4,498 results match your criteria International Journal of Colorectal Disease[Journal]


Antibiotic therapy for acute uncomplicated appendicitis: a systematic review and meta-analysis.

Int J Colorectal Dis 2019 Apr 19. Epub 2019 Apr 19.

Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Ernst-Grube-Str. 40, 06120, Halle (Saale), Germany.

Purpose: Appendectomy has been the gold standard for every form of appendicitis. In recent years, though, it has repeatedly been claimed that for acute uncomplicated appendicitis, antibiotic therapy can be an equivalent treatment. The aim of this meta-analysis was to determine if antibiotic therapy is a safe and effective alternative to appendectomy for acute uncomplicated appendicitis. Read More

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http://link.springer.com/10.1007/s00384-019-03296-0
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http://dx.doi.org/10.1007/s00384-019-03296-0DOI Listing
April 2019
1 Read

Lymph node yield, survival benefit, and safety of high and low ligation of the inferior mesenteric artery in colorectal cancer surgery: a systematic review and meta-analysis.

Int J Colorectal Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of General Surgery, Gansu Provincial Hospital, Donggang West Road, Lanzhou, 730000, People's Republic of China.

Purpose: The aim of this meta-analysis was to compare high inferior mesenteric artery (IMA) ligation (HL) with low IMA ligation (LL) for the treatment of colorectal cancer and to evaluate the lymph node yield, survival benefit, and safety of these surgeries.

Methods: PubMed, Embase, Cochrane Library, Web of Science, and China Biomedical Literature Database (CBM) were systematically searched for relevant articles that compared HL and LL for sigmoid or rectal cancer. We calculated the odds ratio (OR) with 95% confidence intervals (CIs) for dichotomous outcomes and the weighted mean difference (WMD) for continuous outcomes. Read More

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http://dx.doi.org/10.1007/s00384-019-03291-5DOI Listing
April 2019
1 Read

Resting vector volume measured before ileostomy reversal may be a predictor of major fecal incontinence in patients with mid or low rectal cancer: a longitudinal cohort study using a prospective clinical database.

Int J Colorectal Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea.

Purpose: Despite a high incidence of fecal incontinence following sphincter-preservation surgery (SPS), there are no definitive factors measured before ileostomy reversal that predict fecal incontinence. We investigated whether vector volume anorectal manometry before ileostomy reversal predicts major fecal incontinence following SPS in patients with mid or low rectal cancer.

Methods: This longitudinal prospective cohort study comprised 173 patients who underwent vector volume anorectal manometry before ileostomy reversal. Read More

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http://dx.doi.org/10.1007/s00384-019-03293-3DOI Listing
April 2019
1 Read

Systemic inflammatory response predicts oncological outcomes in patients undergoing elective surgery for mismatch repair-deficient colorectal cancer.

Int J Colorectal Dis 2019 Apr 16. Epub 2019 Apr 16.

Centre for Colorectal Disease, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.

Introduction: A variety of inflammatory scoring systems and their prognostic value have been reported in many solid organ cancers. This study aimed to examine the association between the systemic and local inflammatory responses, and oncological outcomes in patients undergoing elective surgery for mismatch repair-deficient (dMMR) phenotype colorectal cancer (CRC).

Materials And Methods: Consecutive patients undergoing resection for dMMR CRC were identified from a prospectively maintained database and compared with a cohort of patients with proficient mismatch repair system tumours. Read More

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http://dx.doi.org/10.1007/s00384-019-03274-6DOI Listing

Characterization of risk factors for floppy pouch complex in ulcerative colitis.

Int J Colorectal Dis 2019 Apr 11. Epub 2019 Apr 11.

Center for Inflammatory Bowel Disease, Digestive Disease and Surgery Institute-A31, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH, 44195, USA.

Background: Restorative proctocolectomy with ileal pouch-anal anastomosis can be associated with a variety of complications, including floppy pouch complex (FPC). FPC is defined as the presence of pouch prolapse, afferent limb syndrome, enterocele, redundant loop, and folding pouch on pouchoscopy or contrasted pouchogram. The main symptoms of patients with FPC are dyschezia, incomplete evacuation, and bloating. Read More

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http://dx.doi.org/10.1007/s00384-019-03282-6DOI Listing
April 2019
2 Reads

Impact and risk factors of non-adherence to 5-aminosalicylates in quiescent ulcerative colitis evaluated by an electronic management system.

Int J Colorectal Dis 2019 Apr 8. Epub 2019 Apr 8.

IBD Unit, Digestive Disease Department, University Clinic Hospital of Valencia, University of Valencia, Blasco Ibañez Av. 17, 46010, Valencia, Spain.

Background And Objective: To determine the impact of non-adherence to 5-Aminosalicylates (5-ASA) on the risk of flares and to identify risk factors of non-adherence.

