2,854 results match your criteria International Journal of Developmental Neuroscience [Journal]


Rehabilitation-induced brain changes detected through magnetic resonance imaging in children with neurodevelopmental disorders: A systematic review.

Int J Dev Neurosci 2018 Dec 11. Epub 2018 Dec 11.

Department of Occupational Science & Occupational Therapy, University of British Columbia, Vancouver, Canada; BC Children's Hospital Research Institute, Vancouver, Canada; Department of Pediatrics, University of British Columbia, Vancouver, Canada; Sunny Hill Health Centre for Children, Vancouver, Canada. Electronic address:

Aim: The aim of this study was to systematically review evidence about rehabilitation-induced neuroplasticity measured by magnetic resonance imaging (MRI) in children with neurodevelopmental disorders.

Method: The following databases were searched: MEDLINE, EMBASE, CINAHL, and PsycINFO. Two independent reviewers screened articles according to inclusion criteria: (1) peer-review study published in a scientific journal; (2) studies that evaluated a rehabilitation-based intervention; (3) participants aged less than 19 years with a neurodevelopmental disorder; (4) studies that used at least one MRI modality as an outcome measure. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.12.001DOI Listing
December 2018
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Behavioural and epigenetic effects of paternal exposure to cannabinoids during adolescence on offspring vulnerability to stress.

Int J Dev Neurosci 2018 Nov 23;72:48-54. Epub 2018 Nov 23.

Institute of Academic Anaesthesia, Division of Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. Electronic address:

Chronic cannabinoid exposure during adolescence in male rats induces chronic cognitive and emotional impairments. However, the impact of this form of exposure on offspring vulnerability to stress is unknown. The aim of this study was to evaluate the behavioural and epigenetic effects of stress in the offspring of male rats whose fathers were exposed to cannabinoids during adolescence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748183020
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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.007DOI Listing
November 2018
3 Reads

Age-related changes in Ki-67 and DCX expression in the BALB/ c mouse (Mus Musculus) brain.

Int J Dev Neurosci 2018 Nov 22;72:36-47. Epub 2018 Nov 22.

School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, 2190, South Africa. Electronic address:

Several studies have identified age as one of the strongest regulators of neurogenesis in the mammalian brain. However, previous age-related studies focused mainly on changes in neurogenesis during different stages of adulthood and did not describe changes in neurogenesis through the different life history stages of the animal. The aim of this study was therefore to determine time course changes in neurogenesis in the male BALB/c mouse brain at postnatal ages 1 week to 12 weeks, spanning juvenile, sub adult and adult life history stages. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.005DOI Listing
November 2018

Impact of neuroimmune activation induced by alcohol or drug abuse on adolescent brain development.

Int J Dev Neurosci 2018 Nov 20. Epub 2018 Nov 20.

Department of Molecular and Cellular Pathology of Alcohol, Príncipe Felipe Research Center, Valencia, Spain; Department of Physiology, School of Medicine and Dentistry, University of Valencia, Valencia, Spain.

Evidence obtained in recent decades has demonstrated that the brain still matures in adolescence. Changes in neural connectivity occur in different regions, including cortical and subcortical structures, which undergo modifications in white and gray matter densities. These alterations concomitantly occur in some neurotransmitter systems and hormone secretion, which markedly influence the refinement of certain brain areas and neural circuits. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.006DOI Listing
November 2018
5 Reads

Nerve cells developmental processes and the dynamic role of cytokine signaling.

Int J Dev Neurosci 2018 Nov 19. Epub 2018 Nov 19.

Department of Neuroscience, University of Padova, via Gabelli 65, I-35121, Padova, Italy.

The stunning diversity of neurons and glial cells makes possible the higher functions of the central nervous system (CNS), allowing the organism to sense, interpret and respond appropriately to the external environment. This cellular diversity derives from a single primary progenitor cell type initiating lineage leading to the formation of both differentiated neurons and glial cells. The processes governing the differentiation of the progenitor pool of cells into mature nerve cells will be here briefly reviewed. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.003DOI Listing
November 2018
3 Reads

Placental Macrophages: A Window Into Fetal Microglial Function in Maternal Obesity.

Int J Dev Neurosci 2018 Nov 20. Epub 2018 Nov 20.

Pediatrics and Program in Neuroscience, Harvard Medical School; Lurie Center for Autism, MassGeneral Hospital for Children. Electronic address:

Fetal placental macrophages and microglia (resident brain macrophages) have a common origin in the fetal yolk sac. Yolk-sac-derived macrophages comprise the permanent pool of brain microglia throughout an individual's lifetime. Inappropriate fetal microglial priming may therefore have lifelong neurodevelopmental consequences, but direct evaluation of microglial function in a living fetus or neonate is impossible. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.004DOI Listing
November 2018
4 Reads

Fundamentals of fetal toxicity relevant to sevoflurane exposures during pregnancy.

