalence of food allergy among schoolchildren in Kuwait and its association with the coexistence and severity of asthma, rhinitis, and eczema: A cross-sectional study.

Authors:
Ali H Ziyab

World Allergy Organ J 2019 30;12(4):100024. Epub 2019 Mar 30.

Department of Community Medicine and Behavioral Sciences, Faculty of Medicine, Kuwait University, Safat, Kuwait.

Background: Food allergy (FA) is a common public health problem that affects both children and adults. Empirical knowledge of the burden of FA in Kuwait is limited. This study sought to estimate the prevalence of FA among schoolchildren in Kuwait and assess associations between FA and the coexistence and severity of asthma, rhinitis, and eczema. Read More

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http://dx.doi.org/10.1016/j.waojou.2019.100024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441753PMC
March 2019
1 Read

Salivary gland carcinoma in Shanghai (2003-2012): an epidemiological study of incidence, site and pathology.

BMC Cancer 2019 Apr 11;19(1):350. Epub 2019 Apr 11.

Department of Oral & Maxillofacial - Head & Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.

Background: Salivary gland carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias in incidence evaluation. Most population-based cancer registries have grouped cancers of the minor salivary glands with oral cancer instead of with salivary gland carcinoma as a whole, because of the international disease coding. Read More

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http://dx.doi.org/10.1186/s12885-019-5564-xDOI Listing

Home visits by occupational therapists in acute hospital care: a systematic review.

Int J Rehabil Res 2019 Apr 9. Epub 2019 Apr 9.

Department of Rehabilitation Medicine, Teikyo University School of Medicine University Hospital, Mizonokuchi, Japan.

The aim of this review was to determine the utility of home visits by occupational therapists before and after a patient is discharged from an acute care hospital. All relevant published studies were identified by searching the CENTRAL, MEDLINE, EMBASE, Occupational Therapy Systematic Evaluation of Evidence, and WHO International Clinical Trials Registry Platform databases. Randomized controlled trials were included regardless of sex, age, disease, and duration of acute hospitalization. Read More

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http://dx.doi.org/10.1097/MRR.0000000000000350DOI Listing

Differential clinical significance of COL5A1 and COL5A2 in tongue squamous cell carcinoma.

J Oral Pathol Med 2019 Apr 10. Epub 2019 Apr 10.

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Background: Type V collagen (COL5), in the functional heterotrimer [α1(V) α2(V)] isoform, participates in the malignancies of various cancers. However, its role in tongue squamous cell carcinoma (TSCC) remains unclear.

Materials And Methods: The expression levels of COL5A1 and COL5A2 polypeptide chains were examined using the tissue microarray from 245 TSCC patients with immunohistochemistry. Read More

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http://dx.doi.org/10.1111/jop.12861DOI Listing

[My road to malaria control: an interview with Li Guoqiao].

Authors:
X H Zhang

Zhonghua Yi Shi Za Zhi 2019 Jan;49(1):38-48

Guangzhou University of Chinese Medicine, Guangzhou 510000, China.

In order to prevent and treat drug-resistant falciparum malaria, China began the task named "534" in 1967.Guangzhou University of Chinese Medicine participated in this task, Li Guoqiao was one of the leaders.He and his team were sent to Hainan and Yunnan to prevent and cure falciparum malaria. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0255-7053.2019.01.008DOI Listing
January 2019
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Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice.

Cell Rep 2019 Apr;27(2):561-571.e6

Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aoba-cho, Higashimurayama-shi, Tokyo 189-0002, Japan.

Severe invasive group A Streptococcus (GAS) infection evades anti-bacterial immunity by attenuating the cellular components of innate immune responses. However, this loss of protection is compensated for by interferon (IFN)-γ-producing immature myeloid cells (γIMCs), which are selectively recruited upon severe invasive GAS infection in mice. Here, we demonstrate that γIMCs provide this IFN-γ-mediated protection by sequentially sensing GAS through two distinct pattern recognition receptors. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.056DOI Listing
April 2019
2 Reads

Top-100 Most Cited Dental Articles with Authors from Brazil.

Braz Dent J 2019 Mar-Apr;30(2):96-105. Epub 2019 Apr 4.

Graduate Program in Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil.

This study analyzes the characteristics of the top-100 most cited articles published in international dental journals with at least one coauthor affiliated to Brazil. A search in Scopus database for articles published between 1996 and 2017 was carried out in the 178 journals belonging to the category "Dentistry" identified in SCImago Journals & Country Rank. From the top-100 most cited articles, variables related to the journal, article, and authors were collected. Read More

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http://dx.doi.org/10.1590/0103-6440201902529DOI Listing

Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal diseases and dental caries.

