1,475 results match your criteria International Journal of Endocrinology [Journal]


Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas.

Int J Endocrinol 2019 13;2019:9651380. Epub 2019 Jan 13.

Department of General Surgery, Xuhui District Central Hospital of Shanghai, Shanghai 200031, China.

Anaplastic thyroid carcinoma (ATC) is a very rare malignancy; the pathogenesis of which is still not fully understood. The aim of the present study was to identify hub genes and pathways in ATC by microarray expression profiling. Two independent datasets (GSE27155 and GSE53072) were downloaded from GEO database. Read More

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http://dx.doi.org/10.1155/2019/9651380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350566PMC
January 2019

Clinical Usefulness of Bioavailable Vitamin D and Impact of Genotyping on the Determination of Bioavailable Vitamin D in a Korean Population.

Int J Endocrinol 2019 13;2019:9120467. Epub 2019 Jan 13.

Department of Laboratory Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.

Background: Bioavailable 25-hydroxy vitamin D (25(OH)D) has been suggested for the accurate determination of vitamin D status. The purpose of this study was to determine the utility of bioavailable 25(OH)D in assessing vitamin D status when vitamin D-binding protein (VDBP) was significantly altered by pregnancy and liver cirrhosis (LC). The role of genotyping of , a gene encoding VDBP, in the determination of bioavailable 25(OH)D concentration in a Korean population was also evaluated. Read More

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http://dx.doi.org/10.1155/2019/9120467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350553PMC
January 2019

Risk Factors for Cervical Lymph Node Metastasis of Papillary Thyroid Microcarcinoma: A Single-Center Retrospective Study.

Int J Endocrinol 2019 15;2019:8579828. Epub 2019 Jan 15.

Department of Thyroid and Breast Surgery, Lishui Hospital of Zhejiang University, Lishui Municipal Central Hospital, Lishui 323000, China.

Objective: To identify the clinicopathological features correlated to lymph node metastasis (LNM) in patients with papillary thyroid microcarcinoma (PTMC).

Methods: Clinical data of 785 PTMC patients who underwent surgical treatment at the Lishui Municipal Central Hospital from September 2008 to December 2017 were retrospectively analyzed. Clinical and pathological risk factors for lymph node metastasis (LNM), central lymph node metastasis (CLNM), and lateral lymph node metastasis (LLNM) were analyzed. Read More

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http://dx.doi.org/10.1155/2019/8579828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350584PMC
January 2019

Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis.

Int J Endocrinol 2019 10;2019:7570146. Epub 2019 Jan 10.

Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.

Background And Aims: Hepatocellular carcinoma (HCC) is the common tumor of the liver. Unfortunately, most HCC seem to be resistant to conventional chemotherapy and radiotherapy. The poor efficacy of antitumor agents is also due, at least in part, to the inefficient drug delivery and metabolism exerted by the steatotic/cirrhotic liver that hosts the tumor. Read More

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http://dx.doi.org/10.1155/2019/7570146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350585PMC
January 2019

Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves' Ophthalmopathy.

Int J Endocrinol 2019 15;2019:7429187. Epub 2019 Jan 15.

Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, No. 1500 Zhouyuan Road, Pudong District, Shanghai 201318, China.

The objective of this study was to investigate whether polymorphisms are associated with autoimmune thyroid diseases (AITDs). We selected three single nucleotide polymorphisms (SNPs) of , namely, rs1061501, rs1131665, and rs1061502 for genotyping using PCR-based ligase detection reaction (LDR) method in a total of 1659 participants (592 with Graves' disease, 297 with Hashimoto's thyroiditis, and 770 healthy controls). Gene-disease and genotype-clinical phenotype associations were evaluated for the three SNPs. Read More

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http://dx.doi.org/10.1155/2019/7429187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350596PMC
January 2019
2 Reads

PDE5A Suppresses Proteasome Activity Leading to Insulin Resistance in C2C12 Myotubes.

Int J Endocrinol 2019 15;2019:3054820. Epub 2019 Jan 15.

Department of Pathology and Pathophysiology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071 Hubei, China.

Objective: The involvement of phosphodiesterase type 5 (PDE5) in the development of insulin resistance has been reported recently. However, the underlying molecular mechanism remains unclear. The present study aims at investigating the potential impacts of PDE5A on insulin signaling in C2C12 skeletal muscle myotubes and uncover the related mechanism. Read More

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http://dx.doi.org/10.1155/2019/3054820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350610PMC
January 2019

Early Effects of Hyperbaric Oxygen on Inducible Nitric Oxide Synthase Activity/Expression in Lymphocytes of Type 1 Diabetes Patients: A Prospective Pilot Study.

