4,510 results match your criteria International Journal of Nanomedicine[Journal]


An efficient and long-acting local anesthetic: ropivacaine-loaded lipid-polymer hybrid nanoparticles for the control of pain.

Int J Nanomedicine 2019 31;14:913-920. Epub 2019 Jan 31.

Department of Anesthesiology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China,

Purpose: Local anesthetics are used clinically for the control of pain following operation (including gastrointestinal surgery) or for the management of other acute and chronic pain. This study aimed to develop a kind of lipid-polymer hybrid nanoparticles (LPNs), which were constructed using poly(ethylene glycol)-distearoylphosphatidylethanolamine (PEG-DSPE) as the hydrophilic lipid shell and poly-ε-caprolactone (PCL) as the hydrophobic polymeric core.

Methods: Ropivacaine (RPV) was entrapped in the LPNs (RPV-LPNs) and the physicochemical and biochemical properties such as size, zeta potential, drug release, and cytotoxicity were studied. Read More

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http://dx.doi.org/10.2147/IJN.S190164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362966PMC
January 2019

Amorphous aggregation of tau in the presence of titanium dioxide nanoparticles: biophysical, computational, and cellular studies.

Int J Nanomedicine 2019 31;14:901-911. Epub 2019 Jan 31.

Department of Nanotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran,

Background: Nanoparticles (NPs) when injected into the body can reach target tissues like nervous system and interact with tau proteins and neurons. This can trigger conformational changes of tau and may affect NP toxicity.

Methods: In this study, we used several biophysical techniques (extrinsic and intrinsic fluorescence spectroscopy, circular dichroism (CD) spectroscopy, ultraviolet (UV)-visible spectroscopy), transmission electron microscopy (TEM) investigations, molecular docking and molecular dynamics studies, and cellular assays [3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) and flow cytometry) to reveal how structural changes of tau protein can change the cytotoxicity of titanium dioxide (TiO) NPs against neuron-like cells (SH-SY5Y) cells. Read More

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http://dx.doi.org/10.2147/IJN.S194658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362919PMC
January 2019

Tc-radiolabeled composites enabling in vivo imaging of arterial dispersal and retention of microspheres in the vascular network of rabbit lungs, liver, and liver tumors.

Int J Nanomedicine 2019 31;14:889-900. Epub 2019 Jan 31.

Research and Development, Sirtex Medical Limited, Sydney, NSW, Australia.

Purpose: Selective internal radiation therapy (SIRT) is an effective treatment option for liver tumors, using Y-90-loaded polymer microspheres that are delivered via catheterization of the hepatic artery. Since Y-90 is a beta emitter and not conveniently imaged by standard clinical instrumentation, dosimetry is currently evaluated in each patient using a surrogate particle, Technetium-labeled macroaggregated albumin (Tc-MAA). We report a new composite consisting of Tc-labeled nanoparticles attached to the same polymer microspheres as used for SIRT, which can be imaged with standard SPECT. Read More

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http://dx.doi.org/10.2147/IJN.S187153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362927PMC
January 2019

High loads of nano-hydroxyapatite/graphene nanoribbon composites guided bone regeneration using an osteoporotic animal model.

Int J Nanomedicine 2019 29;14:865-874. Epub 2019 Jan 29.

Institute of Science and Technology, Brasil University, Itaquera 08230-030, São Paulo, Brazil,

Background: It has been difficult to find bioactive compounds that can optimize bone repair therapy and adequate osseointegration for people with osteoporosis. The nano-hydroxyapatite (nHAp)/carbon nanotubes with graphene oxides, termed graphene nanoribbons (GNR) composites have emerged as promising materials/scaffolds for bone regeneration due to their bioactivity and osseointegration properties. Herein, we evaluated the action of nHAp/GNR composites (nHAp/GNR) to promote bone regeneration using an osteoporotic model. Read More

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http://dx.doi.org/10.2147/IJN.S192456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361224PMC
January 2019

Effects of triptolide and methotrexate nanosuspensions on left ventricular remodeling in autoimmune myocarditis rats.

Int J Nanomedicine 2019 29;14:851-863. Epub 2019 Jan 29.

Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA,

Purpose: This study was carried out to investigate the effects of a triptolide (TP) nanosuspension and methotrexate (MTX) nanosuspension on left ventricular remodeling and cardiac function for autoimmune myocarditis (EAM) in rats. The regulating effects on inflammatory cytokines in the peripheral serum and related mechanisms are also discussed.

Methods: First, TP and MTX were prepared as a nanosuspension, and the EAM model was successfully established in rats with cardiac myosin. Read More

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http://dx.doi.org/10.2147/IJN.S191267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361222PMC
January 2019

A highly sensitive biosensor based on Au NPs/rGO-PAMAM-Fc nanomaterials for detection of cholesterol.

