2,534 results match your criteria International Journal of Hyperthermia [Journal]


Heat risks associated with synthetic athletic fields.

Authors:
John Abraham

Int J Hyperthermia 2019 Apr 24:1-2. Epub 2019 Apr 24.

a University of St. Thomas , USA.

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http://dx.doi.org/10.1080/02656736.2019.1605096DOI Listing

Targeting autophagy enhances heat stress-induced apoptosis via the ATP-AMPK-mTOR axis for hepatocellular carcinoma.

Int J Hyperthermia 2019 22;36(1):499-510. Epub 2019 Apr 22.

a Institute of Hepatobiliary Surgery, Southwest Hospital , Third Military Medical University (Army Medical University) , Chongqing , P.R. China.

Purpose: Radiofrequency ablation (RFA) is widely accepted as a curative treatment for small hepatocellular carcinoma (HCC). However, insufficient RFA (IRFA) can lead to rapid local recurrence. The underlying mechanisms remain poorly understood. Read More

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http://dx.doi.org/10.1080/02656736.2019.1600052DOI Listing

Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis.

Int J Hyperthermia 2019 17;36(1):486-492. Epub 2019 Apr 17.

a Department of Gynecology, Shanghai First Maternity and Infant Hospital , Tongji University School of Medicine , Shanghai , PR China.

Objective: To evaluate the combined efficacy of high-intensity focused ultrasound (HIFU), gonadotropin-releasing hormone agonist (GnRH-a) and the levonorgestrel-releasing intrauterine system (LNG-IUS) for the treatment of severe adenomyosis.

Method: Four hundred and sixty-six patients with adenomyosis admitted to the Department of Gynecology of Shanghai First Maternity and Infant Hospital underwent HIFU treatment, and then were consecutively administered with GnRH-a 1 d, 1 month and 3 months after HIFU treatment. The uterine size was then measured with ultrasound or MRI 2-4 weeks after three cycles of GnRH-a injection. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2019.1
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http://dx.doi.org/10.1080/02656736.2019.1595179DOI Listing
April 2019
5 Reads

BRAF status as a predictive factor for response in isolated limb perfusion.

Int J Hyperthermia 2019 Apr 15:1-5. Epub 2019 Apr 15.

a Department of Surgery , Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden.

Background: Isolated limb perfusion (ILP) is a treatment option for unresectable in-transit melanoma metastases of the extremities. Approximately two-thirds of the patients have a complete response, and known predictive factors mainly regard tumor burden. In an attempt to identify subgroups with higher response rates, we retrospectively analyzed the predictive value of the BRAF V600E/K mutation for response at our institution. Read More

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http://dx.doi.org/10.1080/02656736.2019.1601778DOI Listing
April 2019
2 Reads

Predictive value of SAR based quality indicators for head and neck hyperthermia treatment quality.

Int J Hyperthermia 2019 11;36(1):456-465. Epub 2019 Apr 11.

b Department of Radiation Oncology, Erasmus Medical Center , Hyperthermia Unit , Rotterdam , The Netherlands.

Purpose: Hyperthermia treatment quality determines treatment effectiveness as shown by the clinically derived thermal-dose effect relations. SAR based optimization factors are used as possible surrogate for temperature, since they are not affected by thermal tissue properties uncertainty and variations. Previously, target coverage (TC) at the 25% and 50% iso-SAR level was shown predictive for treatment outcome in superficial hyperthermia and the target-to-hot-spot-quotient (THQ) was shown to highly correlate with predictive temperature in deep pelvic hyperthermia. Read More

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http://dx.doi.org/10.1080/02656736.2019.1590652DOI Listing

Real-time monitoring radiofrequency ablation using tree-based ensemble learning models.

Int J Hyperthermia 2019 2;36(1):428-437. Epub 2019 Apr 2.

a Department of Electrical and Computer Engineering , Northwestern University , Evanston , IL , USA.

Background: Radiofrequency ablation is a minimally-invasive treatment method that aims to destroy undesired tissue by exposing it to alternating current in the 100 kHz-800 kHz frequency range and heating it until it is destroyed via coagulative necrosis. Ablation treatment is gaining momentum especially in cancer research, where the undesired tissue is a malignant tumor. While ablating the tumor with an electrode or catheter is an easy task, real-time monitoring the ablation process is a must in order to maintain the reliability of the treatment. Read More

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http://dx.doi.org/10.1080/02656736.2019.1587008DOI Listing
April 2019
4 Reads

Assessment of nephrotoxicity associated with combined cisplatin and mitomycin C usage in laparoscopic hyperthermic intraperitoneal chemotherapy.

Int J Hyperthermia 2019 1;36(1):493-498. Epub 2019 Apr 1.

b Department of Surgical Oncology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.

