785 results match your criteria International Journal of General Medicine [Journal]


Atrial fibrillation: risk factors and comorbidities in a tertiary center in Jeddah, Saudi Arabia.

Int J Gen Med 2019 11;12:71-77. Epub 2019 Jan 11.

Department of Internal Medicine, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia,

Introduction: Atrial fibrillation (AF) is the most common type of cardiac arrhythmia worldwide and carries significant risk of morbidity and mortality. The prevalence of AF is high in significant parts of the world, but not much is known from countries, such as Saudi Arabia.

Aims: To study the risk factors, etiologies, comorbidities, and outcome of AF in Saudi Arabia. Read More

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http://dx.doi.org/10.2147/IJGM.S188524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333319PMC
January 2019
6 Reads

Population awareness of coronary artery disease risk factors in Jeddah, Saudi Arabia: a cross-sectional study.

Int J Gen Med 2019 11;12:63-70. Epub 2019 Jan 11.

Department of Internal Medicine, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia,

Background: Coronary artery disease (CAD) is a serious cardiovascular disorder affecting middle-aged individuals. It is a major cause of death among adults over the age of 35 years. In Saudi Arabia, CAD is associated with higher mortality rate, and Saudi patients are reported to have significantly higher prevalence of risk factors for CAD than the Western population. Read More

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http://dx.doi.org/10.2147/IJGM.S184732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333320PMC
January 2019
4 Reads

Trends in mitral valve prolapse: a tertiary care center experience in Jeddah, Saudi Arabia.

Int J Gen Med 2019 14;12:55-61. Epub 2019 Jan 14.

Department of Internal Medicine, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia,

Background: Mitral valve prolapse (MVP) is the most common cardiac valvular abnormality in developed countries and it is associated with considerable morbidity and mortality.

Aim Of Work: To study the clinical presentations, risk factors, and echocardiographic features of patients with MVP in Jeddah, Saudi Arabia.

Materials And Methods: A retrospective chart review study was conducted in King Abdulaziz teaching hospital in Jeddah, Saudi Arabia, from 2007 to 2017. Read More

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http://dx.doi.org/10.2147/IJGM.S177635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336028PMC
January 2019
1 Read

Peripheral artery disease risk factors in Jeddah, Saudi Arabia: a retrospective study.

Int J Gen Med 2019 8;12:49-54. Epub 2019 Jan 8.

Department of Internal Medicine, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia,

Background: Peripheral artery disease (PAD) is a major health problem in Saudi Arabia with considerable implications for morbidity and mortality. Many risk factors have been established for developing PAD, but the prevalence of these risk factors is variable from one country to another.

Aim: To identify the risk factors for PAD and study their prevalence in Jeddah, Saudi Arabia. Read More

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http://dx.doi.org/10.2147/IJGM.S176451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329343PMC
January 2019
1 Read

From the diagnosis to the therapeutic management: cerebral fat embolism, a clinical challenge.

Int J Gen Med 2019 4;12:39-48. Epub 2019 Jan 4.

Intensive Rehabilitation Unit, IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy,

Cerebral fat embolism (CFE) is an uncommon incomplete type of fat embolism syndrome (FES), characterized by purely cerebral involvement. It usually occurs 12-72 hours after the initial trigger, mainly represented by closed, long-bone multiple fractures of the lower extremities. Neurological manifestations are mainly characterized by headache, confusion, seizures, focal deficit, and alteration of the consciousness state up to coma onset. Read More

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http://dx.doi.org/10.2147/IJGM.S177407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324602PMC
January 2019

Knowledge and practice of dry powder inhalation among patients with chronic obstructive pulmonary disease in a regional hospital, Nepal.

Int J Gen Med 2019 24;12:31-37. Epub 2018 Dec 24.

Department of Nursing, Pokhara Campus, Tribhuvan University, Institute of Medicine, Pokhara, Nepal,

Purpose: Dry powder inhalation is a cornerstone of treatment in patients with COPD. This study was undertaken to study the knowledge and practice of dry powder inhalation among such patients.

Patients And Methods: The current study was a cross-sectional study conducted in Western Regional Hospital, Pokhara, Nepal. Read More

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http://dx.doi.org/10.2147/IJGM.S165659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307686PMC
December 2018

Bubble CPAP therapy for neonatal respiratory distress in level III neonatal unit in Amman, Jordan: a prospective observational study.

Int J Gen Med 2019 24;12:25-30. Epub 2018 Dec 24.

Pediatric department, Geisel School of Medicine, Dartmouth University, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.

