5,053 results match your criteria International Journal of Neuroscience[Journal]


Gene and protein expression profiles of JAK-STAT signalling pathway in the developing brain of the Ts1Cje down syndrome mouse model.

Int J Neurosci 2019 Feb 18:1-11. Epub 2019 Feb 18.

a Genetics and Regenerative Medicine Research Centre (GRMRC), Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , Selangor , Malaysia.

Aims: The JAK-STAT signalling pathway is one of the key regulators of pro-gliogenesis process during brain development. Down syndrome (DS) individuals, as well as DS mouse models, exhibit an increased number of astrocytes, suggesting an imbalance of neurogenic-to-gliogenic shift attributed to dysregulated JAK-STAT signalling pathway. The gene and protein expression profiles of JAK-STAT pathway members have not been characterised in the DS models. Read More

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http://dx.doi.org/10.1080/00207454.2019.1580280DOI Listing
February 2019

Characterization of Functional Brain Connectivity towards Optimization of Music Selection for Therapy - A fMRI study.

Int J Neurosci 2019 Feb 11:1-9. Epub 2019 Feb 11.

b MRI core, Houston Methodist Research Institute , Houston TX , USA.

Background: Music therapy, a non-traditional approach to patient care, has long been used to achieve a wide variety of positive results. A better understanding of the connection and therapeutic potential of music, music therapy, and music medicine (music administered without an interactive therapeutic relationship) to individuals by exploring music's effect on the brain remains a topic of active research.

Objective: This study is aimed at investigating the effect of different music genres and individualized music selection on brain functional connectivity (FC) measured by functional magnetic resonance imaging (fMRI). Read More

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http://dx.doi.org/10.1080/00207454.2019.1581189DOI Listing
February 2019

High Signal-Intensity Abnormalities in Susceptibility-weighted Imaging for Primary Intracerebral Hemorrhage.

Int J Neurosci 2019 Feb 6:1-9. Epub 2019 Feb 6.

a Department of Neurology , Renmin Hospital of Wuhan University , Wuhan 430060 , Hubei Province , P. R. China.

Purpose: To identify the regularity of signal evolution of intracerebral hemorrhage on susceptibility-weighted imaging (SWI) at different stages compared with T1-weighted imaging (T1WI) and T2-weighted imaging (T2WI).

Methods: We retrospectively evaluated a series of 365 patients who underwent T1WI, T2WI, and SWI examination simultaneously or sequentially in our hospital from January 2015 to May 2017. Two neuroradiologists assessed the images and discrepancies between their interpretations were resolved by consensus. Read More

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http://dx.doi.org/10.1080/00207454.2019.1576659DOI Listing
February 2019

Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder Subsequent to Rhabdomyolysis: A Case Report and Literature Review.

Int J Neurosci 2019 Feb 5:1-4. Epub 2019 Feb 5.

a Department of Neurology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030 , China.

Rhabdomyolysis could be caused by various mechanisms including autoimmune reaction. Here we reported a case of 76-year-woman diagnosed with aquaporin-4 (AQP4) IgG positive neuromyelitis optica spectrum disorder (NMOSD) following rhabdomyolysis. After a review of literature, we propose that physical injury of skeletal muscle cells may lead to the production of AQP4 IgG and this AQP4 IgG might further decrease the stability of skeletal muscle cells creating a positive feedback loop. Read More

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http://dx.doi.org/10.1080/00207454.2019.1579718DOI Listing
February 2019

Eyes are mirror of the brain: comparison of multiple sclerosis patients and healthy controls using OCT.

Int J Neurosci 2019 Jan 29:1-8. Epub 2019 Jan 29.

a Department of Ophthalmology , College of Medicine , Abant Izzet Baysal University , Bolu , Turkey.

Objective: To evaluate the thickness of choroid and retinal nerve fiber layer (RNFL) in multiple sclerosis (MS) patients with and without optic neuritis using enhanced depth imaging optical coherence tomography (EDI-OCT).

Methods: In this cross-sectional study, both eyes of 52 MS patients [n = 104 eyes; 62 eyes of MS patients without optic neuritis (MS-NON) and 42 eyes of MS patients with optic neuritis (MS-ON)] and only one eye of 36 healthy control subjects (n = 36 eyes) were evaluated. Complete ophthalmologic examination and EDI-OCT scanning were completed for all participants. Read More

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http://dx.doi.org/10.1080/00207454.2019.1576660DOI Listing
January 2019

hif-1 plays a role in hypoxia-induced gustatory plasticity of Caenorhabditis elegans.

Int J Neurosci 2019 Jan 29:1-8. Epub 2019 Jan 29.

b Department of Biology & Biochemistry , University of Bath , Bath , United Kingdom.

Hypoxia-inducible factor 1 (HIF-1) is a key transcription factor in the detection of low oxygen levels, inducing expression of genes involved in mediating the response to hypoxia to maintain cellular oxygen homeostasis. Caenorhabditis elegans is a soil nematode that has evolved specialized chemosensory neurons that detect changes in oxygen levels and guide its behaviour and responses to food. The role of the hif-1 gene in modifying chemosensory behaviour in response to chemical hypoxia however remains unclear. Read More

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http://dx.doi.org/10.1080/00207454.2019.1576662DOI Listing
January 2019

Osthole alleviates MPTP-induced Parkinson's disease mice by suppressing Notch signaling pathway.

