1,503 results match your criteria International Journal of Laboratory Hematology [Journal]


Unusual findings of acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): A multicenter study.

Int J Lab Hematol 2019 Feb 22. Epub 2019 Feb 22.

Department of Hematology, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China.

Introduction: AML with inv(3)(q21.3q26.2) or t(3;3)(q21. Read More

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http://dx.doi.org/10.1111/ijlh.12987DOI Listing
February 2019

Age- and sex-specific reference intervals for hematologic analytes in Chinese children.

Int J Lab Hematol 2019 Feb 20. Epub 2019 Feb 20.

Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Introduction: Reference intervals for pediatric laboratory tests need to be interpreted in the context of age- and sex-dependent dynamics. However, few reference intervals for healthy ethnic Han Chinese children have previously attempted to establish using large sample sizes. As such, there are no national hematological standards in China for pediatric reference intervals. Read More

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http://dx.doi.org/10.1111/ijlh.12979DOI Listing
February 2019

Standardization of reticulocyte counts in the athlete biological passport.

Int J Lab Hematol 2019 Feb 19. Epub 2019 Feb 19.

World Anti-Doping Agency, Lausanne, Switzerland.

Introduction: The percentage of circulating reticulocytes (RET%) is a useful marker of blood doping in the context of the Athlete Biological Passport (ABP). The viability of the ABP depends on the comparability of sample data obtained across multiple laboratories for a given athlete. With the recent introduction of a different technology for the measurement of reticulocytes, the goal of this study was to compare currently employed Sysmex XT/XE analyzers to the recently introduced Sysmex XN analyzer. Read More

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http://dx.doi.org/10.1111/ijlh.12988DOI Listing
February 2019

Comparison of the bone marrow trephine sample quality between OnControl drill system and the Jamshidi needle.

Int J Lab Hematol 2019 Feb 19. Epub 2019 Feb 19.

Department of Haematology, Canberra Hospital, Canberra, Australian Capital Territory, Australia.

Introduction: Bone marrow biopsies are a key diagnostic and monitoring intervention in haematology with manual bone marrow techniques the established method of choice. Powered biopsy devices are now available, but are not widely used in haematology. This study compared the quality of bone marrow trephines obtained with the Jamshidi needle and OnControl powered drill system. Read More

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http://dx.doi.org/10.1111/ijlh.12984DOI Listing
February 2019

CD56 natural killer cells exhibit abnormal phenotype and function in severe aplastic anemia.

Int J Lab Hematol 2019 Feb 19. Epub 2019 Feb 19.

Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.

Introduction: CD56 NK cells have been highlighted to serve immunoregulatory functions. However, their roles in severe aplastic anemia (SAA) have not been elucidated.

Methods: Here, we investigated the quantities, phenotypes, cytokine secretion abilities, and the cytotoxicities of peripheral CD56 NK cells along with CD56 NK cells obtained from patients with SAA, SAA in remission (R-SAA), and healthy controls (HC). Read More

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http://dx.doi.org/10.1111/ijlh.12982DOI Listing
February 2019

Lack of harmonization in high fluorescent cell automated counts with body fluids mode in ascitic, pleural, synovial, and cerebrospinal fluids.

Int J Lab Hematol 2019 Feb 13. Epub 2019 Feb 13.

Section of Clinical Biochemistry, University of Verona, Verona, Italy.

Introduction: Cellular analysis in body fluids (BFs) provides important diagnostic information in various pathological settings. This study was hence aimed at comparing automated cell count obtained with Mindray BC-6800 (BC-BF) vs Sysmex XN-series (XN-BF) and evaluating other quantitative and qualitative information provided by these analyzers in ascitic (AF), pleural (PF), synovial (SF), and cerebrospinal (CSF) fluids.

Methods: Three hundred and fifty-one samples (99 AFs, 45 PFs, 75 SFs, and 132 CSFs) were analyzed in parallel with BC-BF, XN-BF, and optical microscopy (OM). Read More

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http://doi.wiley.com/10.1111/ijlh.12968
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http://dx.doi.org/10.1111/ijlh.12968DOI Listing
February 2019
1 Read

Very unusual expression of multiple aberrant T-cell markers in plasmablastic plasma cell myeloma.

