10,417 results match your criteria International Journal of Oncology [Journal]


FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway.

Int J Oncol 2019 Apr 22;54(4):1221-1232. Epub 2019 Feb 22.

Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.

Clear cell renal cell carcinoma (ccRCC) has been associated with one of the highest mortality rates among all cancers. Fatty acid binding proteins (FABPs) are 14‑15 kDa proteins that are highly abundant in the cytosol of most tissues. FABP5, a member of the FABP family, has been observed to promote tumor cell growth in numerous cancer types. Read More

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http://dx.doi.org/10.3892/ijo.2019.4721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411348PMC
April 2019
3 Reads

CGK062, a small chemical molecule, inhibits cancer upregulated gene 2‑induced oncogenesis through NEK2 and β‑catenin.

Int J Oncol 2019 Apr 22;54(4):1295-1305. Epub 2019 Feb 22.

BK21 Plus, Department of Cogno‑Mechatronics Engineering, Pusan National University, Busan 46241, Republic of Korea.

The mechanisms through which cancer‑upregulated gene 2 (CUG2), a novel oncogene, affects Wnt/β‑catenin signaling, essential for tumorigenesis, are unclear. In this study, we aimed to elucidate some of these mechanisms in A549 lung cancer cells. Under the overexpression of CUG2, the protein levels and activity of β‑catenin were evaluated by western blot analysis and luciferase assay. Read More

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http://dx.doi.org/10.3892/ijo.2019.4724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411349PMC

Vitamin D and its low calcemic analogs modulate the anticancer properties of cisplatin and dacarbazine in the human melanoma A375 cell line.

Int J Oncol 2019 Apr 25;54(4):1481-1495. Epub 2019 Feb 25.

Department of Histology, Faculty of Medicine, Medical University of Gdansk, 80‑211 Gdansk, Poland.

Melanoma represents a significant challenge in cancer treatment due to the high drug resistance of melanomas and the patient mortality rate. This study presents data indicating that nanomolar concentrations of the hormonally active form of vitamin D, 1α,25‑dihydroxyvitamin D3 [1α,25(OH)2D3], its non‑calcemic analogues 20S‑hydroxyvitamin D3 and 21‑hydroxypregnacalciferol, as well as the low‑calcemic synthetic analog calcipotriol, modulate the efficacy of the anticancer drugs cisplatin and dacarbazine. It was observed that vitamin D analogs sensitized melanoma A375 cells to hydrogen peroxide used as an inducer of oxidative stress. Read More

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http://dx.doi.org/10.3892/ijo.2019.4725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411347PMC

Netrin‑1 interference potentiates epithelial‑to‑mesenchymal transition through the PI3K/AKT pathway under the hypoxic microenvironment conditions of non‑small cell lung cancer.

Int J Oncol 2019 Apr 15;54(4):1457-1465. Epub 2019 Feb 15.

Department of Respiratory Medicine, Τhe Second Hospital Affiliated to Dalian Medical University, Dalian, Liaoning 116027, P.R. China.

Netrin‑1 is overexpressed in several types of cancer. However, whether netrin‑1 can potentiate hypoxia‑induced tumor progression in lung cancer has not been reported to date. Thus, the objective of the present study was to investigate whether netrin‑1 regulates cancer cell migration and invasion under hypoxic conditions in lung cancer and explore the underlying mechanism. Read More

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http://dx.doi.org/10.3892/ijo.2019.4716DOI Listing
April 2019
2 Reads

Diverse and cancer type‑specific roles of the p53 R248Q gain‑of‑function mutation in cancer migration and invasiveness.

Int J Oncol 2019 Apr 22;54(4):1168-1182. Epub 2019 Feb 22.

Department of Molecular Biology, International Institute of Molecular and Cell Biology, 02‑109 Warsaw, Poland.

Gain‑of‑function (GOF) mutations in the TP53 gene lead to acquisition of new functions by the mutated tumor suppressor p53 protein. A number of the over‑represented 'hot spot' mutations, including the ones in codons 175, 248 or 273, convey GOF phenotypes. Such phenotypes may include resistance to chemotherapeutics or changes in motility and invasiveness. Read More

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http://dx.doi.org/10.3892/ijo.2019.4723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411346PMC

Cathepsin B defines leader cells during the collective invasion of salivary adenoid cystic carcinoma.

Int J Oncol 2019 Apr 22;54(4):1233-1244. Epub 2019 Feb 22.

State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, Sichuan 610041, P.R. China.

Cathepsin B (CTSB) has been reported to be involved in cancer metastasis by altering extracellular matrix (ECM) remodeling and facilitating invasion. However, the contribution of CTSB to collective cell invasion in salivary adenoid cystic carcinoma (SACC) and the underlying mechanisms remain unclear. The present study demonstrated that collective cell invasion is commonly observed in SACC without a complete epithelial‑mesenchymal transition signature. Read More

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http://dx.doi.org/10.3892/ijo.2019.4722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411368PMC

Protective effect of curcumin against irinotecan‑induced intestinal mucosal injury via attenuation of NF‑κB activation, oxidative stress and endoplasmic reticulum stress.