Int J Endocrinol 2019 10;2019:2328505. Epub 2019 Jan 10.

Institute of Nuclear Sciences Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, Belgrade, Serbia.

This study aimed at examining the early effects of hyperbaric oxygen therapy (HBOT) on inducible nitric oxide synthase (iNOS) activity/expression in lymphocytes of type 1 diabetes mellitus (T1DM) patients. A group of 19 patients (mean age: 63 ± 2.1) with T1DM and with the peripheral arterial disease were included in this study. Read More

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http://dx.doi.org/10.1155/2019/2328505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348926PMC
January 2019

Aerobic Training Associated with Arginine Supplementation Reduces Collagen-Induced Platelet Hyperaggregability in Rats under High Risk to Develop Metabolic Syndrome.

Int J Endocrinol 2019 6;2019:8919435. Epub 2019 Jan 6.

Laboratory of Experimental Pharmacology (LAFE), Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University (UFF), Room 204-A, 24420-210 Niterói, RJ, Brazil.

Background: Increased platelet response is seen in individuals with metabolic syndrome. Previous reports have shown that arginine supplementation and aerobic exercise training enhance vascular nitric oxide (NO) activity and inhibit platelet hyperaggregability; however, the effects of their association remain unknown.

Aim: To investigate whether arginine supplementation and aerobic exercise association may exert beneficial effects, reducing platelet hyperaggregability in rats under high risk to develop metabolic syndrome. Read More

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http://dx.doi.org/10.1155/2019/8919435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339713PMC
January 2019
1 Read

Animal Models of Diabetes and Related Metabolic Diseases.

Int J Endocrinol 2019 6;2019:6147321. Epub 2019 Jan 6.

Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT, USA.

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http://dx.doi.org/10.1155/2019/6147321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339747PMC
January 2019
1.515 Impact Factor

Is a Combination of a GnRH Agonist and Recombinant Growth Hormone an Effective Treatment to Increase the Final Adult Height of Girls with Precocious or Early Puberty?

Int J Endocrinol 2018 30;2018:1708650. Epub 2018 Dec 30.

Department of Pediatrics, The Second Hospital of Shandong University, Jinan, Shandong Province, China.

The aim of treatment for idiopathic central precocious puberty (ICPP) is to increase final adult stature, for which gonadotropin-releasing hormone agonist (GnRHa) is the gold standard. Early puberty is frequently similar to ICPP, with pubertal onset only slightly advanced. Short stature may result from early pubertal onset. Read More

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https://www.hindawi.com/journals/ije/2018/1708650/
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http://dx.doi.org/10.1155/2018/1708650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332953PMC
December 2018
1 Read

Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes.

Int J Endocrinol 2018 24;2018:7918714. Epub 2018 Dec 24.

Division of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of Korea.

Background: Previous studies have suggested the existence of distinct body size subgroups according to metabolic health referred to as metabolically healthy obesity (MHO) and metabolically abnormal but normal weight (MANW) patients. Although nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity and metabolic syndrome, the relationship between these phenotypes and fetuin-A, a representative hepatokine, has not been explored.

Methods: We examined the association between circulating fetuin-A levels, metabolic health phenotypes, cardiometabolic risk parameters, and subclinical atherosclerosis in 290 subjects who were randomly selected from an ongoing cohort study. Read More

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http://dx.doi.org/10.1155/2018/7918714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323440PMC
December 2018

Nerve Growth Factor Levels in Term Human Infants: Relationship to Prenatal Growth and Early Postnatal Feeding.

Int J Endocrinol 2018 23;2018:7562702. Epub 2018 Dec 23.

Institut de Recerca Pediàtrica Hospital Sant Joan de Déu (IRP-HSJD), University of Barcelona, 08950 Esplugues, Barcelona, Spain.

Background: Nerve growth factor (NGF) plays a key role in neuroprotection and developmental maturity. We assessed longitudinally the circulating concentrations of NGF in term healthy human newborns and infants as well as their association with prenatal growth and early postnatal feeding patterns.

Methods: Circulating NGF and anthropometric measures (weight, length, body mass index, and ponderal index) were assessed longitudinally-at birth and at age 4 months-in 86 term infants born appropriate (AGA), small (SGA), or large for gestational age (LGA). Read More

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http://dx.doi.org/10.1155/2018/7562702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323468PMC
December 2018
1 Read

Vanadyl Sulfate Effects on Systemic Profiles of Metabolic Syndrome in Old Rats with Fructose-Induced Obesity.