Int J Lab Hematol 2019 Feb 11. Epub 2019 Feb 11.

Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.

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http://dx.doi.org/10.1111/ijlh.12985DOI Listing
February 2019
1 Read

Evaluation of the detection of blasts by Sysmex hematology instruments, CellaVision DM96, and manual microscopy using flow cytometry as the confirmatory method.

Int J Lab Hematol 2019 Feb 11. Epub 2019 Feb 11.

Department of multidisciplinary laboratory medicine and medical biochemistry, Akershus University Hospital, Lørenskog, Norway.

Introduction: The aim of the present study was to evaluate the diagnostic ability of blast flags generated by Sysmex instruments (XE/XN) by comparing with immunophenotyping by flow cytometry (IFCM). Additionally, the ability of manual microscopy and CellaVision DM96 (pre- and reclassification) to predict the presence of "true" blasts was investigated.

Methods: Blood samples (n = 240) with suspect pathology flags reported by the XE were collected from the daily workload and examined by the XN, by manual microscopy, by CellaVision DM96 and by IFCM (CytoDiff Panel). Read More

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http://doi.wiley.com/10.1111/ijlh.12980
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http://dx.doi.org/10.1111/ijlh.12980DOI Listing
February 2019
11 Reads

Quantitative analysis of desmopressin (DDAVP) response in adult patients with type 1 von Willebrand disease.

Int J Lab Hematol 2019 Feb 8. Epub 2019 Feb 8.

Division of Hematology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.

Introduction: Patients with Type 1 von Willebrand disease (VWD) have reduced amounts of von Willebrand factor (VWF) in their blood. Desmopressin (DDAVP) has been used to raise the blood levels of VWF in these patients. However, not all patients with Type 1 VWD are known to respond to DDAVP therapy. Read More

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http://dx.doi.org/10.1111/ijlh.12978DOI Listing
February 2019
1 Read

Flow cytometric predictive scoring systems for common fusions ETV6/RUNX1, BCR/ABL1, TCF3/PBX1 and rearrangements of the KMT2A gene, proposed for the initial cytogenetic approach in cases of B-acute lymphoblastic leukemia.

Int J Lab Hematol 2019 Feb 7. Epub 2019 Feb 7.

Flow Cytometry Laboratory, Department of Immunology, Athens Regional General Hospital "G. Gennimatas", Athens, Greece.

Introduction: In B-acute lymphoblastic leukemia (B-ALL), the identification of cytogenetic prognostic factors is important for stratifying patients into risk groups and tailoring treatment accordingly. The purpose of this study was to propose flow cytometric (FCM) scoring systems (SSs) for predicting t(12;21)(p13;q22), t(9;22)(q34;q11), t(11q23), and t(1;19)(q23;p13.3) translocations. Read More

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http://dx.doi.org/10.1111/ijlh.12983DOI Listing
February 2019
2 Reads

Optimal wavelength for the clot waveform analysis: Determination of the best resolution with minimal interference of the reagents.

Int J Lab Hematol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium.

Introduction: Clot waveform analysis (CWA), a new methodology to assess coagulation process, can be usefully applied in various clinical settings. However, its clinical use is limited mainly because of the absence of standardization. No consensus exists regarding the wavelengths at which CWA has to be performed what is crucial for the sensitivity of the CWA. Read More

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http://doi.wiley.com/10.1111/ijlh.12975
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http://dx.doi.org/10.1111/ijlh.12975DOI Listing
February 2019
5 Reads

Very rare lineage switch from acute myeloid leukemia to mixed phenotype acute leukemia, B/Myeloid, during chemotherapy with no clonal evolution.

Int J Lab Hematol 2019 Feb 1. Epub 2019 Feb 1.

Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio.

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http://dx.doi.org/10.1111/ijlh.12977DOI Listing
February 2019
2 Reads

An in vitro study to investigate the interference of enoxaparin on plasma levels of direct oral factor Xa inhibitors measured by chromogenic assays.

Int J Lab Hematol 2019 Jan 30. Epub 2019 Jan 30.

Arianna Anticoagulazione Foundation, Bologna, Italy.

