2,502 results match your criteria International Journal of Hyperthermia [Journal]


Biofunctionalization of magnetite nanoparticles with stevioside: effect on the size and thermal behaviour for use in hyperthermia applications.

Int J Hyperthermia 2019 Feb 7:1-11. Epub 2019 Feb 7.

a Institute of Nano Science and Technology , Mohali , Punjab , India.

Controlling the magnetic properties of a nanoparticle efficiently via its particle size to achieve optimized heat under alternating magnetic field is the central point for magnetic hyperthermia-mediated cancer therapy (MHCT). Here, we have shown the successful use of stevioside (a natural plant-based glycoside) as a promising biosurfactant to control the magnetic properties of FeO nanoparticles by controlling the particle size. The biocompatibility and cellular uptake efficiency by rat C6 glioma cells and calorimetric magnetic hyperthermia profile of the nanoparticles were further examined. Read More

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http://dx.doi.org/10.1080/02656736.2019.1565787DOI Listing
February 2019

A novel software platform for volumetric assessment of ablation completeness.

Int J Hyperthermia 2019 Feb 7:1-7. Epub 2019 Feb 7.

b Department of Biomedical Sciences , Humanitas University , Rozzano , Milan , Italy.

Purpose: To retrospectively evaluate the accuracy of a novel software platform for assessing completeness of percutaneous thermal ablations.

Materials & Methods: Ninety hepatocellular carcinomas (HCCs) in 50 patients receiving percutaneous ultrasound-guided microwave ablation (MWA) that resulted in apparent technical success at 24-h post-ablation computed tomography (CT) and with ≥1-year imaging follow-up were randomly selected from a 320 HCC ablation database (2010-2016). Using a novel volumetric registration software, pre-ablation CT volumes of the HCCs without and with the addition of a 5 mm safety margin, and corresponding post-ablation necrosis volumes were segmented, co-registered and overlapped. Read More

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http://dx.doi.org/10.1080/02656736.2019.1569267DOI Listing
February 2019
1 Read

Radiofrequency endometrial ablation for treating heavy menstrual bleeding in women with chronic renal failure.

Int J Hyperthermia 2018 1;35(1):612-616. Epub 2018 Nov 1.

a Department of Obstetrics and Gynecology , The Third Xiangya Hospital of Central South University , Changsha , China.

Objective: The study objective was to retrospectively evaluate the efficacy and safety of radiofrequency endometrial ablation in treating heavy menstrual bleeding (HMB) in women with chronic renal failure (CRF).

Method: Fifty-eight patients with CRF undergoing radiofrequency endometrial ablation in our hospital between January 2013 and July 2017 and for whom complete follow-up data were available were included. Outcome measures included amenorrhea, treatment failure and operative complications. Read More

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http://dx.doi.org/10.1080/02656736.2018.1515445DOI Listing
November 2018
1 Read

Activated hepatic stellate cells promote progression of post-heat residual hepatocellular carcinoma from autophagic survival to proliferation.

Int J Hyperthermia 2019 Jan 31:1-11. Epub 2019 Jan 31.

a Zhongshan Hospital Fudan University and Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education, Liver Cancer Institute , Shanghai , China.

Background: Microscopic residual tumor often occurs after thermal ablation for medium-large hepatocellular carcinoma (HCC), leading to early aggressive recurrence or late relapse during follow-up. The mechanism how microscopic residual HCC cells survive sublethal heat stress and develop rapid outgrowth remains poorly understood.

Methods: HCC cells were exposed to sublethal heat treatment and co-cultured with conditioned media from activated HSCs (HSC-CM). Read More

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http://dx.doi.org/10.1080/02656736.2018.1558459DOI Listing
January 2019
2 Reads

'Relationship between thermal dose and cell death for "rapid" ablative and "slow" hyperthermic heating'.

Int J Hyperthermia 2019 Jan 31:1-15. Epub 2019 Jan 31.

a Joint Department of Physics, Division of Radiotherapy and Imaging , The Institute of Cancer Research: Royal Marsden Hospital , Sutton , UK.

Aim: Thermal isoeffective dose (TID) has not been convincingly validated for application to predict biological effects from rapid thermal ablation (e.g., using >55 °C). Read More

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http://dx.doi.org/10.1080/02656736.2018.1558289DOI Listing
January 2019

Predictive value of the albumin-bilirubin grade on long-term outcomes of CT-guided percutaneous microwave ablation in intrahepatic cholangiocarcinoma.

Int J Hyperthermia 2019 Jan 28:1-9. Epub 2019 Jan 28.

a Department of Minimally Invasive Interventional Radiology , Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Cancer for Cancer Medicine , Guangzhou , PR China.

Purpose: To assess the efficacy of the albumin-bilirubin (ALBI) grade on assessing long-term outcomes of computed tomography (CT)-guided percutaneous microwave ablation (CT-PMWA) in the treatment of patients with intrahepatic cholangiocarcinoma (ICC).

