484,247 results match your criteria International Journal of MS Care[Journal]


Predictive Value of Age-Bilirubin-International Normalized Ratio-Creatinine Score in Short-Term Survival of Acute-on-Chronic Hepatitis B Liver Failure.

Cell Physiol Biochem 2018 11;51(5):2484-2495. Epub 2018 Dec 11.

Department of Hepatic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangdong, China.

Background/aims: The age-bilirubin-international normalized ratio-creatinine (ABIC) score, which is a predictive model commonly used for alcoholic hepatitis, has not yet been studied in acute-on-chronic hepatitis B liver failure (HBV-ACLF). We aimed to investigate the predictive value of the ABIC score in patients with HBV-ACLF.

Methods: This retrospective study involved 398 patients diagnosed with HBV-ACLF, who were divided into a training cohort of 305 patients and a validation cohort of 93 patients. Read More

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December 2018

Renal Functions and Prognosis Stratification in Chronic Heart Failure Patients and the Importance of Neutrophil Gelatinase-Associated Lipocalin.

Kidney Blood Press Res 2018 Dec 7;43(6):1865-1877. Epub 2018 Dec 7.

Department of Internal Cardiology Medicine, Faculty Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Background/aims: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients. Read More

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December 2018

A review of methods used for hazard identification and risk assessment of environmental hazards.

Environ Int 2018 Dec 8;123:231-239. Epub 2018 Dec 8.

Department of Innovation, Evidence and Research, World Health Organization, Av. Appia 20 CH-1211, Geneva 27, Switzerland. Electronic address:

Background: Approximately one quarter of all deaths globally are attributed to living or working in an unhealthy environment, with household and ambient air pollution, along with exposures to ultraviolet radiation and chemicals amongst the leading causes. At present there are no international standards for assessing the risks of these environmental hazards. The use of heterogeneous methods to identify health risks from environmental hazards may reduce the level of confidence the public has in the conclusions that are made. Read More

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December 2018

3‑Bromo‑5‑(ethoxymethyl)‑1,2‑benzenediol inhibits LPS-induced pro-inflammatory responses by preventing ROS production and downregulating NF-κB in vitro and in a zebrafish model.

Int Immunopharmacol 2018 Dec 8;67:98-105. Epub 2018 Dec 8.

Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Republic of Korea. Electronic address:

The anti-inflammatory effects of 3‑bromo‑5‑(ethoxymethyl)‑1,2‑benzenediol (BEMB) from Polysiphonia morrowii were evaluated in lipopolysaccharide (LPS)-induced RAW264.7 cells and zebrafish embryo. BEMB showed anti-inflammatory effects by inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS), and the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in the LPS-activated RAW264. Read More

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December 2018

Disentangling the effect of out-of-home care on child mental health.

Child Abuse Negl 2018 Dec 8;88:189-200. Epub 2018 Dec 8.

Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, LE1 7RH, England, United Kingdom. Electronic address:

Background: Children in out-of-home care are consistently found to have poor mental health compared to children in the general population. However, UK research has so far failed to disentangle the impact of the care system on children's mental health outcomes from the effects of the adverse circumstances that led to their admission to care.

Objective: This research investigated the association between care placement and the presence of child mental health problems after controlling for children's pre-care experiences. Read More

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December 2018

Metabolic and biochemical responses of Potamogeton anguillanus Koidz. (Potamogetonaceae) to low oxygen conditions.

J Plant Physiol 2018 Nov 23;232:171-179. Epub 2018 Nov 23.

