2,870 results match your criteria International Journal of Developmental Neuroscience [Journal]


Role of DAPK1 in neuronal cell death, survival and diseases in the nervous system.

Int J Dev Neurosci 2019 Feb 11;74:11-17. Epub 2019 Feb 11.

Department of Biology, College of Sciences, United Arab Emirates University, Al Ain, P.O. Box 17551, United Arab Emirates. Electronic address:

DAPK (death-associated protein kinase) is a calcium/calmodulin (Ca/CaM) regulated serine/threonine kinase. Structurally, it assumes a multi-domain structure and participates in various apoptotic systems which imply that it may interact with a wide range of intracellular components to exert its action. DAPK plays vital roles in pro-apoptotic, apoptotic and autophagic pathways. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2019.02.003DOI Listing
February 2019
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Time course and expression pattern of the neuronal markers in the developing human spinal cord.

Int J Dev Neurosci 2019 Feb 10;74:1-10. Epub 2019 Feb 10.

School of Medicine, University of Split, Department of Anatomy, Histology and Embryology, Laboratory for Early Human Development, Šoltanska 2, 21000, Split, Croatia. Electronic address:

The aim of this study was to examine the spatio-temporal appearance of different neuronal cell subtypes by analyzing expression patterns of several neuronal markers (calretinin, neurofilament 200 (NF200), vanilloid receptor 1(VR1) and calcitonin gene-related peptide (CGRP)) of the embryonic human spinal cord (SC). Developing human SCs from 11 human conceptuses beetwen 5-10 developmental weeks (DW) were examined by light and electron microscopy and immunofluorescence. Light and electron microscopy revealed different embryonic stages of recognizable structure of the SC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748183033
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http://dx.doi.org/10.1016/j.ijdevneu.2019.02.001DOI Listing
February 2019
1 Read

Repeated neonatal needle-prick stimulation increases inflammatory mechanical hypersensitivity in adult rats.

Int J Dev Neurosci 2019 Feb 8. Epub 2019 Feb 8.

Institute of Motricity Sciences, Federal University of Alfenas, UNIFAL-MG, Alfenas, MG, Brazil. Electronic address:

Background And Aims: Newborn infants are vulnerable to procedural stress and pain exposure on the first weeks of life that represents a critical period for the development of nociceptive, sensory, emotional, and social functions. We evaluated the nociceptive behavior of adult male and female rats that were submitted to nociceptive experience in the neonatal period and the maternal behavior in the postnatal period.

Methods: The animals were submitted to repetitive needle pricking from the second to the fifteenth postnatal day (PND 2-15). Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2019.02.004DOI Listing
February 2019
1 Read

The development of monoaminergic neurotransmitter systems in childhood and adolescence.

Authors:
Martina Pitzer

Int J Dev Neurosci 2019 Feb 6. Epub 2019 Feb 6.

Department of Child and Adolescent Psychiatry, Vitos Klinik Rheinhöhe, Kloster-Eberbach-Str. 4, 65346 Eltville, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijdevneu.2019.02.002DOI Listing
February 2019
2 Reads

Polarized microglia do not influence oligodendrocyte lineage cells via astrocytes.

Int J Dev Neurosci 2019 Feb 1. Epub 2019 Feb 1.

Hannover Medical School, Department of. Neurology and Department of Clinical Neuroimmunology and Neurochemistry, Hannover, Germany; Center of Systems Neuroscience, Hannover, Germany. Electronic address:

Microglia can adopt different activation patterns, ranging from a pro-inflammatory M1- to an anti-inflammatory M2-like phenotype in which they play crucial roles in various neuroinflammatory diseases. M2-like microglia are described to drive remyelination, whereas detrimental effects have been attributed to M1-like microglia. How polarized microglia might act on oligodendrocyte lineage cells indirectly by influencing astrocytes has not been studied in detail. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2019.01.006DOI Listing
February 2019

Involvement of AMP-activated protein kinase in neuroinflammation and neurodegeneration in the adult and developing brain.

Int J Dev Neurosci 2019 Jan 29. Epub 2019 Jan 29.

Departments of Medicine and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, Annenberg 19-201, New York, NY, 10029, USA.

Microglial activation followed by neuroinflammation is a defense mechanism of the brain to eliminate harmful endogenous and exogenous materials including pathogens and damaged tissues, while excessive or chronic neuroinflammation may cause or exacerbate neurodegeneration observed in brain injuries and neurodegenerative diseases. Depending on conditions/environments during activation, microglia acquire distinct phenotypes, such as pro-inflammatory, anti-inflammatory, and disease-associated phenotypes, and show their ability to phagocytose various objects and produce pro-and anti-inflammatory mediators. Prevention of excessive inflammation by regulating the microglia's pro/anti-inflammatory balance is important for alleviating progression of brain injuries and diseases. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2019.01.007DOI Listing
January 2019
4 Reads

Surface- and voxel-based brain morphologic study in Rett and Rett-like syndrome with MECP2 mutation.