Methods: Between April 2011 and March 2018, 78 patients who underwent CT-PMWA were enrolled in this study. Overall survival (OS) and recurrence-free survival (RFS) were compared in the groups stratified by the ALBI grade and Child-Pugh score. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2019.1
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http://dx.doi.org/10.1080/02656736.2019.1567834DOI Listing
January 2019
3 Reads

US-guided microwave ablation for secondary hyperparathyroidism in patients after renal transplantation: a pilot study.

Int J Hyperthermia 2019 Jan 24:1-6. Epub 2019 Jan 24.

b Interventional Ultrasound Center , China-Japan Friendship Hospital , Beijing , China.

Objective: To assess the safety and efficacy of ultrasound-guided microwave ablation (MWA) in the treatment of patients who develop secondary hyperparathyroidism (SHPT) after renal transplantation (RT).

Methods: In total, nine patients, each with symptomatic SHPT caused by RT and at least one enlarged parathyroid gland, underwent MWA via hydrodissection. Intact parathyroid hormone (i-PTH), serum calcium, serum phosphorus, creatinine and blood urea nitrogen concentrations, before and after MWA, were assessed and compared. Read More

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http://dx.doi.org/10.1080/02656736.2019.1566580DOI Listing
January 2019
1 Read

Engineering T cell response to cancer antigens by choice of focal therapeutic conditions.

Int J Hyperthermia 2019 Jan 24:1-9. Epub 2019 Jan 24.

a Department of Mechanical Engineering , University of Minnesota , Minneapolis , MN , USA.

Focal thermal therapy (Heat), cryosurgery (Cryo) and irreversible electroporation (IRE) are increasingly used to treat cancer. However, local recurrence and systemic spread are persistent negative outcomes. Nevertheless, emerging work with immunotherapies (i. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1539253DOI Listing
January 2019
2 Reads

The treatment of cervical pregnancy with high-intensity focused ultrasound followed by suction curettage: report of three cases.

Int J Hyperthermia 2019 Jan 24:1-4. Epub 2019 Jan 24.

a Department of Obstetrics and Gynecology , The Third Xiangya Hospital of Central South University , Changsha , Hunan Province , China.

Objective: Cervical pregnancy (CP) is a rare type of ectopic pregnancy and is considered to be a life-threatening condition due to the risk of severe hemorrhage. Unfortunately, no consensus on standard conservative treatment for CP has been established. The study objective was to evaluate the efficacy and safety of high-intensity focused ultrasound (HIFU) followed by suction curettage for cervical pregnancy. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1563914DOI Listing
January 2019
4 Reads

Quality assurance guidelines for interstitial hyperthermia.

Int J Hyperthermia 2019 Jan 24:1-18. Epub 2019 Jan 24.

d Department of Radiation Oncology, Cancer Center Amsterdam , Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands.

Quality assurance (QA) guidelines are essential to provide uniform execution of clinical hyperthermia treatments and trials. This document outlines the clinical and technical consequences of the specific properties of interstitial heat delivery and specifies recommendations for hyperthermia administration with interstitial techniques. Interstitial hyperthermia aims at tumor temperatures in the 40-44 °C range as an adjunct to radiation or chemotherapy. Read More

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http://dx.doi.org/10.1080/02656736.2018.1564155DOI Listing
January 2019

Comparison of microwave ablation and radiofrequency ablation for hepatocellular carcinoma: a systematic review and meta-analysis.

Int J Hyperthermia 2019 Jan 24:1-9. Epub 2019 Jan 24.

a Department of Endoscopy , Sun Yat-sen University Cancer Center , Guangzhou , China.

Background: Microwave ablation (MWA) has several advantages over radiofrequency ablation (RFA) for the treatment of hepatocellular carcinoma (HCC). We aimed to compare the efficacy and safety of MWA with those of RFA for HCC from the perspectives of percutaneous and laparoscopic approaches.

Methods: PubMed/MEDLINE, Embase, the Cochrane library, and China Biology Medicine databases were searched. Read More

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http://dx.doi.org/10.1080/02656736.2018.1562571DOI Listing
January 2019

Nonresective treatments for uterine fibroids: a systematic review of uterine and fibroid volume reductions.

Int J Hyperthermia 2019 Jan 24:1-7. Epub 2019 Jan 24.

a Department of Gynaecology , St Mary's Hospital, Imperial College Healthcare Trust , London , UK.

Patients are increasingly seeking uterus-preserving, minimally invasive treatments for symptomatic uterine fibroids. This has led to a greater use of nonresective treatments such as uterine artery embolization (UAE), focused ultrasound (FUS) and more recently, radiofrequency ablation (RFA) of fibroids. This systematic review, following PRISMA guidelines, examines the change in uterine and fibroid volumes associated with UAE, FUS, and RFA. Read More

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http://dx.doi.org/10.1080/02656736.2018.1564843DOI Listing
January 2019

Efficacy and safety of high-intensity focused ultrasound ablation for hepatocellular carcinoma by changing the acoustic environment: microbubble contrast agent (SonoVue) and transcatheter arterial chemoembolization.

Int J Hyperthermia 2019 Jan 22:1-9. Epub 2019 Jan 22.

b Clinical Center for Tumor Therapy of the Second Affiliated Hospital of Chongqing Medical University , Chongqing , China.

