1,317 results match your criteria International Journal of Clinical Pharmacy[Journal]


Consequences of ignoring patient diagnoses when using the 2015 Updated Beers Criteria.

Int J Clin Pharm 2019 Apr 24. Epub 2019 Apr 24.

Pharmacology and Pharmaceutical Care Laboratory, Faculdade de Farmácia, Universidade de Coimbra, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.

Background: Beers Criteria are one of the best known explicit criteria to identify inappropriate medication in elderly that can be used in medication review. The access to patients' medical records may be different among healthcare professionals and settings and, subsequently, the identification of patients' diagnoses may be compromised.

Objective: To assess the consequences of ignoring patient diagnoses when applying 2015 Beers Criteria to identify potentially inappropriate medication (PIM). Read More

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http://dx.doi.org/10.1007/s11096-019-00828-0DOI Listing

Optimizing pharmaceutical care for pediatric patients with dermatitis: perspectives of parents and pharmacy staff.

Int J Clin Pharm 2019 Apr 24. Epub 2019 Apr 24.

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB, Utrecht, The Netherlands.

Background Atopic dermatitis affects 10-20% of the children worldwide. Unfortunately not all patients who receive treatment have optimal treatment outcomes. Objective To assess the view of parents and pharmacy staff in order to optimize pharmaceutical care for young atopic dermatitis patients. Read More

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http://dx.doi.org/10.1007/s11096-019-00827-1DOI Listing

Attitudes towards deprescribing among multi-ethnic community-dwelling older patients and caregivers in Malaysia: a cross-sectional questionnaire study.

Int J Clin Pharm 2019 Apr 24. Epub 2019 Apr 24.

School of Pharmacy, Monash University, Building 2, Level 5, Room 38, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia.

Background Deprescribing describes a process of medication regimen optimization with the aim to reduce adverse events and improve quality of life. There is limited research on perceptions of older adults, defined as those 60 years of age and older, about their willingness to cease a medication in developing countries. Objective To ascertain patients' attitudes, beliefs, perceptions, and experiences regarding the number of medications they were taking and their opinions regarding deprescribing. Read More

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http://dx.doi.org/10.1007/s11096-019-00829-zDOI Listing

The effect of hospital-based antithrombotic stewardship on adherence to anticoagulant guidelines.

Int J Clin Pharm 2019 Apr 24. Epub 2019 Apr 24.

Department of Hospital Pharmacy, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.

Background Anticoagulant therapy is associated with a high risk of complications. Adherence to anticoagulant therapy protocols may lower this risk but adherence is often suboptimal. The introduction of a multidisciplinary antithrombotic team may improve adherence to anticoagulant guidelines among physicians. Read More

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http://dx.doi.org/10.1007/s11096-019-00834-2DOI Listing

The acceptability of a direct oral anticoagulant monitoring regimen among patients with atrial fibrillation: a pilot study.

Int J Clin Pharm 2019 Apr 17. Epub 2019 Apr 17.

Sydney Medical School, The University of Sydney, Edward Ford Building A27, Sydney, NSW, 2006, Australia.

Background The direct oral anticoagulants (DOACs) offer several advantages over warfarin in the management atrial fibrillation, including the provision of fixed dosing without a requirement for regular monitoring. Recently however the subject of DOAC monitoring has been probed after several post-hoc analyses demonstrated an association between plasma levels and efficacy and safety events. Objective The aim of this pilot study was to explore the acceptability of DOAC plasma monitoring amongst patients with atrial fibrillation and the factors that may influence these attitudes. Read More

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http://dx.doi.org/10.1007/s11096-019-00830-6DOI Listing

Patients participation in pharmaceutical care consultations in Brazil.

Int J Clin Pharm 2019 Apr 22. Epub 2019 Apr 22.

Universidade Federal de São João del-Rei (UFSJ), Rua Sebastião Gonçalves Coelho, 400 - Bairro Chanadour, Divinópolis, MG, CEP:35501-296, Brazil.

Background The effectiveness of pharmaceutical care has already been evidenced in several studies and scenarios; the lack of patient's consultation has been little explored in the literature. Unprovided care is a missed opportunity to offer care to another individual who needs attention to their health. The need for investigation of missed consultations in a Brazilian pharmaceutical care service arises. Read More

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http://dx.doi.org/10.1007/s11096-019-00823-5DOI Listing

Pharmacist-led medicine use review in community pharmacy for patients on warfarin.

Int J Clin Pharm 2019 Apr 22. Epub 2019 Apr 22.

Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.

Background Medicine use review by pharmacists has the potential to improve anticoagulation therapy management in patients on warfarin. Objective To develop, implement and evaluate a pharmacist-led medication use review service for patients on warfarin. Setting Six community pharmacies in Malta. Read More

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http://dx.doi.org/10.1007/s11096-019-00824-4DOI Listing

Unavailable prescriptions at Danish community pharmacies: A descriptive study.

Int J Clin Pharm 2019 Apr 17. Epub 2019 Apr 17.

Hospital Pharmacy Funen, Odense University Hospital, Solfaldsvej 38, Entrance 208, 5000, Odense C, Denmark.