Methods: Observational, cohort study of ulcerative colitis (UC) patients in clinical remission at least 6 months on 5-ASA monotherapy maintenance prescribed by an electronic management program. Adherence was considered when 80% of the prescribed 5-ASA had been dispensed at the pharmacy. Read More

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http://dx.doi.org/10.1007/s00384-019-03271-9DOI Listing
April 2019
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Arterial anatomy of the splenic flexure using preoperative three-dimensional computed tomography.

Int J Colorectal Dis 2019 Apr 6. Epub 2019 Apr 6.

Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Background: To perform a safe and precise laparoscopic surgery for the splenic flexure cancer, it is important for surgeons to gain a preoperative understanding of the running of the feeding artery of the splenic flexure. We evaluated the blood supply to the splenic flexure by using preoperative three-dimensional computed tomography (3D-CT).

Method: We retrospectively analyzed a total of 88 patients with colorectal cancer who underwent preoperative 3D-CT at our institutions between April 2016 and June 2017. Read More

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http://dx.doi.org/10.1007/s00384-019-03289-zDOI Listing
April 2019
1 Read

Meta-analysis of medial-to-lateral versus lateral-to-medial colorectal mobilisation during laparoscopic colorectal surgery.

Int J Colorectal Dis 2019 May 6;34(5):787-799. Epub 2019 Apr 6.

Department of General Surgery, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.

Objectives: To evaluate comparative outcomes of medial-to-lateral and lateral-to-medial colorectal mobilisation in patients undergoing laparoscopic colorectal surgery.

Methods: We conducted a systematic search of electronic databases and bibliographic reference lists. Perioperative mortality and morbidity, procedure time, length of hospital stay, rate of conversion to open procedure, and number of harvested lymph nodes were the outcome parameters. Read More

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http://dx.doi.org/10.1007/s00384-019-03281-7DOI Listing
May 2019
1 Read

Successful use of tissue expander and pelvic sling to exclude small bowel for high-dose pelvic irradiation.

Int J Colorectal Dis 2019 Apr 5. Epub 2019 Apr 5.

Division of Colorectal Surgery, University Surgical Cluster, National University Health System, 1E Kent Ridge Road, Singapore, 119228, Singapore.

Objective: Our study seeks to describe our surgical technique of the use of a tissue expander and a pelvic sling in order to perform high-dose pelvic irradiation without incurring radiation toxicity to the small bowel. High-dose radiation therapy for pelvic tumours comes at a risk of radiation toxicity to the small bowel. Our study discusses our novel surgical technique of compartmentalising the abdomen and the pelvis through the use of a tissue expander and pelvic sling to avoid small bowel radiation toxicity. Read More

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http://dx.doi.org/10.1007/s00384-019-03280-8DOI Listing
April 2019
3 Reads

Outcomes of endoscopic resection of large colorectal lesions subjected to prior failed resection or substantial manipulation.

Int J Colorectal Dis 2019 Apr 3. Epub 2019 Apr 3.

Department of Colorectal Surgery, King's College Hospital NHS Foundation Trust, London, UK.

Purpose: Injudicious attempts at resection and extensive sampling of large colorectal adenomas prior to referral for endoscopic resection (ER) are common. This has deleterious effects, but little is known about the outcomes following ER. We retrospectively analysed the outcomes of ER of large adenomas previously subjected to substantial manipulation. Read More

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http://dx.doi.org/10.1007/s00384-019-03285-3DOI Listing

Right-sided vs. left-sided obstructing colonic cancer: results of a multicenter study of the French Surgical Association in 2325 patients and literature review.

Int J Colorectal Dis 2019 Apr 2. Epub 2019 Apr 2.

Sorbonne Université, Assistance Publique Hôpitaux de Paris, Department of Digestive and Hepatopancreato-Biliary Surgery, Pitié Salpêtrière University Hospital, 47-83 Bd de l'Hôpital, 75651, Paris Cedex 13, France.

Purpose: Few studies compared management and outcomes of obstructing colonic cancer (OCC), according to the tumor site. Our aim was to compare patient and tumor characteristics, postoperative and pathological results, and oncological outcomes after emergency management of right-sided vs. left-sided OCC. Read More

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http://dx.doi.org/10.1007/s00384-019-03286-2DOI Listing
April 2019
3 Reads

Long-term outcome after segmental colonic resection for slow transit constipation.

Int J Colorectal Dis 2019 Apr 1. Epub 2019 Apr 1.

Institution of Surgical Sciences, Uppsala University Hospital, Uppsala University, SE 751 85, Uppsala, Sweden.

