5,066 results match your criteria International Journal of Neuroscience[Journal]


Small Interfering LncRNA-TUG1 (siTUG1) decreases ketamine-induced neurotoxicity in Rat Hippocampal Neurons.

Int J Neurosci 2019 Apr 17:1-17. Epub 2019 Apr 17.

b Department of Neurology , Yantai Yuhuangding Hospital.

Background: Ketamine (KET) is known to be used in pediatric anaesthetic, whereas many evidences revealed that KET generated neurotoxicity. In our study, we found KET decreased the level of LncRNA taurine-upregulated gene 1 (TUG1). Hence, the aim of our study is to investigate whether small interfering TUG1 (siTUG1) has effect on KET-induced rat hippocampal neurons. Read More

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http://dx.doi.org/10.1080/00207454.2019.1594805DOI Listing

The positive allosteric modulation of GABA receptors mRNA in immature hippocampal rat neurons by midazolam affects receptor expression and induces apoptosis.

Int J Neurosci 2019 Apr 7:1-12. Epub 2019 Apr 7.

a Department of Anesthesiology , University Hospital Regensburg , Regensburg , Germany .

Background: Numerous experimental studies show that anesthetics are potentially toxic to the immature brain. Even though benzodiazepines are widely used in pediatric anesthesia and intensive care medicine, only a few studies examine the effects of these drugs on immature neurons.

Methods: Hippocampal neuronal cell cultures of embryonic Wistar rats (15 days in culture) were incubated with midazolam 100 or 300 nM for either 30 min or 4h. Read More

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http://dx.doi.org/10.1080/00207454.2019.1604524DOI Listing

Therapeutic effects of aerobic exercise on EEG parameters and higher cognitive functions in mild cognitive impairment patients.

Int J Neurosci 2019 Jun;129(6):551-562

a Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences , National University of Sciences and Technology , Islamabad , Pakistan.

Background: Mild cognitive impairment (MCI) is becoming an emerging problem for developing countries where there is an increase in expected age. There is no specific curative therapeutic treatment available for these patients.

Objective: The objective of this study was to evaluate short and long-term changes in the electroencephalogram (EEG) parameters and cognition of MCI patients with aerobic exercises. Read More

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http://dx.doi.org/10.1080/00207454.2018.1551894DOI Listing
June 2019
1 Read

Association of miR-122, miR-124 miR-126 and miR-143 gene polymorphisms with ischemic stroke in the northern Chinese Han population.

Int J Neurosci 2019 Mar 21:1-12. Epub 2019 Mar 21.

a Department of Neurology , The First Affiliated Hospital of China Medical University , Shenyang 110001 , China.

Objectives Single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes can have diverse functional consequence by affecting the processing and target selection of miRNA. Recent evidence indicates that miRNA play important roles in the pathogenesis of atherosclerosis, which is a major cause of ischemic stroke (IS). The aim of this study was to clarify whether genetic variations in four miRNA genes (miR-143 rs4705342, miR-122 rs17669, miR-126 rs4636297, and miR-124 rs531564) contribute to IS susceptibility. Read More

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http://dx.doi.org/10.1080/00207454.2019.1593979DOI Listing

A novel in-frame mutation in CLN3 leads to Juvenile neuronal ceroid lipofuscinosis in a large Pakistani family.

Int J Neurosci 2019 Mar 20:1-6. Epub 2019 Mar 20.

a Human Molecular Genetics Laboratory , National Institute for Biotechnology and Genetic Engineering (NIBGE)-PIEAS , Faisalabad , Pakistan.

Aim: Neuronal ceroid lipofuscinosis (NCLs) are the most common neurodegenerative disorders, with global incidence of 1 in 100,000 live births. NCLs affect central nervous system, primarily cerebellar and cerebral cortices. Juvenile neuronal ceroid lipofuscinosis (JNCL), also known as Batten disease, is the most common form of NCLs. Read More

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http://dx.doi.org/10.1080/00207454.2019.1586686DOI Listing
March 2019
2 Reads

Bioinformatic analysis to explore key genes associated with brain ischemia-reperfusion injury in rats.

Int J Neurosci 2019 Mar 19:1-10. Epub 2019 Mar 19.

a Department of Neurology , The Fourth People's Hospital of Jinan , Jinan , Shandong , China.

Objectives: Ischemia-reperfusion (I/R) injury can aggravate the dysfunction and structural damage of tissues and organs. This study aimed at investigating the pathogenesis of I/R injury.

Methods: GSE82146 was extracted from Gene Expression Omnibus database, which included 12 nonischemic control (NIC) hippocampal tissues and 15 complete global brain ischemia (CGBI)-reperfusion hippocampal tissues. Read More

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http://dx.doi.org/10.1080/00207454.2019.1595615DOI Listing

Electroacupuncture-induced cannabinoid receptor expression in repair of abducens nerve.

Int J Neurosci 2019 Mar 19:1-7. Epub 2019 Mar 19.

b Department of Neurosurgery , Affiliated Hospital 2 of Nantong University , Nantong , Jiangsu , China.

