508,689 results match your criteria International Journal of Health Research [Journal]


The treatment gap for mental disorders and associated factors in the Czech Republic.

Eur Psychiatry 2019 Apr 19;59:37-43. Epub 2019 Apr 19.

National Institute of Mental Health, Klecany, Czech Republic; Third Faculty of Medicine, Charles University Prague, Czech Republic. Electronic address:

Objectives: To assess the extent of the treatment gap for mental disorders in the Czech Republic, determine factors associated with the utilization of mental health services and explore what influences willingness to seek mental health care.

Methods: Data from the CZEch Mental health Study, a nationally representative study of community-dwelling adults in the Czech Republic were used. The Mini International Neuropsychiatric Interview assessed the presence of mental disorders. Read More

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http://dx.doi.org/10.1016/j.eurpsy.2019.04.003DOI Listing

CIDR estrous synchronization in the Arabian Oryx (Oryx leucoryx).

Theriogenology 2019 Apr 15;132:113-117. Epub 2019 Apr 15.

Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Egypt; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, King Faisal University, Saudi Arabia.

In Jordan, the Arabian Oryx (Oryx leucoryx) is considered among the most important wild ungulates. The Arabian Oryx is listed as vulnerable species according to the International Union for Conservation of Nature (IUCN). Based on author's knowledge, estrus synchronization in the Arabian Oryx has never been investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0093691X193009
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http://dx.doi.org/10.1016/j.theriogenology.2019.04.017DOI Listing
April 2019
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Synthesis and immunological studies of β-1,2-mannan-peptide conjugates as antifungal vaccines.

Eur J Med Chem 2019 Apr 5;173:250-260. Epub 2019 Apr 5.

Department of Chemistry, University of Florida, 214 Leigh Hall, Gainesville, FL, 32611, USA. Electronic address:

Fungal cell surface carbohydrates and proteins are useful antigens for the development of antifungal vaccines. In this study, glycopeptides consisting of the β-1,2-mannan and N-terminal peptide epitopes of Candida albicans (C. albicans) cell wall phosphomannan complex and Als1p (rAls1p-N) protein, respectively, were synthesized and covalently conjugated with keyhole limpet hemocyanin (KLH) and human serum albumin (HSA) through homobifunctional disuccinimidyl glutarate. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.001DOI Listing

Mechanical modeling of pimple growth.

J Mech Behav Biomed Mater 2019 Apr 16;95:191-195. Epub 2019 Apr 16.

Advanced Materials for Energy and Environment, Department of Earth and Environmental Engineering, Columbia University, New York, NY, 10027, USA; School of Chemical Engineering, Northwest University, Xi'an, 710069, PR China.

Pimple is one of the most common skin diseases for humans, whose growth cause pain yet the corresponding mechanical analysis is lacking. A finite element model is developed to quantify the deformation field with the expansion of follicle, and then the mechanical stimulus is related to the sensation of pain during the development of pimple. Parametric studies show the dependence of mechanical stimulus and pain level on the pimple-surrounded structures, follicle depth and mechanical properties of the epidermis. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.04.017DOI Listing

Degradation studies of Ibrutinib under stress conditions: Characterisation and structural elucidation of novel degradants.

J Pharm Biomed Anal 2019 Apr 12;172:9-17. Epub 2019 Apr 12.

Department of Engineering Chemistry, Andhra University, Visakhapatnam, A.P., 530003, India.

The aim of the research work is to study the degradation behaviour of Ibrutinib (IBN) which is performed under different stress conditions according to International Conference on Harmonization guidelines (ICH). The study included monitoring degradation of the Ibrutinib drug under acidic, base, oxidation, thermal and photolytic conditions followed by isolation and characterisation of degradation products (DP) by Liquid Chromatography Mass Spectrometry (LCMS), High resolution Mass Spectrometry (HR-MS/MS) and Nuclear Magnetic Resonance (NMR) studies. The IBN drug is stable under oxidation, thermal and photolytic conditions. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.04.010DOI Listing

The increasing lifespan variation gradient by area-level deprivation: A decomposition analysis of Scotland 1981-2011.

Soc Sci Med 2019 Apr 16;230:147-157. Epub 2019 Apr 16.

Max Planck Institute for Demographic Research, Rostock, Germany.

Life expectancy inequalities are an established indicator of health inequalities. More recent attention has been given to lifespan variation, which measures the amount of heterogeneity in age at death across all individuals in a population. International studies have documented diverging socioeconomic trends in lifespan variation using individual level measures of income, education and occupation. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.04.008DOI Listing

The risk of malignancy in uterine polyps: A systematic review and meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 15;237:48-56. Epub 2019 Apr 15.