Purpose: Colectomy with ileorectal anastomosis (IRA) is the most common surgical procedure for slow transit constipation (STC). A hemicolectomy has been suggested as an alternative to IRA with good short-term results. However, long-term results are unknown. Read More

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http://dx.doi.org/10.1007/s00384-019-03283-5DOI Listing
April 2019
2 Reads

Comparison of surgical procedures implemented in recent years for patients with grade III and IV hemorrhoids: a network meta-analysis.

Int J Colorectal Dis 2019 Mar 30. Epub 2019 Mar 30.

Department of Anorectal Surgery, The First Hospital of China Medical University, Shenyang, 110000, China.

Purpose: This study aimed to investigate the complications and recurrence rates of the different surgical procedures implemented in recent years for the treatment of grade III and IV hemorrhoids using a network meta-analysis approach.

Methods: A systematic literature search was conducted for randomized clinical trials (RCTs) published from January 2013 to August 2018, via PubMed, Embase, the Cochrane Library, and Web of Science. Data related to anal stenosis, fecal incontinence, hemorrhoids thrombosis, and recurrence rates were extracted from the included studies, which were selected based on associations with surgical procedures for grade III and IV hemorrhoids. Read More

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http://link.springer.com/10.1007/s00384-019-03288-0
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http://dx.doi.org/10.1007/s00384-019-03288-0DOI Listing
March 2019
7 Reads

Epidural analgesia vs systemic opioids in patients undergoing laparoscopic colorectal surgery.

Int J Colorectal Dis 2019 May 29;34(5):915-921. Epub 2019 Mar 29.

Department of Anesthesiology, San Raffaele Hospital, Vita-Salute University, Via Olgettina 60, 20132, Milan, Italy.

Purpose: A well-controlled pain is one of the most important targets of enhanced recovery after surgery (ERAS) protocols. Recent studies questioned the role of TEA (thoracic epidural analgesia) in support of less invasive techniques, in particular in laparoscopic mini-invasive surgery. The aim of this study is to compare patients undergoing laparoscopic mini-invasive colorectal surgery and receiving different analgesic techniques. Read More

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http://dx.doi.org/10.1007/s00384-019-03284-4DOI Listing

Defining authorship in the era of big data collection and its consequences on the academic career.

Int J Colorectal Dis 2019 May 29;34(5):939-940. Epub 2019 Mar 29.

Dept of Emergency and Organ Transplantation, Surgical Unit " M Rubino", University Aldo Moro of Bari, Bari, Italy.

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http://dx.doi.org/10.1007/s00384-019-03287-1DOI Listing

Oncological outcome of peripartum colorectal carcinoma-a single-center experience.

Int J Colorectal Dis 2019 May 26;34(5):899-904. Epub 2019 Mar 26.

Division of Colon and Rectal Surgery, Assistant Professor of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Objectives: This study aimed to analyze disease presentation, management, and oncological outcomes of patients diagnosed with peripartum colorectal cancer (CRC).

Methods: Retrospective cohort study of all consecutive women of childbearing age (18-45 years) between 2002 and 2014 diagnosed with CRC adenocarcinoma at a tertiary academic institution. Patients who experienced pregnancy within 12 months of their diagnosis (peripartum period, group 1) were compared to the remaining patients of the cohort (group 2). Read More

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http://dx.doi.org/10.1007/s00384-019-03278-2DOI Listing
May 2019
1 Read

Study of histopathologic parameters to define the prognosis of stage II colon cancer.

Int J Colorectal Dis 2019 May 26;34(5):905-913. Epub 2019 Mar 26.

Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, University "La Sapienza", Rome, Italy.

Purpose: Stage II colon cancer (CC) represents a challenging scenario for the choice of adjuvant chemotherapy; here, histologic factors need to be weighed up to establish the risk of recurrence. Tumor budding (TB) has recently been indicated as a confident predictor of clinical outcome in CC. Likewise, the presence of poorly differentiated clusters (PDCs) in a tumor has been pointed out as a leading criterion of a tumor grading system. Read More

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http://link.springer.com/10.1007/s00384-019-03279-1
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http://dx.doi.org/10.1007/s00384-019-03279-1DOI Listing
May 2019
10 Reads

Uncovered versus covered stent in management of large bowel obstruction due to colorectal malignancy: a systematic review and meta-analysis.

Int J Colorectal Dis 2019 May 23;34(5):773-785. Epub 2019 Mar 23.

Department of General Surgery, North Manchester General Hospital, Manchester, M8 5RB, UK.

Purpose: To compare outcomes of uncovered stent and covered stent in management of large bowel obstruction secondary to colorectal malignancy.

Methods: We conducted a search of electronic databases identifying studies comparing outcomes of uncovered and covered stents in management of large bowel obstruction secondary to colorectal malignancy. The Cochrane risk-of-bias tool and the Newcastle-Ottawa scale were used to assess the included studies. Read More

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http://dx.doi.org/10.1007/s00384-019-03277-3DOI Listing
May 2019
1 Read

MTL, a composite measure for objectively profiling hospitals on surgical performance in colorectal cancer surgery.

