8,011 results match your criteria International Journal of Obesity[Journal]


Assessing causality in the association between attention-deficit/hyperactivity disorder and obesity: a Mendelian randomization study.

Int J Obes (Lond) 2019 Apr 18. Epub 2019 Apr 18.

Postgraduate Program in Epidemiology, Universidade Federal de Pelotas, Pelotas, Brazil.

Background/objectives: Attention-deficit hyperactivity disorder (ADHD), one of the most common neurodevelopmental disorders in childhood and adolescence, is associated with obesity in observational studies. However, it is unclear whether ADHD contributes to, results from or is merely correlated with obesity. This study evaluates the presence and direction of a causal effect between ADHD and obesity. Read More

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http://dx.doi.org/10.1038/s41366-019-0346-8DOI Listing

The relationship between maternal body mass index and pregnancy outcomes in twin compared with singleton pregnancies.

Int J Obes (Lond) 2019 Apr 16. Epub 2019 Apr 16.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.

Objecive: Women with twins have an a priori increased risk for many of the complications associated with maternal obesity. Thus, the impact of maternal obesity in twins may differ from that reported in singletons. In addition, given the increased metabolic demands in twin pregnancies, the impact of maternal underweight may be greater in twin compared with singleton gestations. Read More

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http://dx.doi.org/10.1038/s41366-019-0362-8DOI Listing
April 2019
1 Read

Effects of bariatric surgery on telomere length and T-cell aging.

Int J Obes (Lond) 2019 Apr 12. Epub 2019 Apr 12.

Department of Internal Medicine, Section Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, The Netherlands.

Background: Obesity adversely affects health and is associated with subclinical systemic inflammation and features of accelerated aging, including the T-cell immune system. The presence of metabolic syndrome (MetS) may accelerate, while bariatric surgery might reverse these phenomena. To examine the effects of MetS and bariatric surgery on T-cell aging, we measured relative telomere length (RTL) and T-cell differentiation status in obese patients before and after bariatric surgery. Read More

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http://www.nature.com/articles/s41366-019-0351-y
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http://dx.doi.org/10.1038/s41366-019-0351-yDOI Listing
April 2019
4 Reads

Attentional bias and response inhibition in severe obesity with food disinhibition: a study of P300 and N200 event-related potential.

Int J Obes (Lond) 2019 Apr 9. Epub 2019 Apr 9.

Centre Intégré de l'Obésité Rhône-Alpes; Fédération Hospitalo-Universitaire DO-iT, Service Endocrinologie-Diabète-Nutrition, Université de Lyon, Groupement Hospitalier Sud, Hospices Civils de Lyon, Lyon, France.

Background/objective: In obesity there is growing evidence for common mechanism between food intake regulation and substance use disorders, especially more attentional bias and less cognitive control. In the present study we investigated whether severely obese subjects with or without disordered eating exhibit electroencephalographic (EEG) event-related potential (ERP) modifications as observed in substance abusers.

Subjects/methods: A total of 90 women were included; 30 in the normal-weight (NW) group (18. Read More

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http://dx.doi.org/10.1038/s41366-019-0360-xDOI Listing
April 2019
5.004 Impact Factor

Salience network connectivity is reduced by a meal and influenced by genetic background and hypothalamic gliosis.

Int J Obes (Lond) 2019 Apr 9. Epub 2019 Apr 9.

Department of Medicine, University of Washington, Seattle, WA, USA.

Background/objectives: The salience network (SN) comprises brain regions that evaluate cues in the external environment in light of internal signals. We examined the SN response to meal intake and potential genetic and acquired influences on SN function.

Subjects/methods: Monozygotic (MZ; 40 pairs) and dizygotic (15 pairs) twins had body composition and plasma metabolic profile evaluated (glucose, insulin, leptin, ghrelin, and GLP-1). Read More

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http://dx.doi.org/10.1038/s41366-019-0361-9DOI Listing

Use of high-fat diets to study rodent obesity as a model of human obesity.

Authors:
John R Speakman

Int J Obes (Lond) 2019 Apr 9. Epub 2019 Apr 9.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, Center for Developmental Biology No. 1 West Beichen Road, Chaoyang District, Beijing, 100101, China.

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http://dx.doi.org/10.1038/s41366-019-0363-7DOI Listing

Trends in height, weight, BMI, skinfolds, and measures of overweight and obesity from 1979 through 1999 among American Indian Youth: The Akwesasne Mohawk.