Int J Endocrinol 2018 25;2018:5257216. Epub 2018 Dec 25.

Renal PathophysiologyLaboratory, Department of Nephrology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico City, Mexico.

Background: Currently, energy obtained from hypercaloric diets has been part of the obesity and type 2 diabetes mellitus (T2DM) epidemics from childhood to old age. Treatment alternatives have been sought from plants, minerals, and trace elements with metabolic effects. Vanadyl sulfate (VS) has been investigated as a hypoglycemic compound in animal and human studies showing effective insulin-mimetic properties. Read More

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http://dx.doi.org/10.1155/2018/5257216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323508PMC
December 2018
1 Read

Characterization of Follicular Atresia Responsive to BPA in Zebrafish by Morphometric Analysis of Follicular Stage Progression.

Int J Endocrinol 2018 23;2018:4298195. Epub 2018 Dec 23.

Dipartimento di Medicina Sperimentale, Sez. Bottazzi, Università degli Studi della Campania "L. Vanvitelli", Via Costantinopoli 16, 80138 Napoli, Italy.

Bisphenol A is an industrial chemical compound, pervasively polluting the environment and diet, classified as an endocrine disruptor because of its interference effects on the endocrine system. In zebrafish, BPA exposure induces follicular atresia. To acquire knowledge on this atretic effect, using a qualitative and quantitative histomorphological approach, we studied zebrafish ovarian follicular stage development in response to low BPA concentrations. Read More

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http://dx.doi.org/10.1155/2018/4298195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323489PMC
December 2018

Thyroid Dysfunction in Patients with Metabolic Syndrome: A Cross-Sectional, Epidemiological, Pan-India Study.

Int J Endocrinol 2018 25;2018:2930251. Epub 2018 Dec 25.

Abbott India Ltd, Mumbai, India.

Background: This study was conducted to assess the prevalence and clinical and epidemiological factors of thyroid dysfunction (TD) in Indian patients diagnosed with metabolic syndrome (MetS).

Methods: In this cross-sectional study, 432 adults with an established diagnosis of MetS were enrolled across ten centers in India. Anthropometric measurements and vital signs were noted. Read More

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http://dx.doi.org/10.1155/2018/2930251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323507PMC
December 2018
2 Reads

The Association between Glucose Control and Functional Indices in Older People with Diabetes.

Int J Endocrinol 2018 23;2018:1053815. Epub 2018 Dec 23.

The "Segal" Center for Successful Aging with Diabetes, Endocrinology Institute, Sheba Medical Center, Israel.

Diabetes may be viewed as a disease of accelerated aging as it is a risk factor for physical disability and impairment in simple and complex activities, and is a higher risk for falls and fractures. Data from the last several years suggests that this increased risk is due not only to recognized diabetes complications but also to an accelerated decline in physical capacity due to lower muscle quality and a more rapid decline in muscle mass and lower extremity strength over time. . Read More

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http://dx.doi.org/10.1155/2018/1053815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323481PMC
December 2018

Response to: Comment on "The Gut Microbiome Profile in Obesity: A Systematic Review".

Int J Endocrinol 2018 20;2018:9109451. Epub 2018 Dec 20.

Cardiovascular Risk and Nutrition Research Group of IMIM-Hospital del Mar Research Institute, Barcelona, Spain.

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http://dx.doi.org/10.1155/2018/9109451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317104PMC
December 2018

Hepatic Steatosis Index in Acromegaly: Correlation with Insulin Resistance Regardless of the Disease Control.

Int J Endocrinol 2018 19;2018:5421961. Epub 2018 Dec 19.

Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy.

Objective: In acromegaly, both lipotoxicity secondary to GH excess and insulin resistance have a significant impact on the liver. Ultrasonography has shown poor sensitivity in detecting hepatic steatosis and noninvasive methods have been proposed. We evaluated the hepatic steatosis index (HSI), a validated surrogate index of hepatic steatosis, and we correlated it with disease activity and insulin resistance. Read More

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https://www.hindawi.com/journals/ije/2018/5421961/
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http://dx.doi.org/10.1155/2018/5421961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313980PMC
December 2018
4 Reads

Autoimmune Diseases in Patients with Cushing's Syndrome after Resolution of Hypercortisolism: Case Reports and Literature Review.

Int J Endocrinol 2018 18;2018:1464967. Epub 2018 Dec 18.

Secondary Hypertension Unit, Department of Transactional Medicine and Precision, University of Rome "La Sapienza", Rome, Italy.