Int J Oncol 2019 Apr 11;54(4):1376-1386. Epub 2019 Feb 11.

Department of General Surgery, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China.

Irinotecan (CPT‑11) is a DNA topoisomerase I inhibitor which is widely used in clinical chemotherapy, particularly for colorectal cancer treatment. However, late‑onset diarrhea is one of the severe side‑effects of this drug and this restricts its clinical application. The present study aimed to investigate the protective effects of curcumin treatment on CPT‑11‑induced intestinal mucosal injury both in vitro and in vivo and to elucidate the related mechanisms involved in these effects. Read More

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http://dx.doi.org/10.3892/ijo.2019.4714DOI Listing

Runx3 inhibits endothelial progenitor cell differentiation and function via suppression of HIF-1α activity.

Int J Oncol 2019 Apr 11;54(4):1327-1336. Epub 2019 Feb 11.

BK21 Plus KNU Multi-Omics Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.

Endothelial progenitor cells (EPCs) are bone marrow (BM)‑derived progenitor cells that can differentiate into mature endothelial cells, contributing to vasculogenesis in the blood vessel formation process. Runt‑related transcription factor 3 (RUNX3) belongs to the Runt domain family and is required for the differentiation of specific immune cells and neurons. The tumor suppressive role of RUNX3, via the induction of apoptosis and cell cycle arrest in a variety of cancers, and its deletion or frequent silencing by epigenetic mechanisms have been studied extensively; however, its role in the differentiation of EPCs is yet to be investigated. Read More

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http://dx.doi.org/10.3892/ijo.2019.4713DOI Listing
April 2019
1 Read
3.025 Impact Factor

miR‑300 regulates tumor proliferation and metastasis by targeting lymphoid enhancer‑binding factor 1 in hepatocellular carcinoma.

Int J Oncol 2019 Apr 13;54(4):1282-1294. Epub 2019 Feb 13.

Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.

Accumulating evidence indicates that microRNAs (miRNAs) have a critical role in cell proliferation and metastasis in hepatocellular carcinoma (HCC). However, the effect of miR‑300 on the development and progression of HCC remains unclear. In the present study, it was observed that miRNA (miR)‑300 expression was significantly decreased in HCC cell lines compared with normal liver cells. Read More

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http://dx.doi.org/10.3892/ijo.2019.4715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411350PMC
April 2019
3.025 Impact Factor

Iron metabolism and its contribution to cancer (Review).

Int J Oncol 2019 Apr 20;54(4):1143-1154. Epub 2019 Feb 20.

National Medical Centre of Colorectal Disease, The Third Affiliated Hospital, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210001, P.R. China.

Iron is an essential element for biological processes. Iron homeostasis is regulated through several mechanisms, from absorption by enterocytes to recycling by macrophages and storage in hepatocytes. Iron has dual properties, which may facilitate tumor growth or cell death. Read More

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http://dx.doi.org/10.3892/ijo.2019.4720DOI Listing

Adaptive EGF expression sensitizes pancreatic cancer cells to ionizing radiation through activation of the cyclin D1/P53/PARP pathway.

Int J Oncol 2019 Apr 19;54(4):1466-1480. Epub 2019 Feb 19.

Department of Radiation Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, P.R. China.

It is well-known that the activation status of the P53, signal transducer and activator of transcription (Stat)3 and nuclear factor (NF)‑κB signaling pathways determines the radiosensitivity of cancer cells. However, the function of these pathways in radiosensitive vs radioresistant cancer cells remains elusive. The present study demonstrated that adaptive expression of epidermal growth factor (EGF) following exposure to ionizing radiation (IR) may induce radiosensitization of pancreatic cancer (PC) cells through induction of the cyclin D1/P53/poly(ADP‑ribose) polymerase pathway. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4719
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http://dx.doi.org/10.3892/ijo.2019.4719DOI Listing
April 2019
3 Reads

Comparison of tumor‑targeting properties of directly and indirectly radioiodinated designed ankyrin repeat protein (DARPin) G3 variants for molecular imaging of HER2.

Int J Oncol 2019 Apr 11;54(4):1209-1220. Epub 2019 Feb 11.

Department of Immunology, Genetics and Pathology, Uppsala University, SE 75185 Uppsala, Sweden.

Evaluation of human epidermal growth factor receptor 2 (HER2) expression levels in breast and gastroesophageal cancer is used for the stratification of patients for HER2‑targeting therapies. The use of radionuclide molecular imaging may facilitate such evaluation in a non‑invasive way. Designed ankyrin repeat proteins (DARPins) are engineered scaffold proteins with high potential as probes for radionuclide molecular imaging. Read More

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http://dx.doi.org/10.3892/ijo.2019.4712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411343PMC
April 2019
2 Reads
3.025 Impact Factor

Silencing of COPB2 inhibits the proliferation of gastric cancer cells and induces apoptosis via suppression of the RTK signaling pathway.