Int J Obes (Lond) 2019 Apr 3. Epub 2019 Apr 3.

Department of Epidemiology and Biostatistics, University at Albany, Albany, NY, 12222, USA.

Background/objectives: Information on recent changes in overweight, obesity, and adiposity among American Indians is scarce. To assess changes in size and adiposity among American Indian youth, data from two samples of Akwesasne Mohawk youth, were compared.

Subjects/methods: Both project 1, conducted in 1979 (n = 75) and Project 2, conducted between 1996 and 1999 (n = 206), sampled youth 10-14 years of age from the Akwesasne Mohawk Reservation (aka St. Read More

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http://dx.doi.org/10.1038/s41366-019-0349-5DOI Listing
April 2019
1 Read

Identification of a 1p21 independent functional variant for abdominal obesity.

Int J Obes (Lond) 2019 Apr 3. Epub 2019 Apr 3.

Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou, China.

Objectives: Aiming to uncover the genetic basis of abdominal obesity, we performed a genome-wide association study (GWAS) meta-analysis of trunk fat mass adjusted by trunk lean mass (TFM) and followed by a series of functional investigations.

Subjects: A total of 11,569 subjects from six samples were included into the GWAS meta-analysis.

Methods: Meta-analysis was performed by a weighted fixed-effects model. Read More

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http://dx.doi.org/10.1038/s41366-019-0350-zDOI Listing
April 2019
1 Read
5.004 Impact Factor

Aryl hydrocarbon receptor agonist indigo protects against obesity-related insulin resistance through modulation of intestinal and metabolic tissue immunity.

Int J Obes (Lond) 2019 Apr 3. Epub 2019 Apr 3.

Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network, 101 College Street, Toronto, ON, M5G 1L7, Canada.

Background/objectives: Low-grade chronic inflammation in visceral adipose tissue and the intestines are important drivers of obesity associated insulin resistance. Bioactive compounds derived from plants are an important source of potential novel therapies for the treatment of chronic diseases. In search for new immune based treatments of obesity associated insulin resistance, we screened for tissue relevant anti-inflammatory properties in 20 plant-based extracts. Read More

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http://dx.doi.org/10.1038/s41366-019-0340-1DOI Listing

Estimating energy expenditure from wrist and thigh accelerometry in free-living adults: a doubly labelled water study.

Int J Obes (Lond) 2019 Apr 2. Epub 2019 Apr 2.

MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

Background: Many large studies have implemented wrist or thigh accelerometry to capture physical activity, but the accuracy of these measurements to infer activity energy expenditure (AEE) and consequently total energy expenditure (TEE) has not been demonstrated. The purpose of this study was to assess the validity of acceleration intensity at wrist and thigh sites as estimates of AEE and TEE under free-living conditions using a gold-standard criterion.

Methods: Measurements for 193 UK adults (105 men, 88 women, aged 40-66 years, BMI 20. Read More

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http://dx.doi.org/10.1038/s41366-019-0352-xDOI Listing
April 2019
1 Read

Correction: Interventions for treating children and adolescents with overweight and obesity: an overview of Cochrane reviews.

Int J Obes (Lond) 2019 Apr 2. Epub 2019 Apr 2.

World Health Organization, Geneva, Switzerland.

This paper was originally published under a standard licence. This has now been amended to a CC BY licence in the PDF and HTML. Read More

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http://www.nature.com/articles/s41366-019-0358-4
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http://dx.doi.org/10.1038/s41366-019-0358-4DOI Listing
April 2019
3 Reads
5.004 Impact Factor

Sex-specific longitudinal associations of screen viewing time in children at 2-3 years with adiposity at 3-5 years.

Int J Obes (Lond) 2019 Apr 2. Epub 2019 Apr 2.

Saw Swee Hock School of Public Health, National University of, Singapore, Singapore.

Objectives: Screen-viewing in late childhood has been associated with adiposity and blood pressure (BP), but evidence is lacking at younger ages. To investigate the prospective associations of total and device-specific screen-viewing at age 2-3 years with BMI, sum of skinfold thicknesses and BP among Singaporean children at age 3-5 years.