Department of Woman, Newborn and Child, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, Università degli studi di Milano, Milan, Italy. Electronic address:

Background: Endometrial polyps are a common condition. The risk of malignancy has often led to an overtreatment with high health care costs and huge psychological distress.

Objective: We conducted a systematic review and a meta-analysis in order to estimate the prevalence of premalignant and malignant lesions in women undergoing hysteroscopic polypectomy. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.04.009DOI Listing

The value of manure - Manure as co-product in life cycle assessment.

J Environ Manage 2019 Apr 19;241:293-304. Epub 2019 Apr 19.

Innovation Center for U.S. Dairy, USA.

Livestock production is important for food security, nutrition, and landscape maintenance, but it is associated with several environmental impacts. To assess the risk and benefits arising from livestock production, transparent and robust indicators are required, such as those offered by life cycle assessment. A central question in such approaches is how environmental burden is allocated to livestock products and to manure that is re-used for agricultural production. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.03.059DOI Listing

Lung Cancer Risk in Never Smokers of European Descent is Associated with Genetic Variation in the 515.33 TERT-CLPTM1L Region.

J Thorac Oncol 2019 Apr 19. Epub 2019 Apr 19.

Geisel School of Medicine at Dartmouth, 1 Medical Center Dr, Lebanon, NH 03756, USA. Electronic address:

Introduction: Inherited susceptibility to lung cancer risk in never smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study (GWAS) on the largest, to date, set of European-descent never smokers with lung cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15560864193028
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http://dx.doi.org/10.1016/j.jtho.2019.04.008DOI Listing
April 2019
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Two paternal mosaicism of mutation in ELANE causing severe congenital neutropenia exhibit normal neutrophil morphology and ROS production.

Clin Immunol 2019 Apr 19. Epub 2019 Apr 19.

Chong Qing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Division of Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. Electronic address:

Severe congenital neutropenia caused by ELANE gene mutation is a rare disease. To date, only four families were reported with mosaicism. Here we examined the morphology and function of granulocytes isolated from two patients and their mosaic fathers. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.008DOI Listing

International and Multi-Institutional Assessment of Factors Associated with Performance and Quality of Lymph Node Dissection during Radical Nephrectomy.

Urology 2019 Apr 19. Epub 2019 Apr 19.

University of Texas, Austin, TX, USA. Electronic address:

Objective: To determine factors associated with performance and quality of lymph node dissection during radical nephrectomy.

Materials And Methods: Using an international data registry, we performed multilevel logistic regression to determine the association of surgical approach (open surgery vs. minimally invasive surgery), institutional experience (low, moderate and high tertiles), and institutional preference (minimally invasive surgery, balanced, and open surgery tertiles) with the performance of lymph node dissection in subgroups by clinical stage and nodal status. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.068DOI Listing

Review:Using the Idea, Development, Exploration, Assessment, Long-term study Framework for Devices (IDEAL-D) to better understand the evolution of evidence surrounding fenestrated abdominal aortic endovascular grafts.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Section of Vascular Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire. Electronic address:

The use of fenestrated endovascular devices for repair of complex aortic aneurysms has increased to nearly 5,000 implantations annually in Medicare patients in the United States in recent years. Given that nearly all aspects of treatment for minimally invasive aortic intervention rely on medical devices to better care for patients with vascular disease, a clear understanding how new and innovative technology evolves over the life cycle of a medical device is an essential skill set for cardiovascular physicians. Despite the need for this understanding, there is no standard framework upon which cardiovascular physicians, regulators, and patients can rely to better understand the evolution of evidence from product inception through adoption and long-term effectiveness evaluation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08905096193023
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http://dx.doi.org/10.1016/j.avsg.2019.02.010DOI Listing
April 2019
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How many cell types form the epithelial lining of the human uterine tubes? Revision of the histological nomenclature of the human tubal epithelium.

Ann Anat 2019 Apr 19. Epub 2019 Apr 19.

Institute of Pathological Anatomy, Faculty of Medicine, Comenius University in Bratislava, Špitálska Street 24, 813 72 Bratislava, Slovakia.