Int J Oncol 2019 Apr 18;54(4):1195-1208. Epub 2019 Feb 18.

Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.

Emerging studies have reported that coatomer protein complex subunit β2 (COPB2) is overexpressed in several types of malignant tumor; however, to the best of our knowledge, no studies regarding COPB2 in gastric cancer have been published thus far. Therefore, the present study aimed to determine the significance and function of COPB2 in gastric cancer. COPB2 expression in gastric cancer cell lines was measured using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis. Read More

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http://dx.doi.org/10.3892/ijo.2019.4717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411345PMC
April 2019
4 Reads

COUP‑TFII promotes epithelial‑mesenchymal transition by inhibiting miR‑34a expression in colorectal cancer.

Int J Oncol 2019 Apr 18;54(4):1337-1344. Epub 2019 Feb 18.

First Affiliated Hospital, Huzhou University, The First People's Hospital of Huzhou, Huzhou, Zhejiang 313000, P.R. China.

Chicken ovalbumin upstream promoter‑transcription factor II (COUP‑TFII) expression is upregulated in colorectal cancer and is associated with its progression and a poor prognosis. The aim of the present study was to determine whether COUP‑TFII regulates colorectal cancer cell (CRC) invasion and migration by inhibiting microRNA (miR)‑34a. Transwell system and wound healing assays were performed to examine cell invasiveness and migration, respectively. Read More

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http://dx.doi.org/10.3892/ijo.2019.4718DOI Listing

[Corrigendum] LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling.

Int J Oncol 2019 Jun 2;54(6):2257. Epub 2019 Apr 2.

Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

Following the publication of this article, the authors have realized that the name of the second author was misspelt: "Minghai Dong" should have appeared as "Minhai Dong". The correct information for the authors on this paper is presented above. The authors regret that this error made it into print, andapologize to the readership for any inconvenience caused. Read More

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http://dx.doi.org/10.3892/ijo.2019.4769DOI Listing
June 2019
1 Read

Potentiation of mitotane action by rosuvastatin: New insights for adrenocortical carcinoma management.

Int J Oncol 2019 Jun 3;54(6):2149-2156. Epub 2019 Apr 3.

INSERM UMR‑S 1185, 94276 Le Kremlin‑Bicêtre Cedex, France.

Mitotane (also termed o,p'‑DDD) is the most effective therapy for advanced adrenocortical carcinoma (ACC). Mitotane‑induced dyslipidemia is treated with statins. Mitotane and statins are known to exert anti‑proliferative effects in vitro; however, the effects of statins have never been directly evaluated in patients with ACC and ACC cells, at least to the best of our knowledge. Read More

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http://dx.doi.org/10.3892/ijo.2019.4770DOI Listing
June 2019
3 Reads

Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma.

Int J Oncol 2019 Jun 29;54(6):2039-2053. Epub 2019 Mar 29.

Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Glioblastoma harbors frequent alterations in receptor tyrosine kinases, phosphatidylinositol‑3 kinase (PI3K) and phosphatase and tensin homolog (PTEN) that dysregulate phospholipid signaling driven tumor proliferation and therapeutic resistance. Myristoylated alanine‑rich C‑kinase substrate (MARCKS) is a 32 kDa intrinsically unstructured protein containing a polybasic (+13) effector domain (ED), which regulates its electrostatic sequestration of phospholipid phosphatidylinositol (4,5)‑bisphosphate (PIP2), and its binding to phosphatidylserine, calcium/calmodulin, filamentous actin, while also serving as a nuclear localization sequence. MARCKS ED is phosphorylated by protein kinase C (PKC) and Rho‑associated protein kinase (ROCK) kinases; however, the impact of MARCKS on glioblastoma growth and radiation sensitivity remains undetermined. Read More

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http://dx.doi.org/10.3892/ijo.2019.4766DOI Listing

Tumor‑suppressive microRNA‑223 targets WDR62 directly in bladder cancer.

Int J Oncol 2019 Jun 22;54(6):2222-2236. Epub 2019 Mar 22.

Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8520, Japan.

miRNA‑223 (miR‑223) has been reported to function not only as a tumor suppressor, but also as an oncogenic microRNA (miRNA or miR) in various cancer cells. Therefore, the functional role of miR‑223 has not been elucidated to date, at least to the best of our knowledge. We previously performed the deep sequencing analysis of clinical bladder cancer (BC) specimens. Read More

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http://dx.doi.org/10.3892/ijo.2019.4762DOI Listing
June 2019
2 Reads

MAT2B promotes proliferation and inhibits apoptosis in osteosarcoma by targeting epidermal growth factor receptor and proliferating cell nuclear antigen.

Int J Oncol 2019 Jun 27;54(6):2019-2029. Epub 2019 Mar 27.

Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.