Graduate School of Science and Engineering, Saitama University, 255 Shimo-Okubo, Sakura-ku, Saitama 338-8570, Japan; Research Institute of Chuo University, Kasuga, Bunkyo, Tokyo 112-8551, Japan. Electronic address:

Oxygen availability in water is considered one of the most important factors for growth and productivity in aquatic submerged macrophytes. In the present study, the growth, stress responses, and metabolic changes in Potamogeton anguillanus Koidz. (Potamogetonaceae) were assessed after a 21-day exposure to low (hypoxia; dissolved oxygen, DO < 1 mg/L) or null (anoxia) oxygen concentrations in water. Read More

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November 2018

Analysis of Single Nucleotide Polymorphisms in the Gamma Block of the Major Histocompatibility Complex in Association with Clinical Outcomes of Hematopoietic Cell Transplantation: A CIBMTR Study.

Biol Blood Marrow Transplant 2018 Dec 8. Epub 2018 Dec 8.

Cleveland Clinic Foundation, Cleveland, OH.

HLA haplotype mismatches have been associated with higher risk of acute graft versus host disease (aGVHD) in patients receiving HLA matched unrelated donor (URD) hematopoietic cell transplant (HCT) unrelated donors. The Gamma block (GB) is located in the central MHC region between beta and delta blocks (encoding C & B and DR & DQ antigens, respectively). GB contains many inflammatory and immune regulatory genes such as Bf, C2 and C4 genes. Read More

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December 2018

Allicin enhances antimicrobial activity of macrophages during Mycobacterium tuberculosis infection.

J Ethnopharmacol 2018 Dec 8. Epub 2018 Dec 8.

Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India. Electronic address:

Ethnopharmacological Relevance: The emergence of drug-resistant Mycobacterium tuberculosis (M.tb) strains has severely hampered global efforts towards tuberculosis (TB) eradication. The internationally accepted therapy "Directly Observed Treatment Short-course (DOTS)" is lengthy, and incorporates risks for the generation of drug-resistant M. Read More

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December 2018
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Devil's hand conceals behind the obscure side of AgNPs: A letter to the editor.

Authors:
Hassan Rasouli

Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.

Medical Biology Research Center (MBRC), Kermanshah University of Medical Science, Kermanshah, Iran. Electronic address:

From that time AgNPs become one of the most accessible and important antibacterial agents in our world, thousands of papers published regarding investigating all aspects of these materials. When the time elapsed and novel methods contrived to follow the fingerprint of AgNPs in the in vivo models, some critical concerns and arguments also appeared between researchers about the safety of these compounds for living cells. The paper by Dehvari and Ghahaghaei published in Volume 108 International Journal of Biological Macromolecules, pages 1128-1139 (Dehvari and Ghahghaei, 2018) suffered from some errors from safety concerns to obscurities in the results and the application of paper for applicable uses in medicine or elsewhere. Read More

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December 2018
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Cross-border and domestic surrogacy in the UK context: an exploration of practical and legal decision-making.

Hum Fertil (Camb) 2018 Dec 11:1-12. Epub 2018 Dec 11.

b NGA Law and Brilliant Beginnings , London , UK.

This study aimed to explore UK intending parent's reasons for cross-border and domestic surrogacy, their preparations for the birth and the practical and legal challenges faced after the birth. An online survey was completed by 203 participants, of which 132 had a child born through surrogacy, 33 were in the process of surrogacy and 38 were planning a surrogacy arrangement. The most common reason for pursuing surrogacy in the UK was wanting a relationship with the surrogate (43%; n = 17) and for conducting surrogacy in the USA was because of a better legal framework (97%; n = 60). Read More

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December 2018

The value of immunotherapy in head and neck cancer.

Expert Opin Biol Ther 2018 Dec 11. Epub 2018 Dec 11.

d Marlene and Stewart Greenebaum Comprehensive Cancer Center , University of Maryland School of Medicine , Baltimore , Maryland.

Introduction: Head and neck squamous cell carcinomas (HNSCC) previously had limited treatment options once patients had progressed on systemic chemotherapy. With recent advances, immunotherapy now plays an important role in the treatment of advanced disease with improved outcomes as compared to cytotoxic chemotherapy. Areas covered: This article reviews the effects of the immune system and how it influences the development and response to HNSCC therapy. Read More

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December 2018
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Nomenclature of cutaneous vasculitides - German translation of the dermatologic addendum to the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides.