Introduction: Many widely used international histological textbooks claim that the epithelium of the human uterine tube consists of two, three, and, eventually, four types of cells. Most discrepancies among these textbooks relate to debates regarding the presence or absence of basal cells, whether the peg/intercalary cells and secretory cells are the same or distinct cell populations, and if the epithelium contains a population of immunologically active cells (T- and B-lymphocytes, NK cells, macrophages and dendritic cells) or dispersed endocrine cells.

Methods: Uterine tubes were obtained from 22 women (average age: 46. Read More

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http://dx.doi.org/10.1016/j.aanat.2019.03.012DOI Listing

Differential expression patterns of sodium potassium ATPase alpha and beta subunit isoforms in mouse brain during postnatal development.

Neurochem Int 2019 Apr 19. Epub 2019 Apr 19.

Ruhr University Bochum, Faculty of Chemistry and Biochemistry, Biochemistry II, Bochum, Germany; Ruhr University Bochum, International Graduate School for Neuroscience, Germany. Electronic address:

The sodium potassium ATPase (Na/K ATPase) is essential for the maintenance of a low intracellular Na and a high intracellular K concentration. Loss of function of the Na/K ATPase due to mutations in Na/K ATPase genes, anoxic conditions, depletion of ATP or inhibition of the Na/K ATPase function using cardiac glycosides such as digitalis, causes a depolarization of the resting membrane potential. While in non-excitable cells, the uptake of glucose and amino acids is decreased if the function of the Na/K ATPase is compromised, in excitable cells the symptoms range from local hyper-excitability to inactivating depolarization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01970186183045
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http://dx.doi.org/10.1016/j.neuint.2019.04.009DOI Listing
April 2019
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Blood and urine biomarkers in chronic kidney disease: An update.

Clin Chim Acta 2019 Apr 19. Epub 2019 Apr 19.

Nephrology Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; Nephrology Department, Serdang Hospital, Selangor, Malaysia.

Introduction: Chronic kidney disease (CKD) is a silent disease. Most CKD patients are unaware of their condition during the early stages of the disease which poses a challenge for healthcare professionals to institute treatment or start prevention. The trouble with the diagnosis of CKD is that in most parts of the world, it is still diagnosed based on measurements of serum creatinine and corresponding calculations of eGFR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193181
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http://dx.doi.org/10.1016/j.cca.2019.04.069DOI Listing
April 2019
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A path to cooperation between China and Mongolia towards the control of echinococcosis under the Belt and Road Initiative.

Acta Trop 2019 Apr 19. Epub 2019 Apr 19.

London School of Hygiene and Tropical Medicine, United Kingdom.

Health is the core of development. Health cooperation between countries plays a pivotal role under the 'Belt and Road' Initiative. In 2013, China launched its Belt and Road Initiative to improve the international cooperation of which health was an important component. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183108
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http://dx.doi.org/10.1016/j.actatropica.2019.04.022DOI Listing
April 2019
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Validation of an Electronic Medical Record-Based Algorithm for Identifying Posttraumatic Stress Disorder in U.S. Veterans.

J Trauma Stress 2019 Apr;32(2):226-237

Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, USA.

We developed an algorithm for identifying U.S. veterans with a history of posttraumatic stress disorder (PTSD), using the Department of Veterans Affairs (VA) electronic medical record (EMR) system. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jts.22399
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http://dx.doi.org/10.1002/jts.22399DOI Listing
April 2019
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Gender-Stratified Prevalence of Psychiatric and Pain Diagnoses in a Primary Care Patient Sample with Fibromyalgia.

Pain Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Family and Community Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, USA.

Objective: Comorbid psychiatric and pain-related conditions are common in patients with fibromyalgia. Most studies in this area have used data from patients in specialty care and may not represent the characteristics of fibromyalgia in primary care patients. We sought to fill gaps in the literature by determining if the association between psychiatric diagnoses, conditions associated with chronic pain, and fibromyalgia differed by gender in a primary care patient population. Read More

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http://dx.doi.org/10.1093/pm/pnz084DOI Listing
April 2019
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Revisions in the National Burn Repository Improve the Rate of Firefighter Injury Data Capture.

J Burn Care Res 2019 Apr 6. Epub 2019 Apr 6.

DC Firefighters Burn Fund Washington, DC.

Approximately 60,000 to 70,000 firefighters suffer work-related injuries per year in the United States. Approximately 10% of these injuries occur from burns or smoke inhalation. Previous analyses of the National Burn Repository (NBR) suggest that not all records of firefighter injuries are being captured. Read More

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http://dx.doi.org/10.1093/jbcr/irz039DOI Listing

Six Month Abstinence Heterogeneity in the Best Quit Study.