Background: Laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) has been used to treat various peritoneal malignancies. Cisplatin and mitomycin C (MMC) are agents commonly used in these procedures and, individually, each has been associated with acute kidney injury (AKI). There is limited literature on the complications associated with the use of both agents in HIPEC. Read More

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http://dx.doi.org/10.1080/02656736.2019.1597175DOI Listing
April 2019
2 Reads

Feasibility study of metabolically supported chemotherapy with weekly carboplatin/paclitaxel combined with ketogenic diet, hyperthermia and hyperbaric oxygen therapy in metastatic non-small cell lung cancer.

Int J Hyperthermia 2019 1;36(1):446-455. Epub 2019 Apr 1.

a Department of Medical Oncology , School of Medicine, Altinbas University , Istanbul , Turkey.

Background: Previous evidence suggests that metabolically supported chemotherapy (MSCT), ketogenic diet, hyperthermia and hyperbaric oxygen therapy (HBOT) could all target vulnerabilities of cancer cells. This study aimed to evaluate the efficacy and the tolerability of this combination therapy in the treatment of stage IV non-small cell lung cancer (NSCLC).

Methods: Forty-four NSCLC patients with distant metastasis that received MSCT (administration of chemotherapy regimen following induced hypoglycemia) plus ketogenic diet, hyperthermia and HBOT combination were included in this retrospective study. Read More

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http://dx.doi.org/10.1080/02656736.2019.1589584DOI Listing
April 2019
2 Reads

Reactivation of heat-inactivated Ku proteins by heat shock cognate protein HSC73.

Int J Hyperthermia 2019 28;36(1):438-443. Epub 2019 Mar 28.

c Laboratory of Cell and Stress Biology, College of Bioscience and Biotechnology , Chubu University , Kasugai , Japan.

Purpose: Mouse double-stranded DNA-dependent protein kinase (DNA-PK) activity is heat sensitive. Recovery of heat-inactivated DNA repair activity is a problem after combination therapy with radiation and heat. We investigated the mechanism of recovery of heat-inactivated DNA-PK activity. Read More

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http://dx.doi.org/10.1080/02656736.2019.1587009DOI Listing

Correction.

Authors:

Int J Hyperthermia 2019 28;36(1):485. Epub 2019 Mar 28.

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http://dx.doi.org/10.1080/02656736.2019.1594057DOI Listing

Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study.

Int J Hyperthermia 2019 28;36(1):466-472. Epub 2019 Mar 28.

a Medical Laser Center Lübeck , Lübeck , Germany.

Objective/Purpose: In order to study the effects of hyperthermia and other temperature-related effects on cells and tissues, determining the precise time/temperature course is crucial. Here we present a non-contact optoacoustic technique, which provides temperatures during heating of cultured cells with scalable temporal and spatial resolution.

Methods: A thulium laser (1. Read More

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http://dx.doi.org/10.1080/02656736.2019.1590653DOI Listing
March 2019
1 Read

The impact of technical parameters on ablation volume during MR-guided focused ultrasound of desmoid tumors.

Int J Hyperthermia 2019 28;36(1):473-476. Epub 2019 Mar 28.

b Department of Epidemiology and Biostatistics , University of California, San Francisco , San Francisco , CA , USA.

Purpose: Desmoid tumors are benign, locally aggressive soft tissue tumors derived from fibroblasts. Magnetic resonance-guided focused ultrasound (MRgFUS) is a safe and effective treatment for desmoid tumors. The purpose of this study was to retrospectively review the MRgFUS treatments of desmoid tumors at our institution to determine which technical treatment parameters contributed most significantly to the accumulation of thermal dose. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2019.1
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http://dx.doi.org/10.1080/02656736.2019.1590654DOI Listing
March 2019
1 Read

Modified-FOLFIRINOX combined with deep regional hyperthermia in pancreatic cancer: a retrospective study in Chinese patients.

Int J Hyperthermia 2019 27;36(1):394-402. Epub 2019 Mar 27.

a Department of Oncology , Second Affiliated Hospital of Dalian Medical University , Dalian , PR China.

Background: FOLFIRINOX chemotherapy displays significant survival improvements in patients with pancreatic cancer. However, toxicities have hampered enthusiasm for the use of FOLFIRINOX in full dose. In order to increase the tolerability, many researchers focused on the modification of FOLFIRINOX. Read More

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http://dx.doi.org/10.1080/02656736.2019.1579371DOI Listing
March 2019
2 Reads
2.645 Impact Factor

Reasons for different therapeutic effects of high-intensity focused ultrasound ablation on excised uterine fibroids with different signal intensities on T2-weighted MRI: a study of histopathological characteristics.

Int J Hyperthermia 2019 27;36(1):477-484. Epub 2019 Mar 27.

a State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Biomedical Engineering, College of Biomedical Engineering , Chongqing Medical University , Chongqing , PR China.

Objective: The objective of this study was to explore the correlations between the therapeutic effect of high intensity focused ultrasound (HIFU) and histopathological characteristics of excised uterine fibroids with different signal intensities as visualized on T2-weighted magnetic resonance imaging (MRI).

