1,500 results match your criteria International Journal of Endocrinology [Journal]


Primary Tumor Site Affects Survival in Patients with Gastroenteropancreatic and Neuroendocrine Liver Metastases.

Int J Endocrinol 2019 12;2019:9871319. Epub 2019 Mar 12.

Division of General Surgery, Department of Surgery, The University of Chicago Medical Center, Chicago, IL, USA.

Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are commonly present with metastatic disease, and the liver is the most frequent metastatic site. Herein, we studied whether primary tumor site affects survival in patients with GEP-NETs and liver metastases (NELM). As a secondary endpoint, we studied whether extrahepatic disease and surgical resection impact survival in this patient population. Read More

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https://www.hindawi.com/journals/ije/2019/9871319/
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http://dx.doi.org/10.1155/2019/9871319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434277PMC
March 2019
1 Read

Gut Microbiota Composition and Structure of the Ob/Ob and Db/Db Mice.

Int J Endocrinol 2019 11;2019:1394097. Epub 2019 Mar 11.

Institute of Neuroscience and Translational Medicine, College of Life Science and Agronomy, Zhoukou Normal University, Zhoukou, Henan 466001, China.

Introduction: Gut microbiota is involved in the progression of metabolic diseases such as obesity and type 2 diabetes. The ob/ob and db/db mice are extensively used as models in studies on the pathogenesis of these diseases. The goal of this study is to characterize the composition and structure of gut microbiota in these model mice at different ages. Read More

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https://www.hindawi.com/journals/ije/2019/1394097/
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http://dx.doi.org/10.1155/2019/1394097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432735PMC
March 2019
2 Reads

Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture.

Int J Endocrinol 2019 6;2019:6782653. Epub 2019 Mar 6.

Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, 87# Xiangya Road, Changsha, Hunan 410008, China.

Emerging evidence demonstrates that microRNAs, as important endogenous posttranscriptional regulators, are essential for bone remodeling and regeneration. Undoubtedly, microRNA-based gene therapies show great potential to become novel approaches against bone-related diseases, including osteoporosis and associated fractures. The major obstacles for continued advancement of microRNA-based therapies in clinical application include their poor stability, nonspecific biodistribution, and unwanted side effects. Read More

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http://dx.doi.org/10.1155/2019/6782653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431398PMC
March 2019
1 Read

Correlation of Serum 1,5-AG with Uric Acid in Type 2 Diabetes Mellitus with Different Renal Functions.

Int J Endocrinol 2019 6;2019:4353075. Epub 2019 Mar 6.

Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu Province, China.

Aim: Recent studies found that levels of serum uric acid (SUA) were positively associated with serum 1,5-anhydroglucitol (1,5-AG) in subjects with type 2 diabetes mellitus (T2DM). In the current study, we investigated the association between 1,5-AG and UA in T2DM patients with different renal functions.

Methods: A total of 405 T2DM patients, 213 men and 192 women, participated in the study. Read More

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https://www.hindawi.com/journals/ije/2019/4353075/
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http://dx.doi.org/10.1155/2019/4353075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431393PMC
March 2019
2 Reads

Gender- and Age-Specific Differences in the Association of Hyperuricemia and Hypertension: A Cross-Sectional Study.

Int J Endocrinol 2019 28;2019:7545137. Epub 2019 Feb 28.

Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.

Objective: Both hyperuricemia and hypertension have important clinical implications, but their relationship in terms of gender and age is still a matter of debate. In this study, we aimed to explore gender- and age-specific differences in this association between hyperuricemia and hypertension in a Chinese population.

Methods: A total of 78596 ostensibly healthy subjects (47781 men and 30815 women) were recruited. Read More

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http://dx.doi.org/10.1155/2019/7545137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421730PMC
February 2019
2 Reads

Acute Postexercise Change in Circulating Irisin Is Related to More Favorable Lipid Profile in Pregnant Women Attending a Structured Exercise Program and to Less Favorable Lipid Profile in Controls: An Experimental Study with Two Groups.

Int J Endocrinol 2019 28;2019:1932503. Epub 2019 Feb 28.

Department of Physiology and Pharmacology, Gdansk University of Physical Education and Sport, Gdansk, Poland.

Introduction: The blood irisin concentrations may be affected both by exercise and pregnancy. We aimed to determine acute responses in serum irisin after a single exercise session and relationships between exercise-induced changes in this hormone and lipid profile in pregnancy.

