3,685 results match your criteria International Journal of Infectious Diseases[Journal]


Treatment efficacy of drug-resistant tuberculosis in Bashkortostan, Russia: a retrospective cohort study.

Int J Infect Dis 2019 Feb 19. Epub 2019 Feb 19.

Institute of Genomics, University of Tartu, Tartu, Riia, 23b, Estonia. Electronic address:

Background: Russia, together with other former Soviet Union countries, is characterized by one of the highest burdens of drug-resistant tuberculosis. Published data on the drug-resistant tuberculosis for these countries are limited, and it is not clear whether current treatment regimens remain effective against constantly evolving drug-resistant strains.

Objectives: The aim of the study was to evaluate treatment efficacy of patients with multidrug-resistant (MDR), extensively drug-resistant (XDR) and drug-susceptible (DSTB) tuberculosis in the most populous region of Russia (Bashkortostan) that borders with Central Asia. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.010DOI Listing
February 2019

Global Infection Prevention Gaps, Needs, and Utilization of Educational Resources: A Cross-Sectional Assessment by the International Society for Infectious Diseases.

Int J Infect Dis 2019 Feb 19. Epub 2019 Feb 19.

International Society for Infectious Diseases, Brookline, Massachusetts, United States; Virginia Commonwealth University, Division of Infectious Diseases, Richmond, Virginia, United States.

Objective: The Guide to Infection Control in the Hospital (Guide) is an open access resource produced by the International Society for Infectious Diseases (ISID) to assist in the prevention of infection acquisition and transmission worldwide. A survey was distributed to 8,055 current Guide users to understand their needs.

Methods: The survey consisted of 48-questions regarding infection prevention and control (IPC) availability and needs. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.017DOI Listing
February 2019

Multicenter clinical experience of real life Dalbavancin use in gram-positive infections.

Int J Infect Dis 2019 Feb 19. Epub 2019 Feb 19.

Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Austria. Electronic address:

Dalbavancin, a lipoglycopeptide with prolonged half-life approved for the treatment of acute bacterial skin-and-soft-tissue-infections, can be used for the treatment of infections caused by gram-positive bacteria requiring long term treatment such as endocarditis, prosthetic joint infections (PJI) or osteomyelitis. Clinical data is limited in these settings.

Objectives: To evaluate indications, safety, tolerability and long-term outcomes of dalbavancin-treated patients. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.013DOI Listing
February 2019

Post Option B+ implementation programme in Nigeria: Determinants of adherence of antiretroviral therapy among pregnant women with HIV.

Int J Infect Dis 2019 Feb 18. Epub 2019 Feb 18.

Department of Nursing, School of Health Sciences, The University of Melbourne, Melbourne, Australia.

Objective: Nigeria has the highest rate of mother to child transmission of HIV (MTCT) in the world. By 2015, all Global Plan priority countries, except Nigeria, had adopted the Option B+ programme.Nigeria finally adopted Option B+ in 2016 with full implementation reported in 2017. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.014DOI Listing
February 2019

Severe post-kala-azar dermal leishmaniasis successfully treated with miltefosine in an Ethiopian HIV patient.

Int J Infect Dis 2019 Feb 18. Epub 2019 Feb 18.

Médecins Sans Frontières - Holland, Naritaweg 10, 1043 BX Amsterdam, The Netherlands. Electronic address:

Post-kala-azar dermal leishmaniasis (PKDL) is a neglected tropical disease characterized by a dermatosis which often appears after successful treatment of visceral leishmaniasis caused by Leishmania donovani. PKDL treatment options are few and have severe limitations. In East- Africa, the standard treatment of PKDL is with daily painful potentially toxic sodium stibogluconate injections, administered for a prolonged duration of 30-60 days. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.012DOI Listing
February 2019

The changing treatment landscape for MDR/XDR-TB - can current clinical trials revolutionise and inform a brave new world?

Int J Infect Dis 2019 Feb 15. Epub 2019 Feb 15.

Centre for Clinical Microbiology, Division of Infection and Immunity, University College London, Royal Free Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ijid.2019.02.006DOI Listing
February 2019

Access to second-line drug susceptibility testing results among patients with Rifampicin resistant tuberculosis after introduction of the Hain Line Probe Assay in Southern provinces, Zimbabwe.

Int J Infect Dis 2019 Feb 15. Epub 2019 Feb 15.

International Union Against Tuberculosis and Lung Disease (The Union), Paris, France; London School of Hygiene and Tropical Medicine, London, UK.

