10,358 results match your criteria International Journal of Oncology [Journal]


Bile acids promote gastric intestinal metaplasia by upregulating CDX2 and MUC2 expression via the FXR/NF-κB signalling pathway.

Int J Oncol 2019 Jan 22. Epub 2019 Jan 22.

Department of General Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

Bile acids serve a critical role in the induction of gastric intestinal metaplasia (IM) and gastric carcinogenesis. The present study investigated the effects of bile acids on the induction of gastric IM formation. The results demonstrated that the expression levels of caudal‑related homeobox transcription factor 2 (CDX2), mucin 2 (MUC2) and farnesoid X receptor (FXR) were increased in vitro and in vivo following treatment with bile acids, and CDX2 transcriptionally activated MUC2 expression. Read More

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http://dx.doi.org/10.3892/ijo.2019.4692DOI Listing
January 2019

Sorafenib/MEK inhibitor combination inhibits tumor growth and the Wnt/β‑catenin pathway in xenograft models of hepatocellular carcinoma.

Int J Oncol 2019 Jan 23. Epub 2019 Jan 23.

R&D Pharmaceuticals, Bayer AG, D‑13353 Berlin, Germany.

Mutations affecting the Wnt/β‑catenin pathway have been identified in 26‑40% of hepatocellular carcinoma (HCC) cases. Aberrant activation of this pathway leads to uncontrolled cell proliferation and survival. Thus, identifying Wnt/β‑catenin pathway inhibitors may benefit a subset of patients with HCC. Read More

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http://dx.doi.org/10.3892/ijo.2019.4693DOI Listing
January 2019
1 Read

lncRNA H19 promotes viability and epithelial-mesenchymal transition of lung adenocarcinoma cells by targeting miR-29b-3p and modifying STAT3.

Int J Oncol 2019 Jan 24. Epub 2019 Jan 24.

Department of Respiration, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China.

Considering the joint contribution of long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs/miRs) to tumorigenesis, the aim of the present study was to investigate whether and how lncRNA H19 targets miR‑29b‑3p to affect the progression of lung adenocarcinoma by the modulation of signal transducer and activator of transcription 3 (STAT3). A total of 305 lung adenocarcinoma tissues and four human lung adenocarcinoma cell lines (i.e. Read More

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http://dx.doi.org/10.3892/ijo.2019.4695DOI Listing
January 2019
1 Read

MACC1 overexpression in carcinoma‑associated fibroblasts induces the invasion of lung adenocarcinoma cells via paracrine signaling.

Int J Oncol 2019 Jan 30. Epub 2019 Jan 30.

Department of Thoracic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China.

Carcinoma‑associated fibroblasts (CAFs) are essential for initiating lung cancer cell invasion and metastasis. An elevated MACC1 expression has been implicated in the progression of lung adenocarcinoma. Hitherto, the role of MACC1 in lung adenocarcinoma‑derived CAFs remains unclear. Read More

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http://dx.doi.org/10.3892/ijo.2019.4702DOI Listing
January 2019

Long non-coding RNA TUG1 recruits miR‑29c‑3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells.

Int J Oncol 2019 Jan 28. Epub 2019 Jan 28.

Department of Dermatology, Henan Traditional Chinese Medicine Hospital, Zhengzhou, Henan 450002, P.R. China.

Melanoma is an aggressive type of skin cancer, characterized by high mortality rates worldwide. Therefore, the identification of new diagnostic markers and therapeutic targets for melanoma is imperative. Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) play important roles in tumor initiation and progression. Read More

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http://dx.doi.org/10.3892/ijo.2019.4699DOI Listing
January 2019

A novel mechanism for the anticancer activity of aspirin and salicylates.

Int J Oncol 2019 Jan 29. Epub 2019 Jan 29.

Department of Biomedical Science and Physiology, School of Sciences, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK.

Epidemiological studies indicate that long‑term aspirin usage reduces the incidence of colorectal cancer (CRC) and may protect against other non‑CRC associated adenocarcinomas, including oesophageal cancer. A number of hypotheses have been proposed with respect to the molecular action of aspirin and other non‑steroidal anti‑inflammatory drugs in cancer development. The mechanism by which aspirin exhibits toxicity to CRC has been previously investigated by synthesising novel analogues and derivatives of aspirin in an effort to identify functionally significant moieties. Read More

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http://dx.doi.org/10.3892/ijo.2019.4701DOI Listing
January 2019
5 Reads

Triacetyl resveratrol upregulates miRNA‑200 and suppresses the Shh pathway in pancreatic cancer: A potential therapeutic agent.

Int J Oncol 2019 Jan 28. Epub 2019 Jan 28.

Kansas City VA Medical Center, Kansas City, MO 66128, USA.

