7,981 results match your criteria International Journal of Obesity[Journal]


Author Correction: Data visualisation to support obesity policy: case studies of data tools for planning and transport policy in the UK.

Int J Obes (Lond) 2019 Feb 15. Epub 2019 Feb 15.

UKCRC Centre for Diet and Activity Research (CEDAR), MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.

In the original version of this Article the following funding details were omitted from the Acknowledgements section. Read More

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http://dx.doi.org/10.1038/s41366-019-0337-9DOI Listing
February 2019

Metabolic improvement in obese patients after duodenal-jejunal exclusion is associated with intestinal microbiota composition changes.

Int J Obes (Lond) 2019 Feb 14. Epub 2019 Feb 14.

Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

Background: Intestinal microbiota have been suggested to play an important role in the pathogenesis of obesity and type 2 diabetes. Bariatric surgery improves both conditions and has been associated with changes in intestinal microbiota composition. We investigated the effect of a nonsurgical bariatric technique on intestinal microbiota composition in relation to metabolic improvement. Read More

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http://dx.doi.org/10.1038/s41366-019-0336-xDOI Listing
February 2019

Does birth mode modify associations of maternal pre-pregnancy BMI and gestational weight gain with the infant gut microbiome?

Int J Obes (Lond) 2019 Feb 14. Epub 2019 Feb 14.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background: Mother-to-newborn transmission of obesity-associated microbiota may be modified by birth mode (vaginal vs. Cesarean delivery). Prospective data to test this hypothesis are still sparse. Read More

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http://dx.doi.org/10.1038/s41366-018-0273-0DOI Listing
February 2019

The effects of a teaching intervention on weight bias among kinesiology undergraduate students.

Int J Obes (Lond) 2019 Feb 12. Epub 2019 Feb 12.

Department of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX, USA.

Objectives: Weight bias is present among kinesiology professionals and this may cause a significant negative impact on their clients with obesity. Thus, our objective was to test if learning about uncontrollable cause of obesity and about weight bias would reduce explicit and implicit weight bias among kinesiology undergraduate students compared to the traditional curriculum which is more focused on controllable causes of weight gain.

Methods: We recruited undergraduates from two classes of the same kinesiology major course taught by the same instructor. Read More

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http://dx.doi.org/10.1038/s41366-019-0325-0DOI Listing
February 2019

Medical marijuana-an obesity problem or opportunity?

Int J Obes (Lond) 2019 Feb 12. Epub 2019 Feb 12.

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.

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http://dx.doi.org/10.1038/s41366-019-0334-zDOI Listing
February 2019

Disparities in childhood overweight and obesity by income in the United States: an epidemiological examination using three nationally representative datasets.

Int J Obes (Lond) 2019 Feb 4. Epub 2019 Feb 4.

Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Public Health Research Center, 921 Assembly St. rm 130, Columbia, SC, 29201, USA.

Background/objectives: Overweight and obesity (OWOB) is a global epidemic. Adults and adolescents from low-income households are at higher risk to be OWOB. This study examined the relationship between income and OWOB prevalence in children and adolescents (518 years) in the United States (US) within and across race/ethnicities, and changes in this relationship from 1971 to 2014. Read More

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http://dx.doi.org/10.1038/s41366-019-0331-2DOI Listing
February 2019

Childhood growth patterns and cardiovascular autonomic modulation in midlife: Northern Finland 1966 Birth Cohort Study.

Int J Obes (Lond) 2019 Feb 4. Epub 2019 Feb 4.

Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

Objectives: To test the hypothesis that age and body mass index (BMI) at BMI peak during infancy and at BMI rebound in childhood are related to cardiovascular autonomic modulation in adulthood.

Methods: At the age of 46 years, a sample (n = 5861) of the participants of the Northern Finland Birth Cohort 1966 took part in follow-up examinations. Heart rate variability (HRV), baroreflex sensitivity (BRS) and low-frequency oscillations of systolic blood pressure (LF) were measured during sympathetic stimulus by standing. Read More

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http://dx.doi.org/10.1038/s41366-019-0333-0DOI Listing
February 2019
1 Read

Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice.

Int J Obes (Lond) 2019 Feb 4. Epub 2019 Feb 4.

College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture; Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, 100083, Beijing, China.

Objective: Resveratrol (RSV) is a natural polyphenol with putative anti-obesity effects; however, its mechanisms of action remain unclear due to its low bioavailability. Microbial functions in the physiology result from the microbiota-host coevolution has profoundly affected host metabolism. Here, we sought to determine how beneficial microbiome caused by RSV interventions affects antiobesity. Read More

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http://www.nature.com/articles/s41366-019-0332-1
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http://dx.doi.org/10.1038/s41366-019-0332-1DOI Listing
February 2019
6 Reads

Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS.