Ann Behav Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Background: Understanding the characteristics of smokers who are successful in quitting may help to increase smoking cessation rates.

Purpose: To examine heterogeneity in cessation outcome at 6 months following smoking cessation behavioral counseling with or without weight management counseling.

Methods: 2,540 smokers were recruited from a large quitline provider and then randomized to receive proactive smoking cessation behavioral counseling without or with two versions of weight management counseling. Read More

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https://academic.oup.com/abm/advance-article/doi/10.1093/abm
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http://dx.doi.org/10.1093/abm/kaz014DOI Listing
April 2019
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A cross-sectional survey on the seroprevalence of dengue fever in febrile patients attending health facilities in Cross River State, Nigeria.

PLoS One 2019 22;14(4):e0215143. Epub 2019 Apr 22.

Nuffield Centre for International Health and Development, University of Leeds, Leeds, United Kingdom.

Background: In Nigeria, recent reports suggest that dengue viruses could be a major cause of acute fevers. We sought to make a cross-sectional estimate of the prevalence of current and previous dengue infections in patients presenting with fever to healthcare centres in Cross River State Nigeria.

Methodology/principal Findings: This cross-sectional health facility survey recruited persons with temperature ≥38°C. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215143PLOS

Prognostic performance of preoperative cardiac troponin and perioperative changes in cardiac troponin for the prediction of major adverse cardiac events and mortality in noncardiac surgery: A systematic review and meta-analysis.

PLoS One 2019 22;14(4):e0215094. Epub 2019 Apr 22.

Department of Anesthesiology and Intensive Care, Medical and Health Sciences, Linköping University, Linköping, Sweden.

Background: Increased postoperative cardiac troponin (cTn) independently predicts short-term mortality. Previous studies suggest that preoperative cTn also predicts major adverse cardiovascular events (MACE) and mortality after noncardiac surgery. The value of preoperative and perioperative changes in cTn as a prognostic tool for adverse outcomes has been sparsely investigated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215094PLOS
April 2019
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Genetic and phenotypic characteristics of SCN1A-related epilepsy in Chinese children.

Neuroreport 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurology, Children's Hospital of Chongqing Medical University.

SCN1A gene mutations are associated with epilepsy and neurodevelopmental disorders. This study aimed to explore the genotype and phenotype spectrum of SCN1A gene related epilepsy. Epileptic patients who were treated in the Children's Hospital of Chongqing Medical University from January 2015 to July 2018 and identified as having SCN1A mutations by targeted next-generation sequencing were included. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001259DOI Listing

Validity and Reliability of a Light-Based Electronic Target for Testing Response Time in Fencers.

J Strength Cond Res 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychology, eCampus University, Novedrate, Italy.

De Giorgio, A, Iuliano, E, Turner, A, Millevolte, C, Cular, D, Ardigò, LP, and Padulo, J. Validity and reliability of a light-based electronic target for testing response time in fencers. J Strength Cond Res XX(X): 000-000, 2019-Response time (RT) is a fencing fundamental sensorimotor skill. Read More

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http://dx.doi.org/10.1519/JSC.0000000000003160DOI Listing

Comparison of Physical Fitness and Anthropometrical Profiles Among Brazilian Female Soccer National Teams From U15 to Senior Categories.

J Strength Cond Res 2019 Apr 11. Epub 2019 Apr 11.

Federal University of Minas Gerais, School of Physical Education, Physiotherapy and Occupational Therapy, Belo Horizonte, Minas Gerais, Brazil.

Ramos, GP, Nakamura, FY, Penna, EM, Mendes, TT, Mahseredjian, F, Lima, AM, Garcia, ES, Prado, LS, and Coimbra, CC. Comparison of physical fitness and anthropometrical profiles among Brazilian female soccer national teams from U15 to senior categories. J Strength Cond Res XX(X): 000-000, 2019-This study aimed to compare anthropometric and physical fitness of Brazilian female national team soccer players from the U15 to senior categories, and to compare the physical performance between selected and nonselected players. Read More

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http://dx.doi.org/10.1519/JSC.0000000000003140DOI Listing

Anterior nucleus of paraventricular thalamus mediates chronic mechanical hyperalgesia.

Pain 2019 May;160(5):1208-1223

Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan.

Pain-related diseases are the top leading causes of life disability. Identifying brain regions involved in persistent neuronal changes will provide new insights for developing efficient chronic pain treatment. Here, we showed that anterior nucleus of paraventricular thalamus (PVA) plays an essential role in the development of mechanical hyperalgesia in neuropathic and inflammatory pain models in mice. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001497DOI Listing

Prognostic significance of locally invaded sites and tissue types in patients with nasal extranodal natural-killer/T-cell lymphoma: a single-center, retrospective analysis.