Int J Neurosci 2019 Jan 22:1-9. Epub 2019 Jan 22.

a Department of Neurology, Xuzhou Key Laboratory of Neurobiology , Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University , Xuzhou , China.

Objectives: Parkinson's disease (PD) is an age-related neurodegenerative disease characterized by motor dysfunctions. Dopaminergic neuron loss, inflammation and oxidative stress responses play key roles in the pathogenisis of PD. Osthole (Ost), a natural coumarin derivative, isolated from various herbs such as Cnidium monnieri (L. Read More

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http://dx.doi.org/10.1080/00207454.2019.1573171DOI Listing
January 2019
8 Reads
1.528 Impact Factor

Activation of the Nrf2-ARE signal pathway after blast induced traumatic brain injury in mice.

Int J Neurosci 2019 Jan 16:1-7. Epub 2019 Jan 16.

a Department of Neurosurgery , Jinling Hospital, Jinling School of Clinical Medicine, Nanjing Medical University , Jiangsu , Nanjing , China.

Background: Treatment of blast-induced traumatic brain injury (bTBI) has been hindered. Previous studies have demonstrated that oxidative stress may contribute to the pathophysiological process. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) signaling pathway exhibits a protective effect after traumatic brain injury (TBI). Read More

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http://dx.doi.org/10.1080/00207454.2019.1569652DOI Listing
January 2019
2 Reads

First emerging objective experimental evidence of hearing impairment following subarachnoid haemorrhage; Felix culpa, phonophobia, and elucidation of the role of trigeminal ganglion.

Int J Neurosci 2019 Jan 14:1-7. Epub 2019 Jan 14.

h Department of Neurosurgery , Okmeydanı Training and Research Hospital , Istanbul , Turkey.

Objective: The exact mechanism of phonophobia induced by subarachnoid hemorrhage (SAH) has not been understood well. This subject was investigated.

Material And Methods: This study was conducted on 25 rabbits. Read More

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https://www.tandfonline.com/doi/full/10.1080/00207454.2019.1
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http://dx.doi.org/10.1080/00207454.2019.1569651DOI Listing
January 2019
6 Reads

Exposure to antenatal corticosteroids and reduced respiratory sinus arrhythmia in adult survivors of extremely low birth weight.

Int J Neurosci 2019 Jan 11:1-8. Epub 2019 Jan 11.

a Department of Psychiatry and Behavioural Neurosciences , McMaster University , Hamilton , Canada.

Purpose/aim: Antenatal corticosteroid (ACS) therapy has dramatically increased survival rates among extremely low birth weight (ELBW) infants. However, the long-term effects of ACS on autonomic nervous system function have not been explored. Using the world's oldest longitudinally followed cohort of ELBW infants we compared respiratory sinus arrhythmia (RSA) among ELBW survivors whose mothers received ACS (ELBW-S), those who did not (ELBW-NS) and normal birth weight (NBW) controls in their 20 and 30 s. Read More

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http://dx.doi.org/10.1080/00207454.2019.1567511DOI Listing
January 2019

Clinical features of patients with anti-leucine-rich glioma inactivated-1 protein associated encephalitis: a Chinese case series.

Int J Neurosci 2019 Jan 9:1-8. Epub 2019 Jan 9.

a Department of Neurology , Qilu Hospital, Shandong University , Shandong Sheng , China.

Purpose: Antibodies against leucine-rich glioma inactivated 1 (LGI1) are associated with limbic encephalitis and faciobrachial dystonic seizures (FBDS). We present a large series of Han Chinese patients for further clinical refinement.

Materials And Methods: Serum and cerebrospinal fluid samples from patients were tested. Read More

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http://dx.doi.org/10.1080/00207454.2019.1567507DOI Listing
January 2019
2 Reads

Role of hesperidin in P2X3 receptor-mediated neuropathic pain in the dorsal root ganglia.

Int J Neurosci 2019 Jan 9:1-10. Epub 2019 Jan 9.

c Department of Physiology , Medical School of Nanchang University , Nanchang , PR China.

Aim: This study investigated whether the neuronal P2X3 receptor in rat dorsal root ganglia (DRG) mediated the effects of hesperidin on neuropathic pain.

Materials And Methods: The chronic constriction injury (CCI) model was used as a model of neuropathic pain. The mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured. Read More

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http://dx.doi.org/10.1080/00207454.2019.1567512DOI Listing
January 2019

A technical concept of a computer game for patients with Parkinson's disease - a new form of PC-based physiotherapy.

Int J Neurosci 2019 Jan 9:1-6. Epub 2019 Jan 9.

b University Leipzig, Faculty of Medicine , Department of Neurosurgery , Leipzig , Germany.

Background: At present, there are no meaningful and sophisticated computer games that simultaneously allow the treatment of movement disorders such as Parkinson's syndrome. In particular, there are no systems to consider the severity of the disease and the physical skills of the patient.