Osteosarcoma (OS) is the most commonly diagnosed bone tumor in young people with poor prognosis. At present, the mechanisms underlying tumorigenesis in OS are not well understood. The methionine adnosyltransferase 2B (MAT2B) gene encodes the regulatory subunit of methionine adenosyltransferase (MAT). Read More

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http://dx.doi.org/10.3892/ijo.2019.4764DOI Listing

Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer.

Int J Oncol 2019 Jun 22;54(6):1943-1954. Epub 2019 Mar 22.

School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, P.R. China.

Immunoglobulin‑like transcript (ILT) 4, a negative regulator of immune response in allograft rejection, autoimmunity and infectious diseases, has recently been determined to serve important roles in tumor development. In the present study, the co‑expression of ILT4 and human leukocyte antigen‑G (HLA‑G) in tissues of human primary colorectal cancer (CRC) was revealed, and its association with older age, advanced stage, regional lymph node involvement and poor overall survival time was identified. In CRC cell lines, ILT4 and HLA‑G co‑expression and their autocrine regulation was demonstrated. Read More

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http://dx.doi.org/10.3892/ijo.2019.4761DOI Listing

C‑mannosylation of R‑spondin2 activates Wnt/β‑catenin signaling and migration activity in human tumor cells.

Int J Oncol 2019 Jun 1;54(6):2127-2138. Epub 2019 Apr 1.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa 223‑8522, Japan.

R‑spondin2 (Rspo2), one of the four members of the R‑spondin family of proteins, has agonistic activity in the Wnt/β‑catenin signaling pathway, and it is associated with normal development, as well as disease, such as cancer. The present study focused on the C‑mannosylation of Rspo2, which is a novel and unique type of glycosylation that occurs via a C‑C linkage between the tryptophan residue and an α‑mannose. Although Rspo2 has two putative C‑mannosylation sites at residues Trp150 and Trp153, it had not been reported to date whether these sites are C‑mannosylated. Read More

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http://dx.doi.org/10.3892/ijo.2019.4767DOI Listing

Benzyl isothiocyanate suppresses IGF1R, FGFR3 and mTOR expression by upregulation of miR-99a-5p in human bladder cancer cells.

Int J Oncol 2019 Jun 26;54(6):2106-2116. Epub 2019 Mar 26.

Division of Urology, School of Medicine, Fu-Jen Catholic University, New Taipei City 242, Taiwan, R.O.C.

Benzyl isothiocyanate (BITC) is known for its pharmacological properties against malignant neoplasm, including bladder cancer (BC). The current study investigated microRNAs (miRNA or miR) expression profiles with an emphasis on the role of miR‑99a‑5p in BITC‑treated BC cells. A quantitative polymerase chain reaction (qPCR) microarray containing 79 aberrantly expressed miRNAs in BC was used to detect miRNA expression in BITC‑treated cells. Read More

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http://dx.doi.org/10.3892/ijo.2019.4763DOI Listing

miR‑802 inhibits the aggressive behaviors of non‑small cell lung cancer cells by directly targeting FGFR1.

Int J Oncol 2019 Jun 29;54(6):2211-2221. Epub 2019 Mar 29.

Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, Department of Respiration, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.

Emerging reports have revealed that several microRNAs (miRNAs) are abnormally expressed in non‑small cell lung cancer (NSCLC). miRNAs have been identified as oncogenes or tumor suppressors, and regulate various biological processes including oncogenesis and development. miR‑802 is dysregulated in multiple types of human cancer, and exerts tumor‑suppressive or promoting roles. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4765
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http://dx.doi.org/10.3892/ijo.2019.4765DOI Listing
June 2019
7 Reads
3.025 Impact Factor

Droplet digital PCR as a novel system for the detection of microRNA‑34b/c methylation in circulating DNA in malignant pleural mesothelioma.

Int J Oncol 2019 Jun 1;54(6):2139-2148. Epub 2019 Apr 1.

Department of General Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan.

Malignant pleural mesothelioma (MPM) is a rare malignancy arising from the pleura that is difficult to diagnose, contributing to its dismal prognosis. Previously, we reported that the degree of microRNA (miR)‑34b/c methylation in circulating DNA is associated with the development of MPM. Herein, we present a newly developed droplet digital PCR (ddPCR)‑based assay for the detection of miR‑34b/c methylation in circulating DNA in patients with MPM. Read More

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http://dx.doi.org/10.3892/ijo.2019.4768DOI Listing
June 2019
2 Reads

Adrenergic modulation of AMPK‑dependent autophagy by chronic stress enhances cell proliferation and survival in gastric cancer.

Int J Oncol 2019 May 18;54(5):1625-1638. Epub 2019 Mar 18.

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.

Epidemiological data show that chronic stress has adverse effects on the incidence and progression of cancer. As a critical target organ for stress hormones, the stomach is frequently subjected to stress‑related injury. However, few reports regarding the association between stress and gastric cancer (GC) have been published. Read More

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http://dx.doi.org/10.3892/ijo.2019.4753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438426PMC
May 2019
3.025 Impact Factor

[Corrigendum] Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.

