1,956 results match your criteria International Journal of Immunopathology and Pharmacology [Journal]


Potential role of MRN-100, an iron-based compound, in upregulating production of cytokine IL-10 in human dendritic cells to promote an anti-inflammatory response in vitro.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419844932

4 Division of Basic and Clinical Immunology, University of California Irvine, Irvine, CA, USA.

The hydroferrate fluid MRN-100, an iron-based compound with potent antioxidant characteristics, was examined to identify its possible anti-inflammatory effects on human dendritic cells (DCs) in vitro. Human monocyte-derived DCs were treated with MRN-100 at two concentrations (50 and 100 μL/mL) for 24 h and then stimulated with or without lipopolysaccharides (LPS). The expression of DC maturation markers was assessed by flow cytometry and the production of cytokines was determined by enzyme-linked immunosorbent assay (ELISA). Read More

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http://dx.doi.org/10.1177/2058738419844932DOI Listing

Autoimmune thyroid disease following treatment with alemtuzumab for multiple sclerosis.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419843690

Department of Clinical and Experimental Medicine, University of Catania, Policlinico 'G. Rodolico', Catania, Italy.

Alemtuzumab, an anti-CD52 monoclonal antibody, is effective in the treatment of relapsing-remitting multiple sclerosis (RRMS). Common adverse effects include the development of autoimmune diseases, and Graves' disease is one of the most frequent presentations. We report here a case of alemtuzumab-induced thyroid disease in a female patient who showed a phase of thyrotoxicosis with positive anti-thyroglobulin (anti-Tg) and anti-thyroid peroxidase (TPO) antibodies, but a negative TSH receptor antibody, spontaneously followed by hypothyroidism. Read More

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http://dx.doi.org/10.1177/2058738419843690DOI Listing
April 2019
1 Read

Immunotherapy in gliomas: Are we reckoning without the innate immunity?

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419843378

4 Department of Health Sciences, University of Catanzaro "Magna Graecia," Catanzaro, Italy.

Innate immunity plays a central role in neoplasms, including those affecting the central nervous system (CNS). Nowadays, tumors classification, especially that regarding gliomas, is based on molecular features such as mutations in isocitrate dehydrogenase (IDH) genes and the presence of co-deletion 1p/19q. Therapy, in most cases, is based on surgery, radiotherapy, and pharmacological treatment with chemotherapeutic agents such as temozolomide. Read More

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http://journals.sagepub.com/doi/10.1177/2058738419843378
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http://dx.doi.org/10.1177/2058738419843378DOI Listing
April 2019
7 Reads

Is dextran sulfate sodium a good inducer of acute experimental enteritis?

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419843367

1 Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Animal models play critical roles in exploring the pathogenesis of human diseases and designing novel therapeutic schemes. Acute experimental colitis (AEC) models have been reported to be established in mice principally by oral administration of dextran sulfate sodium (DSS). However, little knowledge is known about whether DSS can be used to induce the acute experimental enteritis (AEE). Read More

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http://dx.doi.org/10.1177/2058738419843367DOI Listing
April 2019
5 Reads

PCC0208018 exerts antitumor effects by activating effector T cells.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419843366

1 School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China.

Poor prognosis is associated with melanoma due to immunosuppression profiles, suggesting that immune alterations have an important role in the occurrence, growth, and metastasis of melanoma. Here, we found that PCC0208018, a small-molecule compound, enhanced T cell proliferation and activation to release interferon gamma (IFN-γ) and interleukin-2 (IL-2) without blocking the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) binding and did not directly affect tumor cell viability in vitro. Furthermore, PCC0208018 increased the phosphorylation of protein kinase B (PKB/AKT) as well as extracellular regulated protein kinases (ERK) in human peripheral blood mononuclear cells (PBMCs) in vitro. Read More

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http://dx.doi.org/10.1177/2058738419843366DOI Listing
April 2019
3 Reads

Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419843381

1 Department of Clinical Immunology and Allergology, St. Anne's University Hospital, Brno, Czech Republic.

Common variable immunodeficiency disorders (CVIDs) represent a group of primary immunodeficiency diseases characterized by hypogammaglobulinemia and dysfunctional immune response to invading pathogens. Previous studies have indicated that CVID is associated with microbial translocation and systemic myeloid cell activation. The goal of this study was to determine whether patients with CVID display elevated systemic levels of markers of granulocyte activation and whether the levels are further influenced by intravenous immunoglobulin (IVIg) infusions. Read More