Int J Dev Neurosci 2018 Nov 15;72:31-35. Epub 2018 Nov 15.

Department of Anesthesiology and Critical Care Medicine, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Over the last three decades, advances in medical and surgical techniques have proven life saving and life-improving for young children. Consequently, early and repeated exposure to general anesthetics in childhood has increased. However, accumulating evidence suggests that general anesthetics may be neurotoxic in children. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.001DOI Listing
November 2018
2.580 Impact Factor

Maternal folic acid deficiency stimulates neural cell apoptosis via miR-34a associated with Bcl-2 in the rat foetal brain.

Int J Dev Neurosci 2018 Nov 14;72:6-12. Epub 2018 Nov 14.

Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, 300070, China. Electronic address:

Embryonic development is a critical period wherein brain neurons are generated and organized. Maternal dietary folate, a cofactor in one-carbon metabolism, modulates neurogenesis and apoptosis in foetal brain neurons. We hypothesized that aberrant neuronal apoptosis may affect the development of the central nervous system during maternal folic acid deficiency, with evident effects because maternal folic acid deficiency modulates the microRNA-34a associated with Bcl-2 pathway during embryonic development. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.002DOI Listing
November 2018
7 Reads

A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: Does maternal inflammation play a role?

Int J Dev Neurosci 2018 Nov 2. Epub 2018 Nov 2.

Department of Anatomy and Neuroscience and Cork Neuroscience Centre, Western Gateway Building, University College Cork, Cork, Ireland. Electronic address:

Pre-eclampsia is a leading cause of maternal death and maternal and perinatal morbidity. Whilst the clinical manifestations of pre-eclampsia often occur in late pregnancy, the molecular events leading into the onset of this disease are thought to originate in early pregnancy and result in insufficient placentation. Although the causative molecular basis of pre-eclampsia remains poorly understood, maternal inflammation is recognised as a core clinical feature. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.10.004DOI Listing
November 2018
2 Reads

Shank3B mutant mice display pitch discrimination enhancements and learning deficits.

Int J Dev Neurosci 2018 Oct 29;72:13-21. Epub 2018 Oct 29.

University of Connecticut, Psychology-Behavioral Neuroscience, 406 Babbidge Road, Unit 1020 Storrs, 06269, CT, USA.

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by a core set of atypical behaviors in social-communicative and repetitive-motor domains. Individual profiles are widely heterogeneous and include language skills ranging from nonverbal to hyperlexic. The causal mechanisms underlying ASD remain poorly understood but appear to include a complex combination of polygenic and environmental risk factors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748183021
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http://dx.doi.org/10.1016/j.ijdevneu.2018.10.003DOI Listing
October 2018
1 Read

Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia.

Int J Dev Neurosci 2018 Oct 29;72:1-5. Epub 2018 Oct 29.

Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, Sacramento, CA, USA; Department of Pediatrics, University of California Davis School of Medicine, Sacramento, CA, USA. Electronic address:

Premutation carriers of the FMR1 gene (CGG repeats between 55 and 200) usually have normal intellectual abilities but approximately 20% are diagnosed with developmental problems or autism spectrum disorder. Additionally, close to 50% have psychiatric problems such as anxiety, ADHD and/or depression. The spectrum of fragile X disorders also includes Fragile-X-associated primary ovarian insufficiency (FXPOI) in female carriers and Fragile-X-associated tremor/ataxia syndrome (FXTAS) in older male and female carriers. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.10.002DOI Listing
October 2018

Gestational folic acid supplementation does not affects the maternal behavior and the early development of rats submitted to neonatal hypoxia-ischemia but the high supplementation impairs the dam's memory and the Na, K - ATPase activity in the pup's hippocampus.

Int J Dev Neurosci 2018 Dec 11;71:181-192. Epub 2018 Oct 11.

Programa de Pós-Graduação em Neurociências, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, sala 107, 90050- 170, Porto Alegre, RS, Brazil; Departamento de Ciências Morfológicas, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, 90050- 170, Porto Alegre, RS, Brazil. Electronic address:

Folic acid (FA) is a B-complex vitamin important to the development of the fetus, being supplemented during pregnancy. Our recent findings showed that gestation supplementation (normal and excess doses) prevented the cognitive deficits and BDNF imbalance in adult rats that were submitted to neonatal hypoxia-ischemia (HI). To better understand this protective effect, the present study aimed to evaluate whether FA supplementation could be related to (1) maternal behavior, memory and Na, K - ATPase activity in the hippocampus of the dams; (2) on somatic growth, early neurobehavioral development and Na, K - ATPase activity in the hippocampus of the offspring; and (3) the effects of this supplementation in pups submitted to neonatal HI. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.10.001DOI Listing
December 2018

Dual functions of microglia in the formation and refinement of neural circuits during development.