Methods: As part of the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort, mothers/caregivers reported the time per day their 2 and 3-year-old children watched/used television, handheld devices and computers. Read More

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http://dx.doi.org/10.1038/s41366-019-0344-xDOI Listing
April 2019
2 Reads

The relationship between body mass index and disability-free survival in elderly Japanese: the Ohsaki Cohort 2006 Study.

Int J Obes (Lond) 2019 Apr 2. Epub 2019 Apr 2.

Division of Epidemiology, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Miyagi, Japan.

Background: The relationship between body mass index (BMI) and disability-free survival (DFS) remains unclear.

Methods: We conducted a 10-year prospective cohort study of 12,666 Japanese individuals aged ≥ 65 y. Information on BMI and lifestyle factors was collected via a questionnaire in 2006. Read More

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http://dx.doi.org/10.1038/s41366-019-0359-3DOI Listing
April 2019
2 Reads

Association of accelerated body mass index gain with repeated measures of blood pressure in early childhood.

Int J Obes (Lond) 2019 Apr 2. Epub 2019 Apr 2.

Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada.

Background/objectives: We examined the association for rates of age- and sex-standardized body mass index (zBMI) gain between 0-3, 3-18, and 18-36 months with BP in children at 36-72 months of age.

Methods: We collected repeated measures of zBMI and BP in 2502 children. zBMI was calculated using the World Health Organization standards. Read More

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http://dx.doi.org/10.1038/s41366-019-0345-9DOI Listing

Effects of liraglutide on appetite, food preoccupation, and food liking: results of a randomized controlled trial.

Int J Obes (Lond) 2019 Mar 29. Epub 2019 Mar 29.

Department of Psychiatry, Center for Weight and Eating Disorders, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Background: Some weight loss medications, including liraglutide 3.0 mg, are thought to facilitate weight loss by improving appetite control. However, no studies have evaluated their long-term appetitive effects. Read More

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http://dx.doi.org/10.1038/s41366-019-0348-6DOI Listing
March 2019
1 Read

Comparison of the associations between non-traditional and traditional indices of adiposity and cardiovascular mortality: an observational study of one million person-years of follow-up.

Int J Obes (Lond) 2019 Mar 29. Epub 2019 Mar 29.

Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.

Background/objective: The most widely used adiposity index, body mass index (BMI), is not optimal to evaluate cardiovascular (CV) risk associated with overweight and obesity. We aimed to explore the association between traditional and non-traditional adiposity indices and CV mortality, and compare their discriminative ability for CV death.

Methods: We studied participants (age 19-79 years, BMI ≥18. Read More

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http://dx.doi.org/10.1038/s41366-019-0353-9DOI Listing
March 2019
1 Read

Alternative waist-to-height ratios associated with risk biomarkers in youth with diabetes: comparative models in the SEARCH for Diabetes in Youth Study.

Int J Obes (Lond) 2019 Mar 29. Epub 2019 Mar 29.

Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background/objectives: The waist-to-height ratio (WHtR) estimates cardiometabolic risk in youth without need for growth charts by sex and age. Questions remain about whether waist circumference measured per protocol of the National Health and Nutrition Examination Survey (WHtR) or World Health Organization (WHtR) can better predict blood pressures and lipid parameters in youth.

Participants/methods: WHtR was measured under both anthropometric protocols among participants in the SEARCH Study, who were recently diagnosed with diabetes (ages 5-19 years; N = 2 773). Read More

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http://dx.doi.org/10.1038/s41366-019-0354-8DOI Listing

Heterozygous rare genetic variants in non-syndromic early-onset obesity.

Int J Obes (Lond) 2019 Mar 29. Epub 2019 Mar 29.

Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Instituto de Investigación La Princesa, Universidad Autónoma de Madrid, Department of Pediatrics, Avenida Menéndez Pelayo, 65, 28009, Madrid, Spain.

Background: Obesity is a very heterogeneous disorder at both the clinical and molecular levels and with high heritability. Several monogenic forms and genes with strong effects have been identified for non-syndromic severe obesity. Novel therapeutic interventions are in development for some genetic forms, emphasizing the importance of determining genetic contributions. Read More

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http://dx.doi.org/10.1038/s41366-019-0357-5DOI Listing
March 2019
1 Read

Day-to-day regularity in breakfast consumption is associated with weight status in a prospective cohort of women.

Int J Obes (Lond) 2019 Mar 29. Epub 2019 Mar 29.

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, USA.