Trans‑3,4',5‑trihydroxystilbene (resveratrol) is a naturally occurring polyphenolic phytoalexin with marked anticancer activities, and is mainly found in grapes, berries and peanuts. However, due to a low bioavailability, it has not progressed to clinical practice for cancer treatment. Therefore, the aims of the present study were to examine the anticancer activities of the resveratrol derivative, triacetyl resveratrol (TCRV), in pancreatic cancer cells. Read More

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http://dx.doi.org/10.3892/ijo.2019.4700DOI Listing
January 2019

Upregulation of microRNA‑194‑5p inhibits hypopharyngeal carcinoma cell proliferation, migration and invasion by targeting SMURF1 via the mTOR signaling pathway.

Int J Oncol 2019 Feb 4. Epub 2019 Feb 4.

Department of Ear, Nose and Throat, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

Hypopharyngeal carcinoma (HPC) is an aggressive malignancy with the worst prognosis among all head and neck cancers. MicroRNAs (miRNAs) are involved in the development of many human cancers, and may function as oncogenes or tumor suppressors. The present study aimed to evaluate the effects of miRNA (miR)‑194‑5p on the proliferation and invasion of HPC cells and to identify the potential regulatory mechanism. Read More

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http://dx.doi.org/10.3892/ijo.2019.4711DOI Listing
February 2019
1 Read

Efficacy of aflibercept with FOLFOX and maintenance with fluoropyrimidine as first‑line therapy for metastatic colorectal cancer: GERCOR VELVET phase II study.

Int J Oncol 2019 Feb 1. Epub 2019 Feb 1.

Department of Medical Oncology, Franco‑British Institute, 92300 Levallois‑Perret, France.

Aflibercept in combination with 5‑fluorouracil (5‑FU)/irinotecan improves overall survival in the second‑line therapy of patients with metastatic colorectal cancer (mCRC). In this study, we evaluated the effects of aflibercept in first‑line therapy with FOLFOX followed by maintenance with fluoropyrimidine. VELVET was a prospective, single‑arm multicenter phase II study (completed). Read More

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http://dx.doi.org/10.3892/ijo.2019.4709DOI Listing
February 2019
1 Read

Downregulation of protein disulfide‑isomerase A3 expression inhibits cell proliferation and induces apoptosis through STAT3 signaling in hepatocellular carcinoma.

Int J Oncol 2019 Feb 4. Epub 2019 Feb 4.

Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo 113‑8602, Japan.

Protein disulfide‑isomerase A3 (PDIA3) is a chaperone protein that modulates folding of newly synthesized glycoproteins and responds to endoplasmic reticulum (ER) stress. Previous studies reported that increased expression of PDIA3 in hepatocellular carcinoma (HCC) is a marker for poor prognosis. However, the mechanism remains poorly understood. Read More

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http://dx.doi.org/10.3892/ijo.2019.4710DOI Listing
February 2019

Lysyl oxidase assists tumor‑initiating cells to enhance angiogenesis in hepatocellular carcinoma.

Int J Oncol 2019 Jan 31. Epub 2019 Jan 31.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cell Biology, Peking University Cancer Hospital and Institute, Beijing 100142, P.R. China.

A highly tumorigenic and malignant sub‑population of HCC containing tumor‑initiating cells (TICs) are defined by high self‑renewal and sphere formation ability. Lysyl oxidase (LOX) regulates various factors involved in extracellular matrix (ECM) maintenance, migration and angiogenesis. Certain reports have demonstrated the role of LOX in ECM crosslinking, however, the cancer‑promoting effects of LOX in HCC remain unclear, and whether LOX has a role in the regulation of angiogenesis in HCC TICs has not been elucidated. Read More

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http://dx.doi.org/10.3892/ijo.2019.4705DOI Listing
January 2019

Glyceryl trinitrate‑induced cytotoxicity of docetaxel‑resistant prostatic cancer cells is associated with differential regulation of clusterin.

Int J Oncol 2019 Feb 1. Epub 2019 Feb 1.

Laboratoire d'Immunologie et Immunothérapie des Cancers, EPHE, PSL Research University, F‑75000 Paris, France.

Metastatic castration resistant prostate cancer (mCRPC) relapse due to acquired resistance to chemotherapy, such as docetaxel, remains a major threat to patient survival. Resistance of mCRPC to docetaxel can be associated with elevated levels of soluble clusterin (sCLU) and growth differentiation factor‑15 (GDF‑15). Any strategies aiming to modulate sCLU and/or GDF‑15 in docetaxel‑resistant prostate cancer cells present a therapeutic interest. Read More

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http://dx.doi.org/10.3892/ijo.2019.4708DOI Listing
February 2019

lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma.

Int J Oncol 2019 Feb 1. Epub 2019 Feb 1.

Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.