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http://dx.doi.org/10.1177/2058738419843381DOI Listing
April 2019
1 Read

Immunomodulatory effects of chemotherapy on blood lymphocytes and survival of patients with advanced non-small cell lung cancer.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419839592

1 Department of Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People's Republic of China.

A better understanding of the immune profile of non-small cell lung cancer (NSCLC) and the immunomodulatory impact of chemotherapy is essential to develop current therapeutic approaches. Herein, we collected peripheral blood from 20 healthy donors and 50 patients with advanced NSCLC, before and after chemotherapy, followed by phenotypic analysis of lymphocyte subsets and assessment of the correlation between their post-chemotherapy levels and progression-free survival (PFS). Results showed that, before chemotherapy, the levels of CD8 lymphocytes, PD-1CD4, Th2, and Th17 cells were elevated in patients' peripheral blood, in contrast to natural killer (NK) cells and Th1 cells. Read More

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http://dx.doi.org/10.1177/2058738419839592DOI Listing

Lifelong immunoglobulin replacement is not always necessary: A case description of a patient with recurrent infections and hypogammaglobulinemia.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419843364

5 Jan Biziel University Hospital No. 2, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.

Humoral immunodeficiency with accompanying infections is an indication for human immunoglobulin replacement therapy. Whether treatment will be lifelong or necessary only temporarily depends on the nature of deficiency: primary (persistent) or secondary (persistent or transient). It is not always easy to distinguish between primary and secondary immunodeficiency, especially in adults. Read More

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http://dx.doi.org/10.1177/2058738419843364DOI Listing
April 2019
1 Read

MiR-516a-5p inhibits the proliferation of non-small cell lung cancer by targeting HIST3H2A.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419841481

1 Shanghai Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

The dysregulation of microRNAs (miRNAs) is associated with the pathogenesis of non-small cell lung cancer (NSCLC). However, the mechanisms by which miR-516a-5p contributes to NSCLC remain unclear. The association between miR-516a-5p expression and the clinicopathological characteristics and prognosis in patients with NSCLC was analyzed by The Cancer Genome Atlas (TCGA) data set. Read More

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http://dx.doi.org/10.1177/2058738419841481DOI Listing
April 2019
3 Reads

CD3, CD4, CD8, CD19 and CD16/CD56 positive cells in tuberculosis infection and disease: Peculiar features in children.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419840241

Department of Health Sciences and Anna Meyer Children's University Hospital, University of Florence, Florence, Italy.

Pathogenesis of mycobacterial infection has been extensively studied determining the fundamental role of host immunocompetence in disease progression. Cellular adaptive immunity, in particular CD4+ cells, has shown to be crucial in the host defence. A role of cytotoxic lymphocytes and humoral immunity has also been established. Read More

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http://dx.doi.org/10.1177/2058738419840241DOI Listing

Effect of Chinese herbal compound GAPT on the early brain glucose metabolism of APP/PS1 transgenic mice.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419841482

1 Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine (BUCM), Beijing, China.

A number of studies have shown that early-stage Alzheimer's disease (AD) is associated with abnormal brain glucose metabolism before cognitive decline, which may be the key pathological change of asymptomatic AD. The pathogenesis of AD in traditional Chinese medicine is kidney deficiency and turbid phlegm. Based on this, GAPT (a mixture of herbal extracts) was made to invigorate kidney Yang and eliminate phlegm. Read More

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http://dx.doi.org/10.1177/2058738419841482DOI Listing

The neuropathic pain: An overview of the current treatment and future therapeutic approaches.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419838383

1 I.R.C.C.S. Centro Neurolesi Bonino Pulejo, Messina, Italy.

Neuropathic pain is characterized by abnormal hypersensitivity to stimuli (hyperalgesia) and nociceptive responses to non-noxious stimuli (allodynia). The conditions and the pathophysiological states that determine the onset of neuropathic pain are heterogeneous, such as metabolic disorders, neuropathy caused by viral infections, and autoimmune diseases affecting the central nervous system (CNS). Neuropathic pain in the general population is estimated to have a prevalence ranging between 3% and 17%. Read More

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http://dx.doi.org/10.1177/2058738419838383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431761PMC

Levels and effectiveness of oral retinol supplementation in VLBW preterm infants.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418820484