Chin Med J (Engl) 2019 Jan 10. Epub 2019 Jan 10.

Key Laboratory of Head and Neck Molecular Pathological Diagnosis, Capital Medical University, Beijing 100730, China.

Background: Extranodal natural-killer/T-cell lymphoma (ENKTL), nasal-type, is an aggressive entity within the World Health Organization (WHO) classification of lymphoid tumors. The International Prognostic Index (IPI) is reported to be prognostically meaningful for ENKTL, but lacks discriminatory power for stage I/II ENKTL with extensive local invasion. This study aimed to evaluate the prognostic effects of local invasion by site and tissue type in patients with ENKTL. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000263DOI Listing
January 2019

Goodbye: an immigration story.

Authors:
Sarah E Stumbar

CMAJ 2019 Mar;191(9):E261-E262

Department of Humanities, Health and Society, Herbert Wertheim College of Medicine, Florida International University, Miami, Fla.

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http://dx.doi.org/10.1503/cmaj.180933DOI Listing

Combining Neurovascular and Neurodegenerative Magnetic Resonance Imaging Measures in Stroke.

Stroke 2019 May;50(5):1136-1139

From the Institute of Cardiovascular and Medical Sciences, University of Glasgow, Queen Elizabeth University Hospital, United Kingdom (A.W., J.D., D.A.D.).

Background and Purpose- Individual markers of cerebral small vessel disease and cerebral atrophy explain a small proportion of variance in vascular risk factors and cognitive function. Combining these markers into a single measure of neurovascular and neurodegenerative disease may be more powerful. We assessed this using data contained in the Virtual International Stroke Trials Archive - Prevention sub-archive. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.024181DOI Listing

Arteriopathy Influences Pediatric Ischemic Stroke Presentation, but Sickle Cell Disease Influences Stroke Management.

Stroke 2019 May;50(5):1089-1094

Departments of Pediatrics, Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas and Children's Health Dallas (M.M.D.).

Background and Purpose- Sickle cell disease (SCD) and arteriopathy are pediatric stroke risk factors that are not mutually exclusive. The relative contributions of sickled red blood cells and arteriopathy to stroke risk are unknown, resulting in unclear guidelines for primary and secondary stroke prevention when both risk factors are present. We hypothesized that despite similarities in clinical presentation and radiographic appearance of arteriopathies, stroke evaluation and management differ in children with SCD compared with those without SCD. Read More

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.022800
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http://dx.doi.org/10.1161/STROKEAHA.118.022800DOI Listing
May 2019
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Plant Proteome Databases and Bioinformatic Tools: An Expert Review and Comparative Insights.

OMICS 2019 Apr;23(4):190-206

1 Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.

Historically, plant biology studies have lagged behind systems biology studies in animals and humans. However, there are signs of positive change as evidenced by the rise of big data in plant proteomics, and the availability of data science tools and next-generation sequencing technologies. Currently, the sequence information on nearly 300 plant species is available although they are curated to varying degrees of sophistication. Read More

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http://dx.doi.org/10.1089/omi.2019.0024DOI Listing

A new high-throughput screening method to determine multiple dyes in herbs and spices.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2019 Apr 22:1-15. Epub 2019 Apr 22.

a Nestlé Research , Institute of Food Safety and Analytical Science , Lausanne , Switzerland.

The unauthorised addition of colours to herbs and spices is a recurrent issue affecting food business operators. Such a practice aims at improving food visual attractiveness, masking poor product quality, and/or compensating for natural colour variation with the ultimate goal to increase profits. To detect this fraud, a new LC-MS/MS method was developed for screening 58 dyes in both herbs and spices. Read More

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http://dx.doi.org/10.1080/19440049.2019.1596320DOI Listing

Eighteen Years of Holmium Laser Enucleation of the Prostate: A Single Center Experience.

J Urol 2019 Apr 22:101097JU0000000000000280. Epub 2019 Apr 22.

Department of Surgery, Division of Urology, McGill University Health Center , Montreal QC , Canada.

Purpose: To report our experience with long-term outcomes of the HoLEP procedure over a period of 18 years.