Int J Dev Neurosci 2018 Oct 4. Epub 2018 Oct 4.

Department of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata 951-8585, Japan. Electronic address:

Microglia colonize the central nervous system (CNS) parenchyma during embryogenesis and contribute to various developmental processes leading to the formation of refined neural circuits. In this review, we focus on the bidirectional function of microglia during normal CNS development and discuss recent perspectives on the functions of microglia in neural circuit formation. Microglia participate in neurogenesis, migration, axonal growth, and synapse formation and remodeling, all of which are fundamental for the establishment of neural networks, by secreting a variety of molecules toward neurons and phagocytosing both live and dying neurons or their debris. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.009DOI Listing
October 2018
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Protective effects of quercetin against brain injury in a rat model of lipopolysaccharide-induced fetal brain injury.

Authors:
Qian Wang Cong Liu

Int J Dev Neurosci 2018 Dec 30;71:175-180. Epub 2018 Sep 30.

Department of Traditional Chinese Medicine, Daqing Oilfields General Hospital, No. 9 Zhongkang Road, Daqing, 163000, Heilongjiang, China.

Maternal exposure to lipopolysaccharide (LPS), a bacterial endotoxin produced during infection, leads to disruption in fetal brain development and causes newborn brain injury. Quercetin (QR) is a multipotent flavonoid that functions as an antioxidant and protects against inflammation and neurodegeneration. In this study, we explored the potential functions of QR in alleviating maternal LPS exposure induced fetal brain damage. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.008DOI Listing
December 2018
6 Reads
2.580 Impact Factor

The biochemical characterization of a missense mutation m.8914C>T in ATP6 gene associated with mitochondrial encephalomyopathy.

Int J Dev Neurosci 2018 Dec 28;71:172-174. Epub 2018 Sep 28.

Pediatric Department of the Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Shandong, 266000, PR China. Electronic address:

Mutations in ATP6 gene are frequent causes of mitochondrial encephalomyopathies. ATP6 gene encodes one subunit of complexⅤ. The present study described a missense mutation in ATP6 gene in a 8-year-old Chinese boy with mitochondrial encephalomyopathy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748183012
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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.007DOI Listing
December 2018
7 Reads

A novel C-terminal truncated mutation in hCDKL5 protein causing a severe West syndrome: Comparison with previous truncated mutations and genotype/phenotype correlation.

Int J Dev Neurosci 2018 Sep 17;72:22-30. Epub 2018 Sep 17.

Laboratory of Molecular and Functional Genetics, Faculty of Science of Sfax, University of Sfax, Tunisia. Electronic address:

Introduction: West Syndrome is a severe epileptic encephalopathy characterized by epileptic spasms, hypsarrhythmia, and regression of psychomotor acquisitions beginning in the first year of life. ARX and CDKL5 genes were identified as linked to the most frequent genetic causes of West Syndrome.

Methods: The present study reports the clinical, molecular and bioinformatic investigation of the patient with severe West syndrome. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.006DOI Listing
September 2018

Effect of maternal antioxidant supplementation and/or exercise practice during pregnancy on postnatal overnutrition induced by litter size reduction: Brain redox homeostasis at weaning.

Int J Dev Neurosci 2018 Dec 16;71:146-155. Epub 2018 Sep 16.

Programa de Pós-graduação em Ciências Biológicas: Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Programa de Pós-graduação em Ciências Biológicas: Fisiologia, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address:

Prenatal and early postnatal environments can permanently influence health throughout life. Early overnutrition increases the risk to develop chronic diseases. Conversely, the intake of flavonoids and exercise practice during pregnancy seem to promote long-term benefits to offspring. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.003DOI Listing
December 2018

Maternal diet of polyunsaturated fatty acid influence the physical and neurobehaviour of rat offspring.

Int J Dev Neurosci 2018 Dec 14;71:156-162. Epub 2018 Sep 14.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China; Institute of Hospital Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China. Electronic address:

Background: Polyunsaturated fatty acids (PUFAs) are normal components of growth and development and its derivatives especially n-3 PUFAs have an influence on the development and maturation of nervous system. The purpose of our present study was to investigate the effect of maternal n-3 PUFAs dietary on physical maturation and the neurobiological development of the rat offspring.