Int J Nanomedicine 2019 25;14:835-849. Epub 2019 Jan 25.

Department of Clinical Laboratory, Chun'an First People's Hospital (Zhejiang Provincial People's Hospital Chun'an Branch), Hangzhou, Zhejiang, China,

Objective: This study aimed to construct a biosensor using Au nanoparticles (Au NPs) and reduced graphene-polyamide-amine-ferrocene (rGO-PAMAM-Fc) nanomaterials designed for rapid and sensitive detection of cholesterol.

Materials And Methods: In this study, a highly sensitive biosensor based on Au NPs/ rGO-PAMAM-Fc nanomaterials was manufactured for detection of cholesterol. The rGO-PAMAM-Fc and Au NPs were modified on the surface of the electrode and then coated with cholesterol oxidase (ChOx) and cholesterol esterase (ChEt) to develop the ChOx&ChEt/Au NPs/rGO-PAMAM-Fc biosensor. Read More

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http://dx.doi.org/10.2147/IJN.S184013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354697PMC
January 2019

Green synthesis of multifunctional PEG-carboxylate π back-bonded gold nanoconjugates for breast cancer treatment.

Int J Nanomedicine 2019 25;14:819-834. Epub 2019 Jan 25.

Department of Inorganic Chemistry, University of Madras, Guindy Campus, Chennai 600025, India,

Background: Surface functionalization of gold nanoparticles (AuNPs) has emerged as a promising field of research with enormous biomedical applications. The folate (FA)-attached polymer-gold nanoconjugates play vital role in targeting the cancer cells.

Methods: AuNPs were synthesized by using di- or tri-carboxylate-polyethylene glycol (PEG) polymers, including citrate-PEG (CPEG), malate-PEG (MAP), and tartrate-PEG (TAP), as a reducing and stabilizing agent. Read More

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http://dx.doi.org/10.2147/IJN.S190946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354699PMC
January 2019

Development of biosurfactant-based graphene quantum dot conjugate as a novel and fluorescent theranostic tool for cancer.

Int J Nanomedicine 2019 25;14:809-818. Epub 2019 Jan 25.

Biotechnology Engineering, University Institute of Engineering & Technology, Panjab University, Chandigarh, India,

Background: Biosurfactants are amphipathic molecules of microbial origin that reduce surface and interfacial tension at gas-liquid-solid interfaces. Earlier, the biosurfactant was isolated and characterized in our laboratory from . The property of the biosurfactant is further explored in this study by using quantum dots (QDs) as nanocarrier. Read More

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http://dx.doi.org/10.2147/IJN.S188552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354693PMC
January 2019

Effect of superparamagnetic nanoparticles coated with various electric charges on α-synuclein and β-amyloid proteins fibrillation process.

Int J Nanomedicine 2019 23;14:799-808. Epub 2019 Jan 23.

National Institute of Genetic Engineering and Biotechnology, Tehran, Iran,

Background: Most of nanoparticles are nontoxic and have high absorption capability. Therefore, nanoparticles binding can effectively restrain fibrillation of β-amyloid and α-synuclein proteins and eventually prevent the toxicity of pathogenesis peptide of Alzheimer. Super paramagnetic iron oxide nanoparticles (SPIONs) contain iron oxide core which can be connected to a special part through magnetic coating. Read More

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http://dx.doi.org/10.2147/IJN.S190354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361412PMC
January 2019

NAC-loaded electrospun scaffolding system with dual compartments for the osteogenesis of rBMSCs in vitro.

Int J Nanomedicine 2019 23;14:787-798. Epub 2019 Jan 23.

Center for Smart Materials and Devices, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, Hubei, China,

Purpose: In this study, we aimed to develop a unique -acetyl cysteine (NAC)-loaded polylactic-co-glycolic acid (PLGA) electrospun system with separate compartments for the promotion of osteogenesis.

Materials And Methods: We first prepared solutions of NAC-loaded mesoporous silica nanoparticles (MSNs), PLGA, and NAC in , -dimethylformamide and tetrahydrofuran for the construction of the electrospun system. We then fed solutions to a specific injector for electrospinning. Read More

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http://dx.doi.org/10.2147/IJN.S183233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361317PMC
January 2019

Pemetrexed-loaded nanoparticles targeted to malignant pleural mesothelioma cells: an in vitro study.

Int J Nanomedicine 2019 23;14:773-785. Epub 2019 Jan 23.

Department of Internal Medicine, Pneumology Unit, University of Pavia, Pavia, Italy.

Purpose: Malignant pleural mesothelioma (MPM) is an aggressive tumor characterized by poor prognosis. Its incidence is steadily increasing due to widespread asbestos exposure. There is still no effective therapy for MPM. Read More

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http://dx.doi.org/10.2147/IJN.S186344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361319PMC
January 2019

Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin- chitosan nanoparticles loading paclitaxel- cholesterol complex.

