4,604 results match your criteria International Journal of Nanomedicine[Journal]


Multiple cargo deliveries of growth factors and antimicrobial peptide using biodegradable nanopolymer as a potential wound healing system.

Int J Nanomedicine 2019 29;14:2253-2263. Epub 2019 Mar 29.

Chemical Biology, Nano Drug Delivery Systems (NDDS), Bio-Innovation Center (BIC), Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala 695014, India,

Background: Treatment of wounds with the help of nanoparticles (NPs) is more effective and superior in comparison to traditional wound healing methods as it protects and sustains active drug release at the wound site thus enhancing the safety of the drug and reducing the possibility of side effects. The advantages of this method are the possibility of allowing a reduction in administered dose, limiting toxicity levels to the minimum, and increasing safety of topical delivery of the drug.

Materials And Methods: We report the synthesis of a novel poly (lactic-co-glycolic acid) (PLGA) NP-based multicargo delivery system for growth factors and antimicrobial peptide. Read More

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http://dx.doi.org/10.2147/IJN.S190321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445221PMC
March 2019
1 Read

Biomimetic hydroxyapatite nanocrystals are an active carrier for bacteriophages.

Int J Nanomedicine 2019 28;14:2219-2232. Epub 2019 Mar 28.

Department of Agriculture, University of Naples "Federico II", Portici, Naples, Italy,

Purpose: The use of bacteriophages represents a valid alternative to conventional antimicrobial treatments, overcoming the widespread bacterial antibiotic resistance phenomenon. In this work, we evaluated whether biomimetic hydroxyapatite (HA) nanocrystals are able to enhance some properties of bacteriophages. The final goal of this study was to demonstrate that biomimetic HA nanocrystals can be used for bacteriophage delivery in the context of bacterial infections, and contribute - at the same time - to enhance some of the biological properties of the same bacteriophages such as stability, preservation, antimicrobial activity, and so on. Read More

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https://www.dovepress.com/biomimetic-hydroxyapatite-nanocrys
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http://dx.doi.org/10.2147/IJN.S190188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445186PMC
March 2019
2 Reads

Superparamagnetic iron oxide nanoparticles combined with NGF and quercetin promote neuronal branching morphogenesis of PC12 cells.

Int J Nanomedicine 2019 27;14:2157-2169. Epub 2019 Mar 27.

Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran.

Background: The investigation of agents promoting recovery of nerve regeneration following neurodegenerative diseases has been the most important issue in neuroscience. Nerve growth factor (NGF) and quercetin as potential flavonoids could possibly have therapeutic applications in the field of degenerative diseases such as Parkinson and Alzheimer.

Materials And Methods: The MTT assay was done at 24, 48, and 72 hours to examine the cytotoxicity of superparamagnetic iron oxide nanoparticles (SPIONs) and quercetin. Read More

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http://dx.doi.org/10.2147/IJN.S191878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445231PMC
March 2019
1 Read

Psoralen-loaded lipid-polymer hybrid nanoparticles enhance doxorubicin efficacy in multidrug-resistant HepG2 cells.

Int J Nanomedicine 2019 27;14:2207-2218. Epub 2019 Mar 27.

College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China,

Background: Psoralen (PSO), a major active component of Psoralea corylifolia, has been shown to overcome multidrug resistance in cancer. A drug carrier comprising a lipid-monolayer shell and a biodegradable polymer core for sustained delivery and improved efficacy of drug have exhibited great potential in efficient treatment of cancers.

Methods: The PSO-loaded lipid polymer hybrid nanoparticles were prepared and characterized. Read More

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http://dx.doi.org/10.2147/IJN.S189924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443224PMC

In vitro comparison of liposomal drug delivery systems targeting the oxytocin receptor: a potential novel treatment for obstetric complications.

Int J Nanomedicine 2019 27;14:2191-2206. Epub 2019 Mar 27.

Centre for Organic Electronics, University of Newcastle, Callaghan, NSW, Australia.

Introduction: Targeted intervention to the uterus has great potential for the treatment of obstetric complications (eg, preterm birth, dysfunctional labor, and postpartum hemorrhage) by improving the effectiveness and safety of therapeutic compounds. In particular, targeting the oxytocin receptor (OTR) is a novel approach for drug delivery to the uterus. The aim of this study was to report the complete data set for the pharmaceutical synthesis and in vitro characterization of PEGylated liposomes conjugated with anti-OTR monoclonal antibodies (OTR-Lipo) or atosiban (ATO-Lipo, OTR antagonist). Read More

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http://dx.doi.org/10.2147/IJN.S198116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443222PMC
March 2019
1 Read

Starch-mediated synthesis of mono- and bimetallic silver/gold nanoparticles as antimicrobial and anticancer agents.

Int J Nanomedicine 2019 27;14:2171-2190. Epub 2019 Mar 27.