Methods: A computer game using the Microsoft Kinect as markerless sensor for the 3 D recognition of the patient's movement was developed to support the rehabilitation. Read More

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http://dx.doi.org/10.1080/00207454.2019.1567510DOI Listing
January 2019
1 Read

Primary culture of mouse embryonic spinal cord neurons: cell composition and suitability for axonal regeneration studies.

Int J Neurosci 2019 Jan 9:1-8. Epub 2019 Jan 9.

a National Research Center Kurchatov Institute , Moscow , Russian Federation.

Objective: Primary culture is an effective experimental model to study molecular mechanisms that drive axonal regeneration after central nervous system injury. However, the culture of spinal cord (SC) cells remains poorly characterized. Here, we have analyzed the cell composition of a primary SC culture during its maturation. Read More

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http://dx.doi.org/10.1080/00207454.2019.1567508DOI Listing
January 2019

Motor imagery in stroke patients: a descriptive review on a multidimensional ability.

Int J Neurosci 2019 Jan 9:1-12. Epub 2019 Jan 9.

a IRCCS Centro Neurolesi "Bonino-Pulejo" , Department of Neurobioimaging, Messina , Italy.

Purpose/aim: Motor imagery (MI) is the mental representation of a movement without engaging its actual execution. MI shares neuroanatomical correlates with brain motor networks. Neurologic disorders affecting motor skills, such as stroke, have been related to impairments in MI. Read More

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http://dx.doi.org/10.1080/00207454.2019.1567509DOI Listing
January 2019
1 Read

Parkinson's Pain is More Aching and Interfering with Social Life in Caucasians Compared to Indians.

Int J Neurosci 2019 Jan 7:1-11. Epub 2019 Jan 7.

g James Cook University , Faculty of Medicine and Dentistry.

Objectives: Although there have been numerous studies conducted to better understand Parkinson's disease (PD), the epidemiology of its debilitating non-motor symptoms across different ethnicities remains understudied. Herein we explore the relationship between depression, anxiety and pain in PD patients of Caucasian or Indian ethnicity (PD Caucasians and PD Indians).

Patients And Methods: All patients and healthy age and gender matched controls were assessed via semi-structured interviews for anxiety, pain, and depression using structured questionnaires. Read More

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http://dx.doi.org/10.1080/00207454.2019.1566232DOI Listing
January 2019

Prospective memory impairment in patients with white matter lesions.

Int J Neurosci 2019 Jan 7:1-9. Epub 2019 Jan 7.

a Department of Neurology , The First Affiliated Hospital of Anhui Medical University , Hefei , Anhui Province , China.

Objective: A vast majority of the episodic memory literature in white matter lesions (WML) had focused on "retrospective memory (RM)", little was known about prospective memory (PM) in WML patients. The aim of our study was to investigate the effect of WML patients on event-based prospective memory (EBPM) and time-based prospective memory (TBPM). In addition, our study attempted to understand the possible mechanisms of PM damage in WML patients. Read More

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http://dx.doi.org/10.1080/00207454.2018.1538988DOI Listing
January 2019
2 Reads

FoxO3 transcription factor promotes autophagy after transient cerebral ischemia/reperfusion.

Int J Neurosci 2018 Dec 31:1-8. Epub 2018 Dec 31.

b Basic Medical Research Centre, Medical School , Nantong University , Nantong , People's Republic of China.

Aim: Autophagy was activated after cerebral ischemia reperfusion (I/R) injury. However, the molecular mechanisms underlying regulation of autophagy in cerebral I/R injury were not completely understood. Studies reported that Forked-box class O (FoxO) transcription factors involved in autophagy and might be the regulator of autophagy in multiple cells. Read More

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http://dx.doi.org/10.1080/00207454.2018.1564290DOI Listing
December 2018

Postoperative cognitive dysfunction and the possible underlying neurodegenerative effect of anaesthesia.

Int J Neurosci 2018 Dec 27:1-9. Epub 2018 Dec 27.

d Department of Clinical and Chemical Pathology , Beni-Suef University , Beni-Suef , Egypt.

Introduction: There is alarming evidence about the involvement of general anaesthesia in the development of postoperative cognitive dysfunction.

Aim: To clarify the impact of general anaesthesia on cognitive function and to study the possible effect of general anaesthesia on serum S100B, the marker of neuronal degeneration.

Methods: This is a prospective randomised controlled study carried out on 50 patients undergoing elective laparoscopic cholecystectomy under conventional general anaesthesia. Read More

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https://www.tandfonline.com/doi/full/10.1080/00207454.2018.1
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http://dx.doi.org/10.1080/00207454.2018.1561451DOI Listing
December 2018
2 Reads

Isolated brainstem involvement in posterior reversible encephalopathy syndrome: a case report and review of the literature.

Int J Neurosci 2018 Dec 27:1-6. Epub 2018 Dec 27.

a Department of Neurology, Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , China.

Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiological syndrome, reversible vasogenic edema predominantly within parieto-occipital regions. However, isolated brainstem involvement in PRES has been rarely reported, little is known about its clinical manifestations, radiological features and outcomes. We reported a case with PRES with only brainstem involvement and performed a systematic review of published cases. Read More

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http://dx.doi.org/10.1080/00207454.2018.1561452DOI Listing
December 2018

Effect of teriparatide use on bone mineral density and spinal fusion: a narrative review of animal models.