Objective: Through the development of beagle abducens nerve injury model, taking electroacupuncture as the core and microglia as the starting point, the author investigated whether electroacupuncture can promote the repair of injured abducens nerve by cannabinoid receptor-mediated regulation of microglia activation.

Methods: Healthy beagle dogs were randomly divided into five groups: sham operation group (A), injury group (B), electroacupuncture pretreatment group (C), antagonist group (D) and solvent group (E). After stimulation with electroacupuncture, the expression of cannabinoid 1 receptor (CB1R) and cannabinoid 2 receptor (CB2R) in A, B and C microglia cells was detected by Western Bolt analysis, and further the expression of CB2R in five groups was further analyzed by immunofluorescence, thereby statistical differences were analyzed. Read More

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http://dx.doi.org/10.1080/00207454.2019.1593980DOI Listing
March 2019
1.528 Impact Factor

The expression of voltage-gated sodium channels in trigeminal nerve following chronic constriction injury in rats.

Int J Neurosci 2019 Mar 19:1-8. Epub 2019 Mar 19.

a Department of Neurosurgery , XinHua Hospital (The Cranial Nerve Disease Center of Shanghai), Shanghai JiaoTong University School of Medicine , Shanghai , China.

Objectives: Despite the etiology of trigeminal neuralgia has been verified by microvascular decompression as vascular compression of the trigeminal root, very few researches concerning its underlying pathogenesis has been reported in the literature. The present study focused on those voltage-gated sodium channels, which are the structural basis for generation of ectopic action potentials.

Methods: The trigeminal neuralgia modeling was obtained with infraorbital nerve chronic constriction injury (ION-CCI) in rats. Read More

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http://dx.doi.org/10.1080/00207454.2019.1595616DOI Listing
March 2019
3 Reads

Boron's neurophysiological effects and tumoricidal activity on glioblastoma cells with implications for clinical treatment.

Int J Neurosci 2019 Mar 18:1-15. Epub 2019 Mar 18.

d Department of Neurosurgery , Acibadem Hospital , Istanbul , Turkey.

Purpose: To define the actions of boron on normal neurophysiology and glioblastoma growth.

Materials And Methods: PubMed and other relevant databases were searched.

Results: Discovery of novel boron compounds in treatment of glioblastoma is being actively investigated, but the majority of such studies is focused on the synthesis of boron compounds as sensitizers to Boron Neutron Capture Therapy (BNCT). Read More

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http://dx.doi.org/10.1080/00207454.2019.1595618DOI Listing

Effects of major adipokines and the -420 C > G resistin gene polymorphism on the long-term outcome of patients with acute ischemic stroke.

Int J Neurosci 2019 Mar 18:1-8. Epub 2019 Mar 18.

a First Propedeutic Department of Internal Medicine , AHEPA Hospital, School of Health Sciences, Aristotle University of Thessaloniki , Thessaloniki , Greece.

Aim: The association between adiponectin, leptin, and resistin and the long-term outcome of ischemic stroke are controversial. We aimed to evaluate this relationship.

Methods: We prospectively studied 83 patients consecutively hospitalized for acute ischemic stroke (38. Read More

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http://dx.doi.org/10.1080/00207454.2019.1596906DOI Listing

Clustering analysis to identify key genes associated with motor neuron excitability following spinal cord injury.

Int J Neurosci 2019 Mar 1:1-8. Epub 2019 Mar 1.

a Spine Surgery , Jining No. 1 People's Hospital , Jining , Shandong Province , China.

Purpose: As a neurodegenerative disease, spinal cord injury can lead to the loss of autonomic function, muscle function, or sensation. This study is designed to identify the key genes implicated in the excitability of motor neurons following spinal cord injury.

Materials And Methods: The GSE19701 dataset was obtained from Gene Expression Omnibus. Read More

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http://dx.doi.org/10.1080/00207454.2019.1576661DOI Listing

Thalidomide alleviates bone cancer pain by down-regulating expressions of NF-κB and GFAP in spinal astrocytes in a mouse model.

Int J Neurosci 2019 Feb 26:1-8. Epub 2019 Feb 26.

b Department of Anesthesiology , The First Hospital of Shijiazhuang , Shijiazhuang , China.

Aim: Thalidomide is one of the first line therapies in cancer pain management. Previous study has shown that thalidomide decreases the expression of tumor necrosis factor alpha in the mouse spinal cord. However, the exact cellular and molecular mechanism underlying the effect of thalidomide remains unclear. Read More

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http://dx.doi.org/10.1080/00207454.2019.1586687DOI Listing
February 2019
4 Reads

Functional brain segregation changes during demanding mathematical task.

Int J Neurosci 2019 Feb 22:1-12. Epub 2019 Feb 22.

d Department of Physics, Faculty of Science , University of Zanjan , Zanjan , Iran.

The neural basis of demanding mathematical problem solving is currently indeterminate and unclear. Mathematical problem solving engages higher order cognition and a complex associative activity of functional neural networks occurs during demanding problem solving. Twenty right handed subjects (mean age: 24. Read More

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http://dx.doi.org/10.1080/00207454.2019.1586688DOI Listing
February 2019

Bilateral subthalmic nucleus deep brain stimulation with microelectrode recordings in the setting of mild inherited hemophilia B: a case report.

