1,939 results match your criteria International Journal of Immunopathology and Pharmacology [Journal]


Effect of short peptides on neuronal differentiation of stem cells.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419828613

2 Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg, Russia.

It has been demonstrated that short peptides play an important role in the transmission of biological information, modulation of transcription, and restoring genetically conditioned alterations occurring with age. Peptidergic regulation of homeostasis occupies an important place in physiological processes, which lead to the aging of cells, tissues, and organs, consisting in the involution of major regulatory systems-the nervous, the endocrine, and the immune. The effect of AED (Ala-Glu-Asp), KED (Lys-Glu-Asp), KE (Lys-Glu), AEDG (Ala-Glu-Asp-Gly) peptides and their compound on neuronal differentiation of human periodontal ligament stem cells (hPDLSCs) was studied by immunofluorescence and western blot analysis. Read More

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http://dx.doi.org/10.1177/2058738419828613DOI Listing
February 2019

LncRNA SNHG3 promotes cell growth by sponging miR-196a-5p and indicates the poor survival in osteosarcoma.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418820743

2 Department of Orthopedic Surgery, Shibei Hospital of Jingan District, Shanghai, China.

Abnormal expression of long noncoding RNAs (lncRNAs) is closely associated with the pathogenesis of multiple malignancies, and lncRNA small nucleolar RNA host genes (SNHGs) play critical roles in tumor progression. However, the mechanism by which SNHG3 contributes to osteosarcoma (OS) remains elusive. The association between SNHG3 expression and the clinicopathological characteristics in OS patients was analyzed using the TCGA (The Cancer Genome Atlas) dataset. Read More

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http://dx.doi.org/10.1177/2058738418820743DOI Listing
February 2019

Antifungal activity in the methanolic, aqueous and hexane extracts of Calligonum polygonoides.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418821275

2 Department of Eastern Medicine, Directorate of Medical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.

Calligonum polygonoides is locally called as Phog which belongs to the Polygonaceae family. It is traditionally used as an antifungal. The methanolic extract, hexane extract, ethyl acetate extract and aqueous extract were screened against Candida albicans and Aspergillus niger in seven concentrations, that is, 1. Read More

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http://dx.doi.org/10.1177/2058738418821275DOI Listing
February 2019

Detection of Mycobacterium tuberculosis in AFB smear-negative sputum specimens through MTB culture and GeneXpert MTB/RIF assay.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419827174

1 Department of Allied Health Sciences, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan.

Tuberculosis (TB) is an important public health issue around the globe which is a chronic infectious disease and is still one of the major challenges for developing countries. The emergence of drug-resistant TB makes the condition worse and there is an urgent need of fast, highly sensitive diagnostic methods. This study was undertaken to evaluate the performance of GeneXpert MTB/RIF assay and MTB culture for the detection of Mycobacterium tuberculosis (MTB) in sputum smear-negative pulmonary TB/drug-resistant tuberculosis (DR-TB) suspects. Read More

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http://dx.doi.org/10.1177/2058738419827174DOI Listing
February 2019

Reuterinos as adjuvant for peri-implant treatment: A pilot study.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419827745

5 Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

The objective of this study was to evaluate the effects of lozenges-containing Lactobacillus reuteri as an adjuvant treatment of peri-implant mucositis and to detect the level of L. reuteri colonization in the peri-implant tissues of treated patients. A total of 10 patients were selected. Read More

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http://dx.doi.org/10.1177/2058738419827745DOI Listing
February 2019

Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418820402

1 Department of Biochemistry, University of Otago, Dunedin, New Zealand.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a poorly understood disease affecting 0.2%-2% of the global population. To gain insight into the pathophysiology of ME/CFS in New Zealand, we examined the transcriptomes of peripheral blood mononuclear cells by RNA-seq analysis in a small well-characterized patient group (10 patients), with age/gender-matched healthy controls (10 control subjects). Read More

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http://dx.doi.org/10.1177/2058738418820402DOI Listing
February 2019

Blocking of checkpoint receptor PD-L1 aggravates osteoarthritis in macrophage-dependent manner in the mice model.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418820760

3 Department of Spinal Surgery, The Second Hospital of Shandong University, Jinan, China.

As a chronic degenerative joint disease, osteoarthritis is among the most common diseases all over the world. In osteoarthritis, inflammation plays an important role in the generation of joint symptoms and the development of disease. When the programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint is blocked, the antitumor immunity will be enhanced. Read More