Methods: According to the content of n-3 PUFAs in their diets, female dams were randomly divided into three treatment groups (n = 6-7): deficiency, control and supplementation. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.005DOI Listing
December 2018

Single nucleotide polymorphism array analysis uncovers a large, novel duplication in Xq13.1 in a floppy infant syndrome patient.

Int J Dev Neurosci 2018 Sep 12. Epub 2018 Sep 12.

Department of Operating room, Dezhou municipal hospital, Dezhou, China.

Objective: To identify candidate genes for the clinical diagnosis of floppy infant syndrome (FIS) using single nucleotide polymorphism (SNP) array in a specific FIS family.

Methods: SNP array analysis of the whole chromosome copy number was performed in the proband (III). Multiple polymerase chain reaction (PCR) combined with denaturing high-performance liquid chromatography (DHPLC) was used to validate the array data. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.004DOI Listing
September 2018

A review of interventions against fetal alcohol spectrum disorder targeting oxidative stress.

Int J Dev Neurosci 2018 Dec 8;71:140-145. Epub 2018 Sep 8.

Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Introduction: Fetal alcohol spectrum disorder is caused by maternal ethanol exposure; it causes physical, behavioral, cognitive, and neural impairments (Murawski et al., 2015). Mechanisms of FASD causing damage are not yet fully elucidated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748183009
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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.001DOI Listing
December 2018
6 Reads

The neuropathological investigation of the brain in a monkey model of autism spectrum disorder with ABCA13 deletion.

Int J Dev Neurosci 2018 Dec 7;71:130-139. Epub 2018 Sep 7.

Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

The precise biological etiology of autism spectrum disorder (ASD) remains unknown. In this study, we investigated the neuropathology of a monkey model of autism Human ABCA13 is the largest ABC transporter protein, with a length of 5058 amino acids and a predicted molecular weight of >450 kDa. However, the function of this protein remains to be elucidated. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.002DOI Listing
December 2018

Swimming exercise before and during pregnancy: Promising preventive approach to impact offspring´s health.

Int J Dev Neurosci 2018 Dec 30;71:83-93. Epub 2018 Aug 30.

Programa de Pós-Graduação em Ciências Biológicas-Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Programa de Pós-graduação em Fisiologia, Instituto de Ciências Básicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address:

Several environmental factors affect child development, such as the intrauterine environment during the embryonic and fetal development and early postnatal environment provided by maternal behavior. Although mechanistic effects of maternal exercise on offspring health improvement are not yet completely understood, the number of reports published demonstrating the positive influence of maternal exercise have increase. Herein, we addressed issues related to early postnatal environment provided by maternal behavior and early developmental physical landmarks, sensorimotor reflexes, and motor movements ontogeny. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.009DOI Listing
December 2018
8 Reads

A systematic review of structural MRI biomarkers in autism spectrum disorder: A machine learning perspective.

Int J Dev Neurosci 2018 Dec 30;71:68-82. Epub 2018 Aug 30.

CSIRO Health and Biosecurity, The Australian e-Health Research Centre, Brisbane, Australia.

Autism Spectrum Disorder (ASD) affects approximately 1% of the population and leads to impairments in social interaction, communication and restricted, repetitive behaviours. Establishing robust neuroimaging biomarkers of ASD using structural magnetic resonance imaging (MRI) is an important step for diagnosing and tailoring treatment, particularly early in life when interventions can have the greatest effect. However currently, there is mixed findings on the structural brain changes associated with autism. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.010DOI Listing
December 2018

Vitamin D partially reverses the increase in p-NF-κB/p65 immunocontent and interleukin-6 levels, but not in acetylcholinesterase activity in hippocampus of adult female ovariectomized rats.

Int J Dev Neurosci 2018 Dec 30;71:122-129. Epub 2018 Aug 30.

Laboratório de Neuroproteção e Doenças Neurometabólicas, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, CEP 90035-003, Porto Alegre, RS, Brazil. Electronic address:

The aim of this study was to verify the effects of ovariectomy (OVX) and/or vitamin D supplementation (VIT D) on inflammatory and cholinergic parameters in hippocampus, as well as on serum estradiol and VIT D levels of rats. Ninety-day-old female Wistar rats were randomly divided into four groups: SHAM, OVX, VIT D or OVX + VIT D. Thirty days after OVX, VIT D (500 IU/kg/day) was supplemented by gavage, for 30 days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748173037
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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.008DOI Listing
December 2018
1 Read

NGF, TrkA-P and neuroprotection after a hypoxic event in the developing central nervous system.

Int J Dev Neurosci 2018 Dec 27;71:111-121. Epub 2018 Aug 27.