Int J Colorectal Dis 2019 May 21;34(5):889-898. Epub 2019 Mar 21.

Department of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, University Heidelberg, Theodor-Kutzer-Ufer 1-3, 68135, Mannheim, Germany.

Purpose: MTL is a composite outcome measure based on routine administrative data defined as (a) postoperative mortality and/or (b) postoperative transfer to another hospital and/or (c) length of hospital stay ≥ the prespecified time period. Aim of the present study was to investigate MTL for profiling hospitals on surgical performance in colorectal cancer surgery, using data from the national registers of the German Society of General and Visceral Surgery (DGAV) and to determine the time interval for length of stay with the highest accuracy regarding major complications (Clavien-Dindo grade ≥ 3).

Methods: All patients undergoing colorectal cancer resection between January 2010 and February 2017 were included. Read More

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http://link.springer.com/10.1007/s00384-019-03273-7
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http://dx.doi.org/10.1007/s00384-019-03273-7DOI Listing
May 2019
3 Reads

Influence of social deprivation and remoteness on the likelihood of sphincter amputation for rectal cancer: a high-resolution population-based study.

Int J Colorectal Dis 2019 May 15;34(5):927-931. Epub 2019 Mar 15.

Department of Research, Caen University Hospital, Caen, France.

Background: Medical care in rectal cancer is subject to social inequality. According to the last French guidelines, a 1-cm distal margin below the lower pole of the rectal tumor is now considered sufficient. This extends the limits of the current sphincter preservation gold standard. Read More

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http://dx.doi.org/10.1007/s00384-019-03272-8DOI Listing

Prevalence and predictors of surgical site infections after bowel resection for Crohn's disease: the role of dual-ring wound protector.

Int J Colorectal Dis 2019 May 13;34(5):879-887. Epub 2019 Mar 13.

Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, China.

Purpose: Surgical site infections (SSIs) have become a leading cause of preventable morbidity and mortality in surgery. The aim was to evaluate the efficacy of a dual-ring wound protector to prevent the SSIs in Crohn's disease (CD) after bowel resection.

Methods: This retrospective observational study included all CD patients undergoing bowel resection at the Inflammatory Bowel Disease Center between January 2015 and June 2018 at Sir Run Run Shaw Hospital. Read More

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http://dx.doi.org/10.1007/s00384-019-03275-5DOI Listing
May 2019
3 Reads

Endoscopic detection and resection of dysplasia in inflammatory bowel disease-techniques with videos.

Int J Colorectal Dis 2019 Apr 11;34(4):569-580. Epub 2019 Mar 11.

Center for Interventional Endoscopy, Advent Health, University of Central Florida College of Medicine, 601 E Rollins Street, Orlando, FL, 32803, USA.

Background: Patients with ulcerative colitis and Crohn's colitis have an increased risk of developing dysplasia and colorectal cancer as compared to the general population; surveillance colonoscopy is recommended in this patient population.

Methods: This review of the published literature aimed to assess the published evidence.

Results: Detection of dysplasia requires examination of mucosa with targeted biopsies of the visible lesions as well as random biopsies to detect invisible lesions. Read More

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http://link.springer.com/10.1007/s00384-019-03269-3
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http://dx.doi.org/10.1007/s00384-019-03269-3DOI Listing
April 2019
4 Reads

Pulmonary metastasis in newly diagnosed colon-rectal cancer: a population-based nomogram study.

Int J Colorectal Dis 2019 May 11;34(5):867-878. Epub 2019 Mar 11.

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, No. 180, Fenglin Road, Shanghai, 200032, China.

Background: Colorectal cancer (CRC) has a high worldwide incidence with a tendency to metastasize to the lungs. We aimed to identify clinical factors related to lung metastasis (LM) and analyze the prognosis of patients after LM.

Methods: Multivariate logistic regression analysis was used to identify risk factors for LM from CRC. Read More

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http://dx.doi.org/10.1007/s00384-019-03270-wDOI Listing
May 2019
5 Reads

Nivolumab-induced immune-mediated colitis: an ulcerative colitis look-alike-report of new cases and review of the literature.

Int J Colorectal Dis 2019 May 3;34(5):861-865. Epub 2019 Mar 3.

Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.

Purpose: Nivolumab, a monoclonal antibody-targeting programmed cell death protein-1, is being increasingly used for the treatment of some advanced neoplasms. Several of its adverse effects are a result of the upregulation of T cells, with colitis as one of the most severe, and a challenging differential diagnosis with ulcerative colitis. However, few real-life clinical practice cases have been reported beyond trials. Read More

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http://dx.doi.org/10.1007/s00384-019-03268-4DOI Listing
May 2019
2 Reads

The prevalence of venous thromboembolism in rectal surgery: a systematic review and meta-analysis.