Introduction: Cushing's syndrome (CS) is a clinical condition characterized by excessive cortisol production, associated with metabolic complications, such as diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, and cardiovascular diseases. Nowadays, the occurrence of autoimmune diseases in CS have not been completely evaluated in the previous studies.

Objective: The aim of this study was to evaluate the occurrence of autoimmune diseases in CS patients after successfully treated. Read More

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http://dx.doi.org/10.1155/2018/1464967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312625PMC
December 2018
8 Reads
1.515 Impact Factor

Metabolic Syndrome and Its Components Predict the Risk of Type 2 Diabetes Mellitus in the Mainland Chinese: A 3-Year Cohort Study.

Int J Endocrinol 2018 13;2018:9376179. Epub 2018 Dec 13.

Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Introduction: It has well established that metabolic syndrome (MetS) can predict the risk of type 2 diabetes mellitus (T2DM) in some population groups. However, limited evidence is available regarding the predictive effect of MetS for incident T2DM in mainland Chinese population.

Methods: A 3-year cohort study was performed for 9735 Chinese without diabetes at baseline. Read More

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http://dx.doi.org/10.1155/2018/9376179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311882PMC
December 2018
5 Reads
1.515 Impact Factor

Clinical Diagnosis of X-Linked Spondyloepiphyseal Dysplasia Tarda and a Novel Missense Mutation in the Sedlin Gene (SEDL).

Int J Endocrinol 2018 10;2018:8263136. Epub 2018 Dec 10.

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, China.

Objective: Spondyloepiphyseal dysplasia tarda (SEDT) is a rare hereditary bone disease characterized by spinal and epiphyseal anomalies. We identified the disease by gene sequencing in a Chinese pedigree with SEDT.

Methods: We extracted genomic DNA from five members of a four-generation Chinese SEDT kindred with three affected males and then analyzed the genetic mutation by PCR and DNA sequencing. Read More

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https://www.hindawi.com/journals/ije/2018/8263136/
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http://dx.doi.org/10.1155/2018/8263136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311833PMC
December 2018
6 Reads

A Dipeptidyl Peptidase-4 Inhibitor Suppresses Macrophage Foam Cell Formation in Diabetic Mice and Type 2 Diabetes Patients.

Int J Endocrinol 2018 9;2018:8458304. Epub 2018 Dec 9.

Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Tokyo, Japan.

Dipeptidyl peptidase-4 (DPP-4) inhibitors could have antiatherosclerotic action, in addition to antihyperglycemic roles. Because macrophage foam cells are key components of atherosclerosis, we investigated the effect of the DPP-4 inhibitor teneligliptin on foam cell formation and its related gene expression levels in macrophages extracted from diabetic ( ) mice and type 2 diabetes (T2D) patients ex vivo. We incubated mouse peritoneal macrophages and human monocyte-derived macrophages differentiated by 7-day culture with oxidized low-density lipoprotein in the presence/absence of teneligliptin (10 nmol/L) for 18 hours. Read More

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http://dx.doi.org/10.1155/2018/8458304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304851PMC
December 2018

Effects of Vitamin D Supplementation on Glucose and Insulin Homeostasis and Incident Diabetes among Nondiabetic Adults: A Meta-Analysis of Randomized Controlled Trials.

Int J Endocrinol 2018 3;2018:7908764. Epub 2018 Dec 3.

School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China.

Aims: Emerging evidence has suggested a mechanistic link from vitamin D metabolism to glucose and insulin homeostasis. This study is aimed at specifically quantifying the direct effects of vitamin D supplementation on indexes of glucose and insulin homeostasis as well as incidence of type 2 diabetes (T2D) among nondiabetic adults.

Methods: We systematically searched randomized controlled trials (RCTs) of vitamin D supplementation in nondiabetic adults in PubMed, EMBASE, and CENTRAL. Read More

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http://dx.doi.org/10.1155/2018/7908764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304827PMC
December 2018

Liraglutide Enhances the Activity of the ACE-2/Ang(1-7)/Mas Receptor Pathway in Lungs of Male Pups from Food-Restricted Mothers and Prevents the Reduction of SP-A.

Int J Endocrinol 2018 2;2018:6920620. Epub 2018 Dec 2.

Laboratory Endocrinology, LabEndo, Centro de Investigaciones Biomédicas (CINBIO), University of Vigo, E36310 Vigo, Spain.