Int J Neurosci 2019 Feb 22:1-3. Epub 2019 Feb 22.

c Department of Neurosurgery , University of Kansas Medical Center , Kansas City , KS , USA.

Hemophilia B is an X linked recessive deficiency of factor IX that presents with a range of clinical severity that co-relates with factor levels. Although guidelines exist to guide perioperative hemostasis in such patients, there is scarce data on elective high-risk neurosurgeries, resulting in a reluctance to offer these patients elective neurosurgeries. These patients thus rarely if ever undergo such procedures. Read More

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http://dx.doi.org/10.1080/00207454.2019.1586685DOI Listing
February 2019
1 Read

Gene and protein expression profiles of JAK-STAT signalling pathway in the developing brain of the Ts1Cje down syndrome mouse model.

Int J Neurosci 2019 Feb 18:1-11. Epub 2019 Feb 18.

a Genetics and Regenerative Medicine Research Centre (GRMRC), Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , Selangor , Malaysia.

Aims: The JAK-STAT signalling pathway is one of the key regulators of pro-gliogenesis process during brain development. Down syndrome (DS) individuals, as well as DS mouse models, exhibit an increased number of astrocytes, suggesting an imbalance of neurogenic-to-gliogenic shift attributed to dysregulated JAK-STAT signalling pathway. The gene and protein expression profiles of JAK-STAT pathway members have not been characterised in the DS models. Read More

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http://dx.doi.org/10.1080/00207454.2019.1580280DOI Listing
February 2019

Characterization of functional brain connectivity towards optimization of music selection for therapy: a fMRI study.

Int J Neurosci 2019 Feb 11:1-8. Epub 2019 Feb 11.

a Houston Methodist Hospital , Center for Performing Arts Medicine , Houston , Texas , USA.

Background: Music therapy, a nontraditional approach to patient care, has long been used to achieve a wide variety of positive results. To deepen our understanding of the connection and therapeutic potential of music, the effect of music therapy and music medicine (music administered to individuals without an interactive therapeutic relationship) on the brain remains a topic of active research.

Objective: This study is aimed at investigating the effect of different music genres and individualized music selection on brain functional connectivity (FC) measured by functional magnetic resonance imaging (fMRI). Read More

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http://dx.doi.org/10.1080/00207454.2019.1581189DOI Listing
February 2019
1 Read

High signal-intensity abnormalities in susceptibility-weighted imaging for primary intracerebral hemorrhage.

Int J Neurosci 2019 Feb 6:1-6. Epub 2019 Feb 6.

a Department of Neurology , Renmin Hospital of Wuhan University , Wuhan , Hubei Province , P. R. China.

Purpose: To identify the regularity of signal evolution of intracerebral hemorrhage on susceptibility-weighted imaging (SWI) at different stages compared with T1-weighted imaging (T1WI) and T2-weighted imaging (T2WI).

Methods: We retrospectively evaluated a series of 365 patients who underwent T1WI, T2WI, and SWI examination simultaneously or sequentially in our hospital from January 2015 to May 2017. Two neuroradiologists assessed the images and discrepancies between their interpretations were resolved by consensus. Read More

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http://dx.doi.org/10.1080/00207454.2019.1576659DOI Listing
February 2019

Aquaporin-4 antibody positive neuromyelitis optica spectrum disorder subsequent to rhabdomyolysis: a case report and literature review.

Int J Neurosci 2019 Feb 5:1-3. Epub 2019 Feb 5.

a Department of Neurology, Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , China.

Rhabdomyolysis could be caused by various mechanisms including autoimmune reaction. Here, we reported a case of 76-year-old-woman diagnosed with aquaporin-4 (AQP4) IgG positive neuromyelitis optica spectrum disorder (NMOSD) following rhabdomyolysis. After a review of literature, we propose that physical injury of skeletal muscle cells may lead to the production of AQP4 IgG and this AQP4 IgG might further decrease in the stability of skeletal muscle cells creating a positive feedback loop. Read More

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http://dx.doi.org/10.1080/00207454.2019.1579718DOI Listing
February 2019

Eyes are mirror of the brain: comparison of multiple sclerosis patients and healthy controls using OCT.

Int J Neurosci 2019 Jan 29:1-8. Epub 2019 Jan 29.

a Department of Ophthalmology , College of Medicine , Abant Izzet Baysal University , Bolu , Turkey.

Objective: To evaluate the thickness of choroid and retinal nerve fiber layer (RNFL) in multiple sclerosis (MS) patients with and without optic neuritis using enhanced depth imaging optical coherence tomography (EDI-OCT).

Methods: In this cross-sectional study, both eyes of 52 MS patients [n = 104 eyes; 62 eyes of MS patients without optic neuritis (MS-NON) and 42 eyes of MS patients with optic neuritis (MS-ON)] and only one eye of 36 healthy control subjects (n = 36 eyes) were evaluated. Complete ophthalmologic examination and EDI-OCT scanning were completed for all participants. Read More

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http://dx.doi.org/10.1080/00207454.2019.1576660DOI Listing
January 2019

hif-1 plays a role in hypoxia-induced gustatory plasticity of Caenorhabditis elegans.

