285 results match your criteria International Journal of Nephrology and Renovascular Disease [Journal]


The potential diagnostic utility of coexpression of Ki-67 and P53 in the renal biopsy in pediatric lupus nephritis.

Int J Nephrol Renovasc Dis 2018 12;11:343-350. Epub 2018 Dec 12.

Santa Monica College, Santa Monica, CA, USA.

Background: The proliferative activity as well as apoptosis has been suggested to play a role in the pathogenesis of lupus nephritis (LN). The aim of the study was to investigate the coexpression of Ki-67-triggered marked proliferation and P53-induced apoptosis in renal biopsy of childhood lupus nephritis (cLN) and to compare the coexpression of proliferative and apoptotic indices between different subgroups and clinicopathologic patterns of renal disease.

Methods: Renal biopsy specimens of 33 children with lupus nephritis (LN) and 10 healthy subjects were retrospectively evaluated. Read More

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https://www.dovepress.com/the-potential-diagnostic-utility-o
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http://dx.doi.org/10.2147/IJNRD.S175481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296180PMC
December 2018
6 Reads

Self-management and associated factors among patients with end-stage renal disease undergoing hemodialysis at health facilities in Addis Ababa, Ethiopia.

Int J Nephrol Renovasc Dis 2018 27;11:329-336. Epub 2018 Nov 27.

School of Nursing and Midwifery, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia,

Introduction: Patients with end-stage renal disease (ESRD) face multifaceted problems arising from complications of the disease and dialysis that require consistent and, effective self-management from the patients' side, on top of the management offered by health care professionals. However, little is known about the level of self-management and influencing factors among patients with ESRD undergoing hemodialysis in the study area. Therefore, the aim of this study was to assess self-management and associated factors of patients with ESRD undergoing hemodialysis at health facilities in Addis Ababa, Ethiopia. Read More

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http://dx.doi.org/10.2147/IJNRD.S184671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267502PMC
November 2018

Acute kidney injury among nonagenarians in Jordan: a retrospective case-control study.

Int J Nephrol Renovasc Dis 2018 30;11:337-342. Epub 2018 Nov 30.

Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Background: Improvements in health care systems worldwide have had notable effects on the life expectancy of older individuals. As a result, nonagenarians are emerging as a separate age group with distinct health care needs. The aim of this study was to evaluate the incidence of acute kidney injury (AKI), the mortality rates, and length of in-hospital stay among nonagenarians. Read More

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https://www.dovepress.com/acute-kidney-injury-among-nonagena
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http://dx.doi.org/10.2147/IJNRD.S186121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280911PMC
November 2018
6 Reads

Successful salvage of allograft dysfunction triggered by transplant renal vein thrombosis immediately after kidney transplantation: a case report.

Int J Nephrol Renovasc Dis 2018 23;11:321-327. Epub 2018 Nov 23.

Department of Urology, Nara Medical University, Kashihara, Nara 634-8522, Japan,

Background: Transplant renal vein thrombosis (TRVT) is a severe vascular complication and is caused by various factors, including recipient factors, donor factors, immunosuppression regimens, and surgical techniques. Despite adequate interventions, including thrombolytic therapy or surgical thrombectomy, successful salvage of the allograft is often difficult. We observed a case of TRVT induced by compression of the renal vein immediately after intraoperative abdominal closure. Read More

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http://dx.doi.org/10.2147/IJNRD.S185520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260141PMC
November 2018
2 Reads

Antineutrophil cytoplasmic antibody-associated vasculitis, update on molecular pathogenesis, diagnosis, and treatment.

Int J Nephrol Renovasc Dis 2018 22;11:313-319. Epub 2018 Nov 22.

Department of Medicine, Division of Nephrology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA,

Circulating antineutrophil cytoplasmic antibodies (ANCAs) are the central pathogenic mechanism for a group of systemic and renal syndromes called the ANCA-associated vasculitis (AAV). The nomenclature has changed from eponymous labeling to granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis. These syndromes predominantly affect the pulmonary and renal systems. Read More

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http://dx.doi.org/10.2147/IJNRD.S162071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255047PMC
November 2018
2 Reads

Evaluation of a protocol for coronary artery disease investigation in asymptomatic elderly hemodialysis patients.

Int J Nephrol Renovasc Dis 2018 14;11:303-311. Epub 2018 Nov 14.

Heart Institute (InCor) and Renal Transplant Unit, Division of Urology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, SP, Brazil,

Background: Coronary artery disease (CAD) is prevalent in older patients on dialysis, but the prognostic relevance of coronary assessment in asymptomatic subjects remains undefined. We tested the usefulness of a protocol, based on clinical, invasive, and noninvasive coronary assessment, by answering these questions: Could selecting asymptomatic patients for coronary invasive assessment identify those at higher risk of events? Is CAD associated with a worse prognosis?

Methods: A retrospective study including 276 asymptomatic patients at least 65 years old on the waiting list, prospectively evaluated for CAD and followed up until death or renal transplantation, were classified into two groups: 1) low-risk patients who did not undergo coronary angiography (n=63) and 2) patients who did undergo angiography (n=213). The latter group was reclassified into patients with significant CAD or normal angiograms/nonsignificant CAD. Read More

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http://dx.doi.org/10.2147/IJNRD.S174018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241684PMC
November 2018
3 Reads

Bartter syndrome: causes, diagnosis, and treatment.