Purpose: Bubble continuous positive airway pressure (bCPAP), a noninvasive respiratory support modality used to manage newborns with respiratory distress, provides continuous pressure that helps prevent derecruitment of alveoli, increasing the lungs' functional residual capacity, and thus decreasing the work of breathing. bCPAP can be used to manage various respiratory conditions in the newborn. In this prospective study, we describe our experience using bCPAP therapy as the primary respiratory support in a level III neonatal unit in Amman, Jordan. Read More

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http://dx.doi.org/10.2147/IJGM.S185264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307683PMC
December 2018
2 Reads

Cholangiocarcinoma: a guide for the nonspecialist.

Int J Gen Med 2019 20;12:13-23. Epub 2018 Dec 20.

Division of Surgery and Cancer, Imperial College London, London W2 INY, UK,

Cholangiocarcinoma (CCA) is a tumor with increasing prevalence around the world. The prevalence of CCA is highest in East Asia and most significantly in the countries through which the Mekong River flows, owing to the presence of liver flukes, which are consumed in raw fish dishes. Outside Asia, the causes of bile duct cancers for the most part are unknown. Read More

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http://dx.doi.org/10.2147/IJGM.S186854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304240PMC
December 2018
17 Reads

The relation of serum prolactin levels and infection in humans.

Int J Gen Med 2019 20;12:7-12. Epub 2018 Dec 20.

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran,

Background: is an intracellular protozoan parasite distributed worldwide. Although the infection is benign in immunocompetent individuals, it is life threatening and complicated in immunocompromised patients and fetuses of pregnant women who received their first exposure to during the pregnancy. Prolactin (PRL) is a hormone that is secreted by the pituitary gland, and it is confirmed that it plays a role in the immune system. Read More

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http://dx.doi.org/10.2147/IJGM.S188525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304245PMC
December 2018
14 Reads

Factors associated with carotid intima-media thickness in patients on maintenance hemodialysis.

Int J Gen Med 2019 18;12:1-6. Epub 2018 Dec 18.

Department of Radiology, Faculty of Medicine, Udayana University, Sanglah Hospital, Denpasar, Indonesia.

Purpose: The aim of this study was to analyze the association of the carotid intima-media thickness (CIMT) with various parameters in patients on maintenance hemodialysis (mHD).

Methods: A cross-sectional study was conducted, enrolling 68 subjects (41 men, 27 women) on mHD in the Hemodialysis Unit, Sanglah Hospital, Denpasar, Indonesia. CIMT was measured with B-mode ultrasonography using a USG Sonoace 8000 and a 7. Read More

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http://dx.doi.org/10.2147/IJGM.S178276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304075PMC
December 2018
4 Reads

Comparison of nine coronary risk scores in evaluating patients presenting to hospital with undifferentiated chest pain.

Int J Gen Med 2018 13;11:473-481. Epub 2018 Dec 13.

Department of Internal Medicine and Clinical Epidemiology, Princess Alexandra Hospital, Brisbane, QLD, Australia,

Introduction: We compared performance of nine risk scores for coronary heart disease (CHD) among patients presenting to an emergency department (ED) with undifferentiated chest pain of possible coronary origin.

Methods: A retrospective study was undertaken of adult patients presenting with chest pain to atertiary hospital ED with no electrocardiographs or troponin results diagnostic of ischemic chest pain (ICP) or acute coronary syndrome at ED presentation, and no clearly evident noncoronary diagnosis. Risk scores were applied using cut-points distinguishing low- from high-risk patients according to discharge diagnosis of noncardiac chest pain (NCCP) or ICP, respectively. Read More

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http://dx.doi.org/10.2147/IJGM.S183583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296689PMC
December 2018
1 Read

Hospitalization rate and outcomes in patients with left ventricular dysfunction receiving hemodialysis.

Int J Gen Med 2018 6;11:463-472. Epub 2018 Dec 6.

Department of Internal Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

Introduction: Left ventricular dysfunction (LVD) is characterized as left ventricular ejection fraction (EF) below half of the systolic capacity of the left ventricle. Patients on hemodialysis have higher risk of developing LVD than the general population. Our aim was to assess hospitalization rate and outcomes in hemodialysis patients with LVD. Read More

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http://dx.doi.org/10.2147/IJGM.S179206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287513PMC
December 2018

Association between type 2 diabetes mellitus and hypothyroidism: a case-control study.

Int J Gen Med 2018 4;11:457-461. Epub 2018 Dec 4.

Faculty of Medicine, Department of Family and Community Medicine, King Abdulaziz University, Jeddah, Saudi Arabia,

Objectives: Type 2 diabetes mellitus (DM-II) is highly prevalent in Saudi Arabia and only few studies have assessed it as a risk factor for hypothyroidism. This study aimed to examine the association between DM-II and hypothyroidism.