Background: Evidence suggests that regular eating patterns (i.e., consistent day-to-day frequency and timing of consumption) may be favorable with respect to weight status, and breakfast may be a particularly important meal for weight maintenance. Read More

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http://dx.doi.org/10.1038/s41366-019-0356-6DOI Listing

Effects of imidazoline-like drugs on liver and adipose tissues, and their role in preventing obesity and associated cardio-metabolic disorders.

Int J Obes (Lond) 2019 Mar 29. Epub 2019 Mar 29.

Laboratoire de Pharmacologie et Toxicologie NeuroCardiovasculaire (LPTNC) - EA7296, Faculté de Médecine, Fédération de Médecine Translationnelle, Université de Strasbourg, Strasbourg, France.

Background/objectives: We previously observed that selective agonists of the sympatho-inhibitory I imidazoline receptors (LNP ligands) have favorable effects on several cardiovascular and metabolic disorders defining the metabolic syndrome, including body weight. The objectives of this study were to explore the effects of LNPs on adiposity and the mechanisms involved, and to evaluate their impact on metabolic homeostasis.

Methods: Young Zucker fa/fa rats were treated with LNP599 (10 mg/kg/day) for 12 weeks. Read More

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http://dx.doi.org/10.1038/s41366-019-0342-zDOI Listing
March 2019
3 Reads

The CSF1 receptor inhibitor pexidartinib (PLX3397) reduces tissue macrophage levels without affecting glucose homeostasis in mice.

Int J Obes (Lond) 2019 Mar 29. Epub 2019 Mar 29.

Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.

Background And Objectives: Excessive adipose tissue macrophage accumulation in obesity has been implicated in mediating inflammatory responses that impair glucose homeostasis and promote insulin resistance. Colony-stimulating factor 1 (CSF1) controls macrophage differentiation, and here we sought to determine the effect of a CSF1 receptor inhibitor, PLX3397, on adipose tissue macrophage levels and understand the impact on glucose homeostasis in mice.

Methods: A Ten-week-old mice were fed a chow or high-fat diet for 10 weeks and then treated with PLX3397 via oral gavage (50 mg/kg) every second day for 3 weeks, with subsequent monitoring of glucose tolerance, insulin sensitivity and assessment of adipose tissue immune cells. Read More

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http://dx.doi.org/10.1038/s41366-019-0355-7DOI Listing
March 2019
2 Reads
5.004 Impact Factor

Relationships between circulating 25(OH) vitamin D, leptin levels and visceral adipose tissue volume: results from a 1-year lifestyle intervention program in men with visceral obesity.

Int J Obes (Lond) 2019 Mar 29. Epub 2019 Mar 29.

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Québec, QC, Canada.

Background/objectives: Obesity has been associated with elevated leptinemia and vitamin D deficiency. To date, whether there is an association between vitamin D and leptin levels independent from adiposity remains uncertain. Our objective was to investigate the associations between changes in 25(OH) vitamin D levels, changes in adiposity variables, and changes in leptin levels produced by a 1-year lifestyle intervention program. Read More

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http://dx.doi.org/10.1038/s41366-019-0347-7DOI Listing

Cost-effectiveness of community-based childhood obesity prevention interventions in Australia.

Int J Obes (Lond) 2019 Mar 29. Epub 2019 Mar 29.

Deakin Health Economics, Institute for Health Transformation, Faculty of Health, Deakin University, Geelong, VIC, Australia.

Objectives: The objective of this study is to examine, from a limited societal perspective, the cost-effectiveness of community-based obesity prevention interventions (CBIs)-defined as a programme of community-level strategies to promote healthy eating and physical activity for Australian children (aged 5-18 years).

Methods: The effectiveness of CBIs was determined by undertaking a literature review and meta-analysis. Commonly implemented strategies to increase physical activity and improve nutrition were costed (in 2010 Australian dollars) to determine the average cost of a generic programme. Read More

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http://dx.doi.org/10.1038/s41366-019-0341-0DOI Listing
March 2019
2 Reads

Correction: Data visualisation to support obesity policy: case studies of data tools for planning and transport policy in the UK.

Int J Obes (Lond) 2019 Mar 6. Epub 2019 Mar 6.

UKCRC Centre for Diet and Activity Research (CEDAR), MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.