Int J Oncol 2019 Jun 18;54(6):2258. Epub 2019 Mar 18.

Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing 100044, P.R. China.

After the publication of the article, the authors retrospectively noticed that the first author affiliation was incorrectly split across three affiliations for the various parts of the same address. The correct author list (and affiliations) should therefore have been published as follows: Fengting Liu1, Lili Li1, Yanxia Li2, Xiaofang Ma3, Xiyun Bian2, Xiaozhi Liu2, Guowen Wang1* and Dianying Zhang3* 1Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060; 2Central Laboratory, The Fifth Central Hospital of Tianjin, Tianjin 300450; 3Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing 100044, P.R. Read More

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http://dx.doi.org/10.3892/ijo.2019.4752DOI Listing
June 2019
1 Read

Autophagy inhibitors regulate TRAIL sensitivity in human malignant cells by targeting the mitochondrial network and calcium dynamics.

Int J Oncol 2019 May 20;54(5):1734-1746. Epub 2019 Mar 20.

Division of Physiology, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo 173‑8610, Japan.

In a variety of cancer cell types, the pharmacological and genetic blockade of autophagy increases apoptosis induced by various anticancer drugs. These observations suggest that autophagy counteracts drug‑induced apoptosis. We previously reported that in human melanoma and osteosarcoma cells, autophagy inhibitors, such as 3‑methyladenine and chloroquine increased the sensitivity to apoptosis induced by tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL). Read More

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http://dx.doi.org/10.3892/ijo.2019.4760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438429PMC
May 2019
1 Read

α-hederin induces autophagic cell death in colorectal cancer cells through reactive oxygen species dependent AMPK/mTOR signaling pathway activation.

Int J Oncol 2019 May 19;54(5):1601-1612. Epub 2019 Mar 19.

Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China.

α‑hederin, a monodesmosidic triterpenoid saponin, had previously demonstrated strong anticancer effects. In the current study, the pharmacological mechanism of autophagic cell death induced by α‑hederin was investigated in human colorectal cancer cells. First, through cell counting kit‑8 and colony formation assays, it was demonstrated that α‑hederin could inhibit the proliferation of HCT116 and HCT8 cell. Read More

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http://dx.doi.org/10.3892/ijo.2019.4757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438428PMC
May 2019
2 Reads

MicroRNA-664 targets paired box protein 6 to inhibit the oncogenicity of pancreatic ductal adenocarcinoma.

Int J Oncol 2019 May 19;54(5):1884-1896. Epub 2019 Mar 19.

Department of Emergency, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China.

The abnormal expression of microRNAs (miRNAs or miRs) with oncogenic or tumor‑suppressive roles in pancreatic ductal adenocarcinoma (PDAC) has been widely reported in recent years, and these dysregulated miRNAs are implicated in the formation and progression of PDAC. Therefore, an investigation into the functional roles of miRNAs in PDAC may facilitate the identification of effective therapeutic targets. miRNA‑664 (miR‑664) has been found to be aberrantly expressed and to play crucial roles in several human cancer types. Read More

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http://dx.doi.org/10.3892/ijo.2019.4759DOI Listing
May 2019
1 Read

Reduction in MnSOD promotes the migration and invasion of squamous carcinoma cells.

Int J Oncol 2019 May 14;54(5):1639-1650. Epub 2019 Mar 14.

Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan, R.O.C.

Reactive oxygen species (ROS) homeostasis is maintained at a higher level in cancer cells, which promotes tumorigenesis. Oxidative stress induced by anticancer drugs may further increase ROS to promote apoptosis, but can also enhance the metastasis of cancer cells. The effects of ROS homeostasis on cancer cells remain to be fully elucidated. Read More

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http://dx.doi.org/10.3892/ijo.2019.4750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438424PMC
May 2019
3 Reads

The expression, significance and function of cancer susceptibility candidate 9 in lung squamous cell carcinoma: A bioinformatics and in vitro investigation.

Int J Oncol 2019 May 19;54(5):1651-1664. Epub 2019 Mar 19.

Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.

The cancer susceptibility candidate 9 (CASC9) gene has been reported to exert an oncogenic effect in several types of cancer. However, its role in lung squamous cell carcinoma (LUSC) is unknown. Therefore, the present study examined the expression of CASC9 in LUSC and non‑cancer tissues by reverse transcription‑quantitative polymerase chain reaction assays and by data mining of high‑throughput public databases, including The Cancer Genome Atlas, the Gene Expression Omnibus, ArrayExpress and the Cancer Cell Line Encyclopedia. Read More

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http://dx.doi.org/10.3892/ijo.2019.4758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439977PMC

Induction/reversal of drug resistance in gastric cancer by non-coding RNAs (Review).

Int J Oncol 2019 May 18;54(5):1511-1524. Epub 2019 Mar 18.

Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.