Instituto de Biología Celular y Neurociencias (IBCN) Dr. Eduardo de Robertis, Facultad de Medicina, CONICET, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina. Electronic address:

A decrease in the concentration of oxygen in the blood and tissues (hypoxia) produces important, sometimes irreversible, damages in the central nervous system (CNS) both during development and also postnatally. The present work aims at analyzing the expression of nerve growth factor (NGF) and p75 and the activation of TrkA in response to an acute normobaric hypoxic event and to evaluate the possible protective role of exogenous NGF. The developing chick optic tectum (OT), a recognized model of corticogenesis, was used as experimental system by means of in vivo and in vitro studies. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.007DOI Listing
December 2018
8 Reads

Sex differences in the peripheral and central immune responses following lipopolysaccharide treatment in pubertal and adult CD-1 mice.

Int J Dev Neurosci 2018 Dec 27;71:94-104. Epub 2018 Aug 27.

School of Psychology, Faculty of Social Sciences, University of Ottawa, Canada. Electronic address:

Puberty is a critical developmental period that is characterized by significant brain development. Exposure to stress during this time can alter brain functioning setting the stage for long-lasting behavioural outcomes. The objective of this study was to investigate age and sex differences in the peripheral and central immune responses, along with sickness behaviour, following immune stress. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.012DOI Listing
December 2018
2 Reads

Background cortisol versus social anxiety as correlates of HPA-axis recovery from stress in boys with Autism Spectrum Disorder.

Int J Dev Neurosci 2018 Dec 27;71:52-60. Epub 2018 Aug 27.

Brain-Behaviour Research Group, University of New England, Armidale, NSW, 2350, Australia.

Children with Autism Spectrum Disorder (ASD) show dysregulation of the expected Hypothalamus-Pituitary-Adrenal (HPA) axis and elevated cortisol responses to stress and response patterns, but little has been reported regarding their recovery from stress in terms of cortisol concentrations. This response was investigated in a sample of 32 young males with ASD aged between 9 and 18 years (M = 14.3 yr, SD = 2. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.004DOI Listing
December 2018
6 Reads

Peroxisome proliferator-activated receptor alpha accelerates neuronal differentiation and this might involve the mitogen-activated protein kinase pathway.

Int J Dev Neurosci 2018 Dec 26;71:46-51. Epub 2018 Aug 26.

Department of Biochemistry, College of Medicine, China Medical University, Taichung, Taiwan, ROC. Electronic address:

Activation of peroxisome proliferator-activated receptor alpha (PPARα) has been reported to modulate cell proliferation, migration, and differentiation in astrocytes. In this study, we used a retinoic acid (RA)-induced differentiation model of NTERA-2/clone D1 (NT2) cells to explore the functional significance of PPARα in neuronal differentiation. We found that activating PPARα by Wy14643 accelerated neuronal differentiation via regulating the expression of neuronal markers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748183014
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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.006DOI Listing
December 2018
9 Reads

Effects of perinatal undernutrition on social transmission of food preference in adult male Wistar rats.

Int J Dev Neurosci 2018 Dec 24;71:105-110. Epub 2018 Aug 24.

Department of Developmental Neurobiology and Neurophysiology, Institute of Neurobiology, Universidad Nacional Autónoma de México, Mexico. Electronic address:

Nutrition plays a fundamental role in learning and memory, and early experimental undernutrition interferes with brain memory processes. Social transmission of food preference (STFP) is a natural olfactory paired-associate learning test that has not been used to assess the effects of early undernutrition on memory consolidation. Male Wistar rats were randomly divided into two groups: control and early undernourished. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.005DOI Listing
December 2018
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The reduction in sexual behavior induced by neonatal immune stress is not related to androgen levels in male rats.

Int J Dev Neurosci 2018 Dec 18;71:163-171. Epub 2018 Aug 18.

Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.

Purpose: It is known that various types of stress in early life increase the incidence of diabetes, myocardial infarctions, and psychiatric disorders in adulthood. We examined the mechanism by which neonatal immune stress reduces sexual behavior in adult male rats.

Methods: Male rats were randomly divided into 3 groups: the control (n = 17), postnatal day 10 lipopolysaccharide (PND10LPS) (n = 31), and PND25LPS (n = 16) groups, which received intraperitoneal injections of LPS (100 μg/kg) or saline (injection volume: ≤0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748183011
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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.003DOI Listing
December 2018
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Regional volumetric abnormalities in pediatric autism revealed by structural magnetic resonance imaging.

Int J Dev Neurosci 2018 Dec 12;71:34-45. Epub 2018 Aug 12.

Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, 401 Park Dr., Boston, MA, 02215, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA, 02129, USA.