J Dtsch Dermatol Ges 2018 Dec;16(12):1425-1432

Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria.

The nomenclature system agreed upon by the Chapel Hill Consensus Conference (CHCC) with respect to the terminology and precise definition of the various types of vasculitis has gained widespread interdisciplinary and international acceptance. As the revised version from 2012 (CHCC 2012) does not address the special features of vasculitis of the skin, it has recently been supplemented with an addendum containing the nomenclature of cutaneous vasculitides (D-CHCC). The present article provides the German translation of the terms and defintions of the D-CHCC as well as additional explanatory comments. Read More

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December 2018
1 Read

Utility and implications of exome sequencing in early-onset Parkinson's disease.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

Background: Although the genetic load is high in early-onset Parkinson's disease, thorough investigation of the genetic diagnostic yield has yet to be established. The objectives of this study were to assess variants in known genes for PD and other movement disorders and to find new candidates in 50 patients with early-onset PD.

Methods: We searched for variants either within genes listed by the International Parkinson and Movement Disorder Society Task Force on Genetic Nomenclature or rare homozygous variants in novel candidate genes. Read More

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December 2018

Physical activity energy expenditure and cardiometabolic health in three rural Kenyan populations.

Am J Hum Biol 2018 Dec 10:e23199. Epub 2018 Dec 10.

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Objectives: Physical activity is beneficial for metabolic health but the extent to which this may differ by ethnicity is still unclear. Here, the objective was to characterize the association between physical activity energy expenditure (PAEE) and cardiometabolic risk among the Luo, Kamba, and Maasai ethnic groups of rural Kenya.

Methods: In a cross-sectional study of 1084 rural Kenyans, free-living PAEE was objectively measured using individually-calibrated heart rate and movement sensing. Read More

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December 2018

Fieldwork after conflict: contextualising the challenges of access and data quality.

Disasters 2018 Dec 10. Epub 2018 Dec 10.

Lecturer, Department of International Politics, City, University of London, United Kingdom.

Despite sustained scholarly interest in post-conflict states, there has not been a thorough review and analysis of associated methodology and the challenges of conducting research in these contexts. Addressing this gap, this paper directs attention to the particular effects of these settings on access and data quality and their ramifications for the resulting scholarship. It assesses the intrinsic challenges of performing fieldwork in these environments, drawing on both relevant social science literature and the authors' experiences of carrying out research in Afghanistan and Timor-Leste. Read More

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December 2018
1 Read

A versatile synthetic route to the preparation of N heterocycles.

J Labelled Comp Radiopharm 2018 Dec 11. Epub 2018 Dec 11.

International Tomography Center SB RAS, Novosibirsk, Russia.

A robust medium-scale (~3 g) synthetic method for N labeling of pyridine ( N-Py) is reported based on the Zincke reaction. N enrichment in excess of 81% was achieved with ~33% yield. N-Py serves as a standard substrate in a wide range of studies employing a hyperpolarization technique for efficient polarization transfer from parahydrogen to heteronuclei; this technique, called SABRE (Signal Amplification by Reversible Exchange), employs a simultaneous chemical exchange of parahydrogen and to-be-hyperpolarized substrate (e. Read More

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December 2018
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Spectrofluorimetric determination of eptifibatide in human plasma and dosage form.

Luminescence 2018 Dec 11. Epub 2018 Dec 11.

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El- Aini Street, Cairo, Egypt.

A spectrofluorimetric method for the determination of eptifibatide is presented based on its native fluorescence. The type of solvent and the wavelength of maximum excitation and emission were carefully selected to optimize the experimental conditions. Under the specified experimental conditions, the linearities obtained between the emission intensity and the corresponding concentrations of eptifibatide were in the range 0. Read More

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December 2018
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High expression of LASS2 is associated with unfavorable prognosis in patients with ovarian cancer.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.

Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2), is a gene isolated from a human liver complementary DNA library. In this study, we found that LASS2 protein level was positively related to International Federation of Gynecology and Obstetrics (FIGO) stage and LASS2-negative tumors showed significant association with longer disease-free survival (DFS) and overall survival (OS) in ovarian cancer patients. The heterogeneous expression of LASS2 had been exhibited in diverse ovarian cancer cells. Read More

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December 2018

Role of ADHD in the Co-occurrence between Heavy Alcohol Use and Depression Trajectories in Adulthood.

Alcohol Clin Exp Res 2018 Dec 10. Epub 2018 Dec 10.

University of Pittsburgh, Medical Center Department of Psychiatry.

Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with greater heavy alcohol use and depressive symptoms in adulthood. Yet, few studies have investigated whether childhood ADHD predicts an increased association between heavy drinking and depression in adulthood when this co-occurrence becomes more common. We examined associations among heavy alcohol use and depression longitudinally from ages 21 to 29 and whether these associations differed for those with or without childhood ADHD, as well as for those with or without persistent ADHD in adulthood. Read More

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December 2018

Need to address gaps in global fisheries observation.

Conserv Biol 2018 Dec 11. Epub 2018 Dec 11.

University of Queensland School of Earth and Environmental Sciences, Level 2, Steele Building (3), Room 210, Brisbane, Australia, 4072.

Article impact statement: Urgent gaps in global fisheries monitoring can be addressed with more strategic use of government funds and regional assistance programs. This article is protected by copyright. All rights reserved. Read More

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December 2018

The risk of cancer attributable to diagnostic medical radiation: Estimation for France in 2015.

Int J Cancer 2018 Dec 8. Epub 2018 Dec 8.

Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France, 69372.

Although medical ionizing radiation (IR) has clear clinical benefits, it is an established carcinogen. This study estimates the number of new cancer cases in France in 2015 attributable to IR exposure from medical procedures. Exposures from external (X-rays, CT scans, interventional radiology) and internal (nuclear medicine) sources were considered. Read More

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December 2018

Oscillatory dynamics of cortical functional connections in semantic prediction.

Hum Brain Mapp 2018 Dec 7. Epub 2018 Dec 7.

MEG and Cortical Networks Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

An event related potential, known as the N400, has been particularly useful in investigating language processing as it serves as a neural index for semantic prediction. There are numerous studies on the functional segregation of N400 neural sources; however, the oscillatory dynamics of functional connections among the relevant sources has remained elusive. In this study we acquired magnetoencephalography data during a classic N400 paradigm, where the semantic predictability of a fixed target noun was manipulated in simple German sentences. Read More

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December 2018

Implantable cardiac defibrillators for people with non-ischaemic cardiomyopathy.

Cochrane Database Syst Rev 2018 Dec 8;12:CD012738. Epub 2018 Dec 8.

Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Background: There is evidence that implantable cardioverter-defibrillator (ICD) for primary prevention in people with an ischaemic cardiomyopathy improves survival rate. The evidence supporting this intervention in people with non-ischaemic cardiomyopathy is not as definitive, with the recently published DANISH trial finding no improvement in survival rate. A systematic review of all eligible studies was needed to evaluate the benefits and harms of using ICDs for primary prevention in people with non-ischaemic cardiomyopathy. Read More

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December 2018

Microglial cell activation and senescence are characteristic of the pathology FXTAS.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

MIND Institute, UC Davis Medical Center, Sacramento, California, USA.

Background: Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder associated with premutation alleles of the FMR1 gene. Expansions of more than 200 CGG repeats give rise to fragile X syndrome, the most common inherited form of cognitive impairment. Fragile X-associated tremor/ataxia syndrome is characterized by cerebellar tremor and ataxia, and the presence of ubiquitin-positive inclusions in neurons and astrocytes. Read More

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December 2018
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Nigral iron deposition in common tremor disorders.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurology, Medical University of Graz, Graz, Austria.