Int J Nephrol Renovasc Dis 2018 9;11:291-301. Epub 2018 Nov 9.

Nephrology Division, Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, São Paulo, Brazil,

Bartter syndrome is an inherited renal tubular disorder caused by a defective salt reabsorption in the thick ascending limb of loop of Henle, resulting in salt wasting, hypokalemia, and metabolic alkalosis. Mutations of several genes encoding the transporters and channels involved in salt reabsorption in the thick ascending limb cause different types of Bartter syndrome. A poor phenotype-genotype relationship due to the interaction with other cotransporters and different degrees of compensation through alternative pathways is currently reported. Read More

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https://www.dovepress.com/bartter-syndrome-causes-diagnosis-
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http://dx.doi.org/10.2147/IJNRD.S155397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233707PMC
November 2018
12 Reads

Nocturnal blood pressure decrease in patients with chronic kidney disease and in healthy controls - significance of obstructive sleep apnea and renal function.

Int J Nephrol Renovasc Dis 2018 8;11:279-290. Epub 2018 Nov 8.

University Clinic in Nephrology and Hypertension, Holstebro Hospital and Aarhus University, Holstebro, Denmark,

Background: Chronic kidney disease (CKD) is often associated with a blunted nocturnal BP decrease and OSA. However, it is not fully clear whether a relationship exists between reduction in renal function and obstructive sleep apnea (OSA) on the one hand and relative nocturnal BP decrease in CKD patients on the other. The aim of this study was to investigate the association between nocturnal BP decrease and renal function, the degree of OSA, vasoactive hormones, and renal sodium handling in CKD3-4 patients and healthy age-matched controls. Read More

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http://dx.doi.org/10.2147/IJNRD.S176606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231441PMC
November 2018
2 Reads

Low aquaporin-2 excretion in the nephrotic syndrome: an escape from the vasopressin regulating effect.

Int J Nephrol Renovasc Dis 2018 17;11:271-277. Epub 2018 Oct 17.

Sechenov First Moscow State Medical University, Moscow, Russia,

Purpose: Experimental studies suggest that the nephrotic syndrome is associated with "vasopressin escape", characterized by low aquaporin-2 (AQP2) expression in the collecting duct despite high vasopressin secretion. We investigated this phenomenon in patients with the nephrotic syndrome.

Patients And Methods: We recruited 47 patients with proteinuric kidney disease who were distributed into the following four groups: 1) nephrotic syndrome with kidney dysfunction (n=10); 2) nephrotic syndrome with normal kidney function (n=16); 3) partial remission of nephrotic syndrome (n=10); and 4) minimal proteinuria (n=11). Read More

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https://www.dovepress.com/low-aquaporin-2-excretion-in-the-n
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http://dx.doi.org/10.2147/IJNRD.S177469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198888PMC
October 2018
6 Reads

Renal transplantation in patients with Alport syndrome: patient selection, outcomes, and donor evaluation.

Int J Nephrol Renovasc Dis 2018 16;11:267-270. Epub 2018 Oct 16.

Division of Nephrology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55454, USA,

Alport syndrome is an inherited disorder of basement membrane collagen IV that frequently results in end-stage renal disease. Patients with Alport syndrome who undergo renal transplantation have generally excellent outcomes. Posttransplant antiglomerular basement membrane nephritis is a rare complication of renal transplantation for Alport syndrome. Read More

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https://www.dovepress.com/renal-transplantation-in-patients-
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http://dx.doi.org/10.2147/IJNRD.S150539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198874PMC
October 2018
7 Reads

Serial changes in vessel walls of renal arteries after catheter-based renal artery denervation: insights from volumetric computed tomography analysis.

Int J Nephrol Renovasc Dis 2018 27;11:259-266. Epub 2018 Sep 27.

Department of Medicine, Cardiovascular Research Center, Royal Adelaide Hospital, University of Adelaide, Adelaide, SA, Australia,

Aim: Radiofrequency ablation of peri-arterial renal autonomic nerves has been studied as a potential therapeutic option for resistant hypertension. While recent clinical trials have reported its efficacy, there is paucity of data addressing the effects of the procedure on renal arteries, such as changes in vessel and lumen areas. Herein, the effect of atheroma burden on renal arteries after renal denervation was assessed using computed tomography (CT) imaging. Read More

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http://dx.doi.org/10.2147/IJNRD.S161313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166743PMC
September 2018
11 Reads

Renal replacement therapy in patients with acute respiratory distress syndrome: a single-center retrospective study.

Int J Nephrol Renovasc Dis 2018 26;11:249-257. Epub 2018 Sep 26.

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, The University of Arizona, Tucson, AZ, USA.

Background: Patients with acute respiratory distress syndrome (ARDS) who develop acute kidney injury have increased mortality and frequently require renal replacement therapy (RRT). The optimal timing for initiation of RRT after onset of ARDS to improve survival is not known.

Methods: We retrospectively reviewed clinical data on patients admitted to our health system over a 2-year period. Read More

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https://www.dovepress.com/renal-replacement-therapy-in-patie
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http://dx.doi.org/10.2147/IJNRD.S164628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163023PMC
September 2018
3 Reads

Clinical value of a serum anti-PLA2R antibody in the diagnosis and monitoring of primary membranous nephropathy in adults.