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http://dx.doi.org/10.1177/2058738418820760DOI Listing
February 2019

Possible treatment for cutaneous lichen planus: An in vitro anti-inflammatory role of Angelica polysaccharide in human keratinocytes HaCaT.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418821837

Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Cutaneous lichen planus (CLP) is an autoimmune disease. Angelica polysaccharide (AP) has been found to exert immunomodulation activity. In this study, we explored the roles of AP in lipopolysaccharide (LPS)-induced inflammatory injury of human keratinocytes (HaCaT cells), as well as the underlying mechanisms. Read More

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http://dx.doi.org/10.1177/2058738418821837DOI Listing
February 2019

Effects of 12-months treatment with zoledronate or teriparatide on intima-media thickness of carotid artery in women with postmenopausal osteoporosis: A pilot study.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418822439

1 Endocrinology and Diabetology Service, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Atherosclerosis and osteoporosis are interrelated entities and share similar pathogenic mechanisms. Recent studies showed that key proteins of bone metabolism, such as osteoprotegerin (OPG) and osteopontin (OPN), are also involved in vascular atherosclerosis and calcifications. The carotid intima-media thickness (CA-IMT) is an early quantitative marker of generalized atherosclerosis. Read More

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http://dx.doi.org/10.1177/2058738418822439DOI Listing
February 2019

Tripterine up-regulates miR-223 to alleviate lipopolysaccharide-induced damage in murine chondrogenic ATDC5 cells.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418824521

Department of Orthopedics, Liaocheng Third People's Hospital, Liaocheng, China.

Tripterine, also known as celastrol, is a main natural ingredient in Tripterygium wilfordii. Tripterine has a variety of pharmacological functions, and the therapeutic potential of tripterine in many kinds of inflammation-linked diseases has been revealed. However, the function of tripterine on osteoarthritis still remains unclear. Read More

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http://dx.doi.org/10.1177/2058738418824521DOI Listing
February 2019

Heat stress combined with lipopolysaccharide alter the activity and superficial molecules of peripheral monocytes.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419828891

1 Department of Critical Care Medicine, The Fifth Peoples' Hospital of Dongguan, Dongguan Hospital Affiliated to Jinan University, Dongguan, China.

The purpose of this study was to focus on the underlying relationship between the hyperactivity for the peripheral monocytes and heat stroke by investigating the inflammatory oxidative activity of and the expression of superficial molecules. Peripheral blood samples were collected from 10 healthy adult volunteers. Human blood monocytes were isolated by density gradient centrifugation and sequent adherent culture. Read More

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http://dx.doi.org/10.1177/2058738419828891DOI Listing
February 2019
1 Read

Monomorphic epitheliotropic intestinal T-cell lymphoma may mimic intestinal inflammatory disorders.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419829387

3 Department of Pharmacology, Wuhan University, Wuhan, P.R. China.

There is a significant overlap between intestinal lymphoproliferative disorders (LPDs) and inflammatory conditions of the intestine, including inflammatory bowel disease (IBD), in clinical, endoscopic, or histologic appearance, leading to diagnostic challenges. We report two cases of monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) that were initially considered to be ulcerative colitis (UC) and lymphocytic colitis, respectively. Both patients presented with diarrhea and abdominal pain. Read More

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http://dx.doi.org/10.1177/2058738419829387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376542PMC
February 2019
1 Read

Lp-PLA, a new biomarker of vascular disorders in metabolic diseases.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419827154

1 Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Metabolic diseases are chronic disorders correlated to a greater risk of cardiovascular event and death. Recently, many data have sustained the biological link between microvascular dysfunction, oxidative stress, vascular inflammation, and metabolic diseases. The determination of new and specific blood biomarkers of vascular inflammation associated with obesity-related metabolic syndrome (MetS) and diabetes such as lipoprotein-associated phospholipase A (Lp-PLA) could be useful to identify subject with high risk of cardiovascular events. Read More

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http://dx.doi.org/10.1177/2058738419827154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360470PMC
February 2019

Adipose tissue transplant in recurrent folliculitis decalvans.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418814688

Department of Plastic and Reconstructive Surgery, San Gallicano Dermatological Institute IRCCS, Rome, Italy.