In utero growth restriction and being born small for gestational age are risk factors for respiratory morbidity. IUGR (in utero growth retardation) is associated to overall reduction in lung weight, surfactant content and activity, impaired maturation of the alveolar type II cells, and decreased alveolar formation. The renin-angiotensin system (RAS) may be a key target underlying pathophysiological lung alterations. Read More

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http://dx.doi.org/10.1155/2018/6920620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304858PMC
December 2018

Concentrations of Selected Adipokines, Interleukin-6, and Vitamin D in Patients with Papillary Thyroid Carcinoma in Respect to Thyroid Cancer Stages.

Int J Endocrinol 2018 3;2018:4921803. Epub 2018 Dec 3.

Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry, Medical University of Silesia, Zabrze, Poland.

The relationships between thyroid cancer and obesity are not fully understood. Adipokines, proinflammatory cytokines, and vitamin D may mediate these associations. In this study, we estimated serum concentrations of leptin, adiponectin, chemerin, interleukin-6 (IL-6), and vitamin D in patients with papillary thyroid cancer (PTC). Read More

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https://www.hindawi.com/journals/ije/2018/4921803/
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http://dx.doi.org/10.1155/2018/4921803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304902PMC
December 2018
8 Reads

Atherogenic Index in Type 2 Diabetes and Its Relationship with Chronic Microvascular Complications.

Int J Endocrinol 2018 29;2018:1765835. Epub 2018 Nov 29.

Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.

Objective: This study was designed to investigate risk factors related to atherogenic index of plasma (AIP), as well as the relationship between AIP and chronic microvascular complications in patients with type 2 diabetes (T2DM).

Methods: This study included 2523 patients with T2DM who had not been treated with lipid-lowering drugs and were admitted to the Department of Endocrinology at Zhongnan Hospital, Wuhan University, during the period from January 2015 to February 2018. Anthropometric indicators were measured after overnight fasting. Read More

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https://www.hindawi.com/journals/ije/2018/1765835/
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http://dx.doi.org/10.1155/2018/1765835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304911PMC
November 2018
7 Reads

High Expression of Somatostatin Receptors 2A, 3, and 5 in Corticotroph Pituitary Adenoma.

Int J Endocrinol 2018 9;2018:1763735. Epub 2018 Dec 9.

Center for CNS Tumors, Comprehensive Cancer Center Tuebingen-Stuttgart, University Hospital Tuebingen, Eberhard-Karls-University Tuebingen, Germany.

The development of somatostatin analogs for the treatment of pituitary Cushing's disease has been based on somatostatin receptor expression analyses of small cohorts of pituitary adenomas. Additionally, the classification of pituitary adenomas has recently changed. To enable progress with this treatment option, we assessed somatostatin receptors in a large cohort of corticotroph and other pituitary adenomas according to the new WHO classification of endocrine tumors. Read More

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http://dx.doi.org/10.1155/2018/1763735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304820PMC
December 2018
1 Read

The Value of Peripheral Enhancement Pattern for Diagnosing Thyroid Cancer Using Contrast-Enhanced Ultrasound.

Int J Endocrinol 2018 2;2018:1625958. Epub 2018 Dec 2.

Department of Ultrasound, Chinese People's Liberation Army General Hospital, China.

Background: Contrast-enhanced ultrasound (CEUS) scanning can detect differences between thyroid tumors and surrounding tissues. However, enhancement patterns within nodules are insufficient for the diagnosis of thyroid carcinomas. The peripheral enhancement patterns of nodules may provide useful diagnostic information. Read More

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https://www.hindawi.com/journals/ije/2018/1625958/
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http://dx.doi.org/10.1155/2018/1625958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304846PMC
December 2018
8 Reads
1.515 Impact Factor

The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review.

Int J Endocrinol 2018 14;2018:9128754. Epub 2018 Nov 14.

Faculty of Ceilândia, University of Brasília, Brasília, DF, Brazil.

Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Read More

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http://dx.doi.org/10.1155/2018/9128754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282135PMC
November 2018
2 Reads

C1q/TNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components.

Int J Endocrinol 2018 22;2018:7201473. Epub 2018 Nov 22.

Key Laboratory of Diagnostic Medicine (Ministry of Education) and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, 400016, China.

Objective: C1q/TNF-related protein5 (CTRP5) is a member of the C1q/tumor necrosis factor - (TNF--) related protein family and has been reported to be associated with the regulation of glucose and lipid metabolism. However, the clinical association between CTRP5 and metabolic syndrome (MetS) has not been reported. The aim of the current study is to investigate the association between CTRP5 and MetS by a cross-sectional study. Read More

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http://dx.doi.org/10.1155/2018/7201473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282127PMC
November 2018
1.515 Impact Factor

Inositols in Insulin Signaling and Glucose Metabolism.