Int J Nephrol Renovasc Dis 2018 20;11:241-247. Epub 2018 Sep 20.

Department of Physiology, Bengbu Medical College, Bengbu, Anhui, People's Republic of China,

Objective: To compare the positive rate of anti-PLA2R antibodies in patients with primary membranous nephropathy (PMN), secondary membranous nephropathy (SMN), and non-membrane nephropathy (non-MN); evaluate serum anti-PLA2R antibodies in the diagnosis of PMN; quantify the serum anti-PLA2R antibody levels during the treatment of PMN patients; and evaluate the clinical value of monitoring changes in serum anti-PLA2R antibody quantification levels.

Methods: The kidney tissue was collected by kidney biopsy. The expression of PLA2R in glomeruli was detected by immunofluorescence, and ELISA was used to quantify the serum anti-PLA2R antibody. Read More

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http://dx.doi.org/10.2147/IJNRD.S176665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159797PMC
September 2018

Effects of tolvaptan on renal function in chronic kidney disease patients with volume overload.

Int J Nephrol Renovasc Dis 2018 17;11:235-240. Epub 2018 Aug 17.

Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan,

Background: Fluid overload in chronic kidney disease (CKD) is generally controlled by diuretics, with potentially harmful effects on renal function. The efficacy of tolvaptan, a vasopressin V2-receptor antagonist and aquaretic, has not been evaluated for fluid control in CKD with reduced renal function.

Methods: Each patient from a group of 24 CKD patients on tolvaptan 15 mg/d plus conventional diuretics (T group) was matched by age and sex with a patient from a group of 24 CKD patients on conventional nonaquaretic diuretics alone not associated to tolvaptan other than tolvaptan (C group). Read More

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http://dx.doi.org/10.2147/IJNRD.S167694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103308PMC
August 2018
12 Reads

Takayasu's disease effects on the kidneys: current perspectives.

Int J Nephrol Renovasc Dis 2018 15;11:225-233. Epub 2018 Aug 15.

Nephrology, Dialysis and Renal Transplant Department, Civico and Di Cristina Hospital, Palermo, Italy,

Takayasu arteritis (TA) is a chronic vasculitis disease of unknown etiology. Clinically significant renal disease is relatively common, and renovascular hypertension is the major renal problem. The assessment of TA activity is usually challenging because vascular inflammation may progress to fixed vascular injury without findings of active disease. Read More

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http://dx.doi.org/10.2147/IJNRD.S146355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101009PMC
August 2018
2 Reads

Acute kidney injury in elderly patients: narrative review on incidence, risk factors, and mortality.

Int J Nephrol Renovasc Dis 2018 14;11:217-224. Epub 2018 Aug 14.

Botucatu School of Medicine, São Paulo State University (UNESP), Sao Paulo, Brazil,

Acute kidney injury (AKI) is characterized by a sudden renal dysfunction with consequent increase of nitrogenous products, hydroelectrolytic and acid-base disorders. Its prevalence is high in hospitalized populations (4.9%-7. Read More

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https://www.dovepress.com/acute-kidney-injury-in-elderly-pat
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http://dx.doi.org/10.2147/IJNRD.S170203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097506PMC
August 2018
17 Reads

Inflammatory milieu in contrast-induced nephropathy: a prospective single-center study.

Int J Nephrol Renovasc Dis 2018 13;11:211-215. Epub 2018 Aug 13.

Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Background: Acute kidney injury (AKI) caused by contrast exposure is a common problem, which may cause a significant increase in patients in-hospital stay and therefore the cost of treatment. This study was conducted to evaluate the role of inflammation, inflammatory markers in predicting contrast induced nephropathy (CIN). This is a prospective study that was carried out in a major tertiary referral hospital in Jordan. Read More

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http://dx.doi.org/10.2147/IJNRD.S171930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095120PMC
August 2018
13 Reads

Relationship of inferior vena cava collapsibility to ultrafiltration volume achieved in critically ill hemodialysis patients.

Int J Nephrol Renovasc Dis 2018 23;11:195-209. Epub 2018 Jul 23.

Division of Nephrology, University of Southern California, Los Angeles, CA, USA,

Background: Ultrasound (US) assessment of intravascular volume may improve volume management of dialysis patients. We investigated the relationship of intravascular volume evaluated by inferior vena cava (IVC) US to net volume changes with intermittent hemodialysis (HD) in critically ill patients.

Methods: A retrospective cohort of 113 intensive care unit patients in 244 encounters had clinical assessment of intravascular volume followed by US of respiratory/ventilatory variation of IVC diameter, and had HD within 24 h. Read More

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http://dx.doi.org/10.2147/IJNRD.S165744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061398PMC
July 2018
13 Reads

Atherosclerotic vascular disease and its correlates in stable black South African kidney transplant recipients.

Int J Nephrol Renovasc Dis 2018 16;11:187-193. Epub 2018 Jul 16.