Folliculitis decalvans is a rare clinical disorder classified as primary neutrophilic scarring alopecia with a slight preference for the male gender. Here, we report the use of autologous fat transplantation as a source of stem cell therapy for hair re-growth assisted by inflammatory action of the fat itself in a female patient. The patient underwent adipose transplantation in April and September 2017. Read More

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http://journals.sagepub.com/doi/10.1177/2058738418814688
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http://dx.doi.org/10.1177/2058738418814688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259063PMC
November 2018
14 Reads

Evaluation of antidiabetic activity of Ipomoea batatas L. extract in alloxan-induced diabetic rats.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418814678

4 College of Agriculture, University of Sargodha, Sargodha, Pakistan.

Different allopathic drugs are being used for the treatment of diabetes mellitus but more emphasis are being placed on the use of medicinal plants, herbs, and natural extracts of fruits and vegetables due to their easy availability, easy consummation with low cost, and with no well-reported side effects. White skinned sweet potato (WSSP; Ipomoea batatas L.) peel-off was selected to find out its antidiabetic potential as well as to explore the effects on selected biochemical parameters in diabetes-induced Wistar rats. Read More

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http://dx.doi.org/10.1177/2058738418814678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259064PMC
November 2018
19 Reads

Kaempferol inhibits proliferation, migration, and invasion of liver cancer HepG2 cells by down-regulation of microRNA-21.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418814341

4 Department of General Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.

Liver cancer is one of the most common and lethal cancers in human digestive system, which kills more than half a million people every year worldwide. This study aimed to investigate the effects of kaempferol, a flavonoid compound isolated from vegetables and fruits, on hepatic cancer HepG2 cell proliferation, migration, invasion, and apoptosis, as well as microRNA-21 (miR-21) expression. Cell viability was detected using cell counting kit-8 (CCK-8) assay. Read More

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http://dx.doi.org/10.1177/2058738418814341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259061PMC
November 2018

Triptolide inhibits benign prostatic epithelium viability and migration and induces apoptosis via upregulation of microRNA-218.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418812349

2 Department of Urinary Surgery, Affiliated Hospital of Taishan Medical University, Taian, China.

Benign prostatic hypertrophy (BPH) has become a troublesome disease for elder men. Triptolide (TPL) has been reported to be a potential anticancer agent. However, the potential effects of TPL on BPH have not been shown out. Read More

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http://dx.doi.org/10.1177/2058738418812349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247479PMC
November 2018
1 Read

Alpha defensin, leukocyte esterase, C-reactive protein, and leukocyte count in synovial fluid for pre-operative diagnosis of periprosthetic infection.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418806072

1 Laboratory of Clinical Chemistry and Microbiology, IRCCS Galeazzi Orthopedic Institute, Milan, Italy.

Synovial fluid analysis for diagnosis of prosthetic joint infections has gained increasing interest in the recent past when markers more specific for these infections than the serum ones have been identified. Despite the important steps forward, identification of a gold standard has not yet been identified. In this study, usefulness of alpha defensin, leukocyte esterase, C-reactive protein (CRP), and white blood cells (WBCs) in synovial fluids alone and in combination for diagnosis of prosthetic joint infection was evaluated. Read More

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http://journals.sagepub.com/doi/10.1177/2058738418806072
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http://dx.doi.org/10.1177/2058738418806072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213302PMC
November 2018
4 Reads

Autoimmune inner ear disease (AIED): A diagnostic challenge.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418808680

1 Audiology and ENT Clinic, University of Ferrara, Ferrara, Italy.

Autoimmune inner ear disease (AIED) has been defined as a condition of bilateral sensorineural hearing loss (SNHL), caused by an 'uncontrolled' immune system response. The inner ear can be the direct target of the immune response, but it can be additionally damaged by a deposition of circulating immune complexes or by systemic immune-mediated diseases. The clinical expression of immune-mediated inner ear disease shows a progressive bilateral and asymmetric SNHL profile, which typically benefits from a steroid and immunosuppressive therapy. Read More

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http://dx.doi.org/10.1177/2058738418808680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213300PMC
November 2018
34 Reads

Taurine attenuates acrylamide-induced axonal and myelinated damage through the Akt/GSK3β-dependent pathway.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418805322

1 The First Affiliated Hospital of Dalian Medical University, Liaoning, China.

Acrylamide (ACR), formed during the Maillard reaction induced by high temperature in food processing, is one of the main causes of neurodegenerative diseases. Taurine, a free intracellular β-amino acid, is characterized by many functions, including antioxidation, anti-inflammatory, and neuroprotective properties. This promotes its application in the treatment of neurodegenerative diseases. Read More