1 Neonatal Immunology Laboratory, UOC Neonatology and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Retinol palmitate oral administration is convenient, but it is difficult to assess/monitor its nutritional status in preterm infants and literature is controversial about the administration route and the effectiveness of vitamin A supplementation. We primarily evaluated retinol plasma levels to assess the vitamin A nutritional status in preterm infants (<1500 g; 32 weeks) after 28 days of oral supplementation (3000 IU/kg/day, retinol palmitate drops), in addition to vitamin A standard amount as suggested by European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines. We then observed the rate of typical preterm pathologies in the supplemented group (31 newborns) and in 10 matching preterm infants, hospitalized in neonatal intensive care unit (NICU) in the same period, who received neither vitamin A supplementation nor parents allowed plasma sampling. Read More

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http://dx.doi.org/10.1177/2058738418820484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311539PMC
March 2019
1 Read

Metformin inhibits both oleic acid-induced and CB1R receptor agonist-induced lipid accumulation in Hep3B cells: The preliminary report.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419832714

1 Department of Virology and Immunology, Maria Curie-Skłodowska University, Lublin, Poland.

Fatty liver is characterized by excessive accumulation of triglycerides within hepatocytes. Recent findings indicate that natural history of nonalcoholic fatty liver is regulated, in part, by endogenous cannabinoids. Metformin is an oral hypoglycemic medication which inhibits gluconeogenesis and glycogenolysis in hepatocytes and limits lipid storage in the liver through the inhibition of free fatty acid formation via induction of activated protein kinase activity (AMPK). Read More

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http://dx.doi.org/10.1177/2058738419832714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423672PMC

Vitamin D serum levels in children with vernal keratoconjunctivitis and disease control.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419833468

5 Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

The aim of this study was to evaluate whether the control of ocular symptoms with cyclosporine or with tacrolimus in eye drops allows to improve sun exposure and therefore serum level of vitamin D (VD; 25OHD), in the more severe forms of vernal keratoconjunctivitis (VKC). Out of 242 children followed for active VKC, 94 were treated with 1% cyclosporine or 0.1% tacrolimus eye drops, while the other 148 with mild VKC did not need to be treated with immunomodulators. Read More

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http://dx.doi.org/10.1177/2058738419833468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407325PMC
March 2019
7 Reads

Effect of voluntary running on expression of myokines in brains of rats with depression.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419833533

5 Good Samaritan Hospital, Dayton, OH, USA.

This study aimed to demonstrate the histopathology and immunoexpression of exercise-derived myokines in dentate gyrus (DG), medial prefrontal cortex (mPFC) and cerebellum of depressed Wistar rats during depression and after practising voluntary running. Depression was developed by forced swimming for 2 weeks. Voluntary running was performed by voluntary running for 3 weeks. Read More

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http://dx.doi.org/10.1177/2058738419833533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407323PMC
March 2019
2 Reads

Eosinophilic oesophagitis (in nickel-allergic patient) regressed after nickel oral desensitization: A case report.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419827771

3 Endoscopic Digestive Surgery, IRCCS Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.

The eosinophilic oesophagitis (EoE) is a chronic immune/antigen disorder of the oesophagus clinically characterized by dysphagia and pathologically by mucosa eosinophilic infiltration. Th2-type allergic reactions are considered having important roles in the aetiopathogenesis of EoE. Avoidance of food allergens, administration of steroidal anti-inflammatory medications and dilation of the oesophagus are the most important treatments. Read More

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http://dx.doi.org/10.1177/2058738419827771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407324PMC
March 2019
8 Reads

Effect of short peptides on neuronal differentiation of stem cells.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419828613

2 Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg, Russia.

It has been demonstrated that short peptides play an important role in the transmission of biological information, modulation of transcription, and restoring genetically conditioned alterations occurring with age. Peptidergic regulation of homeostasis occupies an important place in physiological processes, which lead to the aging of cells, tissues, and organs, consisting in the involution of major regulatory systems-the nervous, the endocrine, and the immune. The effect of AED (Ala-Glu-Asp), KED (Lys-Glu-Asp), KE (Lys-Glu), AEDG (Ala-Glu-Asp-Gly) peptides and their compound on neuronal differentiation of human periodontal ligament stem cells (hPDLSCs) was studied by immunofluorescence and western blot analysis. Read More

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http://dx.doi.org/10.1177/2058738419828613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376556PMC
February 2019

LncRNA SNHG3 promotes cell growth by sponging miR-196a-5p and indicates the poor survival in osteosarcoma.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418820743