Cochrane Database Syst Rev 2019 Apr 10;4:CD012018. Epub 2019 Apr 10.

Cochrane Oral Health, Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Coupland Building 3, Oxford Road, Manchester, UK, M13 9PL.

Background: Dental caries (tooth decay) and periodontal diseases (gingivitis and periodontitis) affect the majority of people worldwide, and treatment costs place a significant burden on health services. Decay and gum disease can cause pain, eating and speaking difficulties, low self-esteem, and even tooth loss and the need for surgery. As dental plaque is the primary cause, self-administered daily mechanical disruption and removal of plaque is important for oral health. Read More

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http://dx.doi.org/10.1002/14651858.CD012018.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457073PMC
April 2019
1 Read

The influence of birth cohort and calendar period on global trends in ovarian cancer incidence.

Int J Cancer 2019 Apr 10. Epub 2019 Apr 10.

Section of Cancer Surveillance, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, France.

Ovarian cancer is the eighth most common cancer in women worldwide and incidence rates vary markedly by world region. This study provides a comprehensive overview of ovarian cancer incidence trends globally, examining the influence of birth cohort and period of diagnosis on changing risk. We presented current patterns and trends of ovarian cancer incidence until 2012 using data from successive volumes of Cancer Incidence in Five Contents. Read More

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http://dx.doi.org/10.1002/ijc.32322DOI Listing
April 2019
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Unmasking herd protection by an oral cholera vaccine in a cluster-randomized trial.

Int J Epidemiol 2019 Apr 9. Epub 2019 Apr 9.

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Background: Several studies have shown that inactivated, whole-cell oral cholera vaccines (OCVs) confer both direct protection on vaccinees and herd protection on populations. Because our earlier cluster-randomized effectiveness trial (CRT) in urban Bangladesh failed to detect OCV herd protection, we reanalysed the trial to assess whether herd effects were masked in our original analysis.

Methods: A total of 267 270 persons were randomized to 90 approximately equal-sized clusters. Read More

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http://dx.doi.org/10.1093/ije/dyz060DOI Listing

Characteristics of software used in self-management of vitamin K antagonist therapy: A systematic review.

Eur J Cardiovasc Nurs 2019 Apr 10:1474515119843739. Epub 2019 Apr 10.

3 Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction And Goal: Currently, 1-2% of the population in developed countries are under treatment with oral anticoagulants. An appropriate strategy to deal with this increase in demand of treatment with oral anticoagulants and to manage the costs is the transfer of part or all of the responsibility for managing treatment to the patients. The use of information technology, particularly electronic health software, can be an appropriate method to improve the quality of self-management of treatment with these drugs. Read More

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http://dx.doi.org/10.1177/1474515119843739DOI Listing
April 2019
2 Reads
1.828 Impact Factor

Ejaculation Sparing Bladder Neck Incision with Holmium Laser in Patients with Urinary Symptoms and Small Prostates: Short-Term Functional Results.

Urol Int 2019 Apr 9:1-6. Epub 2019 Apr 9.

Department of Robotic Urological Surgery, Abano Terme Hospital, Abano Terme, Italy.

Background: The treatment options for male lower urinary tract symptoms (LUTS) widely range from self-monitoring to oral medications to surgical procedures. As far as concerns surgical treatment of obstructive LUTS, transurethral incision of the prostate is considered as the gold standard in patients with mild benign prostatic enlargement.

Objectives: The aim of our study is to describe this novel approach to perform ejaculation sparing Holmium laser bladder neck incision (ES-HoBNI), with particular regard to its effect on ejaculation and LUTS relief. Read More

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http://dx.doi.org/10.1159/000499410DOI Listing

Treatment stratification of respiratory syncytial virus infection in allogeneic stem cell transplantation.

J Infect 2019 Apr 6. Epub 2019 Apr 6.

Department of Clinical Haematology, Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK.

Background: Due to paucity of evidence to guide management of allogeneic haematopoietic stem cell transplantation (allo-HSCT) patients with respiratory syncytial virus (RSV) infections national and international guidelines make disparate recommendations.

Methods: The outcomes of allo-HSCT recipients with RSV infection between 2015 and 2017 were assessed using the following treatment stratification; upper respiratory tract infections (URTI) being actively monitored and lower respiratory tract infections (LRTI) treated with short courses of oral ribavirin combined with intravenous immunoglobulin (IVIG, 2 g/kg).

Results: During the study period 49 RSV episodes were diagnosed (47% URTI and 53% LRTI). Read More

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http://dx.doi.org/10.1016/j.jinf.2019.04.004DOI Listing
April 2019
2 Reads

Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers: The AMATERASU Randomized Clinical Trial.