Material And Methods: It was an experimental study in 20 Caucasian women in normal pregnancy (age 30 ± 3 years, 28 ± 6 weeks of gestation; mean ± SD). Read More

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http://dx.doi.org/10.1155/2019/1932503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421761PMC
February 2019
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Genetic, Functional, and Immunological Study of ZnT8 in Diabetes.

Int J Endocrinol 2019 26;2019:1524905. Epub 2019 Feb 26.

Department of Pharmacy, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

Zinc level in the body is finely regulated to maintain cellular function. Dysregulation of zinc metabolism may induce a variety of diseases, e.g. Read More

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https://www.hindawi.com/journals/ije/2019/1524905/
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http://dx.doi.org/10.1155/2019/1524905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413397PMC
February 2019
2 Reads

Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies.

Int J Endocrinol 2019 20;2019:9626715. Epub 2019 Feb 20.

Department of Medical Physics, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Poland.

Melatonin may serve as a potential therapeutic free radical scavenger and broad-spectrum antioxidant. It shows neuroprotective properties against hypoxic-ischemic brain injury in animal models. The authors review the studies focusing on the neuroprotective potential of melatonin and its possibility of treatment after perinatal asphyxia. Read More

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http://dx.doi.org/10.1155/2019/9626715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402213PMC
February 2019
1 Read

Glucocorticoid Receptor Antagonist Administration Prevents Adrenal Gland Atrophy in an ACTH-Independent Cushing's Syndrome Rat Model.

Int J Endocrinol 2019 19;2019:8708401. Epub 2019 Feb 19.

Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa 259-1193, Japan.

ACTH-independent Cushing's syndrome (CS) is mainly caused by cortisol-secreting adrenocortical tumours. It is well known that secondary adrenal insufficiency occurs after surgical resection of these tumours. In this regard, impaired adrenocortical function is likely induced by atrophy of the residual adrenal tissue as a result of chronic suppression by the low ACTH levels of the hypercortisolism state. Read More

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http://dx.doi.org/10.1155/2019/8708401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399522PMC
February 2019
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An Update of the Appropriate Treatment Strategies in Anaplastic Thyroid Cancer: A Population-Based Study of 735 Patients.

Int J Endocrinol 2019 19;2019:8428547. Epub 2019 Feb 19.

Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

Background: Anaplastic thyroid cancer (ATC) responds poorly to conventional therapies and requires a multidisciplinary approach to manage. The aim of the current study is to explore whether aggressive treatment is beneficial, especially the appropriate extent of surgery in ATC.

Methods: Patients diagnosed with ATC from 2004 to 2014 were identified from the Surveillance, Epidemiology, and End Results (SEER) database and included in our study. Read More

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http://dx.doi.org/10.1155/2019/8428547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399533PMC
February 2019
1 Read

Expression of PAPP-A2 and IGF Pathway-Related Proteins in the Hip Joint of Normal Rat and Those with Developmental Dysplasia of the Hip.

Int J Endocrinol 2019 20;2019:7691531. Epub 2019 Feb 20.

Department of Pediatric Orthopedics, Shengjing Hospital of China Medical University, Shenyang City 110004, China.

Developmental dysplasia of the hip (DDH) is one of the major causes of child disability and early osteoarthritis. Genetic factors play an important role, but which still remain unclear. Pregnancy-associated plasma protein-A2 (PAPP-A2), a special hydrolase of insulin-like growth factor binding protein-5 (IGFBP-5), has been confirmed to be associated with DDH by previous studies. Read More

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http://dx.doi.org/10.1155/2019/7691531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402211PMC
February 2019

Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing's Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China.

Int J Endocrinol 2019 19;2019:7159696. Epub 2019 Feb 19.

Key Laboratory of Endocrinology of National Health Commission of People's Republic of China, Beijing 100730, China.

Purpose: To investigate the demographic characteristics, etiology, and comorbidities of Cushing's syndrome (CS) patients at a large medical center in China.

Methods: Records on CS patients discharged from 2008 to 2017 were retrieved from the hospital discharge abstract database (DAD) using ICD-10 codes. Demographic characteristics, etiology, and comorbidity data were analyzed. Read More

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http://dx.doi.org/10.1155/2019/7159696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399544PMC
February 2019
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Precise Detection of Gene Mutations in Fine-Needle Aspiration Specimens of the Papillary Thyroid Microcarcinoma Using Next-Generation Sequencing.

Int J Endocrinol 2019 19;2019:4723958. Epub 2019 Feb 19.

Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Purpose: To assess the feasibility of next-generation sequencing (NGS) to detect mutations in BRAF, RAS, TERT promoter, and TP53 genes in ultrasound-guided fine-needle aspiration (FNA) biopsy samples of the papillary thyroid microcarcinoma (PTMC).