Objectives: To determine the proportion of rifampicin-resistant tuberculosis (RR-TB) patients who accessed second-line drug susceptibility testing (SL-DST) results following introduction of the Hain technology in southern provinces, Zimbabwe.

Design: Cohort study using secondary data.

Results: Xpert MTB/RIF results were used to identify 133 RR-TB patients for this study. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.007DOI Listing
February 2019

Strengthening laboratory surveillance of viral pathogens: Experiences and lessons learned building next-generation sequencing capacity in Ghana.

Int J Infect Dis 2019 Feb 15. Epub 2019 Feb 15.

Division of Viral Diseases, CDC, Atlanta, Georgia, 30329, USA.

Objectives: To demonstrate the feasibility of applying next-generation sequencing (NGS) in medium-resource reference laboratories in Africa to enhance global disease surveillance.

Methods: A training program was developed to support implementation of NGS at Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana. The program was divided into two training stages, first at the Centers for Disease Control and Prevention (CDC) in Atlanta, GA, followed by on-site training at NMIMR for a larger cohort of scientists. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.008DOI Listing
February 2019

Clinical Risk Factors Associated with Multidrug-Resistant Tuberculosis (MDR-TB) in Mali.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

University Clinical Research Center (UCRC)- SEREFO Laboratory, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali. Electronic address:

Background: MDR-TB is a major threat to global TB control. In 2015, 580,000 were treated for MDR-TB worldwide. The worldwide roll-out of GeneXpert MTB/RIF has improved diagnosis of MDR-TB; however, in many countries laboratories are unable to assess drug resistance and clinical predictors of MDR-TB could help target suspected patients. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.004DOI Listing
February 2019

Antibiotic Penetration into Bone and Joints: An Updated Review.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.

Treatment of bone and joint infections can be challenging as antibiotics should penetrate through the rigid bone structure and into the synovial space. Several pharmacokinetic studies measured the extent of penetration of different antibiotics into bone and joint tissues. This review discusses the results of these studies and compares them with minimum inhibitory concentrations (MIC) of common pathogens implicated in bone and joint infections in order to determine which antibiotics may have a greater potential in the treatment of such infections. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.005DOI Listing
February 2019

Acute Respiratory Illness in Rural Haiti.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA; Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL. USA.

Objectives: Acute Respiratory Infection (ARI) is the most common cause of childhood morbidity and mortality in developing countries, including Haiti. Our objective was to detect pathogens found in children with ARI in rural Haiti to help develop evidence-based guidelines for treatment and prevention.

Methods: Retrospective study of students with ARI at four schools in rural Haiti. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.003DOI Listing
February 2019
1 Read

Candida Tropicalis Renal Microabscesses in a Child with Leukemia Confirmed Using Nucleic Acid Amplification and Recovery after Prolonged Antifungal and Corticosteroid Treatment.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

We report the first case of microabscesses detected by polymerase chain reaction (PCR) amplification of nucleic acid from ultrasound-guided aspirated fluid in a three-year old boy with acute lymphoblastic leukemia and febrile neutropenia during induction chemotherapy. Fever persisted despite effective antifungal treatment. The addition of corticosteroid therapy successfully controlled the suspected immune reconstitution inflammatory syndrome (IRIS). Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.002DOI Listing
February 2019
1 Read

Molecular diagnosis and enrichment culture identified a septic pseudoarthrosis due to an infection with Erysipelatoclostridium ramosum.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Institute of Microbiology, Lausanne University Hospital and Lausanne University, Switzerland. Electronic address:

We describe here a rare case of septic pseudarthrosis due to Erysipelatoclostridium ramosum in a female young patient. The patient, currently in remission from Ewing's sarcoma treated by a bone resection and allograft combined with chemotherapy, suffered from a chronic femoral pseudarthrosis in a context of bone insufficiency and graft resorption. A broad range 16S PCR followed by sequencing, as well as an enrichment culture of a bone biopsy revealed the presence of E. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.001DOI Listing
February 2019

Postmortem evidence of disseminated Zika virus infection in an adult patient.

Int J Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore.

Zika virus infections in immunocompetent adults typically are asymptomatic or cause mild symptoms, but have also been associated with neurological complications including Guillain-Barre Syndrome. Zika virusassociated non-neurological fatalities in adults are rare. Herein, we describe a decedent with multiple commodities who developed an acute febrile illness with rash days prior to death. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.047DOI Listing
February 2019
2 Reads
2.330 Impact Factor

Introduction of NDM-1 and OXA-370 from Brazil into Chile in strains of Klebsiella pneumoniae isolated from a single patient.