Int J Obes (Lond) 2019 Feb 4. Epub 2019 Feb 4.

Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.

Background: Adiposity rebound (AR), the second BMI rise in childhood at around the age of 6 years, is associated with obesity and metabolic alteration in later life. Given that polycystic ovary syndrome (PCOS) has a strong metabolic component, early life growth patterns could reveal a risk of PCOS. Thus, we aimed to investigate the associations between age at AR and PCOS diagnosis and BMI later in life. Read More

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http://dx.doi.org/10.1038/s41366-019-0318-zDOI Listing
February 2019
2 Reads

Unlike calorie restriction, Roux-en-Y gastric bypass surgery does not increase hypothalamic AgRP and NPY in mice on a high-fat diet.

Int J Obes (Lond) 2019 Feb 4. Epub 2019 Feb 4.

Department of Nutritional Sciences, College of Human Sciences, Texas Tech University, Lubbock, TX, 79409, USA.

Objectives: Dieting often fails because weight loss triggers strong counter-regulatory biological responses such as increased hunger and hypometabolism that are thought to be critically dependent on the master fuel sensor in the mediobasal hypothalamus (MBH). Because prolonged starvation has been shown to increase AgRP and NPY, the expression level of these two orexigenic genes has been taken as an experimental readout for the presence or absence of hunger. Roux-en-Y gastric bypass (RYGB) surgery leads to a significant weight loss without inducing the associated hunger, indicating possible changes in hypothalamic neuropeptides and/or signaling. Read More

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http://dx.doi.org/10.1038/s41366-019-0328-xDOI Listing
February 2019

Joint associations between weekday and weekend physical activity or sedentary time and childhood obesity.

Int J Obes (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Pennington Biomedical Research Center, Baton Rouge, LA, USA.

Objective: To evaluate the single and joint associations of objectively measured moderate-to-vigorous physical activity (MVPA) and sedentary time on week and weekend days with obesity in children from 12 countries across all inhabited continents.

Methods: A multinational, 12-country cross-sectional study of 5779 children aged 9-11 years was conducted. Time spent in MVPA and sedentary behaviors was assessed by waist-worn accelerometry. Read More

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http://dx.doi.org/10.1038/s41366-019-0329-9DOI Listing
January 2019
1 Read

Even a low dose of tamoxifen profoundly induces adipose tissue browning in female mice.

Int J Obes (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, and School of Molecular Biosciences, Washington State University, Pullman, WA, 99164, USA.

Background: Tamoxifen-inducible Cre/lox site-specific recombination technology has been widely used to generate conditional transgenic mice. As an estrogen receptor ligand, tamoxifen itself potentially affects energy metabolism, which may confound interpretation of data especially in metabolic studies. Considering sexual dimorphism, in this study, the effects of low-dose tamoxifen administration on energy metabolism, and browning of adipose tissues in female and male mice were investigated. Read More

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http://dx.doi.org/10.1038/s41366-019-0330-3DOI Listing
January 2019

Defective fasting-induced PKA activation impairs adipose tissue glycogen degradation in obese Zucker rats.

Int J Obes (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Department of Physiology, University of Melbourne, Parkville, 3010, VIC, Australia.

Background: Obesity is associated with development of insulin resistance in adipose tissue (AT). Human obesity has been associated with increased glycogen deposition in adipocytes. Adipocytes synthesise glycogen prior to the formation of lipids. Read More

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http://dx.doi.org/10.1038/s41366-019-0327-yDOI Listing
January 2019

Meal timing and obesity: interactions with macronutrient intake and chronotype.

Int J Obes (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.

Background: Timing of dietary intake may play a role in obesity. However, previous studies produced mixed findings possibly due to inconsistent approaches to characterize meal timing and not taking into account chronotype and macronutrients. To address the aforementioned limitations, we have defined meal timing relative to sleep/wake timing, investigated the relationship between meal timing and body mass index (BMI) dependent on chronotype, and examined the associations. Read More

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http://dx.doi.org/10.1038/s41366-018-0284-xDOI Listing
January 2019

Screening and brief intervention for obesity in primary care: cost-effectiveness analysis in the BWeL trial.

Int J Obes (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK.