As a new group of important effector molecules involved in multiple cancer types, including breast cancer, lung cancer and oral squamous cell carcinoma, long noncoding RNAs (lncRNAs) have attracted considerable attention recently. However, the underlying cause that induces the dysregulated lncRNAs in cancer remains poorly understood. In the present study, the regulatory model of the lncRNA placenta‑specific protein 2 (PLAC2) upregulation in oral squamous cell carcinoma (OSCC) was investigated and its biological functions in OSCC malignant progression was identified. Read More

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http://dx.doi.org/10.3892/ijo.2019.4707DOI Listing
February 2019

2,3,7,8‑tetrachlorodibenzo‑p‑dioxin suppresses the growth of human colorectal cancer cells in vitro: Implication of the aryl hydrocarbon receptor signaling.

Int J Oncol 2019 Jan 30. Epub 2019 Jan 30.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), 700 Tiverton Avenue, Los Angeles, CA 90095‑1732, USA.

Human colorectal cancer is the third most common cancer disease with a 5‑year survival rate of 55% in USA in 2016. The investigation to identify novel biomarker factors with molecular classification may provide notable clinical information to prolong the survival of patients with colorectal cancer. The aryl hydrocarbon receptor (AHR) binds the AHR nuclear translocator in the cytoplasm of various types of cells, including liver cells, and then binds to the xenobiotic responsive element on various genes. Read More

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http://dx.doi.org/10.3892/ijo.2019.4703DOI Listing
January 2019

The proteasome inhibitor, bortezomib, induces prostate cancer cell death by suppressing the expression of prostate-specific membrane antigen, as well as androgen receptor.

Authors:
Kenji Kuroda He Liu

Int J Oncol 2019 Feb 1. Epub 2019 Feb 1.

Laboratory of Urological Oncology, Department of Urology, Weill Cornell Medical College, New York, NY 10065, USA.

The progression of primary prostate cancer (PC) is dependent on the androgen receptor (AR) and prostate‑specific membrane antigen (PSMA). Furthermore, the growth of PC cells is terminated with the downregulation of both AR and PSMA. In our preliminary experiments, it was also found that bortezomib (BZ; PS‑341) that inhibits 26S proteasome activity, acts as a downregulator of both PSMA and AR. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4706
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http://dx.doi.org/10.3892/ijo.2019.4706DOI Listing
February 2019
2 Reads

Metformin triggers the intrinsic apoptotic response in human AGS gastric adenocarcinoma cells by activating AMPK and suppressing mTOR/AKT signaling.

Int J Oncol 2019 Jan 30. Epub 2019 Jan 30.

Department of Pharmacy, Buddhist Tzu Chi General Hospital, Hualien 97002, Taiwan, R.O.C.

Metformin is commonly used to treat patients with type 2 diabetes and is associated with a decreased risk of cancer. Previous studies have demonstrated that metformin can act alone or in synergy with certain anticancer agents to achieve anti‑neoplastic effects on various types of tumors via adenosine monophosphate‑activated protein kinase (AMPK) signaling. However, the role of metformin in AMPK‑mediated apoptosis of human gastric cancer cells is poorly understood. Read More

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http://dx.doi.org/10.3892/ijo.2019.4704DOI Listing
January 2019

Partial agonistic effect of cetuximab on epidermal growth factor receptor and Src kinase activation in triple‑negative breast cancer cell lines.

Int J Oncol 2019 Jan 28. Epub 2019 Jan 28.

Department of Medical Pharmacology, Faculty of Medicine, University of Ankara, 06100 Ankara, Turkey.

Cetuximab is a monoclonal antibody developed to inhibit the binding of growth factors and the subsequent activation of epidermal growth factor receptor (EGFR). Triple‑negative breast cancer (TNBC) is resistant to cetuximab treatment. The aim of the present study was to examine the partial agonistic properties of cetuximab, which not only blocks ligand binding, but also partially triggers EGFR activation, which may lead to cetuximab resistance in TNBC. Read More

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http://dx.doi.org/10.3892/ijo.2019.4697DOI Listing
January 2019
1 Read

Mitochondrial calcium: Transport and modulation of cellular processes in homeostasis and cancer (Review).

Int J Oncol 2019 Jan 28. Epub 2019 Jan 28.

Department of Chronic-Degenerative Diseases, National Institute of Respiratory Diseases 'Ismael Cosío Villegas', CP 14080 Mexico City, Mexico.

In addition to their role in providing cellular energy, mitochondria fulfill a key function in cellular calcium management. The present review provides an integrative view of cellular and mitochondrial calcium homeostasis, and discusses how calcium regulates mitochondrial dynamics and functionality, thus affecting various cellular processes. Calcium crosstalk exists in the domain created between the endoplasmic reticulum and mitochondria, which is known as the mitochondria‑associated membrane (MAM), and controls cellular homeostasis. Read More

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http://dx.doi.org/10.3892/ijo.2019.4696DOI Listing
January 2019
1 Read

[Corrigendum] miR‑122 promotes proliferation and invasion of clear cell renal cell carcinoma by suppressing Forkhead box O3.

Int J Oncol 2019 Jan 23. Epub 2019 Jan 23.