Int J Infect Dis 2019 Feb 7. Epub 2019 Feb 7.

Laboratorio de Investigación en Agentes Antibacterianos, Universidad de Concepción, Departamento de Microbiología, Facultad de Ciencias Biológicas, Concepción Chile. Electronic address:

Carbapenemase-producing Enterobacteriaceae have rapidly disseminated worldwide and can colonize patients in healthcare centers. As in Chile the first isolations of NDM-1 and OXA-370 carbapenemases were related with a patient arriving from Brazil, the genetic relatedness of Klebsiella pneumoniae strains producers of these enzymes and isolated in both countries was assessed. PFGE analyses revealed that the isolates were clonally related, illustrating how travel contributes to the spread of multidrug-resistant microorganisms. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.051DOI Listing
February 2019
2.330 Impact Factor

Assessment of the Xpert MTB/RIF Ultra assay on rapid diagnosis of extrapulmonary tuberculosis.

Int J Infect Dis 2019 Feb 7. Epub 2019 Feb 7.

Clinic and Research Center of Tuberculosis, Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Objective: To evaluate the diagnostic performance of Xpert MTB/RIF Ultra for EPTB (Extrapulmonary Tuberculosis) patients on different types of extrapulmonary specimens from different anatomic sites.

Methods: Patients with suspected EPTB were prospectively included, extrapulmonary specimens were collected and subjected to culture, Xpert and Xpert Ultra assays in accordance with relevant guidelines.

Results: A total of 225 cases were included which contained 200 EPTB cases (43 culture-positive EPTB, 157 culture-negative EPTB which were diagnosed based on pathological results and a satisfied response to anti-TB treatment) and 25 non-EPTB cases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193006
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http://dx.doi.org/10.1016/j.ijid.2019.01.050DOI Listing
February 2019
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Latent Tuberculosis Infection and renal transplantation - diagnosis and management.

Int J Infect Dis 2019 Feb 6. Epub 2019 Feb 6.

Division of Infection and Immunity, Center for Clinical Microbiology, University College London and the National Institute of Health Research Biomedical Research Centre at University College London Hospitals NHS Foundation Trust, London, UK. Electronic address:

Background: Tuberculosis (TB) continues to be the commonest infectious disease cause of death worldwide. Tuberculosis is an important infectious disease cause of morbidity and death in renal transplant recipients. Tuberculosis can also cause loss of kidney allograft OBJECTIVES: The purpose of this viewpoint is to highlight the issues related to prevention, diagnosis and treatment of tuberculosis in renal transplant recipients. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.049DOI Listing
February 2019
6 Reads

Tuberculin Skin Test - outdated or still useful for Latent TB Infection screening?

Int J Infect Dis 2019 Feb 6. Epub 2019 Feb 6.

National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, Rome, Italy. Electronic address:

Objective: To make an informed viewpoint on the usefulness of Tuberculin Skin test (TST) compared to Interferon Gamma Release Assays (IGRAs) for diagnosis of Latent TB Infection (LTBI) in different geographical settings.

Methods: We reviewed the current literature on TST compared to IGRA, including national implementation of WHO LTBI recommendations and retrospective data over the past 7 years at the National Institute for Infectious Diseases "L. Spallanzani" as indirect indicator of usage of both tests under actual programmatic conditions. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.048DOI Listing
February 2019

Granulomatous hepatitis by Nocardia species - An unusual case.

Int J Infect Dis 2019 Feb 4. Epub 2019 Feb 4.

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

We wish to report a case of granulomatous hepatitis due to Nocardia. A 63year old immunocompetent patient presented with persistent fever, weight loss and malaise. Radiology suggested enlarged liver with dense diffuse to multiple tiny micronodular areas of parenchymal involvement, possibly granulomatous. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.046DOI Listing
February 2019

High prevalence of epilepsy in an onchocerciasis endemic health zone in the Democratic Republic of the Congo, despite 14 years of community-directed treatment with ivermectin: A mixed-method assessment.

Int J Infect Dis 2019 Feb;79:187-194

Global Health Institute, University of Antwerp, Antwerp, Belgium. Electronic address:

Objectives: To investigate the reasons for the high prevalence of epilepsy (>6%) discovered in 2015 in the Aketi health zone in the north of the Democratic Republic of the Congo.