Int J Neurosci 2018 Dec 27:1-7. Epub 2018 Dec 27.

c Department of Orthopaedic Surgery , Mayo Clinic , Rochester , MN , USA.

Purpose Of The Study: Teriparatide (Human recombinant Parathyroid Hormone 1-34) is an anabolic agent that is frequently used in patients with osteoporosis and has been extensively investigated with animal model and clinical studies in current literature. The purpose of the study was to evaluate the impact of teriparatide on bone mineral density and fusion.

Materials And Methods: The findings from preclinical studies that have investigated the role of teriparatide in animal models are summarized in presented review. Read More

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http://dx.doi.org/10.1080/00207454.2018.1564051DOI Listing
December 2018
1 Read

The Effect of Serotonin on Penicillin-induced Epileptiform Activity.

Int J Neurosci 2018 Dec 7:1-14. Epub 2018 Dec 7.

c Department of Physiology, Faculty of Medicine , Ondokuz Mayıs University , Samsun , Turkey , e-mail:

This study was aimed at examining the epileptiform activity of the 5-HT serotonin receptor agonist and antagonist, and 5-hydroxytryptophan (5-HTP) in penicillin-induced epilepsy in albino Wistar rats. For this purpose, 90 albino male Wistar rats were used in this study. Epileptiform activity was induced by an injection of penicillin, an agonist of GABAA receptor, (500 IU, ic) into the somatomotor cortex. Read More

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http://dx.doi.org/10.1080/00207454.2018.1557166DOI Listing
December 2018
1 Read

Estimation of skeletal muscle mass in patients with spinocerebellar ataxia type 3 and 10.

Int J Neurosci 2018 Dec 7:1-5. Epub 2018 Dec 7.

f Department of Medicine , Faculdades Pequeno Príncipe , Curitiba , PR , Brazil.

Background: Neurodegenerative diseases may progress to a level in which patients present spontaneous weight loss, resulting in increased falls and functional disabilities when the disease is associated with muscle mass depletion.

Objective: Evaluate the muscle compartment in patients presenting spinocerebellar ataxia (SCA) type 3 and 10.

Methods: Forty-six patients presenting SCA type 3 and 10 were assessed and 76 volunteers were selected to the control group. Read More

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http://dx.doi.org/10.1080/00207454.2018.1557167DOI Listing
December 2018
1 Read

Protective mechanism of Wnt4 gene on Parkinson's disease (PD) transgenic Drosophila.

Int J Neurosci 2018 Dec 11:1-12. Epub 2018 Dec 11.

d Basic Medical College, Guilin Medical University , Guilin , China.

Objective: The main pathological change of Parkinson's disease (PD) is progressive degeneration and necrosis of dopaminergic neurons in the midbrain, forming a Lewy body in many of the remaining neurons. Studies have found that in transgenic Drosophila, mutations in the PTEN-inducible kinase 1 (PINK1) gene may cause indirect flight muscle defects in Drosophila, and mitochondrial structural dysfunction as well.

Methods: In this study, Wnt4 gene overexpression and knockdown were performed in PINK1 mutant PD transgenic Drosophila, and the protective effect of Wnt4 gene on PD transgenic Drosophila and its possible mechanism were explored. Read More

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http://dx.doi.org/10.1080/00207454.2018.1557168DOI Listing
December 2018
1 Read

Anaplastic oligodendroglioma metastasizing to the bone marrow: a unique case report and literature review.

Int J Neurosci 2018 Dec 11:1-7. Epub 2018 Dec 11.

c Baptist Health , Louisville , KY , USA.

Oligodendrogliomas are a rare type of primary brain tumor. They are genetically defined as diffuse gliomas carrying mutation in isocitrate dehydrogenase type 1 (IDH1) or type 2 (IDH2) and codeletion of chromosomes 1p and 19q. The WHO grading system distinguishes two histopathologic grades of ODs: grade II (low-grade) and grade III (anaplastic oligodendroglioma or AO). Read More

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http://dx.doi.org/10.1080/00207454.2018.1557165DOI Listing
December 2018
3 Reads

Perampanel in patients with brain tumour-related epilepsy in real-life clinical practice: a retrospective analysis.

Int J Neurosci 2018 Dec 3:1-10. Epub 2018 Dec 3.

e Biostatistic Unit, Regina Elena National Cancer Institute , Rome , Italy.

Introduction: Epilepsy occurs in 35-70% of patients with gliomas; glutamate plays a central role via AMPA-receptor activation, which is involved both in seizure activity and tumor growth. We conducted a retrospective study on brain tumour-related epilepsy patients (BTRE) treated with perampanel in add-on (PER) for 12 months, to evaluate efficacy and tollerability, according to real-life clinical practice.

Materials And Methods: Medical records of eleven patients (9 males, mean age 54 years) with glioma and epilepsy treated with PER in add-on, for inadequate seizure control or adverse events (AEs) from previous antiepileptic drugs (AEDs) therapy, were reviewed. Read More

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http://dx.doi.org/10.1080/00207454.2018.1555160DOI Listing
December 2018
6 Reads

Shyness, hormones, and quality of life among adults with schizophrenia.