2 Department of Orthopedic Surgery, Shibei Hospital of Jingan District, Shanghai, China.

Abnormal expression of long noncoding RNAs (lncRNAs) is closely associated with the pathogenesis of multiple malignancies, and lncRNA small nucleolar RNA host genes (SNHGs) play critical roles in tumor progression. However, the mechanism by which SNHG3 contributes to osteosarcoma (OS) remains elusive. The association between SNHG3 expression and the clinicopathological characteristics in OS patients was analyzed using the TCGA (The Cancer Genome Atlas) dataset. Read More

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http://dx.doi.org/10.1177/2058738418820743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329016PMC
February 2019
1 Read

Antifungal activity in the methanolic, aqueous and hexane extracts of Calligonum polygonoides.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418821275

2 Department of Eastern Medicine, Directorate of Medical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.

Calligonum polygonoides is locally called as Phog which belongs to the Polygonaceae family. It is traditionally used as an antifungal. The methanolic extract, hexane extract, ethyl acetate extract and aqueous extract were screened against Candida albicans and Aspergillus niger in seven concentrations, that is, 1. Read More

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http://dx.doi.org/10.1177/2058738418821275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327324PMC
February 2019

Detection of Mycobacterium tuberculosis in AFB smear-negative sputum specimens through MTB culture and GeneXpert MTB/RIF assay.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419827174

1 Department of Allied Health Sciences, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan.

Tuberculosis (TB) is an important public health issue around the globe which is a chronic infectious disease and is still one of the major challenges for developing countries. The emergence of drug-resistant TB makes the condition worse and there is an urgent need of fast, highly sensitive diagnostic methods. This study was undertaken to evaluate the performance of GeneXpert MTB/RIF assay and MTB culture for the detection of Mycobacterium tuberculosis (MTB) in sputum smear-negative pulmonary TB/drug-resistant tuberculosis (DR-TB) suspects. Read More

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http://dx.doi.org/10.1177/2058738419827174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360468PMC
February 2019
2 Reads

Reuterinos as adjuvant for peri-implant treatment: A pilot study.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419827745

5 Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

The objective of this study was to evaluate the effects of lozenges-containing Lactobacillus reuteri as an adjuvant treatment of peri-implant mucositis and to detect the level of L. reuteri colonization in the peri-implant tissues of treated patients. A total of 10 patients were selected. Read More

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http://dx.doi.org/10.1177/2058738419827745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365990PMC
February 2019
2 Reads
2.507 Impact Factor

Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418820402

1 Department of Biochemistry, University of Otago, Dunedin, New Zealand.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a poorly understood disease affecting 0.2%-2% of the global population. To gain insight into the pathophysiology of ME/CFS in New Zealand, we examined the transcriptomes of peripheral blood mononuclear cells by RNA-seq analysis in a small well-characterized patient group (10 patients), with age/gender-matched healthy controls (10 control subjects). Read More

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http://dx.doi.org/10.1177/2058738418820402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350121PMC
February 2019
2 Reads

Blocking of checkpoint receptor PD-L1 aggravates osteoarthritis in macrophage-dependent manner in the mice model.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418820760

3 Department of Spinal Surgery, The Second Hospital of Shandong University, Jinan, China.

As a chronic degenerative joint disease, osteoarthritis is among the most common diseases all over the world. In osteoarthritis, inflammation plays an important role in the generation of joint symptoms and the development of disease. When the programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint is blocked, the antitumor immunity will be enhanced. Read More

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http://dx.doi.org/10.1177/2058738418820760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328950PMC
February 2019

Possible treatment for cutaneous lichen planus: An in vitro anti-inflammatory role of Angelica polysaccharide in human keratinocytes HaCaT.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418821837

Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Cutaneous lichen planus (CLP) is an autoimmune disease. Angelica polysaccharide (AP) has been found to exert immunomodulation activity. In this study, we explored the roles of AP in lipopolysaccharide (LPS)-induced inflammatory injury of human keratinocytes (HaCaT cells), as well as the underlying mechanisms. Read More

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http://dx.doi.org/10.1177/2058738418821837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328949PMC
February 2019
1 Read
2.507 Impact Factor

Effects of 12-months treatment with zoledronate or teriparatide on intima-media thickness of carotid artery in women with postmenopausal osteoporosis: A pilot study.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418822439

1 Endocrinology and Diabetology Service, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Atherosclerosis and osteoporosis are interrelated entities and share similar pathogenic mechanisms. Recent studies showed that key proteins of bone metabolism, such as osteoprotegerin (OPG) and osteopontin (OPN), are also involved in vascular atherosclerosis and calcifications. The carotid intima-media thickness (CA-IMT) is an early quantitative marker of generalized atherosclerosis. Read More

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http://dx.doi.org/10.1177/2058738418822439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327329PMC
February 2019

Tripterine up-regulates miR-223 to alleviate lipopolysaccharide-induced damage in murine chondrogenic ATDC5 cells.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418824521

Department of Orthopedics, Liaocheng Third People's Hospital, Liaocheng, China.