Methods: Persons with epilepsy (PWE) diagnosed in a door-to-door survey in 2015 were traced and re-examined in 2017 by a neurologist. Confirmed PWE were paired with matched controls. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353816PMC
February 2019

Onchocerciasis associated epilepsy-A question of causality.

Int J Infect Dis 2019 Feb;79:185-186

Division of High-Consequence Pathogens and Pathology, Division of Vector-Borne Diseases, US Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA.

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http://dx.doi.org/10.1016/j.ijid.2019.01.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361767PMC
February 2019

Improved early diagnosis of difficult cases of tuberculous pleural effusion by combination of throracoscopy with immunological tests.

Int J Infect Dis 2019 Jan 30. Epub 2019 Jan 30.

Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Introduction: Although pleural effusion is a common clinical manifestation, differential diagnosis of the cause of pleural effusion is often challenging, especially in early distinguishing tuberculous pleurisy (TP) from other pleural effusion. This study is aimed at evaluating the values of commonly used laboratory tests for early diagnosis of difficult cases of pleural effusion.

Methods: Patients with undiagnosed pleural effusion were enrolled and subjected to 5 laboratory tests including thoracoscopy, pleural fluid adenosine deaminase assay (ADA), serum tuberculosis antibody test (TB-antibody), tuberculin skin test (TST), and T-SPOT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193005
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http://dx.doi.org/10.1016/j.ijid.2019.01.045DOI Listing
January 2019
3 Reads

First case of Aspergillus caelatus airway colonization in a Chronic Obstructive Pulmonary Disease patient.

Int J Infect Dis 2019 Jan 25. Epub 2019 Jan 25.

Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique universités, EA1155-IICiMed, Nantes, France; Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia; Clínica Universitaria Colombia, Bogotá, Colombia.

Background: During a cross-sectional study on allergic aspergillosis in Chronic Obstructive Pulmonary Disease patients in Bogotá, Colombia, we reported the case of a 65-year-female patient with GOLD 2011 D classification, presenting dyspnea at the time of visit and aspergillus in repeated sputum cultures.

Methods: The isolate was identified at the section level based on macroscopic and microscopic characteristics and gene sequencing was used for precise molecular identification. Antifungal sensibility was determined by Sensititre YeastOne™ while virulence was assessed using Galleria mellonella larvae model. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.043DOI Listing
January 2019
2 Reads

Hemorrhagic shock resulting from varicella zoster gastritis in a non-immunocompromised patient.

Int J Infect Dis 2019 Jan 25. Epub 2019 Jan 25.

Service de Réanimation Médicale, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France; Groupe de Recherche Clinique CARMAS, Université Paris-Est Créteil, IMRB, Créteil, France.

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http://dx.doi.org/10.1016/j.ijid.2019.01.042DOI Listing
January 2019
1 Read
2.330 Impact Factor

Macrolides in Critically Ill Patients with Middle East Respiratory Syndrome.

Int J Infect Dis 2019 Jan 25. Epub 2019 Jan 25.

International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia. Electronic address:

Objectives: Macrolides have been reported to be associated with improved outcomes in patients with viral pneumonia related to influenza and other viruses, possibly because of their immune-modulatory effects. Macrolides have frequently been used in patients with Middle East Respiratory Syndrome (MERS). This study investigated the association of macrolides with 90-day mortality and MERS coronavirus (CoV) RNA clearance in critically ill patients with MERS. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.041DOI Listing
January 2019
4 Reads
2.330 Impact Factor

Challenging MDR-TB clinical problems- the case for a new Global TB Consilium supporting the compassionate use of new anti-TB drugs.

Int J Infect Dis 2019 Jan 25. Epub 2019 Jan 25.

Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy. Electronic address:

MDR-TB is a growing challenge worldwide, and an obstacle to TB elimination. It is apparent that TB is being replaced by small but growing number of resistant cases with an anticipated 2 million cases of MDR-TB within the next two decades. One of the potential causes of MDR-TB is iatrogenic and we risk losing our new drugs through inexperience and repetition of basic errors of adding single active drugs to failing regimens. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193005
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http://dx.doi.org/10.1016/j.ijid.2019.01.040DOI Listing
January 2019
1 Read
2.330 Impact Factor

A Multiplex PCR assay for Detection of Vibrio vulnificus, Aeromonas hydrophila, Methicillin-resistant Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus agalactiae from the Isolates of Patients with Necrotizing Fasciitis.