Objective: To compare efficacy and safety of microbubble contrast agent (SonoVue) and transcatheter arterial chemoembolization (TACE) in combination with high-intensity focused ultrasound (HIFU) for treatment of patients with hepatocellular carcinoma (HCC).

Methods: According to our inclusion criteria, we retrospectively reviewed 52 patients with HCCs, and divided them into SonoVue group and TACE group. Tumors were examined by enhanced magnetic resonance imaging. Read More

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http://dx.doi.org/10.1080/02656736.2018.1558290DOI Listing
January 2019
1 Read

Efficacy of cryoablation combined with sorafenib for the treatment of advanced renal cell carcinoma.

Int J Hyperthermia 2019 Jan 21:1-9. Epub 2019 Jan 21.

a Department of Interventional Treatment , Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer , Tianjin , China.

Objective: To determine the safety and efficacy of cryoablation combined with sorafenib for the treatment of advanced renal cell carcinoma.

Material And Methods: We conducted an observational study in 156 patients with advanced renal cell carcinoma unsuitable for surgical treatment. Participants received cryoablation + sorafenib (n = 67) or sorafenib only (n = 89). Read More

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http://dx.doi.org/10.1080/02656736.2018.1556819DOI Listing
January 2019
2 Reads

The value of KRAS gene status in predicting local tumor progression of colorectal liver metastases following radiofrequency ablation.

Int J Hyperthermia 2019 Jan 21:1-9. Epub 2019 Jan 21.

a Department of Ultrasound, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) , Peking University Cancer Hospital and Institute , Beijing , China.

Purpose: We investigated the relationships between KRAS gene status and local tumor progression (LTP) of colorectal liver metastases (CLMs) after treatment with percutaneous ultrasound-guided radiofrequency ablation (RFA).

Materials And Methods: Clinical and imaging data from 76 patients (154 lesions) with CLM who underwent percutaneous ultrasound-guided RFA and had KRAS gene test results between January 2012 and June 2016 were analyzed. The average lesion size was 2. Read More

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http://dx.doi.org/10.1080/02656736.2018.1556818DOI Listing
January 2019
2 Reads

Management strategy for nerve damage during radiofrequency ablation of thyroid nodules.

Int J Hyperthermia 2019 Jan 14:1-7. Epub 2019 Jan 14.

a Department of Radiology and the Research Institute of Radiology, Asan Medical Center , University of Ulsan College of Medicine , Seoul , Korea.

Objective: The aim of this study was to introduce a management strategy for nerve damage occurring during radiofrequency ablation (RFA).

Methods: From January 2016 to October 2017, 17 patients who experienced the symptoms of nerve damage during RFA were enrolled in this study. If damage to nerves was suspected during RFA, ablation was stopped immediately, and a cold solution of 5% dextrose was injected directly into the space where the nerves were located until symptoms improved. Read More

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http://dx.doi.org/10.1080/02656736.2018.1554826DOI Listing
January 2019
1 Read

High intensity focused ultrasound (HIFU) ablation of benign thyroid nodule is safe and efficacious in patients who continue taking an anti-coagulation or anti-platelet agent in the treatment period.

Int J Hyperthermia 2018 Dec 16:1-5. Epub 2018 Dec 16.

c Department of Radiology , The University of Hong Kong , Hong Kong , China.

Background: High intensity focused ultrasound (HIFU) ablation is a promising treatment for benign thyroid nodules but because bleeding complications can occur following any intervention to the thyroid gland, the safety and efficacy of HIFU ablation were evaluated in patients who continued taking an anti-coagulation or anti-platelet agent during treatment.

Methods: From 2015 to 2017, 303 patients who underwent a single-session ablation for a benign thyroid nodule were analyzed. The primary study endpoint was thyroid bleeding, intra-lesional or peri-thyroidal hematoma or neck bruising diagnosed within 4 days of the treatment. Read More

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http://dx.doi.org/10.1080/02656736.2018.1548034DOI Listing
December 2018

Quality of life and outcomes in patients with a large toxic adenoma undergoing laser ablation plus radioiodine vs lobectomy.

Int J Hyperthermia 2018 Dec 16:1-5. Epub 2018 Dec 16.

a Division of Endocrinology , "V. Fazzi" Hospital, Piazza F. Muratore , Lecce , Italy.

Purpose: Patients with toxic adenomas (TAs) that are too large to undergo radioactive iodine (RAI) treatment aimed at resolving hyperthyroidism and/or relieving mechanical pressure symptoms are referred to surgery. This prospective study aimed to assess the outcomes of combining laser ablation (LA) plus RAI vs lobectomy to treat large TAs in terms of clinical efficacy and the health-related quality of life (HRQoL).

Patients And Methods: Patients with TAs of volumes greater than 20 mL and a calculated therapeutic activity exceeding 600 Mbq were randomly assigned to undergo LA + RAI (Group A) or lobectomy (Group B). Read More

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http://dx.doi.org/10.1080/02656736.2018.1549335DOI Listing
December 2018
2 Reads

Temperature-controlled power modulation compensates for heterogeneous nanoparticle distributions: a computational optimization analysis for magnetic hyperthermia.