Materials And Methods: A review was performed of a prospectively collected database (March 1998 through June 2016) for patients undergoing HoLEP for symptomatic BPH performed or supervised by a single expert surgeon. Demographic and perioperative data were collected including the International Prostate Symptoms Score (IPSS), Quality of Life (QoL), peak flow rate (Qmax), post-void residual urine (PVR), and Prostate Specific Antigen (PSA). Read More

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http://dx.doi.org/10.1097/JU.0000000000000280DOI Listing
April 2019
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A vocabulary describing health-terms of movement quality - a phenomenological study of movement communication.

Disabil Rehabil 2019 Apr 22:1-10. Epub 2019 Apr 22.

e Department of Journalism and Communication , University Carlos III of Madrid , Madrid , Spain.

Purpose: The aim of the study was to develop a vocabulary targeting communication of health-terms of movement quality, establishing professional knowledge of a movement terminology usefull within rehabilitation.

Methods: A phenomenological study design was chosen, inviting movement experts working in rehabilitation to describe movement observations when a change into more functional, health related ways of moving appeared in the rehabilitation processes. 15 physiotherapy experts were recruited, five from the field of neurology, primary health care and psychiatry. Read More

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https://www.tandfonline.com/doi/full/10.1080/09638288.2019.1
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http://dx.doi.org/10.1080/09638288.2019.1585970DOI Listing
April 2019
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Development of a Biobank from a Legacy Collection in Universitas Gadjah Mada, Indonesia: Proposed Approach for Centralized Biobank Development in Low-Resource Institutions.

Biopreserv Biobank 2019 Apr 19. Epub 2019 Apr 19.

2 Biobank Development Team, Molecular Biology Laboratory, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada (FK-KMK UGM), Yogyakarta, Indonesia.

The establishment of a biobank requires specific expertise along with relatively expensive infrastructure and appropriate technology. This causes certain challenges in biobank implementation for research in low-middle-income countries. Biobank development with established specimens and data collection (legacy collection) was an approach used in the Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada. Read More

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http://dx.doi.org/10.1089/bio.2018.0125DOI Listing

Combination of Human Umbilical Vein Endothelial Cell Vaccine and Docetaxel Generates Synergistic Anti-Breast Cancer Effects.

Cancer Biother Radiopharm 2019 Apr 22. Epub 2019 Apr 22.

1 The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai, P.R. China.

A human umbilical vein endothelial cell (HUVEC) vaccine is a promising anti-angiogenesis therapy, but the modest therapeutic antitumor efficacy restricts its clinical use. Preclinical evidence supports the combination of antiangiogenic agents and chemotherapy for cancer treatment. In the present study, docetaxel (DOC) was combined with HUVEC vaccine to develop a HUVEC-DOC treatment regime. Read More

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http://dx.doi.org/10.1089/cbr.2018.2721DOI Listing

Anterior Cruciate Ligament Injury Risk in Sport: A Systematic Review and Meta-Analysis of Injury Incidence by Sex and Sport Classification.

J Athl Train 2019 Apr 22. Epub 2019 Apr 22.

Department of Athletic Training, Florida International University, Miami.

Objective: To evaluate sex differences in incidence rates (IRs) of anterior cruciate ligament (ACL) injury by sport type (collision, contact, limited contact, and noncontact).

Data Sources: A systematic review was performed using the electronic databases PubMed (1969-January 20, 2017) and EBSCOhost (CINAHL, SPORTDiscus; 1969-January 20, 2017) and the search terms AND AND ( OR OR ).

Study Selection: Studies were included if they provided the number of ACL injuries and the number of athlete-exposures (AEs) by sex or enough information to allow the number of ACL injuries by sex to be calculated. Read More

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http://dx.doi.org/10.4085/1062-6050-407-16DOI Listing

Torsion Angle Effect on the Activation of UiO Metal-Organic Frameworks.

ACS Appl Mater Interfaces 2019 Apr 22. Epub 2019 Apr 22.

International Institute of Nanotechnology, Department of Chemistry , Northwestern University , 2145 Sheridan Rd , Evanston , Illinois 60208 , United States.

We present a systematic investigation of the factors influencing the surface area of zirconium-based UiO-type metal-organic frameworks (MOFs), revealing an important relationship between factors including the conformation of the organic linker in the MOF, surface tension of the guest molecules (solvent), and the stability of MOFs toward activation (removal of guest molecules). The results obtained demonstrate how the structure of the linkers forming the isostructural series of UiO MOFs with fcu topology could alter the resistance and stability of the MOF frameworks toward capillary force-driven structural degradation governed by the solvent during activation. Read More

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http://pubs.acs.org/doi/10.1021/acsami.9b02764
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http://dx.doi.org/10.1021/acsami.9b02764DOI Listing
April 2019
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Variability in content and dissolution profiles of MDMA tablets collected in the UK between 2001 and 2018 - a potential risk to users?