Methods: A total of 135 FNA samples out of 135 patients with suspected PTMC were submitted for mutation testing using NGS. NGS was successfully performed in 114 specimens, while the remaining 21 samples were excluded due to insufficient amount/poor quality of DNA and sequencing failure. Read More

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http://dx.doi.org/10.1155/2019/4723958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399538PMC
February 2019
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Serum Thyroglobulin: Preoperative Levels and Factors Affecting Postoperative Optimal Timing following Total Thyroidectomy.

Int J Endocrinol 2019 20;2019:1384651. Epub 2019 Feb 20.

Department of Internal Medicine, Division of Diabetes, Endocrine and Metabolism, University of Nebraska Medical Center, Omaha, NE, USA.

Objective: We evaluated if preoperative TG levels affected postoperative levels and if other factors may influence the optimal time to check postoperative TG.

Methods: This is a prospective, observational pilot study. We approved and enrolled 50 subjects ≥ 19 years scheduled for total thyroidectomy and measured serum TG, thyroglobulin antibody (TG ab), and TSH preoperatively and post thyroidectomy at 7-14 days, 4 and 6 weeks, and 3 months in subjects with benign pathology, with additional 6- and 12-month measurements in subjects with thyroid cancer. Read More

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http://dx.doi.org/10.1155/2019/1384651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402205PMC
February 2019
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Novel Prognostic Factors Associated with Cell Cycle Control in Sporadic Medullary Thyroid Cancer Patients.

Int J Endocrinol 2019 18;2019:9421079. Epub 2019 Feb 18.

Endocrinology Unit, Department of Medicine (DIMED), University of Padova, Via Ospedale 105, Padova 35128, Italy.

Background: Medullary thyroid cancer (MTC) is a rare neuroendocrine-derived malignancy. It is represented by sporadic and familiar forms, and both can have oncogene mutations. Numerous markers can be used to define MTC; however, none is generally approved for predicting the outcome of sporadic MTC. Read More

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http://dx.doi.org/10.1155/2019/9421079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398011PMC
February 2019
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Expression of Leptin Receptor and Effects of Leptin on Papillary Thyroid Carcinoma Cells.

Int J Endocrinol 2019 14;2019:5031696. Epub 2019 Feb 14.

Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.

Background: Obesity has been hypothesized to contribute to the aggressiveness of thyroid cancer through the production of abnormal levels of serum adipokines. Leptin receptor (OB-R) expression has also been documented in papillary thyroid cancer (PTC).

Aim: In this translational study, we analyzed the effects of leptin on the growth and migration of thyroid cancer cells (TPC-1 and K1), the molecular mechanisms underlying leptin's action, and the influence of prolonged leptin exposure on cell response to a protein kinase inhibitor lenvatinib. Read More

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http://dx.doi.org/10.1155/2019/5031696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393892PMC
February 2019
1 Read

Hypertriglyceridemia and Its Association with HbA1c Test: A Prospective Controlled Study.

Int J Endocrinol 2019 12;2019:4784313. Epub 2019 Feb 12.

University Hospital "Dr. Jose E. Gonzalez, " Universidad Autonoma de Nuevo Leon, Endocrinology Division, Department of Internal Medicine, Monterrey 64460, Mexico.

Background: Hypertriglyceridemia and hyperglycemia coexist in 30-60% of patients with diabetes. The impact of hypertriglyceridemia regarding HbA1c assay reliability remains uncertain. Therefore, we conducted a prospective controlled study with the aim of defining the association between triglyceride levels and HbA1c. Read More

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http://dx.doi.org/10.1155/2019/4784313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390253PMC
February 2019
3 Reads

Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study.

Int J Endocrinol 2019 6;2019:9802827. Epub 2019 Feb 6.

CNR-Regione Toscana G Monasterio Foundation, Pisa, Italy.

Purpose: Oral bisphosphonates (BPs) are the most commonly used medications for osteoporosis (OP), but their poor gastrointestinal (GI) absorption and tolerance hamper compliance. Intramuscular (IM) neridronate (NE), an amino-BP, is an easy-to-administer, effective, and safe alternative to oral BPs. We assessed the 6-year effects of monthly IM NE on bone mineral density (BMD) and bone turnover biomarkers (BMs) in postmenopausal OP. Read More

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http://dx.doi.org/10.1155/2019/9802827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381585PMC
February 2019
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Study of the Potential Endocrine-Disrupting Effects of Phenylurea Compounds on Neurohypophysis Cells .