School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, NL 64849, Mexico,

Background And Aim: Bimetallic silver/gold nanosystems are expected to significantly improve therapeutic efficacy compared to their monometallic counterparts by maintaining the general biocompatibility of gold nanoparticles (AuNPs) while, at the same time, decreasing the relatively high toxicity of silver nanoparticles (AgNPs) toward healthy human cells. Thus, the aim of this research was to establish a highly reproducible one-pot green synthesis of colloidal AuNPs and bimetallic Ag/Au alloy nanoparticles (NPs; Ag/AuNPs) using starch as reducing and capping agent.

Methods: The optical properties, high reproducibility, stability and particle size distribution of the colloidal NPs were analyzed by ultraviolet (UV)-visible spectroscopy, dynamic light scattering (DLS) and -potential. Read More

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http://dx.doi.org/10.2147/IJN.S192757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443225PMC

DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats.

Int J Nanomedicine 2019 27;14:2145-2156. Epub 2019 Mar 27.

Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran,

Aims: Despite daily increase in diabetic patients in the world, currently approved medications for this disease, at best, only reduce its progression speed. Using novel technologies is a solution for synthetizing more efficient medicines. In the present study, we evaluated anti-diabetic effects of DIBc, a nano metal-organic framework, which is synthetized based on nanochelating technology. Read More

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http://dx.doi.org/10.2147/IJN.S196050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443220PMC

Electrospun polycaprolactone/collagen nanofibers cross-linked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/hydroxysuccinimide and genipin facilitate endothelial cell regeneration and may be a promising candidate for vascular scaffolds.

Int J Nanomedicine 2019 26;14:2127-2144. Epub 2019 Mar 26.

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Purpose: A promising vascular scaffold must possess satisfying mechanical properties, great hemocompatibility, and favorable tissue regeneration. Combining natural with synthetic materials is a popular method of creating/enhancing such scaffolds. However, the effect of additional modification on the materials requires further exploration. Read More

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https://www.dovepress.com/electrospun-polycaprolactonecollag
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http://dx.doi.org/10.2147/IJN.S192699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440451PMC
March 2019
1 Read

One-step mechanochemical preparation and prominent antitumor activity of SN-38 self-micelle solid dispersion.

Int J Nanomedicine 2019 26;14:2115-2126. Epub 2019 Mar 26.

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310006, China,

Purpose: The purpose of this study was to overcome the clinical defects of 7-ethyl-10-hydroxycamptothecin (SN-38) and explore its characteristics and antitumor effects.

Materials And Methods: An amorphous solid dispersion of SN-38 with disodium glycyrrhizin (NaGA) was prepared by mechanical ball milling (NaGA/SN-38-BM). Moreover, an untreated mixture of NaGA and SN-38 (NaGA/SN-38-UM), a pure drug SN-38, was prepared for comparison with NaGA/SN-38-BM. Read More

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http://dx.doi.org/10.2147/IJN.S193783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440449PMC

Structural switching electrochemical DNA aptasensor for the rapid diagnosis of tuberculous meningitis.

Int J Nanomedicine 2019 26;14:2103-2113. Epub 2019 Mar 26.

AptaBharat Innovation Pvt. Ltd., Faridabad, India,

Background: Tuberculous meningitis (TBM) is the most devastating manifestation of extra-pulmonary tuberculosis. About 33% of TBM patients die due to very late diagnosis of the disease. Conventional diagnostic methods based on signs and symptoms, cerebrospinal fluid (CSF) smear microscopy or liquid culture suffer from either poor sensitivity or long turnaround time (up to 8 weeks). Read More

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http://dx.doi.org/10.2147/IJN.S189127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440448PMC
March 2019
2 Reads

Di--lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity.

Int J Nanomedicine 2019 26;14:2091-2102. Epub 2019 Mar 26.

Micro & Nanomédecines Translationelles - MINT, UNIV Angers, INSERM 1066, CNRS 6021, University of Angers, MINT IBS-CHU, Larrey, 49933 Angers, France,

Background: Acute myeloid leukemia mainly affects adult patients. Complete remission for patients younger than 60 years, who are candidates for standard induction therapy, is achieved in 60%-80% of cases. However, the prognosis is still poor for older patients, who are unfit for intensive chemotherapy, and only a few therapies are available. Read More

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https://www.dovepress.com/di-o-lauroyl-decitabine-lipid-nano
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http://dx.doi.org/10.2147/IJN.S190482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440450PMC
March 2019
2 Reads

Liposomes targeted to MHC-restricted antigen improve drug delivery and antimelanoma response.

Int J Nanomedicine 2019 26;14:2069-2089. Epub 2019 Mar 26.

Laboratory of Experimental Surgical Oncology, Section Surgical Oncology, Department of Surgery, Erasmus MC, Rotterdam, The Netherlands,

Purpose: Melanoma is the most aggressive form of skin cancer. Chemotherapy at a late stage fails due to low accumulation in tumors, indicating the need for targeted therapy.