Int J Neurosci 2018 Dec 5:1-11. Epub 2018 Dec 5.

a Department of Psychology, Neuroscience & Behaviour , McMaster University , Hamilton , Ontario , Canada.

Objective: Although individual differences in personality are known to influence quality of life in individuals with schizophrenia, relatively few studies have attempted to identify putative links underlying this relation.

Methods: Here, we examined associations among temperamental shyness, hormones (ie baseline salivary cortisol and testosterone), and quality of life (QoL) measured in 42 stable outpatient adults with schizophrenia.

Results: We found that baseline cortisol, but not testosterone, moderated the relation between shyness and QoL (ß = 1. Read More

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http://dx.doi.org/10.1080/00207454.2018.1543293DOI Listing
December 2018
6 Reads

Measuring abnormal intrinsic brain activities in patients with retinal detachment using amplitude of low-frequency fluctuation: a resting-state fMRI study.

Int J Neurosci 2018 Nov 30:1-13. Epub 2018 Nov 30.

a Department of Ophthalmology , The First Affiliated Hospital of Nanchang University , Nanchang 330006 , Jiangxi , China.

Objective: The targets of this study was to access the alternations of spontaneous brain activity in RD patients by amplitude of low-frequency fluctuation (ALFF) method and to explore their relationships with clinical behavioral performance.

Methods: 20 patients with RD (6 males and 14 females), and 20 healthy controls (HCs) (6 males and 14 females) were recruited, and were matched in sex and age. All participants finished the functional magnetic resonance imaging (fMRI) scanning. Read More

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http://dx.doi.org/10.1080/00207454.2018.1554657DOI Listing
November 2018
1 Read

Cognitive functions and psychological symptoms in migraine: A study on patients with and without aura.

Int J Neurosci 2018 Nov 29:1-16. Epub 2018 Nov 29.

a IRCCS Centro Neurolesi "Bonino-Pulejo" , Messina.

Migraine is neurological disorder with a complex pathophysiology. We described the neuropsychological profile of 100 migraineurs (50 with visual aura and 50 without aura), in interictal phase, compared to 50 matched healthy controls. A battery of standardized neuropsychological tests was used to assess attention, memory and executive functions. Read More

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http://dx.doi.org/10.1080/00207454.2018.1554658DOI Listing
November 2018

Maternal separation induces long-term changes in mineralocorticoid receptor in rats subjected to chronic stress and treated with tianeptine.

Int J Neurosci 2018 Nov 28:1-28. Epub 2018 Nov 28.

a Laboratorio de Fisiología Animal, Facultad de Ciencias Exactas, Físicas y Naturales ; Universidad Nacional de Córdoba , Av. Vélez Sarsfield 299 , Córdoba , Argentina . Postal code : 5000 , Argentina . Tel : + int . 239. Fax: +.

Purpose: The aim of this study was to analyze whether early maternal separation would result in long-term, persistent alterations in stress response in adulthood, altering mineralocorticoid receptor immunoreactivity (MR-ir) in the dorsal hippocampal areas [CA1, CA2, CA3 and dentate gyrus (DG)], paraventricular nucleus of the hypothalamus and medial and central nucleus of the amygdala, key structures involved in stress response regulation. We also analyzed whether chronic treatment with the antidepressant tianeptine reverses these possible changes.

Material And Methods: Male Wistar rats were subjected to daily maternal separation for 4. Read More

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http://dx.doi.org/10.1080/00207454.2018.1550398DOI Listing
November 2018
1 Read

Effects of Stimulus-Related Variables on Mental States Recognition in Huntington'S Disease.

Int J Neurosci 2018 Nov 27:1-21. Epub 2018 Nov 27.

b Huntington and Rare Diseases Unit at IRCCS Casa Sollievo della Sofferenza Hospital (Rome CSS-Mendel) , San Giovanni Rotondo , Italy.

Background: Cognitive abnormalities in Huntington's Disease (HD) can involve the specific impairment of the social perspective taking as well as difficulties in recognizing others' mental state many years before the onset of motor symptoms.

Aims: At the scope of assessing how the difficulties in mental state recognition might be an HD early sign before motor symptoms appear, our study was aimed to investigate how the recognition of others' mental states in HD subjects is moderated by different stimulus related features (gender, difficulty (low, medium, high) and valence (positive, negative, neutral) of the mental states that are to be recognized).

Methods: Subjects with pre-manifest (n = 20) and manifest (n = 40) HD performed the revised "Reading the Mind in the Eyes Test" and were compared with age-matched healthy controls (HC, 40 subjects per cohort). Read More

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http://dx.doi.org/10.1080/00207454.2018.1552691DOI Listing
November 2018
14 Reads

Adult Convulsive status epileptic us: clinical, etiological and predictors of outcome study from rural population of North India.

Int J Neurosci 2018 Nov 26:1-22. Epub 2018 Nov 26.

d Forensic Medicine & Toxicology, UP university of medical sciences , Saifai, Etawah - 206301 ( U.P. ) India

Aim: To determine the clinical profile, aetiologies and predictors of mortality in patients with convulsive status epilepticus (CSE) among rural population of North India in view of limited published data on epidemiology and aetiology of status epilepticus (SE) from developing countries.