Int J Endocrinol 2019 10;2019:1546131. Epub 2019 Feb 10.

Institute of Applied Science, Department of Environmental Biology and Education, Gyula Juhász Faculty of Education, University of Szeged, Szeged, Hungary.

Homeostatic disruptor agents, and endocrine disruptor compounds (EDC) specifically, can originate from agricultural and industrial chemicals. If they modify the adaptation of living organisms as direct (e.g. Read More

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http://dx.doi.org/10.1155/2019/1546131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387713PMC
February 2019
1 Read

Corrigendum to "Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects".

Int J Endocrinol 2019 29;2019:9131406. Epub 2019 Jan 29.

Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

[This corrects the article DOI: 10.1155/2017/8401518.]. Read More

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http://dx.doi.org/10.1155/2019/9131406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374876PMC
January 2019
2 Reads

A Novel Pentapeptide Inhibitor Reduces Amyloid Deposit Formation by Direct Interaction with hIAPP.

Int J Endocrinol 2019 29;2019:9062032. Epub 2019 Jan 29.

Hepatobiliary Surgery Department and Unit of Organ Transplantation, The First Hospital of China Medical University, Shenyang 110001, China.

Backgrounds: The presence of amyloid deposits of human islet amyloid polypeptide (hIAPP) in islet -cells has been associated with type 2 diabetes occurrence and islet graft failure. Self-assembly into oligomers and fibrils during the process of aggregation by hIAPP can lead to failure and depletion of -cells. Studies have shown that some critical regions of hIAPP might contribute to the aggregation. Read More

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http://dx.doi.org/10.1155/2019/9062032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374824PMC
January 2019
5 Reads

Association between the Number of Childbirths and the Progress of Atherosclerosis among Women with Diabetes: A Cohort Study Based on Chinese Population.

Int J Endocrinol 2019 27;2019:4874121. Epub 2019 Jan 27.

School of Medicine, Nankai University, Tianjin, China.

Background: The aim of this study is to explore the association between the number of childbirths and the progress of atherosclerosis among Chinese women with hypertension or diabetes.

Methods: In total, 1159 Chinese parous women from a community longitudinal survey conducted in the communities of Shijingshan district, Beijing, China, were included in our study. They were divided into three groups according to the number of childbirths, and the change in pulse wave velocity (PWV) was as an indicator of the progression of atherosclerosis because the increased PWV reflected the more serious atherosclerosis. Read More

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http://dx.doi.org/10.1155/2019/4874121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369472PMC
January 2019
3 Reads

Vitamin D and Dental Caries in Children with Growth Hormone Deficiency.

Int J Endocrinol 2019 21;2019:2172137. Epub 2019 Jan 21.

Department of Paediatric Endocrinology and Diabetology with Endocrine-Metabolic Laboratory, Medical University of Lublin, Poland.

Vitamin D deficiency is a common risk factor for multifactorial diseases, and it seems to be associated with growth hormone deficiency (GHD). Vitamin D could prevent dental caries. The goal of this study was to identify whether there is an association between hormonal therapy with growth hormone (GH), vitamin D supplementation, vitamin D levels, and the occurrence of caries among children affected by GHD. Read More

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http://dx.doi.org/10.1155/2019/2172137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360574PMC
January 2019

Relation of Different Components of Climate with Human Pituitary-Thyroid Axis and FT3/FT4 Ratio: A Study on Euthyroid and SCH Subjects in Two Different Seasons.

Int J Endocrinol 2019 16;2019:2762978. Epub 2019 Jan 16.

Physiology Department, College of Medicine, University of Sulaimani, Sulaymaniyah 46001, Iraq.

Background: Various changes in thyroid hormones (TH) and thyroid-stimulating hormone (TSH) level were observed in different seasons among euthyroid and hypothyroid subjects living in areas with an extreme temperature difference between summer and winter.

Objectives: This study aims at finding the effect of temperate climate on the seasonal variations of TSH and TH in euthyroid and subclinical hypothyroidism (SCH) subjects and at evaluating if the test season has an effect on the number of subjects diagnosed as SCH. It basically focuses on the relation of different components of climate with TH and TSH. Read More

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http://dx.doi.org/10.1155/2019/2762978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360063PMC
January 2019

Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas.

Int J Endocrinol 2019 13;2019:9651380. Epub 2019 Jan 13.

Department of General Surgery, Xuhui District Central Hospital of Shanghai, Shanghai 200031, China.