Materials And Methods: To increase drug uptake by tumor cells, we have targeted doxorubicin-containing liposomes using a T-cell receptor (TCR)-like antibody (scFv G8 and Hyb3) directed against melanoma antigen A1 (MAGE-A1) presented by human leukocyte antigen A1 (M1/A1). Read More

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https://www.dovepress.com/liposomes-targeted-to-mhc-restrict
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http://dx.doi.org/10.2147/IJN.S190736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440454PMC
March 2019
2 Reads

Plasma protein adsorption on FeO-PEG nanoparticles activates the complement system and induces an inflammatory response.

Int J Nanomedicine 2019 25;14:2055-2067. Epub 2019 Mar 25.

Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), Ciudad de México, México,

Background: Understanding of iron oxide nanoparticles (IONP) interaction with the body milieu is crucial to guarantee their efficiency and biocompatibility in nanomedicine. Polymer coating to IONP, with polyethyleneglycol (PEG) and polyvinylpyrrolidone (PVP), is an accepted strategy to prevent toxicity and excessive protein binding.

Aim: The aim of this study was to investigate the feature of IONP adsorption of complement proteins, their activation and consequent inflammatory response as a strategy to further elucidate their biocompatibility. Read More

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http://dx.doi.org/10.2147/IJN.S192214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438142PMC
March 2019
2 Reads

Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment.

Int J Nanomedicine 2019 22;14:2029-2053. Epub 2019 Mar 22.

Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,

Cancer is a major public health problem, and is now the world's leading cause of death. Traditional Chinese medicine (TCM)-combination therapy is a new treatment approach and a vital therapeutic strategy for cancer, as it exhibits promising antitumor potential. Nano-targeted drug-delivery systems have remarkable advantages and allow the development of TCM-combination therapies by systematically controlling drug release and delivering drugs to solid tumors. Read More

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http://dx.doi.org/10.2147/IJN.S197889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435121PMC

Osteochondral repair using scaffolds with gradient pore sizes constructed with silk fibroin, chitosan, and nano-hydroxyapatite.

Int J Nanomedicine 2019 22;14:2011-2027. Epub 2019 Mar 22.

Department of Orthopedics, Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, People's Republic of China,

Background: One of the main problems associated with the development of osteochondral reparative materials is that the accurate imitation of the structure of the natural osteochondral tissue and fabrication of a suitable scaffold material for osteochondral repair are difficult. The long-term outcomes of single- or bilayered scaffolds are often unsatisfactory because of the absence of a progressive osteochondral structure. Therefore, only scaffolds with gradient pore sizes are suitable for osteochondral repair to achieve better proliferation and differentiation of the stem cells into osteochondral tissues to complete the repair of defects. Read More

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http://dx.doi.org/10.2147/IJN.S191627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435123PMC
March 2019
1 Read

pH-sensitive doxorubicin-loaded polymeric nanocomplex based on β-cyclodextrin for liver cancer-targeted therapy.

Int J Nanomedicine 2019 21;14:1997-2010. Epub 2019 Mar 21.

School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China,

Background: Doxorubicin (DOX) is one of the most effective treatments for hepatocellular carcinoma (HCC), but is restricted by its poor pharmacokinetics. Herein, we exploited efficient targeted drug delivery systems and they have been found to be a worthy strategy for liver cancer therapy.

Materials And Methods: We investigated polymeric nanoparticles which were synthesized based on host-guest interaction between β-cyclodextrin and benzimidazole. Read More

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http://dx.doi.org/10.2147/IJN.S193170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433111PMC

Intraperitoneal delivery of acetate-encapsulated liposomal nanoparticles for neuroprotection of the penumbra in a rat model of ischemic stroke.

Int J Nanomedicine 2019 18;14:1979-1991. Epub 2019 Mar 18.

University of Westminster, Research Centre for Optimal Health, London, UK.

Background: Ischemic stroke is a devastating condition, with metabolic derangement and persistent inflammation enhancing the initial insult of ischaemia. Recombinant tissue plasminogen remains the only effective treatment but limited as therapy must commence soon after the onset of symptoms.

Purpose: We investigated whether acetate, which modulates many pathways including inflammation, may attenuate brain injury in stroke. Read More

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http://dx.doi.org/10.2147/IJN.S193965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430000PMC
March 2019
3 Reads

Biosynthesis, characterization, and anticancer effect of plant-mediated silver nanoparticles using .

Int J Nanomedicine 2019 15;14:1969-1978. Epub 2019 Mar 15.

Department of Integrated Traditional Chinese and Western Medicine, The Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan 450008, China,

Background: Tremendous growth in nanotechnology has opened up new frontiers in fundamental and applied aspects, including the synthesis of nanoscale matter and understanding/utilizing its exotic physicochemical and optoelectronic properties. Green-synthesis methods employing either biological microorganisms or plant extracts have emerged as a simple and alternative to chemical synthesis.