Tripterine, also known as celastrol, is a main natural ingredient in Tripterygium wilfordii. Tripterine has a variety of pharmacological functions, and the therapeutic potential of tripterine in many kinds of inflammation-linked diseases has been revealed. However, the function of tripterine on osteoarthritis still remains unclear. Read More

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http://dx.doi.org/10.1177/2058738418824521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350133PMC
February 2019
1 Read

Heat stress combined with lipopolysaccharide alter the activity and superficial molecules of peripheral monocytes.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419828891

1 Department of Critical Care Medicine, The Fifth Peoples' Hospital of Dongguan, Dongguan Hospital Affiliated to Jinan University, Dongguan, China.

The purpose of this study was to focus on the underlying relationship between the hyperactivity for the peripheral monocytes and heat stroke by investigating the inflammatory oxidative activity of and the expression of superficial molecules. Peripheral blood samples were collected from 10 healthy adult volunteers. Human blood monocytes were isolated by density gradient centrifugation and sequent adherent culture. Read More

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http://dx.doi.org/10.1177/2058738419828891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378461PMC
March 2019
2 Reads

Monomorphic epitheliotropic intestinal T-cell lymphoma may mimic intestinal inflammatory disorders.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419829387

3 Department of Pharmacology, Wuhan University, Wuhan, P.R. China.

There is a significant overlap between intestinal lymphoproliferative disorders (LPDs) and inflammatory conditions of the intestine, including inflammatory bowel disease (IBD), in clinical, endoscopic, or histologic appearance, leading to diagnostic challenges. We report two cases of monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) that were initially considered to be ulcerative colitis (UC) and lymphocytic colitis, respectively. Both patients presented with diarrhea and abdominal pain. Read More

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http://dx.doi.org/10.1177/2058738419829387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376542PMC
March 2019
1 Read

Lp-PLA, a new biomarker of vascular disorders in metabolic diseases.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419827154

1 Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Metabolic diseases are chronic disorders correlated to a greater risk of cardiovascular event and death. Recently, many data have sustained the biological link between microvascular dysfunction, oxidative stress, vascular inflammation, and metabolic diseases. The determination of new and specific blood biomarkers of vascular inflammation associated with obesity-related metabolic syndrome (MetS) and diabetes such as lipoprotein-associated phospholipase A (Lp-PLA) could be useful to identify subject with high risk of cardiovascular events. Read More

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http://dx.doi.org/10.1177/2058738419827154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360470PMC

Adipose tissue transplant in recurrent folliculitis decalvans.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418814688

Department of Plastic and Reconstructive Surgery, San Gallicano Dermatological Institute IRCCS, Rome, Italy.

Folliculitis decalvans is a rare clinical disorder classified as primary neutrophilic scarring alopecia with a slight preference for the male gender. Here, we report the use of autologous fat transplantation as a source of stem cell therapy for hair re-growth assisted by inflammatory action of the fat itself in a female patient. The patient underwent adipose transplantation in April and September 2017. Read More

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http://journals.sagepub.com/doi/10.1177/2058738418814688
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http://dx.doi.org/10.1177/2058738418814688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259063PMC
March 2019
18 Reads

Evaluation of antidiabetic activity of Ipomoea batatas L. extract in alloxan-induced diabetic rats.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418814678

4 College of Agriculture, University of Sargodha, Sargodha, Pakistan.

Different allopathic drugs are being used for the treatment of diabetes mellitus but more emphasis are being placed on the use of medicinal plants, herbs, and natural extracts of fruits and vegetables due to their easy availability, easy consummation with low cost, and with no well-reported side effects. White skinned sweet potato (WSSP; Ipomoea batatas L.) peel-off was selected to find out its antidiabetic potential as well as to explore the effects on selected biochemical parameters in diabetes-induced Wistar rats. Read More