Anaplastic thyroid carcinoma (ATC) is a very rare malignancy; the pathogenesis of which is still not fully understood. The aim of the present study was to identify hub genes and pathways in ATC by microarray expression profiling. Two independent datasets (GSE27155 and GSE53072) were downloaded from GEO database. Read More

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http://dx.doi.org/10.1155/2019/9651380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350566PMC
January 2019
2 Reads

Clinical Usefulness of Bioavailable Vitamin D and Impact of Genotyping on the Determination of Bioavailable Vitamin D in a Korean Population.

Int J Endocrinol 2019 13;2019:9120467. Epub 2019 Jan 13.

Department of Laboratory Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.

Background: Bioavailable 25-hydroxy vitamin D (25(OH)D) has been suggested for the accurate determination of vitamin D status. The purpose of this study was to determine the utility of bioavailable 25(OH)D in assessing vitamin D status when vitamin D-binding protein (VDBP) was significantly altered by pregnancy and liver cirrhosis (LC). The role of genotyping of , a gene encoding VDBP, in the determination of bioavailable 25(OH)D concentration in a Korean population was also evaluated. Read More

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http://dx.doi.org/10.1155/2019/9120467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350553PMC
January 2019

Risk Factors for Cervical Lymph Node Metastasis of Papillary Thyroid Microcarcinoma: A Single-Center Retrospective Study.

Int J Endocrinol 2019 15;2019:8579828. Epub 2019 Jan 15.

Department of Thyroid and Breast Surgery, Lishui Hospital of Zhejiang University, Lishui Municipal Central Hospital, Lishui 323000, China.

Objective: To identify the clinicopathological features correlated to lymph node metastasis (LNM) in patients with papillary thyroid microcarcinoma (PTMC).

Methods: Clinical data of 785 PTMC patients who underwent surgical treatment at the Lishui Municipal Central Hospital from September 2008 to December 2017 were retrospectively analyzed. Clinical and pathological risk factors for lymph node metastasis (LNM), central lymph node metastasis (CLNM), and lateral lymph node metastasis (LLNM) were analyzed. Read More

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http://dx.doi.org/10.1155/2019/8579828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350584PMC
January 2019
1 Read

Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis.

Int J Endocrinol 2019 10;2019:7570146. Epub 2019 Jan 10.

Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.

Background And Aims: Hepatocellular carcinoma (HCC) is the common tumor of the liver. Unfortunately, most HCC seem to be resistant to conventional chemotherapy and radiotherapy. The poor efficacy of antitumor agents is also due, at least in part, to the inefficient drug delivery and metabolism exerted by the steatotic/cirrhotic liver that hosts the tumor. Read More

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http://dx.doi.org/10.1155/2019/7570146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350585PMC
January 2019

Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves' Ophthalmopathy.

Int J Endocrinol 2019 15;2019:7429187. Epub 2019 Jan 15.

Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, No. 1500 Zhouyuan Road, Pudong District, Shanghai 201318, China.

The objective of this study was to investigate whether polymorphisms are associated with autoimmune thyroid diseases (AITDs). We selected three single nucleotide polymorphisms (SNPs) of , namely, rs1061501, rs1131665, and rs1061502 for genotyping using PCR-based ligase detection reaction (LDR) method in a total of 1659 participants (592 with Graves' disease, 297 with Hashimoto's thyroiditis, and 770 healthy controls). Gene-disease and genotype-clinical phenotype associations were evaluated for the three SNPs. Read More

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http://dx.doi.org/10.1155/2019/7429187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350596PMC
January 2019
3 Reads

PDE5A Suppresses Proteasome Activity Leading to Insulin Resistance in C2C12 Myotubes.

Int J Endocrinol 2019 15;2019:3054820. Epub 2019 Jan 15.

Department of Pathology and Pathophysiology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071 Hubei, China.

Objective: The involvement of phosphodiesterase type 5 (PDE5) in the development of insulin resistance has been reported recently. However, the underlying molecular mechanism remains unclear. The present study aims at investigating the potential impacts of PDE5A on insulin signaling in C2C12 skeletal muscle myotubes and uncover the related mechanism. Read More

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http://dx.doi.org/10.1155/2019/3054820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350610PMC
January 2019
2 Reads

Early Effects of Hyperbaric Oxygen on Inducible Nitric Oxide Synthase Activity/Expression in Lymphocytes of Type 1 Diabetes Patients: A Prospective Pilot Study.

Int J Endocrinol 2019 10;2019:2328505. Epub 2019 Jan 10.

Institute of Nuclear Sciences Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, Belgrade, Serbia.