Int J Dev Neurosci 2019 Apr 25;73:83-88. Epub 2019 Jan 25.

Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.

Rett syndrome (RTT) is a rare congenital disorder which in most cases (95%) is caused by methyl-CpG binding protein 2 (MECP2) mutations. RTT is characterized by regression in global development, epilepsy, autistic features, acquired microcephaly, habitual hand clapping, loss of purposeful hand skills, and autonomic dysfunctions. Although the literature has demonstrated decreased volumes of the cerebrum, cerebellum, and the caudate nucleus in RTT patients, surface-based brain morphology including cortical thickness and cortical gyrification analyses are lacking in RTT. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377336PMC

Exosomes populate the cerebrospinal fluid of preterm infants with post-haemorrhagic hydrocephalus.

Int J Dev Neurosci 2019 Apr 9;73:59-65. Epub 2019 Jan 9.

Regenerative Medicine Laboratory, Bristol Medical School, University of Bristol, UK.

Background: Preterm infants are at risk of germinal matrix haemorrhage-intraventricular haemorrhage (GMH-IVH) which leads to post-haemorrhagic hydrocephalus (PHH) in 30% of infants; this is associated with moderate-severe neurodevelopmental impairment and confers significant risk of cerebral palsy. There are however no predictive indicators of the severity or long-term outcome after GMH-IVH. In recent years, endosome-derived extracellular vesicles (EVs) or exosomes have been isolated from biofluids and shown to mediate intercellular communication via selective enrichment in proteins and micro-RNAs. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2019.01.004DOI Listing
April 2019
2 Reads

The placenta as a window to the brain: A review on the role of placental markers in prenatal programming of neurodevelopment.

Int J Dev Neurosci 2019 Apr 8;73:41-49. Epub 2019 Jan 8.

Optics and Imaging Centre, School of Laboratory Medicine and Medical Sciences, Nelson Mandela Medical School, University of KwaZulu-Natal, Durban, South Africa.

Background: During development, the placenta can be said to be the most important organ, however, the most poorly researched. There is currently a broader understanding of how specific insults during development affect the fetal brain, and also the importance of placental signaling in neurodevelopmental programming. Epigenetic responses to maternal and fetal signals are an obvious candidate for transforming early life inputs into long-term programmatic outcomes. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2019.01.003DOI Listing

Developmental regulation and lateralization of GABA receptors in the rat hippocampus.

Int J Dev Neurosci 2019 Jan 7. Epub 2019 Jan 7.

Department of Anatomy and cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Medical Genetic Research Center (MGRC), Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

GABA is the chief inhibitory neurotransmitter in the adult brain. However, in the developing brain it acts as an excitatory transmitter causing depolarization. Thereby, activates calcium-dependent processes that are crucial for brain development. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2019.01.002DOI Listing
January 2019
1 Read
2.580 Impact Factor

Spoken word processing in Rett syndrome: Evidence from event-related potentials.

Int J Dev Neurosci 2019 Apr 7;73:26-31. Epub 2019 Jan 7.

Vanderbilt Kennedy Center for Research on Human Development, Nashville, TN 37203, United States; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, United States. Electronic address:

This study examined the feasibility of using auditory event-related potentials to evaluate spoken word processing during passive listening in girls with Rett syndrome (n = 11) and typical peers (n = 33), age 4-12 years. The typical group demonstrated the expected pattern of more negative amplitudes within 200-500 ms in response to words than nonwords at left temporal sites. In participants with Rett syndrome, word-nonword differentiation was observed at the right temporal sites. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377340PMC

Cortical expression of AMPA receptors during postnatal development in a genetic model of absence epilepsy.

Int J Dev Neurosci 2019 Apr 26;73:19-25. Epub 2018 Dec 26.

Department of Anatomy, Brain Health Research Centre, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand. Electronic address:

Childhood absence epilepsy has been associated with poor academic performance, behavioural difficulties, as well as increased risk of physical injury in some affected children. The frequent episodes of 'absence' arise from corticothalamocortical network dysfunction, with multifactorial mechanisms potentially involved in genetically different patients. Aberrations in glutamatergic neurotransmission has been implicated in some seizure models, and we have recently reported that reduced cortical AMPA receptor (AMPAR) expression (predominantly GluA4- containing AMPARs) in parvalbumin-containing (PV) inhibitory interneurons, could underlie seizure generation in the stargazer mutant mouse. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.12.006DOI Listing

Treatment with 1-benzylpiperazine (BZP) during adolescence of male and female hooded rats exposed to environmental enrichment: Subsequent behavioral outcomes.

Int J Dev Neurosci 2019 Apr 24;73:32-40. Epub 2018 Dec 24.