Int J Colorectal Dis 2019 May 1;34(5):849-860. Epub 2019 Mar 1.

Department of Surgery, James Connolly Memorial Hospital, Blanchardstown, Dublin, Ireland.

Purpose: Venous thromboembolism (VTE) following rectal surgery is a significant and preventable cause of morbidity and mortality, yet the true prevalence is not well established. This systematic review and meta-analysis assessed the available literature and determined its prevalence following rectal surgery.

Methods: A systematic review assessed the prevalence of VTE following rectal surgery. Read More

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http://dx.doi.org/10.1007/s00384-019-03244-yDOI Listing
May 2019
1 Read

Minimally invasive techniques in the management of pilonidal disease.

Int J Colorectal Dis 2019 Apr 27;34(4):561-568. Epub 2019 Feb 27.

St Helens and Knowsley NHS Foundation Trust, Whiston Hospital, Rainhill, Prescot, L35 5DR, England.

Background: Pilonidal sinus disease (PD) is a chronic condition involved in natal cleft. Excision surgery carries equally morbid course of recovery to that of disease itself. Minimally invasive treatments therefore have been developed to minimise morbidity and improve healing rates. Read More

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http://link.springer.com/10.1007/s00384-019-03260-y
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http://dx.doi.org/10.1007/s00384-019-03260-yDOI Listing
April 2019
6 Reads

Oncologic outcomes for low rectal adenocarcinoma following low anterior resection with coloanal anastomosis versus abdominoperineal resection: a National Cancer Database propensity matched analysis.

Int J Colorectal Dis 2019 May 21;34(5):843-848. Epub 2019 Feb 21.

Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Purpose: Low anterior resection with coloanal anastomosis (CAA) for low rectal cancer is a technically difficult operation with limited data available on oncologic outcomes. We aim to investigate overall survival and operative oncologic outcomes in patients who underwent CAA compared to abdominoperineal resection (APR).

Methods: The National Cancer Database (2004-2013) was used to identify patients with non-metastatic rectal adenocarcinoma who underwent CAA or APR. Read More

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http://dx.doi.org/10.1007/s00384-019-03267-5DOI Listing

Post-operative clinical, manometric, and defecographic findings in patients undergoing unsuccessful STARR operation for obstructed defecation.

Int J Colorectal Dis 2019 May 19;34(5):837-842. Epub 2019 Feb 19.

Department of Emergency and Organ Transplantation and Inter-Department Research Center for Pelvic Floor Diseases (CIRPAP), University "Aldo Moro" of Bari, Piazza G Cesare, 11, 70124, Bari, Italy.

Aim: To evaluate the reason for failure of STARR (stapled transanal rectal resection) operation for obstructed defecation.

Methods: A retrospective study (June 2012-December 2017) was performed using a prospectively maintained database of patients who underwent STARR operation for ODS (obstructed defecation syndrome), complaining of persisting or de novo occurrence of pelvic floor dysfunctions. Postoperative St Mark's and ODS scores were evaluated. Read More

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http://dx.doi.org/10.1007/s00384-019-03263-9DOI Listing

Endoscopic resection of colorectal circumferential and near-circumferential laterally spreading lesions: outcomes and risk of stenosis.

Int J Colorectal Dis 2019 May 19;34(5):829-836. Epub 2019 Feb 19.

Department of Colorectal Surgery, King's College Hospital NHS Foundation Trust, London, UK.

Purpose: Almost any colorectal superficial neoplastic lesion can be treated by endoscopic resection (ER) but very little is known about outcomes of ER leaving circumferential or near-circumferential mucosal defects. We report the outcomes of ER leaving ≥ 75% circumferential mucosal defects performed in a western expert centre.

Methods: Five hundred eighty-seven ERs of large colorectal lesions ≥ 20 mm were grouped according to the extent of the mucosal defect and comparisons made between those with < 75% and ≥ 75% defects. Read More

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http://dx.doi.org/10.1007/s00384-019-03254-wDOI Listing

Laparoscopic and open resection of rectal cancer-is age an effect modifier for short- and long-term survival?

Int J Colorectal Dis 2019 May 18;34(5):821-828. Epub 2019 Feb 18.

Klinik für Allgemein-, Viszeral-, Thoraxchirurgie und Adipositasmedizin, Caritas Krankenhaus St. Josef Regensburg, Landshuter Str. 65, 93053, Regensburg, Germany.