Methods: We collected 47 specimens of uterine fibroids after surgical resection and classified them into four groups according to preoperative T2-weighted MRI hypo-intense, isointense, heterogeneous intense and homogeneous hyper-intense. Then, specimens in each group were irradiated by HIFU with the same parameters and the necrotic tissue volume was calculated. Read More

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http://dx.doi.org/10.1080/02656736.2019.1592242DOI Listing
March 2019
1 Read

Letter to the editor regarding perivascular extension of microwave ablation zone.

Int J Hyperthermia 2019 26;36(1):444. Epub 2019 Mar 26.

a Department of Breast Surgery , The First Affiliated Hospital with Nanjing Medical University , Nanjing , 210029 , China.

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http://dx.doi.org/10.1080/02656736.2019.1587010DOI Listing

Minimally-invasive treatments for benign thyroid nodules: a Delphi-based consensus statement from the Italian minimally-invasive treatments of the thyroid (MITT) group.

Int J Hyperthermia 2019 26;36(1):376-382. Epub 2019 Mar 26.

aa Division of Interventional Radiology , IEO, European Institute of Oncology IRCCS , Milan , Italy.

Benign thyroid nodules are a common clinical occurrence and usually do not require treatment unless symptomatic. During the last years, ultrasound-guided minimally invasive treatments (MIT) gained an increasing role in the management of nodules causing local symptoms. In February 2018, the Italian MIT Thyroid Group was founded to create a permanent cooperation between Italian and international physicians dedicated to clinical research and assistance on MIT for thyroid nodules. Read More

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http://dx.doi.org/10.1080/02656736.2019.1575482DOI Listing
March 2019
1 Read

Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses.

Int J Hyperthermia 2019 26;36(1):383-393. Epub 2019 Mar 26.

a Graduate School, China Medical University , Shenyang , China.

Background: Hyperthermia has proved successful in treating cutaneous human papillomavirus infectious diseases such as plantar wart and condyloma acuminata (CA). Moreover, this treatment provides improved therapeutic efficacy in these conditions as compared with conventional therapies.

Objectives: To investigate the global proteome changes in CA in response to hyperthermia and achieve a better understanding of the mechanisms of hyperthermia therapy against HPV-infectious diseases. Read More

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http://dx.doi.org/10.1080/02656736.2019.1578420DOI Listing
March 2019
1 Read

In response to letter to the editor from Ma et al. 2019 regarding perivascular extension of microwave ablation zone.

Int J Hyperthermia 2019 23;36(1):445. Epub 2019 Mar 23.

b Department of Surgery, Hepatopancreatobiliary and Liver Transplant Surgery Unit, Royal Free Hospital , University College London , London , UK.

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https://www.tandfonline.com/doi/full/10.1080/02656736.2019.1
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http://dx.doi.org/10.1080/02656736.2019.1587011DOI Listing
March 2019
2 Reads

High-intensity focused ultrasound combined procedures treatment of retained placenta accreta with marked vascularity after abortion or delivery.

Int J Hyperthermia 2019 20;36(1):421-427. Epub 2019 Mar 20.

b Department of Pathology , West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University , Chengdu , China.

Objective: To evaluate the safety and feasibility of combined procedures: HIFU combined with systemic MTX followed by ultrasound-guided curettage or hysteroscopic resection while treating placenta accreta (PA).

Method: This study included 21 patients diagnosed with retained PA with marked vascularity after abortion or delivery from July 2015 to December 2017. Patients with high serum β-hCG level (≥100 mIU/mL) received systemic MTX + HIFU treatment for 3 days and the ones with low β-hCG level (<100 mIU/mL) only received USgHIFU treatment for 3 days before ultrasound-guided curettage or hysteroscopic resection. Read More

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http://dx.doi.org/10.1080/02656736.2019.1581279DOI Listing
March 2019
1 Read

Cryo-thermal therapy inducing MI macrophage polarization created CXCL10 and IL-6-rich pro-inflammatory environment for CD4 T cell-mediated anti-tumor immunity.

Int J Hyperthermia 2019 20;36(1):408-420. Epub 2019 Mar 20.

a School of Biomedical Engineering and Med-X Research Institute , Shanghai Jiao Tong University , Shanghai , PR China.

Purpose: We previously developed a novel cryo-thermal therapy to treat malignant mammary carcinoma and melanoma in a mouse model; long-term survival and CD4 T cell orchestrating anti-tumor immune memory response were achieved. Moreover, cryo-thermal-induced CD4 T cell differentiation into Th1 and CD4CTL sub-lineages, in which M1 macrophage polarization played a direct, important role. In particular, cryo-thermal therapy triggered M1 macrophage polarization with up-regulated expression of C-X-C motif ligand 10 (CXCL10) and Interleukin 6 (IL-6). Read More

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http://dx.doi.org/10.1080/02656736.2019.1579373DOI Listing

Ultrasound-guided percutaneous microwave ablation versus surgical resection for recurrent intrahepatic cholangiocarcinoma: intermediate-term results.

Int J Hyperthermia 2019 8;36(1):351-358. Epub 2019 Mar 8.

e Department of Hepatobiliary Surgery , The Second Hospital of Nanjing Nanjing University of Chinese Medicine , Nanjing , China.