Department of Psychology, University of Canterbury, Christchurch 8140, New Zealand. Electronic address:

From 30 days after birth until the completion of the study, male and female rats were caged in same-sexed twos or threes either with (enriched cages, EC) or without several objects for them to explore (standard cages, SC). From 41 to 50 days of age (late adolescence), they received a daily intraperitoneal injection of saline, or 10 or 20 mg/kg of the monoaminergic agonist drug of abuse, 1-benzylpiperazine (BZP). Ten days later (PND60+), their behavior was observed over several days in an open field, an elevated plus maze, a light-dark box and (to assess short-term memory) a Y maze in which one of the arms had been changed in brightness between two trials. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.12.005DOI Listing

Methylphenidate alters Akt-mTOR signaling in rat pheochromocytoma cells.

Int J Dev Neurosci 2019 Apr 19;73:10-18. Epub 2018 Dec 19.

Laboratory of Neuroprotection and Metabolic Diseases, Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Programa de Pós‑Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

The exponential increase in methylphenidate (MPH) prescriptions in recent years has worried researchers about its misuse among individuals who do not meet the full diagnostic criteria for attention-deficit/hyperactivity disorder (ADHD) such as young children and students in search of cognitive improvement or for recreational reasons. The action of MPH is based mainly on inhibition of dopamine transporter, but the complete cellular effects are still unknown. Based upon prior studies, we attempted to determine whether the treatment with MPH (1μM) influences protein kinase B-mammalian target of rapamycin complex 1 signaling pathways (Akt-mTOR), including translation repressor protein (4E-BP1) and mitogen activated protein kinase (S6K), in rat pheochromocytoma cells (PC12), a well characterized cellular model, in a long or short term. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.12.004DOI Listing
April 2019
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The developing optic tectum: An asymmetrically organized system and the need for a redefinition of the notion of sensitive period.

Int J Dev Neurosci 2019 Apr 17;73:1-9. Epub 2018 Dec 17.

Grupo Interdisciplinario de Biología Teórica, Instituto de Neurociencia Cognitiva y Traslacional (INCyT), Universidad Favaloro-INECO-CONICET, Buenos Aires, Argentina; Instituto de Biología Celular y Neurociencias (IBCN) Dr. Eduardo de Robertis, Facultad de Medicina, CONICET, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.

The present article summarizes the main events involved in the isthmic organizer and optic tectum determination and analyses how optic tectum patterning is translated, by the organized operation of several specific cell behaviors, into the terminally differentiated optic tectum. The paper proposes that this assembling of temporally/spatially organized cell behaviors could be incorporated into a wider notion of patterning and that, given the asymmetric organization of the developing optic tectum, the notion of "sensitive period" does not capture the whole complexity of midbrain development and the pathogenesis of congenital disorders. The cell behaviors involved in the optic tectum development are organized in time and space by the isthmic organizer. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.12.003DOI Listing

Behavioral, cognitive and histological changes following neonatal anoxia: Male and female rats' differences at adolescent age.

Int J Dev Neurosci 2019 Apr 15;73:50-58. Epub 2018 Dec 15.

Neurosciences Laboratory, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Av. Professor Lineu Prestes, 2415, 05508-900, São Paulo, SP, Brazil. Electronic address:

Neonatal anoxia induces long-term brain injury that may underlie neurobehavioral deficits at adolescence. Neonatal anoxia, induced by exposure of 30-hour old pups to 100% nitrogen, represents a non-invasive and global stimulus, which simulates clinical conditions of human pre-term babies (around 6 gestational months). Previous studies showed that neonatal anoxia induced impairments of spatial memory and altered anxiety-like behaviors in male rats tested at adult age. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.12.002DOI Listing

Rehabilitation-induced brain changes detected through magnetic resonance imaging in children with neurodevelopmental disorders: A systematic review.

Int J Dev Neurosci 2019 Apr 11;73:66-82. Epub 2018 Dec 11.

Department of Occupational Science & Occupational Therapy, University of British Columbia, Vancouver, Canada; BC Children's Hospital Research Institute, Vancouver, Canada; Department of Pediatrics, University of British Columbia, Vancouver, Canada; Sunny Hill Health Centre for Children, Vancouver, Canada. Electronic address:

Aim: The aim of this study was to systematically review evidence about rehabilitation-induced neuroplasticity measured by magnetic resonance imaging (MRI) in children with neurodevelopmental disorders.

Method: The following databases were searched: MEDLINE, EMBASE, CINAHL, and PsycINFO. Two independent reviewers screened articles according to inclusion criteria: (1) peer-review study published in a scientific journal; (2) studies that evaluated a rehabilitation-based intervention; (3) participants aged less than 19 years with a neurodevelopmental disorder; and (4) studies that used at least one MRI modality as an outcome measure. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.12.001DOI Listing
April 2019
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Behavioural and epigenetic effects of paternal exposure to cannabinoids during adolescence on offspring vulnerability to stress.