Methods: In our present study, we aimed to synthesize silver nanoparticles (AgNPs) in combination with an aqueous extract of (CC) using a suitable ecofriendly green-synthesis way. Read More

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http://dx.doi.org/10.2147/IJN.S188235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421896PMC

Use of transethosomes for enhancing the transdermal delivery of olmesartan medoxomil: in vitro, ex vivo, and in vivo evaluation.

Int J Nanomedicine 2019 15;14:1953-1968. Epub 2019 Mar 15.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt,

Introduction And Aim: Olmesartan medoxomil (OLM) is an antihypertensive drug with low oral bioavailability due to extensive first-pass metabolism. This study aimed to prepare transetho somes (TEs) for enhancing the transdermal delivery of OLM to avoid its oral problems.

Methods: TE formulae were prepared utilizing 51. Read More

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http://dx.doi.org/10.2147/IJN.S196771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421897PMC

Lipid-polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives.

Int J Nanomedicine 2019 19;14:1937-1952. Epub 2019 Mar 19.

Drug Discovery and Nanomedicine Research Program,

Lipid-polymer hybrid nanoparticles (LPHNPs) are next-generation core-shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous. Recently, a fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids. Read More

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http://dx.doi.org/10.2147/IJN.S198353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430183PMC
March 2019
1 Read

NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study.

Int J Nanomedicine 2019 15;14:1919-1936. Epub 2019 Mar 15.

Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.

Purpose: This study evaluated the effects of titanium dioxide nanoparticles (TiO NPs) on liver and intestine of normal rats.

Methods: Male rats were divided into four groups as follows: 1) control rats, 2) control rats that orally received 10 mg/kg TiO NPs, 3) control rats that orally received 50 mg/kg TiO NPs, and 4) control rats that orally received 100 mg/kg TiO NPs. After 30 days, the NLRP3 inflammasome pathway (NLRP3, caspase-1, and IL-1β), antioxidant pathway (superoxide dismutase [SOD], glutathione peroxidase [GPx], and catalase [CAT]), inflammatory pathway (inducible nitric oxide synthase [iNOS] and tumor necrosis factor-α [TNF-α]), and the apoptosis pathway (p53, Bax, Bcl-2, and caspase-3) were determined in the intestine and liver of the rats. Read More

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http://dx.doi.org/10.2147/IJN.S192382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421874PMC

Culture of dental pulp stem cells on nanoporous alumina substrates modified by carbon nanotubes.

Int J Nanomedicine 2019 14;14:1907-1918. Epub 2019 Mar 14.

Marquette University School of Dentistry, Milwaukee, WI, USA.

Purpose: Alumina substrates are one of the commonly used scaffolds applied in cell culture, but in order to prevent formation of biofilm on the alumina substrate, these substrates are modified with carbon nanotube.

Methods: The alumina substrate was made by a two-step anodization method and was then modified with carbon nanotubes by simple chemical reaction. The substrates were characterized with FTIR, SEM, EDX, 3D laser scanning digital microscope, contact angle (CA) and surface free energy (SFE). Read More

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http://dx.doi.org/10.2147/IJN.S189730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421869PMC

Engineering of solidified glyburide nanocrystals for tablet formulation via loading of carriers: downstream processing, characterization, and bioavailability.

Int J Nanomedicine 2019 13;14:1893-1906. Epub 2019 Mar 13.

Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia,

Introduction: Presenting poorly water-soluble drugs as nanoparticles has shown to be an effective technique in enhancing drug dissolution rate, intrinsic solubility, and thus oral bioavailability. Nevertheless, working with nanoparticles introduces many challenges, one of which is their physical instability. Formulating nanoparticles into a solid dosage form may overcome such challenges and thus unlock the potential benefits of nanosizing. Read More

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http://dx.doi.org/10.2147/IJN.S194734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422418PMC
March 2019
2 Reads

A novel theranostic gold nanorods- and Adriamycin-loaded micelle for EpCAM targeting, laser ablation, and photoacoustic imaging of cancer stem cells in hepatocellular carcinoma.

Int J Nanomedicine 2019 13;14:1877-1892. Epub 2019 Mar 13.

Department of Industrial Chemistry "Toso Montanari", Bologna, Italy,

Introduction And Purpose: Cancer stem cells (CSCs) present a higher capacity to evade being killed by cancer agents and developing chemoresistance, thus leading to failure of conventional anticancer therapeutics. Nanomaterials specifically designed for targeting and treating not only tumor cells, but also CSCs, may encompass therapeutic and diagnostic tools, thus successfully eradicating the tumor.