Department of Internal Medicine, Division of Nephrology, University of Witwatersrand, Johannesburg, South Africa,

Background: Despite remarkable improvement in renal function attributable to kidney transplantation, the burden of cardiovascular disease (CVD) among kidney transplant recipients (KTRs) remains high in the post-transplant period. Aggressive use of statins in KTRs may make lipoprotein ratios correlate better with atherosclerotic vascular disease (AsVD) when compared with traditional lipid profile parameters. We therefore evaluated the clinical and echocardiographic correlates of AsVD among non-diabetic, stable, black KTRs in South Africa. Read More

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https://www.dovepress.com/atherosclerotic-vascular-disease-a
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http://dx.doi.org/10.2147/IJNRD.S160553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053296PMC
July 2018
6 Reads

Peritoneal dialysis-related peritonitis: challenges and solutions.

Authors:
William L Salzer

Int J Nephrol Renovasc Dis 2018 11;11:173-186. Epub 2018 Jun 11.

School of Medicine, University of Missouri, Columbia, MO, USA.

Peritoneal dialysis is an effective treatment modality for patients with end-stage renal disease. The relative use of peritoneal dialysis versus hemodialysis varies widely by country. Data from a 2004 survey reports the percentage of patients with end-stage renal disease treated with peritoneal dialysis to be 5%-10% in economically developed regions like the US and Western Europe to as much as 75% in Mexico. Read More

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http://dx.doi.org/10.2147/IJNRD.S123618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001843PMC
June 2018
5 Reads

Prevalence of chronic kidney disease in Nigeria: systematic review of population-based studies.

Int J Nephrol Renovasc Dis 2018 22;11:165-172. Epub 2018 May 22.

Division of Nephrology, Department of Internal Medicine, University of Benin Teaching Hospital, Benin City, Nigeria.

Background: The aim of this study was to identify and discuss published population-based studies carried out in Nigeria that have information on the prevalence of chronic kidney disease (CKD) and have also used the Kidney Disease Outcomes Quality Initiative (KDOQI) practice guidelines in defining CKD, with emphasis on the performance of three estimating equations for glomerular filtration rate (GFR) - Modification of Diet in Renal Disease (MDRD), Cock-croft-Gault, and CKD epidemiology collaboration (CKD-EPI) creatinine equation.

Materials And Methods: A systematic literature search was carried out in Google, MEDLINE, PubMed, and AJOL database, with the aim of identifying relevant population-based studies with information on the prevalence of CKD in a location in Nigeria.

Results: Seven cross-sectional population-based studies were identified. Read More

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http://dx.doi.org/10.2147/IJNRD.S162230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968792PMC
May 2018
8 Reads

Smoking and outcomes in kidney transplant recipients: a post hoc survival analysis of the FAVORIT trial.

Int J Nephrol Renovasc Dis 2018 27;11:155-164. Epub 2018 Apr 27.

Kidney and Hypertension Section, Joslin Diabetes Center.

Background: Tobacco use remains an international health problem with between 10% and 40% of adults currently using tobacco. Given the rising number of patients either awaiting or having received a kidney transplant and the absence of smoking cessation as the criterion for transplantation in guidelines, we explored the association between smoking status and clinical outcomes in kidney transplant recipients.

Patients And Methods: In this post hoc analysis of the Folic Acid for Vascular Outcome Reduction in Transplant trial, the associations between smoking status, defined as never having smoked, formerly or currently smoking, and both all-cause mortality and graft survival were assessed using Cox proportional hazards models. Read More

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http://dx.doi.org/10.2147/IJNRD.S161001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937486PMC
April 2018
4 Reads

Prediction of acute kidney injury in cirrhotic patients: a new score combining renal, liver and inflammatory markers.

Int J Nephrol Renovasc Dis 2018 24;11:149-154. Epub 2018 Apr 24.

Division of Nephrology and Renal Transplantation, Department of Medicine, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Introduction: Acute kidney injury (AKI) is common in hospitalized patients with cirrhosis and is associated with poor prognosis. A risk prediction score combining values easily measured at admission could be valuable to stratify patients for prevention, monitoring and early intervention, ultimately improving patient care and outcomes. The aim of this study was to develop a risk score for AKI in a cohort of cirrhotic patients. Read More

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http://dx.doi.org/10.2147/IJNRD.S163602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923222PMC
April 2018
6 Reads

Primary IgA nephropathy: current challenges and future prospects.

Int J Nephrol Renovasc Dis 2018 12;11:137-148. Epub 2018 Apr 12.

Renal and Vascular Inflammation Section, Department of Medicine, Imperial College London, London, UK.

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, exhibiting a variable clinical and pathological course and significantly contributing to the global burden of chronic kidney disease and end-stage renal disease. Current standards of care focus on optimization of antihypertensive and antiproteinuric therapies (typically renin- angiotensin system blockade) to reduce disease progression. Much recent attention has focused on whether additional immunosuppression confers better outcomes than supportive management alone, and indeed, several trials have demonstrated renoprotective effects following the use of oral corticosteroids. Read More

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http://dx.doi.org/10.2147/IJNRD.S129227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905843PMC
April 2018
1 Read

FGF23 modulates the effects of erythropoietin on gene expression in renal epithelial cells.

Int J Nephrol Renovasc Dis 2018 4;11:125-136. Epub 2018 Apr 4.

Department of Nephrology, Wakayama Medical University, Wakayama, Japan.

Background: FGF23 plays an important role in calcium-phosphorus metabolism. Other roles of FGF23 have recently been reported, such as commitment to myocardium enlargement and immunological roles in the spleen. In this study, we aimed to identify the roles of FGF23 in the kidneys other than calcium-phosphorus metabolism. Read More

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http://dx.doi.org/10.2147/IJNRD.S158422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894721PMC
April 2018
12 Reads

Unmet service needs evaluated by case managers among disabled patients on hemodialysis in Japan.