Int J Dev Neurosci 2019 Feb 23;72:48-54. Epub 2018 Nov 23.

Institute of Academic Anaesthesia, Division of Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. Electronic address:

Chronic cannabinoid exposure during adolescence in male rats induces chronic cognitive and emotional impairments. However, the impact of this form of exposure on offspring vulnerability to stress is unknown. The aim of this study was to evaluate the behavioural and epigenetic effects of stress in the offspring of male rats whose fathers were exposed to cannabinoids during adolescence. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.007DOI Listing
February 2019
8 Reads

Age-related changes in Ki-67 and DCX expression in the BALB/ c mouse (Mus Musculus) brain.

Int J Dev Neurosci 2019 Feb 22;72:36-47. Epub 2018 Nov 22.

School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, 2190, South Africa. Electronic address:

Several studies have identified age as one of the strongest regulators of neurogenesis in the mammalian brain. However, previous age-related studies focused mainly on changes in neurogenesis during different stages of adulthood and did not describe changes in neurogenesis through the different life history stages of the animal. The aim of this study was therefore to determine time course changes in neurogenesis in the male BALB/c mouse brain at postnatal ages 1 week to 12 weeks, spanning juvenile, sub adult and adult life history stages. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.005DOI Listing
February 2019

Impact of neuroimmune activation induced by alcohol or drug abuse on adolescent brain development.

Int J Dev Neurosci 2018 Nov 20. Epub 2018 Nov 20.

Department of Molecular and Cellular Pathology of Alcohol, Príncipe Felipe Research Center, Valencia, Spain; Department of Physiology, School of Medicine and Dentistry, University of Valencia, Valencia, Spain.

Evidence obtained in recent decades has demonstrated that the brain still matures in adolescence. Changes in neural connectivity occur in different regions, including cortical and subcortical structures, which undergo modifications in white and gray matter densities. These alterations concomitantly occur in some neurotransmitter systems and hormone secretion, which markedly influence the refinement of certain brain areas and neural circuits. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.006DOI Listing
November 2018
9 Reads

Nerve cells developmental processes and the dynamic role of cytokine signaling.

Int J Dev Neurosci 2018 Nov 19. Epub 2018 Nov 19.

Department of Neuroscience, University of Padova, via Gabelli 65, I-35121, Padova, Italy.

The stunning diversity of neurons and glial cells makes possible the higher functions of the central nervous system (CNS), allowing the organism to sense, interpret and respond appropriately to the external environment. This cellular diversity derives from a single primary progenitor cell type initiating lineage leading to the formation of both differentiated neurons and glial cells. The processes governing the differentiation of the progenitor pool of cells into mature nerve cells will be here briefly reviewed. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.003DOI Listing
November 2018
8 Reads

Placental Macrophages: A Window Into Fetal Microglial Function in Maternal Obesity.

Int J Dev Neurosci 2018 Nov 20. Epub 2018 Nov 20.

Pediatrics and Program in Neuroscience, Harvard Medical School; Lurie Center for Autism, MassGeneral Hospital for Children. Electronic address:

Fetal placental macrophages and microglia (resident brain macrophages) have a common origin in the fetal yolk sac. Yolk-sac-derived macrophages comprise the permanent pool of brain microglia throughout an individual's lifetime. Inappropriate fetal microglial priming may therefore have lifelong neurodevelopmental consequences, but direct evaluation of microglial function in a living fetus or neonate is impossible. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.004DOI Listing
November 2018
10 Reads

Fundamentals of fetal toxicity relevant to sevoflurane exposures during pregnancy.

Int J Dev Neurosci 2019 Feb 15;72:31-35. Epub 2018 Nov 15.

Department of Anesthesiology and Critical Care Medicine, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Over the last three decades, advances in medical and surgical techniques have proven life saving and life-improving for young children. Consequently, early and repeated exposure to general anesthetics in childhood has increased. However, accumulating evidence suggests that general anesthetics may be neurotoxic in children. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.001DOI Listing
February 2019
2.580 Impact Factor

Maternal folic acid deficiency stimulates neural cell apoptosis via miR-34a associated with Bcl-2 in the rat foetal brain.

Int J Dev Neurosci 2019 Feb 14;72:6-12. Epub 2018 Nov 14.

Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, 300070, China. Electronic address:

Embryonic development is a critical period wherein brain neurons are generated and organized. Maternal dietary folate, a cofactor in one-carbon metabolism, modulates neurogenesis and apoptosis in foetal brain neurons. We hypothesized that aberrant neuronal apoptosis may affect the development of the central nervous system during maternal folic acid deficiency, with evident effects because maternal folic acid deficiency modulates the microRNA-34a associated with Bcl-2 pathway during embryonic development. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.002DOI Listing
February 2019
16 Reads

A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: Does maternal inflammation play a role?

Int J Dev Neurosci 2018 Nov 2. Epub 2018 Nov 2.