Methods: 162 consecutive adult patients with CSE were evaluated from 2016 to 2018 for demographic profile, aetiologies and predictors of poor outcome.

Results: The mean age was 41. Read More

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https://www.tandfonline.com/doi/full/10.1080/00207454.2018.1
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http://dx.doi.org/10.1080/00207454.2018.1552692DOI Listing
November 2018
10 Reads

Morphological consequences of acoustic trauma on cochlear hair cells and the auditory nerve.

Int J Neurosci 2018 Nov 26:1-16. Epub 2018 Nov 26.

a CILcare. 2214, Boulevard de la Lironde. Parc Scientifique Agropolis . Montpellier. France.

Hearing loss is the most common form of sensory impairment in humans. Noise exposure is responsible for around 10% of hearing loss in adults. Short impulses of a high intensity noise, such as a gunshot or explosion, can trigger sudden hearing loss, which is generally irreversible and associated with structural tissue damage of the cochlea and auditory nerve. Read More

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http://dx.doi.org/10.1080/00207454.2018.1552693DOI Listing
November 2018
1 Read

An elderly patient with Alzheimer's Disease, Normal Pressure Hydrocephalus and Traumatic Brain Injury: presented with behavioral symptoms similar to behavioral variant Frontotemporal Dementia.

Int J Neurosci 2018 Nov 26:1-8. Epub 2018 Nov 26.

a Department of Geriatric Medicine , Dokuz Eylul University , Faculty of Medicine , Izmir , Turkey.

Traumatic brain injury (TBI) is nondegenerative insult to brain from external mechanical forces. It may cause cognitive impairment, psychological problems in the long period. Besides traumatic brain injury also induces neuroinflammation and neurodegeneration process, and increases risk of dementia. Read More

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http://dx.doi.org/10.1080/00207454.2018.1552690DOI Listing
November 2018
23 Reads

Edaravone inhibits autophagy after neuronal oxygen-glucose deprivation/recovery injury.

Int J Neurosci 2018 Nov 25:1-26. Epub 2018 Nov 25.

b Department of Orthopaedics , The First Affiliated Hospital With Nanjing Medical University , Nanjing 210029 , China.

Edaravone is an oxygen free radical scavenger that is widely used to treat ischemic injury to the nervous system. The present study investigated the effect of edaravone pretreatment on neurons subjected to oxygen-glucose deprivation/recovery (OGD/R) injury. Common neurons were subjected to oxygen and glucose deprivation for 1 h, followed by oxygen and glucose recovery for 0. Read More

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http://dx.doi.org/10.1080/00207454.2018.1550399DOI Listing
November 2018
1 Read
1.528 Impact Factor

Not All Clots Are Created Equal: A Review of Deficient Thrombolysis with Tissue Plasminogen Activator (tPA) in Patients with Metabolic Syndrome.

Int J Neurosci 2018 Nov 22:1-18. Epub 2018 Nov 22.

c Department of Physiology, Pharmacology & Neuroscience , West Virginia University.

Metabolic syndrome is a cluster of cardiovascular risk factors associated with a prothrombotic, proinflammatory and hypofibrinolysis state. Although resistance to tissue plasminogen activator (tPA) in metabolic syndrome patients has been associated with a defective fibrinolytic system, the factors and mechanisms underlining such resistance is unclear. While there is a great debate on proposed mechanisms, fundamental questions regarding resistance to tPA in metabolic syndrome patients with ischemic stroke remain unanswered. Read More

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http://dx.doi.org/10.1080/00207454.2018.1550400DOI Listing
November 2018
11 Reads

Neurogenesis in the Adult Hippocampus: History, Regulation, and Prospective Roles.

Int J Neurosci 2018 Nov 15:1-24. Epub 2018 Nov 15.

a Neuroscience Research Center , Faculty of Medical Sciences , Lebanese University , Beirut , Lebanon.

The hippocampus is one of the sites in the mammalian brain that is capable of continuously generating controversy. Adult neurogenesis is a remarkable process, and yet an intensely debatable topic in contemporary neuroscience due to its distinctiveness and conceivable impact on neural activity. The belief that neurogenesis continues through adulthood has provoked remarkable efforts to describe how newborn neurons differentiate and incorporate into the adult brain. Read More

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http://dx.doi.org/10.1080/00207454.2018.1545771DOI Listing
November 2018
1.530 Impact Factor

Neuro protective effect of Naringenin against MPTP induced oxidative stress.

Int J Neurosci 2018 Nov 15:1-7. Epub 2018 Nov 15.

c Department of Biotechnology , Dr. M.G.R. Educational and Research Institute , Chennai - 600 095, Tamil Nadu , India.

Background: Parkinson's disease is the most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in substantia nigra and depletion of dopamine in striatum due to excitotoxicity, oxidative stress and many other factors may contribute to MPTP- and PD-related neurodegeneration. The present study deals with the neuroprotective effect of Naringenin (NGN), a bioflavonoid against MPTP induced Parkinson's disease in the mouse model.