Subjects And Methods: We conducted a hospital-based case-control study. Read More

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http://dx.doi.org/10.2147/IJGM.S179205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287518PMC
December 2018
1 Read

Spectrum of bactericidal action of amylmetacresol/2,4-dichlorobenzyl alcohol lozenges against oropharyngeal organisms implicated in pharyngitis.

Int J Gen Med 2018 28;11:451-456. Epub 2018 Nov 28.

Reckitt Benckiser Healthcare International Ltd, Slough, Berkshire, UK,

Purpose: Pharyngitis is commonly caused by a self-limiting upper respiratory tract infection (URTI) and symptoms typically include sore throat. Antibiotics are often inappropriately used for the treatment of pharyngitis, which can contribute to antimicrobial resistance, therefore non-antibiotic treatments which have broad antiseptic effects may be more appropriate. Amylmetacresol (AMC) and 2,4-dichlorobenzyl alcohol (DCBA) are present in some antiseptic lozenges and have established benefits in providing symptomatic relief and some in vitro antiviral action. Read More

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http://dx.doi.org/10.2147/IJGM.S184406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276617PMC
November 2018
15 Reads

The impact of sarcopenic obesity on inflammation, lean body mass, and muscle strength in elderly women.

Int J Gen Med 2018 22;11:443-449. Epub 2018 Nov 22.

Department of Physical Education, Catholic University of Brasilia (UCB), Brasilia, Brazil,

Objective: The objective of this study was to apply the newly standardized definition for sarcopenia from the Foundation for the National Institutes of Health (FNIH) and the current definition for obesity to 1) determine the prevalence of sarcopenic obesity (SO) in obese elderly women; 2) compare the muscle strength, lean body mass, and markers of inflammation between obese elderly women with SO and nonsarcopenic obesity (NSO), and 3) elucidate the relationship between appendicular lean mass adjusted for body mass index (aLM/BMI) with muscle strength, lean body mass, and obesity indices.

Methods: A total of 64 elderly obese women (age: 68.35±6. Read More

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http://dx.doi.org/10.2147/IJGM.S187285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254502PMC
November 2018
3 Reads

Hypoxia and hyperbaric oxygen therapy: a review.

Authors:
Ryan Choudhury

Int J Gen Med 2018 20;11:431-442. Epub 2018 Nov 20.

Department of Internal Medicine, Graduate Medical Education, St Vincent Charity Medical Center, Cleveland, OH, USA,

Hypoxia causes a cascade of activity from the level of the individual down to the regulation and function of the cell nucleus. Prolonged periods of low oxygen tension are a core feature of several disease states. Advances in the study of molecular biology have begun to bridge the gap between the cellular response to hypoxia and physiology. Read More

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http://dx.doi.org/10.2147/IJGM.S172460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251354PMC
November 2018
1 Read

A case of a patient with severe epidermolysis bullosa surviving to adulthood.

Int J Gen Med 2018 15;11:413-421. Epub 2018 Nov 15.

Department of Skin and Venereal Diseases, I.M. Sechenov First Moscow State Medical University, Moscow, Russia,

Purpose: The aim of this study was to evaluate the progression of a case of a patient with epidermolysis bullosa (EB) since early age who survived to adulthood, presenting with recurrent skin blisters and disfiguring scars and disabling musculoskeletal deformities.

Background: EB is a rare group of inherited diseases that affect the skin fragility causing it to blister in response to even minor trauma. Established novel treatments are limited in the literature due to its rarity, and more research is needed to set a global management approach. Read More

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http://dx.doi.org/10.2147/IJGM.S180464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241716PMC
November 2018
4 Reads

The prognostic impact of neutrophil to lymphocyte ratio in advanced non-small cell lung cancer patients treated with EGFR TKI.

Int J Gen Med 2018 19;11:423-430. Epub 2018 Nov 19.

Laboratory D Unit, Clinical Cancer Center, Cho Ray Hospital, Ho Chi Minh City, Vietnam,

Purpose: To identify and clarify the roles of inflammatory markers in prognosis for advanced non-small cell lung cancer (NSCLC) patients treated with EGFR tyrosine kinase inhibitor (TKI).

Patients And Methods: One hundred and twelve adenocarcinoma, clinical stage IV, NSCLC patients with either exon 19 deletion (E19del) or exon 21 L858R substitution mutation (L858R) were selected for this study. The blood cell count at different stages of treatment was used to calculate the inflammatory markers. Read More

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http://dx.doi.org/10.2147/IJGM.S174605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250106PMC
November 2018
14 Reads

Effect of a do-not-resuscitate order on the quality of care in acute heart failure patients: a single-center cohort study.