Introduction: Rectal cancer is a frequently diagnosed tumor worldwide. Various studies have shown the noninferiority or even slight superiority of laparoscopic resection. However, there is no clear recommendation on whether age should influence the choice of surgical approach. Read More

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http://dx.doi.org/10.1007/s00384-019-03265-7DOI Listing

Prevalence of alpha-1-antitrypsin deficiency carriers in a population with and without colonic diverticula. A multicentre prospective case-control study: the ALADDIN study.

Int J Colorectal Dis 2019 May 15;34(5):933-938. Epub 2019 Feb 15.

Department of Surgery, Northwest Clinics, Wilhelminalaan 12, 1815 JD, Alkmaar/Den Helder, Netherlands.

Purpose: The underling pathophysiological mechanisms that cause the formation of colonic diverticula (diverticulosis) remain unclear. Connective tissue changes due to ageing that cause changes in collagen structure of the colonic wall is one theory. Alpha-1-antitrypsin (A1AT) is a protease inhibitor known to protect connective tissue in other organs. Read More

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http://dx.doi.org/10.1007/s00384-019-03248-8DOI Listing
May 2019
1 Read

Correction to: Appendicitis as a manifestation of colon cancer: should we image the colon after appendicectomy in patients over the age of 40 years?

Int J Colorectal Dis 2019 04;34(4):771

Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, B9 5SS, UK.

The above article originally published with an error present in Table 1 and is now presented correctly in this article. Read More

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http://dx.doi.org/10.1007/s00384-019-03262-wDOI Listing

Appendicectomy in older patients with acute appendicitis is not an indication for routine colonoscopy.

Int J Colorectal Dis 2019 May 14;34(5):945. Epub 2019 Feb 14.

Department of Accident and Emergency, St Helens and Knowsley Hospitals NHS Trust, Prescot, UK.

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http://dx.doi.org/10.1007/s00384-019-03264-8DOI Listing
May 2019
1 Read

Long distance to hospital is not a risk factor for non-reversal of a defunctioning stoma.

Int J Colorectal Dis 2019 Feb 12. Epub 2019 Feb 12.

Department of Surgical and Perioperative Sciences, Umeå University, SE-901 88, Umeå, Sweden.

Purpose: To see if road distance to hospital influences stoma reversal rate, time from index operation to stoma reversal, and occurrence of permanent stoma.

Methods: Data from all diagnosed cases of rectal cancer from three counties in northern Sweden were extracted from the Swedish Rectal Cancer Registry. The three counties are sparsely populated, with a population density roughly one fifth the average density in Sweden. Read More

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http://dx.doi.org/10.1007/s00384-019-03258-6DOI Listing
February 2019
1 Read

Ileostomy versus fecal diversion device to protect anastomosis after rectal surgery: a randomized clinical trial.

Int J Colorectal Dis 2019 May 11;34(5):811-819. Epub 2019 Feb 11.

Department of Surgery, College of Medicine, Yeungnam University, 170, Hyeonchung-ro, Nam-gu, Daegu, 42415, South Korea.

Purpose: Patients with rectal anastomosis commonly experience various ileostomy-related complications. This study aimed to elucidate the usefulness of a fecal diversion device (FDD) as an alternative to ileostomy for protecting rectal anastomosis.

Methods: Patients with rectal anastomosis were randomly assigned to the ileostomy and FDD groups except in cases of emergency surgery. Read More

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http://link.springer.com/10.1007/s00384-019-03255-9
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http://dx.doi.org/10.1007/s00384-019-03255-9DOI Listing
May 2019
8 Reads

Clinical and endoscopic complications of Epstein-Barr virus in inflammatory bowel disease: an illustrative case series.

Int J Colorectal Dis 2019 May 9;34(5):923-926. Epub 2019 Feb 9.

Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Background And Aim: Epstein-Barr virus (EBV) is a proposed trigger in the etiopathogenesis of inflammatory bowel disease (IBD) and is associated with lymphoproliferative diseases. Nevertheless, testing for EBV DNA in the intestinal mucosa and screening for EBV infection before initiation of a drug therapy are not routinely performed. The aim of this article is to increase awareness of the relevance of EBV infection in specific clinical situations. Read More

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http://dx.doi.org/10.1007/s00384-019-03257-7DOI Listing
May 2019
1 Read

Prognostic significance of doubling time in patients undergoing radical surgery for metachronous peritoneal metastases of colorectal cancer.

Int J Colorectal Dis 2019 May 9;34(5):801-809. Epub 2019 Feb 9.

Department of Surgical Oncology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Purpose: The doubling times of tumor volume and tumor markers are associated with the prognosis of liver or lung metastases from colorectal cancer (CRC). However, no studies have assessed peritoneal metastases. Therefore, we aimed to elucidate the association between doubling time and the prognosis of patients who underwent radical surgery for metachronous peritoneal metastases of CRC. Read More

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http://dx.doi.org/10.1007/s00384-019-03259-5DOI Listing
May 2019
1 Read

Correction to: Short-term outcome of laparoscopic versus robotic ventral mesh rectopexy for full-thickness rectal prolapse. Is robotic superior?