Int J Nephrol Renovasc Dis 2018 15;11:113-123. Epub 2018 Mar 15.

Sapporo Kita Clinic, Sapporo, Hokkai-do, Japan.

Background: This study aimed to investigate the levels of unmet needs for home and community-based services (HCBS) evaluated by case managers (CMs) among disabled patients on hemodialysis (DPHD) and to examine factors related to unmet needs. Unmet needs for HCBS were defined as situations in which patients do not use or underuse HCBS despite needing them. Candidates for the factors relating to unmet needs for HCBS included three dimensions: predisposing, enabling, and need factors. Read More

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http://dx.doi.org/10.2147/IJNRD.S152606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858655PMC
March 2018
4 Reads

BOLD magnetic resonance imaging in nephrology.

Int J Nephrol Renovasc Dis 2018 13;11:103-112. Epub 2018 Mar 13.

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.

Magnetic resonance (MR) imaging, a non-invasive modality that provides anatomic and physiologic information, is increasingly used for diagnosis of pathophysiologic conditions and for understanding renal physiology in humans. Although functional MR imaging methods were pioneered to investigate the brain, they also offer powerful techniques for investigation of other organ systems such as the kidneys. However, imaging the kidneys provides unique challenges due to potential complications from contrast agents. Read More

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http://dx.doi.org/10.2147/IJNRD.S112299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856054PMC
March 2018
3 Reads

Anxiety and depression in patients with end-stage renal disease: impact and management challenges - a narrative review.

Int J Nephrol Renovasc Dis 2018 12;11:93-102. Epub 2018 Mar 12.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Psychiatric disorders commonly co-exist with the diagnosis of chronic kidney disease (CKD). Research on depression and CKD has increased to a great extent. Multiple studies have demonstrated that depression is more prevalent in CKD and that end-stage renal disease is a robust risk factor for adverse outcomes such as hospitalization and mortality, yet these are often underdiagnosed or untreated. Read More

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http://dx.doi.org/10.2147/IJNRD.S126615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856029PMC
March 2018
5 Reads

The importance of the thick ascending limb of Henle's loop in renal physiology and pathophysiology.

Int J Nephrol Renovasc Dis 2018 15;11:81-92. Epub 2018 Feb 15.

Division of Nephrology, Department of Cardio-Thoracic and Respiratory Sciences, Università della Campania "Luigi Vanvitelli", Naples, Italy.

The thick ascending limb (TAL) of Henle's loop is a crucial segment for many tasks of the nephron. Indeed, the TAL is not only a mainstay for reabsorption of sodium (Na), potassium (K), and divalent cations such as calcium (Ca) and magnesium (Mg) from the luminal fluid, but also has an important role in urine concentration, overall acid-base homeostasis, and ammonia cycle. Transcellular Na transport along the TAL is a prerequisite for Na, K, Ca, Mg homeostasis, and water reabsorption, the latter through its contribution in the generation of the cortico-medullar osmotic gradient. Read More

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http://dx.doi.org/10.2147/IJNRD.S154000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818843PMC
February 2018
5 Reads

Managing hyperparathyroidism in hemodialysis: role of etelcalcetide.

Int J Nephrol Renovasc Dis 2018 5;11:69-80. Epub 2018 Feb 5.

Division of Nephrology, Hennepin County Medical Center, University of Minnesota, Minneapolis, MN.

Secondary hyperparathyroidism (SHPT) is common in patients receiving maintenance hemodialysis and is associated with adverse outcomes. Currently, SHPT is managed by reducing circulating levels of phosphate with oral binders and parathyroid hormone (PTH) with vitamin D analogs and/or the calcimimetic cinacalcet. Etelcalcetide, a novel calcimimetic administered intravenously (IV) at the end of a hemodialysis treatment session, effectively reduces PTH in clinical trials when given thrice weekly. Read More

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http://dx.doi.org/10.2147/IJNRD.S128252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804266PMC
February 2018
5 Reads

Is the light at the end of the tunnel nigh? A review of ADPKD focusing on the burden of disease and tolvaptan as a new treatment.

Int J Nephrol Renovasc Dis 2018 1;11:53-67. Epub 2018 Feb 1.

Pediatric Nephrology Center of Excellence, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Autosomal dominant polycystic kidney disease (ADPKD) causes pathological cystic changes to the kidney and is characterized by numerous renal and systemic manifestations. ADPKD is the fourth most common renal disease requiring renal replacement therapy. In this report, we present a detailed review of ADPKD, with a particular focus on its major economic, psychological, and social burden in affected patients. Read More

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http://dx.doi.org/10.2147/IJNRD.S136359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798550PMC
February 2018
7 Reads

Tolvaptan in the treatment of autosomal dominant polycystic kidney disease: patient selection and special considerations.

Int J Nephrol Renovasc Dis 2018 31;11:41-51. Epub 2018 Jan 31.

Faculty of Medicine, Université Paris-Descartes, Assistance Publique-Hôpitaux de Paris, Service de Néphrologie, Hôpital Necker-Enfants Malades, Paris, France.