Int J Nanomedicine 2019 23;14:689-705. Epub 2019 Jan 23.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P.R. China,

Background: Intratumoral injection is a palliative treatment that aims at further improvement in the survival and quality of life of patients with advanced or recurrent carcinomas, or cancer patients with severe comorbidities or those with a poor performance status.

Methods: In this study, a solvent-injection method was used to prepare paclitaxel-cholesterol complex-loaded lecithin-chitosan nanoparticles (PTX-CH-loaded LCS_NPs) for intratumoral injection therapy, and the physicochemical properties of NPs were well characterized.

Results: The particle size and zeta potential of PTX-CH-loaded LCS_NPs were 142. Read More

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http://dx.doi.org/10.2147/IJN.S188667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361321PMC
January 2019

A multifunctional-targeted nanoagent for dual-mode image-guided therapeutic effects on ovarian cancer cells.

Int J Nanomedicine 2019 21;14:753-769. Epub 2019 Jan 21.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China,

Purpose: Nanomedicine has emerged as a novel therapeutic modality for cancer treatment and diagnosis. Lipid-polymer hybrid nanoparticles (LPHNPs) are core-shell nanoparticle (NP) structures comprising polymer cores and lipid shells, which exhibit complementary characteristics of both polymeric NPs and liposomes. However, it is difficult to wrap perfluoropentane (PFP) into core-shell NPs in the existing preparation process, which limits its application in the integration of diagnosis and treatment. Read More

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http://dx.doi.org/10.2147/IJN.S187929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345190PMC
January 2019
1 Read

Enhanced bone regeneration of the silk fibroin electrospun scaffolds through the modification of the graphene oxide functionalized by BMP-2 peptide.

Int J Nanomedicine 2019 18;14:733-751. Epub 2019 Jan 18.

Department of Prosthodontics, Oral Bioengineering and Regenerative Medicine Lab, Shanghai Key Laboratory of Stomatology, Ninth People's Hospital Affiliated to Shanghai JiaoTong University, School of Medicine, Shanghai 200011, China,

Introduction: Bone tissue engineering has become one of the most effective methods to treat bone defects. Silk fibroin (SF) is a natural protein with no physiological activities, which has features such as good biocompatibility and easy processing and causes minimal inflammatory reactions in the body. Scaffolds prepared by electrospinning SF can be used in bone tissue regeneration and repair. Read More

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http://dx.doi.org/10.2147/IJN.S187664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342216PMC
January 2019
1 Read

An anti-inflammatory peptide and brain-derived neurotrophic factor-modified hyaluronan-methylcellulose hydrogel promotes nerve regeneration in rats with spinal cord injury.

Int J Nanomedicine 2019 18;14:721-732. Epub 2019 Jan 18.

Institute of TBI and Neuroscience, Characteristic Medical Center of Chinese People's Armed Police Force (PAP), Tianjin Key Laboratory of Neurotrauma Repair, Tianjin 300162, China,

Background: Traumatic spinal cord injury (SCI) causes neuronal death, demyelination, axonal degeneration, inflammation, glial scar formation, and cystic cavitation resulting in interruption of neural signaling and loss of nerve function. Multifactorial targeted therapy is a promising strategy for SCI.

Methods: The anti-inflammatory peptide KAFAKLAARLYRKALARQLGVAA (KAFAK) and brain-derived neurotrophic factor (BDNF)-modified hyaluronan-methylcellulose (HAMC) hydrogel was designed for minimally invasive, localized, and sustained intrathecal protein delivery. Read More

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http://dx.doi.org/10.2147/IJN.S187854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342221PMC
January 2019
1 Read

Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy.

Int J Nanomedicine 2019 18;14:707-719. Epub 2019 Jan 18.

Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China,

Hypoxia is a common feature of most solid tumors. Having a comprehensive understanding of tumor hypoxia condition is a key to tumor therapy. Many hypoxia imaging nanoparticles have been used for tumor detection. Read More

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http://dx.doi.org/10.2147/IJN.S192048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342223PMC
January 2019

Silver nanoparticles: aggregation behavior in biorelevant conditions and its impact on biological activity.

Int J Nanomedicine 2019 18;14:667-687. Epub 2019 Jan 18.

Department of Applied and Environmental Chemistry, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary,

Purpose: The biomedical applications of silver nanoparticles (AgNPs) are heavily investigated due to their cytotoxic and antimicrobial properties. However, the scientific literature is lacking in data on the aggregation behavior of nanoparticles, especially regarding its impact on biological activity. Therefore, to assess the potential of AgNPs in therapeutic applications, two different AgNP samples were compared under biorelevant conditions. Read More

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http://dx.doi.org/10.2147/IJN.S185965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342213PMC
January 2019

Synergistic effects of liposomes encapsulating atorvastatin calcium and curcumin and targeting dysfunctional endothelial cells in reducing atherosclerosis.