Int J Colorectal Dis 2019 04;34(4):769

Department of Colorectal Surgery, Royal Liverpool and Broadgreen University Hospital NHS Trust, University of Liverpool, Liverpool, L7 8XP, UK.

The authors wish to clarify a number of points that were incorrectly stated in the original article. These changes do not invalidate the article. Read More

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http://dx.doi.org/10.1007/s00384-019-03247-9DOI Listing
April 2019
5 Reads

Refractory major LARS: stoma can wait.

Int J Colorectal Dis 2019 May 9;34(5):943-944. Epub 2019 Feb 9.

Department of General and Specialist Surgery, University of Naples Federico II, Via Pansini 5, 80131, Naples, Italy.

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http://dx.doi.org/10.1007/s00384-019-03261-xDOI Listing
May 2019
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To what extent is the low anterior resection syndrome (LARS) associated with quality of life as measured using the EORTC C30 and CR38 quality of life questionnaires?

Int J Colorectal Dis 2019 Apr 5;34(4):747-762. Epub 2019 Feb 5.

Department of General, Visceral and Thoracic Surgery, Dresden-Friedrichstadt General Hospital, Teaching Hospital of the Technical University of Dresden, Friedrichstr. 41, D-01067, Dresden, Germany.

Purpose: Treatment of rectal cancer often results in disturbed anorectal function, which can be quantified by the Low Anterior Resection Syndrome (LARS) score. This study investigates the association of impaired anorectal function as measured with the LARS score with quality of life (QoL) as measured with the EORTC-QLQ-C30 and CR38 questionnaires.

Methods: All stoma-free patients who had undergone sphincter-preserving surgery for rectal cancer from 2000 to 2014 in our institution were retrieved from a prospective database. Read More

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http://dx.doi.org/10.1007/s00384-019-03249-7DOI Listing
April 2019
2 Reads

Endoscopic pilonidal sinus treatment (EPSiT) in recurrent pilonidal disease: a prospective international multicenter study.

Int J Colorectal Dis 2019 Apr 4;34(4):741-746. Epub 2019 Feb 4.

Department of Surgery, EOC Hospital, Mendrisio, Switzerland.

Background: Pilonidal disease (PD) is a common disease of the natal cleft, which can lead to complications including infection and abscess formation. Various operative management options are available, but the ideal technique is still debatable. Recurrent PD after surgical treatment is frequent event for the 25-30% of cases. Read More

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http://link.springer.com/10.1007/s00384-019-03256-8
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http://dx.doi.org/10.1007/s00384-019-03256-8DOI Listing
April 2019
3 Reads

Determination of the transection margin during colorectal resection with hyperspectral imaging (HSI).

Int J Colorectal Dis 2019 Apr 2;34(4):731-739. Epub 2019 Feb 2.

Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstr. 20, D-04103, Leipzig, Germany.

Purpose: This study evaluated the use of hyperspectral imaging for the determination of the resection margin during colorectal resections instead of clinical macroscopic assessment.

Methods: The used hyperspectral camera is able to record light spectra from 500 to 1000 nm and provides information about physiologic parameters of the recorded tissue area intraoperatively (e.g. Read More

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http://dx.doi.org/10.1007/s00384-019-03250-0DOI Listing
April 2019
1 Read
2.449 Impact Factor

Three-dimensional high-resolution anorectal manometry in functional anorectal disorders: results from a large observational cohort study.

Int J Colorectal Dis 2019 Apr 31;34(4):719-729. Epub 2019 Jan 31.

Gastroenterology Department, North Hospital, Assistance Publique Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.

Background: The aim of the study was to describe the results of 3D high-resolution anorectal manometry (3DHRAM) in a large cohort of patients with functional anorectal disorders.

Methods: In this single-center retrospective study, all consecutive patients referred for investigation of fecal incontinence (FI) or dyssynergic defecation (DD) underwent 3DHRAM. The parameters analyzed were usual manometric data, repartition of dyssynergic patterns, and the prevalence of a new "muscular subtype classification" underlying dyssynergia, anal sphincter defects, and pelvic floor disorders. Read More

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http://dx.doi.org/10.1007/s00384-019-03235-zDOI Listing
April 2019
5 Reads

Appendix orifice polyps: a study of 691 lesions at a single institution.

Int J Colorectal Dis 2019 Apr 30;34(4):711-718. Epub 2019 Jan 30.

Department of Colorectal Surgery, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.