Introduction: Co-administration of enoxaparin and a direct oral factor Xa inhibitor (xabans: apixaban, edoxaban, rivaroxaban) could give rise to the problem of overlapping the anti-Xa activity when measuring direct oral anticoagulant (DOAC) levels. We aimed to evaluate in vitro the degree of the interference of increasing enoxaparin concentrations on xaban plasma levels measured by different chromogenic anti-Xa assays with drug-specific calibrators and controls.

Methods: Seven plasma samples were spiked with apixaban, edoxaban, or rivaroxaban at fixed concentration, and enoxaparin at increasing concentrations (0, 0. Read More

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http://dx.doi.org/10.1111/ijlh.12974DOI Listing
January 2019
1 Read

A pilot study to introduce a local external quality assurance scheme for D-dimers in the National Health Laboratory Service, in South Africa.

Int J Lab Hematol 2019 Jan 28. Epub 2019 Jan 28.

National Health Laboratory Service (NHLS), Department of Molecular Medicine and Haematology, University of the Witwatersrand (WITS), Johannesburg, South Africa.

Introduction: Laboratory quality assurance (QA) includes internal quality control (IQC), external quality assurance (EQA) and quality improvement (QI). EQA identifies quality deviations and training needs. D-dimers are breakdown products of thrombus and results guide various clinical decisions. Read More

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http://dx.doi.org/10.1111/ijlh.12973DOI Listing
January 2019
1 Read

Evaluation of the suitability of the World Health Organization International Reference Reagent for Hb A quantitation (89/666) for continued use.

Int J Lab Hematol 2019 Jan 20. Epub 2019 Jan 20.

Manchester Metropolitan University, Manchester, UK.

Introduction: The accurate determination of Hb A is a key marker when screening for a β-thalassaemia carrier. Data from external quality assessment (EQA) exercises have shown a lack of alignment of Hb A quantitation both within and between methods. The only reference material available for Hb A quantitative assay at the time of writing is the World Health Organization International Reference Reagent (89/666; WHO IRR) prepared in the 1980s and not validated for all current methodologies. Read More

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http://dx.doi.org/10.1111/ijlh.12966DOI Listing
January 2019
1 Read

Platelet satellitism around lymphocytes: Case report and literature review.

Int J Lab Hematol 2019 Jan 20. Epub 2019 Jan 20.

Clinical Laboratory, Core-Hematology Department, Laboratori Clínic Metropolitana Nord (LCMN), Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

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http://dx.doi.org/10.1111/ijlh.12972DOI Listing
January 2019

Utility of new red cell parameters for distinguishing functional iron deficiency from absolute iron deficiency in children with familial Mediterranean fever.

Int J Lab Hematol 2019 Jan 9. Epub 2019 Jan 9.

Department of Pediatric Rheumatology and Nephrology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Introduction: Few data are available on the clinical utility of new red cell parameters for detecting anemia in children with inflammatory diseases. The aim was to investigate the utility of three new red cell parameters for distinguishing functional iron deficiency (FID) from absolute iron deficiency (AID) in children with familial Mediterranean fever (FMF).

Methods: The study involved 198 children with genetically confirmed FMF and 18 healthy-age and sex-matched controls. Read More

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http://doi.wiley.com/10.1111/ijlh.12971
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http://dx.doi.org/10.1111/ijlh.12971DOI Listing
January 2019
5 Reads

Acute myeloid leukemia with t(10;11)(p11-12;q23.3): Results of Russian Pediatric AML registration study.

Int J Lab Hematol 2019 Jan 9. Epub 2019 Jan 9.

Dmitry Rogachev National Medical and Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.

Introduction: Translocations involving the KMT2A gene (also known as MLL) are frequently diagnosed in pediatric acute leukemia cases with either lymphoblastic or myeloid origin. KMT2A is translocated to multiple partner genes, including MLLT10/AF10 localizing at chromosomal band 10p12. KMT2A-MLLT10 is one of the common chimeric genes diagnosed in acute leukemia with KMT2A rearrangement (8%), especially in acute myeloid leukemia (AML; 18%). Read More

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http://dx.doi.org/10.1111/ijlh.12969DOI Listing
January 2019
8 Reads

Lnc-SOX6-1 upregulation correlates with poor risk stratification and worse treatment outcomes, and promotes cell proliferation while inhibits apoptosis in pediatric acute myeloid leukemia.