Int J Neurosci 2019 Jan 29:1-7. Epub 2019 Jan 29.

b Department of Biology & Biochemistry , University of Bath , Bath , United Kingdom.

Background: Hypoxia-inducible factor 1 (HIF-1) is a key transcription factor in the detection of low oxygen levels, inducing expression of genes involved in mediating the response to hypoxia to maintain cellular oxygen homeostasis. Caenorhabditis elegans is a soil nematode that has evolved specialized chemosensory neurons that detect changes in oxygen levels and guide its behaviour and responses to food. The role of the hif-1 gene in modifying chemosensory behaviour in response to chemical hypoxia however remains unclear. Read More

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http://dx.doi.org/10.1080/00207454.2019.1576662DOI Listing
January 2019

Osthole alleviates MPTP-induced Parkinson's disease mice by suppressing Notch signaling pathway.

Int J Neurosci 2019 Jan 22:1-9. Epub 2019 Jan 22.

a Department of Neurology, Xuzhou Key Laboratory of Neurobiology , Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University , Xuzhou , China.

Objectives: Parkinson's disease (PD) is an age-related neurodegenerative disease characterized by motor dysfunctions. Dopaminergic neuron loss, inflammation and oxidative stress responses play key roles in the pathogenisis of PD. Osthole (Ost), a natural coumarin derivative, isolated from various herbs such as Cnidium monnieri (L. Read More

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http://dx.doi.org/10.1080/00207454.2019.1573171DOI Listing
January 2019
17 Reads
1.528 Impact Factor

Activation of the Nrf2-ARE signal pathway after blast induced traumatic brain injury in mice.

Int J Neurosci 2019 Jan 16:1-7. Epub 2019 Jan 16.

a Department of Neurosurgery , Jinling Hospital, Jinling School of Clinical Medicine, Nanjing Medical University , Jiangsu , Nanjing , China.

Background: Treatment of blast-induced traumatic brain injury (bTBI) has been hindered. Previous studies have demonstrated that oxidative stress may contribute to the pathophysiological process. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) signaling pathway exhibits a protective effect after traumatic brain injury (TBI). Read More

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http://dx.doi.org/10.1080/00207454.2019.1569652DOI Listing
January 2019
3 Reads

First emerging objective experimental evidence of hearing impairment following subarachnoid haemorrhage; Felix culpa, phonophobia, and elucidation of the role of trigeminal ganglion.

Int J Neurosci 2019 Jan 14:1-7. Epub 2019 Jan 14.

h Department of Neurosurgery , Okmeydanı Training and Research Hospital , Istanbul , Turkey.

Objective: The exact mechanism of phonophobia induced by subarachnoid hemorrhage (SAH) has not been understood well. This subject was investigated.

Material And Methods: This study was conducted on 25 rabbits. Read More

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https://www.tandfonline.com/doi/full/10.1080/00207454.2019.1
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http://dx.doi.org/10.1080/00207454.2019.1569651DOI Listing
January 2019
11 Reads

Exposure to antenatal corticosteroids and reduced respiratory sinus arrhythmia in adult survivors of extremely low birth weight.

Int J Neurosci 2019 Jan 11:1-8. Epub 2019 Jan 11.

a Department of Psychiatry and Behavioural Neurosciences , McMaster University , Hamilton , Canada.

Purpose/aim: Antenatal corticosteroid (ACS) therapy has dramatically increased survival rates among extremely low birth weight (ELBW) infants. However, the long-term effects of ACS on autonomic nervous system function have not been explored. Using the world's oldest longitudinally followed cohort of ELBW infants we compared respiratory sinus arrhythmia (RSA) among ELBW survivors whose mothers received ACS (ELBW-S), those who did not (ELBW-NS) and normal birth weight (NBW) controls in their 20 and 30 s. Read More

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http://dx.doi.org/10.1080/00207454.2019.1567511DOI Listing
January 2019
1 Read

Clinical features of patients with anti-leucine-rich glioma inactivated-1 protein associated encephalitis: a Chinese case series.

Int J Neurosci 2019 Jan 9:1-8. Epub 2019 Jan 9.

a Department of Neurology , Qilu Hospital, Shandong University , Shandong Sheng , China.

Purpose: Antibodies against leucine-rich glioma inactivated 1 (LGI1) are associated with limbic encephalitis and faciobrachial dystonic seizures (FBDS). We present a large series of Han Chinese patients for further clinical refinement.

Materials And Methods: Serum and cerebrospinal fluid samples from patients were tested. Read More

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http://dx.doi.org/10.1080/00207454.2019.1567507DOI Listing
January 2019
3 Reads

Role of hesperidin in P2X3 receptor-mediated neuropathic pain in the dorsal root ganglia.

Int J Neurosci 2019 Jan 9:1-10. Epub 2019 Jan 9.

c Department of Physiology , Medical School of Nanchang University , Nanchang , PR China.