Int J Nanomedicine 2019 15;14:649-665. Epub 2019 Jan 15.

PCFM Lab of Ministry of Education, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, People's Republic of China,

Background: Atherosclerosis is a major cardiovascular disease that causes ischemia of the heart, brain, or extremities, and can lead to infarction. The hypolipidemic agent atorvastatin calcium (Ato) alleviates atherosclerosis by reducing plasma lipid and inflammatory factors. However, the low bioavailability of Ato limits its widespread use and clinical effectiveness. Read More

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https://www.dovepress.com/synergistic-effects-of-liposomes-e
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http://dx.doi.org/10.2147/IJN.S189819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339643PMC
January 2019
2 Reads

A comparison of poly-ethylene-glycol-coated and uncoated gold nanoparticle-mediated hepatotoxicity and oxidative stress in Sprague Dawley rats.

Int J Nanomedicine 2019 15;14:639-647. Epub 2019 Jan 15.

NIH-RCMI Center for Environmental Health, College of Science Engineering and Technology, Jackson State University, Jackson, MS, 39217, USA,

Background: Gold nanoparticles (GNPs) and their functional derivatives are of great interest because of their many biomedical applications. GNPs are increasingly being incorporated into new diagnostic and therapeutic approaches in medicine. Consequently, there has been a strong push to fully understand their interactions with blood components. Read More

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http://dx.doi.org/10.2147/IJN.S185574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339646PMC
January 2019

The synthesis and application of nano doxorubicin- indocyanine green matrix metalloproteinase-responsive hydrogel in chemophototherapy for head and neck squamous cell carcinoma.

Int J Nanomedicine 2019 15;14:623-638. Epub 2019 Jan 15.

Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, China,

Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies, with high rates of mortality and morbidity worldwide. Owing to the special anatomical location of this tumor, an effective, minimally invasive treatment with low systemic toxicity is highly desirable. Hydrogels have shown great potential for tumor-targeting therapy, with excellent performance. Read More

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http://dx.doi.org/10.2147/IJN.S191069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339648PMC
January 2019
1 Read

Designing and enhancing the antifungal activity of corneal specific cell penetrating peptide using gelatin hydrogel delivery system.

Int J Nanomedicine 2019 15;14:605-622. Epub 2019 Jan 15.

Department of Nanobiotechnology, Vision Research Foundation, Sankara Nethralaya campus, Chennai, Tamil Nadu, India,

Background: Fungal keratitis is a major cause of corneal blindness accounting for more than one-third of microbiologically proven cases. The management of fungal keratitis is through topical or systemic antifungal medications alone or in combination with surgical treatment. Topical medications such as natamycin and voriconazole pose major challenges due to poor penetration across the corneal epithelium. Read More

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http://dx.doi.org/10.2147/IJN.S184911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339655PMC
January 2019

Ultrasmall gold nanorods: synthesis and glycocalyx-related permeability in human endothelial cells.

Int J Nanomedicine 2019 17;14:319-333. Epub 2019 Jan 17.

Department of Chemical Engineering, Northeastern University, Boston,MA, USA,

Background: Clinical data show shed endothelial glycocalyx (GCX) components in blood samples of atherosclerotic patients, linking atherosclerotic development to endothelial GCX integrity. Healthy GCX has pores no >7 nm, and shed GCX has even larger pores. Therefore, we suggest targeting and treating atherosclerosis-prone blood vessels by using nanoscale vehicles to deliver drugs via the nanoscale GCX as it becomes dysfunctional. Read More

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http://dx.doi.org/10.2147/IJN.S184455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340363PMC
January 2019
1 Read

High drug payload nanoparticles formed from dexamethasone-peptide conjugates for the treatment of endotoxin-induced uveitis in rabbit.

Int J Nanomedicine 2019 14;14:591-603. Epub 2019 Jan 14.

Institute of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, People's Republic of China,

Purpose: To develop and demonstrate the effectiveness of a novel dexamethasone (Dex) nanoformulation for treating uveitis.

Materials And Methods: We designed and screened a dexamethasone-peptide conjugate (Dex-SA-FFFE), formed via a biodegradable ester bond linkage, that could spontaneously form high drug payload nanoparticles in aqueous solution for treating uveitis.

Results: An in vitro release study indicated that Dex and Dex-SA-FFFE sustainably released from Dex-SA-FFFE nanoparticles over a 48 h study period. Read More

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https://www.dovepress.com/high-drug-payload-nanoparticles-fo
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http://dx.doi.org/10.2147/IJN.S179118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336024PMC
January 2019
4 Reads

Iron oxide nanoparticles promote the migration of mesenchymal stem cells to injury sites.