Drug Test Anal 2019 Apr 22. Epub 2019 Apr 22.

Analytical Services International, St. George's University of London, Cranmer Terrace, London, SW17 0RE, UK.

MDMA ('ecstasy') tablets are widely used recreationally, and not only vary in their appearance, but also in MDMA content. Recently, the prevalence of high-content tablets is of concern to public health authorities. To compare UK data with other countries, we have evaluated MDMA content of 412 tablets collected from the UK, 2001-2018, and have investigated within-batch content variability for a sub-set of these samples. Read More

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http://dx.doi.org/10.1002/dta.2605DOI Listing

A Retrospective Database Review of the Indications, Complications, and Incidence of Subsequent Spine Surgery in 12,297 Spinal Cord Stimulator Patients.

Neuromodulation 2019 Apr 22. Epub 2019 Apr 22.

Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.

Study Design: Retrospective review.

Objective: To analyze the indications, incidence of minor and major complications, and rate of subsequent spinal surgery or revision after spinal cord stimulator (SCS) placement for degenerative spine disease.

Summary Of Background Data: Despite the application of SCS in various chronic pain conditions, there remains a growing debate on the efficacy and necessity of SCS in degenerative spine disease. Read More

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http://dx.doi.org/10.1111/ner.12952DOI Listing

Frequency of isolated cutaneous involvement in adult mastocytosis: a cohort study.

J Eur Acad Dermatol Venereol 2019 Apr 22. Epub 2019 Apr 22.

Reference Centre for Mastocytosis (CEREMAST) Toulouse, Department of Dermatology, Toulouse University Hospital, Paul Sabatier University, Toulouse, France.

Background: Mastocytosis is characterized by the accumulation/proliferation of abnormal mast cells. The frequency of isolated cutaneous involvement in adults with mastocytosis has not been fully determined. The main objective of our study was to assess the frequency of isolated cutaneous mastocytosis (CM) in adults with mastocytosis skin lesions. Read More

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http://dx.doi.org/10.1111/jdv.15638DOI Listing

Wheat ms5 male-sterility is induced by recessive homoeologous A and D genome non-specific Lipid Transfer Proteins.

Plant J 2019 Apr 22. Epub 2019 Apr 22.

School of Agriculture, Food & Wine, University of Adelaide, Waite Campus, Urrbrae, South Australia, 5064, Australia.

Nuclear male-sterile mutants with non-conditional, recessive and strictly monogenic inheritance are useful for both hybrid and conventional breeding systems and have long been a research focus for many crops. In allohexaploid wheat however, genic redundancy results in rarity of such mutants, with the EMS-induced mutant ms5 among the few reported to date. Here, we identify TaMs5 as a glycosylphosphatidylinositol anchored lipid transfer protein required for normal pollen exine development, and by transgenic complementation demonstrate that TaMs5-A restores fertility to ms5. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/tpj.14350
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http://dx.doi.org/10.1111/tpj.14350DOI Listing
April 2019
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A bibliometric study of the top 100 most-cited randomized controlled trials, systematic reviews, and meta-analyses published in endodontic journals.

Int Endod J 2019 Apr 22. Epub 2019 Apr 22.

Department of Oral and Maxillofacial Surgery, School of Dental Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.

Aim: To identify and analyse the main features of the top 100 most-cited randomized controlled trials, systematic reviews, and meta-analyses published in endodontic journals from 1961 to 2018.

Methodology: The Clarivate Analytics' Web of Science 'All Databases' was used to search and analyse the 100 most frequently cited randomized controlled trials, systematic reviews, and meta-analyses having "randomized", "randomised", "randomized controlled", "randomised controlled", "randomized controlled trial", "randomized controlled trials", "clinical trial", "systematic", "systematic review", "meta-analysis", and "meta-analyses" in the title section. The "International Endodontic Journal", "Journal of Endodontics", "Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology", "Australian Endodontic Journal", "Endodontics & Dental Traumatology", "Endo-Endodontic Practice Today", and "European Endodontic Journal" were included in the publication name section. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/iej.13131
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http://dx.doi.org/10.1111/iej.13131DOI Listing
April 2019
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Dataset for reporting of carcinoma of the urethra (in urethrectomy specimens): recommendations from the International Collaboration on Cancer Reporting (ICCR).