Materials And Methods: Polymeric micelles simultaneously loaded with gold nanorods (GNRs) and Adriamycin were prepared and used as a novel therapeutic and diagnostic weapon. Read More

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https://www.dovepress.com/a-novel-theranostic-gold-nanorods-
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http://dx.doi.org/10.2147/IJN.S197265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422422PMC
March 2019
6 Reads

Efficient recovery and enrichment of infectious rotavirus using separation with antibody-integrated graphite-encapsulated magnetic nanobeads produced by argon/ammonia gas plasma technology.

Int J Nanomedicine 2019 12;14:1865-1876. Epub 2019 Mar 12.

Research Institute of Electronics, Shizuoka University, Hamamatsu, Shizuoka 432-8561, Japan.

Background: Rotavirus is the representative cause of severe acute gastroenteritis in young children. A characteristic feature of rotavirus is low infectious dose and robustness of the virion, suggesting sanitation and hygiene will have little impact. Thus, development of a vaccine should be given priority. Read More

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http://dx.doi.org/10.2147/IJN.S191784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419588PMC
March 2019
1 Read

Nanosilver/poly (dl-lactic-co-glycolic acid) on titanium implant surfaces for the enhancement of antibacterial properties and osteoinductivity.

Int J Nanomedicine 2019 11;14:1849-1863. Epub 2019 Mar 11.

Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University, Jinan, People's Republic of China,

Background: Despite titanium (Ti) implants have been commonly used in the medical device field due to their superior biocompatibility, implant-associated bacterial infection remains a major clinical complication. Nanosilver, an effective antibacterial agent against a wide spectrum of bacterial strains, with a low-resistance potential, has attracted much interest too. Incorporation of nanosilver on Ti implants may be a promising approach to prevent biofilm formation. Read More

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http://dx.doi.org/10.2147/IJN.S190954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417851PMC
March 2019
1 Read

Promoting tendon to bone integration using graphene oxide-doped electrospun poly(lactic-co-glycolic acid) nanofibrous membrane.

Int J Nanomedicine 2019 11;14:1835-1847. Epub 2019 Mar 11.

Suzhou Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, Jiang Su, China,

Background: These normal entheses are not reestablished after repair despite significant advances in surgical techniques. There is a significant need to develop integrative biomaterials, facilitating functional tendon-to-bone integration.

Materials And Methods: We fabricated a highly interconnective graphene oxide-doped electrospun poly(lactide-co-glycolide acid) (GO-PLGA) nanofibrous membrane by electrospinning technique and evaluated them using in vitro cell assays. Read More

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http://dx.doi.org/10.2147/IJN.S183842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417852PMC

Development of anisamide-targeted PEGylated gold nanorods to deliver epirubicin for chemo-photothermal therapy in tumor-bearing mice.

Int J Nanomedicine 2019 8;14:1817-1833. Epub 2019 Mar 8.

School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China,

Background: Gold nanorods (AuNRs), due to the optical and electronic properties namely the surface plasma resonance, have been developed to achieve the light-mediated photothermal therapy (PTT) for cancer. However, PTT alone may suffer from inefficient tumor killing. Recently, the combination of PTT and chemotherapy has been utilized to achieve synergistic anticancer effects. Read More

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https://www.dovepress.com/development-of-anisamide-targeted-
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http://dx.doi.org/10.2147/IJN.S192520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413758PMC
March 2019
8 Reads

Synergistic antibacterial effect of ultrasound microbubbles combined with chitosan-modified polymyxin B-loaded liposomes on biofilm-producing .

Int J Nanomedicine 2019 8;14:1805-1815. Epub 2019 Mar 8.

Phase I Clinical Trial Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China,

Purpose: Resistant strains of (AB) that can form biofilms are resistant to polymyxin. Therefore, effective and safe polymyxin preparations against biofilm-producing AB are urgently needed. This study aims to prepare chitosan-modified polymyxin B-loaded liposomes (CLPs) and ultrasound microbubbles (USMBs) and then explore the synergistic antibacterial effects of USMBs combined with CLPs in vitro. Read More

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http://dx.doi.org/10.2147/IJN.S186571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413752PMC
March 2019
2 Reads

Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects.

Int J Nanomedicine 2019 8;14:1789-1804. Epub 2019 Mar 8.

School of Bioscience and Technology, Weifang Medical University, Weifang, Shandong, China,

Background: Recent efforts have been focused on combining two or more therapeutic approaches with different mechanisms to enhance antitumor therapy. Moreover, nanosize drug-delivery systems for codelivering two drugs with proapoptotic and antiangiogenic activities have exhibited great potential in efficient treatment of cancers.

Methods: Glycyrrhetinic acid (GA)-modified liposomes (GA LPs) for liver-targeted codelivery of curcumin (Cur) and combretastatin A4 phosphate (CA4P) were prepared and characterized. Read More

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http://dx.doi.org/10.2147/IJN.S188971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413741PMC
March 2019
1 Read

A novel strategy of transferring NIS protein to cells using extracellular vesicles leads to increase in iodine uptake and cytotoxicity.