Int J Gen Med 2018 16;11:405-412. Epub 2018 Oct 16.

Department of Cardiology, Tokyo Bay Urayasu Ichikawa Medical Center, Todaijima, Urayasu-city, Chiba 279-0001, Japan.

Background: A do-not-resuscitate (DNR) order is reportedly associated with a decrease in performance measures, but it should not be applied to noncardiopulmonary resuscitation procedures. Good performance measures are associated with improvement in heart failure outcomes.

Aim: To analyze the influence of DNR order on performance measures of heart failure at our hospital, where lectures on DNR order are held every 3 months. Read More

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http://dx.doi.org/10.2147/IJGM.S173253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198884PMC
October 2018
6 Reads

Primary hepatocellular carcinoma in a patient with history of treated breast cancer: a case report with challenging diagnosis and treatment.

Int J Gen Med 2018 11;11:399-403. Epub 2018 Oct 11.

Department of Surgery, Interbalkan European Medical Center, Thessaloniki, Greece.

Introduction: Breast cancer is the most common malignancy in women worldwide. Long-term survivors among patients treated for breast cancer are at a high risk for developing a second primary malignancy. Hepatocellular carcinoma is the most frequent primary hepatic malignancy and should be ruled out in breast cancer patients who are diagnosed with solitary hepatic lesions. Read More

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https://www.dovepress.com/primary-hepatocellular-carcinoma-i
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http://dx.doi.org/10.2147/IJGM.S176052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188071PMC
October 2018
9 Reads

What factors influence the use of electronic health records during the first 10 minutes of the clinical encounter?

Int J Gen Med 2018 9;11:393-398. Epub 2018 Oct 9.

Department of Community Medicine, Primary Care and Emergencies, Geneva University Hospitals, Geneva, Switzerland.

Purpose: The use of electronic health records (EHRs) by physicians during the consultation is common and can be problematic. Factors influencing the use of EHRs during clinical encounters include physician and patient characteristics, consultation type as well as spatial organization of the room and type of EHR template. Their relative importance is however not well known. Read More

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http://dx.doi.org/10.2147/IJGM.S178672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6183548PMC
October 2018
11 Reads

Clinical profile of viper envenomations in Kerala, India: some unanswered questions.

Int J Gen Med 2018 3;11:391-392. Epub 2018 Oct 3.

Department of Internal Medicine, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.

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http://dx.doi.org/10.2147/IJGM.S177509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175540PMC
October 2018

Quality of care delivered to type 2 diabetes mellitus patients in public and private sector facilities in Johannesburg, South Africa.

Int J Gen Med 2018 2;11:383-390. Epub 2018 Oct 2.

School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Purpose: With the realities of resource constraints existing in South Africa's public sector and the evidence of disparities in health care between populations, the study sought to compare the quality of diabetes care and health-related quality of life (HRQoL) in patients with type 2 diabetes mellitus (T2DM) receiving care within two specialized settings: one in the public and the other in the private sector. Particular emphasis was placed on complication rates at the two sites.

Patients And Methods: Quantitative and qualitative data were collected between June and October 2016 from existing patients' records at each setting. Read More

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http://dx.doi.org/10.2147/IJGM.S165545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173174PMC
October 2018

Relapsing fever in California: a pilot serological study.

Int J Gen Med 2018 21;11:373-382. Epub 2018 Sep 21.

Union Square Medical Associates, San Francisco, CA, USA,

Background: spirochetes are tick-borne Gram-negative bacteria that cause disease in humans and animals. Although many studies have focused on (Bb), the agent of Lyme disease, recent studies have examined the role of Relapsing Fever (RFB) in human disease. In this pilot study, we have evaluated serological reactivity against Bb and RFB in patients residing in California. Read More

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https://www.dovepress.com/relapsing-fever-borrelia-in-califo
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http://dx.doi.org/10.2147/IJGM.S176493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160281PMC
September 2018
13 Reads

Mini-laparoscopic cholecystectomy with the MiniLap percutaneous surgical system: a series of 32 patients.

Int J Gen Med 2018 20;11:369-371. Epub 2018 Sep 20.

Third Department of Surgery, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: In recent years, mini-laparoscopic procedures are gaining the preference of most surgeons due to their potentially better surgical outcomes. The Mini Lap Percutaneous Surgical System with MiniGrip Handle is currently the less invasive instrument and can be applied to a wide range of operations. The current paper presents its application on percutaneous laparoscopic cholecystectomy. Read More

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http://dx.doi.org/10.2147/IJGM.S172655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160271PMC
September 2018
3 Reads

Coexistence of primary colorectal follicular lymphoma and multiple myeloma: a case report.

Int J Gen Med 2018 12;11:363-367. Epub 2018 Sep 12.

Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Colorectal follicular lymphoma (FL) occurs less frequently than duodenal-type FL, which is an established entity, and primary multiple FL only involving the colon is rare. Furthermore, the coexistence of lymphoma and multiple myeloma (MM) within the same patient is rare and the current study reports such a case. The patient was an asymptomatic 62-year-old man. Read More

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http://dx.doi.org/10.2147/IJGM.S171387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140731PMC
September 2018
10 Reads

Examination of biomarker expressions in sepsis-related DIC patients.

Int J Gen Med 2018 12;11:353-361. Epub 2018 Sep 12.

First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan,

Background: Disseminated avascular coagulation (DIC) is the main cause of death among patients with sepsis. In particular, low platelet count is predictive of poor outcome. However, the significance of platelet activation in patients with sepsis-related DIC is poorly understood. Read More

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http://dx.doi.org/10.2147/IJGM.S173684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140747PMC
September 2018
3 Reads

Received care compared to ADP-guided care of patients admitted to hospital with chest pain of possible cardiac origin.

Int J Gen Med 2018 3;11:345-351. Epub 2018 Sep 3.

Medical Assessment and Planning Unit, Princess Alexandra Hospital, Brisbane, QLS, Australia.

Purpose: To assess the extent to which accelerated diagnostic protocols (ADPs), compared to traditional care, identify patients presenting to emergency departments (EDs) with chest pain who are at low cardiac risk and eligible for early ED discharge.

Patients And Methods: Retrospective study of 290 patients admitted to hospital for further evaluation of chest pain following negative ED workup (no acute ischemic electrocardiogram [ECG] changes or elevation of initial serum troponin assay). Demographic data, serial ECG and troponin results, Thrombolysis in Myocardial Infarction (TIMI) score, cardiac investigations, and outcomes (confirmed acute coronary syndrome [ACS] at discharge and major adverse cardiac events [MACEs]) over 6 months of follow-up were analyzed. Read More

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http://dx.doi.org/10.2147/IJGM.S166570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128279PMC
September 2018
3 Reads

Acromegaly: a challenging condition to diagnose.

Authors:
Salma AlDallal

Int J Gen Med 2018 24;11:337-343. Epub 2018 Aug 24.

Haematology & Blood Bank Department, Amiri Hospital, Kuwait Ministry of Health, Sharq, Kuwait,

Acromegaly is an uncommon, chronic disease, characterized by hypersecretion of a pituitary growth hormone by somatotroph adenomas, along with increased levels of insulin-like growth factor-1. Although acromegaly presents a wide array of clinical manifestations, the salient symptoms include acral and soft tissue enlargement, joint pain, heart and respiratory failure, diabetes mellitus, and hypertension, leading to increased morbidity and mortality. Hence, early diagnosis of the disease is critical to enhance life expectancy and quality of life. Read More

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http://dx.doi.org/10.2147/IJGM.S169611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112775PMC
August 2018
14 Reads

Role of intravenous iron in the treatment of anemia in patients with gastrointestinal tract tumors undergoing chemotherapy: a single-center, observational study.

Int J Gen Med 2018 22;11:331-336. Epub 2018 Aug 22.

Medical Oncology Department, Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE, Vila Real, Portugal,

Purpose: The prevalence of anemia ranges between 30% and 90% in cancer patients, affecting the health status, quality of life, and treatment outcome. Therefore, a proper diagnosis and management of anemia is crucial in these patients. Iron deficiency is diagnosed in~32%-60% of the cases. Read More

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http://dx.doi.org/10.2147/IJGM.S165947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112805PMC
August 2018
1 Read

Clinical utility of plecanatide in the treatment of chronic idiopathic constipation.

Int J Gen Med 2018 10;11:323-330. Epub 2018 Aug 10.

Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA,

Constipation is an important health burden that reduces the quality of life for countless millions of people. Symptom-centric therapeutics are often used to treat constipation due to unknown etiology, but in many cases, these drugs are either inadequate or have significant side effects. More recently, synthetic peptide agonists for epithelial guanylyl cyclase C (GC-C) have been developed which are effective at treating constipation in a sub-population of adult constipation patients. Read More

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http://dx.doi.org/10.2147/IJGM.S125051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089121PMC
August 2018
3 Reads

Expert opinion on the applicability of dyslipidemia guidelines in Asia and the Middle East.

Int J Gen Med 2018 18;11:313-322. Epub 2018 Jul 18.

Department of Cardiology, Institut Jantung Negara, Kuala Lumpur, Malaysia.