Gastric cancer (GC) is one of the most prevalent and malignant types of cancer worldwide. In China, it is the second most common type of cancer and the malignancy with the highest incidence and mortality rate. Chemotherapy for GC is not always effective due to the development of drug resistance. Read More

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http://dx.doi.org/10.3892/ijo.2019.4751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438417PMC
May 2019
1 Read

Oral mucosal mesenchymal stem cell‑derived exosomes: A potential therapeutic target in oral premalignant lesions.

Int J Oncol 2019 May 19;54(5):1567-1578. Epub 2019 Mar 19.

Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.

Emerging evidence indicates that mesenchymal stem cells (MSCs) serve an indispensable role in the tumor microenvironment. However, whether MSCs participate in the development of oral carcinogenesis remains unclear. The present study isolated MSCs from clinical tissues and investigated the differences of MSCs derived from normal oral mucosa (N‑MSC), oral leukoplakia with dysplasia (LK‑MSC) and oral carcinoma (Ca‑MSC). Read More

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http://dx.doi.org/10.3892/ijo.2019.4756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438436PMC
May 2019
1 Read
3.025 Impact Factor

Sodium-coupled monocarboxylate transporter is a target of epigenetic repression in cervical cancer.

Int J Oncol 2019 May 14;54(5):1613-1624. Epub 2019 Mar 14.

Biomedical Unit for Cancer Research, Carcinogenesis Laboratory, Department of Basic Research, Instituto de Investigaciones Biomédicas, UNAM/Instituto Nacional de Cancerologia (INCan), Mexico City 14080, Mexico.

The SLC5A8 gene encodes Na monocarboxylate transporter 1, which is epigenetically inactivated in various tumour types. This has been attributed to the fact that it prevents the entry of histone deacetylase (HDAC) inhibitors and favours the metabolic reprogramming of neoplastic cells. Nevertheless, its expression and regulation in cervical cancer (CC) have not been elucidated to date. Read More

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http://dx.doi.org/10.3892/ijo.2019.4749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438420PMC
May 2019
2 Reads

MYB promotes the growth and metastasis of salivary adenoid cystic carcinoma.

Int J Oncol 2019 May 18;54(5):1579-1590. Epub 2019 Mar 18.

Central Laboratory, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 10081, P.R. China.

The incidence of recurrent t(6;9) translocation of the MYB proto‑oncogene to NFIB (the gene that encodes nuclear factor 1 B‑type) in adenoid cystic carcinoma (ACC) tumour tissues is high. However, MYB [the gene that encodes transcriptional activator Myb (MYB)] overexpression is more common, indicating that MYB serves a key role in ACC. The current study aimed to investigate the role of MYB in salivary (S)ACC growth and metastasis. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4754
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http://dx.doi.org/10.3892/ijo.2019.4754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438425PMC
May 2019
7 Reads

Human papillomavirus infection and ocular surface disease (Review).

Int J Oncol 2019 May 19;54(5):1503-1510. Epub 2019 Mar 19.

Department of Ophthalmology, University Hospital of Heraklion, 71110 Heraklion, Greece.

Human papillomavirus (HPV) infection has been implicated as a primary cause of lesions in the anogenital region, skin, oropharynx and respiratory tract. Additionally, the role of HPV in the pathogenesis of ocular surface disease has also been extensively studied. Conjunctival papilloma development has been strongly associated with the HPV infection of certain subtypes. Read More

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http://dx.doi.org/10.3892/ijo.2019.4755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438422PMC
May 2019
1 Read

Tubastatin A, an inhibitor of HDAC6, enhances temozolomide‑induced apoptosis and reverses the malignant phenotype of glioblastoma cells.

Int J Oncol 2019 May 1;54(5):1797-1808. Epub 2019 Mar 1.

Department of Biochemistry and Genetics, University of Navarra School of Sciences, 31008 Pamplona, Spain.

Glioblastoma or grade IV astrocytoma is the most common and lethal form of glioma. Current glioblastoma treatment strategies use surgery followed by chemotherapy with temozolomide. Despite this, numerous glioblastoma cases develop resistance to temozolomide treatments, resulting in a poor prognosis for the patients. Read More

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http://dx.doi.org/10.3892/ijo.2019.4739DOI Listing

Mesenchymal stem cell‑derived extracellular vesicles promote the in vitro proliferation and migration of breast cancer cells through the activation of the ERK pathway.

Int J Oncol 2019 May 13;54(5):1843-1852. Epub 2019 Mar 13.

Jiangsu Key Laboratory of Clinical Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.

Mesenchymal stem cells (MSCs) have been demonstrated to be involved in tumor progression and the modulation of the tumor microenvironment, partly through their secretome. Extracellular vesicles (EVs) are membranous nanovesicles secreted by multiple types of cells and have been demonstrated to mediate intercellular communication in both physiological and pathological conditions. However, numerous questions still remain regarding the underlying mechanisms and functional consequences of these interactions. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4747
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http://dx.doi.org/10.3892/ijo.2019.4747DOI Listing
May 2019
4 Reads

Interferon-β sensitizes human malignant melanoma cells to temozolomide-induced apoptosis and autophagy.