Int J Lab Hematol 2019 Jan 9. Epub 2019 Jan 9.

Department of Hematology and Oncology, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

Introduction: To investigate the correlation of long noncoding RNA-SOX6-1 (lnc-SOX6-1) with clinicopathological features and treatment outcomes in pediatric acute myeloid leukemia (AML) patients, and further explore its function in AML cell proliferation and apoptosis.

Methods: A total of 146 de novo pediatric AML patients and 73 nonhematologic malignancy patients/donors were recruited. Bone marrow samples were obtained, followed by measurement of lnc-SOX6-1 expression by qPCR. Read More

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http://dx.doi.org/10.1111/ijlh.12952DOI Listing
January 2019
2 Reads

Development of new methodologies for the chromogenic estimation of betrixaban concentrations in plasma.

Int J Lab Hematol 2019 Jan 3. Epub 2019 Jan 3.

Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium.

Introduction: Chromogenic anti-Xa assays are the most appropriate tests to estimate the amount of betrixaban in plasma but the sensitivity of available tests is limited and improvements are needed to encompass the on-therapy range.

Methods: Betrixaban was spiked at concentrations ranging from 0 to 500 ng/mL in plasma from healthy donors. Three commercial tests were used (Biophen DiXaI , STA Liquid Anti-Xa, and HemosIL Liquid Anti-Xa), and adaptation of their sample dilution scheme was performed. Read More

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http://dx.doi.org/10.1111/ijlh.12963DOI Listing
January 2019

A CBC algorithm combined with immature platelet fraction is able to identify JAK2 V617F mutation-positive polycythaemia vera patients.

Int J Lab Hematol 2019 Jan 2. Epub 2019 Jan 2.

Haematology Laboratory, Medlab Central, Palmerston North Hospital, Palmerston North, New Zealand.

Introduction: The recent lowering of the World Health Organisation (WHO) haemoglobin (Hb) and haematocrit (HCT) thresholds for diagnosis of polycythaemia vera (PV) has markedly increased the proportion of complete blood counts (CBC) that could be referred for haematologist review for comment, including advice on JAK2 V617F mutation analysis. The utility of an algorithm based on CBC indices and immature platelet fraction (IPF) to select cases for haematologist review was investigated.

Methods: IPF analysis was performed on 22 patients with known JAK2 V617F mutation and 41 patients who were negative for this mutation previously tested because of suspicion of PV. Read More

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http://dx.doi.org/10.1111/ijlh.12967DOI Listing
January 2019
4 Reads

Differentiation of homozygous hemoglobin E and hemoglobin E-β -thalassemia in children.

Int J Lab Hematol 2018 Dec 24. Epub 2018 Dec 24.

Center for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.

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http://doi.wiley.com/10.1111/ijlh.12962
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http://dx.doi.org/10.1111/ijlh.12962DOI Listing
December 2018
2 Reads

Identification of a novel hemoglobin variant Hb Jilin [α139(HC1)Lys>Gln; HBA2:C.418 A>C] in a Chinese family.

Int J Lab Hematol 2018 Dec 22. Epub 2018 Dec 22.

Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, China.

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http://doi.wiley.com/10.1111/ijlh.12964
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http://dx.doi.org/10.1111/ijlh.12964DOI Listing
December 2018
7 Reads
1.870 Impact Factor

Analytical performance of the new D-dimer and antithrombin assay on Roche cobas t 711 analyzer.

Int J Lab Hematol 2018 Dec 18. Epub 2018 Dec 18.

Department of Haematology, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital, Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1111/ijlh.12957DOI Listing
December 2018

Peripheral blood lymphoagglutination and platelet satellitism in marginal zone lymphomas.

Int J Lab Hematol 2018 Dec 18. Epub 2018 Dec 18.

Hospices Civils de Lyon, Lyon, Rhône-Alpes, France.

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http://dx.doi.org/10.1111/ijlh.12956DOI Listing
December 2018

Clotting and chromogenic factor VIII assay variability in post-infusion and spiked samples containing full-length recombinant FVIII or recombinant factor VIII Fc fusion protein (rFVIIIFc).