Objective: The aims of this study were to compare the clinical outcomes between ultrasound-guided percutaneous microwave ablation (US-PMWA) and surgical resection (SR) in patients with recurrent intrahepatic cholangiocarcinoma (ICC) and to identify the prognostic factors associated with the two treatment methods.

Methods: This retrospective study was institutional review board approved. A total of 121 patients (102 men and 19 women) with 136 ICCs after hepatectomy from April 2011 to January 2017 were reviewed. Read More

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http://dx.doi.org/10.1080/02656736.2019.1571247DOI Listing
March 2019
2 Reads
2.645 Impact Factor

Microwave ablation of hyperplastic parathyroid glands is a treatment option for end-stage renal disease patients ineligible for surgical resection.

Int J Hyperthermia 2019 ;36(1):29-35

b Department of Interventional Ultrasound , China-Japan Friendship Hospital , Beijing , People's Republic of China.

Background: Secondary hyperparathyroidism (SHPT) is a frequently encountered problem in patients with end-stage renal disease (ESRD). Some patients with severe SHPT could not be managed by medical treatment and are ineligible for surgical resection.

Purpose: Our objective was to evaluate the efficacy, safety of microwave ablation (MWA) on these patients. Read More

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http://dx.doi.org/10.1080/02656736.2018.1528392DOI Listing
January 2019
2 Reads
2.645 Impact Factor

Comparison of efficacy and complications between radiofrequency ablation and repeat surgery in the treatment of locally recurrent thyroid cancers: a single-center propensity score matching study.

Int J Hyperthermia 2019 5;36(1):359-367. Epub 2019 Mar 5.

a Department of Radiology , The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital , Seoul , Korea.

Purpose: To compare the efficacy and complication rates of radiofrequency ablation (RFA) and repeat surgery in the treatment of locally recurrent thyroid cancers.

Materials And Methods: A total of 221 patients with locally recurrent thyroid cancers who underwent either RFA (n = 96) or repeat surgery (n = 125) between March 2008 and March 2017 were retrospectively enrolled (range of follow-up, 1-10 years). Each cohort consisted of 70 patients after propensity score adjustment. Read More

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http://dx.doi.org/10.1080/02656736.2019.1571248DOI Listing
March 2019
5 Reads
2.645 Impact Factor

Comparison of temperature change and resulting ablation size induced by a 902-928 MHz and a 2450 MHz microwave ablation system in in-vivo porcine kidneys.

Int J Hyperthermia 2019 5;36(1):313-321. Epub 2019 Mar 5.

a Joint Bioengineering and Endourology Developmental Surgical Laboratory, Division of Endourology, Laparoscopy, and Minimally-Invasive Surgery, Department of Urology , University of Miami Miller School of Medicine , Miami , FL , USA.

Introduction: Microwave ablation (MWA) uses heat to ablate undesired tissue. Development of pre-planning algorithms for MWA of small renal masses requires understanding of microwave-tissue interactions at different operating parameters. The objective of this study was to compare the performance of two MWA systems in in-vivo porcine kidneys. Read More

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http://dx.doi.org/10.1080/02656736.2019.1565788DOI Listing
March 2019
6 Reads

Intraperitoneal perfusion chemotherapy and whole abdominal hyperthermia using external radiofrequency following radical D2 resection for treatment of advanced gastric cancer.

Int J Hyperthermia 2019 4;36(1):403-407. Epub 2019 Mar 4.

b Department of Oncology, Affiliated Hangzhou First People's Hospital , Zhejiang University School of Medicine , Hangzhou , PR China.

Background: The peritoneum is the most frequent site of disease recurrence in gastric cancer, and the prognosis remains poor. This study assessed the role of adjuvant intraperitoneal (IP) chemotherapy with whole abdominal hyperthermia using external radiofrequency in gastric cancer patients after D2 dissection.

Methods: Patients with gastric cancer who underwent gastrectomy with D2 regional lymph node dissection were enrolled in the study. Read More

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http://dx.doi.org/10.1080/02656736.2019.1579372DOI Listing
March 2019
3 Reads

An assessment of the survival impact of multimodal anesthesia/analgesia technique in adults undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a propensity score matched analysis.

Int J Hyperthermia 2019 4;36(1):369-375. Epub 2019 Mar 4.

a Department of Anesthesiology and Perioperative Medicine , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.

Background: Studies suggest volatile anesthetics and opioids may enhance the malignant potential of cancer cells. The objective of this single institution retrospective study was to evaluate the survival impact of a multimodal opioid-sparing nonvolatile anesthetic technique (MA) in a group of patients who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for appendiceal carcinomatosis.

Methods: Propensity score matching (PSM) and Cox proportional hazard models were used to compare the survivals of patients who received MA (MA group), to those who received volatile-opioid anesthesia (volatile-opioid group). Read More

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http://dx.doi.org/10.1080/02656736.2019.1574985DOI Listing

Regional deep hyperthermia: quantitative evaluation of predicted and direct measured temperature distributions in patients with high-risk extremity soft-tissue sarcoma.