Objective: We investigated R2* relaxation rates as a marker of iron content in the substantia nigra in patients with common tremor disorders and explored their diagnostic properties.

Methods: Mean nigral R2* rates were measured in 40 patients with tremor-dominant Parkinson's disease (PD), 15 with tremor in dystonia, 25 with essential tremor, and 25 healthy controls.

Results: Tremor-dominant PD patients had significantly higher nigral R2* values (34. Read More

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December 2018

Reply to "Comments on the TRS-483 Protocol on Small field Dosimetry" [Med. Phys. 45(12), 5666-5668 (2018)].

Med Phys 2018 Dec;45(12):5669-5671

Dosimetry and Medical Radiation Physics Section, International Atomic Energy Agency, A-1400, Vienna, Austria.

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December 2018

Ting-Kai Li: In Memoriam.

Alcohol Clin Exp Res 2018 Dec 10. Epub 2018 Dec 10.

Indiana University School of Medicine, Dept. of Biochemistry and Molecular Biology, 635 Barnhill Drive, MS4063, Indianapolis, Indiana.

Ting-Kai (T-K) Li, MD died on November 18, 2018, just five days after his 84 birthday. T-K had a wonderful and distinguished academic and public service career, spanning almost five decades. Born in Nanjing, China, T-K fled with his family to South Africa during World War II, while a young boy. Read More

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December 2018

Effects of Angelica gigas Nakai on the production of decursin- and decursinol angelate-enriched eggs.

J Sci Food Agric 2018 Dec 7. Epub 2018 Dec 7.

Institute of Green-Bio Science and Technology, Seoul National University, Pyeongchang-gun, Gangwon-do 25354, Korea.

Background: The livestock industry requires high-quality products as well as improved productivity. There have been many studies regarding the utilization of feed additives to increase productivity, enhance immune functions, and prevent infectious diseases in livestock. Biofunctional feed additives would be beneficial not only for animal health, but also for consumers. Read More

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December 2018
1 Read

Angioplasty versus stenting for infrapopliteal arterial lesions in chronic limb-threatening ischaemia.

Cochrane Database Syst Rev 2018 Dec 8;12:CD009195. Epub 2018 Dec 8.

Department of Medical Imaging, Gold Coast University Hospital, 1 Hospital Blvd, Southport, Queensland, Australia, 4215.

Background: Chronic limb-threatening ischaemia (CLTI) is a manifestation of peripheral arterial disease (PAD) that includes chronic ischaemic rest pain or ischaemic skin lesions, ulcers, or gangrene for longer than two weeks. The severity of the disease depends on the extent of arterial stenosis and the availability of collateral circulation. Treatment for CLTI aims to relieve ischaemic pain, heal ischaemic ulcers, prevent limb loss, improve quality of life, and prolong survival. Read More

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December 2018
1 Read

Highly sensitive spectrofluorimetric method for rapid determination of orciprenaline in biological fluids and pharmaceuticals.

Luminescence 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Pharmacy, Pharmaceutical Analytical Chemistry Department, Mansoura University, Mansoura, Egypt.

Orciprenaline sulphate (ORP) is a direct-acting sympathomimetic with mainly beta-adrenoceptor stimulant activity. It is used as a bronchodilator in the management of reversible airway obstruction. For the first time, a rapid highly sensitive spectrofluorimetric method is described that is relied on measuring the fluorescence spectra of ORP at acidic pH and without addition of any chemical reagents. Read More

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December 2018

The effects of incretin-based therapies on beta-cell function and insulin resistance in type 2 diabetes: a systematic review and network meta-analysis combining 360 trials.

Diabetes Obes Metab 2018 Dec 9. Epub 2018 Dec 9.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China.

Aim: To evaluate the comparative effects of incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 inhibitors (DPP-4Is), on beta-cell function and insulin resistance in patients with type 2 diabetes mellitus (T2DM).