Department of Anatomy and Neuroscience and Cork Neuroscience Centre, Western Gateway Building, University College Cork, Cork, Ireland. Electronic address:

Pre-eclampsia is a leading cause of maternal death and maternal and perinatal morbidity. Whilst the clinical manifestations of pre-eclampsia often occur in late pregnancy, the molecular events leading into the onset of this disease are thought to originate in early pregnancy and result in insufficient placentation. Although the causative molecular basis of pre-eclampsia remains poorly understood, maternal inflammation is recognised as a core clinical feature. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.10.004DOI Listing
November 2018
3 Reads

Shank3B mutant mice display pitch discrimination enhancements and learning deficits.

Int J Dev Neurosci 2019 Feb 29;72:13-21. Epub 2018 Oct 29.

University of Connecticut, Psychology-Behavioral Neuroscience, 406 Babbidge Road, Unit 1020 Storrs, 06269, CT, USA.

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by a core set of atypical behaviors in social-communicative and repetitive-motor domains. Individual profiles are widely heterogeneous and include language skills ranging from nonverbal to hyperlexic. The causal mechanisms underlying ASD remain poorly understood but appear to include a complex combination of polygenic and environmental risk factors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748183021
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http://dx.doi.org/10.1016/j.ijdevneu.2018.10.003DOI Listing
February 2019
1 Read

Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia.

Int J Dev Neurosci 2019 Feb 29;72:1-5. Epub 2018 Oct 29.

Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, Sacramento, CA, USA; Department of Pediatrics, University of California Davis School of Medicine, Sacramento, CA, USA. Electronic address:

Premutation carriers of the FMR1 gene (CGG repeats between 55 and 200) usually have normal intellectual abilities but approximately 20% are diagnosed with developmental problems or autism spectrum disorder. Additionally, close to 50% have psychiatric problems such as anxiety, ADHD and/or depression. The spectrum of fragile X disorders also includes Fragile-X-associated primary ovarian insufficiency (FXPOI) in female carriers and Fragile-X-associated tremor/ataxia syndrome (FXTAS) in older male and female carriers. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354926PMC
February 2019
2 Reads

Gestational folic acid supplementation does not affects the maternal behavior and the early development of rats submitted to neonatal hypoxia-ischemia but the high supplementation impairs the dam's memory and the Na, K - ATPase activity in the pup's hippocampus.

Int J Dev Neurosci 2018 Dec 11;71:181-192. Epub 2018 Oct 11.

Programa de Pós-Graduação em Neurociências, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, sala 107, 90050- 170, Porto Alegre, RS, Brazil; Departamento de Ciências Morfológicas, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, 90050- 170, Porto Alegre, RS, Brazil. Electronic address:

Folic acid (FA) is a B-complex vitamin important to the development of the fetus, being supplemented during pregnancy. Our recent findings showed that gestation supplementation (normal and excess doses) prevented the cognitive deficits and BDNF imbalance in adult rats that were submitted to neonatal hypoxia-ischemia (HI). To better understand this protective effect, the present study aimed to evaluate whether FA supplementation could be related to (1) maternal behavior, memory and Na, K - ATPase activity in the hippocampus of the dams; (2) on somatic growth, early neurobehavioral development and Na, K - ATPase activity in the hippocampus of the offspring; and (3) the effects of this supplementation in pups submitted to neonatal HI. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.10.001DOI Listing
December 2018
1 Read

Dual functions of microglia in the formation and refinement of neural circuits during development.

Int J Dev Neurosci 2018 Oct 4. Epub 2018 Oct 4.

Department of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata 951-8585, Japan. Electronic address:

Microglia colonize the central nervous system (CNS) parenchyma during embryogenesis and contribute to various developmental processes leading to the formation of refined neural circuits. In this review, we focus on the bidirectional function of microglia during normal CNS development and discuss recent perspectives on the functions of microglia in neural circuit formation. Microglia participate in neurogenesis, migration, axonal growth, and synapse formation and remodeling, all of which are fundamental for the establishment of neural networks, by secreting a variety of molecules toward neurons and phagocytosing both live and dying neurons or their debris. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.009DOI Listing
October 2018
2 Reads

Protective effects of quercetin against brain injury in a rat model of lipopolysaccharide-induced fetal brain injury.

Authors:
Qian Wang Cong Liu

Int J Dev Neurosci 2018 Dec 30;71:175-180. Epub 2018 Sep 30.

Department of Traditional Chinese Medicine, Daqing Oilfields General Hospital, No. 9 Zhongkang Road, Daqing, 163000, Heilongjiang, China.