Int J Hyperthermia 2019 19;36(1):170-185. Epub 2019 Feb 19.

a Department of Internal Medicine III , Ludwig Maximilians University Hospital , Munich , Germany.

Background: Temperature distributions resulting from hyperthermia treatment of patients with high-risk soft-tissue sarcoma (STS) were quantitatively evaluated and globally compared with thermal simulations performed by a treatment planning system. The aim was to test whether the treatment planning system was able to predict correct temperature distributions.

Methods: Five patients underwent computed tomography (CT) fluoroscopy-guided placement of tumor catheters used for the interstitial temperature measurements. Read More

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http://dx.doi.org/10.1080/02656736.2018.1545098DOI Listing
February 2019

Correction.

Authors:

Int J Hyperthermia 2019 19;36(1):368. Epub 2019 Feb 19.

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http://dx.doi.org/10.1080/02656736.2019.1572925DOI Listing
February 2019
1 Read

Safety and technical feasibility of percutaneous ablation for lymph node metastases of hepatocellular carcinoma.

Int J Hyperthermia 2019 Jan 19;36(1):160-168. Epub 2019 Feb 19.

a Center of Interventional Oncology and Liver Diseases , Beijing You'an Hospital, Capital Medical University , Beijing , China.

Purpose: This study aimed to assess the safety and technical feasibility of percutaneous ablation therapy for lymph node (LN) metastases of hepatocellular carcinoma (HCC).

Material And Methods: A total of 31 consecutive HCC patients with LN metastases who were treated with ablation were included in this retrospective study. Percutaneous ablation was performed under local anesthesia and computed tomography-guidance. Read More

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http://dx.doi.org/10.1080/02656736.2018.1542510DOI Listing
January 2019
2 Reads
2.645 Impact Factor

Orthotopic hepatocellular carcinoma: molecular imaging-monitored intratumoral hyperthermia-enhanced direct oncolytic virotherapy.

Int J Hyperthermia 2019 18;36(1):344-350. Epub 2019 Feb 18.

a Image-Guided Bio-Molecular Interventions Section, Division of Interventional Radiology, Department of Radiology , University of Washington School of Medicine , Seattle , WA , USA.

Objective: To validate the feasibility of molecular imaging-monitored intratumoral radiofrequency hyperthermia (RFH) enhanced direct oncolytic virotherapy for hepatocellular carcinoma (HCC).

Methods: This study included in vitro experiments using luciferase-labeled rat HCC cells and in vivo validation experiments on rat models with orthotopic HCCs. Both cells and HCCs in four groups (n = 6/group) were treated by: (1) combination therapy of oncolytic virotherapy (T-VEC) plus RFH at 42 °C for 30 min; (2) oncolytic virotherapy alone; (3) RFH alone; and (4) saline. Read More

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http://dx.doi.org/10.1080/02656736.2019.1569731DOI Listing
February 2019
1 Read

Biofunctionalization of magnetite nanoparticles with stevioside: effect on the size and thermal behaviour for use in hyperthermia applications.

Int J Hyperthermia 2019 7;36(1):302-312. Epub 2019 Feb 7.

a Institute of Nano Science and Technology , Mohali , Punjab , India.

Controlling the magnetic properties of a nanoparticle efficiently via its particle size to achieve optimized heat under alternating magnetic field is the central point for magnetic hyperthermia-mediated cancer therapy (MHCT). Here, we have shown the successful use of stevioside (a natural plant-based glycoside) as a promising biosurfactant to control the magnetic properties of FeO nanoparticles by controlling the particle size. The biocompatibility and cellular uptake efficiency by rat C6 glioma cells and calorimetric magnetic hyperthermia profile of the nanoparticles were further examined. Read More

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http://dx.doi.org/10.1080/02656736.2019.1565787DOI Listing
February 2019

A novel software platform for volumetric assessment of ablation completeness.

Int J Hyperthermia 2019 7;36(1):337-343. Epub 2019 Feb 7.

b Department of Biomedical Sciences , Humanitas University , Rozzano , Milan , Italy.

Purpose: To retrospectively evaluate the accuracy of a novel software platform for assessing completeness of percutaneous thermal ablations.

Materials & Methods: Ninety hepatocellular carcinomas (HCCs) in 50 patients receiving percutaneous ultrasound-guided microwave ablation (MWA) that resulted in apparent technical success at 24-h post-ablation computed tomography (CT) and with ≥1-year imaging follow-up were randomly selected from a 320 HCC ablation database (2010-2016). Using a novel volumetric registration software, pre-ablation CT volumes of the HCCs without and with the addition of a 5 mm safety margin, and corresponding post-ablation necrosis volumes were segmented, co-registered and overlapped. Read More

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http://dx.doi.org/10.1080/02656736.2019.1569267DOI Listing
February 2019
1 Read

Radiofrequency endometrial ablation for treating heavy menstrual bleeding in women with chronic renal failure.