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http://dx.doi.org/10.1177/2058738418805322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202743PMC
October 2018
4 Reads

Surgical treatment of non-tuberculous mycobacterial lymphadenitis in children: Our experience and a narrative review.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418806413

1 Department of Clinical Sciences and Community Health, Università Degli Studi Di Milano, Milan, Italy.

Non-tuberculous mycobacterial lymphadenitis (NTML) accounts for about 95% of the cases of head-and-neck mycobacterial lymphadenitis, and its prevalence has been increasing in the Western world. The diagnostic work-up can be challenging, and differential diagnoses such as tuberculous and suppurative lymphadenitis need to be considered. It may, therefore, not be diagnosed until the disease is in a late stage, by which time it becomes locally destructive and is characterized by a chronically discharging sinus. Read More

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http://dx.doi.org/10.1177/2058738418806413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202736PMC
October 2018

Domestic mite-induced allergy: Causes, diagnosis, and future prospects.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418804095

3 Department of Clinical Laboratory, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.

Allergies to various environmental factors, in particular mite species, represent a considerable healthcare burden with lost productivity resulting from symptoms including asthma, conjunctivitis, rhinitis, and atopic dermatitis. The complexity of mite species and the allergens that they produce complicates diagnosis and treatment; however, the advent of recombinant DNA technologies now allows clinicians to better pinpoint the specific sensitizing agents and creates new opportunities for avoidance or immunotherapy. Here we discuss the advantages and disadvantages of traditional and novel diagnostic and therapeutic platforms, with particular consideration given to multiplex tests able to generate patient-specific allergen profiles. Read More

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http://dx.doi.org/10.1177/2058738418804095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201173PMC
December 2018
4 Reads

Fatigue is common and severe in patients with mastocytosis.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418803252

2 Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.

Chronic fatigue is a common phenomenon in inflammatory and autoimmune conditions, in cancer, and in neurodegenerative diseases. Although pain and psychological factors influence fatigue, there is an increasing understanding that there is a genetic basis, and that activation of the innate immune system is an essential generator of fatigue. Mast cells are important actors in innate immunity and serve specialized defense responses against parasites and other pathogens. Read More

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http://dx.doi.org/10.1177/2058738418803252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201179PMC
December 2018
2 Reads

Saline nasal irrigations for chronic rhinosinusitis: From everyday practice to evidence-based medicine. An update.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418802676

5 Department of Otolaryngology and Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

Saline nasal irrigations (SNIs) are often recommended as an additional non-pharmacological treatment for adults with chronic rhinosinusitis (CRS), for which it could even be considered a first-line treatment. However, there is a wide range of different SNI protocols. The aim of this article is to review the published literature regarding all of the potential therapeutic effects of SNIs in adult CRS patients who had not undergone sinus surgery and clarify the role of the various saline nasal solutions and protocols (particularly the volume, frequency and duration of treatment), and describe the nasal devices used. Read More

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http://dx.doi.org/10.1177/2058738418802676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201180PMC
December 2018

Embryonal rhabdomyosarcoma within abdomen and pelvis in an adult.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418806728

Department of Gynecology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China.

Rhabdomyosarcoma arising in abdomen and pelvis is an uncommon but important type of soft tissue sarcoma, posing a great challenge for clinicians. Sporadic cases of intra-abdominal rhabdomyosarcoma were reported, but mostly in pediatrics. We demonstrated a rare case of primary abdominopelvic rhabdomyosarcoma in an elderly woman who presented with a notable increase in abdominal circumference and constipation. Read More

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http://dx.doi.org/10.1177/2058738418806728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201176PMC
December 2018
9 Reads

Histological and immunohistochemical evaluation of mandibular bone tissue regeneration.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418798249

2 Department of Histology, Cytology and Embryology, Nicolae Testemiţanu State University of Medicine and Pharmacy, Chișinău, Republic of Moldova.

The purpose of the study was to perform an immunohistochemical and histological evaluation of samples taken from different bone regeneration procedures in atrophic human mandible. 30 patients (15 men and 15 women, age range of 35-60 years), non-smokers, with good general and oral health were recruited in this study and divided into three groups. The first group included patients who were treated with blood Concentration Growth Factors (bCGF), the second group included patients who were treated with a mixture of bCGF and autologous bone, while the third group of patients was treated with bCGF and tricalcium phosphate/hydroxyapatite (TCP-HA). Read More

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http://dx.doi.org/10.1177/2058738418798249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201177PMC
December 2018
1 Read

Portrait of glial scar in neurological diseases.