The financial support for this Article was not fully acknowledged. The Acknowledgements should have included the following: "This work was undertaken by the Centre for Diet and Activity Research (CEDAR), a UK Clinical Research Collaboration (UKCRC) Public Health Research Centre of Excellence. Funding from the British Heart Foundation, Cancer Research UK, Economic and Social Research Council, Medical Research Council, the National Institute for Health Research [Grant Number ES/G007462/1], and the Wellcome Trust [Grant Number 087636/Z/08/Z], under the auspices of the UK Clinical Research Collaboration, is gratefully acknowledged. Read More

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http://dx.doi.org/10.1038/s41366-019-0335-yDOI Listing
March 2019
1 Read

Associations between inhibitory control, eating behaviours and adiposity in 6-year-old children.

Int J Obes (Lond) 2019 Mar 28. Epub 2019 Mar 28.

Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), National University Health System, Singapore, Singapore.

Background: Lower inhibitory control has been associated with obesity. One prediction is that lower inhibitory control underlies eating behaviours that promote increased energy intakes. This study examined the relationships between children's inhibitory control measured using the Stop Signal Task (SST), body composition and eating behaviours, which included self-served portion size, number of servings, eating rate, and energy intake at lunch and in an eating in the absence of hunger (EAH) task. Read More

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http://dx.doi.org/10.1038/s41366-019-0343-yDOI Listing

Breastfeeding and cardiometabolic markers at age 12: a population-based birth cohort study.

Int J Obes (Lond) 2019 Mar 18. Epub 2019 Mar 18.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: There is growing evidence for a protective effect of breastfeeding against overweight and diabetes. It is less clear though, whether breastfed infants also have a more favorable cardiometabolic profile in childhood.

Objective: We investigated whether children who were breastfed in infancy had more favorable cardiometabolic markers at 12 years of age than children who were never breastfed and received formula milk instead, and whether associations depended on the duration of breastfeeding. Read More

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http://dx.doi.org/10.1038/s41366-018-0317-5DOI Listing

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort.

Int J Obes (Lond) 2019 Mar 6. Epub 2019 Mar 6.

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.

Background: The relationship between obesity and adverse health is well established, but little is known about the contribution of DNA methylation to obesity-related health outcomes. This study tests associations between an epigenetic score for body mass index (BMI) and health-related, cognitive, psychosocial and lifestyle outcomes in the Lothian Birth Cohort 1936. This study also tests whether these associations are independent of phenotypic BMI. Read More

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http://dx.doi.org/10.1038/s41366-018-0262-3DOI Listing
March 2019
3 Reads

Correction: Effect of intermittent compared to continuous energy restriction on weight loss and weight maintenance after 12 months in healthy overweight or obese adults.

Int J Obes (Lond) 2019 Apr;43(4):942

Division of Health Sciences, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.

Table 4 is still missing from both versions. It was labeled Table 3 in the first version but a reviewer wanted an extra table in the methods which became Table 1. Read More

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http://dx.doi.org/10.1038/s41366-019-0339-7DOI Listing
April 2019
2 Reads

Publisher Correction: Pathways to eating in children and adolescents with obesity.

Int J Obes (Lond) 2019 Mar;43(3):638

Institute of Medical Science, University of Toronto, Toronto, Canada.

In the original version of this Article the following were listed as authors; however, they should have only been referred to in the Acknowledgments section and not listed in this way. Read More

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http://dx.doi.org/10.1038/s41366-019-0338-8DOI Listing

Adipose tissue loss and lipodystrophy in xylosyltransferase II deficient mice.

Int J Obes (Lond) 2019 Feb 18. Epub 2019 Feb 18.

Department of Physiological Sciences, Oklahoma State University, Stillwater, OK, 74078, USA.

Background/objectives: The cellular and extracellular matrix (ECM) interactions that regulate adipose tissue homeostasis are incompletely understood. Proteoglycans (PGs) and their sulfated glycosaminoglycans (GAGs) provide spatial and temporal signals for ECM organization and interactions with resident cells by impacting growth factor and cytokine activity. Therefore, PGs and their GAGs could be significant to adipose tissue homeostasis. Read More

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http://dx.doi.org/10.1038/s41366-019-0324-1DOI Listing
February 2019
1 Read
5.004 Impact Factor

Author Correction: Data visualisation to support obesity policy: case studies of data tools for planning and transport policy in the UK.

Int J Obes (Lond) 2019 Mar;43(3):639

UKCRC Centre for Diet and Activity Research (CEDAR), MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.