Background: The Brief Intervention for Weight Loss Trial enrolled 1882 consecutively attending primary care patients who were obese and participants were randomised to physicians opportunistically endorsing, offering, and facilitating a referral to a weight loss programme (support) or recommending weight loss (advice). After one year, the support group lost 1.4 kg more (95%CI 0. Read More

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http://dx.doi.org/10.1038/s41366-018-0295-7DOI Listing
January 2019

Maternal metabolic factors during pregnancy predict early childhood growth trajectories and obesity risk: the CANDLE Study.

Int J Obes (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

Background: We investigated the individual and additive effects of three modifiable maternal metabolic factors, including pre-pregnancy overweight/obesity, gestational weight gain (GWG), and gestational diabetes mellitus (GDM), on early childhood growth trajectories and obesity risk.

Methods: A total of 1425 mother-offspring dyads (953 black and 472 white) from a longitudinal birth cohort were included in this study. Latent class growth modeling was performed to identify the trajectories of body mass index (BMI) from birth to 4 years in children. Read More

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http://dx.doi.org/10.1038/s41366-019-0326-zDOI Listing
January 2019
2 Reads

Association of obesity with morbidity and mortality in critically ill children: a systematic review and meta-analysis of observational studies.

Int J Obes (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Recent studies have suggested that obesity might be protective in specific conditions such as critical illness; however, there are controversial data in critically ill children with obesity. The aim of this study was to investigate the association of obesity with mortality and other outcomes in these patients. We conducted a systematic review of observational studies investigating obesity in critically ill children, published by August 2017 in PubMed and Scopus. Read More

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http://www.nature.com/articles/s41366-019-0319-y
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http://dx.doi.org/10.1038/s41366-019-0319-yDOI Listing
January 2019
3 Reads

Long-term diabetes outcomes after bariatric surgery-managing medication withdrawl.

Int J Obes (Lond) 2019 Jan 29. Epub 2019 Jan 29.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, Porto, Portugal.

Background/objectives: Bariatric surgery leads to type 2 diabetes mellitus (T2DM) remission, but recurrence can ensue afterwards. However, literature provides heterogenous remission/recurrence criteria and there is no consensus on long-term T2DM management after surgery. We aim to assess T2DM remission/recurrence rates using standardized criteria and to identify relapse predictors. Read More

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http://www.nature.com/articles/s41366-019-0320-5
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http://dx.doi.org/10.1038/s41366-019-0320-5DOI Listing
January 2019
6 Reads

Obesity is associated with altered gene expression in human tastebuds.

Int J Obes (Lond) 2019 Jan 29. Epub 2019 Jan 29.

CSIRO Health and Biosecurity, Sydney, Australia.

Background: The role of taste perception in the development and persistence of obesity is currently unclear due to conflicting results from psychophysical and other studies. No study to date has assessed whether there is an underlying fundamental difference in the physiology of taste tissue between lean and obese individuals.

Method/subjects: We analysed the transcriptomic profile (RNA-seq) of human fungiform taste papillae biopsied from lean (n = 23) and obese (n = 13) Caucasian females (age range 18-55) to identify differences in gene expression. Read More

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http://dx.doi.org/10.1038/s41366-018-0303-yDOI Listing
January 2019

Neighborhood racial/ethnic segregation and BMI: A longitudinal analysis of the Multi-ethnic Study of Atherosclerosis.

Int J Obes (Lond) 2019 Jan 22. Epub 2019 Jan 22.

Department of Epidemiology & Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.

Background: Current knowledge regarding the relationship between segregation and body weight is derived mainly from cross-sectional data. Longitudinal studies are needed to provide stronger causal inference.

Methods: We use longitudinal data from the Multi-Ethnic Study of Atherosclerosis and apply an econometric fixed-effect strategy, which accounts for all time-invariant confounders, and compare results to conventional cross-sectional analyses. Read More

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http://dx.doi.org/10.1038/s41366-019-0322-3DOI Listing
January 2019

Maternal antibiotic use during pregnancy and childhood obesity at age 5 years.

Int J Obes (Lond) 2019 Jan 22. Epub 2019 Jan 22.

Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA, USA.

Objective: The benefits of antibiotic treatment during pregnancy are immediate, but there may be long-term risks to the developing child. Prior studies show an association between early life antibiotics and obesity, but few have examined this risk during pregnancy.

Subjects: To evaluate the association of maternal antibiotic exposure during pregnancy on childhood BMI-z at 5 years, we conducted a retrospective cohort analysis. Read More

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http://dx.doi.org/10.1038/s41366-018-0316-6DOI Listing
January 2019
3 Reads

Mice exposed to maternal androgen excess and diet-induced obesity have altered phosphorylation of catechol-O-methyltransferase in the placenta and fetal liver.