Materials And Methods: Medline, Embase, the Cochrane Library and www.clinicaltrials. Read More

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December 2018

Disruption of the default mode network and its intrinsic functional connectivity underlies minor hallucinations in Parkinson's disease.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, Spain.

Background: Minor hallucinations and well-structured hallucinations are considered in the severity continuum of the psychotic spectrum associated with Parkinson's disease. Although their chronological relationship is largely unknown, the spatial patterns of brain atrophy in these 2 forms of hallucinations partially overlap, suggesting they share similar pathophysiological processes. Functional connectivity studies show that disruption of functional networks involved in perception and attention could be relevant in the emergence of well-structured hallucinations. Read More

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December 2018

Fasting insulin resistance affects the prevalence of metabolically healthy obesity in Brazilian adolescents.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Aim: We aimed to assess the influence of fasting insulin resistance on metabolically healthy obesity (MHO) prevalence in adolescents and to identify associated factors.

Methods: This retrospective, registry-based, cross-sectional study included 418 (51.9% girls) 10-18 year-old adolescents with obesity from a tertiary outpatient clinic in Sao Paulo, Brazil, between 2009 and 2013. Read More

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December 2018
2 Reads

Variability in the Diagnosis of Surgical Site Infections After Full-Thickness Skin Grafting: An International Survey.

Br J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden.

Background: Diagnosis of a surgical site infection (SSI) in dermatologic surgery can be entirely based on a subjective assessment according to the 4 criterion of the most common definition of an SSI, which was established by the US Centers for Disease Control (CDC).

Objectives: To investigate the interobserver agreement between dermatologists in their diagnosis of SSI of dermatosurgical wounds.

Methods: An international electronic photographic survey with eight photographs of wounds 1 week after full-thickness skin grafting (FTSG) was sent to dermatologists. Read More

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December 2018
1 Read

High-Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action.

Cytometry A 2018 Dec 11. Epub 2018 Dec 11.

Janssen Research & Development, Beerse, Belgium.

Daratumumab is a CD38-targeted human monoclonal antibody with direct anti-myeloma cell mechanisms of action. Flow cytometry in relapsed and/or refractory multiple myeloma (RRMM) patients treated with daratumumab revealed cytotoxic T-cell expansion and reduction of immune-suppressive populations, suggesting immune modulation as an additional mechanism of action. Here, we performed an in-depth analysis of the effects of daratumumab on immune-cell subpopulations using high-dimensional mass cytometry. Read More

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December 2018

A chemogenetic approach for treating experimental Parkinson's disease.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: PD is a common neurodegenerative disease primarily affecting the cortico-basal ganglia loop.

Objective: To investigate whether chemogenetic-mediated neuromodulation of various nuclei and pathways can counterbalance basal ganglia network abnormalities and improve motor disability in experimental PD.

Methods: Experimental PD was induced by stereotactic injection of 6-OHDA to the medial forebrain bundle. Read More

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December 2018

The array of clinical phenotypes of males with mutations in Methyl-CpG binding protein 2.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 7. Epub 2018 Dec 7.

University of Alabama at Birmingham, Birmingham, Alabama.

Mutations in the X-linked gene MECP2 are associated with a severe neurodevelopmental disorder, Rett syndrome (RTT), primarily in girls. It had been suspected that mutations in Methyl-CpG-binding protein 2 (MECP2) led to embryonic lethality in males, however such males have been reported. To enhance understanding of the phenotypic spectrum present in these individuals, we identified 30 males with MECP2 mutations in the RTT Natural History Study databases. Read More

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December 2018
1 Read

Label-Free Metabolic Classification of Single Cells in Droplets Using the Phasor Approach to Fluorescence Lifetime Imaging Microscopy.

Cytometry A 2018 Dec 11. Epub 2018 Dec 11.

Biomedical Engineering Department, University of California, Irvine, California.