Int J Infect Dis 2019 Jan 25. Epub 2019 Jan 25.

Department of Orthopaedic Surgery, Chang Gung Memorial Hospital at Chia-Yi, Taiwan, Republic of China; College of Medicine, Chang Gung University at Taoyuan, Taiwan.

Background: Vibrio vulnificus, Aeromonas hydrophila, methicillin-resistent Staphylococcus aureus (MRSA), Group A Streptococcus, and Group B Streptococcus, are commonly detected causative agents of necrotizing fasciitis (NF) in our institution. This study aimed to develop and evaluate a multiplex PCR method for the simultaneous detection of five of the most important human pathogens involved in NF by using a novel combination of species-specific genes.

Methods: Samples used here were collected from 99 patients with surgically confirmed necrotizing fasciitis of the extremities that were consecurtively hospitalized between June 2015 and November 2017. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.037DOI Listing
January 2019
1 Read

Pathogens in Patients with Granulomatous lobular mastitis.

Int J Infect Dis 2019 Jan 24. Epub 2019 Jan 24.

Department of Pathology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China. Electronic address:

Objective: Granulomatous lobular mastitis (GLM) is a rare inflammatory disease of breast that clinically mimicks breast cancer. However, its etiology is not completely defined. The purpose of this study was to systematically studyGlM bacteriology using advanced detection technology. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.034DOI Listing
January 2019
9 Reads

NTCP S267F variant associates with decreased susceptibility to HBV and HDV infection and decelerated progression of related liver diseases.

Int J Infect Dis 2019 Jan 24;80:147-152. Epub 2019 Jan 24.

Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; Vietnamese-German Center for Medical Research, Hanoi, Vietnam; Duy Tan University, Da Nang, Vietnam. Electronic address:

Objectives: To determine potential associations of the rs2296651 variant (c.800C>T, S267F) of NTCP with HBV and HBV plus concomitant HDV infection as well as with the progression of related liver diseases.

Methods: The S267F variant was genotyped by DNA sequencing in 620 HBV-infected patients and 214 healthy controls (HCs). Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.038DOI Listing
January 2019
1 Read
2.330 Impact Factor

Improving treatment outcomes for MDR-TB - Novel host-directed therapies and personalised medicine of the future.

Int J Infect Dis 2019 Jan 24. Epub 2019 Jan 24.

Centre for the Unknown, Avenida Brasília, 1400-038 Lisbon, Portugal; Department of Oncology and Haematology, Krankenhaus Nordwest, Frankfurt am Main, Germany. Electronic address:

Multidrug-resistant TB (MDR-TB) is a major threat to global health. In 2017, only 50% of patients with MDR-TB who received WHO-recommended treatment were cured. Most MDR-TB patients who recover continue to suffer from functional disability due to lung damage. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.039DOI Listing
January 2019
2 Reads

Multicenter Evaluation of the Biochip Assay for Rapid Detection of Mycobacterial Isolates in Smear-Positive Specimens.

Int J Infect Dis 2019 Jan 24. Epub 2019 Jan 24.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. Electronic address:

Objectives: The objective of this study was to conduct a multicentre evaluation of the performance of the biochip assay in the rapid identification of mycobacteria in smear-positive sputum specimens.

Methods: A total of 1751 sputum specimens were obtained from 7 cities in Zhejiang, China. All of the specimens were used for the discrimination of Mycobacterium species using the biochip assay, and the results were compared to the golden standard method of culture, hsp65, 16S rRNA and rpoB sequence analysis. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.036DOI Listing
January 2019
2 Reads

Carriage of penicillin non-susceptible pneumococci among children in northern Tanzania in the 13-valent pneumococcal vaccine era.

Int J Infect Dis 2019 Jan 24. Epub 2019 Jan 24.

Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden; Centre for Antibiotic Resistance Research (CARe), University of Gothenburg, Gothenburg, Sweden.

Objectives: To determine antibiotic susceptibility and serotype distribution of colonizing Streptococcus pneumoniae in Tanzanian children, we performed serial cross-sectional surveys following national introduction of the 13-valent pneumococcal conjugate vaccine PCV13 in December 2012.

Methods: 775 children below 2 years of age were recruited and sampled from nasopharynx at primary health centres in Moshi, Tanzania between 2013 and 2015. S. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.035DOI Listing
January 2019
4 Reads

Incidence of dengue illness among children in an urban setting in South India: A population based study.