Int J Hyperthermia 2018 1;35(1):612-616. Epub 2018 Nov 1.

a Department of Obstetrics and Gynecology , The Third Xiangya Hospital of Central South University , Changsha , China.

Objective: The study objective was to retrospectively evaluate the efficacy and safety of radiofrequency endometrial ablation in treating heavy menstrual bleeding (HMB) in women with chronic renal failure (CRF).

Method: Fifty-eight patients with CRF undergoing radiofrequency endometrial ablation in our hospital between January 2013 and July 2017 and for whom complete follow-up data were available were included. Outcome measures included amenorrhea, treatment failure and operative complications. Read More

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http://dx.doi.org/10.1080/02656736.2018.1515445DOI Listing
November 2018
1 Read

Activated hepatic stellate cells promote progression of post-heat residual hepatocellular carcinoma from autophagic survival to proliferation.

Int J Hyperthermia 2019 31;36(1):253-263. Epub 2019 Jan 31.

a Zhongshan Hospital Fudan University and Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education, Liver Cancer Institute , Shanghai , China.

Background: Microscopic residual tumor often occurs after thermal ablation for medium-large hepatocellular carcinoma (HCC), leading to early aggressive recurrence or late relapse during follow-up. The mechanism how microscopic residual HCC cells survive sublethal heat stress and develop rapid outgrowth remains poorly understood.

Methods: HCC cells were exposed to sublethal heat treatment and co-cultured with conditioned media from activated HSCs (HSC-CM). Read More

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http://dx.doi.org/10.1080/02656736.2018.1558459DOI Listing
January 2019
4 Reads

'Relationship between thermal dose and cell death for "rapid" ablative and "slow" hyperthermic heating'.

Int J Hyperthermia 2019 31;36(1):229-243. Epub 2019 Jan 31.

a Joint Department of Physics, Division of Radiotherapy and Imaging , The Institute of Cancer Research: Royal Marsden Hospital , Sutton , UK.

Aim: Thermal isoeffective dose (TID) has not been convincingly validated for application to predict biological effects from rapid thermal ablation (e.g., using >55 °C). Read More

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http://dx.doi.org/10.1080/02656736.2018.1558289DOI Listing
January 2019
5 Reads

Predictive value of the albumin-bilirubin grade on long-term outcomes of CT-guided percutaneous microwave ablation in intrahepatic cholangiocarcinoma.

Int J Hyperthermia 2019 28;36(1):328-336. Epub 2019 Jan 28.

a Department of Minimally Invasive Interventional Radiology , Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Cancer for Cancer Medicine , Guangzhou , PR China.

Purpose: To assess the efficacy of the albumin-bilirubin (ALBI) grade on assessing long-term outcomes of computed tomography (CT)-guided percutaneous microwave ablation (CT-PMWA) in the treatment of patients with intrahepatic cholangiocarcinoma (ICC).

Methods: Between April 2011 and March 2018, 78 patients who underwent CT-PMWA were enrolled in this study. Overall survival (OS) and recurrence-free survival (RFS) were compared in the groups stratified by the ALBI grade and Child-Pugh score. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2019.1
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http://dx.doi.org/10.1080/02656736.2019.1567834DOI Listing
January 2019
6 Reads

US-guided microwave ablation for secondary hyperparathyroidism in patients after renal transplantation: a pilot study.

Int J Hyperthermia 2019 24;36(1):322-327. Epub 2019 Jan 24.

b Interventional Ultrasound Center , China-Japan Friendship Hospital , Beijing , China.

Objective: To assess the safety and efficacy of ultrasound-guided microwave ablation (MWA) in the treatment of patients who develop secondary hyperparathyroidism (SHPT) after renal transplantation (RT).

Methods: In total, nine patients, each with symptomatic SHPT caused by RT and at least one enlarged parathyroid gland, underwent MWA via hydrodissection. Intact parathyroid hormone (i-PTH), serum calcium, serum phosphorus, creatinine and blood urea nitrogen concentrations, before and after MWA, were assessed and compared. Read More

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http://dx.doi.org/10.1080/02656736.2019.1566580DOI Listing
January 2019
2 Reads

Engineering T cell response to cancer antigens by choice of focal therapeutic conditions.

Int J Hyperthermia 2019 24;36(1):130-138. Epub 2019 Jan 24.

a Department of Mechanical Engineering , University of Minnesota , Minneapolis , MN , USA.

Focal thermal therapy (Heat), cryosurgery (Cryo) and irreversible electroporation (IRE) are increasingly used to treat cancer. However, local recurrence and systemic spread are persistent negative outcomes. Nevertheless, emerging work with immunotherapies (i. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1539253DOI Listing
January 2019
7 Reads

The treatment of cervical pregnancy with high-intensity focused ultrasound followed by suction curettage: report of three cases.

Int J Hyperthermia 2019 24;36(1):273-276. Epub 2019 Jan 24.

a Department of Obstetrics and Gynecology , The Third Xiangya Hospital of Central South University , Changsha , Hunan Province , China.