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http://dx.doi.org/10.1177/2058738418814678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259064PMC
March 2019
24 Reads

Kaempferol inhibits proliferation, migration, and invasion of liver cancer HepG2 cells by down-regulation of microRNA-21.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418814341

4 Department of General Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.

Liver cancer is one of the most common and lethal cancers in human digestive system, which kills more than half a million people every year worldwide. This study aimed to investigate the effects of kaempferol, a flavonoid compound isolated from vegetables and fruits, on hepatic cancer HepG2 cell proliferation, migration, invasion, and apoptosis, as well as microRNA-21 (miR-21) expression. Cell viability was detected using cell counting kit-8 (CCK-8) assay. Read More

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http://dx.doi.org/10.1177/2058738418814341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259061PMC
March 2019
1 Read

Triptolide inhibits benign prostatic epithelium viability and migration and induces apoptosis via upregulation of microRNA-218.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418812349

2 Department of Urinary Surgery, Affiliated Hospital of Taishan Medical University, Taian, China.

Benign prostatic hypertrophy (BPH) has become a troublesome disease for elder men. Triptolide (TPL) has been reported to be a potential anticancer agent. However, the potential effects of TPL on BPH have not been shown out. Read More

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http://dx.doi.org/10.1177/2058738418812349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247479PMC
March 2019
2 Reads

Alpha defensin, leukocyte esterase, C-reactive protein, and leukocyte count in synovial fluid for pre-operative diagnosis of periprosthetic infection.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418806072

1 Laboratory of Clinical Chemistry and Microbiology, IRCCS Galeazzi Orthopedic Institute, Milan, Italy.

Synovial fluid analysis for diagnosis of prosthetic joint infections has gained increasing interest in the recent past when markers more specific for these infections than the serum ones have been identified. Despite the important steps forward, identification of a gold standard has not yet been identified. In this study, usefulness of alpha defensin, leukocyte esterase, C-reactive protein (CRP), and white blood cells (WBCs) in synovial fluids alone and in combination for diagnosis of prosthetic joint infection was evaluated. Read More

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http://journals.sagepub.com/doi/10.1177/2058738418806072
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http://dx.doi.org/10.1177/2058738418806072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213302PMC
March 2019
5 Reads

Autoimmune inner ear disease (AIED): A diagnostic challenge.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418808680

1 Audiology and ENT Clinic, University of Ferrara, Ferrara, Italy.

Autoimmune inner ear disease (AIED) has been defined as a condition of bilateral sensorineural hearing loss (SNHL), caused by an 'uncontrolled' immune system response. The inner ear can be the direct target of the immune response, but it can be additionally damaged by a deposition of circulating immune complexes or by systemic immune-mediated diseases. The clinical expression of immune-mediated inner ear disease shows a progressive bilateral and asymmetric SNHL profile, which typically benefits from a steroid and immunosuppressive therapy. Read More

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http://dx.doi.org/10.1177/2058738418808680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213300PMC
March 2019
49 Reads

Taurine attenuates acrylamide-induced axonal and myelinated damage through the Akt/GSK3β-dependent pathway.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418805322

1 The First Affiliated Hospital of Dalian Medical University, Liaoning, China.

Acrylamide (ACR), formed during the Maillard reaction induced by high temperature in food processing, is one of the main causes of neurodegenerative diseases. Taurine, a free intracellular β-amino acid, is characterized by many functions, including antioxidation, anti-inflammatory, and neuroprotective properties. This promotes its application in the treatment of neurodegenerative diseases. Read More

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http://dx.doi.org/10.1177/2058738418805322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202743PMC
March 2019
6 Reads

Surgical treatment of non-tuberculous mycobacterial lymphadenitis in children: Our experience and a narrative review.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418806413

1 Department of Clinical Sciences and Community Health, Università Degli Studi Di Milano, Milan, Italy.

Non-tuberculous mycobacterial lymphadenitis (NTML) accounts for about 95% of the cases of head-and-neck mycobacterial lymphadenitis, and its prevalence has been increasing in the Western world. The diagnostic work-up can be challenging, and differential diagnoses such as tuberculous and suppurative lymphadenitis need to be considered. It may, therefore, not be diagnosed until the disease is in a late stage, by which time it becomes locally destructive and is characterized by a chronically discharging sinus. Read More

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http://dx.doi.org/10.1177/2058738418806413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202736PMC
March 2019
1 Read

Domestic mite-induced allergy: Causes, diagnosis, and future prospects.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418804095