Maternal exposure to lipopolysaccharide (LPS), a bacterial endotoxin produced during infection, leads to disruption in fetal brain development and causes newborn brain injury. Quercetin (QR) is a multipotent flavonoid that functions as an antioxidant and protects against inflammation and neurodegeneration. In this study, we explored the potential functions of QR in alleviating maternal LPS exposure induced fetal brain damage. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.008DOI Listing
December 2018
10 Reads
2.580 Impact Factor

The biochemical characterization of a missense mutation m.8914C>T in ATP6 gene associated with mitochondrial encephalomyopathy.

Int J Dev Neurosci 2018 Dec 28;71:172-174. Epub 2018 Sep 28.

Pediatric Department of the Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Shandong, 266000, PR China. Electronic address:

Mutations in ATP6 gene are frequent causes of mitochondrial encephalomyopathies. ATP6 gene encodes one subunit of complexⅤ. The present study described a missense mutation in ATP6 gene in a 8-year-old Chinese boy with mitochondrial encephalomyopathy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748183012
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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.007DOI Listing
December 2018
11 Reads

A novel C-terminal truncated mutation in hCDKL5 protein causing a severe West syndrome: Comparison with previous truncated mutations and genotype/phenotype correlation.

Int J Dev Neurosci 2019 Feb 17;72:22-30. Epub 2018 Sep 17.

Laboratory of Molecular and Functional Genetics, Faculty of Science of Sfax, University of Sfax, Tunisia. Electronic address:

Introduction: West Syndrome is a severe epileptic encephalopathy characterized by epileptic spasms, hypsarrhythmia, and regression of psychomotor acquisitions beginning in the first year of life. ARX and CDKL5 genes were identified as linked to the most frequent genetic causes of West Syndrome.

Methods: The present study reports the clinical, molecular and bioinformatic investigation of the patient with severe West syndrome. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.006DOI Listing
February 2019

Effect of maternal antioxidant supplementation and/or exercise practice during pregnancy on postnatal overnutrition induced by litter size reduction: Brain redox homeostasis at weaning.

Int J Dev Neurosci 2018 Dec 16;71:146-155. Epub 2018 Sep 16.

Programa de Pós-graduação em Ciências Biológicas: Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Programa de Pós-graduação em Ciências Biológicas: Fisiologia, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address:

Prenatal and early postnatal environments can permanently influence health throughout life. Early overnutrition increases the risk to develop chronic diseases. Conversely, the intake of flavonoids and exercise practice during pregnancy seem to promote long-term benefits to offspring. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.003DOI Listing
December 2018
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Maternal diet of polyunsaturated fatty acid influence the physical and neurobehaviour of rat offspring.

Int J Dev Neurosci 2018 Dec 14;71:156-162. Epub 2018 Sep 14.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China; Institute of Hospital Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China. Electronic address:

Background: Polyunsaturated fatty acids (PUFAs) are normal components of growth and development and its derivatives especially n-3 PUFAs have an influence on the development and maturation of nervous system. The purpose of our present study was to investigate the effect of maternal n-3 PUFAs dietary on physical maturation and the neurobiological development of the rat offspring.

Methods: According to the content of n-3 PUFAs in their diets, female dams were randomly divided into three treatment groups (n = 6-7): deficiency, control and supplementation. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.005DOI Listing
December 2018
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Single nucleotide polymorphism array analysis uncovers a large, novel duplication in Xq13.1 in a floppy infant syndrome patient.

Int J Dev Neurosci 2018 Sep 12. Epub 2018 Sep 12.

Department of Operating room, Dezhou municipal hospital, Dezhou, China.

Objective: To identify candidate genes for the clinical diagnosis of floppy infant syndrome (FIS) using single nucleotide polymorphism (SNP) array in a specific FIS family.

Methods: SNP array analysis of the whole chromosome copy number was performed in the proband (III). Multiple polymerase chain reaction (PCR) combined with denaturing high-performance liquid chromatography (DHPLC) was used to validate the array data. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.004DOI Listing
September 2018
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A review of interventions against fetal alcohol spectrum disorder targeting oxidative stress.

Int J Dev Neurosci 2018 Dec 8;71:140-145. Epub 2018 Sep 8.

Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Introduction: Fetal alcohol spectrum disorder is caused by maternal ethanol exposure; it causes physical, behavioral, cognitive, and neural impairments (Murawski et al., 2015). Mechanisms of FASD causing damage are not yet fully elucidated. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.001DOI Listing
December 2018
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The neuropathological investigation of the brain in a monkey model of autism spectrum disorder with ABCA13 deletion.

Int J Dev Neurosci 2018 Dec 7;71:130-139. Epub 2018 Sep 7.

Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

The precise biological etiology of autism spectrum disorder (ASD) remains unknown. In this study, we investigated the neuropathology of a monkey model of autism Human ABCA13 is the largest ABC transporter protein, with a length of 5058 amino acids and a predicted molecular weight of >450 kDa. However, the function of this protein remains to be elucidated. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.09.002DOI Listing
December 2018
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Swimming exercise before and during pregnancy: Promising preventive approach to impact offspring´s health.