This study aimed at examining the early effects of hyperbaric oxygen therapy (HBOT) on inducible nitric oxide synthase (iNOS) activity/expression in lymphocytes of type 1 diabetes mellitus (T1DM) patients. A group of 19 patients (mean age: 63 ± 2.1) with T1DM and with the peripheral arterial disease were included in this study. Read More

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http://dx.doi.org/10.1155/2019/2328505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348926PMC
January 2019
1.515 Impact Factor

Aerobic Training Associated with Arginine Supplementation Reduces Collagen-Induced Platelet Hyperaggregability in Rats under High Risk to Develop Metabolic Syndrome.

Int J Endocrinol 2019 6;2019:8919435. Epub 2019 Jan 6.

Laboratory of Experimental Pharmacology (LAFE), Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University (UFF), Room 204-A, 24420-210 Niterói, RJ, Brazil.

Background: Increased platelet response is seen in individuals with metabolic syndrome. Previous reports have shown that arginine supplementation and aerobic exercise training enhance vascular nitric oxide (NO) activity and inhibit platelet hyperaggregability; however, the effects of their association remain unknown.

Aim: To investigate whether arginine supplementation and aerobic exercise association may exert beneficial effects, reducing platelet hyperaggregability in rats under high risk to develop metabolic syndrome. Read More

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http://dx.doi.org/10.1155/2019/8919435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339713PMC
January 2019
2 Reads

Animal Models of Diabetes and Related Metabolic Diseases.

Int J Endocrinol 2019 6;2019:6147321. Epub 2019 Jan 6.

Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT, USA.

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http://dx.doi.org/10.1155/2019/6147321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339747PMC
January 2019
1 Read
1.515 Impact Factor

Is a Combination of a GnRH Agonist and Recombinant Growth Hormone an Effective Treatment to Increase the Final Adult Height of Girls with Precocious or Early Puberty?

Int J Endocrinol 2018 30;2018:1708650. Epub 2018 Dec 30.

Department of Pediatrics, The Second Hospital of Shandong University, Jinan, Shandong Province, China.

The aim of treatment for idiopathic central precocious puberty (ICPP) is to increase final adult stature, for which gonadotropin-releasing hormone agonist (GnRHa) is the gold standard. Early puberty is frequently similar to ICPP, with pubertal onset only slightly advanced. Short stature may result from early pubertal onset. Read More

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https://www.hindawi.com/journals/ije/2018/1708650/
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http://dx.doi.org/10.1155/2018/1708650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332953PMC
December 2018
3 Reads

Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes.

Int J Endocrinol 2018 24;2018:7918714. Epub 2018 Dec 24.

Division of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of Korea.

Background: Previous studies have suggested the existence of distinct body size subgroups according to metabolic health referred to as metabolically healthy obesity (MHO) and metabolically abnormal but normal weight (MANW) patients. Although nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity and metabolic syndrome, the relationship between these phenotypes and fetuin-A, a representative hepatokine, has not been explored.

Methods: We examined the association between circulating fetuin-A levels, metabolic health phenotypes, cardiometabolic risk parameters, and subclinical atherosclerosis in 290 subjects who were randomly selected from an ongoing cohort study. Read More

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http://dx.doi.org/10.1155/2018/7918714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323440PMC
December 2018

Nerve Growth Factor Levels in Term Human Infants: Relationship to Prenatal Growth and Early Postnatal Feeding.

Int J Endocrinol 2018 23;2018:7562702. Epub 2018 Dec 23.

Institut de Recerca Pediàtrica Hospital Sant Joan de Déu (IRP-HSJD), University of Barcelona, 08950 Esplugues, Barcelona, Spain.

Background: Nerve growth factor (NGF) plays a key role in neuroprotection and developmental maturity. We assessed longitudinally the circulating concentrations of NGF in term healthy human newborns and infants as well as their association with prenatal growth and early postnatal feeding patterns.

Methods: Circulating NGF and anthropometric measures (weight, length, body mass index, and ponderal index) were assessed longitudinally-at birth and at age 4 months-in 86 term infants born appropriate (AGA), small (SGA), or large for gestational age (LGA). Read More

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http://dx.doi.org/10.1155/2018/7562702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323468PMC
December 2018
1 Read

Vanadyl Sulfate Effects on Systemic Profiles of Metabolic Syndrome in Old Rats with Fructose-Induced Obesity.

Int J Endocrinol 2018 25;2018:5257216. Epub 2018 Dec 25.

Renal PathophysiologyLaboratory, Department of Nephrology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico City, Mexico.