Int J Nanomedicine 2019 14;14:573-589. Epub 2019 Jan 14.

Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People's Republic of China,

Background: Developing new methods to deliver cells to the injured tissue is a critical factor in translating cell therapeutics research into clinical use; therefore, there is a need for improved cell homing capabilities.

Materials And Methods: In this study, we demonstrated the effects of labeling rat bone marrow-derived mesenchymal stem cells (MSCs) with fabricated polydopamine (PDA)-capped FeO (FeO@PDA) superparticles employing preassembled FeO nanoparticles as the cores.

Results: We found that the FeO@PDA composite superparticles exhibited no adverse effects on MSC characteristics. Read More

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https://www.dovepress.com/iron-oxide-nanoparticles-promote-t
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http://dx.doi.org/10.2147/IJN.S184920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336032PMC
January 2019
5 Reads

Novel self-nanomicellizing solid dispersion based on rebaudioside A: a potential nanoplatform for oral delivery of curcumin.

Int J Nanomedicine 2019 11;14:557-571. Epub 2019 Jan 11.

Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China,

Purpose: Rebaudioside A (RA) has nanocarrier characteristics that allow it to self-assemble into micelles in aqueous solutions. The purpose of this study was to determine if a self-nanomicellizing solid dispersion based on RA could be utilized as an oral nano-drug delivery system.

Materials And Methods: Curcumin (Cur) served as a model hydrophobic drug, and a Cur-loaded self-nanomicellizing solid dispersion based on RA (RA-Cur) was formulated. Read More

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https://www.dovepress.com/novel-self-nanomicellizing-solid-d
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http://dx.doi.org/10.2147/IJN.S191337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333391PMC
January 2019
11 Reads

Idarubicin-loaded methoxy poly(ethylene glycol)--poly(l-lactide-co-glycolide) nanoparticles for enhancing cellular uptake and promoting antileukemia activity.

Int J Nanomedicine 2019 11;14:543-556. Epub 2019 Jan 11.

Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang 325000, China,

Purpose: Nanoparticle (NP)-based drug delivery approaches have tremendous potential for enhancing treatment efficacy and decreasing doses of chemotherapeutics. Idarubicin (IDA) is one of the most common chemotherapeutic drugs used in the treatment of acute myeloid leukemia (AML). However, severe side effects and drug resistance markedly limit the application of IDA. Read More

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http://dx.doi.org/10.2147/IJN.S190027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333394PMC
January 2019
2 Reads

Drug-loaded exosomal preparations from different cell types exhibit distinctive loading capability, yield, and antitumor efficacies: a comparative analysis.

Int J Nanomedicine 2019 11;14:531-541. Epub 2019 Jan 11.

Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA,

Background: Despite tremendous advancement, cancer still remains one of the leading causes of death worldwide. Inefficiency of current drug delivery regimens is one important factor that limits the therapeutic efficacy of existing drugs, thus contributing to cancer mortality. To address this limitation, synthetic nanotechnology-based delivery systems have been developed; however, they raise concern of inducing adverse immunogenic reactions. Read More

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http://dx.doi.org/10.2147/IJN.S191313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333392PMC
January 2019
1 Read

Perfluorohexane-encapsulated fullerene nanospheres for dual-modality US/CT imaging and synergistic high-intensity focused ultrasound ablation.

Int J Nanomedicine 2019 11;14:519-529. Epub 2019 Jan 11.

The Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, People's Republic of China,

Purpose: The objective of this study was to develop a multifunctional contrast agent for bioimaging and synergistic high-intensity focused ultrasound (HIFU) therapy to achieve theranostic.

Materials And Methods: A novel type of perfluorohexane-encapsulated fullerene (PFH-C) nanosphere was successfully developed via a vacuum ultrasonic emulsification and centrifugation method and subsequently used in ultrasound/computed tomography (CT) dual-modality and HIFU ablation of dissected bovine livers. In addition, transmission electron microscopic examination was employed to detect structural changes in the target tissue for HIFU ablation. Read More

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https://www.dovepress.com/perfluorohexane-encapsulated-fulle
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http://dx.doi.org/10.2147/IJN.S184579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333388PMC
January 2019
5 Reads

Liquid crystalline assembly for potential combinatorial chemo-herbal drug delivery to lung cancer cells.

Int J Nanomedicine 2019 11;14:499-517. Epub 2019 Jan 11.

Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt,

Background: Lung cancer is the most common cancer and the leading cause of total deaths worldwide. Its classified into two major types including non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC) based on the origin of abnormal lung cells as well as the smoking status of the patient. NSCLC is the most common and aggressive type of lung cancer representing 80%-85% of all cases. Read More

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http://dx.doi.org/10.2147/IJN.S188335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333390PMC
January 2019
2 Reads

Preparation and biological characterization of the mixture of poly(lactic-co-glycolic acid)/chitosan/Ag nanoparticles for periodontal tissue engineering.