Autism is a group of complex neurodevelopmental disorders characterized by impaired social interaction, restricted and repetitive behavior. We performed a large-scale retrospective analysis of 1,996 structural magnetic resonance imaging (MRI) examinations of the brain from 1,769 autistic and neurologically typically developing patients (aged 0-32 years), and extracted regional volumetric measurements distributed across 463 brain regions of each patient. The youngest autistic patients (<2. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.001DOI Listing
December 2018

Maternal dairy fat diet does not influence neurotrophin levels and cognitive performance in the rat offspring at adult age.

Int J Dev Neurosci 2018 Dec 12;71:18-29. Epub 2018 Aug 12.

Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth Deemed University, Pune 411043, India. Electronic address:

Cognitive development may be influenced by maternal nutrition especially fats. Indian population is vegetarian and main source of fat is dairy. This study investigates the effect of dairy fat consumption during pregnancy in an animal model on fatty acids, brain neurotrophins (brain derived neurotrophic factor: BDNF; and nerve growth factor: NGF) and cognitive performance in adult offspring. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.002DOI Listing
December 2018
10 Reads

Physical activity as an option to reduce adverse effect of EMF exposure during pregnancy.

Int J Dev Neurosci 2018 Dec 1;71:10-17. Epub 2018 Aug 1.

Department of Radiology and Surgery, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

The popularity of using wireless fidelity over the last decades increased apprehensions about impact of high frequency electromagnetic fields (EMF) on health. Most of previous studies mentioned adverse effect of EMF on cognitive processes, but so far, no study has provided a way to control adverse effects of EMF exposure. The purpose of this study was to examine the effect of Wi-Fi EMF and physical activity on spatial learning and motor function in pregnant rat's offspring. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.009DOI Listing
December 2018

Sex-specific effects of CB1 receptor antagonism and stress in adolescence on anxiety, corticosterone concentrations, and contextual fear in adulthood in rats.

Int J Dev Neurosci 2018 Oct 29;69:119-131. Epub 2018 Jul 29.

Department of Biological Sciences, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Ontario, L2S 3A1, Canada; Department of Psychology, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Ontario, L2S 3A1, Canada; Center for Neuroscience, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Ontario, L2S 3A1, Canada. Electronic address:

There is a paucity of research regarding the role of endogenous cannabinoid signalling in adolescence on brain and behaviour development. We previously demonstrated effects of repeated CB1 receptor antagonism in adolescence on socioemotional behaviours and neural protein expression 24-48 h after the last drug administration in female rats, with no effect in males. Here we investigate whether greater effects would be manifested after a lengthier delay. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.011DOI Listing
October 2018
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Interactions between eye movements and posture in children with neurodevelopmental disorders.

Int J Dev Neurosci 2018 Dec 26;71:61-67. Epub 2018 Jul 26.

Child and Adolescent Psychiatry Department, Robert Debré Hospital, Paris, France; Paris Diderot University, Paris 7, France; High Functioning Autism Expert Centre, Fondamental Foundation, Paris, France.

In everyday life, our activities frequently involve the simultaneous performance of two or more tasks. Sharing attention between two concurrent tasks may result in a decrease in performance specifically among children with neurodevelopmental disorders. The objective of the study was to determine whether the influence of postural conditions (sitting condition, single task; standing condition, dual task) on eye movement performances on three visual tasks with high attentional load (visually-guided saccade task, memory-guided saccade task and fixation task) was different in children with neurodevelopmental disorders (attention deficit and hyperactive disorder, dyslexia, and high functioning autism spectrum disorder) when compared to typically developing children. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.010DOI Listing
December 2018
12 Reads

Postnatal development of inhibitory synaptic transmission in the anterior piriform cortex.

Int J Dev Neurosci 2018 Dec 25;71:1-9. Epub 2018 Jul 25.

Neurophysiology and Neurochemistry of Neuronal Excitability and Synaptic Plasticity Laboratory, Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address:

The morphological and functional development of inhibitory circuit in the anterior piriform cortex (aPC) during the first three postnatal weeks may be crucial for the development of odor preference learning in infant rodents. As first step toward testing this hypothesis, we examined the normal development of GABAergic synaptic transmission in the aPC of rat pups during the postnatal days (P) 5-8 and 14-17. Whole cell patch-clamp recordings of layer 2/3 (L2/3) aPC pyramidal cells revealed a significant increase in spontaneous (sIPSC) and miniature (mIPSC) inhibitory postsynaptic current frequencies and a decrease in mIPSC rise and decay-time constant at P14-P17. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.008DOI Listing
December 2018
4 Reads

Hypoxia ischemia update.

Int J Dev Neurosci 2018 Nov 24;70:1-2. Epub 2018 Jul 24.