Int J Immunopathol Pharmacol 2018 Jan-Dec;31:2058738418801406

7 Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Fibrosis is formed after injury in most of the organs as a common and complex response that profoundly affects regeneration of damaged tissue. In central nervous system (CNS), glial scar grows as a major physical and chemical barrier against regeneration of neurons as it forms dense isolation and creates an inhibitory environment, resulting in limitation of optimal neural function and permanent deficits of human body. In neurological damages, glial scar is mainly attributed to the activation of resident astrocytes which surrounds the lesion core and walls off intact neurons. Read More

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http://journals.sagepub.com/doi/10.1177/2058738418801406
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http://dx.doi.org/10.1177/2058738418801406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187421PMC
January 2019
1 Read

Marina crystal minerals (MCM) activate human dendritic cells to induce CD4+ and CD8+ T cell responses in vitro.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418797768

6 Division of Basic and Clinical Immunology, University of California, Irvine (UCI), Irvine, CA, USA.

Marina crystal minerals (MCM) are a mixture that contains crystallized minerals along with trace elements extracted from seawater. It is a nutritional supplement that is capable of enhancing natural killer (NK) cell activity and increasing T and B cell proliferation in humans post ingestion. However, its effect on dendritic cells (DCs), the cells that bridge innate and adaptive immunity, is not yet known. Read More

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http://dx.doi.org/10.1177/2058738418797768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168724PMC
December 2018

Food-dependent, exercise-induced anaphylaxis in a patient allergic to peach.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418803154

1 Department of Allergology, Clinical Immunology and Internal Diseases, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.

Determining the single factor that triggered anaphylactic shock can be challenging. We present an interesting case of a 25-year-old female patient with recurrent anaphylactic reactions developing after eating various foods, particularly in presence of co-factors of allergic reactions. Symptoms occurred after consumption of various kinds of foods - peach, pancakes with cottage cheese and fruit, a meal from a Chinese restaurant - all eaten on other occasions without symptoms. Read More

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http://dx.doi.org/10.1177/2058738418803154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168719PMC
December 2018
2 Reads

Cyclophosphamide eradicates murine immunogenic tumor coding for a non-self-antigen and induces antitumor immunity.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418796591

5 Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.

Although the majority of cancers respond to chemotherapy, most cancer types relapse, at least in part, due to the poor immunogenicity of most tumor. We have reported before that treatment of tumor bearing mice with a combination of the anti-cancer chemotherapy cyclophosphamide (CTX) and immunotherapy can result in complete tumor regression using T-cell receptor (TCR) transgenic CD8 T cells specific to antigens. This study aimed to determine whether chemotherapy can cure immunogenic tumor which expresses non-self-tumor antigen and result in antitumor immunity. Read More

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http://dx.doi.org/10.1177/2058738418796591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168726PMC
December 2018
22 Reads
2.507 Impact Factor

MicroRNA-145 attenuates IL-6-induced enhancements of sensitivity to UVB irradiation by suppressing MyD88 in HaCaT cells.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418795940

2 Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao, China.

MicroRNAs (miRNAs/miRs) play vital roles in various immune diseases including systemic lupus erythematosus (SLE). The current study aimed to assess the role of miR-145 in interleukin-6 (IL-6)-treated HaCaT cells under ultraviolet B (UVB) irradiation and further explore the potential regulatory mechanism. HaCaT cells were pretreated with IL-6 and then exposed to UVB to assess the effect of IL-6 on sensitivity of HaCaT cells to UVB irradiation. Read More

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http://journals.sagepub.com/doi/10.1177/2058738418795940
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http://dx.doi.org/10.1177/2058738418795940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131290PMC
December 2018
11 Reads

Analysis of peripheral blood lymphocyte subsets in critical patients at ICU admission: A preliminary investigation of their role in the prediction of sepsis during ICU stay.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418792310