Characterization of single cell metabolism is imperative for understanding subcellular functional and biochemical changes associated with healthy tissue development and the progression of numerous diseases. However, single-cell analysis often requires the use of fluorescent tags and cell lysis followed by genomic profiling to identify the cellular heterogeneity. Identifying individual cells in a noninvasive and label-free manner is crucial for the detection of energy metabolism which will discriminate cell types and most importantly critical for maintaining cell viability for further analysis. Read More

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December 2018

Promoting Electrocatalysis upon Aerogels.

Adv Mater 2018 Dec 9:e1804881. Epub 2018 Dec 9.

Physikalische Chemie, Technische Universität Dresden, Bergstraße 66b, 01062, Dresden, Germany.

Electrocatalysis plays a prominent role in renewable energy conversion and storage, enabling a number of sustainable processes for future technologies. There are generally three strategies to improve the efficiency (or activity) of the electrocatalysts: i) increasing the intrinsic activity of the catalyst itself, ii) improving the exposure of active sites, and iii) accelerating mass transfer during catalysis (both reactants and products). These strategies are not mutually exclusive and can ideally be addressed simultaneously, leading to the largest improvements in activity. Read More

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December 2018

Global wheat production with 1.5 and 2.0°C above pre-industrial warming.

Glob Chang Biol 2018 Dec 7. Epub 2018 Dec 7.

Agricultural & Biological Engineering Department, University of Florida, Gainesville, FL 32611, USA.

Efforts to limit global warming to below 2°C in relation to the pre-industrial level are under way, in accordance with the 2015 Paris Agreement. However, most impact research on agriculture to date has focused on impacts of warming >2°C on mean crop yields, and many previous studies did not focus sufficiently on extreme events and yield interannual variability. Here, with the latest climate scenarios from the Half a degree Additional warming, Prognosis and Projected Impacts (HAPPI) project, we evaluated the impacts of the 2015 Paris Agreement range of global warming (1. Read More

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December 2018
1 Read

Allocation of deceased donor kidneys: A review of international practices.

Nephrology (Carlton) 2018 Dec 10. Epub 2018 Dec 10.

Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.

The demand for kidney transplantation continues to exceed the availability of deceased donor kidneys. Balancing the overarching principles of the optimal use of (utility) and equal access to (equity) this scarce resource requires a sophisticated allocation system. This review will examine how various factors are addressed in allocation systems around the world to strike a balance between utility and equity. Read More

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December 2018
1 Read

Relevance of Polypharmacy for Clinical Outcome in Patients Receiving Vitamin K Antagonists.

J Am Geriatr Soc 2018 Dec 11. Epub 2018 Dec 11.

Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Background: Although polypharmacy is associated with a negative clinical outcome in various settings and commonly observed in patients receiving oral anticoagulation therapy, evidence on the relevance for the clinical outcome of anticoagulated patients is currently limited. The aim of the study was to investigate the effect of polypharmacy on the clinical outcomes among patients taking phenprocoumon.

Design: Prospective cohort study. Read More

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December 2018
2 Reads

LncRNA HOXA-AS2 positively regulates osteogenesis of mesenchymal stem cells through inactivating NF-κB signalling.

J Cell Mol Med 2018 Dec 8. Epub 2018 Dec 8.

Henan Joint International Research Laboratory of Stem Cell Medicine, College of Biomedical Engineering, Xinxiang Medical University, Xinxiang, China.

As is previously reported, mesenchymal stem cells have potential ability to differentiate into osteocytes. However, the underlying mechanism during this biological process is poorly understood. In the present study, we identify a novel long non-coding RNA named HOXA-AS2 as a critical regulator during the formation of osteogenesis. Read More

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December 2018

Ethics codes and use of new and innovative drugs.

Br J Clin Pharmacol 2018 Dec 9. Epub 2018 Dec 9.

Department of Clinical Immunology, Medical University of Warsaw, Nowogrodzka Str. 59, 02-006, Warsaw, Poland.