Objective: Cervical pregnancy (CP) is a rare type of ectopic pregnancy and is considered to be a life-threatening condition due to the risk of severe hemorrhage. Unfortunately, no consensus on standard conservative treatment for CP has been established. The study objective was to evaluate the efficacy and safety of high-intensity focused ultrasound (HIFU) followed by suction curettage for cervical pregnancy. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1563914DOI Listing
January 2019
11 Reads

Quality assurance guidelines for interstitial hyperthermia.

Int J Hyperthermia 2019 24;36(1):277-294. Epub 2019 Jan 24.

d Department of Radiation Oncology, Cancer Center Amsterdam , Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands.

Quality assurance (QA) guidelines are essential to provide uniform execution of clinical hyperthermia treatments and trials. This document outlines the clinical and technical consequences of the specific properties of interstitial heat delivery and specifies recommendations for hyperthermia administration with interstitial techniques. Interstitial hyperthermia aims at tumor temperatures in the 40-44 °C range as an adjunct to radiation or chemotherapy. Read More

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http://dx.doi.org/10.1080/02656736.2018.1564155DOI Listing
January 2019

Comparison of microwave ablation and radiofrequency ablation for hepatocellular carcinoma: a systematic review and meta-analysis.

Int J Hyperthermia 2019 24;36(1):264-272. Epub 2019 Jan 24.

a Department of Endoscopy , Sun Yat-sen University Cancer Center , Guangzhou , China.

Background: Microwave ablation (MWA) has several advantages over radiofrequency ablation (RFA) for the treatment of hepatocellular carcinoma (HCC). We aimed to compare the efficacy and safety of MWA with those of RFA for HCC from the perspectives of percutaneous and laparoscopic approaches.

Methods: PubMed/MEDLINE, Embase, the Cochrane library, and China Biology Medicine databases were searched. Read More

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http://dx.doi.org/10.1080/02656736.2018.1562571DOI Listing
January 2019
1 Read

Nonresective treatments for uterine fibroids: a systematic review of uterine and fibroid volume reductions.

Int J Hyperthermia 2019 24;36(1):295-301. Epub 2019 Jan 24.

a Department of Gynaecology , St Mary's Hospital, Imperial College Healthcare Trust , London , UK.

Patients are increasingly seeking uterus-preserving, minimally invasive treatments for symptomatic uterine fibroids. This has led to a greater use of nonresective treatments such as uterine artery embolization (UAE), focused ultrasound (FUS) and more recently, radiofrequency ablation (RFA) of fibroids. This systematic review, following PRISMA guidelines, examines the change in uterine and fibroid volumes associated with UAE, FUS, and RFA. Read More

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http://dx.doi.org/10.1080/02656736.2018.1564843DOI Listing
January 2019
1 Read

Efficacy and safety of high-intensity focused ultrasound ablation for hepatocellular carcinoma by changing the acoustic environment: microbubble contrast agent (SonoVue) and transcatheter arterial chemoembolization.

Int J Hyperthermia 2019 22;36(1):244-252. Epub 2019 Jan 22.

b Clinical Center for Tumor Therapy of the Second Affiliated Hospital of Chongqing Medical University , Chongqing , China.

Objective: To compare efficacy and safety of microbubble contrast agent (SonoVue) and transcatheter arterial chemoembolization (TACE) in combination with high-intensity focused ultrasound (HIFU) for treatment of patients with hepatocellular carcinoma (HCC).

Methods: According to our inclusion criteria, we retrospectively reviewed 52 patients with HCCs, and divided them into SonoVue group and TACE group. Tumors were examined by enhanced magnetic resonance imaging. Read More

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http://dx.doi.org/10.1080/02656736.2018.1558290DOI Listing
January 2019
1 Read

Efficacy of cryoablation combined with sorafenib for the treatment of advanced renal cell carcinoma.

Int J Hyperthermia 2019 21;36(1):220-228. Epub 2019 Jan 21.

a Department of Interventional Treatment , Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer , Tianjin , China.

Objective: To determine the safety and efficacy of cryoablation combined with sorafenib for the treatment of advanced renal cell carcinoma.

Material And Methods: We conducted an observational study in 156 patients with advanced renal cell carcinoma unsuitable for surgical treatment. Participants received cryoablation + sorafenib (n = 67) or sorafenib only (n = 89). Read More

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http://dx.doi.org/10.1080/02656736.2018.1556819DOI Listing
January 2019
2 Reads

The value of KRAS gene status in predicting local tumor progression of colorectal liver metastases following radiofrequency ablation.

Int J Hyperthermia 2019 Jan 21;36(1):211-219. Epub 2019 Jan 21.

a Department of Ultrasound, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) , Peking University Cancer Hospital and Institute , Beijing , China.

Purpose: We investigated the relationships between KRAS gene status and local tumor progression (LTP) of colorectal liver metastases (CLMs) after treatment with percutaneous ultrasound-guided radiofrequency ablation (RFA).