Int J Hyperthermia 2018 Dec 12:1-15. Epub 2018 Dec 12.

a Department of Mechanical Engineering, Whiting School of Engineering , Johns Hopkins University , Baltimore , MD , USA.

Purpose: To study, with computational models, the utility of power modulation to reduce tissue temperature heterogeneity for variable nanoparticle distributions in magnetic nanoparticle hyperthermia.

Methods: Tumour and surrounding tissue were modeled by elliptical two- and three-dimensional computational phantoms having six different nanoparticle distributions. Nanoparticles were modeled as point heat sources having amplitude-dependent loss power. Read More

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http://dx.doi.org/10.1080/02656736.2018.1538538DOI Listing
December 2018

Longer heating duration increases localized doxorubicin deposition and therapeutic index in Vx2 tumors using MR-HIFU mild hyperthermia and thermosensitive liposomal doxorubicin.

Int J Hyperthermia 2018 Dec 12:1-8. Epub 2018 Dec 12.

a Department of Radiology , UT Southwestern Medical Center , Dallas , TX , USA.

Thermosensitive liposomal doxorubicin (LTSL-Dox) combined with mild hyperthermia enhances the localized delivery of doxorubicin (Dox) within a heated region. The optimal heating duration and the impact of extended heating on systemic drug distribution are unknown. Here we evaluated local and systemic Dox delivery with two different mild hyperthermia durations (42 °C for 10 or 40 minutes) in a Vx2 rabbit tumor model. Read More

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http://dx.doi.org/10.1080/02656736.2018.1550815DOI Listing
December 2018
1 Read

Correction.

Authors:

Int J Hyperthermia 2018 ;35(1):140

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http://dx.doi.org/10.1080/02656736.2018.1539311DOI Listing
January 2018

The local efficacy and influencing factors of ultrasound-guided percutaneous microwave ablation in colorectal liver metastases: a review of a 4-year experience at a single center.

Int J Hyperthermia 2018 Nov 29:1-8. Epub 2018 Nov 29.

a Department of Medical Ultrasonics , The Sixth Affiliated Hospital of Sun Yat-Sen University , Guangzhou , China.

Purpose: To investigate the clinical effectiveness and safety of ultrasound (US)-guided percutaneous microwave ablation (MWA) for colorectal liver metastasis (CRLM) and evaluate the influencing factors of local efficacy.

Methods: From January 2013 to January 2017, 137 CRLM patients accepting US-guided percutaneous MWA were included. The 2450-MHz microwave ablation system and a cooled-shaft antenna were used. Read More

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http://dx.doi.org/10.1080/02656736.2018.1528511DOI Listing
November 2018
1 Read

Radiofrequency ablation of liver cancers adjacent to the gallbladder without gallbladder isolation under contrast-enhanced ultrasound monitoring: a preliminary study.

Int J Hyperthermia 2018 Nov 29:1-6. Epub 2018 Nov 29.

a Department of Medical Ultrasonics, Guangdong Key Laboratory of Liver Disease Research , The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.

Purpose: The purpose of this study was to investigate the feasibility, safety and efficacy of intra-procedural contrast-enhanced ultrasound (CEUS) monitoring of the radiofrequency ablation (RFA) of liver cancers adjacent to gallbladder (GB) without GB isolation.

Materials And Methods: From May 2016 to July 2017, patients with liver cancers adjacent to GB (≤10 mm) who intended to undergo ultrasound-guided RFA without GB isolation in our hospital were prospectively enrolled. During the RFA procedures, CEUS was employed to evaluate the therapeutic response and the perfusion of the intact GB wall. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1539776DOI Listing
November 2018
8 Reads

SOCS3 control the activity of NF-κB induced by HSP70 via degradation of MyD88-adapter-like protein (Mal) in IPEC-J2 cells.

Int J Hyperthermia 2018 Nov 28:1-9. Epub 2018 Nov 28.

a Department of Veterinary Medicine , Guangdong Ocean University , Zhanjiang , China.

Hyperthermia in pigs induces suppressor of cytokine signaling (SOCS) 3 and SOCS4 expression in intestinal gut and causes disruption of inflammation cytokine production. These changes may affect the development of inflammatory bowel disease in heat-stressed pigs. However, the mechanisms are not well understood. Read More

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http://dx.doi.org/10.1080/02656736.2018.1541484DOI Listing
November 2018
9 Reads

Precoagulation with microwave ablation for hepatic parenchymal transection during liver partial resection.

Int J Hyperthermia 2018 Nov 28:1-5. Epub 2018 Nov 28.

b Hepatobiliary/Liver Transplantation Center , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.

Purpose: To evaluate the feasibility of precoagulation with microwave ablation (MWA) for hepatic parenchymal transection during liver partial resection.

Methods: A total of 66 eligible patients were enrolled in this double-blind, randomized, controlled study. Patients were randomized to receive either the traditional clamp-crushing method (Control group) or the MWA precoagulation method (MWA group) for hepatic parenchymal transection during liver partial resection. Read More

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http://dx.doi.org/10.1080/02656736.2018.1540799DOI Listing
November 2018
1 Read

Letter to the editor regarding quantitative dynamic contrast-enhanced ultrasound may help predict the outcome of hepatocellular carcinoma after microwave ablation.