Int J Obes (Lond) 2019 Jan 22. Epub 2019 Jan 22.

Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden.

Background/objectives: Maternal obesity together with androgen excess in mice negatively affects placental function and maternal and fetal liver function as demonstrated by increased triglyceride content with dysfunctional expression of enzymes and transcription factors involved in de novo lipogenesis and fat storage. To identify changes in molecular pathways that might promote diseases in adulthood, we performed a global proteomic analysis using a liquid-chromatography/mass-spectrometry system to investigate total and phosphorylated proteins in the placenta and fetal liver in a mouse model that combines maternal obesity with maternal androgen excess.

Methods: After ten weeks on a control diet (CD) or high fat/high sugar-diet, dams were mated with males fed the CD. Read More

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http://dx.doi.org/10.1038/s41366-018-0314-8DOI Listing
January 2019

Ileal transcriptome analysis in obese rats induced by high-fat diets and an adenoviral infection.

Int J Obes (Lond) 2019 Jan 22. Epub 2019 Jan 22.

Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.

Background: Obesity has become a worldwide epidemic affecting millions of people. Obesity and associated health consequences tend to be complicated by diverse causes and multi-systemic involvement. Previous studies have investigated obesity induced by a single factor, such as a high-fat diet (HF) of typical energy-dense food and infection by an adipogenic virus, such as a widely studied human adenovirus serotype 36 (Ad-36). Read More

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http://dx.doi.org/10.1038/s41366-019-0323-2DOI Listing
January 2019

Psychiatric adverse events and effects on mood with prolonged-release naltrexone/bupropion combination therapy: a pooled analysis.

Int J Obes (Lond) 2019 Jan 21. Epub 2019 Jan 21.

Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.

Background/objectives: Prolonged-release (PR) naltrexone 32 mg/bupropion 360 mg (NB) is approved for chronic weight management as an adjunct to reduced-calorie diet and increased physical activity. Central nervous system-active medications have the potential to affect mood; therefore, post hoc analysis of clinical trial data was conducted to evaluate psychiatric adverse events (PAEs) and effects on mood of NB therapy versus placebo.

Subjects/methods: Data were pooled from 5 prospective, double-blind, randomized, placebo-controlled clinical trials (duration range, 24-56 weeks) of NB in subjects with overweight or obesity. Read More

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http://dx.doi.org/10.1038/s41366-018-0302-zDOI Listing
January 2019
2 Reads

Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects.

Int J Obes (Lond) 2019 Jan 18. Epub 2019 Jan 18.

Centro de Excelencia en Medicina Traslacional, CEMT-BIOREN, Universidad de La Frontera, Temuco, Chile.

Background: Adenovirus 36 (Ad-36) has been associated to adiposity in animal and in vitro studies. Ad-36 seropositivity has also been reported to contribute to obesity risk in children and adult populations. We investigated the relationship of Ad-36 serology with obesity and metabolic parameters in a Chilean population. Read More

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http://dx.doi.org/10.1038/s41366-019-0321-4DOI Listing
January 2019
1 Read

The influence of 15-week exercise training on dietary patterns among young adults.

Int J Obes (Lond) 2019 Jan 18. Epub 2019 Jan 18.

Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX, USA.

Background/objectives: Little is currently known about how exercise may influence dietary patterns and/or food preferences. The present study aimed to examine the effect of a 15-week exercise training program on overall dietary patterns among young adults.

Subjects/methods: This study consisted of 2680 young adults drawn from the Training Intervention and Genetics of Exercise Response (TIGER) study. Read More

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http://dx.doi.org/10.1038/s41366-018-0299-3DOI Listing
January 2019
2 Reads

Activity energy expenditure is an independent predictor of energy intake in humans.

Int J Obes (Lond) 2019 Jan 18. Epub 2019 Jan 18.

School of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, UK.

Background: There is evidence that the energetic demand of metabolically active tissue is associated with day-to-day food intake (EI). However, the extent to which behavioural components of total daily energy expenditure (EE) such as activity energy expenditure (AEE) are also associated with EI is unknown. Therefore, the present study examined the cross-sectional associations between body composition, resting metabolic rate (RMR), AEE and EI. Read More

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http://www.nature.com/articles/s41366-018-0308-6
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http://dx.doi.org/10.1038/s41366-018-0308-6DOI Listing
January 2019
3 Reads

First incidence and associated factors of overweight and obesity from preschool to primary school: longitudinal analysis of a national cohort in Japan.

Int J Obes (Lond) 2019 Jan 18. Epub 2019 Jan 18.

National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.