University of Texas Medical Branch, Galveston, Texas, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.007DOI Listing
November 2018

Notch signaling in human iPS-derived neuronal progenitor lines from Focal Cortical Dysplasia patients.

Int J Dev Neurosci 2018 Oct 23;69:112-118. Epub 2018 Jul 23.

Brain Institute of Rio Grande do Sul (BraIns), Brazil.

Focal Cortical Dysplasia (FCD), a common type of Malformations of cortical development, may result from an early disturbance in the migration and final arrangement of the cortical architecture of immature neurons. FCD type II is now known to be due to a post-zygotic somatic mutation that involves the mTOR and AKT pathways. The aim of the present study was to investigate the possible differences in neurogenesis and neurodifferentiation of iPSCs (induced pluripotent stem cells) from fibroblasts of individuals affected by FCD type II (2) and normal individuals (2). Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.006DOI Listing
October 2018

Ginkgolide B ameliorates NLRP3 inflammasome activation after hypoxic-ischemic brain injury in the neonatal male rat.

Int J Dev Neurosci 2018 Oct 17;69:106-111. Epub 2018 Jul 17.

Department of Pediatrics, The Second People's Hospital of Taizhou Affiliated to Yangzhou University, Taizhou, Jiangsu, China. Electronic address:

Introduction: Perinatal hypoxic-ischemic (HI) insult is an important cause of brain injury in neonates. The development of novel treatment strategies for neonates with HI brain injury is urgently needed. Ginkgolide B (GB) is a main component of Ginkgo biloba extracts with a long history of use in traditional Chinese medicine. Read More

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October 2018
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Prenatal undernutrition attenuates fasting-induced reproductive dysfunction in pre-pubertal male rats.

Int J Dev Neurosci 2018 Dec 17;71:30-33. Epub 2018 Jul 17.

Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan.

Prenatal undernutrition affects various physiological functions, such as metabolic and reproductive functions, after birth, and such changes are associated with the pathogeneses of certain diseases. It has been hypothesized that these changes are predictive adaptive responses that help individuals to endure similar conditions in the postnatal period. Thus, we evaluated the effects of prenatal undernutrition on the responses of the body weight (BW) regulation system and reproductive functions to fasting in the pre-pubertal period in male rats. Read More

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December 2018
2 Reads

Disappearance of cerebrovascular laminin immunoreactivity as related to the maturation of astroglia in rat brain.

Int J Dev Neurosci 2018 Oct 20;69:97-105. Epub 2018 Jul 20.

Department of Anatomy, Histology, Embryology, Semmelweis University, Budapest, Hungary; Department of Physiology, Anatomy, Genetics, Univ. of Oxford, UK. Electronic address:

The present paper provides novel findings on the temporo-spatial correlation of perivascular laminin immunoreactivity with the early postnatal astrocyte development. The cerebrovascular laminin immunoreactivity gradually disappears during development. The fusion of the glial and vascular basal laminae during development makes the laminin epitopes inaccessible for antibody molecules (Krum et al. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.003DOI Listing
October 2018

Fisetin impedes developmental methylmercury neurotoxicity via downregulating apoptotic signalling pathway and upregulating Rho GTPase signalling pathway in hippocampus of F generation rats.

Int J Dev Neurosci 2018 Oct 20;69:88-96. Epub 2018 Jul 20.

Dr.ALMPG IBMS, University of Madras, Taramani Campus, Chennai, 600113, Tamil Nadu, India. Electronic address:

Methyl mercury is a teratogenic and neurodevelopmental toxicant in the environment. MeHg affects several biological pathways critical for brain development. The present study validated the effect of Fisetin on developmental MeHg exposure induced alterations in mitochondrial apoptotic pathway and Rho GTPase mRNA expressions in hippocampus of F generation rats. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.002DOI Listing
October 2018

Neurobehavioral effects of long-term maternal fructose intake in rat offspring.

Int J Dev Neurosci 2018 Oct 9;69:68-79. Epub 2018 Jul 9.

Ege University School of Medicine, Department of Physiology, Izmir, Turkey. Electronic address:

Background: Previous studies have indicated an association between maternal metabolic conditions and general developmental disturbances of the offspring.

Objective: We aimed to investigate the influence of long-term maternal fructose intake during gestation and lactation on neurobehavioral development of rat offspring.

Methods: Twelve female Sprague Dawley rats were received either 30% fructose enriched water (n = 6) or regular tap water (control, n = 6) for 12 weeks. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.001DOI Listing
October 2018
11 Reads

Prenatal undernutrition decreases the anorectic response to septic doses of lipopolysaccharides in adulthood in male rats.