Int J Oncol 2019 May 7;54(5):1864-1874. Epub 2019 Mar 7.

Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo 173-8610, Japan.

Malignant melanoma is a highly aggressive skin cancer that is highly resistant to chemotherapy. Adjuvant therapy is administered to patients with melanoma that possess no microscopic metastases or have a high risk of developing microscopic metastases. Methylating agents, including dacarbazine (DTIC) and temozolomide (TMZ), pegylated interferon (IFN)‑α2b and interleukin‑2 have been approved for adjuvant immuno‑chemotherapy; however, unsatisfactory results have been reported following the administration of methylating agents. Read More

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http://dx.doi.org/10.3892/ijo.2019.4743DOI Listing

[Corrigendum] Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK‑mediated DR5 regulation in colorectal cancer.

Int J Oncol 2019 May 13;54(5):1897. Epub 2019 Mar 13.

Department of Internal Medicine and Rescearch Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju 561-712, Korea.

Following the publication of this article, an interested reader drew to our attention that Fig. 1C contained an important flaw. The Figure shows a western blot for LCN2, DR4, DR5, and actin, and it was noted that the identical bands shown for actin were also featured in a paper by the same authors published in 2017 [Lipocalin 2 negatively regulates cell proliferation and epithelial to mesenchymal transition through changing metabolic gene expression in colorectal cancer. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4748
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http://dx.doi.org/10.3892/ijo.2019.4748DOI Listing
May 2019
5 Reads

Proteomics profiling of plasma exosomes in epithelial ovarian cancer: A potential role in the coagulation cascade, diagnosis and prognosis.

Int J Oncol 2019 May 7;54(5):1719-1733. Epub 2019 Mar 7.

Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.

Ovarian cancer remains the most lethal type of cancer among all gynecological malignancies. The majority of patients are diagnosed with ovarian cancer at the late stages of the disease. Therefore, there exists an imperative need for the development of early ovarian cancer diagnostic techniques. Read More

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http://dx.doi.org/10.3892/ijo.2019.4742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438431PMC
May 2019
1 Read
3.025 Impact Factor

Solamargine inhibits gastric cancer progression by regulating the expression of lncNEAT1_2 via the MAPK signaling pathway.

Int J Oncol 2019 May 12;54(5):1545-1554. Epub 2019 Mar 12.

Department of Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, P.R. China.

Solamargine, a derivative from the steroidal solasodine in Solanum species, has exhibited anticancer activities in numerous types of cancer; however, its role in gastric cancer (GC) remains unknown. In the present study, it was demonstrated that Solamargine suppressed the viability of five gastric cancer cell lines in a dose‑dependent manner and induced notable alterations in morphology. Treatment with Solamargine promoted cell apoptosis (P<0. Read More

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http://dx.doi.org/10.3892/ijo.2019.4744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438418PMC
May 2019
1 Read

Extracellular vesicle‑delivered miR‑505‑5p, as a diagnostic biomarker of early lung adenocarcinoma, inhibits cell apoptosis by targeting TP53AIP1.

Int J Oncol 2019 May 1;54(5):1821-1832. Epub 2019 Mar 1.

Department of Oncology, Beijing Chao‑Yang Hospital, Capital Medical University, Beijing 100020, P.R. China.

Lung adenocarcinoma (LA) is the most commonly occurring histological type of non‑small cell lung cancer. Diagnosis and treatment of LA remain a major clinical challenge. In the present study, to identify early LA biomarkers, extracellular vesicles (EVs) were separated from the plasma samples from 153 patients with LA and 75 healthy controls. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4738
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http://dx.doi.org/10.3892/ijo.2019.4738DOI Listing
May 2019
4 Reads

TOPK is regulated by PP2A and BCR/ABL in leukemia and enhances cell proliferation.

Int J Oncol 2019 May 5;54(5):1785-1796. Epub 2019 Mar 5.

Department of Hematology, Tokyo Medical and Dental University, Tokyo 113‑8519, Japan.

Although treatment of chronic myeloid leukemia (CML) has improved with the development of tyrosine kinase inhibitors (TKIs), patients develop fatal blast crisis (BC) whilst receiving TKI treatment. Alternative treatments for cases resistant to TKIs are required. A serine/threonine protein kinase, T‑lymphokine‑activated killer cell‑originated protein kinase (TOPK), is highly expressed in various malignant tumors. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4740
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http://dx.doi.org/10.3892/ijo.2019.4740DOI Listing
May 2019
11 Reads

Reversine induces cell cycle arrest and apoptosis via upregulation of the Fas and DR5 signaling pathways in human colorectal cancer cells.

Int J Oncol 2019 May 13;54(5):1875-1883. Epub 2019 Mar 13.

Department of Internal Medicine, Chonnam National University Medical School, Gwangju 501-757, Republic of Korea.