Int J Nanomedicine 2019 7;14:1779-1787. Epub 2019 Mar 7.

Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea,

Background: This study was designed to explore a novel approach for transferring NIS protein to cells using extracellular vesicle (EV) and enhancing iodine avidity in hepatocellular carcinoma (HCC) cells.

Methods: We transfected the HCC cells (Huh7) with NIS gene, designated as Huh7/NIS, and isolated the EVs from them. Presence of NIS protein in EVs and EV-mediated transport of NIS protein to recipient Huh7 cells were tested using Western blotting. Read More

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http://dx.doi.org/10.2147/IJN.S189738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413815PMC
March 2019
2 Reads

Amelioration of diabetic nephropathy using pomegranate peel extract-stabilized gold nanoparticles: assessment of NF-κB and Nrf2 signaling system.

Int J Nanomedicine 2019 7;14:1753-1777. Epub 2019 Mar 7.

Cancer Biology and Inflammatory Disorder Division, Council of Scientific & Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India,

Background: Diabetic nephropathy (DN), an end-stage renal disorder, has posed a menace to humankind globally, because of its complex nature and poorly understandable intricate mechanism. In recent times, functional foods as potential health benefits have been gaining attention of consumers and researchers alike. Rich in antioxidants, the peel and seed of pomegranate have previously demonstrated protection against oxidative-stress-related diseases, including cardiovascular disorders, diabetes, and cancer. Read More

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http://dx.doi.org/10.2147/IJN.S176013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413818PMC
March 2019
1 Read

Photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection.

Int J Nanomedicine 2019 7;14:1737-1751. Epub 2019 Mar 7.

Korea Institute of Science and Technology, Seoul 02792, Korea.

Background: Zinc oxide (ZnO) nanoparticles and their networks have been developed for use in various applications such as gas sensors and semiconductors.

Aim: In this study, their antibacterial activity against under dual ultraviolet (UV) irradiation for disinfection was investigated.

Materials And Methods: ZnO nanoparticles were synthesized and immobilized onto silicon (Si) wafers by self-assembly. Read More

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http://dx.doi.org/10.2147/IJN.S192277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413819PMC

Biological response of chemically treated surface of the ultrafine-grained Ti-6Al-7Nb alloy for biomedical applications.

Int J Nanomedicine 2019 6;14:1725-1736. Epub 2019 Mar 6.

Department of Materials Engineering, Federal University of São Carlos, São Carlos 13565-905, São Paulo, Brazil,

Background: Nanophase surface properties of titanium alloys must be obtained for a suitable biological performance, particularly to facilitate cell adhesion and bone tissue formation. Obtaining a bulk nanostructured material using severe plastic deformation is an ideal processing route to improve the mechanical performance of titanium alloys. By decreasing the grain size of a metallic material, a superior strength improvement can be obtained, while surface modification of a nanostructured surface can produce an attractive topography able to induce biological responses in osteoblastic cells. Read More

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http://dx.doi.org/10.2147/IJN.S197099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408917PMC
March 2019
1 Read

A perspective on magnetic core-shell carriers for responsive and targeted drug delivery systems.

Int J Nanomedicine 2019 6;14:1707-1723. Epub 2019 Mar 6.

Materials Science and Technology Program, College of Arts and Sciences, Qatar University, Doha, Qatar,

Magnetic core-shell nanocarriers have been attracting growing interest owing to their physicochemical and structural properties. The main principles of magnetic nanoparticles (MNPs) are localized treatment and stability under the effect of external magnetic fields. Furthermore, these MNPs can be coated or functionalized to gain a responsive property to a specific trigger, such as pH, heat, or even enzymes. Read More

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http://dx.doi.org/10.2147/IJN.S193981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408922PMC

Erratum: NAC-loaded electrospun scaffolding system with dual compartments for the osteogenesis of rBMSCs in vitro [Erratum].

Authors:

Int J Nanomedicine 2019 5;14:1705. Epub 2019 Mar 5.

[This corrects the article on p. 787 in vol. 14, PMID: 30774333. Read More

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http://dx.doi.org/10.2147/IJN.S206291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407902PMC

Assessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products.

Int J Nanomedicine 2019 5;14:1687-1703. Epub 2019 Mar 5.

Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 10617, Republic of China,

Background: No systematic investigations have been conducted to assess the lung burden imposed by the chronic inhalation of silver nanoparticles (AgNPs) emitted by spray products.

Objective: The objective of this study was to formulate a study framework that integrates a probabilistic risk assessment scheme with a mechanistic lung burden model for the estimation of health risks associated with the long-term inhalation of AgNP-containing spray products.

Materials And Methods: A compartmentalized physiologically based alveolar deposition (PBAD) model was used to estimate AgNP lung burden. Read More

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http://dx.doi.org/10.2147/IJN.S171510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407905PMC

Nanoporous solid-state membranes modified with multi-wall carbon nanotubes with anti-biofouling property.