Cardiovascular disease (CVD) is a growing burden across the world. In Asia and the Middle East, in particular, CVD is among the most prevalent and debilitating diseases. Dyslipidemia is an important factor in the development of atherosclerosis and associated cardiovascular events, and so effective management strategies are critical to reducing overall cardiovascular risk. Read More

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http://dx.doi.org/10.2147/IJGM.S160555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055898PMC
July 2018
8 Reads

Fever of unknown origin following parathyroidectomy prior to onset of typical polymyalgia rheumatica symptoms: a case report.

Int J Gen Med 2018 16;11:307-311. Epub 2018 Jul 16.

Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Polymyalgia rheumatica (PMR) is a disease commonly seen in elderly individuals, however, the etiology has not been reported. Typical clinical features include bilateral shoulder pain and morning stiffness, while serologic autoantibody test findings are negative. Approximately 40%-50% of affected patients present with low-grade fever, fatigue, and appetite loss, which we often experience in the field of general medicine, and thus, the condition should not be given low priority. Read More

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http://dx.doi.org/10.2147/IJGM.S159364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052921PMC
July 2018
7 Reads

A unique finding of cavum velum interpositum colloid-like cyst and literature review of a commonplace lesion in an uncommon place.

Int J Gen Med 2018 16;11:301-305. Epub 2018 Jul 16.

Diagnostic Radiology Department, Dammam Central Hospital, Dammam, Eastern Province, Saudi Arabia.

Colloid cysts typically reside within the area of the anterior third ventricle, in the proximity of the foramen of Monro. Although they are considered to commonly localize in various parts of the cerebrum, they are exceedingly rare outside the ventricular system and rarely occur within the velum interpositum. We have reported here a rare case of a velum interpositum colloid-like cyst in a 23-year-old man, who presented to our clinic with temporary binocular strabismus, which he had been experiencing for the previous year. Read More

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http://dx.doi.org/10.2147/IJGM.S169018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052918PMC
July 2018
31 Reads

Clinical and microbiological characteristics and occurrence of infection in Japan.

Int J Gen Med 2018 13;11:293-299. Epub 2018 Jul 13.

Department of Infection Control and Prevention, The University of Tokyo Hospital, Hongo, Bunkyo-ku, Tokyo, Japan.

Purpose: is a pathogen that causes pneumonia and urinary tract infection. Hypervirulent strains often show hypermucoviscosity, are of the K1 or K2 serotype, and harbor the and genes. However, the differences in the prevalence of with these hypervirulent characteristics between the infection and colonization status are not well understood. Read More

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http://dx.doi.org/10.2147/IJGM.S166940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049057PMC
July 2018
2 Reads
1 Citation

Altered levels of cytokines in patients with irritable bowel syndrome are not correlated with fatigue.

Int J Gen Med 2018 6;11:285-291. Epub 2018 Jul 6.

Centre of Nutrition, Department of Clinical Medicine, University of Bergen, Bergen, Norway,

Introduction: A considerable number of patients with gastrointestinal complaints attributable to irritable bowel syndrome (IBS) have shown evidence of immune activation. Fatigue is also frequently reported by IBS patients and the condition is considered as a common comorbidity of IBS. Therefore, it is interesting to see whether these two conditions share the same pathophysiological mechanism. Read More

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http://dx.doi.org/10.2147/IJGM.S166600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038856PMC
July 2018
7 Reads

Development of a nasal spray containing xylometazoline hydrochloride and iota-carrageenan for the symptomatic relief of nasal congestion caused by rhinitis and sinusitis.

Int J Gen Med 2018 4;11:275-283. Epub 2018 Jul 4.

Marinomed Biotech AG, Vienna, Austria,

Introduction: Xylometazoline hydrochloride (HCl) is a nasal decongestant that causes vasoconstriction in the nasal submucosa. It has been used for more than 50 years for the treatment of nasal congestion caused by rhinitis/sinusitis. Iota-carrageenan is effective against a broad variety of respiratory viruses, which are the most common cause of infections of the upper respiratory tract. Read More

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http://dx.doi.org/10.2147/IJGM.S167123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037157PMC
July 2018
15 Reads

Evaluating the use of corticosteroids in preventing and treating bronchopulmonary dysplasia in preterm neonates.

Int J Gen Med 2018 3;11:265-274. Epub 2018 Jul 3.

Faculty of Medicine, Imperial College, London, UK.

Approximately 15 million babies worldwide are born premature, and complications of prematurity are one of the leading causes of death in neonates. Neonatal respiratory distress syndrome (NRDS) and bronchopulmonary dysplasia (BPD) are two of the most common and serious consequences of prematurity. Synthetic corticosteroids, including dexamethasone, have been central in efforts to treat and prevent BPD. Read More

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http://dx.doi.org/10.2147/IJGM.S158184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037151PMC
July 2018
14 Reads

The increasing prevalence of non-communicable diseases in low-middle income countries: the view from Malawi.