Int J Dev Neurosci 2018 Oct 30;69:39-43. Epub 2018 Jun 30.

Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, 770-8503, Japan.

Prenatal undernutrition affects some physiological functions after birth, and such changes are associated with the pathogenesis of various diseases. Recently, we have reported that prenatally undernourished male rats exhibited stronger febrile and anorectic responses to immune stress induced by moderate-dose lipopolysaccharide (LPS) treatment in adulthood. In the present study, we evaluated the effects of prenatal undernutrition on stress responses to the administration of a septic dose (3 mg/kg) of LPS in later life, mainly focusing on changes in hypothalamic proinflammatory cytokine expression. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.06.010DOI Listing
October 2018
3 Reads

Frankincense upregulates the hippocampal calcium/calmodulin kinase II-α during development of the rat brain and improves memory performance.

Int J Dev Neurosci 2018 Oct 30;69:44-48. Epub 2018 Jun 30.

Division of Animal Sciences, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran.

Background: Frankincense is an oleo gum resin derived from trees of genus Boswellia. It has favorable effects on memory formation. However, the probable underlying molecular mechanisms have not been assessed. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.06.011DOI Listing
October 2018
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Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido-inflammatory stress in rat model of autism.

Int J Dev Neurosci 2018 Oct 30;69:80-87. Epub 2018 Jun 30.

Faculty of Herbs, Amol University of Special Modern Technologies, Amol, Iran.

Prenatal exposure to valproic acid (VPA) induces behavioral disorders and enhancement of oxido-inflammatory stress in Autism Spectrum Disorders (ASDs). The aim of this study was to investigate the comparative effects of hesperetin (Hst) and nano-hesperetin on social behavior deficits and oxido-inflammatory indexes in prenatally valproic acid-exposed rat offspring. Pregnant Wistar rats on embryonic day 0 (E0) were segregated into six groups; Group-1 served as vehicle, received distillated water orally (PO) from E1 until the end of lactation and saline intraperitoneally (i. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.06.009DOI Listing
October 2018

Adult rat morphine exposure changes morphine preference, anxiety, and the brain expression of dopamine receptors in male offspring.

Int J Dev Neurosci 2018 Oct 30;69:49-59. Epub 2018 Jun 30.

Genetics Laboratory, Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Institute for Studies in Theoretical Physics and Mathematics, School of Cognitive Sciences, Tehran, Iran; Institute for Cognitive Science Studies, Tehran, Iran.

Addiction to drugs, including opioids is the result of an interplay between environmental and genetic factors. It has been shown that the progeny of addict people is at higher risk for drug addiction. However, the mechanisms of such trans-generational effects of drugs are not so clear. Read More

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October 2018
7 Reads

Hypoxia and myelination deficits in the developing brain.

Int J Dev Neurosci 2018 Nov 28;70:3-11. Epub 2018 Jun 28.

Department of Anatomy, Yong Loo Lin School of Medicine, MD10, 4 Medical drive, National University of Singapore, 117597, Singapore. Electronic address:

Myelination is a complex and orderly process during brain development that is essential for normal motor, cognitive and sensory functions. Cellular and molecular interactions between myelin-forming oligodendrocytes and axons are required for normal myelination in the developing brain. Oligodendrocyte progenitor cells (OPCs) proliferate and differentiate into mature myelin-forming oligodendrocytes. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.06.012DOI Listing
November 2018
13 Reads
2.580 Impact Factor

Immature sleep pattern in newborn rats when dams encountered sleep restriction during pregnancy.

Int J Dev Neurosci 2018 Oct 28;69:60-67. Epub 2018 Jun 28.

Division of Sleep Research, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, 695012, Kerala, India. Electronic address:

There is a growing realization that proper sleep during pregnancy is essential for the health of the mother and the offspring. However, there are no reports on the effects of maternal sleep restriction on the sleep-wake profiles of newborns. So, this study was conducted to evaluate the effects of sleep restriction during the third term of pregnancy on the sleep-wake profiles of neonates born to them. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.06.007DOI Listing
October 2018

Bone morphogenetic protein 4 expression in the developing lumbosacral spinal cord of rat embryos with anorectal malformations.

Int J Dev Neurosci 2018 Oct 28;69:32-38. Epub 2018 Jun 28.

Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address:

Although there are improvements in treatment of anorectal malformations (ARMs), patients can still develop fecal incontinence, constipation, and soiling with loss in quality of life. Recent evidence suggests that malformations in the lumbosacral spinal cord are one of the factors that affect postoperative anorectal function. However, the underlying mechanism that produces these malformations has yet to be elucidated. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.06.006DOI Listing
October 2018
2 Reads