Int J Nanomedicine 2019 5;14:1669-1685. Epub 2019 Mar 5.

Department of Pathology, Yasuj University of Medical Sciences, Yasuj 7591741417, Iran.

Purpose: Nanoporous membranes have been employing more than before in applications such as biomedical due to nanometer hexagonal pores array. Biofouling is one of the important problems in these applications that used nanoporous membranes and are in close contact with microorganisms. Surface modification of the membrane is one way to prevent biofilm formation; therefore, the membrane made in this work is modified with carbon nanotubes. Read More

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http://dx.doi.org/10.2147/IJN.S189728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407906PMC
March 2019
1 Read

Preparation, intestinal segment stability, and mucoadhesion properties of novel thymopentin-loaded chitosan derivatives coated with poly (n-butyl) cyanoacrylate nanoparticles.

Int J Nanomedicine 2019 4;14:1659-1668. Epub 2019 Mar 4.

Department of Pharmacy, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China,

Background: In order to develop a promising carrier for the oral delivery of proteins and peptide drugs, a novel bioadhesive nanocarrier of chitosan (CTS) derivatives coated with poly (n-butyl) cyanoacrylate nanoparticles (PBCA-NPs) was prepared in this study.

Methods: Three different thymopentin (TP5)-loaded nanoparticles were prepared in the present study. TP5-PBCA-NPs were developed by modifying an emulsion polymerization method, and CTS and chitosan-glutathione (CG) derivative-coated PBCA nanoparticles were obtained from the electrostatic interactions between CTS or CG with negatively charged PBCA nanoparticles. Read More

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http://dx.doi.org/10.2147/IJN.S194529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404670PMC
March 2019
2 Reads

A review of small molecules and drug delivery applications using gold and iron nanoparticles.

Int J Nanomedicine 2019 11;14:1633-1657. Epub 2019 Mar 11.

Department of Chemical Engineering, 313 Snell Engineering Center, Northeastern University, Boston, MA, USA,

Conventional cancer treatment techniques show several limitations including low or no specificity and consequently a low efficacy in discriminating between cancer cells and healthy cells. Recent nanotechnology developments have introduced smart and novel therapeutic nanomaterials that take advantage of various targeting approaches. The use of nanotechnology in medicine and, more specifically, drug delivery is set to spread even more rapidly than it has over the past two decades. Read More

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http://dx.doi.org/10.2147/IJN.S184723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417854PMC
March 2019
3 Reads

Solid lipid nanoparticles with enteric coating for improving stability, palatability, and oral bioavailability of enrofloxacin.

Int J Nanomedicine 2019 1;14:1619-1631. Epub 2019 Mar 1.

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan Hubei, China,

Background: The poor palatability, variable oral bioavailability, stimulation to gastric mucosa, and light instability limited the application of enrofloxacin (ENR). The enteric granules combining solid lipid nanoparticles (SLNs) with enteric coating were explored to overcome these disadvantages.

Materials And Methods: ENR-loaded SLNs were produced by a hot homogenization and ultrasonic emulsification method and the enteric granules with SLNs as inner core were prepared by wet granulation followed by coating using polyacrylic resin II (PRII). Read More

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http://dx.doi.org/10.2147/IJN.S183479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402439PMC
March 2019
1 Read

Acid-responsive nanoparticles as a novel oxidative stress-inducing anticancer therapeutic agent for colon cancer.

Int J Nanomedicine 2019 28;14:1597-1618. Epub 2019 Feb 28.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China,

Objective: Nanoparticles can efficiently carry and deliver anticancer agents to tumor sites. Mounting evidence indicates that many types of cancer cells, including colon cancer, have a weakly acidic microenvironment and increased levels of reactive oxygen species. The construction of nano drug delivery vehicles "activatable" in response to the tumor microenvironment is a new antitumor therapeutic strategy. Read More

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http://dx.doi.org/10.2147/IJN.S189923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400122PMC
February 2019

Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats.

Int J Nanomedicine 2019 1;14:1587-1595. Epub 2019 Mar 1.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia,

Background: Apremilast (APM) is a novel, orally administered small molecule drug approved for treatment of psoriasis or psoriatic arthritis. Due to its low solubility and permeability, it is classified as a class IV drug according to BCS classification. Dose titration is recommended during APM treatment due to its tolerability and twice-daily dosing regimen issues. Read More

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http://dx.doi.org/10.2147/IJN.S195048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402442PMC
March 2019
1 Read

Biofunctional core-shell polypyrrole-polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer.

Int J Nanomedicine 2019 28;14:1575-1585. Epub 2019 Feb 28.

Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University and International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan,

Background: Polymeric delivery systems have been elucidated over the last few years as an approach of achieving high therapeutic effect to the local site of malignant disease patients who have cancer. Polypyrrole (Ppy) is a potential organic conducting polymer which has long been recognized as a versatile material due to its excellent stability, conductive properties, and great absorbance in the range of near-infrared (NIR). It is tremendously versatile for use in various biomedical fields such as cancer therapy. Read More

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http://dx.doi.org/10.2147/IJN.S163299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400129PMC
February 2019

Acute physiological changes caused by complement activators and amphotericin B-containing liposomes in mice.

Int J Nanomedicine 2019 26;14:1563-1573. Epub 2019 Feb 26.

Nanomedicine Research and Education Center, Institute of Pathophysiology, Semmelweis University, Budapest, Hungary,

Purpose: Undesirable complement (C) activation by nanomedicines can entail an adverse immune reaction known as C activation-related pseudoallergy (CARPA) in sensitive patients. The syndrome includes cardiopulmonary, hemodynamic, and a variety of other physiological changes that have been well described in man, pigs, dogs, and rats. However, the information on CARPA is scarce and ambiguous in mice, a species widely used in preclinical studies. Read More

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http://dx.doi.org/10.2147/IJN.S187139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396670PMC
February 2019
9 Reads

Preparation and optimization of lidocaine transferosomal gel containing permeation enhancers: a promising approach for enhancement of skin permeation.

Int J Nanomedicine 2019 26;14:1551-1562. Epub 2019 Feb 26.

Department of Pharmaceutics and Industrial Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

Aim: To develop the topical gel containing transferosomal lidocaine as alternative to painful local anesthetic injection.

Materials And Methods: The transfersomes were prepared by film hydration technique using soybean phosphatidylcholine and cholesterol. The prepared transfersomes were evaluated for the morphology, drug loading, %EE, particle size and in vitro release. Read More

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https://www.dovepress.com/preparation-and-optimization-of-li
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http://dx.doi.org/10.2147/IJN.S201356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396669PMC
February 2019
3 Reads

Multifunctional PLGA-based nanoparticles as a controlled release drug delivery system for antioxidant and anticoagulant therapy.

Int J Nanomedicine 2019 26;14:1533-1549. Epub 2019 Feb 26.

Department of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan,

Background: Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as HO and leads to vascular thrombosis, which causes tissue damage.

Purpose: In this investigation, poly (lactideco-glycolide) (PLGA)-based nanoparticles are used for their anticoagulant and antioxidant properties in vascular therapy.

Methods: Both heparin and glutathione are entrapped on PLGA-stearylamine nanoparticles by layer-by-layer interactions. Read More

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http://dx.doi.org/10.2147/IJN.S174962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396665PMC
February 2019
1 Read

Confined growth of multiple gold nanorices in dual-mesoporous silica nanospheres for improved computed tomography imaging and photothermal therapy.

Int J Nanomedicine 2019 25;14:1519-1532. Epub 2019 Feb 25.

Laboratory of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China,

Introduction: In this work, we have developed a novel "confined-growth" strategy to synthesize PEGylated multiple gold nanorices-encapsulated dual-mesoporous silica nanospheres (designated as PEGylated MGNRs@DMSSs) containing both small mesopores (2.5 nm) in the shell and large mesopores (21.7 nm) in the core based on a well-established, seed-mediated growth method. Read More

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http://dx.doi.org/10.2147/IJN.S184192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396883PMC
February 2019

Mitoxantrone-preloaded water-responsive phospholipid-amorphous calcium carbonate hybrid nanoparticles for targeted and effective cancer therapy.

Int J Nanomedicine 2019 25;14:1503-1517. Epub 2019 Feb 25.

Department of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China,

Background: The application of mitoxantrone (MIT) in cancer therapy has been severely limited by its inherent drawbacks. In addition, effective cancer therapy calls for drug release systems capable of enforcing drug release within cancer cells in response to infinite stimulant with enhanced drug penetration capability.

Methods: MIT-preloaded phospholipid-amorphous calcium carbonate hybrid nanoparticles (PL/ACC-MIT) that surface modified with PL shell (containing shielding polymer polyethylene glycol and targeting moiety folic acid) were prepared by a facile solvent-diffusion method. Read More

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http://dx.doi.org/10.2147/IJN.S193976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396884PMC
February 2019

Mesoporous silica nanoparticles as a delivery system for improving antiangiogenic therapy.

Int J Nanomedicine 2019 25;14:1489-1501. Epub 2019 Feb 25.

Eye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China,

Purpose: Antiangiogenic drugs usually have short-acting efficacy and poor treatment compliance. The purpose of this study was to determine whether mesoporous silica nanoparticles (MSNs) could be utilized as a nanodrug delivery system for improving antiangiogenic therapy.

Materials And Methods: MSN-encapsulated bevacizumab nanoparticles were prepared by the nanocasting strategy and characterized by Fourier transform infrared, transmission electron microscopy, and Brunauer-Emmett-Teller method. Read More

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http://dx.doi.org/10.2147/IJN.S195504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396882PMC
February 2019