Int J Nanomedicine 2019 11;14:483-498. Epub 2019 Jan 11.

Department of Stomatology, Zhongshan Hospital of Xiamen University, Medical College of Xiamen University, Xiamen University, Xiamen 361000, China,

Objective: This study aims to produce nanoparticles of chitosan (CS), poly(lactic-co-glycolic acid) (PLGA), and silver and investigate the optimal composite ratio of these three materials for periodontal tissue regeneration.

Methods: PLGA nanoparticles (nPLGA), CS nanoparticles (nCS), and silver nanoparticles (nAg) were prepared. The antibacterial properties of single nanoparticles and their effects on the proliferation and mineralization of periodontal membrane cells were investigated. Read More

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http://dx.doi.org/10.2147/IJN.S184396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333395PMC
January 2019
1 Read

Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections.

Int J Nanomedicine 2019 11;14:469-481. Epub 2019 Jan 11.

Department of Nursing, Chang Gung University of Science and Technology, Puzi City, Chiayi County 61363, Taiwan,

Background: Periprosthetic joint infections (PJIs) have a high incidence of recurrence after total joint replacement and are difficult to treat by debridement or antibiotic treatment. Curcumin is a natural product with anti-inflammatory and anti-bacterial properties. The low bioactivity of curcumin in water restricts its clinical application. Read More

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https://www.dovepress.com/curcumin-nanoparticles-are-a-promi
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http://dx.doi.org/10.2147/IJN.S191504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333393PMC
January 2019
5 Reads

Biocompatibility evaluation of antibacterial Ti-Ag alloys with nanotubular coatings.

Int J Nanomedicine 2019 10;14:457-468. Epub 2019 Jan 10.

Department of Sports Medicine, Huashan Hospital of Fudan University, Shanghai 200040, China,

Background: Implant-related infection is a major problem postsurgery. As an alternative to a localized antibiotic release system, we used Ag to fabricate Ti-Ag alloys with nanotubular coatings (TiAg-NTs). Ag has excellent antibacterial properties, but its biological toxicity is a concern. Read More

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https://www.dovepress.com/biocompatibility-evaluation-of-ant
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http://dx.doi.org/10.2147/IJN.S193569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330981PMC
January 2019
3 Reads

Nanotubular TiO regulates macrophage M2 polarization and increases macrophage secretion of VEGF to accelerate endothelialization via the ERK1/2 and PI3K/AKT pathways.

Int J Nanomedicine 2019 10;14:441-455. Epub 2019 Jan 10.

Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China,

Background: Macrophages play important roles in the immune response to, and successful implantation of, biomaterials. Titanium nanotubes are considered promising heart valve stent materials owing to their effects on modulation of macrophage behavior. However, the effects of nanotube-regulated macrophages on endothelial cells, which are essential for stent endothelialization, are unknown. Read More

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https://www.dovepress.com/nanotubular-tio2-regulates-macroph
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http://dx.doi.org/10.2147/IJN.S188439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330985PMC
January 2019
5 Reads

Surface-enhanced Raman spectroscopy before radical prostatectomy predicts biochemical recurrence better than CAPRA-S.

Int J Nanomedicine 2019 9;14:431-440. Epub 2019 Jan 9.

Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People's Republic of China,

Objective: The objective of this study was to evaluate the performance of surface-enhanced Raman spectroscopy (SERS) in the prediction of early biochemical recurrence after radical prostatectomy (RP).

Patients And Methods: We synthesized monodisperse gold nanoparticles as SERS-enhanced substrates and analyzed preoperative plasma samples of patients who underwent RP. The roles of clinical risk model (Cancer of the Prostate Risk Assessment [CAPRA] score) and distinctive SERS spectra on prediction of early biochemical recurrence were evaluated. Read More

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http://dx.doi.org/10.2147/IJN.S186226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331067PMC
January 2019
1 Read

Biodegradable andrographolide-eluting nanofibrous membranes for the treatment of cervical cancer.

Int J Nanomedicine 2019 9;14:421-429. Epub 2019 Jan 9.

Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan,

Background: In this study, we developed biodegradable andrographolide (AG)-eluting nanofibrous mats and evaluated their efficacy in treating cervical cancer.

Materials And Methods: Membranes of two different poly[(d,l)-lactide--glycolide] (PLGA)-to-AG ratios (6:1 and 3:1) were prepared via electrospinning technology. The liberation behavior of AG was evaluated. Read More

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https://www.dovepress.com/biodegradable-andrographolide-elut
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http://dx.doi.org/10.2147/IJN.S186714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331077PMC
January 2019
6 Reads

Improved smallest peptides based on positive charge increase of the γ-core motif from D and their mechanism of action against species.