Standard of care therapies for autosomal dominant polycystic kidney disease (ADPKD) may limit morbidity and mortality due to disease-related complications, but they do not delay disease progression. Tolvaptan, a selective vasopressin V2 receptor antagonist, delays the increase in kidney volume (a surrogate marker for disease progression), slows the decline in renal function, and reduces pain in ADPKD patients with relatively preserved renal function. The most common adverse events of tolvaptan are linked to its aquaretic effect, and rare cases of idiosyncratic hepatitis were observed. Read More

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http://dx.doi.org/10.2147/IJNRD.S125942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797468PMC
January 2018
4 Reads

The clinicopathological features of patients with membranous nephropathy.

Int J Nephrol Renovasc Dis 2018 18;11:33-40. Epub 2018 Jan 18.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing Key Laboratory of Kidney Disease, Beijing, China.

Background: Membranous nephropathy (MN) represents a distinct glomerular disease which has been considered as a major cause of nephrotic syndrome (NS) in adults. Evidences show that the clinicopathological features of MN are various among MN cases. This study aimed to summarize and analyze the clinicopathological features of patients with MN. Read More

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http://dx.doi.org/10.2147/IJNRD.S149029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779279PMC
January 2018
4 Reads

Pulse versus daily oral Alfacalcidol treatment of secondary hyperparathyroidism in hemodialysis patients: a randomized controlled trial.

Int J Nephrol Renovasc Dis 2018 15;11:25-32. Epub 2018 Jan 15.

Public Health Department, College of Health Sciences, Qatar University, Doha, Qatar.

Background: Secondary hyperparathyroidism is a common complication of chronic kidney disease and is managed using vitamin D replacement therapy. Very few studies have examined the effectiveness of pulse alfacalcidol therapy in comparison to daily oral alfacalcidol therapy in suppressing serum parathyroid hormone (PTH) levels in hemodialysis patients. The aim of this randomized controlled trial was to replicate the findings of prior studies comparing effectiveness of pulse oral alfacalcidol therapy versus daily oral alfacalcidol therapy in suppressing PTH after 13 weeks of therapy using a Palestinian sample of hemodialysis patients, and to identify demographic and biomedical characteristics of patients that are independently associated with PTH levels. Read More

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http://dx.doi.org/10.2147/IJNRD.S149877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774473PMC
January 2018
9 Reads

Post-marketing surveillance study of the safety and efficacy of nalfurafine hydrochloride (Remitch capsules 2.5 μg) in 3,762 hemodialysis patients with intractable pruritus.

Int J Nephrol Renovasc Dis 2018 15;11:9-24. Epub 2018 Jan 15.

Pharmaceutical and Medical Device Vigilance Department, Toray Industries, Inc., Tokyo, Japan.

Background: Intractable pruritus in hemodialysis patients can significantly decrease their quality of life and is also associated with poor vital prognosis. Although combined multiple causes of intractable pruritus in these patients have been identified, no existing treatments are proven to be sufficiently effective. We conducted a post-marketing surveillance to follow-up and assess the safety and efficacy of nalfurafine, a selective κ-opioid receptor agonist, for the treatment of intractable pruritus in patients undergoing hemodialysis. Read More

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http://dx.doi.org/10.2147/IJNRD.S145720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774492PMC
January 2018
8 Reads

Calcium channel blockade and survival in recipients of successful renal transplant: an analysis of the FAVORIT trial results.

Int J Nephrol Renovasc Dis 2018 22;11:1-7. Epub 2017 Dec 22.

Kidney and Hypertension Section, Joslin Diabetes Center.

Introduction: Single-center and observational studies have suggested that calcium channel blocking agents may decrease the expression of sepsis in individual populations. In the renal transplant population, a role for calcium channel blockers in allograft protection and in prevention of sepsis has been postulated. We hypothesized that any important survival benefit or risk related to chronic use of calcium channel blocking agents should be discernable through an analysis of a large database of stable recipients of renal allografts who had enrolled in a large international trial. Read More

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http://dx.doi.org/10.2147/IJNRD.S148517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743121PMC
December 2017
5 Reads

Nutcracker syndrome associated with celiacomesentric trunk anomaly: case report.

Int J Nephrol Renovasc Dis 2017 13;10:285-288. Epub 2017 Dec 13.

Department of Surgery.

Introduction: Nutcracker syndrome is a rare disease entity that is caused by entrapment of the left renal vein between the aorta and superior mesenteric artery, usually due to abnormal branching of the superior mesenteric artery from the aorta causing renal venous hypertension. The symptoms vary from asymptomatic hematuria to severe pelvic congestion. Celiacomes-enteric trunk anomaly is a rare variation of splanchnic artery anomaly that occurs when the celiac trunk and superior mesenteric arteries have a common origin from the aorta. Read More

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https://www.dovepress.com/nutcracker-syndrome-associated-wit
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http://dx.doi.org/10.2147/IJNRD.S146814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732549PMC
December 2017
8 Reads

Urinary protein profiles in ketorolac-associated acute kidney injury in patients undergoing orthopedic day surgery.

Int J Nephrol Renovasc Dis 2017 18;10:269-274. Epub 2017 Sep 18.

Department of General and Specialist Medicine, Nephrology, Dialysis and Transplantation Unit, City of Health and Science, CTO Hospital, Turin.