Aim: This study investigated whether the neuronal P2X3 receptor in rat dorsal root ganglia (DRG) mediated the effects of hesperidin on neuropathic pain.

Materials And Methods: The chronic constriction injury (CCI) model was used as a model of neuropathic pain. The mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured. Read More

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http://dx.doi.org/10.1080/00207454.2019.1567512DOI Listing
January 2019
2 Reads

A technical concept of a computer game for patients with Parkinson's disease - a new form of PC-based physiotherapy.

Int J Neurosci 2019 Jan 9:1-6. Epub 2019 Jan 9.

b University Leipzig, Faculty of Medicine , Department of Neurosurgery , Leipzig , Germany.

Background: At present, there are no meaningful and sophisticated computer games that simultaneously allow the treatment of movement disorders such as Parkinson's syndrome. In particular, there are no systems to consider the severity of the disease and the physical skills of the patient.

Methods: A computer game using the Microsoft Kinect as markerless sensor for the 3 D recognition of the patient's movement was developed to support the rehabilitation. Read More

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http://dx.doi.org/10.1080/00207454.2019.1567510DOI Listing
January 2019
2 Reads

Primary culture of mouse embryonic spinal cord neurons: cell composition and suitability for axonal regeneration studies.

Int J Neurosci 2019 Jan 9:1-8. Epub 2019 Jan 9.

a National Research Center Kurchatov Institute , Moscow , Russian Federation.

Objective: Primary culture is an effective experimental model to study molecular mechanisms that drive axonal regeneration after central nervous system injury. However, the culture of spinal cord (SC) cells remains poorly characterized. Here, we have analyzed the cell composition of a primary SC culture during its maturation. Read More

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http://dx.doi.org/10.1080/00207454.2019.1567508DOI Listing
January 2019
1 Read

Motor imagery in stroke patients: a descriptive review on a multidimensional ability.

Int J Neurosci 2019 Jan 9:1-12. Epub 2019 Jan 9.

a IRCCS Centro Neurolesi "Bonino-Pulejo" , Department of Neurobioimaging, Messina , Italy.

Purpose/aim: Motor imagery (MI) is the mental representation of a movement without engaging its actual execution. MI shares neuroanatomical correlates with brain motor networks. Neurologic disorders affecting motor skills, such as stroke, have been related to impairments in MI. Read More

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http://dx.doi.org/10.1080/00207454.2019.1567509DOI Listing
January 2019
15 Reads

Parkinson's pain is more aching and interfering with social life in Caucasians compared to Indians.

Int J Neurosci 2019 Jan 7:1-8. Epub 2019 Jan 7.

e Faculty of Medicine and Dentistry , James Cook University , Townsville , Australia.

Objectives: Although there have been numerous studies conducted to better understand Parkinson's disease (PD), the epidemiology of its debilitating non-motor symptoms across different ethnicities remains understudied. Herein we explore the relationship between depression, anxiety and pain in PD patients of Caucasian or Indian ethnicity (PD Caucasians and PD Indians).

Patients And Methods: All patients and healthy age and gender matched controls were assessed via semi-structured interviews for anxiety, pain and depression using structured questionnaires. Read More

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http://dx.doi.org/10.1080/00207454.2019.1566232DOI Listing
January 2019
1 Read

Prospective memory impairment in patients with white matter lesions.

Int J Neurosci 2019 May 7;129(5):438-446. Epub 2019 Jan 7.

a Department of Neurology , The First Affiliated Hospital of Anhui Medical University , Hefei , Anhui Province , China.

Objective: A vast majority of the episodic memory literature in white matter lesions (WML) had focused on "retrospective memory (RM)", little was known about prospective memory (PM) in WML patients. The aim of our study was to investigate the effect of WML patients on event-based prospective memory (EBPM) and time-based prospective memory (TBPM). In addition, our study attempted to understand the possible mechanisms of PM damage in WML patients. Read More

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http://dx.doi.org/10.1080/00207454.2018.1538988DOI Listing
May 2019
3 Reads

FoxO3 transcription factor promotes autophagy after transient cerebral ischemia/reperfusion.

Int J Neurosci 2018 Dec 31:1-8. Epub 2018 Dec 31.

b Basic Medical Research Centre, Medical School , Nantong University , Nantong , People's Republic of China.

Aim: Autophagy was activated after cerebral ischemia reperfusion (I/R) injury. However, the molecular mechanisms underlying regulation of autophagy in cerebral I/R injury were not completely understood. Studies reported that Forked-box class O (FoxO) transcription factors involved in autophagy and might be the regulator of autophagy in multiple cells. Read More

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http://dx.doi.org/10.1080/00207454.2018.1564290DOI Listing
December 2018
1 Read

Postoperative cognitive dysfunction and the possible underlying neurodegenerative effect of anaesthesia.

Int J Neurosci 2018 Dec 27:1-9. Epub 2018 Dec 27.

d Department of Clinical and Chemical Pathology , Beni-Suef University , Beni-Suef , Egypt.