Methods: Healthy male C57BL/6J mice (18-22 g b wt) were pretreated with NGN [25, 50,100 mg/kg/b. Read More

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http://dx.doi.org/10.1080/00207454.2018.1545772DOI Listing
November 2018
11 Reads
1.530 Impact Factor

Pretraining hippocampal stimulation of melatonin type 2 receptors can improve memory acquisition in rats.

Int J Neurosci 2018 Nov 15:1-9. Epub 2018 Nov 15.

a Neurophysiology Research Center , Hamadan University of Medical Science , Hamadan , Iran.

Background: Learning and memory are among the most important cognitive functions of the brain. Melatonin receptor type 2 (MT2R) is located in the hippocampus and participates in learning and memory processes. In the present study, we examined the role of hippocampal MT2R activation in the acquisition, consolidation, and retrieval of learning and memory in novel object recognition (NOR) and passive avoidance (PA) tasks. Read More

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http://dx.doi.org/10.1080/00207454.2018.1545770DOI Listing
November 2018

A case of fatal invasive aspergillosis in a patient with neurosarcoidosis treated with infliximab.

Int J Neurosci 2018 Nov 15:1-4. Epub 2018 Nov 15.

a Department of Neurology and Rehabilitation Medicine , University of Cincinnati , Cincinnati , OH , USA.

Introduction: CNS involvement in sarcoidosis is seen in 5-10% of cases. Long term treatment involves steroids and other immunomodulatory agents, including infliximab. Chronic immunosuppression can result in increased patient susceptibility to opportunistic infections. Read More

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http://dx.doi.org/10.1080/00207454.2018.1544130DOI Listing
November 2018
5 Reads
1.530 Impact Factor

Protective effects of glucagon-like peptide-1 (GLP-1) analogue exenatide against glucose and fructose-induced neurotoxicity.

Int J Neurosci 2018 Nov 13:1-24. Epub 2018 Nov 13.

a Department of Physiology , Ege University School of Medicine , Bornova-Izmir.

Diabetes mellitus (DM) is one of the most common metabolic disorders characterized by hyperglycemia due to insufficiency of insulin and/or insulin resistance. Clinical studies have revealed a higher risk of neurodegenerative disorders such as Alzheimer's disease or Parkinson's disease in diabetic patients. Recently, glucagon-like peptide-1 (GLP-1) is an attractive potential treatment modality for various neurodegenerative diseases. Read More

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https://www.tandfonline.com/doi/full/10.1080/00207454.2018.1
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http://dx.doi.org/10.1080/00207454.2018.1543671DOI Listing
November 2018
17 Reads

Computational investigation of mechanistic insights of Aβ42 interactions against extracellular domain of nAChRα7 in Alzheimer's disease .

Int J Neurosci 2018 Nov 13:1-39. Epub 2018 Nov 13.

a Department of Biological Sciences , College of Natural Sciences, Kongju National University , Gongjudehak-Ro 56 , Gongju , Chungnam-do 32588 , Republic of Korea.

Amyloid beta (Aβ) 1-42, which is a basic constituent of amyloid plaques, binds with extracellular transmembrane receptor nicotine acetylcholine receptor α7 (nAChRα7) in Alzheimer's disease. In the current study, a computational approach was employed to explore the active binding sites of nAChRα7 through Aβ 1-42 interactions and their involvement in the activation of downstream signaling pathways. Sequential and structural analyses were performed on the extracellular part of nAChRα7 to identify its core active binding site. Read More

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November 2018
12 Reads

The spectrum of SDHD mutations in Russian patients with head and neck paraganglioma.

Int J Neurosci 2018 Dec 30;128(12):1174-1179. Epub 2018 Oct 30.

a Department of Molecular Bases of Human Genetics , Institute of Molecular Genetics, Russian Academy of Sciences , Moscow , Russia.

Aim Of The Study: It was found that the mutations in the SDHD gene, encoding one of subunits of the succinate dehydrogenase complex, lead to the development of head and neck paraganglioma (HNPGL). We analyzed this gene in 91 patients with HNPGL from Russia.

Materials And Methods: DNA was isolated from the whole blood. Read More

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http://dx.doi.org/10.1080/00207454.2018.1503181DOI Listing
December 2018
3 Reads

Construction of a novel Chinese normal brain database using F-FDG PET images and MIMneuro software, the initial application in epilepsy.

Int J Neurosci 2018 Oct 30:1-22. Epub 2018 Oct 30.

a Department of Radiology , the First Affiliated Hospital of Xi'an Jiaotong University , Xi'an 710061 , Shanxi , China.

Purpose: To create a standard Western Chinese normal functional brain database for quantitative analysis using 2-deoxy-2-[18F] fluoro-D-glucose (F-FDG) positron emission tomography (PET) images and MIMneuro software.

Methods: 78 healthy right-handed Chinese volunteers from Tangdu Hospital were scanned using F-FDG PET to evaluate brain metabolism between March and October 2016. All PET images were processed using MIMneuro software to create a normal database platform. Read More

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http://dx.doi.org/10.1080/00207454.2018.1538138DOI Listing
October 2018
1 Read

Predictors of poor cerebral collaterals and cerebrovascular reserve in patients with chronic total carotid occlusion.