Background: Parenteral administration of ketorolac is very effective in controlling postoperative pain for orthopedic surgery. Ketorolac can induce clinically relevant renal alterations in elderly patients, whereas its short course is considered safe for young adults with normal preoperative renal function. In this study, of a cohort of young adults undergoing elective orthopedic day surgery, we sought cases complicated by readmission due to acute kidney injury (AKI). Read More

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http://dx.doi.org/10.2147/IJNRD.S137102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609791PMC
September 2017
6 Reads

Efficacy and safety of subcutaneous administration of lyophilized powder of alfa-erythropoietin to maintain hemoglobin concentrations among hemodialysis patients.

Int J Nephrol Renovasc Dis 2017 20;10:275-283. Epub 2017 Sep 20.

Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.

Background: Anemia associated with chronic kidney disease (CKD) often requires treatment with recombinant human erythropoietin (EPO). This study investigated the therapeutic equivalence between lyophilized powder and standard liquid EPO alfa by subcutaneous (SC) administration in hemoglobin maintenance among patients on hemodialysis.

Methods: This was a single-blinded, randomized, controlled, single-center, parallel-group study regarding the treatment of anemia among CKD patients on hemodialysis and being treated with stable doses of EPO alfa at least for 12 weeks. Read More

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http://dx.doi.org/10.2147/IJNRD.S143731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614773PMC
September 2017
5 Reads

Role of serum cystatin-C and beta-2 microglobulin as early markers of renal dysfunction in children with beta thalassemia major.

Int J Nephrol Renovasc Dis 2017 11;10:261-268. Epub 2017 Sep 11.

Clinical Pathology Department, General Organization of Teaching Hospitals and Institutes, Egypt.

Background: Although advancements have been made in the management of thalassemic patients, many unrecognized complications have emerged, such as renal abnormalities.

Aim: To measure serum levels of cystatin-C and β-2 microglobulin in children with beta-thalassemia major (β-TM) and investigate their significance as early markers of glomerular and tubular dysfunctions.

Subjects And Methods: The study was performed on 70 children with (β-TM) and 20 apparently healthy children matched for age and sex as a control group. Read More

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http://dx.doi.org/10.2147/IJNRD.S142824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602444PMC
September 2017
5 Reads

Transforming growth factor-β1/Smad3-independent epithelial-mesenchymal transition in type I collagen glomerulopathy.

Int J Nephrol Renovasc Dis 2017 31;10:251-259. Epub 2017 Aug 31.

Department of Child Health, University of Missouri, Columbia, MO, USA.

The glomerulofibrotic -deficient mouse model demonstrates glomerular homotrimeric type I collagen deposition in mesangial and subendothelial spaces. In this report, we investigate the role of transforming growth factor β1 (TGF-β1) in myofibroblast activation and epithelial-mesenchymal transition (EMT) in this glomerulopathy. Immunohistochemical analyses of glomerular α-sma, desmin, vimentin, and proliferating cell nuclear antigen demonstrated parietal epithelial cell proliferation and EMT in late stages of the glomerulopathy in the -deficient mice. Read More

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https://www.dovepress.com/transforming-growth-factor-beta1sm
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http://dx.doi.org/10.2147/IJNRD.S141393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587152PMC
August 2017
7 Reads

Renal sympathetic denervation increases renal blood volume per cardiac cycle: a serial magnetic resonance imaging study in resistant hypertension.

Int J Nephrol Renovasc Dis 2017 31;10:243-249. Epub 2017 Aug 31.

Cardiovascular Research Centre, Royal Adelaide Hospital.

Aim: Preclinical studies have demonstrated improvements in renal blood flow after renal sympathetic denervation (RSDN); however, such effects are yet to be confirmed in patients with resistant hypertension. Herein, we assessed the effects of RSDN on renal artery blood flow and diameter at multiple time points post-RSDN.

Methods And Results: Patients (n=11) with systolic blood pressures ≥160 mmHg despite taking three or more antihypertensive medications at maximum tolerated dose were recruited into this single-center, prospective, non-blinded study. Read More

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http://dx.doi.org/10.2147/IJNRD.S131220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587163PMC
August 2017
19 Reads

Does diabetes impact therapeutic immunomodulation therapy decisions for kidney transplant recipients? Data from the Folic Acid for Vascular Outcome Reduction in Transplant (FAVORIT) trial.

Int J Nephrol Renovasc Dis 2017 18;10:233-242. Epub 2017 Aug 18.

Medicine and Surgery, Beth Israel Deaconess Medical Center, Boston MA.

Although survival has improved for kidney transplant recipients over the past several decades, long-term survival in diabetic cohorts still is significantly less than that of non-diabetic cohorts. We hypothesized that among stable kidney transplant recipients, there might be differences between subgroups with and without diabetes with respect to prevalence of prior cardiovascular events and post-transplant antihypertensive and immunosuppressive therapy. We performed a post hoc analysis of participants in the Folic Acid for Vascular Outcome Reduction in Transplant (FAVORIT) trial, a multicenter international trial of 4110 prevalent kidney transplant recipients enrolled from 2002 to 2007 evaluating the effect of homocysteine-lowering vitamin therapy on cardiovascular outcomes. Read More

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http://dx.doi.org/10.2147/IJNRD.S139901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571849PMC
August 2017
7 Reads

The role of novel biomarkers in predicting diabetic nephropathy: a review.