Int J Lab Hematol 2018 Dec 17. Epub 2018 Dec 17.

UK NEQAS Blood Coagulation, Sheffield, UK.

Introduction: Variability in FVIII measurement is a recognized problem. There are limited data for samples containing recombinant Factor VIII Fc fusion protein (rFVIIIFc). Many studies use samples for which factor concentrate has been spiked into FVIII deficient plasma in vitro. Read More

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http://dx.doi.org/10.1111/ijlh.12940DOI Listing
December 2018
1 Read

Eosin-5'-maleimide binding test-Do we use appropriate reference values to detect hereditary spherocytosis in neonates?

Int J Lab Hematol 2018 Dec 10. Epub 2018 Dec 10.

Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland.

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http://dx.doi.org/10.1111/ijlh.12958DOI Listing
December 2018
4 Reads

Evaluation of next-generation sequencing-based clonality analysis of T-cell receptor gamma gene rearrangements based on a new interpretation algorithm.

Int J Lab Hematol 2018 Dec 8. Epub 2018 Dec 8.

Department of Laboratory Medicine, AZ Sint-Jan Brugge-Oostende, Bruges, Belgium.

Introduction: T-cell receptor gene (TRG) rearrangement profiling is an essential component of the workup at diagnosis of T-cell malignancies. TRG amplification by polymerase chain reaction (PCR) and analysis by capillary electrophoresis (PCR-CE) is mostly widely used but is hampered by a subjective interpretation of its results and possible false-positive interpretation of clonality. Several studies evaluated the advantage of TRG rearrangement analysis by Next Generation Sequencing (TRG-NGS), however few have proposed an adequate data interpretation algorithm. Read More

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http://dx.doi.org/10.1111/ijlh.12954DOI Listing
December 2018
4 Reads

Measurement of extended half-life recombinant factor IX products in clinical practice.

Int J Lab Hematol 2018 Dec 7. Epub 2018 Dec 7.

Department Of Coagulation, Royal Hallamshire Hospital, Sheffield, UK.

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http://dx.doi.org/10.1111/ijlh.12953DOI Listing
December 2018
7 Reads

Genetic variants of erythropoietin (EPO) and EPO receptor genes in familial erythrocytosis.

Int J Lab Hematol 2018 Dec 3. Epub 2018 Dec 3.

Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.

Objectives: Erythrocytosis is characterized by the expansion of erythrocyte compartment including elevated red blood cell number, hematocrit, and hemoglobin content. Familial erythrocytosis (FE) is a congenital disorder with different genetic background. Type 1 FE is primary FE caused by mutation in erythropoietin receptor gene (EPOR). Read More

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http://dx.doi.org/10.1111/ijlh.12949DOI Listing
December 2018
2 Reads

Gaucher disease screening at a general adult hematology tertiary care centre: A prospective study.

Int J Lab Hematol 2018 Dec 4. Epub 2018 Dec 4.

Division of Hematology, Department of Medicine, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.1111/ijlh.12960DOI Listing
December 2018

How I investigate Eosinophilia.

Int J Lab Hematol 2018 Nov 30. Epub 2018 Nov 30.

Medical College of Georgia, Augusta University, Augusta, Georgia.

Eosinophilia is typically secondary, that is, reactive, in nature and is associated with a wide variety of neoplastic and non-neoplastic disorders. Clonal eosinophilia is also seen in a wide variety of hematopoietic neoplasms, and sub-classification can be diagnostically challenging. A proper evaluation of persistent eosinophilia involves correlation of clinical history, laboratory data, cellular morphology, and ancillary testing. Read More

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http://dx.doi.org/10.1111/ijlh.12955DOI Listing
November 2018
1 Read

The phenotypic and molecular diversity of hemoglobinopathies in India: A review of 15 years at a referral center.

Int J Lab Hematol 2018 Nov 29. Epub 2018 Nov 29.

National Institute of Immunohaematology, Mumbai, India.

Introduction: The hemoglobinopathies pose a significant health burden in India. Apart from the β thalassemias and sickle cell disorders, α thalassemias and structural hemoglobin variants are also common. Here we have reviewed the phenotypic and molecular diversity of hemoglobinopathies encountered at a referral center in western India over a period of 15 years. Read More

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http://dx.doi.org/10.1111/ijlh.12948DOI Listing
November 2018
3 Reads

Platelet miR-28 expression level and thrombocytosis in MPN patients.