4 Unit of Infectious Diseases, Pescara General Hospital, Pescara, Italy.

A better knowledge of factors predicting the development of sepsis in patients hospitalized in intensive care unit (ICU) might help deploy more targeted preventive and therapeutic strategies. In addition to the known clinical and demographic predictors of septic syndromes, in this study, we investigated whether measuring T and B lymphocyte subsets upon admission in the ICU may help individualize the prediction of ensuing sepsis during ICU stay. Between May 2015 and December 2016, we performed a prospective cohort study evaluating peripheral blood lymphocyte T-CD4+ (T-helper cells), T-CD8+ (cytotoxic T-cells), T-CD56 + (natural killer cells), and T-CD19+ (B-lymphocytes), using flow cytometry on blood samples collected 2 days after admission in the ICU. Read More

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http://dx.doi.org/10.1177/2058738418792310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100127PMC
December 2018
9 Reads

Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418781634

2 Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Oxymatrine (OMT) as a type of alkaloids collected from Sophora flavescens Ait exerts some biological functions including anticancer properties. Here, we investigated the therapeutic effects of OMT in gastric cancer cells (HGC 27 and AGS). As a result, the exposure of gastric cancer (GC) cells to OMT contributed to the suppression of cell proliferation and invasion. Read More

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http://dx.doi.org/10.1177/2058738418781634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096673PMC
December 2018
2 Reads

Characteristic patterns of HLA presentation and T cell differentiation in adult-onset Still's disease.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418791284

2 Department of Microbiology, School of Medicine, Ajou University, Suwon, Korea.

We examined the expression of human leukocyte antigen (HLA) and composition of differentiated T cells in the peripheral blood to understand the characteristics of the immune changes in patients with adult-onset Still's disease (AOSD). This study enrolled patients with AOSD (n = 14), patients with rheumatoid arthritis (RA, n = 20), and healthy controls (HC, n = 20). The percentage of surface-stained cells with HLA-DP, DQ, and DR alleles and the composition of differentiated T cells in peripheral blood leukocytes (PBLs) were evaluated by flow cytometry. Read More

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http://dx.doi.org/10.1177/2058738418791284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073833PMC
December 2018
2 Reads

Upregulation of PD-L1 predicts poor prognosis and is associated with miR-191-5p dysregulation in colon adenocarcinoma.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418790318

1 Department of Gastroenterology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Targeting of the programmed cell-death 1 ligand 1 (PD-L1) signal pathway is a promising treatment strategy in several cancers. The purpose of this study was to evaluate the clinical significance of PD-L1 in patients with colon adenocarcinoma (COAD). A total of 240 patients who were diagnosed with COAD from The Cancer Genome Atlas (TCGA) RNA-sequencing data and another cohort for pair-matched COAD samples (n = 40) in tissue microarray (TMA) were enrolled in this study. Read More

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http://dx.doi.org/10.1177/2058738418790318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073840PMC
December 2018
5 Reads

Erratum.

Authors:

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418789805

International Journal of Immunopathology and Pharmacology 2018; 32, 1-15 Michał Ciebiera, Marta Włodarczyk, Małgorzata Wrzosek, Cezary Wojtyła, Błażej Męczekalski, Grażyna Nowicka, Krzysztof Łukaszuk and Grzegorz Jakiel TNF-α serum levels are elevated in women with clinically symptomatic uterine fibroids 10.1177/2058738418779461 The original version of this article contained an error in the author name Błażej Męczekalski which was incorrectly given as Męczekalski Błażej. This has now been corrected. Read More

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http://dx.doi.org/10.1177/2058738418789805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055095PMC
December 2018
6 Reads

Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator-activated receptor γ activator-mediated inhibition of dendritic cells.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418787739

1 Nanotechnology Research Center, National Research Council Canada, Edmonton, AB, Canada.

Dendritic cell (DC) activation induces expression of co-stimulatory surface molecules, as well as migration into secondary lymphoid organs, where they activate naïve T-cells. A family of plant derivatives, eremophilane-type petasite sesquiterpenes, can regulate the immune system through DC targeting due to their anti-inflammatory effects. Peroxisome proliferator-activated receptor gamma (PPARγ) is involved in inhibition of inflammatory responses and induction of DCs to acquire a mucosal phenotype. Read More

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http://dx.doi.org/10.1177/2058738418787739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050815PMC
December 2018
7 Reads

IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans' islets, directly initiates NLRP3 inflammasome activation.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418788749