3 Department of Clinical Laboratory, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.

Allergies to various environmental factors, in particular mite species, represent a considerable healthcare burden with lost productivity resulting from symptoms including asthma, conjunctivitis, rhinitis, and atopic dermatitis. The complexity of mite species and the allergens that they produce complicates diagnosis and treatment; however, the advent of recombinant DNA technologies now allows clinicians to better pinpoint the specific sensitizing agents and creates new opportunities for avoidance or immunotherapy. Here we discuss the advantages and disadvantages of traditional and novel diagnostic and therapeutic platforms, with particular consideration given to multiplex tests able to generate patient-specific allergen profiles. Read More

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http://dx.doi.org/10.1177/2058738418804095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201173PMC
December 2018
7 Reads

Fatigue is common and severe in patients with mastocytosis.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418803252

2 Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.

Chronic fatigue is a common phenomenon in inflammatory and autoimmune conditions, in cancer, and in neurodegenerative diseases. Although pain and psychological factors influence fatigue, there is an increasing understanding that there is a genetic basis, and that activation of the innate immune system is an essential generator of fatigue. Mast cells are important actors in innate immunity and serve specialized defense responses against parasites and other pathogens. Read More

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http://dx.doi.org/10.1177/2058738418803252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201179PMC
December 2018
3 Reads

Saline nasal irrigations for chronic rhinosinusitis: From everyday practice to evidence-based medicine. An update.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418802676

5 Department of Otolaryngology and Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

Saline nasal irrigations (SNIs) are often recommended as an additional non-pharmacological treatment for adults with chronic rhinosinusitis (CRS), for which it could even be considered a first-line treatment. However, there is a wide range of different SNI protocols. The aim of this article is to review the published literature regarding all of the potential therapeutic effects of SNIs in adult CRS patients who had not undergone sinus surgery and clarify the role of the various saline nasal solutions and protocols (particularly the volume, frequency and duration of treatment), and describe the nasal devices used. Read More

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http://dx.doi.org/10.1177/2058738418802676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201180PMC
December 2018
2 Reads

Embryonal rhabdomyosarcoma within abdomen and pelvis in an adult.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418806728

Department of Gynecology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China.

Rhabdomyosarcoma arising in abdomen and pelvis is an uncommon but important type of soft tissue sarcoma, posing a great challenge for clinicians. Sporadic cases of intra-abdominal rhabdomyosarcoma were reported, but mostly in pediatrics. We demonstrated a rare case of primary abdominopelvic rhabdomyosarcoma in an elderly woman who presented with a notable increase in abdominal circumference and constipation. Read More

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http://dx.doi.org/10.1177/2058738418806728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201176PMC
December 2018
14 Reads

Histological and immunohistochemical evaluation of mandibular bone tissue regeneration.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418798249

2 Department of Histology, Cytology and Embryology, Nicolae Testemiţanu State University of Medicine and Pharmacy, Chișinău, Republic of Moldova.

The purpose of the study was to perform an immunohistochemical and histological evaluation of samples taken from different bone regeneration procedures in atrophic human mandible. 30 patients (15 men and 15 women, age range of 35-60 years), non-smokers, with good general and oral health were recruited in this study and divided into three groups. The first group included patients who were treated with blood Concentration Growth Factors (bCGF), the second group included patients who were treated with a mixture of bCGF and autologous bone, while the third group of patients was treated with bCGF and tricalcium phosphate/hydroxyapatite (TCP-HA). Read More

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http://dx.doi.org/10.1177/2058738418798249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201177PMC
December 2018
2 Reads

Portrait of glial scar in neurological diseases.

Int J Immunopathol Pharmacol 2018 Jan-Dec;31:2058738418801406

7 Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Fibrosis is formed after injury in most of the organs as a common and complex response that profoundly affects regeneration of damaged tissue. In central nervous system (CNS), glial scar grows as a major physical and chemical barrier against regeneration of neurons as it forms dense isolation and creates an inhibitory environment, resulting in limitation of optimal neural function and permanent deficits of human body. In neurological damages, glial scar is mainly attributed to the activation of resident astrocytes which surrounds the lesion core and walls off intact neurons. Read More

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http://journals.sagepub.com/doi/10.1177/2058738418801406
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http://dx.doi.org/10.1177/2058738418801406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187421PMC
January 2019
2 Reads

Marina crystal minerals (MCM) activate human dendritic cells to induce CD4+ and CD8+ T cell responses in vitro.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418797768