Histopathology 2019 Apr 22. Epub 2019 Apr 22.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, IUH Pathology Laboratory, Indianapolis, IN, USA.

Aims: The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation sponsored by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists in association with the Canadian Partnership Against Cancer, the European Society of Pathology, the American Society of Clinical Pathology and the Faculty of Pathology, Royal College of Physicians of Ireland. Its goal is to produce standardized, internationally agreed upon, evidence-based datasets for cancer pathology reporting throughout the world.

Methods And Results: This paper describes the development of a cancer dataset by the multidisciplinary ICCR expert panel for the reporting of carcinoma of the urethra in urethrectomy specimens. Read More

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http://dx.doi.org/10.1111/his.13877DOI Listing

Structures of a highly variable cell-wall anchored protein-encoding the spj gene from ST8/SCCmecIVl community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA/J) isolated from 2003 onwards: An indicator of a strongly invasive pathotype.

Microbiol Immunol 2019 Apr 22. Epub 2019 Apr 22.

Department of Epidemiology, Genomics, and Evolution, International Medical Education and Research Center, Niigata, Japan.

The cell wall-anchored protein-encoding spj gene on staphylococcal cassette chromosome mec IVl (SCCmecIVl) varied in size due to its 22- and 86-amino acid (aa) repeat domains. Of the two repeats, the 22-aa repeats were more flexible, comprising three 11-aa units, and were classified into three groups with eleven types. The 11/22-aa repeats were longer in bulluos impetigo cases, shorter in invasive cases, and absent in a fatal case, with the last one being rapidly diagnosed by PCR. Read More

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http://dx.doi.org/10.1111/1348-0421.12684DOI Listing

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay.

J Vis Exp 2019 Apr 5(146). Epub 2019 Apr 5.

Department of Neurology and Neuroscience Center, The First Hospital of Jilin University;

Anti-aquaporin-4 (AQP4) immunoglobulin G (IgG) is the core diagnostic biomarker for neuromyelitis optica spectrum disorders (NMOSD). The cell-based assay (CBA) is a widely used method to detect anti-AQP4 IgG in human serum with high sensitivity and specificity. Briefly, serum anti-AQP4 IgG is captured by AQP4-transfected cell that is fixed on the biochip then detected by a fluorescein-labelled secondary antibody. Read More

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http://dx.doi.org/10.3791/59014DOI Listing

Optimizing pediatric dosing recommendations and treatment management of antiretroviral drugs utilizing therapeutic drug monitoring data in children living with HIV.

Ther Drug Monit 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud university medical centre, Nijmegen, The Netherlands.

Introduction: This review summarises the current dosing recommendations for antiretroviral drugs (ARVs) in the international pediatric guidelines of the World Health Organisation (WHO), US Department of Health and Human Services (DHHS), and Paediatric European Network for Treatment of AIDS (PENTA) and evaluates the research that informed these approaches. We further explore the role of data generated through therapeutic drug monitoring (TDM) in optimizing the dosing of ARVs in children.

Methods: A PubMed search was conducted for literature on ARV dosing published in English. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000637DOI Listing

Maternal lipid profiles in women with and without gestational diabetes mellitus.

Medicine (Baltimore) 2019 Apr;98(16):e15320

Department of Obstetrics and Gynecology, Peking University International Hospital, Beijing, China.

To determine the longitude lipid profiles in women with and without gestational diabetes mellitus (GDM), and to investigate the relationship between lipid disturbances in the 1st trimester and GDM.Blood samples were collected from 1283 normal pregnant women and 300 women with GDM. Serum lipids which include total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured and the TG/HDL-C ratio was calculated in the 1st, 2nd, and 3rd trimesters of pregnancy and then we got the longitudinal lipid profiles. Read More

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http://dx.doi.org/10.1097/MD.0000000000015320DOI Listing

Neuronavigator-guided ventriculoscopic approach for symptomatic xanthogranuloma of the choroid plexus in the lateral ventricle.

Medicine (Baltimore) 2019 Apr;98(16):e14718

Department of Neurosurgery, Peking University International Hospital.

Xanthogranuloma of choroid plexus is an extremely rare, benign, and mostly asymptomatic intracranial lesion. We report a case of symptomatic lateral ventricular xanthogranuloma resected via a neuronavigator-guided ventriculoscopic approach. Then we review recent English medical literature and notice that craniotomies have been the most popular treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000014718DOI Listing
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