Int J Infect Dis 2019 Jan 24. Epub 2019 Jan 24.

Department of Community Health, Christian Medical College, Vellore, Tamil Nadu, 632004, India. Electronic address:

Objectives: Our main objective was to estimate population based dengue incidence estimates in children with fever >3 days.

Methods: The study used the 'National Surveillance System for Enteric Fever in India' (NSSEFI) cohort at the Vellore site. Children aged 6 months to 14 years from a peri-urban setting in Vellore were followed up for a year for the presence of fever. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.033DOI Listing
January 2019
2 Reads

Dengue Vaccine Development: Global and Indian Scenarios.

Int J Infect Dis 2019 Jan 23. Epub 2019 Jan 23.

Recombinant Gene Products Group, Molecular Medicine Division, International Centre for Genetic Engineering & Biotechnology, Aruna Asaf Ali Marg, New Delhi, India; Translational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, India. Electronic address:

India is home to nearly a third of the global population at risk of dengue, a viral disease caused by four antigenically and genetically distinct dengue viruses. Clinical illness following dengue virus infection could either be mild and self-limiting dengue fever or severe dengue hemorrhagic fever/dengue shock syndrome, with potentially fatal consequences. A live attenuated vaccine known as Dengvaxia, developed by Sanofi, was licensed in 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193004
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http://dx.doi.org/10.1016/j.ijid.2019.01.029DOI Listing
January 2019
6 Reads

Pertussis surveillance in a children hospital in Bangkok, Thailand.

Int J Infect Dis 2019 Jan 23. Epub 2019 Jan 23.

Queen Sirikit National Institute of Child Health, Bangkok, Thailand.

Objectives: To investigate the incidence, clinical characteristics and cost associated with pertussis in Thai children with persistent cough.

Methods: A prospective study was conducted among children aged 0-18 years with persistent cough for ≥7days with at least one of the followings: paroxysm, inspiratory whooping, or post-tussive emesis. Nasopharyngeal swabs were obtained and tested for pertussis real time polymerase chain reaction (RT-PCR). Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.031DOI Listing
January 2019
1 Read

Understanding the complex seasonality of seasonal influenza A and B viruses transmission: Evidence from 6-year surveillance data in Shanghai, China.

Int J Infect Dis 2019 Jan 23. Epub 2019 Jan 23.

School of Public Health and Social Work, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia. Electronic address:

Objectives: Understanding the complexity of influenza subtype seasonality is critical to promoting a suitable vaccination program. Our study aims to identify and compare the seasonality and epidemiological features of seasonal influenza subtypes after the 2009 A/H1N1 pandemic and to lay a foundation for further investigation into the social and environmental factors affecting seasonal influenza transmission.

Methods: Influenza-like illness (ILI) cases surveillance were conducted in two sentinel hospitals between 2012 and 2018 in Pudong New Area, Shanghai. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.027DOI Listing
January 2019
1 Read

Community acquired Stenotrophomonas maltophilia discitis: Diagnosis aided by shotgun metagenomic sequencing.

Int J Infect Dis 2019 Jan 23;81:1-3. Epub 2019 Jan 23.

Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, China; Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, CA, USA. Electronic address:

We report a rare case of culture negative L4-L5 discitis and epidural abscess in an immunocompetent child who had dry cupping therapy performed to treat low back strain. The causative pathogen was identified as Stenotrophomonas maltophilia by shotgun metagenomic sequencing of spinal cord aspirate after more than one month of unsuccessful empirical treatment with 6 different antibiotics. The patient was successfully treated with Sulfamethoxazole-trimethoprim and minocycline. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193004
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http://dx.doi.org/10.1016/j.ijid.2019.01.032DOI Listing
January 2019
6 Reads

The level of the endoplasmic reticulum stress chaperone protein - Binding Immunoglobulin Protein (BiP) decreases following successful TB treatment.

Int J Infect Dis 2019 Jan 23. Epub 2019 Jan 23.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town, 8000, South Africa. Electronic address:

Increased Mycobacterium tuberculosis (M.tb) burden inside the host leads to higher demand of response proteins. This in turn results in metabolic shift and cellular stress which is caused by accumulation and trafficking of these proteins within the ER. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.030DOI Listing
January 2019
6 Reads

Correlates of non-typhoidal Salmonella bacteraemia: a case-control study.