JAMA 2019 04;321(14):1361-1369

Department of Surgery, International University of Health and Welfare Hospital, Tochigi, Japan.

Importance: Randomized clinical trials of vitamin D supplementation for secondary prevention in patients with cancer are needed, given positive results of observational studies.

Objective: To determine whether postoperative vitamin D3 supplementation can improve survival of patients with digestive tract cancers overall and in subgroups stratified by 25-hydroxyvitamin D (25[OH]D) levels.

Design, Setting, And Participants: The AMATERASU trial, a randomized, double-blind, placebo-controlled trial conducted at a single university hospital in Japan. Read More

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http://dx.doi.org/10.1001/jama.2019.2210DOI Listing
April 2019
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Effects of body mass index on the safety and effectiveness of direct oral anticoagulants: a retrospective review.

J Thromb Thrombolysis 2019 Apr 8. Epub 2019 Apr 8.

Department of Cardiology, Parkview Health, 11109 Parkview Plaza Drive, Fort Wayne, IN, 46845, USA.

Background: The International Society on Thrombosis and Haemostasis recommends avoiding the use of direct oral anticoagulants (DOACs) in patients with a body mass index (BMI) greater than 40 kg/m or weight greater than 120 kg.

Hypothesis: Higher BMI is associated with altered pharmacokinetics which may affect the safety and effectiveness for DOACs.

Methods: Data were collected on 3458 patients taking a DOAC prior to admission to a Midwestern health system between February 2013 and August 2016. Read More

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http://dx.doi.org/10.1007/s11239-019-01857-2DOI Listing

Impact of a variable number tandem repeat in the CYP2C9 promoter on warfarin sensitivity and responsiveness in Jordanians with cardiovascular disease.

Pharmgenomics Pers Med 2019 21;12:15-22. Epub 2019 Mar 21.

Department of Applied Biological Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan,

Purpose: The purpose of this study was to investigate the influence of CYP/CYP450 2C9 () promoter variable number tandem repeat (p-VNTR) polymorphism on susceptibility to cardiovascular disease and on warfarin sensitivity and responsiveness, in Jordanians with cardiovascular disease during initiation and stabilization phases of therapy.

Patients And Methods: A total of 211 cardiovascular patients who were being treated with warfarin anticoagulants and 205 healthy individuals were enrolled in this study. PCR-based methods were performed to analyze the effects of p-VNTR polymorphism on warfarin metabolism. Read More

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http://dx.doi.org/10.2147/PGPM.S189838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432888PMC

Daptomycin Dose-Ranging Evaluation with Single vs. Multi-Dose Ceftriaxone Combinations against in an Simulated Endocarditis Vegetation Model.

Antimicrob Agents Chemother 2019 Apr 8. Epub 2019 Apr 8.

Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI

The viridans group streptococci (VGS) are a heterogeneous group of organisms which are important components of the normal human oral flora. Among the VGS, the subgroup is one of the most common causes of infective endocarditis (IE). Daptomycin (DAP) is a potential alternative therapeutic option for invasive infections, given high rates of β-lactam resistance and vancomycin tolerance in such strains. Read More

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http://dx.doi.org/10.1128/AAC.00386-19DOI Listing
April 2019
4 Reads

Educational Models for the Re-Establishment of Dental Therapy Education in Canada.

J Dent Educ 2019 Apr 8. Epub 2019 Apr 8.

Susanne Sunell, EdD, is Educational Consultant and Researcher, Omni Educational Group Ltd., Vancouver, Canada; Ann E. Wright, RDH, MBA, is Practice Consultant, ROI Corporation, Mississauga, Canada; Brenda K. Udahl, RDH, MHRD, was Academic Chair of Dental Programs, Saskatchewan Polytechnic, Regina, Canada, at the time of this study; and Paula Benbow, RDH, MPH, was Manager of Health Policy, Canadian Dental Hygienists Association, Ottawa, Canada, at the time of this study.

With the closure of the Canadian dental therapy program in Saskatchewan in 2011 and the increasing need for oral health providers, there have been growing discussions at the national and provincial levels regarding the re-establishment of a provider with dental therapy abilities. The aims of this study were to define models for dental therapy education in Canada and explore how dental therapy abilities could best be integrated into Canadian post-secondary education. In 2017, purposeful sampling was used to invite key informants to participate in a semi-structured interview. Read More

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http://dx.doi.org/10.21815/JDE.019.085DOI Listing
April 2019
3 Reads

Time in therapeutic range and risk of thromboembolism and bleeding in patients with a mechanical heart valve prosthesis.

J Thorac Cardiovasc Surg 2019 Feb 27. Epub 2019 Feb 27.

Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Objective: Oral anticoagulation with vitamin K antagonists is recommended after mechanical heart valve replacement. However, data regarding the association between the quality of vitamin K antagonist treatment and the risk of complications are sparse.

Methods: Patients undergoing mechanical heart valve replacement (1997-2012) with available data on international normalized ratio values were identified in Danish registries. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.02.061DOI Listing
February 2019
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Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study.

BMC Med 2019 Apr 8;17(1):76. Epub 2019 Apr 8.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool and The Royal Liverpool and Broadgreen University Hospitals NHS Trust, members of Liverpool Health Partners, Liverpool, UK.

Background: Warfarin is a widely used oral anticoagulant. Determining the correct dose required to maintain the international normalised ratio (INR) within a therapeutic range can be challenging. In a previous trial, we showed that a dosing algorithm incorporating point-of-care genotyping information ('POCT-GGD' approach) led to improved anticoagulation control. Read More

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http://dx.doi.org/10.1186/s12916-019-1308-7DOI Listing

Association between Polymorphisms of and Metabolic Response to Metformin in Women with Polycystic Ovary Syndrome.

Int J Mol Sci 2019 Apr 7;20(7). Epub 2019 Apr 7.

Department of Obstetrics and Gynecology, College of Medicine and Hospital, National Cheng Kung University, Tainan 704, Taiwan.

Insulin-sensitizer treatment with metformin is widely used in polycystic ovary syndrome (PCOS). However, the treatment effectiveness shows individual differences in PCOS patients. Organic cation transporter (OCT) 1 and 2 have been reported to mediate metformin transport in the liver and kidney, respectively. Read More

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http://dx.doi.org/10.3390/ijms20071720DOI Listing
April 2019
7 Reads

Clinical manifestations, immunological features and prognosis of Chinese pediatric systemic lupus erythematosus: A single-center study.

Int J Rheum Dis 2019 Apr 8. Epub 2019 Apr 8.

Department of Nephrology and Rheumatology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Aim: Since there are only a few reports on pediatric systemic lupus erythematosus (pSLE) in Chinese populations, therefore we retrospectively report the clinical and immunological features as well as renal outcome in Chinese pSLE.

Methods: Patients diagnosed with pSLE at Shanghai Children's Medical Center between 2001 and 2016 were evaluated and clinical data were retrospectively collected.

Results: A total of 102 pSLE patients were analyzed. Read More

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http://dx.doi.org/10.1111/1756-185X.13547DOI Listing
April 2019
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Implementation of a comprehensive safer conception intervention for HIV-serodiscordant couples in Kenya: uptake, use and effectiveness.

J Int AIDS Soc 2019 Apr;22(4):e25261

Department of Global Health, University of Washington, Seattle, WA, USA.

Introduction: Safer conception strategies minimize HIV risk during condomless sex to become pregnant. Gaps remain in understanding the acceptability, feasibility and choices HIV-serodiscordant couples make when multiple safer conception options are available.

Methods: We conducted a pilot study of a comprehensive safer conception package for HIV-serodiscordant couples with immediate fertility desires in Kenya from March 2016 to April 2018. Read More

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http://dx.doi.org/10.1002/jia2.25261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452026PMC

Study of oral potentially malignant disorders related to various risk factors amongst the patients attending hospitals in Bhopal, India.

Med Pharm Rep 2019 Jan 15;92(1):66-71. Epub 2019 Jan 15.

Department of Oral Medicine and Radiology, College of Dental Sciences and Hospital, Amargadh, District - BhavnagarGujarat, India.

Background And Aims: Oral potentially malignant disorders constitute one of the major oral health problems in India. Few studies have been undertaken on potentially malignant disorders in central India, specifically in Bhopal. Hence the present study was conducted to assess the oral potentially malignant disorders in the patients attending hospitals of Bhopal, India. Read More

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http://dx.doi.org/10.15386/cjmed-906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448500PMC
January 2019

Comparative ultrastructural observations of the Egyptian schistosomes: and .

J Parasit Dis 2019 Mar 14;43(1):120-133. Epub 2018 Dec 14.

1Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt.

An ultrastructural topography has been made to the tegumental architectures of two Egyptian schistosomes namely and hosted in a model animal namely The distribution of sensory papillae on the oral sucker were arranged in one circle around the rim in addition to some papillae in upper part of inner zone in male, female and in male The differences in the types of papillae, their distribution and shape of ridges on various parts of the body surface which are quite specific for each species was studied. Also, the ventral tegument of female's displays larger and more numerous sensory papillae. Both ciliated and non-ciliated papillae were observed in this work which makes a link with another species of schistosome . Read More

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http://dx.doi.org/10.1007/s12639-018-1067-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423204PMC