Int J Hyperthermia 2018 Nov 28. Epub 2018 Nov 28.

e Department of Epidemiology and Health Statistics , West China School of Public Health, Sichuan University , Chengdu , People's Republic of China.

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http://dx.doi.org/10.1080/02656736.2018.1544380DOI Listing
November 2018

A new microwave applicator for laparoscopic and robotic liver resection.

Int J Hyperthermia 2018 Nov 28:1-12. Epub 2018 Nov 28.

d Department of Information Engineering , University of Florence , Firenze , Italy.

Purpose: Bleeding from parenchyma transection during a robotic hepatic surgery remains the most critical point affecting postoperative recovery and long-term survival. Various robotic devices with different types of energies have been proposed; however, each of these lack in steerability, efficacy, or accuracy. The aim of this work is to evaluate the feasibility and performance of a new steerable microwave resection device intended for minimizing intraoperative blood loss during laparoscopic and robotic liver resections. Read More

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http://dx.doi.org/10.1080/02656736.2018.1534004DOI Listing
November 2018
2 Reads

Motor performance is preserved in healthy aged adults following severewhole-body hyperthermia.

Int J Hyperthermia 2018 Nov 1:1-10. Epub 2018 Nov 1.

a Institute of Sport Science and Innovations , Lithuanian Sports University , Kaunas , LT , Lithuania.

Healthy aging is associated with a progressive decline in motor performance and thermoregulatory efficiency. Functional consequences of severe whole-body hyperthermia on neurophysiological functions in healthy aged men have not been investigated. To determine whether severe whole-body hyperthermia (increase in rectal temperature of about 2. Read More

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http://dx.doi.org/10.1080/02656736.2018.1533650DOI Listing
November 2018
1 Read

Three-dimensional contrast-enhanced ultrasound fusion imaging predicts local tumor progression by evaluating ablative margin of radiofrequency ablation for hepatocellular carcinoma: a preliminary report.

Int J Hyperthermia 2018 Nov 16:1-10. Epub 2018 Nov 16.

a Division of Interventional Ultrasound, Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound , The First Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.

Purpose: To investigate the feasibility of three-dimensional contrast-enhanced ultrasound (3DCEUS) fusion in evaluating ablative margin (AM) after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) and compare with those of computed tomography (CT) fusion.

Patients And Methods: In total, 55 patients (47 men, 8 women; mean age, 56.0 ± 10. Read More

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http://dx.doi.org/10.1080/02656736.2018.1530460DOI Listing
November 2018
10 Reads

Factors influencing MR changes associated with sacral injury after high-intensity focused ultrasound ablation of uterine fibroids.

Int J Hyperthermia 2018 Nov 14:1-8. Epub 2018 Nov 14.

a Department of Medical Imaging, The First Affiliated Hospital , Kunming Medical University , Kunming , China.

Purpose: We investigated the risk factors influencing MR changes associated with sacral injury from ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation for uterine fibroids.

Methods: We retrospectively analyzed a total of 346 patients with symptomatic uterine fibroids who received USgHIFU ablation. All of the patients underwent contrast-enhanced magnetic resonance imaging (CE-MRI) before and after treatment. Read More

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http://dx.doi.org/10.1080/02656736.2018.1528391DOI Listing
November 2018

Combined treatment with modulated electro-hyperthermia and an autophagy inhibitor effectively inhibit ovarian and cervical cancer growth.

Int J Hyperthermia 2018 Nov 14:1-12. Epub 2018 Nov 14.

a Department of Obstetrics and Gynecology, Gangnam Severance Hospital , Yonsei University College of Medicine , Seoul , Republic of Korea.

Purpose: Modulated electro-hyperthermia (mEHT), known as oncothermia, is an anticancer therapy that induces radiofrequency thermal damage to the cancer tissues. This study aimed to evaluate the potential effectiveness of mEHT as a therapeutic tool in ovarian and cervical cancer.

Materials And Methods: We used both tumor-bearing mice and ovarian and cervical OVCAR-3, SK-OV-3, HeLa and SNU-17 cancer cell lines to investigate the effects of mEHT in vivo and in vitro, respectively, and determine whether it was enhanced by cotreatment with an autophagy inhibitor. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1528390DOI Listing
November 2018
15 Reads

Polyethylene glycol-coated porous magnetic nanoparticles for targeted delivery of chemotherapeutics under magnetic hyperthermia condition.

Int J Hyperthermia 2018 Nov 14:1-11. Epub 2018 Nov 14.

h Department of Chemistry, Faculty of Science , University of Malaya , Kuala Lumpur , Malaysia.

Purpose: Although magnetite nanoparticles (MNPs) are promising agents for hyperthermia therapy, insufficient drug encapsulation efficacies inhibit their application as nanocarriers in the targeted drug delivery systems. In this study, porous magnetite nanoparticles (PMNPs) were synthesized and coated with a thermosensitive polymeric shell to obtain a synergistic effect of hyperthermia and chemotherapy.