Int J Gen Med 2018 28;11:255-264. Epub 2018 Jun 28.

Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, London, UK,

Non-communicable diseases (NCDs) are the leading cause of death globally, the majority of these being due to cardiovascular disease, cancer, chronic respiratory diseases, or diabetes. Mortality from many NCDs continues to increase worldwide, with a disproportionately larger impact in low-middle income countries (LMIs), where almost 75% of global deaths occur from these causes. As a low-income African country that consistently ranks amongst the world's poorest nations, Malawi as a case study demonstrates how transition due to societal change and increasing urbanization is often accompanied by a rise in the rate of NCDs. Read More

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http://dx.doi.org/10.2147/IJGM.S157987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029598PMC
June 2018
1 Read

Understanding short-term blood-pressure-variability phenotypes: from concept to clinical practice.

Int J Gen Med 2018 22;11:241-254. Epub 2018 Jun 22.

Medical Affairs, Pfizer, Singapore.

Clinic blood pressure (BP) is recognized as the gold standard for the screening, diagnosis, and management of hypertension. However, optimal diagnosis and successful management of hypertension cannot be achieved exclusively by a handful of conventionally acquired BP readings. It is critical to estimate the magnitude of BP variability by estimating and quantifying each individual patient's specific BP variations. Read More

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http://dx.doi.org/10.2147/IJGM.S164903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018855PMC
June 2018
1 Read

Stroke in-hospital survival and its predictors: the first results from Tabriz Stroke Registry of Iran.

Int J Gen Med 2018 19;11:233-240. Epub 2018 Jun 19.

Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Objective: The aim of this study was to determine the in-hospital survival of patients referred to the 2 stroke centers in North-West of Iran during a full seasonal year from April 2015.

Methods: All the consecutive patients with stroke admitted to the 2 main stroke centers at Tabriz (Imam Reza University Hospital and Razi University Hospital) were recruited in this study. Stroke patients from both ischemic and hemorrhagic subtypes were selected based on the registry data and International Classification of Diseases, 10th edition. Read More

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http://dx.doi.org/10.2147/IJGM.S158296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016014PMC
June 2018
2 Reads

Venous thromboembolism risk assessments on trauma patients has suboptimal interobserver reliability among inexperienced clinicians (fourth-year medical students).

Int J Gen Med 2018 18;11:225-231. Epub 2018 Jun 18.

Department of Surgery, Richmond University Medical Center, Staten Island, NY, USA.

Background: Venous thromboembolic disease is a major cause of morbidity and mortality in hospitalized patients worldwide. The objective of this study is to compare interobserver reliability for qualitative and quantitative venous thromboembolism (VTE) risk assessments in hospitalized trauma patients.

Methods: We conducted a retrospective medical record review of 40 randomly selected trauma patients admitted to a 448-bed urban level-I trauma center from January 2013 to January 2014. Read More

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http://dx.doi.org/10.2147/IJGM.S162025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012549PMC
June 2018
15 Reads

Association of serum procalcitonin and C-reactive protein levels with CURB-65 criteria among patients with community-acquired pneumonia.

Int J Gen Med 2018 13;11:217-223. Epub 2018 Jun 13.

Research Center for Health Sciences, Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: The concentration of diagnostic markers such as inflammatory biomarkers including procalcitonin (PCT) and C-reactive protein (CRP) increases in bacterial infections. The aim of this study was to compare serum PCT and CRP levels with CURB-65 ranking, in the patients with community-acquired pneumonia (CAP).

Patients And Methods: In a cross-sectional study, 93 hospitalized patients with a definite diagnosis of CAP, considering inclusion and exclusion criteria, were enrolled. Read More

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http://dx.doi.org/10.2147/IJGM.S165190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005316PMC
June 2018
17 Reads

Clinical and epidemiologic profile and predictors of outcome of poisonous snake bites - an analysis of 1,500 cases from a tertiary care center in Malabar, North Kerala, India.

Int J Gen Med 2018 5;11:209-216. Epub 2018 Jun 5.

Department of General Medicine, Government Medical College, Kozhikode, Kerala, India.

Background: Snake bites are a neglected public health problem in all tropical countries, and particularly in Malabar region of Kerala, India. Demographic characteristics and clinical parameters vary in this part of the world, and studies based on them are scarce. Increased incidence of capillary leak syndrome (CLS) in hemotoxic snake bites and emergence of cases of hump-nosed pit viper (HNPV, ) envenomation are some notable features seen here. Read More

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http://dx.doi.org/10.2147/IJGM.S136153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993036PMC
June 2018
7 Reads

Overview of air pollution and endocrine disorders.