Department of Urology, State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, PLA Medical School, Beijing 100853, P.R. China.

Following the publication of this paper, the authors have realized that two out of the three of the authors' address affiliations were not presented correctly. Essentially, the information provided in the first and third address affiliations was confused (and there is no third address affiliation applicable to this study), and the Chinese People's Liberation Army Hospital for the first affilation was presented incorrectly with a Weifang address. In spite of these errors in the affiliations, note that the corresponding author's address featured in the Correspondence box was presented correctly in the paper. Read More

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http://dx.doi.org/10.3892/ijo.2019.4694DOI Listing
January 2019
3 Reads

RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression.

Int J Oncol 2019 Jan 28. Epub 2019 Jan 28.

Zhongda Hospital Lishui Branch, Southeast University, Nanjing Lishui People's Hospital, Nanjing, Jiangsu 211200, P.R. China.

Breast cancer is one of the most common types of cancers which results in a high mortality rate for patients worldwide. In this study, we performed systematical experiments including tissue analysis (immunohistochemistry etc.) and cell functional experiments (cell counting assay, MTT assay, cell colony formation, cell migration assay, cell invasion assay etc. Read More

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http://dx.doi.org/10.3892/ijo.2019.4698DOI Listing
January 2019
1 Read

[Corrigendum] Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer.

Int J Oncol 2019 Jan 14. Epub 2019 Jan 14.

Department of Medical Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

After the publication of the article, the authors have realized that the affiliation presented for the joint co‑author listed on the paper (Jian‑Ren Tu) was incorrect. The correct author list (and affiliations) should therefore have been published as follows: Yu‑Hua Xu1*, Jian‑Ren Tu2*, Tian‑Tian Zhao3, Shi‑Guang Xie3 and Sheng‑Bo Tang4. 1Department of Cardiovascular Medicine, Jiangxi Chest Hospital, Nanchang 330006; 2Department of Oncology, Jiangxi Cancer Hospital, Nanchang 330029; Departments of 3Respiratory Medicine and 4Medical Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P. Read More

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http://dx.doi.org/10.3892/ijo.2019.4686DOI Listing
January 2019
1 Read

Profiling of apoptosis- and autophagy-associated molecules in human lung cancer A549 cells in response to cisplatin treatment using stable isotope labeling with amino acids in cell culture.

Int J Oncol 2019 Mar 18;54(3):1071-1085. Epub 2019 Jan 18.

Science Research Center, Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.

Cis‑diammine‑dichloro‑platinum II‑based adjuvant chemotherapy provides an alternative therapy to improve the survival of patients with lung tumors, especially those with non‑small cell lung cancer (NSCLC). However, drug resistance is a large clinical problem and its underlying mechanism remains unclear. In the present study, NSCLC A549 cells were treated with a low concentration of cisplatin in order to observe and determine the development of chemoresistance, via growth curves, colony forming assays and apoptosis assays. Read More

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http://dx.doi.org/10.3892/ijo.2019.4690DOI Listing
March 2019
1 Read

25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway.

Int J Oncol 2019 Mar 11;54(3):966-980. Epub 2019 Jan 11.

Department of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China.

Hyperlipidemia is associated with metastasis in patients with gastric cancer (GC). 25‑Hydroxycholesterol (25‑HC) is a type of oxysterol which is synthesized from cholesterol and is involved in a number of processes, including inflammation, immune responses and cancer development. However, the role of 25‑HC in gastric cancer remains unknown. Read More

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http://dx.doi.org/10.3892/ijo.2019.4684DOI Listing
March 2019
1 Read

Sphere‑forming assay vs. organoid culture: Determining long‑term stemness and the chemoresistant capacity of primary colorectal cancer cells.

Int J Oncol 2019 Mar 11;54(3):893-904. Epub 2019 Jan 11.

Molecular Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

Three‑dimensional (3D) cultures are indispensable for capturing tumor heterogeneity in colorectal cancer (CRC) in vitro. Although 3D cultures (such as sphere‑forming assay and organoid culture) can partially preserve the morphological and molecular characteristics of primary CRC, whether these 3D cultures maintain the long‑term stemness of cancer stem cells (CSCs) remains largely unknown. In the present study, spheres and organoids were generated side by side using individual primary CRC specimens, then respectively processed as serial passages. Read More

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http://dx.doi.org/10.3892/ijo.2019.4683DOI Listing
March 2019
1 Read

A novel splice mutation induces exon skipping of the EXT1 gene in patients with hereditary multiple exostoses.

Int J Oncol 2019 Mar 16;54(3):859-868. Epub 2019 Jan 16.

Department of Laboratory Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China.

The molecular mechanism of hereditary multiple exostoses (HME) remains ambiguous and a limited number of studies have investigated the pathogenic mechanism of mutations in patients with HME. In the present study, a novel heterozygous splice mutation (c.1284+2del) in exostosin glycosyltransferase 1 (EXT1) gene was identified in a three‑generation family with HME. Read More

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http://dx.doi.org/10.3892/ijo.2019.4688DOI Listing

MicroRNA‑98 suppresses cell growth and invasion of retinoblastoma via targeting the IGF1R/k‑Ras/Raf/MEK/ERK signaling pathway.