Background/objectives: To assess longitudinal changes in the first incidence of overweight and obesity and associated factors from preschool to primary school age in Japan.

Subjects/methods: We obtained individual-level data from the "Longitudinal Survey of Newborns in the 21st Century" on children born in Japan in 2001. This analysis included 15,427 children (7951 boys and 7476 girls) with complete anthropometric data reported annually from age 42 months to 12 years. Read More

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http://dx.doi.org/10.1038/s41366-018-0307-7DOI Listing
January 2019
1 Read

In utero dioxin exposure and cardiometabolic risk in the Seveso Second Generation Study.

Int J Obes (Lond) 2019 Jan 18. Epub 2019 Jan 18.

Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA.

Background/objectives: In utero exposure to endocrine-disrupting compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) may alter risk of obesity and related metabolic disease later in life. We examined the relationship of prenatal exposure to TCDD with obesity and metabolic syndrome (MetS) in children born to a unique cohort of TCDD-exposed women resulting from a 1976 explosion in Seveso, Italy.

Subjects/methods: In 2014, nearly 40 years after the explosion, we enrolled 611 post-explosion offspring, 2 to 39 years of age, in the Seveso Second Generation Study. Read More

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http://dx.doi.org/10.1038/s41366-018-0306-8DOI Listing
January 2019
1 Read

A Delphi study to build consensus on the definition and use of big data in obesity research.

Int J Obes (Lond) 2019 Jan 17. Epub 2019 Jan 17.

School of Sport, Leeds Beckett University, LS6 3QQ, Leeds, UK.

Background: 'Big data' has great potential to help address the global health challenge of obesity. However, lack of clarity with regard to the definition of big data and frameworks for effectively using big data in the context of obesity research may be hindering progress. The aim of this study was to establish agreed approaches for the use of big data in obesity-related research. Read More

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http://dx.doi.org/10.1038/s41366-018-0313-9DOI Listing
January 2019
1 Read

Cognitive dietary restraint, disinhibition, and hunger are associated with 24-h energy expenditure.

Int J Obes (Lond) 2019 Jan 16. Epub 2019 Jan 16.

Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, 85016, USA.

Background: Higher energy expenditure (EE) is associated with greater food intake, possibly because the human body senses EE and modifies eating behaviors to regulate food intake and ultimately achieve energy balance. As eating behaviors are also influenced by social and cultural factors, any association between EE and eating behavior may differ between ethnicities and sexes.

Objective: To assess relationships between EE and eating behavior constructs of the Three-Factor Eating Questionnaire (TFEQ). Read More

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http://dx.doi.org/10.1038/s41366-018-0305-9DOI Listing
January 2019
1 Read

Increase of body mass index and waist circumference predicts development of metabolic syndrome criteria in apparently healthy individuals with 2 and 5 years follow-up.

Int J Obes (Lond) 2019 Jan 15. Epub 2019 Jan 15.

Internal Medicine Department "C", "D" &"E", The Tel Aviv-Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: The metabolic syndrome (MetS) is associated with overweight and abdominal obesity. Our aim was to use longitudinal measurements to provide clinically relevant information on the relative influence of changes in body mass index (BMI), waist circumference (WC), and weekly physical exercise duration on the development of each of the MetS components.

Methods: We analyzed data collected at the Tel-Aviv Medical Center Inflammation Survey (TAMCIS). Read More

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http://dx.doi.org/10.1038/s41366-018-0312-xDOI Listing
January 2019
1 Read

Deletion of translin (Tsn) induces robust adiposity and hepatic steatosis without impairing glucose tolerance.

Int J Obes (Lond) 2019 Jan 15. Epub 2019 Jan 15.

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Objective: Translin knockout (KO) mice display robust adiposity. Recent studies indicate that translin and its partner protein, trax, regulate the microRNA and ATM kinase signaling pathways, both of which have been implicated in regulating metabolism. In the course of characterizing the metabolic profile of these mice, we found that they display normal glucose tolerance despite their elevated adiposity. Read More

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http://www.nature.com/articles/s41366-018-0315-7
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http://dx.doi.org/10.1038/s41366-018-0315-7DOI Listing
January 2019
4 Reads

Physical education and leisure-time sport reduce overweight and obesity: a number needed to treat analysis.

Int J Obes (Lond) 2019 Jan 8. Epub 2019 Jan 8.

Faculty of Kinesiology, University of New Brunswick, Fredericton, Canada.

Background: School-based physical education (PE) and organised leisure-time sports participation (LTSP) represent important physical activity opportunities for children. We examined the preventive effect of increased PE as well as LTSP on overweight and obesity (OW/OB) in school children.