1 Department of Pathology, Proteo-Science Center and Graduate School of Medicine, Ehime University, Toon, Japan.

Recent findings revealed that type 2 diabetes mellitus (T2D) is a chronic inflammatory disease and an islet amyloid polypeptide (IAPP)/amylin, is deposited within pancreatic islets. IAPP/amylin has been reported to activate NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in infiltrated macrophages. NLRP3, an intracellular pattern recognition receptor, has been shown to recognize pathogens and/or metabolites and complexes with the adopter protein apoptosis-associated speck-like protein containing a caspase-recruitment domain ASC to form a huge complex, called an inflammasome, an interleukin (IL)-1β-processing platform. Read More

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http://dx.doi.org/10.1177/2058738418788749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050799PMC
December 2018
4 Reads

miR-149-5p inhibits cell growth by regulating TWEAK/Fn14/PI3K/AKT pathway and predicts favorable survival in human osteosarcoma.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418786656

Department of Orthopaedic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

MicroRNAs (miRNAs) as small non-coding RNAs act as either tumor suppressors or oncogenes in human cancers, of which miR-149-5p (miR-149) is involved in tumor growth and metastasis, but its role and molecular mechanisms underlying osteosarcoma growth are poorly understood. The correlation of miR-149 expression with clinicopathological characteristics and prognosis in patients with sarcoma was analyzed by The Cancer Genome Atlas (TCGA) RNA-sequencing data. Osteosarcoma cell growth affected by miR-149 was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and colony formation assays. Read More

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http://dx.doi.org/10.1177/2058738418786656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050806PMC
December 2018
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Leptin and camel milk abate oxidative stress status, genotoxicity induced in valproic acid rat model of autism.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418785514

2 Oral Biology Department, Faculty Oral and Dental Medicine, Cairo University, Egypt.

The aspect of treatment of autistic behaviour was investigated using valproic acid rat model of pregnant female rats. Two main groups (10 male rats/group) were treated for 6 days and then divided into six subgroups. The first group of normal rats was divided into three subgroups: (A) - control group, (B) - treated with camel milk (CAM; 2 mL/p. Read More

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http://dx.doi.org/10.1177/2058738418785514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047246PMC
December 2018
3 Reads

PCC0208009 enhances the anti-tumor effects of temozolomide through direct inhibition and transcriptional regulation of indoleamine 2,3-dioxygenase in glioma models.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418787991

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, P.R. China.

Indoleamine 2,3-dioxygenase (IDO), which is highly expressed in human glioblastoma and involved in tumor immune escape and resistance to chemotherapy, is clinically correlated with tumor progression and poor clinical outcomes, and is a promising therapeutic target for glioblastoma. IDO inhibitors are marginally efficacious as single-agents; therefore, combination with other therapies holds promise for cancer therapy. The aim of this study was to investigate the anti-tumor effects and mechanisms of the IDO inhibitor PCC0208009 in combination with temozolomide. Read More

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http://dx.doi.org/10.1177/2058738418787991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047256PMC
December 2018
16 Reads
2.507 Impact Factor

VEGF-R2 and TNF-R1 expression and cytokine production by samples of mammary adenocarcinomas and correlations with histopathological parameters of these malignant tumors.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418787990

4 Vector-Best Inc., Novosibirsk Region, Russia.

Currently, the role of cytokines in the tumor progression, including breast cancer, is universally recognized. At the same time, there are still many questions concerning the role of individual cytokines and receptors for cytokines in various morphogenetic processes underlying the tumor progression. The objective of this work was to study cytokine production and vascular endothelial growth factor (VEGF)-R2 and VEGF-R1 expression by mammary adenocarcinoma (MAC) and the correlations with histopathological parameters of malignant tumors. Read More

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http://dx.doi.org/10.1177/2058738418787990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073826PMC
December 2018
3 Reads

Orexin-A protects SH-SY5Y cells against HO-induced oxidative damage via the PI3K/MEK/ERK signaling pathway.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418785739

1 Neurobiology Key Laboratory of Jining Medical University in Colleges of Shandong, Jining, P.R. China.

Orexin-A elicits multiple potent effects on a variety of tumor cells via different signaling pathways. However, it is unknown whether it has a neuroprotective effect on SH-SY5Y human neuroblastoma cells. This study investigated the neuroprotective effect of Orexin-A against hydrogen peroxide (HO)-induced oxidative damage in SH-SY5Y cells and the underlying mechanism. Read More

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http://dx.doi.org/10.1177/2058738418785739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073832PMC
October 2018
5 Reads

Familial inheritance and screening of first-degree relatives in common variable immunodeficiency and immunoglobulin A deficiency patients.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418779458