Int J Nanomedicine 2019 9;14:407-420. Epub 2019 Jan 9.

Laboratório de Fisiologia e Bioquímica de Microrganismos, Centro de Biociências e Biotecnologia, Universidade Estadualdo Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro, Brazil,

Background: Plant defensins have a hallmark γ-core motif (GXCXC) that is related to their antimicrobial properties. The aim of this work was to design synthetic peptides based on the region corresponding to the D defensin γ-core that are the smallest amino acid sequences that bear the strongest biological activity.

Methods: We made rational substitutions of negatively charged amino acid residues with positively charged ones, and the reduction in length in the selected D γ-core sequence to verify whether the increased net positive charges and shortened length are related to the increase in antifungal activity. Read More

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http://dx.doi.org/10.2147/IJN.S187957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331069PMC
January 2019
1 Read

Assessment of in vivo genotoxicity of citrated-coated silver nanoparticles via transcriptomic analysis of rabbit liver tissue.

Int J Nanomedicine 2019 8;14:393-405. Epub 2019 Jan 8.

Institute of Environmental Medicine for Green Chemistry, Dongguk University Biomedi Campus, Ilsandong-gu, Goyang-si, Republic of Korea,

Background: Silver nanoparticles (AgNPs) are widely used in industrial and household applications, arousing concern regarding their safety in humans. The risks posed by stabilizer-coated AgNPs continue to be unclear, and assessing their toxicity is for an understanding of the safety issues involved in their use in various applications.

Purpose: We aimed to investigated the long-term toxicity of citrate-coated silver nanoparticles (cAgNPs) in liver tissue using several toxicity tests and transcriptomic analysis at 7 and 28 days after a single intravenous injection into rabbit ear veins (n=4). Read More

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https://www.dovepress.com/assessment-of-in-vivo-genotoxicity
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http://dx.doi.org/10.2147/IJN.S174515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329348PMC
February 2019
3 Reads

The impact of camptothecin-encapsulated poly(lactic--glycolic acid) nanoparticles on the activity of cytochrome P450 in vitro.

Int J Nanomedicine 2019 7;14:383-391. Epub 2019 Jan 7.

Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China,

Background: Poly(lactic--glycolic acid) (PLGA) has emerged as a promising anticancer drug delivery scaffold. Camptothecin (CPT) has been fabricated into a variety of nanosized formulations to improve drug action. We report an experimental study on the effect of CPT-encapsulated PLGA (PLGA-CPT) nanoparticles (NPs) on drug-metabolizing cytochrome P450 enzyme, CYP3A4. Read More

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http://dx.doi.org/10.2147/IJN.S188984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327902PMC
January 2019

In situ graphene liquid cell-transmission electron microscopy study of insulin secretion in pancreatic islet cells.

Int J Nanomedicine 2019 7;14:371-382. Epub 2019 Jan 7.

Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA,

Background: Islet cell transplantation is one of the key treatments for type 1 diabetes. Understanding the mechanisms of insulin fusion and exocytosis are of utmost importance for the improvement of the current islet cell transplantation and treatment of diabetes. These phenomena have not been fully evaluated due either to the lack of proper dynamic imaging, or the lack of proper cell preservation during imaging at nanoscales. Read More

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https://www.dovepress.com/in-situ-graphene-liquid-cell-trans
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http://dx.doi.org/10.2147/IJN.S169506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327893PMC
January 2019
10 Reads

Novel redispersible nanosuspensions stabilized by co-processed nanocrystalline cellulose-sodium carboxymethyl starch for enhancing dissolution and oral bioavailability of baicalin.

Int J Nanomedicine 2019 3;14:353-369. Epub 2019 Jan 3.

Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,

Background: To improve the dissolution and bioavailability of poorly soluble drugs, novel nanosuspensions using co-processed nanocrystalline cellulose-sodium carboxymethyl starch (NCCS) as a synergetic stabilizer were first designed.

Methods: Co-processed NCCS was prepared by means of homogenization. Poorly soluble baicalin (BCA) was used as a model drug. Read More

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https://www.dovepress.com/novel-redispersible-nanosuspension
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http://dx.doi.org/10.2147/IJN.S184374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322498PMC
February 2019
4 Reads

Phycocyanin/PEG--(PG--PEI) attenuated hepatic ischemia/reperfusion-induced pancreatic islet injury and enlarged islet functionality.

Int J Nanomedicine 2019 3;14:339-351. Epub 2019 Jan 3.

Department of Pharmaceutical Chemistry, Medical College, Shantou University, Shantou, PR China.