Int J Oncol 2019 Mar 17;54(3):807-820. Epub 2019 Jan 17.

Department of Ophthalmology, The First People's Hospital of Shangqiu, Shangqiu, Henan 476100, P.R. China.

Accumulating evidence has indicated that the dysregulation of microRNAs (miRNAs) is involved in the pathogenesis o retinoblastoma (RB); however, the potential role of miR‑98 in RB remains elusive. In the present study, it was demonstrated that miR‑98 is downregulated in RB tissues and cell lines, and its expression significantly associated with clinicopathological features, including differentiation, N classification and largest tumor base; patients with low miR‑98 expression levels exhibited significantly poorer overall survival. Overexpression of miR‑98 was suggested to suppress RB cell growth, migration and invasion. Read More

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http://dx.doi.org/10.3892/ijo.2019.4689DOI Listing

Arsenic‑induced BRCA1 CpG promoter methylation is associated with the downregulation of ERα and resistance to tamoxifen in MCF7 breast cancer cells and mouse mammary tumor xenografts.

Int J Oncol 2019 Mar 15;54(3):869-878. Epub 2019 Jan 15.

The University of Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA.

A significant percentage (~30%) of estrogen receptor‑α (ERα)‑positive tumors become refractory to endocrine therapies; however, the mechanisms responsible for this resistance remain largely unknown. Chronic exposure to arsenic through foods and contaminated water has been linked to an increased incidence of several tumors and long‑term health complications. Preclinical and population studies have indicated that arsenic exposure may interfere with endocrine regulation and increase the risk of breast tumorigenesis. Read More

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http://dx.doi.org/10.3892/ijo.2019.4687DOI Listing
March 2019
5 Reads

Inhibition of multiple myeloma‑derived exosomes uptake suppresses the functional response in bone marrow stromal cell.

Int J Oncol 2019 Mar 11;54(3):1061-1070. Epub 2019 Jan 11.

Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong 511436, P.R. China.

The communication between multiple myeloma (MM) cells and bone marrow stromal cells (BMSCs) serves a pivotal role in MM progression by supporting MM cell growth, proliferation and drug resistance. An exosomes‑based endogenous transport system has been determined as a novel mechanism of this communication by revealing the capacity for exchange of functional components between cells. An exosomes transfer‑mediated biological response in recipient cells is strongly determined by the detailed routes and mechanisms of exosomes internalization, which are diverse and can depend on surface molecules on the membrane of the vesicle and the recipient cell. Read More

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http://dx.doi.org/10.3892/ijo.2019.4685DOI Listing
March 2019
2 Reads

Muscleblind‑like 1 destabilizes Snail mRNA and suppresses the metastasis of colorectal cancer cells via the Snail/E‑cadherin axis.

Int J Oncol 2019 Mar 18;54(3):955-965. Epub 2019 Jan 18.

Department of Colorectal Cancer, Cancer Hospital of Tianjin Medical University, Key Laboratory of Cancer Prevention and Therapy, and National Clinical Research Center of Cancer, Tianjin 300060, P.R. China.

RNA‑binding proteins (RBPs) play a fundamental role in the recurrence and metastasis of colorectal cancer (CRC). In this study, we identified muscleblind‑like 1 (MBNL1), an RBP implicated in developmental control, as a robust suppressor of CRC cell metastasis in vitro. By using a scratch assay coupled with time‑lapse live cell imaging, our findings revealed that the knockdown of MBNL1 induced epithelial‑to‑mesenchymal transition (EMT)‑like morphological changes in the HCT‑116 cells, accompanied by an enhanced cell motility, and by the downregulation of E‑cadherin and the upregulation of Snail expression. Read More

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http://dx.doi.org/10.3892/ijo.2019.4691DOI Listing
March 2019
1 Read

Histone deacetylase 7 inhibits plakoglobin expression to promote lung cancer cell growth and metastasis.

Int J Oncol 2019 Mar 9;54(3):1112-1122. Epub 2019 Jan 9.

Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan, Hubei 430079, P.R. China.

Plakoglobin is a tumor suppressor gene in lung cancer; however, the mechanism by which it is downregulated in lung cancer is largely unknown. The aim of the present study was to investigate whether histone deacetylases (HDACs) regulate plakoglobin expression in lung cancer. The effects of overexpression or knockdown of HDAC7 on plakoglobin were determined using stably transfected lung cancer cell lines. Read More

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http://dx.doi.org/10.3892/ijo.2019.4682DOI Listing
March 2019
1 Read

Carboxypeptidase A4 accumulation is associated with an aggressive phenotype and poor prognosis in triple-negative breast cancer.