Int J Endocrinol 2018 25;2018:1968450. Epub 2018 Nov 25.

Department of Experimental Medicine, Systems Biology Group Lab, Sapienza University of Rome, via A. Scarpa 16, 00161 Rome, Italy.

In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of inositol, inhibiting, among others, its intestinal absorption. Moreover, intracellular glucose is required for de novo biosynthesis of inositol through the inositol-3-phosphate synthase 1 pathway, while a few glucose-related metabolites, like sorbitol, reduce intracellular levels of inositol. Read More

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http://dx.doi.org/10.1155/2018/1968450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286734PMC
November 2018

Verification That Mouse Chromosome 14 Is Responsible for Susceptibility to Streptozotocin in NSY Mice.

Int J Endocrinol 2018 21;2018:7654979. Epub 2018 Nov 21.

Department of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, Osaka, Japan.

Introduction: Streptozotocin- (STZ-) induced diabetes is under polygenic control, and the genetic loci for STZ susceptibility are mapped to chromosome (Chr) 11 in Nagoya-Shibata-Yasuda (NSY) mice. In addition to Chr11, other genes on different chromosomes may contribute to STZ susceptibility in NSY mice. The aim of this study was to determine whether NSY-Chr14 contributes to STZ susceptibility and contains the STZ-susceptible region. Read More

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http://dx.doi.org/10.1155/2018/7654979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280298PMC
November 2018

Current Management of Polycystic Ovary Syndrome: From Bench to Bedside.

Int J Endocrinol 2018 14;2018:7234543. Epub 2018 Nov 14.

Department of Woman and Child Health, University of Padua, Padua, Italy.

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https://www.hindawi.com/journals/ije/2018/7234543/
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http://dx.doi.org/10.1155/2018/7234543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261402PMC
November 2018
3 Reads
1.515 Impact Factor

Relationship between Thyroid Function and Kidney Function in Patients with Type 2 Diabetes.

Int J Endocrinol 2018 14;2018:1871530. Epub 2018 Nov 14.

Department of endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Purpose: To determine if the TSH is related to estimated glomerular filtration rate (eGFR) in T2D patients without overt thyroid dysfunction.

Methods: A cohort study of 5936 T2D patients was assessed for thyroid and kidney functions, in whom 248 with subclinical hyperthyroidism and 362 with subclinical hypothyroidism. Serum creatinine and 24-hour urine albumin excretion (UAE) were collected. Read More

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https://www.hindawi.com/journals/ije/2018/1871530/
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http://dx.doi.org/10.1155/2018/1871530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261246PMC
November 2018
10 Reads
1.515 Impact Factor

Safety and Efficacy of Low-Level Laser Therapy in Autoimmune Thyroiditis: Long-Term Follow-Up Study.

Int J Endocrinol 2018 4;2018:8387530. Epub 2018 Nov 4.

Ultrasound Unit, Department of Radiology, University of Sao Paulo Medical School, Hospital das Clínicas, 05403-000 São Paulo, SP, Brazil.

Introduction: A randomized clinical trial (RCT) was performed to evaluate the efficacy of low-level laser therapy (LLLT) for hypothyroidism induced by chronic autoimmune thyroiditis (CAT).

Objective: The objective was to assess the safety and actions of LLLT 6 years after completion of the RCT.

Materials And Methods: Forty-three participants were invited to participate in this study 6 years after completion of the RCT. Read More

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https://www.hindawi.com/journals/ije/2018/8387530/
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http://dx.doi.org/10.1155/2018/8387530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247385PMC
November 2018
2 Reads

Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels.

Int J Endocrinol 2018 8;2018:3709534. Epub 2018 Nov 8.

Department of Endocrinology and Metabolism, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Background: The present study is undertaken to investigate the fibrinogen levels in type 2 diabetes mellitus (T2DM) and its relation to peripheral artery disease (PAD) based on a more accurate and applied noninvasive measurements of duplex ultrasonography.

Methods: We performed a cross-sectional study including 1096 T2DM patients (474 males and 622 females). The odds ratios (ORs) and 95% confidence intervals (CIs) were presented to show the association between PAD and fibrinogen in the subjects divided by fibrinogen levels quarterly. Read More

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http://dx.doi.org/10.1155/2018/3709534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250013PMC
November 2018

Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatment with Dexamethasone in Rats.

Int J Endocrinol 2018 8;2018:3257812. Epub 2018 Nov 8.