Background: Hepatic ischemia/reperfusion-induced pancreatic islet injury (HI/RIPII) was an important pathophysiological phenomenon in clinics. In the present study, we observed the effects of phycocyanin on HI/RIPII. However, the half-life of phycocyanin was extremely short and limited its use in vivo. Read More

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http://dx.doi.org/10.2147/IJN.S190938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322515PMC
February 2019

Erratum: From 3D spheroids to tumor bearing mice: efficacy and distribution studies of trastuzumab-docetaxel immunoliposome in breast cancer [Erratum].

Authors:

Int J Nanomedicine 2019 31;14:335. Epub 2018 Dec 31.

[This corrects the article on p. 6677 in vol. 13, PMID: 30425482. Read More

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http://dx.doi.org/10.2147/IJN.S197654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319424PMC
December 2018

Co-delivery doxorubicin and silybin for anti-hepatoma via enhanced oral hepatic-targeted efficiency.

Int J Nanomedicine 2019 28;14:301-315. Epub 2018 Dec 28.

Drug Delivery Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, People's Republic of China,

Background: To establish the combination of doxorubicin (DOX) and silybin (SLB) in oral hepatic-targeting liposomes with the goal of reducing cardiotoxic side effects and improve oral hepatoma treatment.

Methods: Distearoylphosphatidylethanolamine-polyethylene glycol-cholic acid-modified liposomes (CA-LP) were used to encapsulate DOX and SLB (CA-LP-DOX/SLB), and the hepatic targeting, efficacy against hepatoma and cardioprotective effects were evaluated by cell toxicity, scratch and apoptosis in vitro studies, and pharmacokinetics and pharmacodynamics in vivo studies.

Results: In vitro cell studies showed that CA-LP-DOX/SLB inhibited HepG2 cell proliferation and HCC97H cell migration, and protected H9c2 cells. Read More

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https://www.dovepress.com/co-delivery-doxorubicin-and-silybi
Publisher Site
http://dx.doi.org/10.2147/IJN.S187888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314320PMC
February 2019
7 Reads

Silver sulfadiazine nanosuspension-loaded thermosensitive hydrogel as a topical antibacterial agent.

Int J Nanomedicine 2019 28;14:289-300. Epub 2018 Dec 28.

Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, People's Republic of China,

Background: Silver sulfadiazine (AgSD) is widely employed as an antibacterial agent for surface burn management. However, the antibacterial activity of AgSD was restrained because of the lower drug solubility and possible cytotoxicity.

Objective: This study aimed to formulate stable silver sulfadiazine/nanosuspensions (AgSD/NSs) with improved AgSD solubility and prepare a suitable carrier for AgSD/NS delivery. Read More

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http://dx.doi.org/10.2147/IJN.S187918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314312PMC
February 2019
6 Reads

Large-scale synthesis of monodisperse Prussian blue nanoparticles for cancer theranostics via an "in situ modification" strategy.

Int J Nanomedicine 2019 27;14:271-288. Epub 2018 Dec 27.

Department of Ultrasound in Medicine, Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China,

Background: The intrinsic properties of Prussian blue (PB) nanoparticles make them an attractive tool in nanomedicine, including magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and photothermal therapy (PTT) properties. However, there still remains the challenge of their poor dispersible stability in the physiological environment. In this study, we developed an efficient hydrothermal method to address the poor dispersible stability of PB nanoparticles in the physiological environment. Read More

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http://dx.doi.org/10.2147/IJN.S183858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312061PMC
February 2019
2 Reads

Albumin binding and anticancer effect of magnesium oxide nanoparticles.

Int J Nanomedicine 2019 27;14:257-270. Epub 2018 Dec 27.

Department of Nanotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran,

Background: Recently, nanomaterials have moved into biological and medicinal implementations like cancer therapy. Therefore, before clinical trials, their binding to plasma proteins like human serum albumin (HSA) and their cytotoxic effects against normal and cancer cell lines should be addressed.

Methods: Herein, the interaction of magnesium oxide nanoparticles (MgO NPs) with HSA was studied by means of fluorescence spectroscopy, circular dichroism (CD) spectroscopy, and docking studies. Read More

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https://www.dovepress.com/albumin-binding-and-anticancer-eff
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http://dx.doi.org/10.2147/IJN.S186428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312066PMC
February 2019
7 Reads

Albumin binding, anticancer and antibacterial properties of synthesized zero valent iron nanoparticles.

Int J Nanomedicine 2019 28;14:243-256. Epub 2018 Dec 28.

Department of Nanotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran,

Background: Nanoparticles (NPs) have been emerging as potential players in modern medicine with clinical applications ranging from therapeutic purposes to antimicrobial agents. However, before applications in medical agents, some in vitro studies should be done to explore their biological responses.

Aim: In this study, protein binding, anticancer and antibacterial activates of zero valent iron (ZVFe) were explored. Read More

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https://www.dovepress.com/albumin-binding-anticancer-and-ant
Publisher Site
http://dx.doi.org/10.2147/IJN.S188497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314318PMC
February 2019
7 Reads