Treatment with new and/or innovative drugs with uncertain safety and efficacy profile is associated with substantial ethical concerns. The main objective of this paper is to present guidance on the use of such drugs contained in: 1) major international codes and guidelines pertaining to medical ethics and biomedical research; 2) national codes of medical ethics and professional conduct of the US, Canada, Australia, New Zealand, the UK, Ireland, France and Germany. Out of the four international codes and guidelines analyzed, only the Declaration of Helsinki addresses the question of the use of unproven drugs. Read More

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December 2018

Atrial fibrillation is highly prevalent yet undertreated in patients with biopsy-proven Nonalcoholic Steatohepatitis.

Liver Int 2018 Dec 7. Epub 2018 Dec 7.

Department of Preventive Medicine.

Background & Aims: Nonalcoholic steatohepatitis (NASH) is associated with increased cardiovascular disease. Atrial fibrillation is a prominent risk marker for underlying cardiovascular disease with a prevalence of 2% in patients < 65 years old. Atrial fibrillation prevalence in NASH is unknown. Read More

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December 2018

The diversity of population responses to environmental change.

Ecol Lett 2018 Dec 9. Epub 2018 Dec 9.

Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, F-69622, Villeurbanne, France.

The current extinction and climate change crises pressure us to predict population dynamics with ever-greater accuracy. Although predictions rest on the well-advanced theory of age-structured populations, two key issues remain poorly explored. Specifically, how the age-dependency in demographic rates and the year-to-year interactions between survival and fecundity affect stochastic population growth rates. Read More

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December 2018

Rapid Assessment of Mitochondrial Complex I Activity and Metabolic Phenotyping of Breast Cancer Cells by NAD(p)H Cytometry.

Cytometry A 2018 Dec 11. Epub 2018 Dec 11.

Metabolic Photonics Laboratory, Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, California, 90048.

Cancer cells are known to display a variety of metabolic reprogramming strategies to fulfill their own growth and proliferative agenda. With the advent of high resolution imaging strategies, metabolomics techniques, and so forth, there is an increasing appreciation of critical role that tumor cell metabolism plays in the overall breast cancer (BC) growth. In this report, we demonstrate a sensitive, flow-cytometry-based assay for rapidly assessing the metabolic phenotypes in isolated suspensions of breast cancer cells. Read More

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December 2018

Opioid receptors and opioid peptides in the cardiomyogenesis of mouse embryonic stem cells.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Free Radical Pathophysiology, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic.

The stimulation of myocardium repair is restricted due to the limited understanding of heart regeneration. Interestingly, endogenous opioid peptides such as dynorphins and enkephalins are suggested to support this process. However, the mechanism-whether through the stimulation of the regenerative capacity of cardiac stem cells or through effects on other cell types in the heart-is still not completely understood. Read More

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December 2018

Aicardi syndrome, an unsolved mystery: Review of diagnostic features, previous attempts, and future opportunities for genetic examination.

Am J Med Genet C Semin Med Genet 2018 Dec 10. Epub 2018 Dec 10.

Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

Aicardi syndrome is a rare, severe neurodevelopmental disorder classically characterized by the triad of infantile spasms, central chorioretinal lacunae, and agenesis of the corpus callosum. Aicardi syndrome only affects females, with the exception of a few males with a 47, XXY chromosome constitution. All cases are de novo and the only cases of definitive recurrence in families are in identical twins. Read More

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December 2018
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The role of Eomes in human CD4 T cell differentiation: A question of context.

Eur J Immunol 2018 Dec 7. Epub 2018 Dec 7.

CIRI, Centre International de Recherche en Infectiologie - International Center for Infectiology Research, Inserm, U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, CNRS, UMR5308, Lyon, France.

Eomesodermin (Eomes) is a transcription factor (TF) of the T-box family closely related to T-bet known for its role in CD8 T cell and natural killer cell differentiation. However, the role of Eomes in CD4 T-cell differentiation is less well appreciated. In this issue of the European Journal of Immunology [Eur. Read More

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December 2018
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