Int J Nephrol Renovasc Dis 2017 17;10:221-231. Epub 2017 Aug 17.

Pediatric Nephrology Firm, Department of Pediatrics, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.

Diabetic nephropathy (DN) is one of the microvascular complications of the kidney arising commonly from type 1 diabetes mellitus (T1DM), and occasionally from type 2 diabetes mellitus (T2DM). Microalbuminuria serves as an early indicator of DN risk and a predictor of its progression as well as cardiovascular disease risk in both T1DM and T2DM. Although microalbuminuria remains the gold standard for early detection of DN, it is not a sufficiently accurate predictor of DN risk due to some limitations. Read More

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http://dx.doi.org/10.2147/IJNRD.S143186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566367PMC
August 2017
10 Reads

Stent tunnel technique to save thrombosed native hemodialysis fistula with extensive venous aneurysm.

Int J Nephrol Renovasc Dis 2017 27;10:215-219. Epub 2017 Jul 27.

Department of Angiography and Endovascular Therapy.

Introduction And Purpose: The increasing number of patients undergoing hemodialysis and the limited number of access sites have resulted in an increasing number of techniques to maintain vascular access for hemodialysis. Thrombosed arteriovenous (AV) fistulas with large venous aneurysms have poor treatment results, with both endovascular and surgical techniques, leading to a high rate of definitive AV access loss. The purpose of this study was to review the feasibility and initial results of this novel endovascular treatment of thrombosed AV fistulas with large venous aneurysms. Read More

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http://dx.doi.org/10.2147/IJNRD.S137905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538692PMC
July 2017
10 Reads

Hypertension in pediatric patients with chronic kidney disease: management challenges.

Int J Nephrol Renovasc Dis 2017 26;10:205-213. Epub 2017 Jul 26.

Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada.

In contrast to adults where hypertension is a leading cause of chronic kidney disease, in pediatrics, hypertension is predominantly a sequela, however, an important one that, like in adults, is likely associated with a more rapid decline in kidney function or progression of chronic kidney disease to end stage. There is a significant issue with unrecognized, or masked, hypertension in childhood chronic kidney disease. Recent evidence and, therefore, guidelines now suggest targeting a blood pressure of <50th percentile for age, sex, and height in children with proteinuria and chronic kidney disease. Read More

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http://dx.doi.org/10.2147/IJNRD.S100891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538700PMC
July 2017
9 Reads

Assessment of quality of life in patients undergoing hemodialysis using WHOQOL-BREF questionnaire: a multicenter study.

Int J Nephrol Renovasc Dis 2017 19;10:195-203. Epub 2017 Jul 19.

Department of Internal Medicine, Tribhuvan University, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.

Background: Assessment of quality of life (QOL) of patients with end-stage renal disease has become increasingly important, both in order to evaluate the influence of the disease on patients and the type of renal replacement therapy they require. Therefore, in this study, we aimed to assess QOL in patients undergoing hemodialysis and evaluated the effects of various sociodemographic factors affecting QOL of such patients in Nepal.

Methods: A cross-sectional study was conducted among 150 patients with chronic kidney disease undergoing hemodialysis at two major centers in Nepal. Read More

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http://dx.doi.org/10.2147/IJNRD.S136522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529382PMC
July 2017
22 Reads

The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome.

Int J Nephrol Renovasc Dis 2017 22;10:167-174. Epub 2017 Jun 22.

Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Semaphorin3A is a secreted protein known to be involved in organogenesis, immune responses and cancer. In the kidney, semaphorin3A is expressed in the glomerular podocytes, distal tubules and collecting tubules, and believed to play a role in the regulation of the kidney development and function. We examined the serum and urinary semaphorin3A levels in 72 patients with renal disease and 5 healthy volunteers. Read More

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http://dx.doi.org/10.2147/IJNRD.S132980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489052PMC
June 2017
10 Reads

Is it possible to preserve the blood supply of erectile organs by anastomosis using the hypogastric artery in kidney transplantation?

Int J Nephrol Renovasc Dis 2017 10;10:191-193. Epub 2017 Jul 10.

Department of Urology and Kidney Transplantation, Emam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Three modalities for treating chronic kidney failure are peritoneal dialysis, hemodialysis, and kidney transplantation. Among them kidney transplantation is cost-efficient and leads to a somewhat normal quality of life. In this approach, most often the external iliac artery is selected for anastomosis, but this could be disastrous if anastomosis leads to a complication. Read More

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http://dx.doi.org/10.2147/IJNRD.S127172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513852PMC
July 2017
5 Reads

Determinants and prevalence of depression in patients with chronic renal disease, and their caregivers.

Int J Nephrol Renovasc Dis 2017 3;10:183-189. Epub 2017 Jul 3.

College of Nursing, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

Introduction: This study explored the prevalence of depression among the patients with chronic kidney disease and their caregivers and its association to their demographic profile.

Methods: A descriptive, correlational, cross-sectional study that used the Hamilton rating scale tool to assess the prevalence of depression among 226 patients undergoing hemodialysis and 105 of their caregivers in a hospital in Saudi Arabia.

Results: Patients with chronic renal disease and their caregivers experience depression at varying levels. Read More

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http://dx.doi.org/10.2147/IJNRD.S139652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503667PMC
July 2017
4 Reads