Department of Physical Education, Faculty of Sciences, São Paulo State University-UNESP, Bauru, SP, Brazil.

Objective: Fibrates are used as lipid-lowering drugs and are well tolerated as cotreatments when glucose metabolism disturbances are also present. Synthetic glucocorticoids (GCs) are diabetogenic drugs that cause dyslipidemia, dysglycemia, glucose intolerance, and insulin resistance when in excess. Thus, we aimed to describe the potential of bezafibrate in preventing or attenuating the adverse effects of GCs on glucose and lipid homeostasis. Read More

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http://dx.doi.org/10.1155/2018/3257812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250034PMC
November 2018

Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes.

Int J Endocrinol 2018 31;2018:6170154. Epub 2018 Oct 31.

Division of Endocrinology, Diabetes and Metabolism, State University of New York, Buffalo and Kaleida Health 462 Grider Street, Buffalo NY-14215, USA.

A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomized, placebo-controlled trial to evaluate the effect of one dose of intranasal insulin (40 IU of regular insulin) or saline on LH concentrations in 14 men (8 with type 2 diabetes and 6 healthy lean men). Read More

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http://dx.doi.org/10.1155/2018/6170154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234437PMC
October 2018
1 Read
1.515 Impact Factor

Effects of Estrogen and Estrogen Receptors on Transcriptomes of HepG2 Cells: A Preliminary Study Using RNA Sequencing.

Int J Endocrinol 2018 28;2018:5789127. Epub 2018 Oct 28.

Department of Biology, Miami University, 700 E. High St., Oxford, OH, USA.

Men have a much higher incidence of hepatocellular carcinoma (HCC), the predominant form of , than women, suggesting that estrogens play a protective role in liver cancer development and progression. To begin to understand the potential mechanisms of estrogens' inhibitory effects on HCC development, RNA sequencing was used to generate comprehensive global transcriptome profiles of the human HCC-derived HepG2 cell line following treatment of vehicle (control), estradiol (E2), estrogen receptor alpha- (ER-) specific agonist 1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole (PPT), or ER-specific agonist 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN) using a small set of cells. Gene ontology (GO) analysis identified increased expression of genes involved in the biological process (BP) of response to different stimuli and metabolic processes by E2 and ER agonists, which enhanced molecular function (MF) in various enzyme activities and chemical bindings. Read More

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http://dx.doi.org/10.1155/2018/5789127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230429PMC
October 2018
2 Reads

Fasting-Evoked En Route Hypoglycemia in Diabetes (FEEHD): An Overlooked Form of Hypoglycemia in Clinical Practice.

Int J Endocrinol 2018 24;2018:1528437. Epub 2018 Oct 24.

Michigan State University Extension-Flint, USA.

Objective: Many patients with diabetes opt to fast for lab tests, especially for lipid profiles, thus missing breakfast. In parallel, recent studies and international guidelines have indicated that routine fasting for lipid panels may not be necessary. Missing breakfast while fasting for lab tests may invoke hypoglycemia, if patients are not properly instructed about adjusting diabetes medications on the night before or on the day of the lab test. Read More

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https://www.hindawi.com/journals/ije/2018/1528437/
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http://dx.doi.org/10.1155/2018/1528437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220390PMC
October 2018
7 Reads

Corrigendum to "Expression of Intratumoral IGF-II Is Regulated by the Gene Imprinting Status in Triple Negative Breast Cancer from Vietnamese Patients".

Int J Endocrinol 2018 23;2018:8434297. Epub 2018 Oct 23.

Center for Health Disparities and Molecular Medicine, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.

[This corrects the article DOI: 10.1155/2015/401851.]. Read More

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http://dx.doi.org/10.1155/2018/8434297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218738PMC
October 2018
2 Reads

Is Atorvastatin Associated with New Onset Diabetes or Deterioration of Glycemic Control? Systematic Review Using Data from 1.9 Million Patients.

Int J Endocrinol 2018 22;2018:8380192. Epub 2018 Oct 22.

Society of Junior Doctors, Athens, Greece.

Background: Current evidence indicates that statins increase the risk of new onset diabetes mellitus (NOD) and also deteriorate the glycemic control in patients with known diabetes mellitus (DM) after high-dose statin therapy.

Aims: The aim of this review was to explore the effect of atorvastatin in causing NOD or deteriorating glycemic control in patients with DM.