6 Division of Basic and Clinical Immunology, University of California, Irvine (UCI), Irvine, CA, USA.

Marina crystal minerals (MCM) are a mixture that contains crystallized minerals along with trace elements extracted from seawater. It is a nutritional supplement that is capable of enhancing natural killer (NK) cell activity and increasing T and B cell proliferation in humans post ingestion. However, its effect on dendritic cells (DCs), the cells that bridge innate and adaptive immunity, is not yet known. Read More

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http://dx.doi.org/10.1177/2058738418797768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168724PMC
December 2018
3 Reads

Food-dependent, exercise-induced anaphylaxis in a patient allergic to peach.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418803154

1 Department of Allergology, Clinical Immunology and Internal Diseases, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.

Determining the single factor that triggered anaphylactic shock can be challenging. We present an interesting case of a 25-year-old female patient with recurrent anaphylactic reactions developing after eating various foods, particularly in presence of co-factors of allergic reactions. Symptoms occurred after consumption of various kinds of foods - peach, pancakes with cottage cheese and fruit, a meal from a Chinese restaurant - all eaten on other occasions without symptoms. Read More

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http://dx.doi.org/10.1177/2058738418803154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168719PMC
December 2018
4 Reads

Cyclophosphamide eradicates murine immunogenic tumor coding for a non-self-antigen and induces antitumor immunity.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418796591

5 Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.

Although the majority of cancers respond to chemotherapy, most cancer types relapse, at least in part, due to the poor immunogenicity of most tumor. We have reported before that treatment of tumor bearing mice with a combination of the anti-cancer chemotherapy cyclophosphamide (CTX) and immunotherapy can result in complete tumor regression using T-cell receptor (TCR) transgenic CD8 T cells specific to antigens. This study aimed to determine whether chemotherapy can cure immunogenic tumor which expresses non-self-tumor antigen and result in antitumor immunity. Read More

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http://dx.doi.org/10.1177/2058738418796591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168726PMC
December 2018
29 Reads
2.507 Impact Factor

MicroRNA-145 attenuates IL-6-induced enhancements of sensitivity to UVB irradiation by suppressing MyD88 in HaCaT cells.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418795940

2 Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao, China.

MicroRNAs (miRNAs/miRs) play vital roles in various immune diseases including systemic lupus erythematosus (SLE). The current study aimed to assess the role of miR-145 in interleukin-6 (IL-6)-treated HaCaT cells under ultraviolet B (UVB) irradiation and further explore the potential regulatory mechanism. HaCaT cells were pretreated with IL-6 and then exposed to UVB to assess the effect of IL-6 on sensitivity of HaCaT cells to UVB irradiation. Read More

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http://journals.sagepub.com/doi/10.1177/2058738418795940
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http://dx.doi.org/10.1177/2058738418795940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131290PMC
December 2018
16 Reads

Analysis of peripheral blood lymphocyte subsets in critical patients at ICU admission: A preliminary investigation of their role in the prediction of sepsis during ICU stay.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418792310

4 Unit of Infectious Diseases, Pescara General Hospital, Pescara, Italy.

A better knowledge of factors predicting the development of sepsis in patients hospitalized in intensive care unit (ICU) might help deploy more targeted preventive and therapeutic strategies. In addition to the known clinical and demographic predictors of septic syndromes, in this study, we investigated whether measuring T and B lymphocyte subsets upon admission in the ICU may help individualize the prediction of ensuing sepsis during ICU stay. Between May 2015 and December 2016, we performed a prospective cohort study evaluating peripheral blood lymphocyte T-CD4+ (T-helper cells), T-CD8+ (cytotoxic T-cells), T-CD56 + (natural killer cells), and T-CD19+ (B-lymphocytes), using flow cytometry on blood samples collected 2 days after admission in the ICU. Read More

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http://dx.doi.org/10.1177/2058738418792310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100127PMC
December 2018
10 Reads

Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418781634

2 Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Oxymatrine (OMT) as a type of alkaloids collected from Sophora flavescens Ait exerts some biological functions including anticancer properties. Here, we investigated the therapeutic effects of OMT in gastric cancer cells (HGC 27 and AGS). As a result, the exposure of gastric cancer (GC) cells to OMT contributed to the suppression of cell proliferation and invasion. Read More

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http://dx.doi.org/10.1177/2058738418781634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096673PMC
December 2018
3 Reads