Reversine, a 2,6‑diamino‑substituted purine analogue, has been reported to be effective in tumor suppression via induction of cell growth arrest and apoptosis of cancer cells. However, it remains unclear whether reversine exerts anticancer effects on human colorectal cancer cells. In the present study, in vitro experiments were conducted to investigate the anticancer properties of reversine in human colorectal cancer cells. Read More

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http://dx.doi.org/10.3892/ijo.2019.4746DOI Listing
May 2019
1 Read

Targeting excessive MYCN expression using MLN8237 and JQ1 impairs the growth of hepatoblastoma cells.

Int J Oncol 2019 May 5;54(5):1853-1863. Epub 2019 Mar 5.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, D‑80337 Munich, Germany.

Hepatoblastoma (HB) is the most common liver tumor in children under the age of 3 years worldwide. While many patients achieve good outcomes with surgical resection and conventional chemotherapy, there is still a high‑risk population that exhibits a poor treatment response and unfavorable prognosis, which warrants the search for novel treatment options. In recent years, it has become clear that genetic events alone are not sufficient to explain the aggressive phenotype of this embryonal malignancy. Read More

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http://dx.doi.org/10.3892/ijo.2019.4741DOI Listing
May 2019
1 Read

Role of tumor‑derived extracellular vesicles in cancer progression and their clinical applications (Review).

Int J Oncol 2019 May 12;54(5):1525-1533. Epub 2019 Mar 12.

School of Medicine, Soochow University, Suzhou, Jiangsu 215123, P.R. China.

Extracellular vesicles (EVs), including micro‑vesicles and exosomes, are heterogeneous small membranous vesicles shed from the surface of myriad cells and are crucial in mediating intercellular communication. The vertical trafficking of cargo to the plasma membrane and subsequent redistribution of surface lipids may contribute to EV formation. Tumor‑derived extracellular vesicles (TD‑EVs) can carry complex, bioactive cargo, such as nucleic acids and proteins, during tumor metastasis. Read More

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http://dx.doi.org/10.3892/ijo.2019.4745DOI Listing

Isoforms S and L of MRPL33 from alternative splicing have isoform‑specific roles in the chemoresponse to epirubicin in gastric cancer cells via the PI3K/AKT signaling pathway.

Int J Oncol 2019 May 27;54(5):1591-1600. Epub 2019 Feb 27.

Department of Oncology, The Changhai Hospital, Shanghai 200433, P.R. China.

Drug resistance is a major cause of cancer‑associated mortality. Epirubicin‑based chemotherapy initially benefits patients with metastatic or advanced gastric cancer; however, tumor recurrence can occur following several courses of treatment. Mitochondrial ribosomal protein L33 (MRPL33)‑long (L) and MRPL33‑short (S), isoforms of MRPL33 that arise from AS, have been reported to regulate cell growth and apoptosis in cancer; however, few studies have evaluated the roles of MRPL33‑L and MRPL33‑S in gastric cancer. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4728
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http://dx.doi.org/10.3892/ijo.2019.4728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438423PMC
May 2019
1 Read
3.025 Impact Factor

Silencing of lysyl oxidase‑like 2 inhibits the migration, invasion and epithelial‑to‑mesenchymal transition of renal cell carcinoma cells through the Src/FAK signaling pathway.

Authors:
Xi Hong Jian-Jun Yu

Int J Oncol 2019 May 27;54(5):1676-1690. Epub 2019 Feb 27.

Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.

The aim of the present study was to investigate the effects of lysyl oxidase‑like 2 (LOXL2) on the invasion, migration and epithelial‑to‑mesenchymal transition (EMT) of renal cell carcinoma (RCC) cells through the steroid receptor coactivator (Src)/focal adhesion kinase (FAK) signaling pathway. RCC tissues and adjacent normal tissues were collected from 80 patients with RCC. Immunohistochemistry was used to determine the positive expression rate of the LOXL2 protein. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4726
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http://dx.doi.org/10.3892/ijo.2019.4726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438419PMC
May 2019
7 Reads

Bladder cancer cells interact with vascular endothelial cells triggering EGFR signals to promote tumor progression.

Int J Oncol 2019 May 27;54(5):1555-1566. Epub 2019 Feb 27.

Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

Although important progress has been made in elucidating the role of the tumor microenvironment in the development of bladder cancer, little is currently known regarding the interactions with vascular endothelial cells (ECs) that promote cancer progression. In the present study, it is reported that epidermal growth factor receptor ligands induced by the upregulation of vascular endothelial growth factor (VEGF)‑A and VEGF‑C via the VEGF receptor (R)2/nuclear factor‑κB signaling pathway in ECs, may trigger EGFR signaling in bladder cancer cells and promote bladder cancer progression. Furthermore, the interaction between bladder cancer cells and ECs enhanced EC recruitment though the CXCL1/CXCL5/CXCL8‑CXCR2 pathway. Read More

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http://dx.doi.org/10.3892/ijo.2019.4729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438427PMC