Materials And Methods: PMNPs were produced using cetyltrimethyl ammonium bromide template and then coated by a polyethylene glycol layer with molecular weight of 1500 Da (PEG1500) and phase transition temperature of 48 ± 2 °C to endow a thermosensitive behavior. Read More

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http://dx.doi.org/10.1080/02656736.2018.1536809DOI Listing
November 2018
11 Reads
2.645 Impact Factor

Factors affecting effects of ultrasound guided high intensity focused ultrasound for single uterine fibroids: a retrospective analysis.

Int J Hyperthermia 2018 14;35(1):534-540. Epub 2018 Nov 14.

a Department of Medical Imaging , the First Affiliated Hospital, Kunming Medical University , Kunming , China.

Objective: To investigate factors affecting effects of ultrasound guided high intensity focused ultrasound (USgHIFU) in the treatment of single uterine fibroids (UFs) with different magnetic resonance imaging (MRI) features.

Methods: A total of 207 patients with single symptomatic UFs who were treated with HIFU were retrospectively analyzed. All UFs were grouped according to MRI features, and factors affecting HIFU ablation were set as independent variables. Read More

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http://dx.doi.org/10.1080/02656736.2018.1511837DOI Listing
November 2018
9 Reads
2.645 Impact Factor

Clinical analysis of high-intensity focussed ultrasound ablation for abdominal wall endometriosis: a 4-year experience at a specialty gynecological institution.

Int J Hyperthermia 2018 Nov 14:1-8. Epub 2018 Nov 14.

a Department of Gynecology Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital , Capital Medical University , Beijing , China.

Objective: To evaluate the long-term clinical effect of high-intensity focussed ultrasound (HIFU) as a non-invasive modality for ablation of abdominal wall endometriosis (AWE) foci.

Methods: All women who were diagnosed with cutaneous endometriosis and underwent HIFU ablation and 4-year follow-up were included. Patient symptoms, imaging performed, HIFU ablation, recurrence, lesion location, size and number were collected and analyzed. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1534276DOI Listing
November 2018
2 Reads

Thermal ablation of pancreatic cancer: A systematic literature review of clinical practice and pre-clinical studies.

Int J Hyperthermia 2018 14;35(1):398-418. Epub 2018 Nov 14.

d Fondazione Policlinico Universitario Agostino Gemelli IRCCS , Rome , Italy.

Purpose: Pancreatic cancer is a challenging malignancy with low treatment option and poor life expectancy. Thermal ablation techniques were proposed as alternative treatment options, especially in advanced stages and for unfit-for-surgery patients. This systematic review describes the thermal ablative techniques -i. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1506165DOI Listing
November 2018
10 Reads

Minimally invasive isolated limb perfusion - technical details and initial outcome of a new treatment method for limb malignancies.

Int J Hyperthermia 2018 14;35(1):667-673. Epub 2018 Nov 14.

a Department of Surgery, Institute of Clinical Sciences , Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital , Gothenburg , Sweden.

Objective: Isolated limb perfusion (ILP) and isolated limb infusion (ILI) are treatment options for patients with locally advanced melanomas and sarcomas of the extremities. ILP potentially have higher response rates, but requires open surgery for vascular access, whereas ILI is minimally invasive and easier to perform. We now present the technical details and outcome of a new approach to ILP by a minimally invasive vascular access (MI-ILP). Read More

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http://dx.doi.org/10.1080/02656736.2018.1522000DOI Listing
November 2018
11 Reads

Heat shock protein expression and autophagy after incomplete thermal ablation and their correlation.

Int J Hyperthermia 2018 Nov 14:1-9. Epub 2018 Nov 14.

a Hepatobiliary and Pancreatic Intervention Center, The First affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , China.

Objective: To establish a model of incomplete ablation in nude mice with hepatocellular carcinoma (HCC) and to evaluate heat shock protein (HSP) expression and autophagy and their correlation.

Materials And Methods: In the first stage, 12 nude mice with HCC were randomly divided into two groups (n = 6). A sham puncture operation was performed for one group, and palliative laser ablation was performed for the other group. Read More

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http://dx.doi.org/10.1080/02656736.2018.1536285DOI Listing
November 2018

Clinical validation of a novel thermophysical bladder model designed to improve the accuracy of hyperthermia treatment planning in the pelvic region.

Int J Hyperthermia 2018 1;35(1):383-397. Epub 2018 Nov 1.

a Department of Radiation Oncology , Academic Medical Center , Amsterdam , the Netherlands.

Purpose: Hyperthermia treatment planning for deep locoregional hyperthermia treatment may assist in phase and amplitude steering to optimize the temperature distribution. This study aims to incorporate a physically correct description of bladder properties in treatment planning, notably the presence of convection and absence of perfusion within the bladder lumen, and to assess accuracy and clinical implications for non muscle invasive bladder cancer patients treated with locoregional hyperthermia.

Methods: We implemented a convective thermophysical fluid model based on the Boussinesq approximation to the Navier-Stokes equations using the (finite element) OpenFOAM toolkit. Read More

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http://dx.doi.org/10.1080/02656736.2018.1506164DOI Listing
November 2018
1 Read

Vaginal delivery outcomes of pregnancies following ultrasound-guided high-intensity focused ultrasound ablation treatment for uterine fibroids.