Int J Gen Med 2018 23;11:191-207. Epub 2018 May 23.

School of Biological Sciences, University of Reading, Reading, UK.

Over recent years, many environmental pollutant chemicals have been shown to possess the ability to interfere in the functioning of the endocrine system and have been termed endocrine disrupting chemicals (EDCs). These compounds exist in air as volatile or semi-volatile compounds in the gas phase or attached to particulate matter. They include components of plastics (phthalates, bisphenol A), components of consumer goods (parabens, triclosan, alkylphenols, fragrance compounds, organobromine flame retardants, fluorosurfactants), industrial chemicals (polychlorinated biphenyls), products of combustion (polychlorinated dibenzodioxins/furans, polyaromatic hydrocarbons), pesticides, herbicides, and some metals. Read More

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http://dx.doi.org/10.2147/IJGM.S102230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973437PMC
May 2018
2 Reads

Exploring factors that might influence primary-care provider discussion of and recommendation for prostate and colon cancer screening.

Int J Gen Med 2018 17;11:179-190. Epub 2018 May 17.

Reaching for High Value Care Team, Chapel Hill, NC, USA.

Background: Primary-care providers may contribute to the use of low-value cancer screening.

Objective: We sought to examine circumstances under which primary-care providers would discuss and recommend two types of cancer screening services across a spectrum of net benefit and other factors known to influence screening.

Patients And Methods: This was a cross sectional survey of 126 primary-care providers in 24 primary-care clinics in the US. Read More

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http://dx.doi.org/10.2147/IJGM.S153887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962312PMC
May 2018
3 Reads

Remote ischemic preconditioning in myocardial protection in hemodialysis patients.

Int J Gen Med 2018 8;11:175-178. Epub 2018 May 8.

Clinical Analysis Laboratory of Faculdade de Medicina do ABC, Santo André, SP, Brazil.

Background: Remote ischemic preconditioning (RIPC) is a procedure that generates a brief period of ischemia followed by reperfusion. The role of RIPC in protecting myocardial ischemia during hemodialysis is not yet established. The aim of the study was to evaluate RIPC myocardial protection as evaluated by ultrasensitive I troponin in hemodialysis outpatients. Read More

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http://dx.doi.org/10.2147/IJGM.S144385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947106PMC
May 2018
18 Reads

An echo to Choosing Wisely in Switzerland.

Int J Gen Med 2018 4;11:167-174. Epub 2018 May 4.

Department of Internal Medicine, Medical Clinic, Hospital Uster, Uster, Switzerland.

Background: Inspired by the US Choosing Wisely, in 2016 the Swiss Society of General Internal Medicine released a list of five treatments or diagnostic tests used in the hospital and considered unnecessary based on not improving patient care and adding to health care costs. These "Smarter Medicine" recommendations were implemented in the Department of Internal Medicine, Uster Hospital, in August 2016. They were supported by lectures and weekly email communications. Read More

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https://www.dovepress.com/an-echo-to-choosing-wiselyreg-in-s
Publisher Site
http://dx.doi.org/10.2147/IJGM.S155544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942164PMC
May 2018
4 Reads

The vitamin D receptor and the etiology of RANTES/CCL-expressive fatty-degenerative osteolysis of the jawbone: an interface between osteoimmunology and bone metabolism.

Int J Gen Med 2018 27;11:155-166. Epub 2018 Apr 27.

Statistics at Institute for Epidemiological Studies, Berlin, Germany.

Background: Recent research on vitamin D indicates that our current understanding of the factors leading to chronic inflammation should be revised. One of the key mechanisms by which microbial immunosuppression occurs is the suppression of one of the most common endogenous cell nucleus receptors: the vitamin D receptor (VDR). Autoimmune diseases may be correlated with VDR deactivation (VDR-deac) which occurs when the receptor is no longer able to transcribe antimicrobial agents. Read More

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http://dx.doi.org/10.2147/IJGM.S152873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927352PMC
April 2018
1 Read

Nephritis, cerebritis, and myositis after adalimumab therapy in a patient with rheumatoid arthritis: a case report.

Int J Gen Med 2018 11;11:151-154. Epub 2018 Apr 11.

Department of Internal Medicine and Rheumatology, Umm Al Qura University Hospital, Makkah, Saudi Arabia.

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that mainly affects the joints, therefore, may cause deformities and disability if untreated. The first line of treatment is disease-modifying antirheumatic drugs (DMARDs). When the patient fails to respond to DMARDs, mainly methotrexate, then second-line therapy is required. Read More

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http://dx.doi.org/10.2147/IJGM.S154835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903491PMC
April 2018
6 Reads