Int J Infect Dis 2019 Jan 23. Epub 2019 Jan 23.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Objective: Limited up-to-date evidence exists on host-related characteristics of non-typhoidal Salmonella (NTS) bacteraemia in high-income countries. We examined correlates of non-typhoidal Salmonella (NTS) bacteraemia in Israel.

Methods: A case-control study was conducted using medical records of cases hospitalised with NTS bacteraemia (N=106; 57 children 49 adults) in Jerusalem during 1997-2016. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.028DOI Listing
January 2019
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Streptococcus pyogenes infections with limited emm type diversity in the homeless population of Brussels, 2016-2018.

Int J Infect Dis 2019 Jan 23. Epub 2019 Jan 23.

Molecular Bacteriology Laboratory, Université Libre de Bruxelles (ULB), Brussels, Belgium; Queen Fabiola Children University Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium; Murdoch Children's Research Institute, Melbourne, Australia; Centre for International Child Health, University of Melbourne, Melbourne, Australia. Electronic address:

Objectives: Characterize the clinical features, outcome and strain diversity of inpatients hospitalized in our institution with a laboratory-confirmed Streptococcus pyogenes (GAS) infection according to homeless status.

Methods: Between August 2016 and January 2018, all patients hospitalized with a laboratory-confirmed GAS infection were prospectively enrolled along with recording of risk factors. GAS strains were characterized using emm-typing and emm-clustering in both inpatients and outpatients. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.026DOI Listing
January 2019
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Impact evaluation of a Critical Pathway for patients with Clostridium difficile infection: A pre-post analysis in a Third Level Referral Center.

Int J Infect Dis 2019 Jan 22;80:105-110. Epub 2019 Jan 22.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Department of Internal Medicine, Università Cattolica del Sacro Cuore, Roma, Italy.

Background: Clostridium Difficile Infections (CDIs) have been increasing both in incidence and in severity, representing a big public health concern.

Aim: The aim of this study was to evaluate the impact of a recently implemented Critical Pathway (CP) focused on patients with CDI in an Italian Teaching Hospital.

Methods: The CP implementation consisted of intervention aimed to faster diagnosis and appropriateness in admission and discharge point of care; activation of a multidisciplinary team; staff training; information to patients and caregivers. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.025DOI Listing
January 2019
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American Trypanosomiasis and Chagas disease: sexual transmission.

Int J Infect Dis 2019 Jan 18. Epub 2019 Jan 18.

Chagas Disease Multidisciplinary Research Laboratory, Faculty of Medicine, University of Brasília, 70910-900, Federal District, Brazil. Electronic address:

Objective: To contribute to the discussion on the research findings that indicate the American Trypanosomiasis and Chagas disease can be sexually transmitted in humans.

Methods: A review of the literature about the routes of transmission of Trypanosoma cruzi parasites and to evaluate the dispersion of Chagas disease now in five Continents.

Main Finding: The epidemiologic profile of American Trypanosomiasis, yet considered a neglected disease of the poor people of Latin America, changed over time. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.021DOI Listing
January 2019
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Detection of West Nile virus lineage 1 sequences in blood donors, Punjab province, Pakistan.

Int J Infect Dis 2019 Jan 18. Epub 2019 Jan 18.

CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.

Objectives: This study was performed to determine the presence of West Nile virus (WNV) in mosquito specimens and human blood donors from Pakistan.

Methods: 4,500 mosquito specimens were collected using CO-baited traps from five selected districts of Punjab province, Pakistan. Mosquito were taxonomically identified using standard morphological keys resulting in 166 pools. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.020DOI Listing
January 2019
6 Reads
2.330 Impact Factor

Evaluation of serological cross-reactivity between yellow fever and other flaviviruses.

Int J Infect Dis 2019 Jan 17;81:4-5. Epub 2019 Jan 17.

Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil; Hospital das Clinicas HCFMUSP (LIM52), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. Electronic address:

Objectives: This study was performed to determine whether neutralizing antibodies against yellow fever virus (YFV) generated by YFV vaccine could interfere in the specificity of dengue virus (DENV) and Zika virus (ZIKV) IgG ELISA tests.

Methods: Seventy-nine pairs of serum samples (pre- and post-vaccination), collected during the years 1997-1998 from children with no history of yellow fever disease who had been vaccinated against YFV, were tested. The seroconversion post-vaccination was evaluated through plaque reduction neutralization test (PRNT), and four different commercial ELISA kits were used for the detection of DENV and ZIKV IgG antibodies. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.023DOI Listing
January 2019
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Prevalence of Clostridium difficile Infections Among Kenyan Children with Diarrhea.