Int J Hyperthermia 2018 25;35(1):510-517. Epub 2018 Oct 25.

a Department of Ultrasound , Chinese PLA General Hospital, Medical School of Chinese PLA , Beijing , China.

Objective: To evaluate the feasibility and safety of vaginal delivery after ultrasound-guided high-intensity focused ultrasound (HIFU) ablation treatment for women with uterine fibroids of child-bearing ages.

Methods: A prospective study was conducted on women who underwent ultrasound-guided HIFU therapy for uterine fibroids at the Chinese PLA General Hospital from January 2008 to December 2014. Patients were interviewed yearly to assess their fertility outcomes, including conception method, delivery mode, neonatal outcomes and complications during pregnancy, labor, and delivery. Read More

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http://dx.doi.org/10.1080/02656736.2018.1510548DOI Listing
October 2018
2 Reads
2.640 Impact Factor

Ultrasound-guided percutaneous microwave ablation assisted by athree-dimensional visualization treatment platform combined with transcatheter arterial chemoembolization for a single large hepatocellular carcinoma 5 cm or larger: a preliminary clinical application.

Int J Hyperthermia 2018 Oct 25:1-11. Epub 2018 Oct 25.

a Department of Interventional Ultrasound , Chinese PLA General Hospital , Beijing , China.

Objective: To assess the clinical efficiency and feasibility of ultrasound-guided percutaneous microwave ablation (US-PMWA) assisted by a three-dimensional (3D) visualization platform for treating a single large hepatocellular carcinoma (HCC) (diameter ≥5 cm).

Methods: We included 40 patients with a single large HCC from May 2015 to August 2017. Nineteen patients who underwent US-PMWA assisted by a 3D visualization platform formed the 3D group; 21 patients without 3D visualization assistance formed the control group. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1530459DOI Listing
October 2018
6 Reads
2.645 Impact Factor

Effect of intraoperative dexmedetomidine on renal function after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a randomized, placebo-controlled trial.

Int J Hyperthermia 2018 Oct 25:1-8. Epub 2018 Oct 25.

a Department of Anesthesiology and Pain Medicine , Yonsei University College of Medicine , Seoul , Republic of Korea.

Introduction: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) predispose to postoperative renal dysfunction. Dexmedetomidine is an α adrenoreceptor agonist, which has renoprotective effects after cardiac surgery.

Objective: To assess the effect of dexmedetomidine on renal function after CRS and HIPEC. Read More

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http://dx.doi.org/10.1080/02656736.2018.1526416DOI Listing
October 2018
1 Read

A network meta-analysis on the efficacy and prognosis of different interventional therapies for early-stage hepatocellular carcinoma.

Int J Hyperthermia 2018 25;35(1):450-462. Epub 2018 Oct 25.

a Department of Ultrasonography , China-Japan Union Hospital of Jilin University , Changchun , Jilin Province , China.

Purpose: It is unclear which kind of interventional therapies is the best when treating early-stage hepatocellular carcinoma (HCC). We conducted Bayesian network meta-analyses to compare local tumor progression (LTP), total tumor recurrence and survival rates and to rank the best intervention arm.

Materials And Methods: A literature search of Pubmed, Embase, Cochrane library and Clinicaltrials. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1507047DOI Listing
October 2018
6 Reads

Ultrasound single-phase CBE imaging for monitoring radiofrequency ablation.

Int J Hyperthermia 2018 25;35(1):548-558. Epub 2018 Oct 25.

c Department of Medical Imaging and Radiological Sciences , College of Medicine, Chang Gung University , Taoyuan , Taiwan.

Radiofrequency (RF) ablation (RFA) is the most commonly used minimally invasive procedure for thermal ablation of liver tumors. Ultrasound not only provides real-time feedback of the electrode location for RFA guidance but also enables visualization of the tissue temperature. Changes in backscattered energy (CBE) have been widely applied to ultrasound temperature imaging for assessing thermal ablation. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1512160DOI Listing
October 2018
11 Reads

Validation of hybrid angular spectrum acoustic and thermal modelling in phantoms.

Int J Hyperthermia 2018 15;35(1):578-590. Epub 2018 Oct 15.

c Department of Radiology and Imaging Sciences , University of Utah , Salt Lake City , UT, USA.

In focused ultrasound (FUS) thermal ablation of diseased tissue, acoustic beam and thermal simulations enable treatment planning and optimization. In this study, a treatment-planning methodology that uses the hybrid angular spectrum (HAS) method and the Pennes' bioheat equation (PBHE) is experimentally validated in homogeneous tissue-mimicking phantoms. Simulated three-dimensional temperature profiles are compared to volumetric MR thermometry imaging (MRTI) of FUS sonications in the phantoms, whose acoustic and thermal properties are independently measured. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1513168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365205PMC
October 2018
10 Reads

Programmed death-ligand 1 expression and CD8+ tumor-infiltrating lymphocytes in advanced non-small cell lung cancer treated with microwave ablation and chemotherapy.