Methods: Longitudinal data from children attending 10 primary schools in the Danish municipality of Svendborg, comprising 6 intensive PE (270 min/week) and 4 control (90 min/week) schools were assessed. Read More

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http://dx.doi.org/10.1038/s41366-018-0300-1DOI Listing
January 2019

Associations of prenatal exposure to impaired glucose tolerance with eating in the absence of hunger in early adolescence.

Int J Obes (Lond) 2019 Jan 8. Epub 2019 Jan 8.

Division of Chronic Disease Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Objective: Exposure to impaired gestational glucose tolerance has been shown to have sex-specific associations with offspring obesity risk, perhaps by affecting the development of appetite regulation. We examined the extent to which prenatal exposure to impaired glucose tolerance was associated with eating in the absence of hunger (EAH) in early adolescent offspring, and in turn, whether EAH was cross-sectionally associated with body composition.

Methods: We included data from 1097 adolescents participating in Project Viva, a pre-birth longitudinal cohort. Read More

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http://www.nature.com/articles/s41366-018-0296-6
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http://dx.doi.org/10.1038/s41366-018-0296-6DOI Listing
January 2019
8 Reads

Maternal high-fat diet during suckling programs visceral adiposity and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 in offspring.

Int J Obes (Lond) 2019 Jan 8. Epub 2019 Jan 8.

Univ. Lille, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F-59000, Lille, France.

Objective: The lactation-suckling period is critical for white adipose tissue (WAT) development. Early postnatal nutrition influences later obesity risk but underlying mechanisms remain elusive. Here, we tested whether altered postnatal nutrition specifically during suckling impacts epigenetic regulation of key metabolic genes in WAT and alter long-term adiposity set point. Read More

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http://dx.doi.org/10.1038/s41366-018-0310-zDOI Listing
January 2019
9 Reads

High-fat feeding reprograms maternal energy metabolism and induces long-term postpartum obesity in mice.

Int J Obes (Lond) 2019 Jan 8. Epub 2019 Jan 8.

Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.

Background: Excessive gestational weight gain (EGWG) closely associates with postpartum obesity. However, the causal role of EGWG in postpartum obesity has not been experimentally verified. The objective of this study was to determine whether and how EGWG causes long-term postpartum obesity. Read More

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http://dx.doi.org/10.1038/s41366-018-0304-xDOI Listing
January 2019

A body shape index (ABSI) reflects body composition changes in response to testosterone treatment in obese men.

Int J Obes (Lond) 2019 Jan 8. Epub 2019 Jan 8.

Department of Medicine Austin Health, University of Melbourne, Heidelberg, VIC, Australia.

Background: Interventions such as testosterone treatment may change body composition and metabolic outcomes without substantial changes in weight and BMI.

Objectives: Using testosterone treatment as a paradigm, we hypothesized that a body shape index (ABSI) reflects body composition changes more accurately than traditional markers, such as weight, BMI and waist circumference.

Intervention: Secondary analysis of a 56-week RCT in 100 dieting obese men with low-normal testosterone receiving testosterone treatment or placebo, and subsequent off-treatment follow-up. Read More

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http://dx.doi.org/10.1038/s41366-018-0311-yDOI Listing
January 2019

Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood.

Int J Obes (Lond) 2019 Jan 8. Epub 2019 Jan 8.

NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Background: The early life environment may influence susceptibility to obesity and metabolic disease in later life through epigenetic processes. SLC6A4 is an important mediator of serotonin bioavailability, and has a key role in energy balance. We tested the hypothesis that methylation of the SLC6A4 gene predicts adiposity across the life course. Read More

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http://www.nature.com/articles/s41366-018-0254-3
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http://dx.doi.org/10.1038/s41366-018-0254-3DOI Listing
January 2019
7 Reads

Dietary weight loss intervention improves subclinical atherosclerosis and oxidative stress markers in leukocytes of obese humans.

Int J Obes (Lond) 2019 Jan 8. Epub 2019 Jan 8.

Service of Endocrinology and Nutrition, University Hospital Doctor Peset-FISABIO, Av. Gaspar Aguilar 90, 46017, Valencia, Spain.

Background: The relationship between caloric restriction-mediated weight loss and the generation of ROS and its effects on atherosclerotic markers in obesity is not fully understood. Therefore, we set out to investigate whether dietary weight loss intervention improves markers of oxidative stress in leukocytes and subclinical parameters of atherosclerosis.