1 Department of Pediatric Immunology, Faculty of Medicine, Ege University, Izmir, Turkey.

Common variable immunodeficiency (CVID) and immunoglobulin A deficiency (IgAD) are the most prevalent primary immunodeficiency disorders. High rates of familial inheritance have been described in CVID and IgAD, but it is unknown in different ethnic populations. We aimed to determine the prevalence of familial cases and whether they showed more severe clinical characteristics than sporadic ones in Turkish patients. Read More

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http://dx.doi.org/10.1177/2058738418779458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073834PMC
October 2018
23 Reads

Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418784431

4 Department of Physiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Zabrze, Poland.

LIGHT (homologous to lymphotoxins, exhibiting inducible expression, and competing with herpes simplex virus (HSV) glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) has been involved in various autoimmune and inflammatory disorders. LIGHT induces the expression of interleukin-8 (IL-8), which is up-regulated in chronic spontaneous urticaria (CSU). To determine circulating soluble LIGHT concentration and its relationship with IL-8 concentration in patients with CSU. Read More

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http://dx.doi.org/10.1177/2058738418784431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073820PMC
October 2018
15 Reads

An inhibitor of spleen tyrosine kinase suppresses experimental crescentic glomerulonephritis.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418783404

1 Department of Nephrology, Monash Medical Centre, Clayton, VIC, Australia.

Non-selective inhibitors of spleen tyrosine kinase (SYK) efficiently suppress disease in T cell-dependent models of crescentic glomerulonephritis. However, the therapeutic potential of selective SYK inhibitors in this disease has not been established. In addition, we lack knowledge regarding SYK expression in non-myeloid cells in glomerulonephritis. Read More

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http://dx.doi.org/10.1177/2058738418783404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024518PMC
October 2018
3 Reads

Cutaneous candidiasis caused by Candida albicans in a young non-immunosuppressed patient: an unusual presentation.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418781368

3 Plastic and Reconstructive Surgery Unit, Campus Bio-Medico University, Rome, Italy.

Candidiasis is a fungal infection caused by yeasts that belong to the genus Candida. There are over 20 species of Candida yeasts that can cause infection in humans, the most common of which is Candida albicans. Candida yeasts normally reside in the intestinal tract and can be found on mucous membranes and skin without causing infection. Read More

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http://dx.doi.org/10.1177/2058738418781368DOI Listing
October 2018
3 Reads

Polysaccharides from Citrus grandis associate with luteolin relieves chronic pharyngitis by anti-inflammatory via suppressing NF-κB pathway and the polarization of M1 macrophages.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418780593

1 Department of Otorhinolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Yantai, China.

Chronic pharyngitis is characterized as a common inflammation of the pharyngeal mucosa, and anti-inflammatory medications are the common treatment to relieve it. Polysacharides of Citrus grandis L. Osbeck (PCG) and luteolin have been reported to have anti-inflammatory activities. Read More

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http://dx.doi.org/10.1177/2058738418780593DOI Listing
October 2018
8 Reads

Hepatic artery resistive index as surrogate marker for fibrosis progression in NAFLD patients: A clinical perspective.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418781373

1 Internal Medicine and Critical Subacute Care Unit, Medicine Geriatric-Rehabilitation Department, University Hospital of Parma, Parma, Italy.

Ultrasound (US) can reveal the presence of steatosis in non-alcoholic fatty liver disease (NAFLD), but its diagnostic accuracy to reveal signs of fibrosis is low except in advanced stages of disease (e.g. cirrhosis). Read More

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http://dx.doi.org/10.1177/2058738418781373DOI Listing
October 2018
1 Read

Combinatory treatment using tacrolimus and a STAT3 inhibitor regulate Treg cells and plasma cells.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418778724

1 The Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Systemic lupus erythematosus (SLE; lupus) is a prototypical autoimmune disease characterized by circulating autoantibodies to nuclear antigens and immune complex deposition, resulting in damage to target organs. To investigate the effects of tacrolimus (TAC) on effector T cells and B cells, we examined its involvement in the development of effector T cells, germinal center (GC) B cells, and plasma cells in an in vitro system using wild-type (WT) and lupus-prone mice. The population of T helper (Th) 1, Th2, and Th17 cells interleukin (IL)-17-producing T (Th17) cells and the production of interferon-γ and interleukin-17A IL-17A were suppressed by TAC. Read More

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http://dx.doi.org/10.1177/2058738418778724DOI Listing
October 2018
2 Reads