Int J Dev Neurosci 2018 Dec 30;71:83-93. Epub 2018 Aug 30.

Programa de Pós-Graduação em Ciências Biológicas-Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Programa de Pós-graduação em Fisiologia, Instituto de Ciências Básicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address:

Several environmental factors affect child development, such as the intrauterine environment during the embryonic and fetal development and early postnatal environment provided by maternal behavior. Although mechanistic effects of maternal exercise on offspring health improvement are not yet completely understood, the number of reports published demonstrating the positive influence of maternal exercise have increase. Herein, we addressed issues related to early postnatal environment provided by maternal behavior and early developmental physical landmarks, sensorimotor reflexes, and motor movements ontogeny. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.009DOI Listing
December 2018
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A systematic review of structural MRI biomarkers in autism spectrum disorder: A machine learning perspective.

Int J Dev Neurosci 2018 Dec 30;71:68-82. Epub 2018 Aug 30.

CSIRO Health and Biosecurity, The Australian e-Health Research Centre, Brisbane, Australia.

Autism Spectrum Disorder (ASD) affects approximately 1% of the population and leads to impairments in social interaction, communication and restricted, repetitive behaviours. Establishing robust neuroimaging biomarkers of ASD using structural magnetic resonance imaging (MRI) is an important step for diagnosing and tailoring treatment, particularly early in life when interventions can have the greatest effect. However currently, there is mixed findings on the structural brain changes associated with autism. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.010DOI Listing
December 2018

Vitamin D partially reverses the increase in p-NF-κB/p65 immunocontent and interleukin-6 levels, but not in acetylcholinesterase activity in hippocampus of adult female ovariectomized rats.

Int J Dev Neurosci 2018 Dec 30;71:122-129. Epub 2018 Aug 30.

Laboratório de Neuroproteção e Doenças Neurometabólicas, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, CEP 90035-003, Porto Alegre, RS, Brazil. Electronic address:

The aim of this study was to verify the effects of ovariectomy (OVX) and/or vitamin D supplementation (VIT D) on inflammatory and cholinergic parameters in hippocampus, as well as on serum estradiol and VIT D levels of rats. Ninety-day-old female Wistar rats were randomly divided into four groups: SHAM, OVX, VIT D or OVX + VIT D. Thirty days after OVX, VIT D (500 IU/kg/day) was supplemented by gavage, for 30 days. Read More

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December 2018
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NGF, TrkA-P and neuroprotection after a hypoxic event in the developing central nervous system.

Int J Dev Neurosci 2018 Dec 27;71:111-121. Epub 2018 Aug 27.

Instituto de Biología Celular y Neurociencias (IBCN) Dr. Eduardo de Robertis, Facultad de Medicina, CONICET, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina. Electronic address:

A decrease in the concentration of oxygen in the blood and tissues (hypoxia) produces important, sometimes irreversible, damages in the central nervous system (CNS) both during development and also postnatally. The present work aims at analyzing the expression of nerve growth factor (NGF) and p75 and the activation of TrkA in response to an acute normobaric hypoxic event and to evaluate the possible protective role of exogenous NGF. The developing chick optic tectum (OT), a recognized model of corticogenesis, was used as experimental system by means of in vivo and in vitro studies. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.007DOI Listing
December 2018
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Sex differences in the peripheral and central immune responses following lipopolysaccharide treatment in pubertal and adult CD-1 mice.

Int J Dev Neurosci 2018 Dec 27;71:94-104. Epub 2018 Aug 27.

School of Psychology, Faculty of Social Sciences, University of Ottawa, Canada. Electronic address:

Puberty is a critical developmental period that is characterized by significant brain development. Exposure to stress during this time can alter brain functioning setting the stage for long-lasting behavioural outcomes. The objective of this study was to investigate age and sex differences in the peripheral and central immune responses, along with sickness behaviour, following immune stress. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.012DOI Listing
December 2018
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Background cortisol versus social anxiety as correlates of HPA-axis recovery from stress in boys with Autism Spectrum Disorder.

Int J Dev Neurosci 2018 Dec 27;71:52-60. Epub 2018 Aug 27.

Brain-Behaviour Research Group, University of New England, Armidale, NSW, 2350, Australia.

Children with Autism Spectrum Disorder (ASD) show dysregulation of the expected Hypothalamus-Pituitary-Adrenal (HPA) axis and elevated cortisol responses to stress and response patterns, but little has been reported regarding their recovery from stress in terms of cortisol concentrations. This response was investigated in a sample of 32 young males with ASD aged between 9 and 18 years (M = 14.3 yr, SD = 2. Read More

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December 2018
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Peroxisome proliferator-activated receptor alpha accelerates neuronal differentiation and this might involve the mitogen-activated protein kinase pathway.

Int J Dev Neurosci 2018 Dec 26;71:46-51. Epub 2018 Aug 26.