In the original version of this Article the following funding details were omitted from the Acknowledgements section. Read More

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http://dx.doi.org/10.1038/s41366-019-0337-9DOI Listing
March 2019
2 Reads

Metabolic improvement in obese patients after duodenal-jejunal exclusion is associated with intestinal microbiota composition changes.

Int J Obes (Lond) 2019 Feb 14. Epub 2019 Feb 14.

Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

Background: Intestinal microbiota have been suggested to play an important role in the pathogenesis of obesity and type 2 diabetes. Bariatric surgery improves both conditions and has been associated with changes in intestinal microbiota composition. We investigated the effect of a nonsurgical bariatric technique on intestinal microbiota composition in relation to metabolic improvement. Read More

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http://dx.doi.org/10.1038/s41366-019-0336-xDOI Listing
February 2019

Does birth mode modify associations of maternal pre-pregnancy BMI and gestational weight gain with the infant gut microbiome?

Int J Obes (Lond) 2019 Feb 14. Epub 2019 Feb 14.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background: Mother-to-newborn transmission of obesity-associated microbiota may be modified by birth mode (vaginal vs. Cesarean delivery). Prospective data to test this hypothesis are still sparse. Read More

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http://dx.doi.org/10.1038/s41366-018-0273-0DOI Listing
February 2019
2 Reads

The effects of a teaching intervention on weight bias among kinesiology undergraduate students.

Int J Obes (Lond) 2019 Feb 12. Epub 2019 Feb 12.

Department of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX, USA.

Objectives: Weight bias is present among kinesiology professionals and this may cause a significant negative impact on their clients with obesity. Thus, our objective was to test if learning about uncontrollable cause of obesity and about weight bias would reduce explicit and implicit weight bias among kinesiology undergraduate students compared to the traditional curriculum which is more focused on controllable causes of weight gain.

Methods: We recruited undergraduates from two classes of the same kinesiology major course taught by the same instructor. Read More

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http://dx.doi.org/10.1038/s41366-019-0325-0DOI Listing
February 2019
2 Reads

Medical marijuana-an obesity problem or opportunity?

Int J Obes (Lond) 2019 Apr 12;43(4):761-762. Epub 2019 Feb 12.

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.

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http://dx.doi.org/10.1038/s41366-019-0334-zDOI Listing

Disparities in childhood overweight and obesity by income in the United States: an epidemiological examination using three nationally representative datasets.

Int J Obes (Lond) 2019 Feb 4. Epub 2019 Feb 4.

Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Public Health Research Center, 921 Assembly St. rm 130, Columbia, SC, 29201, USA.

Background/objectives: Overweight and obesity (OWOB) is a global epidemic. Adults and adolescents from low-income households are at higher risk to be OWOB. This study examined the relationship between income and OWOB prevalence in children and adolescents (518 years) in the United States (US) within and across race/ethnicities, and changes in this relationship from 1971 to 2014. Read More

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http://dx.doi.org/10.1038/s41366-019-0331-2DOI Listing
February 2019
2 Reads
5.004 Impact Factor

Childhood growth patterns and cardiovascular autonomic modulation in midlife: Northern Finland 1966 Birth Cohort Study.

Int J Obes (Lond) 2019 Feb 4. Epub 2019 Feb 4.

Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

Objectives: To test the hypothesis that age and body mass index (BMI) at BMI peak during infancy and at BMI rebound in childhood are related to cardiovascular autonomic modulation in adulthood.

Methods: At the age of 46 years, a sample (n = 5861) of the participants of the Northern Finland Birth Cohort 1966 took part in follow-up examinations. Heart rate variability (HRV), baroreflex sensitivity (BRS) and low-frequency oscillations of systolic blood pressure (LF) were measured during sympathetic stimulus by standing. Read More

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http://dx.doi.org/10.1038/s41366-019-0333-0DOI Listing
February 2019
5 Reads

Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice.

Int J Obes (Lond) 2019 Feb 4. Epub 2019 Feb 4.

College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture; Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, 100083, Beijing, China.

Objective: Resveratrol (RSV) is a natural polyphenol with putative anti-obesity effects; however, its mechanisms of action remain unclear due to its low bioavailability. Microbial functions in the physiology result from the microbiota-host coevolution has profoundly affected host metabolism. Here, we sought to determine how beneficial microbiome caused by RSV interventions affects antiobesity. Read More

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http://www.nature.com/articles/s41366-019-0332-1
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http://dx.doi.org/10.1038/s41366-019-0332-1DOI Listing
February 2019
19 Reads

Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS.