Methods: Two independent reviewers conducted the literature search, through PubMed database searching for articles published in English until April 2015, and only primary studies were included. Read More

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https://www.hindawi.com/journals/ije/2018/8380192/
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http://dx.doi.org/10.1155/2018/8380192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217757PMC
October 2018
17 Reads

Characteristics and Outcomes of 79 Patients with an Insulinoma: A Nationwide Retrospective Study in Finland.

Int J Endocrinol 2018 23;2018:2059481. Epub 2018 Oct 23.

Faculty of Medicine and Life Sciences, University of Tampere, Finland.

Objective: Insulinomas are rare pancreatic tumours. Population-based data on their incidence, clinical picture, diagnosis, and treatment are almost nonexistent. The aim of this study was to clarify these aspects in a nationwide cohort of insulinoma patients diagnosed during three decades. Read More

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https://www.hindawi.com/journals/ije/2018/2059481/
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http://dx.doi.org/10.1155/2018/2059481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218736PMC
October 2018
8 Reads

Corrigendum to "Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction".

Int J Endocrinol 2018 23;2018:1239718. Epub 2018 Oct 23.

Centro de Endocrinología Experimental y Aplicada (CENEXA), UNLP-CONICET-FCM, 1900 La Plata, Argentina.

[This corrects the article DOI: 10.1155/2016/7838290.]. Read More

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http://dx.doi.org/10.1155/2018/1239718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218739PMC
October 2018
1 Read

Gender in Endocrine Diseases: Role of Sex Gonadal Hormones.

Int J Endocrinol 2018 21;2018:4847376. Epub 2018 Oct 21.

IRCCS Regina Elena National Cancer Institute, Endocrinology Unit, Rome, Italy.

Gender- and sex- related differences represent a new frontier towards patient-tailored medicine, taking into account that theoretically every medical specialty can be influenced by both of them. Sex hormones define the differences between males and females, and the different endocrine environment promoted by estrogens, progesterone, testosterone, and their precursors might influence both human physiology and pathophysiology. With the term Gender we refer, instead, to behaviors, roles, expectations, and activities carried out by the individual in society. Read More

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http://dx.doi.org/10.1155/2018/4847376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215564PMC
October 2018
1 Read

Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves' Orbitopathy.

Int J Endocrinol 2018 21;2018:1978590. Epub 2018 Oct 21.

Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.

Purpose: Intravenous methylprednisolone (IVMP) pulse therapy is the first-line treatment in active moderate-to-severe Graves' orbitopathy (GO) and dysthyroid optic neuropathy (DON). One of the adverse effects of this therapy is liver dysfunction that can be mild (ALT < 100 U/L), moderate (ALT: 100-300 U/L), and severe defined as acute liver injury (ALI) (ALT > 300 U/L). ALI can be irreversible and fatal. Read More

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http://dx.doi.org/10.1155/2018/1978590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215562PMC
October 2018
11 Reads

Palmitic Acid Downregulates Thyroglobulin (Tg), Sodium Iodide Symporter (NIS), and Thyroperoxidase (TPO) in Human Primary Thyrocytes: A Potential Mechanism by Which Lipotoxicity Affects Thyroid?

Int J Endocrinol 2018 17;2018:4215848. Epub 2018 Oct 17.

Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.

Our previous studies suggested that the thyroid might be a target organ affected by lipotoxicity, which might be partially related to the increasing prevalence of subclinical hypothyroidism. However, the underlying molecular mechanism is not yet clearly established. This study aimed to assess the effect of palmitic acid stimulation on thyrocyte function. Read More

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https://www.hindawi.com/journals/ije/2018/4215848/
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http://dx.doi.org/10.1155/2018/4215848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207890PMC
October 2018
10 Reads

Clinical, Genetics, and Bioinformatic Characterization of Mutations Affecting an Essential Region of in Patients with BMND18.

Int J Endocrinol 2018 14;2018:8953217. Epub 2018 Oct 14.

School of Biology & Basic Medical Sciences, Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, China.

Background: Bone mineral density quantitative trait locus 18 (BMND18, OMIM #300910) is a type of early-onset osteogenesis imperfecta (OI) caused by loss-of-function mutations in the PLS3 gene, which encodes plastin-3, a key protein in the formation of actin bundles throughout the cytoskeleton. Here, we report a patient with PLS3 mutation caused BMND18 and evaluated all the reported disease-causing mutations by bioinformatic analysis.

Methods: Targeted gene sequencing was performed to find the disease-causing mutation in our patient. Read More

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https://www.hindawi.com/journals/ije/2018/8953217/
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http://dx.doi.org/10.1155/2018/8953217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204236PMC
October 2018
2 Reads