Introduction: There is alarming evidence about the involvement of general anaesthesia in the development of postoperative cognitive dysfunction.

Aim: To clarify the impact of general anaesthesia on cognitive function and to study the possible effect of general anaesthesia on serum S100B, the marker of neuronal degeneration.

Methods: This is a prospective randomised controlled study carried out on 50 patients undergoing elective laparoscopic cholecystectomy under conventional general anaesthesia. Read More

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https://www.tandfonline.com/doi/full/10.1080/00207454.2018.1
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http://dx.doi.org/10.1080/00207454.2018.1561451DOI Listing
December 2018
3 Reads

Isolated brainstem involvement in posterior reversible encephalopathy syndrome: a case report and review of the literature.

Int J Neurosci 2018 Dec 27:1-6. Epub 2018 Dec 27.

a Department of Neurology, Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , China.

Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiological syndrome, reversible vasogenic edema predominantly within parieto-occipital regions. However, isolated brainstem involvement in PRES has been rarely reported, little is known about its clinical manifestations, radiological features and outcomes. We reported a case with PRES with only brainstem involvement and performed a systematic review of published cases. Read More

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http://dx.doi.org/10.1080/00207454.2018.1561452DOI Listing
December 2018
1 Read

Effect of teriparatide use on bone mineral density and spinal fusion: a narrative review of animal models.

Int J Neurosci 2018 Dec 27:1-7. Epub 2018 Dec 27.

c Department of Orthopaedic Surgery , Mayo Clinic , Rochester , MN , USA.

Purpose Of The Study: Teriparatide (Human recombinant Parathyroid Hormone 1-34) is an anabolic agent that is frequently used in patients with osteoporosis and has been extensively investigated with animal model and clinical studies in current literature. The purpose of the study was to evaluate the impact of teriparatide on bone mineral density and fusion.

Materials And Methods: The findings from preclinical studies that have investigated the role of teriparatide in animal models are summarized in presented review. Read More

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http://dx.doi.org/10.1080/00207454.2018.1564051DOI Listing
December 2018
2 Reads

The Effect of Serotonin on Penicillin-induced Epileptiform Activity.

Int J Neurosci 2018 Dec 7:1-14. Epub 2018 Dec 7.

c Department of Physiology, Faculty of Medicine , Ondokuz Mayıs University , Samsun , Turkey , e-mail:

This study was aimed at examining the epileptiform activity of the 5-HT serotonin receptor agonist and antagonist, and 5-hydroxytryptophan (5-HTP) in penicillin-induced epilepsy in albino Wistar rats. For this purpose, 90 albino male Wistar rats were used in this study. Epileptiform activity was induced by an injection of penicillin, an agonist of GABAA receptor, (500 IU, ic) into the somatomotor cortex. Read More

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http://dx.doi.org/10.1080/00207454.2018.1557166DOI Listing
December 2018
3 Reads

Estimation of skeletal muscle mass in patients with spinocerebellar ataxia type 3 and 10.

Int J Neurosci 2018 Dec 7:1-5. Epub 2018 Dec 7.

f Department of Medicine , Faculdades Pequeno Príncipe , Curitiba , PR , Brazil.

Background: Neurodegenerative diseases may progress to a level in which patients present spontaneous weight loss, resulting in increased falls and functional disabilities when the disease is associated with muscle mass depletion.

Objective: Evaluate the muscle compartment in patients presenting spinocerebellar ataxia (SCA) type 3 and 10.

Methods: Forty-six patients presenting SCA type 3 and 10 were assessed and 76 volunteers were selected to the control group. Read More

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http://dx.doi.org/10.1080/00207454.2018.1557167DOI Listing
December 2018
2 Reads

Protective mechanism of Wnt4 gene on Parkinson's disease (PD) transgenic Drosophila.

Int J Neurosci 2018 Dec 11:1-12. Epub 2018 Dec 11.

d Basic Medical College, Guilin Medical University , Guilin , China.

Objective: The main pathological change of Parkinson's disease (PD) is progressive degeneration and necrosis of dopaminergic neurons in the midbrain, forming a Lewy body in many of the remaining neurons. Studies have found that in transgenic Drosophila, mutations in the PTEN-inducible kinase 1 (PINK1) gene may cause indirect flight muscle defects in Drosophila, and mitochondrial structural dysfunction as well.

Methods: In this study, Wnt4 gene overexpression and knockdown were performed in PINK1 mutant PD transgenic Drosophila, and the protective effect of Wnt4 gene on PD transgenic Drosophila and its possible mechanism were explored. Read More

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http://dx.doi.org/10.1080/00207454.2018.1557168DOI Listing
December 2018
3 Reads

Anaplastic oligodendroglioma metastasizing to the bone marrow: a unique case report and literature review.

Int J Neurosci 2018 Dec 11:1-7. Epub 2018 Dec 11.

c Baptist Health , Louisville , KY , USA.