Int J Obes (Lond) 2019 Feb 4. Epub 2019 Feb 4.

Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.

Background: Adiposity rebound (AR), the second BMI rise in childhood at around the age of 6 years, is associated with obesity and metabolic alteration in later life. Given that polycystic ovary syndrome (PCOS) has a strong metabolic component, early life growth patterns could reveal a risk of PCOS. Thus, we aimed to investigate the associations between age at AR and PCOS diagnosis and BMI later in life. Read More

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http://dx.doi.org/10.1038/s41366-019-0318-zDOI Listing
February 2019
3 Reads

Unlike calorie restriction, Roux-en-Y gastric bypass surgery does not increase hypothalamic AgRP and NPY in mice on a high-fat diet.

Int J Obes (Lond) 2019 Feb 4. Epub 2019 Feb 4.

Department of Nutritional Sciences, College of Human Sciences, Texas Tech University, Lubbock, TX, 79409, USA.

Objectives: Dieting often fails because weight loss triggers strong counter-regulatory biological responses such as increased hunger and hypometabolism that are thought to be critically dependent on the master fuel sensor in the mediobasal hypothalamus (MBH). Because prolonged starvation has been shown to increase AgRP and NPY, the expression level of these two orexigenic genes has been taken as an experimental readout for the presence or absence of hunger. Roux-en-Y gastric bypass (RYGB) surgery leads to a significant weight loss without inducing the associated hunger, indicating possible changes in hypothalamic neuropeptides and/or signaling. Read More

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http://dx.doi.org/10.1038/s41366-019-0328-xDOI Listing
February 2019

Joint associations between weekday and weekend physical activity or sedentary time and childhood obesity.

Int J Obes (Lond) 2019 Apr 31;43(4):691-700. Epub 2019 Jan 31.

Pennington Biomedical Research Center, Baton Rouge, LA, USA.

Objective: To evaluate the single and joint associations of objectively measured moderate-to-vigorous physical activity (MVPA) and sedentary time on week and weekend days with obesity in children from 12 countries across all inhabited continents.

Methods: A multinational, 12-country cross-sectional study of 5779 children aged 9-11 years was conducted. Time spent in MVPA and sedentary behaviors was assessed by waist-worn accelerometry. Read More

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http://dx.doi.org/10.1038/s41366-019-0329-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445763PMC
April 2019
2 Reads
5.004 Impact Factor

Even a low dose of tamoxifen profoundly induces adipose tissue browning in female mice.

Int J Obes (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, and School of Molecular Biosciences, Washington State University, Pullman, WA, 99164, USA.

Background: Tamoxifen-inducible Cre/lox site-specific recombination technology has been widely used to generate conditional transgenic mice. As an estrogen receptor ligand, tamoxifen itself potentially affects energy metabolism, which may confound interpretation of data especially in metabolic studies. Considering sexual dimorphism, in this study, the effects of low-dose tamoxifen administration on energy metabolism, and browning of adipose tissues in female and male mice were investigated. Read More

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http://dx.doi.org/10.1038/s41366-019-0330-3DOI Listing
January 2019
5.004 Impact Factor

Defective fasting-induced PKA activation impairs adipose tissue glycogen degradation in obese Zucker rats.

Int J Obes (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Department of Physiology, University of Melbourne, Parkville, 3010, VIC, Australia.

Background: Obesity is associated with development of insulin resistance in adipose tissue (AT). Human obesity has been associated with increased glycogen deposition in adipocytes. Adipocytes synthesise glycogen prior to the formation of lipids. Read More

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http://dx.doi.org/10.1038/s41366-019-0327-yDOI Listing
January 2019
1 Read

Meal timing and obesity: interactions with macronutrient intake and chronotype.

Int J Obes (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.

Background: Timing of dietary intake may play a role in obesity. However, previous studies produced mixed findings possibly due to inconsistent approaches to characterize meal timing and not taking into account chronotype and macronutrients. To address the aforementioned limitations, we have defined meal timing relative to sleep/wake timing, investigated the relationship between meal timing and body mass index (BMI) dependent on chronotype, and examined the associations. Read More

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http://www.nature.com/articles/s41366-018-0284-x
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http://dx.doi.org/10.1038/s41366-018-0284-xDOI Listing
January 2019
10 Reads

Screening and brief intervention for obesity in primary care: cost-effectiveness analysis in the BWeL trial.