Materials And Methods: Clinical and imaging data from 76 patients (154 lesions) with CLM who underwent percutaneous ultrasound-guided RFA and had KRAS gene test results between January 2012 and June 2016 were analyzed. The average lesion size was 2. Read More

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http://dx.doi.org/10.1080/02656736.2018.1556818DOI Listing
January 2019
8 Reads

Management strategy for nerve damage during radiofrequency ablation of thyroid nodules.

Int J Hyperthermia 2019 14;36(1):204-210. Epub 2019 Jan 14.

a Department of Radiology and the Research Institute of Radiology, Asan Medical Center , University of Ulsan College of Medicine , Seoul , Korea.

Objective: The aim of this study was to introduce a management strategy for nerve damage occurring during radiofrequency ablation (RFA).

Methods: From January 2016 to October 2017, 17 patients who experienced the symptoms of nerve damage during RFA were enrolled in this study. If damage to nerves was suspected during RFA, ablation was stopped immediately, and a cold solution of 5% dextrose was injected directly into the space where the nerves were located until symptoms improved. Read More

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http://dx.doi.org/10.1080/02656736.2018.1554826DOI Listing
January 2019
2 Reads

High intensity focused ultrasound (HIFU) ablation of benign thyroid nodule is safe and efficacious in patients who continue taking an anti-coagulation or anti-platelet agent in the treatment period.

Int J Hyperthermia 2019 16;36(1):186-190. Epub 2018 Dec 16.

c Department of Radiology , The University of Hong Kong , Hong Kong , China.

Background: High intensity focused ultrasound (HIFU) ablation is a promising treatment for benign thyroid nodules but because bleeding complications can occur following any intervention to the thyroid gland, the safety and efficacy of HIFU ablation were evaluated in patients who continued taking an anti-coagulation or anti-platelet agent during treatment.

Methods: From 2015 to 2017, 303 patients who underwent a single-session ablation for a benign thyroid nodule were analyzed. The primary study endpoint was thyroid bleeding, intra-lesional or peri-thyroidal hematoma or neck bruising diagnosed within 4 days of the treatment. Read More

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http://dx.doi.org/10.1080/02656736.2018.1548034DOI Listing
December 2018
2 Reads

Quality of life and outcomes in patients with a large toxic adenoma undergoing laser ablation plus radioiodine vs lobectomy.

Int J Hyperthermia 2019 Dec 16;36(1):191-195. Epub 2018 Dec 16.

a Division of Endocrinology , "V. Fazzi" Hospital, Piazza F. Muratore , Lecce , Italy.

Purpose: Patients with toxic adenomas (TAs) that are too large to undergo radioactive iodine (RAI) treatment aimed at resolving hyperthyroidism and/or relieving mechanical pressure symptoms are referred to surgery. This prospective study aimed to assess the outcomes of combining laser ablation (LA) plus RAI vs lobectomy to treat large TAs in terms of clinical efficacy and the health-related quality of life (HRQoL).

Patients And Methods: Patients with TAs of volumes greater than 20 mL and a calculated therapeutic activity exceeding 600 Mbq were randomly assigned to undergo LA + RAI (Group A) or lobectomy (Group B). Read More

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http://dx.doi.org/10.1080/02656736.2018.1549335DOI Listing
December 2019
3 Reads

Temperature-controlled power modulation compensates for heterogeneous nanoparticle distributions: a computational optimization analysis for magnetic hyperthermia.

Int J Hyperthermia 2019 12;36(1):115-129. Epub 2018 Dec 12.

a Department of Mechanical Engineering, Whiting School of Engineering , Johns Hopkins University , Baltimore , MD , USA.

Purpose: To study, with computational models, the utility of power modulation to reduce tissue temperature heterogeneity for variable nanoparticle distributions in magnetic nanoparticle hyperthermia.

Methods: Tumour and surrounding tissue were modeled by elliptical two- and three-dimensional computational phantoms having six different nanoparticle distributions. Nanoparticles were modeled as point heat sources having amplitude-dependent loss power. Read More

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http://dx.doi.org/10.1080/02656736.2018.1538538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411438PMC
December 2018
1 Read

Longer heating duration increases localized doxorubicin deposition and therapeutic index in Vx2 tumors using MR-HIFU mild hyperthermia and thermosensitive liposomal doxorubicin.

Int J Hyperthermia 2019 12;36(1):196-203. Epub 2018 Dec 12.

a Department of Radiology , UT Southwestern Medical Center , Dallas , TX , USA.

Thermosensitive liposomal doxorubicin (LTSL-Dox) combined with mild hyperthermia enhances the localized delivery of doxorubicin (Dox) within a heated region. The optimal heating duration and the impact of extended heating on systemic drug distribution are unknown. Here we evaluated local and systemic Dox delivery with two different mild hyperthermia durations (42 °C for 10 or 40 minutes) in a Vx2 rabbit tumor model. Read More

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http://dx.doi.org/10.1080/02656736.2018.1550815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430695PMC
December 2018
2 Reads