Oligodendrogliomas are a rare type of primary brain tumor. They are genetically defined as diffuse gliomas carrying mutation in isocitrate dehydrogenase type 1 (IDH1) or type 2 (IDH2) and codeletion of chromosomes 1p and 19q. The WHO grading system distinguishes two histopathologic grades of ODs: grade II (low-grade) and grade III (anaplastic oligodendroglioma or AO). Read More

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http://dx.doi.org/10.1080/00207454.2018.1557165DOI Listing
December 2018
5 Reads

Perampanel in patients with brain tumor-related epilepsy in real-life clinical practice: a retrospective analysis.

Int J Neurosci 2019 Jun 26;129(6):593-597. Epub 2018 Dec 26.

e Biostatistic Unit , Regina Elena National Cancer Institute , Rome , Italy.

Introduction: Epilepsy occurs in 35-70% of patients with gliomas; glutamate plays a central role via AMPA-receptor activation, which is involved both in seizure activity and tumor growth. We conducted a retrospective study on brain tumor-related epilepsy patients (BTRE) treated with perampanel in add-on (PER) for 12 months, to evaluate efficacy and tollerability, according to real-life clinical practice.

Materials And Methods: Medical records of eleven patients (9 males, mean age 54 years) with glioma and epilepsy treated with PER in add-on, for inadequate seizure control or adverse events (AEs) from previous antiepileptic drugs (AEDs) therapy, were reviewed. Read More

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http://dx.doi.org/10.1080/00207454.2018.1555160DOI Listing
June 2019
7 Reads

Shyness, hormones, and quality of life among adults with schizophrenia.

Int J Neurosci 2019 May 5;129(5):470-480. Epub 2018 Dec 5.

a Department of Psychology, Neuroscience & Behaviour , McMaster University , Hamilton , Ontario , Canada.

Objective: Although individual differences in personality are known to influence quality of life in individuals with schizophrenia, relatively few studies have attempted to identify putative links underlying this relation.

Methods: Here, we examined associations among temperamental shyness, hormones (ie baseline salivary cortisol and testosterone), and quality of life (QoL) measured in 42 stable outpatient adults with schizophrenia.

Results: We found that baseline cortisol, but not testosterone, moderated the relation between shyness and QoL (ß = 1. Read More

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http://dx.doi.org/10.1080/00207454.2018.1543293DOI Listing
May 2019
7 Reads

Measuring abnormal intrinsic brain activities in patients with retinal detachment using amplitude of low-frequency fluctuation: a resting-state fMRI study.

Int J Neurosci 2018 Nov 30:1-6. Epub 2018 Nov 30.

a Department of Ophthalmology , The First Affiliated Hospital of Nanchang University , Nanchang , Jiangxi , China.

Objective: The targets of this study were to access the alternations of spontaneous brain activity in RD patients by amplitude of low-frequency fluctuation (ALFF) method and to explore their relationships with clinical behavioral performance.

Methods: A total of 20 patients with RD (6 males and 14 females), and 20 healthy controls (HCs) (6 males and 14 females) were recruited, and were matched in sex and age. All participants finished the functional magnetic resonance imaging (fMRI) scanning. Read More

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http://dx.doi.org/10.1080/00207454.2018.1554657DOI Listing
November 2018
2 Reads

Cognitive functions and psychological symptoms in migraine: a study on patients with and without aura.

Int J Neurosci 2019 Jun 23;129(6):588-592. Epub 2018 Dec 23.

a IRCCS Centro Neurolesi "Bonino-Pulejo" , Messina , Italy.

Aim: Migraine is neurological disorder with a complex pathophysiology. We described the neuropsychological profile of 100 migraineurs (50 with visual aura and 50 without aura), in interictal phase, compared to 50 matched healthy controls.

Materials And Methods: A battery of standardized neuropsychological tests was used to assess attention, memory and executive functions. Read More

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http://dx.doi.org/10.1080/00207454.2018.1554658DOI Listing
June 2019
2 Reads

Maternal separation induces long-term changes in mineralocorticoid receptor in rats subjected to chronic stress and treated with tianeptine.

Int J Neurosci 2019 Jun 26;129(6):540-550. Epub 2018 Dec 26.

a Facultad de Ciencias Exactas, Físicas y Naturales , Universidad Nacional de Córdoba, Laboratorio de Fisiología Animal , Córdoba , Argentina.

Purpose: The aim of this study was to analyze whether early maternal separation would result in long-term, persistent alterations in stress response in adulthood, altering mineralocorticoid receptor immunoreactivity (MR-ir) in the dorsal hippocampal areas [CA1, CA2, CA3 and dentate gyrus (DG)], paraventricular nucleus of the hypothalamus and medial and central nucleus of the amygdala, key structures involved in stress response regulation. We also analyzed whether chronic treatment with the antidepressant tianeptine reverses these possible changes.

Material And Methods: Male Wistar rats were subjected to daily maternal separation for 4. Read More

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http://dx.doi.org/10.1080/00207454.2018.1550398DOI Listing
June 2019
2 Reads

Effects of stimulus-related variables on mental states recognition in Huntington's disease.

Int J Neurosci 2019 Jun 20;129(6):563-572. Epub 2018 Dec 20.

b Huntington and Rare Diseases Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , Italy.