Int J Infect Dis 2019 Jan 17. Epub 2019 Jan 17.

University of Texas Health Science Center, School of Public Health, Department of Epidemiology, Human Genetics, and Environmental Sciences, Center for Infectious Diseases, Houston, Texas, USA; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Microbiology and Infectious Diseases Program, Houston, Texas, USA. Electronic address:

Background: Diarrhea causes significant morbidity and mortality among children worldwide. Regions most affected by diarrhea are the sub-Saharan African and Southeast Asia, where antibiotics are in common use and can make children more vulnerable to Clostridium difficile and pathogens which are not affected by these drugs. Indeed, Clostridium difficile is a major diarrhea-associated pathogen and poses a significant threat to vulnerable and immunocompromised populations. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.024DOI Listing
January 2019
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Dengue Diagnosis in endemic area of Peru: clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM and IgG.

Int J Infect Dis 2019 Jan 17. Epub 2019 Jan 17.

School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences. Universidad Peruana de Ciencias Aplicadas. Lima, Peru; Laboratorio de Biología Molecular. Instituto de Investigación Nutricional. Lima, Peru. Electronic address:

Background: Huánuco is a central eastern region of Peru in whose geography we can find both high forest and low jungle, as well as the mountain range that constitutes the inter-Andean valleys. It is considered an endemic Dengue region due to the many favorable conditions that facilitate the transmission of the virus.

Methodology: A total of 268 serum samples from patients with acute febrile illness (AFI) were assessed for the presence of Dengue virus (DENV) via RT-PCR, Elisa NS1, IgM and IgG during December 2015 and March 2016 in Huánuco, Peru. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.022DOI Listing
January 2019
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Oral eradication therapy for melioidosis: Important but not without risks.

Int J Infect Dis 2019 Jan 16;80:111-114. Epub 2019 Jan 16.

Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia; Infectious Diseases Department, Royal Darwin Hospital, Australia; Northern Territory Medical Program, Darwin, Australia. Electronic address:

Objectives: The purpose of this study was to quantify the adverse effects from oral eradication therapy for melioidosis, which is usually with high dose trimethoprim-sulfamethoxazole for 3-6 months.

Methods: This retrospective cohort study reviewed side effects from oral eradication therapy in patients presenting with first episode culture-confirmed melioidosis in the tropical north of Australia's Northern Territory between 1st October 2012 and 1st January 2017.

Results: 234 patients presented for the first time with culture-confirmed melioidosis. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.019DOI Listing
January 2019
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A young boy with disseminated Mycobacterium avium complex infection.

Int J Infect Dis 2019 Jan 15;81:10-11. Epub 2019 Jan 15.

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

The case of a Chinese boy with no medical history, who presented with diarrhea and weight loss of 14-month duration and rashes and fever or 6-month duration, is described. The patient was finally diagnosed with disseminated Mycobacterium avium complex infection by skin biopsy and tissue culture. This case shows that Mycobacterium avium complex infection should be considered even in an immunocompetent patient with diarrhea and skin lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193002
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http://dx.doi.org/10.1016/j.ijid.2019.01.016DOI Listing
January 2019
5 Reads

Analysis of dengue specific memory B cells, neutralizing antibodies and binding antibodies in healthy adults from India.

Int J Infect Dis 2019 Jan 15. Epub 2019 Jan 15.

ICGEB-Emory Vaccine Center, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India. Electronic address:

Background: The Indian population is facing highest dengue burden worldwide supporting an urgent need for vaccines. For vaccine introduction, evaluation and interpretation it is important to gain a critical understanding of immune memory induced by natural exposure. However, immune memory to dengue remains poorly characterized in this region. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193002
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http://dx.doi.org/10.1016/j.ijid.2019.01.018DOI Listing
January 2019
7 Reads
2.330 Impact Factor

"Pulmonary Nocardiosis in Western Europe -Clinical evaluation of 43 patients and population-based estimates of hospitalization rates".

Int J Infect Dis 2019 Jan 15. Epub 2019 Jan 15.

Center for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany.

Background: Pulmonary nocardiosis (PN) is an uncommon but potentially life-threatening infection. Most of our knowledge is derived from case reports or smaller case series. Recently, increasing PN incidence rates have been reported. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193000
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http://dx.doi.org/10.1016/j.ijid.2018.12.010DOI Listing
January 2019
6 Reads