Purpose: Data on the management of appendix orifice lesions are limited. We present our experience on the management of appendix orifice lesions focusing on the range of size, histology, treatment, and outcomes for polyps at the appendix orifice.

Methods: Retrospective descriptive study at a tertiary referral center. Read More

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http://link.springer.com/10.1007/s00384-019-03251-z
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http://dx.doi.org/10.1007/s00384-019-03251-zDOI Listing
April 2019
12 Reads

Associations between multiple immunosuppressive treatments before surgery and surgical morbidity in patients with ulcerative colitis during the era of biologics.

Int J Colorectal Dis 2019 Apr 26;34(4):699-710. Epub 2019 Jan 26.

Division of Infection Control and Prevention, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Purpose: It is unclear whether immunomodulators or biologics, with the exception of corticosteroids, can be risk factors for postoperative infectious complications of ulcerative colitis (UC). Moreover, many immunosuppressive therapies including some biologics are used mainly to treat UC, and many patients are on multi-agent immunosuppressive therapy at the time of surgery. Therefore, we evaluated the influence of pre-operative multiple immunosuppressive agents on the occurrence of surgical site infection (SSI) in UC during the era of biologics. Read More

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http://dx.doi.org/10.1007/s00384-019-03253-xDOI Listing
April 2019
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Diverted versus undiverted restorative proctocolectomy for chronic ulcerative colitis: an analysis of long-term outcomes after pouch leak short title: outcomes after pouch leak.

Int J Colorectal Dis 2019 Apr 25;34(4):691-697. Epub 2019 Jan 25.

Department of Surgery, Icahn School of Medicine at Mount Sinai, 5 E 98th St., 15th Floor, New York, NY, 10029, USA.

Background: The safety of undiverted restorative proctocolectomy (RPC) is debated. This study compares long-term outcomes after pouch leak in diverted and undiverted RPC patients.

Methods: Data were obtained from a prospectively maintained registry from a single surgical practice. Read More

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http://dx.doi.org/10.1007/s00384-019-03240-2DOI Listing

Impact of the preoperative prognostic nutritional index on postoperative and survival outcomes in colorectal cancer patients who underwent primary tumor resection: a systematic review and meta-analysis.

Int J Colorectal Dis 2019 Apr 24;34(4):681-689. Epub 2019 Jan 24.

Department of Anorectal Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.

Purpose: We aimed to explore whether the preoperative prognostic nutritional index (PNI) could be an indicator of prognostic outcomes in colorectal cancer (CRC) patients.

Methods: A systematic review and meta-analysis was conducted using the PubMed, Embase, and Web of Science databases. All original comparative studies published in English that were related to a high PNI versus a low PNI in CRC patients were included. Read More

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http://dx.doi.org/10.1007/s00384-019-03241-1DOI Listing
April 2019
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What's wrong with the status quo? Plenty.

Int J Colorectal Dis 2019 May 24;34(5):941-942. Epub 2019 Jan 24.

UCSF ANCRE Center, Mount Zion Hospital, San Fracisco, California, USA.

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http://dx.doi.org/10.1007/s00384-019-03246-wDOI Listing

Predictors of toxicity-related hospitalization in four randomized studies of 5-fluorouracil-based chemotherapy in metastatic colorectal cancer.

Int J Colorectal Dis 2019 Apr 24;34(4):675-680. Epub 2019 Jan 24.

Department of Oncology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Objective: To evaluate the predictors of toxicity-related hospitalization associated with various chemotherapy regimens among metastatic colorectal cancer patients METHODS: This pooled analysis includes patient-level datasets from four randomized clinical studies (NCT00272051; NCT00305188; NCT00115765; NCT00364013). Through univariate and multivariate logistic regression analyses, factors predicting the development of serious adverse events, fatal adverse events, and toxicity-related hospitalizations were determined.

Results: A total of 2533 patients were included in the current study. Read More

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http://dx.doi.org/10.1007/s00384-019-03252-yDOI Listing
April 2019
2.449 Impact Factor

The relation between oncologic outcomes and metastatic lymph node location following laparoscopic resection of stage III colon cancer.

Int J Colorectal Dis 2019 Apr 23;34(4):667-673. Epub 2019 Jan 23.

Department of Surgery, Chonnam National University Hwasun Hospital, 322 Seoyang-ro, Hwasun-eup, Hwasun-gun, Jeonnam, 58128, Republic of Korea.

Purpose: Colon cancers are staged by assessing more than 12 lymph nodes, but there is still a controversy over the number of lymph nodes. Only a few studies of metastatic lymph node position in colon cancer have been published with its significance not completely understood. This study aimed to compare survival rates according to metastatic lymph node position following radical lymph node dissection for stage III colon cancers. Read More

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http://dx.doi.org/10.1007/s00384-019-03245-xDOI Listing
April 2019
2 Reads