Background: Cognitive abnormalities in Huntington's Disease (HD) can involve the specific impairment of the social perspective taking as well as difficulties in recognizing others' mental state many years before the onset of motor symptoms.

Aims: At the scope of assessing how the difficulties in mental state recognition might be an HD early sign before motor symptoms appear, our study was aimed to investigate how the recognition of others' mental states in HD subjects is moderated by different stimulus related features (gender, difficulty (low, medium, high), and valence (positive, negative, neutral) of the mental states that are to be recognized).

Methods: Subjects with premanifest (n = 20) and manifest (n = 40) HD performed the revised 'Reading the Mind in the Eyes Test' and were compared with age-matched healthy controls (HC, 40 subjects per cohort). Read More

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http://dx.doi.org/10.1080/00207454.2018.1552691DOI Listing
June 2019
20 Reads

Adult convulsive status epileptic us: clinical, etiological, and predictors of outcome study from rural population of North India.

Int J Neurosci 2019 Jun 20;129(6):573-579. Epub 2018 Dec 20.

d Forensic Medicine and Toxicology , UP University of Medical Sciences , Saifai , Etawah , Uttar Pradesh , India.

Aim: To determine the clinical profile, etiologies and predictors of mortality in patients with convulsive status epilepticus (CSE) among rural population of North India in view of limited published data on epidemiology and etiology of status epilepticus (SE) from developing countries.

Methods: One hundred sixty-two consecutive adult patients with CSE were evaluated from 2016 to 2018 for demographic profile, etiologies and predictors of poor outcome.

Results: The mean age was 41. Read More

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https://www.tandfonline.com/doi/full/10.1080/00207454.2018.1
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http://dx.doi.org/10.1080/00207454.2018.1552692DOI Listing
June 2019
17 Reads

Morphological consequences of acoustic trauma on cochlear hair cells and the auditory nerve.

Int J Neurosci 2019 Jun 20;129(6):580-587. Epub 2018 Dec 20.

a CILcare. 2214, Boulevard de la Lironde , Parc Scientifique Agropolis , Montpellier , France.

Aims: Hearing loss is the most common form of sensory impairment in humans. Short impulses of a high intensity noise can trigger sudden hearing loss, which is generally irreversible and associated with structural tissue damage of the cochlea and auditory nerve. It is well established that myelination is essential for the rapid propagation of action potentials along axons, and that Schwann cells are responsible for myelin sheath production in the peripheral nervous system. Read More

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http://dx.doi.org/10.1080/00207454.2018.1552693DOI Listing
June 2019
2 Reads

An elderly patient with Alzheimer's disease, normal pressure hydrocephalus and traumatic brain injury: presented with behavioral symptoms similar to behavioral variant frontotemporal dementia.

Int J Neurosci 2019 Jun 21;129(6):623-626. Epub 2018 Dec 21.

a Department of Geriatric Medicine , Dokuz Eylul University, Faculty of Medicine , Izmir , Turkey.

Objective: Traumatic brain injury (TBI) is nondegenerative insult to brain from external mechanical forces. It may cause cognitive impairment, psychological problems in the long period. Besides traumatic brain injury also induces neuroinflammation and neurodegeneration process, and increases risk of dementia. Read More

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http://dx.doi.org/10.1080/00207454.2018.1552690DOI Listing
June 2019
43 Reads

Edaravone inhibits autophagy after neuronal oxygen-glucose deprivation/recovery injury.

Int J Neurosci 2019 May 9;129(5):501-510. Epub 2019 Jan 9.

b Department of Orthopaedics , The First Affiliated Hospital with Nanjing Medical University , Nanjing , China.

Purpose Of The Study: Edaravone is an oxygen free radical scavenger that is widely used to treat ischemic injury to the nervous system. This study investigated the effect of edaravone pretreatment on neurons subjected to oxygen-glucose deprivation/recovery (OGD/R) injury.

Materials And Methods: Common neurons were subjected to oxygen and glucose deprivation for 1 h, followed by oxygen and glucose recovery for 0. Read More

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http://dx.doi.org/10.1080/00207454.2018.1550399DOI Listing
May 2019
6 Reads
1.528 Impact Factor

Not all clots are created equal: a review of deficient thrombolysis with tissue plasminogen activator (tPA) in patients with metabolic syndrome.

Int J Neurosci 2019 Jun 27;129(6):612-618. Epub 2018 Dec 27.

c Department of Physiology Pharmacology & Neuroscience , West Virginia University , Morgantown , WV , USA.

Metabolic syndrome is a cluster of cardiovascular risk factors associated with a prothrombotic, proinflammatory and hypofibrinolysis state. Although resistance to tissue plasminogen activator (tPA) in metabolic syndrome patients has been associated with a defective fibrinolytic system, the factors and mechanisms underlining such resistance is unclear. While there is a great debate on proposed mechanisms, fundamental questions regarding resistance to tPA in metabolic syndrome patients with ischemic stroke remain unanswered. Read More

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http://dx.doi.org/10.1080/00207454.2018.1550400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443479PMC
June 2019
14 Reads