Int J Hyperthermia 2018 11;35(1):591-598. Epub 2018 Oct 11.

a Department of Oncology , Shandong Provincial Hospital Affiliated to Shandong University , Shandong Province , China.

Background: Programmed death-ligand 1 (PD-L1) and CD8+ tumor-infiltrating lymphocytes (TILs) were associated with non-small cell lung cancer (NSCLC). We conducted this study to evaluate the correlation between PD-L1 or CD8+ TILs expression and MWA or survival in advanced NSCLC patients treated with microwave ablation (MWA) plus chemotherapy.

Methods: Previously untreated, pathologically verified advanced NSCLC patients with adequate tissues for the analysis of PD-L1 expression and the presence of CD8+ TILs were retrospectively enrolled. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1513169DOI Listing
October 2018
3 Reads

Percutaneous image-guided ablation of bone metastases: local tumor control in oligometastatic patients.

Int J Hyperthermia 2018 11;35(1):493-499. Epub 2018 Oct 11.

a Interventional Radiology , University Hospital of Strasbourg , Strasbourg , France.

Introduction: Percutaneous image-guided cryo- (CA) and radiofrequency- (RFA) ablations have been widely used in the treatment of painful bone metastases (BM). However, paucity of data is available for the performance of these treatments when used with a curative intent. The aim of this study is to investigate the local progression free-survival (LPFS) after radical percutaneous image-guided ablation of BM in oligometastatic patients, and to identify predictive factors associated with local tumor progression. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1508760DOI Listing
October 2018
5 Reads

Numerical analysis of thermal response of tissues subjected to high intensity focused ultrasound.

Int J Hyperthermia 2018 11;35(1):419-434. Epub 2018 Oct 11.

b Department of Mechanical Engineering , Indian Institute of Technology Bombay , Mumbai , India.

The present work is concerned with the numerical investigation of the thermal response of tissue-mimicking biological phantom(s) subjected to high intensity focused ultrasound (HIFU). Simulations have been performed on the 3-dimensional physical domain for two-layered as well as multi-layered medium consisting of water and liver tissue. Local pressure distribution within the body of the phantom has been calculated by solving the complete full-wave nonlinear form of Westervelt equation. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1506166DOI Listing
October 2018
2 Reads

Magnetic resonance imaging features influencing high-intensity focused ultrasound ablation of adenomyosis with a nonperfused volume ratio of ≥90% as a measure of clinical treatment success: retrospective multivariate analysis.

Int J Hyperthermia 2018 11;35(1):626-636. Epub 2018 Oct 11.

c Department of Radiology , Pham Ngoc Thach University of Medicine , Ho Chi Minh City , Viet Nam.

Objective: This retrospective study aimed (1) to investigate the magnetic resonance imaging (MRI) features influencing a nonperfused volume ratio (NPVr) ≥ 90% after high-intensity focussed ultrasound (HIFU) ablation of adenomyosis, and (2) to assess the safety, which was defined in terms of adverse events (AEs) and changes in anti-Mullerian hormone (AMH) concentrations, and clinical efficacy, which was defined in terms of adenomyosis volume reduction and symptom improvement at 6 months' follow-up.

Methods: Sixty-six women who underwent HIFU treatment were divided into groups A (NPVr ≥90%; n = 26) and B (NPVr <90%, n = 40). Multivariate logistic regression analyses of MRI features were conducted to identify the potential predictors of an NPVr ≥90%. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1516301DOI Listing
October 2018
3 Reads

High intensity focused ultrasound treatment of adenomyosis: a comparative study.

Int J Hyperthermia 2018 11;35(1):505-509. Epub 2018 Oct 11.

a Department of Gynecology , The First Hospital of Shijiazhuang , Shijiazhuang , China.

Objective: To compare the treatment efficacy and safety of high intensity focused ultrasound (HIFU) on its own, HIFU combined with levonorgestrel-releasing intrauterine system (LNG-IUS) and HIFU combined with gonadotropin-releasing hormone agonist (GnRHa).

Method: Seventy-eight patients with adenomyosis who underwent HIFU treatment were retrospectively analyzed. Among them, 45 patients were treated only with HIFU, 15 patients were treated with HIFU combined with LNG-IUS and 18 patients were treated with HIFU combined with GnRHa. Read More

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http://dx.doi.org/10.1080/02656736.2018.1509238DOI Listing
October 2018
3 Reads
2.645 Impact Factor

A molecular dynamics approach towards evaluating osmotic and thermal stress in the extracellular environment.

Int J Hyperthermia 2018 10;35(1):559-567. Epub 2018 Oct 10.

b Department of Interventional Radiology , M. D. Anderson Cancer Center, The University of Texas, Houston , TX , USA.

Objective: A molecular dynamics approach to understanding fundamental mechanisms of combined thermal and osmotic stress induced by thermochemical ablation (TCA) is presented.

Methods: Structural models of fibronectin and fibronectin bound to its integrin receptor provide idealized models for the effects of thermal and osmotic stress in the extracellular matrix. Fibronectin binding to integrin is known to facilitate cell survival. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1512161DOI Listing
October 2018
4 Reads