Subjects And Methods: This was an interventional study of 59 obese subjects (BMI > 35 kg/m) who underwent 6 months of dietary therapy, including a 6-week very-low-calorie diet (VLCD) followed by an 18-week low-calorie diet (LCD). Read More

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http://dx.doi.org/10.1038/s41366-018-0309-5DOI Listing
January 2019
1 Read

The joint associations of weight status and physical activity with mobility disability: The NIH-AARP Diet and Health Study.

Int J Obes (Lond) 2018 Dec 21. Epub 2018 Dec 21.

Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Background/objectives: The purpose of this study was to determine the joint associations of weight status and physical activity with mobility disability in older men and women.

Subjects/methods: We analyzed prospective data from 135,220 participants in the NIH-AARP Diet and Health Study between 1995-1996 and 2004-2005.

Methods: Height and weight, as well as light- and moderate-to-vigorous-intensity physical activity typical of the past 10 years (h/week) were self-reported at baseline, and body mass index (BMI: kg/m) was categorized into normal weight (BMI 18 to <25 kg/m); overweight (BMI 25 to <30 kg/m); and obese (BMI ≥ 30 kg/m). Read More

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http://www.nature.com/articles/s41366-018-0294-8
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http://dx.doi.org/10.1038/s41366-018-0294-8DOI Listing
December 2018
5 Reads

Body mass index and use and costs of primary care services among women aged 55-79 years in England: a cohort and linked data study.

Int J Obes (Lond) 2018 Dec 19. Epub 2018 Dec 19.

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, USA.

Background: Excess weight is associated with poor health and increased healthcare costs. There are no reliable data describing the association between BMI and the use and costs of primary care services in the United Kingdom.

Methods: Among 69,440 participants in the Million Women Study with primary care records in the Clinical Practice Research Datalink between April 2006 (mean age 64 years) and March 2014, the annual rates and costs of their primary care consultations, prescription medications, and diagnostic and monitoring tests were estimated in relation to their self-reported body mass index (BMI) at recruitment in 1996-2001 (mean age 56 years). Read More

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http://dx.doi.org/10.1038/s41366-018-0288-6DOI Listing
December 2018
1 Read

Spatiotemporal predictions of obesity prevalence in Chinese children and adolescents: based on analyses of obesogenic environmental variability and Bayesian model.

Int J Obes (Lond) 2018 Dec 19. Epub 2018 Dec 19.

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No. 29 Nanwei Road, Xicheng District, Beijing, 100050, China.

Objective: To find variations in Chinese obesogenic environmental priorities from 2000 to 2011, predict spatiotemporal distribution of obesity prevalence aged 7-17 years in 31 provinces, and provide foundations for policy-makers to reduce obesity in children and adolescents.

Methods: Based on data examination of provincial obesity prevalence aged 7-17 years from three rounds of China Health and Nutrition Surveys (in 9 [2000], 9 [2006], and 12 [2011] provinces) and corresponding years' environments in 31 provinces from China Statistical Yearbooks and other sources, 12 predictors were selected. We used 30 surveyed provinces in three rounds as training samples to fit three analytic models with partial least-square regressions and prioritized predictors by variable importance projection to find variations. Read More

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http://dx.doi.org/10.1038/s41366-018-0301-0DOI Listing
December 2018
1 Read

"IGT-like" status in normoglucose tolerant obese children and adolescents: the additive role of glucose profile morphology and 2-hours glucose concentration during the oral glucose tolerance test.

Int J Obes (Lond) 2018 Dec 19. Epub 2018 Dec 19.

Pediatric Diabetes and Metabolic Disorders Unit, University Hospital of Verona, Verona, Italy.

Objective: To assess whether combining glucose shape and 2-h glucose concentration during an oral glucose tolerance test (OGTT) may help identifying normal glucose tolerant obese children/adolescents with an impaired glucose tolerant (IGT)-like metabolic profile in term of insulin sensitivity (Matsuda index) and β-cell function (disposition index: DI).

Subjects, Methods, And Main Outcome Measure: In total, 654 non-diabetic obese children/adolescents underwent a 2 h OGTT. The whole population was classified according to 2-hour plasma glucose ( < 100, 100-119, 120-139, 140-200 mg/dL) and glucose shape (monophasic or biphasic). Read More

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http://dx.doi.org/10.1038/s41366-018-0297-5DOI Listing
December 2018
1 Read

Subcutaneous fat mass in infancy and abdominal, pericardial and liver fat assessed by Magnetic Resonance Imaging at the age of 10 years.

Int J Obes (Lond) 2019 Feb 19;43(2):392-401. Epub 2018 Dec 19.

The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.