Int J Lab Hematol 2018 Nov 27. Epub 2018 Nov 27.

Department of Health, Krasnoyarsk Branch of the "National Research Center for Hematology", Krasnoyarsk, Russian Federation.

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http://dx.doi.org/10.1111/ijlh.12951DOI Listing
November 2018

Flow cytometry identification of nonhemopoietic neoplasms during routine immunophenotyping.

Int J Lab Hematol 2018 Nov 27. Epub 2018 Nov 27.

Pathology Division, Citta' della Salute e della Scienza Hospital, Turin, Italy.

Introduction: Nonhemopoietic neoplasms (NHNs) may be encountered during routine flow cytometry (FC) immunophenotyping. The clue of their presence mainly relies on detection of CD45-negative (CD45-) cells with altered scatter parameters.

Methods: In this study, we evaluated a monoclonal antibody combination conceived to characterize the CD45- population by FC, suspected of belonging to NHNs, when present. Read More

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http://dx.doi.org/10.1111/ijlh.12946DOI Listing
November 2018
1 Read

Utility of peripheral blood smear in rapid diagnosis of Pertussis.

Int J Lab Hematol 2018 Nov 27. Epub 2018 Nov 27.

A.O.R.N. "G. Rummo" Benevento, U.O. Patologia Clinica, Benevento, Italy.

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http://dx.doi.org/10.1111/ijlh.12947DOI Listing
November 2018

Influence of DOAC Stop on coagulation assays in samples from patients on rivaroxaban or apixaban.

Int J Lab Hematol 2018 Nov 23. Epub 2018 Nov 23.

Haematology Laboratory, Barts Health NHS Trust, The Royal London Hospital, London, UK.

Introduction: Direct oral anticoagulants (DOACs) require no laboratory monitoring, but they interfere with almost all clotting tests to a varying degree, depending on the DOAC, assay principles and reagents used. DOAC Stop (Haematex Research, Sydney, Australia) has recently been shown to adsorb DOACs from spiked and patient plasmas. The aim of our work was to investigate the DOAC Stop effect on a range of haemostasis assays on plasmas collected from patients on rivaroxaban or apixaban, to see whether it removes the effect of these drugs to enable more accurate interpretation of coagulation assays. Read More

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http://dx.doi.org/10.1111/ijlh.12950DOI Listing
November 2018
54 Reads
1.870 Impact Factor

Quantitative detection of IKZF1 deletion by digital PCR in patients with acute lymphoblastic leukemia.

Int J Lab Hematol 2018 Nov 20. Epub 2018 Nov 20.

Department of Hematology, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.1111/ijlh.12945DOI Listing
November 2018
1 Read

A level-headed approach to measuring direct oral anticoagulants: A 2-year retrospective analysis of DOAC levels from a tertiary UK centre.

Int J Lab Hematol 2018 Nov 8. Epub 2018 Nov 8.

Department of Haematology, Manchester Royal Infirmary, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

Introduction: Direct oral anticoagulants (DOAC) are commonly prescribed and measuring drug levels may be useful in a number of contexts. However, data on DOAC level measurement and their clinical utility in real-world studies are limited.

Methods: We carried out a 2-year retrospective cohort study of DOAC levels measured at our institution. Read More

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http://doi.wiley.com/10.1111/ijlh.12944
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http://dx.doi.org/10.1111/ijlh.12944DOI Listing
November 2018
9 Reads

ETP-ALL with aberrant B marker expression: Case series and a brief review of literature.

Int J Lab Hematol 2018 Nov 8. Epub 2018 Nov 8.

Department of Medical Oncology, Dr BRA IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

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http://dx.doi.org/10.1111/ijlh.12942DOI Listing
November 2018
2 Reads
1.870 Impact Factor

Apoptosis: A biomarker of high-risk phenotype in pediatric acute myeloid leukemia?

Int J Lab Hematol 2019 Feb 1;41(1):141-147. Epub 2018 Nov 1.

Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Dysregulation of apoptosis has been explored in acute myeloid leukemia (AML); yet, its correlation with clinical outcomes in pediatric AML is unknown. This study was aimed to analyze percentage of apoptosis and apoptosis mediated through the intrinsic pathway with clinical outcomes in patients with pediatric AML.

Methods: This prospective study included pediatric AML patients enrolled from July 2013 to August 2016. Read More

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http://doi.wiley.com/10.1111/ijlh.12939
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http://dx.doi.org/10.1111/ijlh.12939DOI Listing
February 2019
18 Reads

Evaluating the performance of automated UV enzymatic assay for screening of glucose 6-phosphate dehydrogenase deficiency.

Int J Lab Hematol 2018 Nov 1. Epub 2018 Nov 1.

Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Introduction: A precise and reliable screening assay for glucose 6-phosphate dehydrogenase (G6PD) deficiency would greatly help avoiding unwanted outcomes due to bilirubin neurotoxicity in neonatal jaundice and antimalarial-induced haemolytic anaemia in malaria patients. Currently, available assays are laborious and require sophisticated laboratory expertise. This study aimed to evaluate the performance of a recently introduced automated screening assay for G6PD deficiency by comparing with a routine spectrophotometric assay. Read More

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http://dx.doi.org/10.1111/ijlh.12943DOI Listing
November 2018
8 Reads

Development of a multiplex assay to detect TERC and TERT mutations associated with immunosuppression therapy failure in Aplastic Anaemia patients.

Int J Lab Hematol 2018 Oct 27. Epub 2018 Oct 27.

Division of Haematology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

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http://doi.wiley.com/10.1111/ijlh.12938
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http://dx.doi.org/10.1111/ijlh.12938DOI Listing
October 2018
3 Reads

A comparison of global coagulation assays between normal controls and patients with thrombocytopenia.

Int J Lab Hematol 2018 Oct 26. Epub 2018 Oct 26.

Department of Haematology, Northern Hospital, Epping, Victoria, Australia.

Introduction: Some patients with thrombocytopenia may be at risk of bleeding although quantitative platelet count is not always a sufficient predictive factor. Global coagulation assays such as thromboelastography (TEG ), calibrated automated thrombogram (CAT) and overall haemostatic potential (OHP) may provide a better assessment of an individual's haemostatic profile.

Methods: Blood samples were collected from thrombocytopenic patients. Read More

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http://doi.wiley.com/10.1111/ijlh.12941
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http://dx.doi.org/10.1111/ijlh.12941DOI Listing
October 2018
18 Reads

Comparison of light transmission aggregometry and multiple electrode aggregometry for the evaluation of patients with mucocutaneous bleeding.

Int J Lab Hematol 2019 Feb 25;41(1):133-140. Epub 2018 Oct 25.

Research Institute in Oncology and Hematology, CancerCare Manitoba, Winnipeg, Manitoba, Canada.

Introduction: The "gold standard" diagnostic test for assessing in vitro platelet function, light transmission aggregometry (LTA), has limitations to application because of sample requirements. Whole blood or multiple electrode aggregometry (MEA) using the Multiplate analyzer (Roche Diagnostics) requires smaller blood volumes and less sample manipulation than LTA, making it an attractive clinical testing option. Direct comparisons of MEA with LTA for diagnosis of platelet aggregation abnormalities are few. Read More

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http://doi.wiley.com/10.1111/ijlh.12937
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http://dx.doi.org/10.1111/ijlh.12937DOI Listing
February 2019
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The diagnostic use of ADVIA 2120i Siemens and an "APL criteria" can help to reduce the rate of early death in the APL.

Int J Lab Hematol 2019 Feb 24;41(1):124-132. Epub 2018 Oct 24.

Department of Laboratory Medicine, Civitanova Marche, Italy.

Introduction: Acute promyelocytic leukemia (APL) is a type of acute myeloid leukemia (AML) with a life-threatening coagulopathy. Once it is suspected, ATRA should be started. Appreciation of APL details is critical, but an experienced hematopathologist may not be available. Read More

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http://doi.wiley.com/10.1111/ijlh.12935
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http://dx.doi.org/10.1111/ijlh.12935DOI Listing
February 2019
13 Reads