Int J Neurosci 2018 Oct 29:1-6. Epub 2018 Oct 29.

a Department of Neurology , Cairo University, Cairo , Egypt.

Background: This study aims to investigate the relationship between cerebrovascular reserve (CVR) capacity, as measured by single-photon emission computed tomography (SPECT) and collateral blood flow, according to a transcranial colour-coded duplex(TCCD), in patients with symptomatic total carotid occlusion (TCO). Additionally, the study aims to determine whether vascular risk factors have an effect on collateral blood flow, as well as on the CVR.

Methods: Thirty-four patients with chronic TCO, diagnosed by carotid duplex scanning and confirmed by other vascular imaging modalities, who had ischaemic symptoms either as stroke or transient ischaemic attack, were subjected to clinical assessment, SPECT under dipyridamole stress, and grading of cerebral collateral blood flow using TCCD. Read More

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http://dx.doi.org/10.1080/00207454.2018.1538990DOI Listing
October 2018
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Genetics of platelet traits in ischaemic stroke: focus on mean platelet volume and platelet count.

Int J Neurosci 2018 Oct 29:1-12. Epub 2018 Oct 29.

a Department of Human Genetics and Molecular Medicine , Central University of Punjab Bathinda , Punjab , India.

Purpose/Aim of the study: The aim of this review is to summarize the role of genetic variants affecting mean platelet volume (MPV) and platelet count (PLT) leading to higher platelet reactivity and in turn to thrombotic events like stroke and cardiovascular diseases.

Materials And Methods: A search was conducted in PUBMED, MEDLINE, EMBASE, PROQUEST, Science Direct, Cochrane Library, and Google Scholar related to the studies focussing on genome-wide association studies (GWAS), whole exome sequencing (WES), whole genome sequencing (WGS), phenome-wide association studies (PheWAS) and multi-omic analysis that have been employed to identify the genetic variants influencing MPV and PLT.

Results: Antiplatelet agents underscore the crucial role of platelets in the pathogenesis of stroke. Read More

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http://dx.doi.org/10.1080/00207454.2018.1538991DOI Listing
October 2018
6 Reads
1.530 Impact Factor

Role of P38 Mitogen-Activated Protein Kinase on Cx43 Phosphorylation in Cerebral Vasospasm after Subarachnoid Hemorrhage.

Int J Neurosci 2018 Oct 27:1-26. Epub 2018 Oct 27.

a Department of Neurosurgery , First Affiliated Hospital of Medical College, Shihezi University , Xinjiang , China.

Objectives: Cx43 phosphorylation is involved in the pathogenesis of cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH). However, the exact phosphorylation mechanism of Cx43 in CVS is not fully elucidated. Thus, we examined the role of P38MAPK in CVS and Cx43 phosphorylation, using a double hemorrhage rat model. Read More

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http://dx.doi.org/10.1080/00207454.2018.1538992DOI Listing
October 2018
10 Reads

Prior malignancy impact on survival outcomes of glioblastoma multiforme; population-based study.

Int J Neurosci 2018 Oct 26:1-23. Epub 2018 Oct 26.

d Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Experimental Ophthalmology, Department of Ophthalmology, Campus Virchow Klinikum , Berlin , Germany.

Background: Glioblastoma multiforme (GBM) patients with a prior malignancy are usually excluded from clinical trials on GBM based on the assumption that this history will affect their survival outcomes. This practice may affect clinical trial accrual and limit the gathering of knowledge essential to the formulation of therapeutic options for this patient population. However, not much is known about the real impact of these prior malignancies on the survival of patients with subsequent GBM. Read More

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http://dx.doi.org/10.1080/00207454.2018.1538989DOI Listing
October 2018
15 Reads

Pharmacogenetics and levodopa induced motor complications.

Int J Neurosci 2018 Oct 25:1-31. Epub 2018 Oct 25.

a Department of General Biology , Medical School, Aristotle University of Thessaloniki , Thessaloniki , Greece.

Parkinson's disease (PD) is a complex, heterogenous neurodegenerative disorder, characterized by a progressive loss of dopaminergic neurons. L-dopa remains the most effective symptomatic therapy for PD but unfortunately, its chronic use is often associated with motor complications. PD patients show remarkable heterogeneity in their response to L-dopa and this profound interindividual heterogeneity suggests that there is a genetic predisposition. Read More

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http://dx.doi.org/10.1080/00207454.2018.1538993DOI Listing
October 2018

Superior sagittal sinus thrombosis as a rare complication of spontaneous intracranial hypotension syndrome: a case report and review of the literature.

Int J Neurosci 2018 Nov 29:1-5. Epub 2018 Nov 29.

a Department of Neurology , Shengjing Hospital of China Medical University , Tiexi District , Shenyang , China.

In addition to an orthostatic headache, spontaneous intracranial hypotension syndrome can lead to subdural hematoma and diffusion, subarachnoid hemorrhage, and brain sag. However, cerebral venous sinus thrombosis is rarely reported in patients with spontaneous intracranial hypotension. We present the case of a 35-year-old male who developed an orthostatic headache, nausea, vomiting, and photophobia for 5 days. Read More

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http://dx.doi.org/10.1080/00207454.2018.1538144DOI Listing
November 2018
1 Read