Department of Biochemistry, College of Medicine, China Medical University, Taichung, Taiwan, ROC. Electronic address:

Activation of peroxisome proliferator-activated receptor alpha (PPARα) has been reported to modulate cell proliferation, migration, and differentiation in astrocytes. In this study, we used a retinoic acid (RA)-induced differentiation model of NTERA-2/clone D1 (NT2) cells to explore the functional significance of PPARα in neuronal differentiation. We found that activating PPARα by Wy14643 accelerated neuronal differentiation via regulating the expression of neuronal markers. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.006DOI Listing
December 2018
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Effects of perinatal undernutrition on social transmission of food preference in adult male Wistar rats.

Int J Dev Neurosci 2018 Dec 24;71:105-110. Epub 2018 Aug 24.

Department of Developmental Neurobiology and Neurophysiology, Institute of Neurobiology, Universidad Nacional Autónoma de México, Mexico. Electronic address:

Nutrition plays a fundamental role in learning and memory, and early experimental undernutrition interferes with brain memory processes. Social transmission of food preference (STFP) is a natural olfactory paired-associate learning test that has not been used to assess the effects of early undernutrition on memory consolidation. Male Wistar rats were randomly divided into two groups: control and early undernourished. Read More

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December 2018
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The reduction in sexual behavior induced by neonatal immune stress is not related to androgen levels in male rats.

Int J Dev Neurosci 2018 Dec 18;71:163-171. Epub 2018 Aug 18.

Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.

Purpose: It is known that various types of stress in early life increase the incidence of diabetes, myocardial infarctions, and psychiatric disorders in adulthood. We examined the mechanism by which neonatal immune stress reduces sexual behavior in adult male rats.

Methods: Male rats were randomly divided into 3 groups: the control (n = 17), postnatal day 10 lipopolysaccharide (PND10LPS) (n = 31), and PND25LPS (n = 16) groups, which received intraperitoneal injections of LPS (100 μg/kg) or saline (injection volume: ≤0. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.003DOI Listing
December 2018
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Regional volumetric abnormalities in pediatric autism revealed by structural magnetic resonance imaging.

Int J Dev Neurosci 2018 Dec 12;71:34-45. Epub 2018 Aug 12.

Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, 401 Park Dr., Boston, MA, 02215, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA, 02129, USA.

Autism is a group of complex neurodevelopmental disorders characterized by impaired social interaction, restricted and repetitive behavior. We performed a large-scale retrospective analysis of 1,996 structural magnetic resonance imaging (MRI) examinations of the brain from 1,769 autistic and neurologically typically developing patients (aged 0-32 years), and extracted regional volumetric measurements distributed across 463 brain regions of each patient. The youngest autistic patients (<2. Read More

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December 2018
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Maternal dairy fat diet does not influence neurotrophin levels and cognitive performance in the rat offspring at adult age.

Int J Dev Neurosci 2018 Dec 12;71:18-29. Epub 2018 Aug 12.

Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth Deemed University, Pune 411043, India. Electronic address:

Cognitive development may be influenced by maternal nutrition especially fats. Indian population is vegetarian and main source of fat is dairy. This study investigates the effect of dairy fat consumption during pregnancy in an animal model on fatty acids, brain neurotrophins (brain derived neurotrophic factor: BDNF; and nerve growth factor: NGF) and cognitive performance in adult offspring. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.08.002DOI Listing
December 2018
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Physical activity as an option to reduce adverse effect of EMF exposure during pregnancy.

Int J Dev Neurosci 2018 Dec 1;71:10-17. Epub 2018 Aug 1.

Department of Radiology and Surgery, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

The popularity of using wireless fidelity over the last decades increased apprehensions about impact of high frequency electromagnetic fields (EMF) on health. Most of previous studies mentioned adverse effect of EMF on cognitive processes, but so far, no study has provided a way to control adverse effects of EMF exposure. The purpose of this study was to examine the effect of Wi-Fi EMF and physical activity on spatial learning and motor function in pregnant rat's offspring. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.009DOI Listing
December 2018

Sex-specific effects of CB1 receptor antagonism and stress in adolescence on anxiety, corticosterone concentrations, and contextual fear in adulthood in rats.

Int J Dev Neurosci 2018 Oct 29;69:119-131. Epub 2018 Jul 29.

Department of Biological Sciences, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Ontario, L2S 3A1, Canada; Department of Psychology, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Ontario, L2S 3A1, Canada; Center for Neuroscience, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Ontario, L2S 3A1, Canada. Electronic address:

There is a paucity of research regarding the role of endogenous cannabinoid signalling in adolescence on brain and behaviour development. We previously demonstrated effects of repeated CB1 receptor antagonism in adolescence on socioemotional behaviours and neural protein expression 24-48 h after the last drug administration in female rats, with no effect in males. Here we investigate whether greater effects would be manifested after a lengthier delay. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.07.011DOI Listing
October 2018
9 Reads