Int J Oncol 2019 Mar 4;54(3):833-844. Epub 2019 Jan 4.

Department of Diagnostic Pathology, Gunma University, Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.

Using whole transcriptome analysis and a lentiviral short hairpin RNA screening library, carboxypeptidase A4 (CPA4) was identified as a novel marker in breast cancer and a therapeutic target in triple‑negative breast cancer (TNBC) in the present study. Immunohistochemistry was used to evaluate the presence of CPA4, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki67, epidermal growth factor receptor, cytokeratin 5/6, aldehyde dehydrogenase 1, cluster of differentiation (CD)44, CD24, claudins, E‑cadherin, vimentin and androgen receptor in 221 cases of breast cancer, including 68 TNBC cases. The effects of CPA4 on the viability and migration ability of TNBC cells were analyzed using RNA interference methods. Read More

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http://dx.doi.org/10.3892/ijo.2019.4675DOI Listing

Stathmin gene silencing suppresses proliferation, migration and invasion of gastric cancer cells via AKT/sCLU and STAT3 signaling.

Int J Oncol 2019 Mar 3;54(3):1086-1098. Epub 2019 Jan 3.

Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China.

Globally, gastric cancer is the fifth most common malignancy, with high rates of incidence and mortality. The high mortality rate and poor prognosis of gastric cancer are closely associated with its profound invasiveness, high incidence of metastasis, rapid proliferation, and high rate of recurrence. Previous studies have confirmed that stathmin (STMN) has an important role in the occurrence, development and prognosis of gastric cancer. Read More

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http://dx.doi.org/10.3892/ijo.2019.4674DOI Listing

Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells.

Int J Oncol 2019 Mar 3;54(3):981-990. Epub 2019 Jan 3.

Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, Tsu 514‑8507, Japan.

The immunoglobulin enhancer‑binding factor/hepatic leukemia factor (E2A‑HLF) oncogenic fusion gene, generated by t(17;19)(q22;p13) translocation in childhood B‑cell acute lymphoblastic leukemia with a very poor prognosis, encodes a chimeric transcription factor in which the transactivation domains of E2A are fused to the DNA‑binding and dimerization domain of HLF. E2A‑HLF has been demonstrated to have an anti‑apoptotic effect. However, the molecular mechanism underlying E2A‑HLF‑mediated leukemogenesis remains unclear. Read More

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http://dx.doi.org/10.3892/ijo.2019.4673DOI Listing

Cancer-associated stroke: Pathophysiology, detection and management (Review).

Int J Oncol 2019 Mar 2;54(3):779-796. Epub 2019 Jan 2.

Laboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece.

Numerous types of cancer have been shown to be associated with either ischemic or hemorrhagic stroke. In this review, the epidemiology and pathophysiology of stroke in cancer patients is discussed, while providing vital information on the diagnosis and management of patients with cancer and stroke. Cancer may mediate stroke pathophysiology either directly or via coagulation disorders that establish a state of hypercoagulation, as well as via infections. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4669
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http://dx.doi.org/10.3892/ijo.2019.4669DOI Listing
March 2019
9 Reads

Roles of FGF8 subfamily in embryogenesis and oral‑maxillofacial diseases (Review).

Int J Oncol 2019 Mar 7;54(3):797-806. Epub 2019 Jan 7.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Fibroblast growth factors (FGFs) are diffusible polypeptides released by a variety of cell types. FGF8 subfamily members regulate embryonic development processes through controlling progenitor cell growth and differentiation, and are also functional in adults in tissue repair to maintain tissue homeostasis. FGF8 family members exhibit unique binding affinities with FGF receptors and tissue distribution patterns. Read More

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http://dx.doi.org/10.3892/ijo.2019.4677DOI Listing
March 2019
3.025 Impact Factor

Involvement of MAF1 homolog, negative regulator of RNA polymerase III in colorectal cancer progression.

Int J Oncol 2019 Mar 7;54(3):1001-1009. Epub 2019 Jan 7.

Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan.

Polymerase (Pol) III‑dependent transcription controls the abundance of transfer RNAs, 5S ribosomal RNA and small non‑coding RNAs within cells, and is known to serve an essential role in the maintenance of intracellular homeostasis. However, its contribution to cancer progression has not been extensively explored. The present study demonstrated that the evolutionarily conserved MAF1 homolog, negative regulator of RNA Pol III (MAF1) may be closely associated with malignant potential and poor prognosis in colorectal cancer (CRC). Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4678
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http://dx.doi.org/10.3892/ijo.2019.4678DOI Listing
March 2019
2 Reads

shRNA‑mediated knockdown of KNTC1 suppresses cell viability and induces apoptosis in esophageal squamous cell carcinoma.

Int J Oncol 2019 Mar 3;54(3):1053-1060. Epub 2019 Jan 3.

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing 100050, P.R. China.