Background: Currently, energy obtained from hypercaloric diets has been part of the obesity and type 2 diabetes mellitus (T2DM) epidemics from childhood to old age. Treatment alternatives have been sought from plants, minerals, and trace elements with metabolic effects. Vanadyl sulfate (VS) has been investigated as a hypoglycemic compound in animal and human studies showing effective insulin-mimetic properties. Read More

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http://dx.doi.org/10.1155/2018/5257216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323508PMC
December 2018
2 Reads

Characterization of Follicular Atresia Responsive to BPA in Zebrafish by Morphometric Analysis of Follicular Stage Progression.

Int J Endocrinol 2018 23;2018:4298195. Epub 2018 Dec 23.

Dipartimento di Medicina Sperimentale, Sez. Bottazzi, Università degli Studi della Campania "L. Vanvitelli", Via Costantinopoli 16, 80138 Napoli, Italy.

Bisphenol A is an industrial chemical compound, pervasively polluting the environment and diet, classified as an endocrine disruptor because of its interference effects on the endocrine system. In zebrafish, BPA exposure induces follicular atresia. To acquire knowledge on this atretic effect, using a qualitative and quantitative histomorphological approach, we studied zebrafish ovarian follicular stage development in response to low BPA concentrations. Read More

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http://dx.doi.org/10.1155/2018/4298195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323489PMC
December 2018

Thyroid Dysfunction in Patients with Metabolic Syndrome: A Cross-Sectional, Epidemiological, Pan-India Study.

Int J Endocrinol 2018 25;2018:2930251. Epub 2018 Dec 25.

Abbott India Ltd, Mumbai, India.

Background: This study was conducted to assess the prevalence and clinical and epidemiological factors of thyroid dysfunction (TD) in Indian patients diagnosed with metabolic syndrome (MetS).

Methods: In this cross-sectional study, 432 adults with an established diagnosis of MetS were enrolled across ten centers in India. Anthropometric measurements and vital signs were noted. Read More

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http://dx.doi.org/10.1155/2018/2930251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323507PMC
December 2018
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The Association between Glucose Control and Functional Indices in Older People with Diabetes.

Int J Endocrinol 2018 23;2018:1053815. Epub 2018 Dec 23.

The "Segal" Center for Successful Aging with Diabetes, Endocrinology Institute, Sheba Medical Center, Israel.

Diabetes may be viewed as a disease of accelerated aging as it is a risk factor for physical disability and impairment in simple and complex activities, and is a higher risk for falls and fractures. Data from the last several years suggests that this increased risk is due not only to recognized diabetes complications but also to an accelerated decline in physical capacity due to lower muscle quality and a more rapid decline in muscle mass and lower extremity strength over time. . Read More

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http://dx.doi.org/10.1155/2018/1053815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323481PMC
December 2018

Response to: Comment on "The Gut Microbiome Profile in Obesity: A Systematic Review".

Int J Endocrinol 2018 20;2018:9109451. Epub 2018 Dec 20.

Cardiovascular Risk and Nutrition Research Group of IMIM-Hospital del Mar Research Institute, Barcelona, Spain.

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http://dx.doi.org/10.1155/2018/9109451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317104PMC
December 2018

Hepatic Steatosis Index in Acromegaly: Correlation with Insulin Resistance Regardless of the Disease Control.

Int J Endocrinol 2018 19;2018:5421961. Epub 2018 Dec 19.

Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy.

Objective: In acromegaly, both lipotoxicity secondary to GH excess and insulin resistance have a significant impact on the liver. Ultrasonography has shown poor sensitivity in detecting hepatic steatosis and noninvasive methods have been proposed. We evaluated the hepatic steatosis index (HSI), a validated surrogate index of hepatic steatosis, and we correlated it with disease activity and insulin resistance. Read More

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https://www.hindawi.com/journals/ije/2018/5421961/
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http://dx.doi.org/10.1155/2018/5421961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313980PMC
December 2018
10 Reads

Autoimmune Diseases in Patients with Cushing's Syndrome after Resolution of Hypercortisolism: Case Reports and Literature Review.

Int J Endocrinol 2018 18;2018:1464967. Epub 2018 Dec 18.

Secondary Hypertension Unit, Department of Transactional Medicine and Precision, University of Rome "La Sapienza", Rome, Italy.

Introduction: Cushing's syndrome (CS) is a clinical condition characterized by excessive cortisol production, associated with metabolic complications, such as diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, and cardiovascular diseases. Nowadays, the occurrence of autoimmune diseases in CS have not been completely evaluated in the previous studies.