Int J Obes (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK.

Background: The Brief Intervention for Weight Loss Trial enrolled 1882 consecutively attending primary care patients who were obese and participants were randomised to physicians opportunistically endorsing, offering, and facilitating a referral to a weight loss programme (support) or recommending weight loss (advice). After one year, the support group lost 1.4 kg more (95%CI 0. Read More

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http://dx.doi.org/10.1038/s41366-018-0295-7DOI Listing
January 2019

Maternal metabolic factors during pregnancy predict early childhood growth trajectories and obesity risk: the CANDLE Study.

Int J Obes (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

Background: We investigated the individual and additive effects of three modifiable maternal metabolic factors, including pre-pregnancy overweight/obesity, gestational weight gain (GWG), and gestational diabetes mellitus (GDM), on early childhood growth trajectories and obesity risk.

Methods: A total of 1425 mother-offspring dyads (953 black and 472 white) from a longitudinal birth cohort were included in this study. Latent class growth modeling was performed to identify the trajectories of body mass index (BMI) from birth to 4 years in children. Read More

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http://dx.doi.org/10.1038/s41366-019-0326-zDOI Listing
January 2019
3 Reads

Association of obesity with morbidity and mortality in critically ill children: a systematic review and meta-analysis of observational studies.

Int J Obes (Lond) 2019 Apr 31;43(4):641-651. Epub 2019 Jan 31.

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Recent studies have suggested that obesity might be protective in specific conditions such as critical illness; however, there are controversial data in critically ill children with obesity. The aim of this study was to investigate the association of obesity with mortality and other outcomes in these patients. We conducted a systematic review of observational studies investigating obesity in critically ill children, published by August 2017 in PubMed and Scopus. Read More

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http://www.nature.com/articles/s41366-019-0319-y
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http://dx.doi.org/10.1038/s41366-019-0319-yDOI Listing
April 2019
10 Reads

Long-term diabetes outcomes after bariatric surgery-managing medication withdrawl.

Int J Obes (Lond) 2019 Jan 29. Epub 2019 Jan 29.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, Porto, Portugal.

Background/objectives: Bariatric surgery leads to type 2 diabetes mellitus (T2DM) remission, but recurrence can ensue afterwards. However, literature provides heterogenous remission/recurrence criteria and there is no consensus on long-term T2DM management after surgery. We aim to assess T2DM remission/recurrence rates using standardized criteria and to identify relapse predictors. Read More

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http://www.nature.com/articles/s41366-019-0320-5
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http://dx.doi.org/10.1038/s41366-019-0320-5DOI Listing
January 2019
11 Reads

Obesity is associated with altered gene expression in human tastebuds.

Int J Obes (Lond) 2019 Jan 29. Epub 2019 Jan 29.

CSIRO Health and Biosecurity, Sydney, Australia.

Background: The role of taste perception in the development and persistence of obesity is currently unclear due to conflicting results from psychophysical and other studies. No study to date has assessed whether there is an underlying fundamental difference in the physiology of taste tissue between lean and obese individuals.

Method/subjects: We analysed the transcriptomic profile (RNA-seq) of human fungiform taste papillae biopsied from lean (n = 23) and obese (n = 13) Caucasian females (age range 18-55) to identify differences in gene expression. Read More

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http://dx.doi.org/10.1038/s41366-018-0303-yDOI Listing
January 2019

Neighborhood racial/ethnic segregation and BMI: A longitudinal analysis of the Multi-ethnic Study of Atherosclerosis.

Int J Obes (Lond) 2019 Jan 22. Epub 2019 Jan 22.

Department of Epidemiology & Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.

Background: Current knowledge regarding the relationship between segregation and body weight is derived mainly from cross-sectional data. Longitudinal studies are needed to provide stronger causal inference.

Methods: We use longitudinal data from the Multi-Ethnic Study of Atherosclerosis and apply an econometric fixed-effect strategy, which accounts for all time-invariant confounders, and compare results to conventional cross-sectional analyses. Read More

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http://dx.doi.org/10.1038/s41366-019-0322-3DOI Listing
January 2019