Kinetochore‑associated proteins are critical components of mitotic checkpoints, which are essential for faithful chromosomal segregation and spindle assembly during cell division. Recent advances have demonstrated that kinetochore‑associated proteins are upregulated and serve significant roles in the carcinogenesis of numerous types of cancer. However, the effects of kinetochore‑associated protein 1 (KNTC1) on human cancer, particularly on esophageal squamous cell carcinoma (ESCC), remain unclear. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4672
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http://dx.doi.org/10.3892/ijo.2019.4672DOI Listing
March 2019
4 Reads

MicroRNA-200b and -301 are associated with gemcitabine response as biomarkers in pancreatic carcinoma cells.

Int J Oncol 2019 Mar 7;54(3):991-1000. Epub 2019 Jan 7.

Department of Molecular Cell Biology, The Jikei University School of Medicine, Tokyo 105-8461, Japan.

Chemotherapy resistance (congenital or acquired) is one of the principal challenges for the treatment of pancreatic carcinoma. Recent evidence has demonstrated that epithelial to mesenchymal transition (EMT) is associated with chemoresistance in pancreatic carcinoma cells. However, the molecular mechanism underlying the development of chemoresistance remains unknown, and limited therapeutic options are available. Read More

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http://dx.doi.org/10.3892/ijo.2019.4676DOI Listing

[Corrigendum] Pituitary sex hormones enhance the pro‑metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase‑1.

Int J Oncol 2019 Mar 3;54(3):1134. Epub 2019 Jan 3.

Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.

After the publication of the article, the authors realize that they overlooked stating that the author Magda Kucia was the recipient of an OPUS grant (grant no. UMO‑2016/21/B/NZ4/00201). Therefore, the Acknowledgements section of the paper should have read as follows (the added text is highlighted in bold): "This study was supported by NIH grants 2R01 DK074720 and R01HL112788, the Stella and Henry Endowment, and NCN Harmonia grant UMO‑2014/14/M/NZ3/00475 to M. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4670
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http://dx.doi.org/10.3892/ijo.2019.4670DOI Listing
March 2019
6 Reads

Long non‑coding RNA FOXD2‑AS1/miR‑150‑5p/PFN2 axis regulates breast cancer malignancy and tumorigenesis.

Int J Oncol 2019 Mar 3;54(3):1043-1052. Epub 2019 Jan 3.

Department of Breast Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China.

Breast cancer (BC) is a common cancer and leading cause of cancer‑associated mortality in women. Abnormal expression of long non‑coding RNA FOXD2 adjacent opposite strand RNA 1 (FOXD2‑AS1) was associated with the development of a number of tumors. However, whether FOXD2‑AS1 is dysregulated in BC and its underlying mechanisms remain unclear. Read More

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http://dx.doi.org/10.3892/ijo.2019.4671DOI Listing

miR‑3664‑5P suppresses the proliferation and metastasis of gastric cancer by attenuating the NF‑κB signaling pathway through targeting MTDH.

Int J Oncol 2019 Mar 8;54(3):845-858. Epub 2019 Jan 8.

Department of Gastrointestinal Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China.

Gastric cancer (GC) is one of the most common and fatal types of cancers worldwide and the specific mechanism has not been completely elucidated. microRNA (miR)‑3664‑5P has rarely been studied and the aim of the present study was to assess an association between miR‑3664‑5P and GC. Differences in miR‑3664‑5P expression in 100 GC (0. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4680
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March 2019
5 Reads

CP‑31398 attenuates endometrial cancer cell invasion, metastasis and resistance to apoptosis by downregulating MDM2 expression.

Int J Oncol 2019 Mar 9;54(3):942-954. Epub 2019 Jan 9.

Department of Imaging, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

Endometrial cancer (EC) is one of the most common malignancies of the female reproductive system, and metastasis is a major cause of mortality. In this study, we aimed to explore the role of CP‑31398 in the migration, invasion and apoptosis of EC cells by its regulation of the expression of the murine double minute 2 (MDM2) gene. For this purpose, EC tissues and adjacent normal tissues were collected, and the positive expression rate of MDM2 in these tissues was assessed. Read More

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http://dx.doi.org/10.3892/ijo.2019.4681DOI Listing
March 2019
4 Reads
3.025 Impact Factor

Long non‑coding RNA UCA1 confers tamoxifen resistance in breast cancer endocrinotherapy through regulation of the EZH2/p21 axis and the PI3K/AKT signaling pathway.

Int J Oncol 2019 Mar 8;54(3):1033-1042. Epub 2019 Jan 8.

Department of Breast Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

Tamoxifen is the gold standard for breast cancer endocrinotherapy. However, drug resistance remains a major limiting factor of tamoxifen treatment. Long non‑coding (lnc) RNA serves an important role in drug resistance; however, the molecular mechanisms of tamoxifen resistance in breast cancer endocrinotherapy are largely unclear. Read More

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http://dx.doi.org/10.3892/ijo.2019.4679DOI Listing

Phosphorylation of cortactin by cyclin-dependent kinase 5 modulates actin bundling by the dynamin 1-cortactin ring-like complex and formation of filopodia and lamellipodia in NG108-15 glioma-derived cells.