Objective: The aim of this study was to evaluate the occurrence of autoimmune diseases in CS patients after successfully treated. Read More

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http://dx.doi.org/10.1155/2018/1464967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312625PMC
December 2018
15 Reads
1.515 Impact Factor

Metabolic Syndrome and Its Components Predict the Risk of Type 2 Diabetes Mellitus in the Mainland Chinese: A 3-Year Cohort Study.

Int J Endocrinol 2018 13;2018:9376179. Epub 2018 Dec 13.

Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Introduction: It has well established that metabolic syndrome (MetS) can predict the risk of type 2 diabetes mellitus (T2DM) in some population groups. However, limited evidence is available regarding the predictive effect of MetS for incident T2DM in mainland Chinese population.

Methods: A 3-year cohort study was performed for 9735 Chinese without diabetes at baseline. Read More

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http://dx.doi.org/10.1155/2018/9376179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311882PMC
December 2018
9 Reads
1.515 Impact Factor

Clinical Diagnosis of X-Linked Spondyloepiphyseal Dysplasia Tarda and a Novel Missense Mutation in the Sedlin Gene (SEDL).

Int J Endocrinol 2018 10;2018:8263136. Epub 2018 Dec 10.

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, China.

Objective: Spondyloepiphyseal dysplasia tarda (SEDT) is a rare hereditary bone disease characterized by spinal and epiphyseal anomalies. We identified the disease by gene sequencing in a Chinese pedigree with SEDT.

Methods: We extracted genomic DNA from five members of a four-generation Chinese SEDT kindred with three affected males and then analyzed the genetic mutation by PCR and DNA sequencing. Read More

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https://www.hindawi.com/journals/ije/2018/8263136/
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http://dx.doi.org/10.1155/2018/8263136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311833PMC
December 2018
12 Reads

A Dipeptidyl Peptidase-4 Inhibitor Suppresses Macrophage Foam Cell Formation in Diabetic Mice and Type 2 Diabetes Patients.

Int J Endocrinol 2018 9;2018:8458304. Epub 2018 Dec 9.

Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Tokyo, Japan.

Dipeptidyl peptidase-4 (DPP-4) inhibitors could have antiatherosclerotic action, in addition to antihyperglycemic roles. Because macrophage foam cells are key components of atherosclerosis, we investigated the effect of the DPP-4 inhibitor teneligliptin on foam cell formation and its related gene expression levels in macrophages extracted from diabetic ( ) mice and type 2 diabetes (T2D) patients ex vivo. We incubated mouse peritoneal macrophages and human monocyte-derived macrophages differentiated by 7-day culture with oxidized low-density lipoprotein in the presence/absence of teneligliptin (10 nmol/L) for 18 hours. Read More

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http://dx.doi.org/10.1155/2018/8458304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304851PMC
December 2018
1 Read

Effects of Vitamin D Supplementation on Glucose and Insulin Homeostasis and Incident Diabetes among Nondiabetic Adults: A Meta-Analysis of Randomized Controlled Trials.

Int J Endocrinol 2018 3;2018:7908764. Epub 2018 Dec 3.

School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China.

Aims: Emerging evidence has suggested a mechanistic link from vitamin D metabolism to glucose and insulin homeostasis. This study is aimed at specifically quantifying the direct effects of vitamin D supplementation on indexes of glucose and insulin homeostasis as well as incidence of type 2 diabetes (T2D) among nondiabetic adults.

Methods: We systematically searched randomized controlled trials (RCTs) of vitamin D supplementation in nondiabetic adults in PubMed, EMBASE, and CENTRAL. Read More

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http://dx.doi.org/10.1155/2018/7908764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304827PMC
December 2018
2 Reads

Liraglutide Enhances the Activity of the ACE-2/Ang(1-7)/Mas Receptor Pathway in Lungs of Male Pups from Food-Restricted Mothers and Prevents the Reduction of SP-A.

Int J Endocrinol 2018 2;2018:6920620. Epub 2018 Dec 2.

Laboratory Endocrinology, LabEndo, Centro de Investigaciones Biomédicas (CINBIO), University of Vigo, E36310 Vigo, Spain.

In utero growth restriction and being born small for gestational age are risk factors for respiratory morbidity. IUGR (in utero growth retardation) is associated to overall reduction in lung weight, surfactant content and activity, impaired maturation of the alveolar type II cells, and decreased alveolar formation. The renin-angiotensin system (RAS) may be a key target underlying pathophysiological lung alterations. Read More

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http://dx.doi.org/10.1155/2018/6920620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304858PMC
December 2018
4 Reads