Background/objectives: Fat mass development in infancy contributes to later adiposity, but its relation to ectopic fat depots is unknown. We examined the associations of infant subcutaneous fat with childhood general and organ-specific fat.

Subjects/methods: Among 593 children from a population-based prospective cohort study, we obtained total subcutaneous fat mass (as sum of biceps, triceps, suprailiacal, and subscapular skinfolds thickness), central-to-total subcutaneous fat ratio (sum of suprailiacal and subscapular skinfold thickness/total subcutaneous fat) at 1. Read More

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http://dx.doi.org/10.1038/s41366-018-0287-7DOI Listing
February 2019
2 Reads

Maternal obesity leads to long-term altered levels of plasma ceramides in the offspring as revealed by a longitudinal lipidomic study in children.

Int J Obes (Lond) 2018 Dec 19. Epub 2018 Dec 19.

INRA, UMR1280 Physiologie des Adaptations Nutritionnelles, Université de Nantes, Nantes Atlantique Université, Nantes, France.

Background/objectives: Maternal obesity is associated with increased risk of obesity and other symptoms of the metabolic syndrome in the offspring. Nevertheless, the molecular mechanisms and cellular factors underlying this enhanced disease susceptibility remain to be determined. Here, we aimed at identifying changes in plasma lipids in offspring of obese mothers that might underpin, and serve as early biomarkers of, their enhanced metabolic disease risk. Read More

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http://www.nature.com/articles/s41366-018-0291-y
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http://dx.doi.org/10.1038/s41366-018-0291-yDOI Listing
December 2018
4 Reads

Comparison of salivary proteome of children with different sensitivities for bitter and sweet tastes: association with body mass index.

Int J Obes (Lond) 2018 Dec 19. Epub 2018 Dec 19.

Institute of Mediterranean Agricultural and Environmental Sciences (ICAAM), University of Évora, Évora, Portugal.

Background/objectives: Oral sensorial perception is a key aspect in food choices and knowing the mechanisms modulating such perception is of major importance in the context of child obesity, which is reaching high rates in Mediterranean countries. Salivary proteome has been linked to taste sensitivity in adults. The aim of this study was to search for differences in salivary proteomes of children with different bitter or sweet taste sensitivities and to assess if these potential differences are associated with their body mass index percentile (BMI percentile). Read More

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http://dx.doi.org/10.1038/s41366-018-0289-5DOI Listing
December 2018
1 Read

Validity of multi-frequency bioelectric impedance methods to measure body composition in obese patients: a systematic review.

Int J Obes (Lond) 2018 Dec 19. Epub 2018 Dec 19.

Department of Rehabilitation, Nutrition and Sport, School of Allied Health, La Trobe University, Victoria, Australia.

Objective: Excessive lean tissue loss following bariatric surgery may pose serious metabolic consequences. Accurate methods to assess body composition following bariatric surgery are required. This review aimed to investigate if multi-frequency bioelectric impedance (MF-BI) is a valid tool to determine body composition in obese patients. Read More

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http://dx.doi.org/10.1038/s41366-018-0285-9DOI Listing
December 2018
1 Read

Noise-induced sleep disruption increases weight gain and decreases energy metabolism in female rats.

Int J Obes (Lond) 2018 Dec 19. Epub 2018 Dec 19.

Department of Nutritional Sciences, University of Arizona, Tucson, AZ, USA.

Background/objectives: Inadequate sleep increases obesity and environmental noise contributes to poor sleep. However, women may be more vulnerable to noise and hence more susceptible to sleep disruption-induced weight gain than men. In male rats, exposure to environmental (i. Read More

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http://dx.doi.org/10.1038/s41366-018-0293-9DOI Listing
December 2018
2 Reads

Pathways to eating in children and adolescents with obesity.

Int J Obes (Lond) 2018 Dec 19. Epub 2018 Dec 19.

Credit Valley Hospital, Toronto, ON, Canada.

Background: Paediatric obesity management remains generalised to dietary and exercise modifications with an underappreciation for the contributions of eating behaviours and appetitive traits in the development of obesity.

Objectives: To determine whether treatment-seeking children and adolescents with obesity cluster into phenotypes based on known eating behaviours and appetitive traits ("eating correlates") and how socio-demographic and clinical characteristics associate with different phenotypes.

Methods: A cross-sectional, multi-centre questionnaire was administered between November 2015 and March 2017 examining correlates of eating in children and adolescents attending weight-management programmes in Canada. Read More

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http://dx.doi.org/10.1038/s41366-018-0271-2DOI Listing
December 2018
2 Reads