Int J Oncol 2019 Feb 11;54(2):550-558. Epub 2018 Dec 11.

Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Dynamin copolymerizes with cortactin to form a ring‑like complex that bundles and stabilizes actin filaments. Actin bundle formation is crucial for generation of filopodia and lamellipodia, which guide migration, invasion, and metastasis of cancer cells. However, it is unknown how the dynamin‑cortactin complex regulates actin bundle formation. Read More

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http://dx.doi.org/10.3892/ijo.2018.4663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317663PMC
February 2019

High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer.

Int J Oncol 2019 Feb 10;54(2):479-490. Epub 2018 Dec 10.

Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

Polo‑like kinase 4 (PLK4) has been identified as an oncogene, which is overexpressed in various types of human cancer; however, its role in colorectal cancer (CRC) development remains unknown. The present study demonstrated that PLK4 protein expression was upregulated in CRC tissues compared with in normal tissues through western blotting. In addition, immunohistochemical analysis of 39 CRC specimens further demonstrated that PLK4 protein expression was upregulated in 64. Read More

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http://dx.doi.org/10.3892/ijo.2018.4659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317648PMC
February 2019

From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review).

Int J Oncol 2019 Feb 10;54(2):407-419. Epub 2018 Dec 10.

Immunological and Oncological Center Cologne (IOZK), D-50674 Cologne, Germany.

The side effects of systemic chemotherapy used to treat cancer are often severe. For decades, oncologists have focused on treating the tumor, which may result in damage to the tumor‑bearing host and its immune system. Recently, much attention has been paid to the immune system of patients and its activation via biological therapies. Read More

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http://dx.doi.org/10.3892/ijo.2018.4661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317661PMC
February 2019

Mechanisms of metformin's anti‑tumor activity against gemcitabine‑resistant pancreatic adenocarcinoma.

Int J Oncol 2019 Feb 10;54(2):764-772. Epub 2018 Dec 10.

Department of Surgery, Keio University School of Medicine, Tokyo 160‑8582, Japan.

Metformin (MET) is the first‑line treatment for type 2 diabetes mellitus. Several epidemiological studies have suggested the potential anti‑cancer effects of MET, including its activity against pancreatic ductal adenocarcinoma (PDAC). Gemcitabine (GEM) has become the standard chemotherapy for PDAC; however, acquired resistance to GEM is a major challenge. Read More

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http://dx.doi.org/10.3892/ijo.2018.4662DOI Listing
February 2019
1 Read

Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially‑expressed circRNAs, lncRNAs, miRNAs and mRNAs.

Int J Oncol 2019 Feb 10;54(2):600-626. Epub 2018 Dec 10.

Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.

Autophagy has been reported to be involved in the occurrence and development of pancreatic cancer. However, the mechanism of autophagy‑associated non‑coding RNAs (ncRNAs) in pancreatic cancer remains largely unknown. In the present study, microarrays were used to detect differential expression of mRNAs, microRNAs (miRNAs), long ncRNAs (lncRNAs) and circular RNAs (circRNAs) post autophagy suppression by chloroquine diphosphate in PANC‑1 cells. Read More

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http://dx.doi.org/10.3892/ijo.2018.4660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317664PMC
February 2019
2 Reads

Lidocaine induces protective autophagy in rat C6 glioma cell line.

Int J Oncol 2019 Mar 14;54(3):1099-1111. Epub 2018 Dec 14.

Department of Histology and Embryology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 85-092 Bydgoszcz, Poland.

Malignant glioma is the most common type of brain cancer with poor prognosis. Surgical resection, chemotherapy and radiotherapy are the main therapeutic options; however, in addition to their insufficient efficacy, they are associated with the pain experienced by patients. To relieve pain, local anesthetics, such as lidocaine can be used. Read More

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http://dx.doi.org/10.3892/ijo.2018.4668DOI Listing

Hsp70 (HSP70A1A) downregulation enhances the metastatic ability of cancer cells.

Int J Oncol 2019 Mar 12;54(3):821-832. Epub 2018 Dec 12.

Department of General Biology, Michaelideion Cardiac Centre, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.

Heat shock protein 70 (Hsp70; also known as HSP70A1A) is one of the most induced proteins in cancer cells; however, its role in cancer has not yet been fully elucidated. In the present study, we proposed a hypothetical model in which the silencing of Hsp70 enhanced the metastatic properties of the HeLa, A549 and MCF7 cancer cell lines. We consider that the inability of cells to form cadherin‑catenin complexes in the absence of Hsp70 stimulates their detachment from neighboring cells, which is the first step of anoikis and metastasis. Read More

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http://dx.doi.org/10.3892/ijo.2018.4666DOI Listing