Background Handling of unavailable prescriptions, i.e. prescriptions missing on the online server, is considered troublesome and time-consuming by community pharmacy staff and may result in both patient dissatisfaction and non-compliance. Read More

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http://link.springer.com/10.1007/s11096-019-00831-5
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http://dx.doi.org/10.1007/s11096-019-00831-5DOI Listing
April 2019
1 Read

Interrater reliability of a tool to assess omission of prescription and inappropriate prescriptions in paediatrics.

Int J Clin Pharm 2019 Apr 11. Epub 2019 Apr 11.

Department of Pharmacy, Robert-Debré Hospital AP-HP, Paris, France.

Background Potentially inappropriate medication (PIM) and potential prescription omission (PPO) are common issues in pharmacotherapy in vulnerable populations. A first tool to assess PIM's and PPO's targeting pediatric populations: POPI «Pediatrics Omission of Prescriptions and Inappropriate Prescriptions» was created in 2014. Objective This study aimed to evaluate inter-rater reliability between healthcare professionals who apply POPI. Read More

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http://dx.doi.org/10.1007/s11096-019-00819-1DOI Listing

A community pharmacist medicines optimisation service for patients with advanced cancer pain: a proof of concept study.

Int J Clin Pharm 2019 Apr 9. Epub 2019 Apr 9.

School of Pharmacy, Faculty of Life Sciences, University of Bradford, Richmond Building, Richmond Road, Bradford, West Yorkshire, BD7 1DP, UK.

Background Patients with advanced cancer commonly experience pain and it is least controlled in community settings. Community pharmacists in the UK already offer medicines optimisation consultations although not for this patient group. Objective To determine whether medicines consultations for patients with advanced cancer pain are feasible and acceptable. Read More

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http://dx.doi.org/10.1007/s11096-019-00820-8DOI Listing

Clinical pharmacy practice in the care of Chronic Kidney Disease patients: a systematic review.

Int J Clin Pharm 2019 Apr 9. Epub 2019 Apr 9.

School of Pharmacy & Life Sciences, Robert Gordon University, Aberdeen, Scotland, UK.

Background Clinical pharmacy services have potential to contribute significantly to the multidisciplinary team providing safe, effective and economic care for patients. Given recent practice developments (e.g. Read More

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http://link.springer.com/10.1007/s11096-019-00816-4
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http://dx.doi.org/10.1007/s11096-019-00816-4DOI Listing
April 2019
6 Reads

Usability and sensitivity of the risk of bias assessment tool for randomized controlled trials of pharmacist interventions.

Int J Clin Pharm 2019 Apr 9. Epub 2019 Apr 9.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal.

Background The Cochrane collaboration risk of bias assessment (RoB) tool is used in several fields to evaluate the methodological quality of studies. Its strengths and challenges are discussed. Objective To assess the sensitivity of the RoB tool in studies of pharmacist interventions. Read More

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http://link.springer.com/10.1007/s11096-019-00818-2
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http://dx.doi.org/10.1007/s11096-019-00818-2DOI Listing
April 2019
1 Read

Cost-effectiveness analysis of low versus high dose colistin in the treatment of multi-drug resistant pneumonia: a comment.

Int J Clin Pharm 2019 Apr 9. Epub 2019 Apr 9.

Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, 4th Floor, No 92, Karimkhan Zand Ave, Hafte Tir Sq, Tehran, Iran.

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http://link.springer.com/10.1007/s11096-019-00822-6
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http://dx.doi.org/10.1007/s11096-019-00822-6DOI Listing
April 2019
3 Reads

Direct patient care activities and interventions of emergency medicine pharmacists.

Int J Clin Pharm 2019 Apr 5. Epub 2019 Apr 5.

Emergency Services Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Background Emergency medicine (EM) pharmacists are increasingly recognized as integral team members in the care of emergency department (ED) patients but there is variability in the scope of direct patient care services. Objectives The primary objective was to categorize direct patient care activities and drug therapy recommendations. The secondary objectives were to categorize recommendations based on drug class and to determine the proportion of recommendations associated with Institute for Safe Medication Practices (ISMP) high-alert medications. Read More

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http://dx.doi.org/10.1007/s11096-019-00817-3DOI Listing
April 2019
1 Read

Medication-related issues associated with the documentation and administration of long-acting injectable antipsychotics.

Int J Clin Pharm 2019 Apr 3. Epub 2019 Apr 3.

Faculty of Pharmacy and Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC, 3052, Australia.

Background There are significant research gaps into understanding the extent of medication errors within mental health and variation in the uptake of standardised medication safety practices. Long-acting injectable antipsychotic (LAIA) preparations are a common treatment modality for the administration of antipsychotic medicines. Aim of the review To examine the literature on medication-related errors and practice issues associated with the documentation and administration of LAIAs. Read More

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http://dx.doi.org/10.1007/s11096-019-00814-6DOI Listing
April 2019
1 Read

Exploring physicians, nurses and ward-based pharmacists working relationships in a Swedish inpatient setting: a mixed methods study.

Int J Clin Pharm 2019 Apr 1. Epub 2019 Apr 1.

Department of Pharmacology and Clinical Neuroscience, Umeå University, 90187, Umeå, Sweden.

Background In Sweden there has been limited work investigating the integration and nature of collaborative relationships between pharmacists and other healthcare practitioners. Objective To explore the working relationships of physicians, nurses and ward-based pharmacists in a rural hospital after the introduction of a clinical pharmacy service. Setting General medical ward in a rural hospital in northern Sweden. Read More

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http://link.springer.com/10.1007/s11096-019-00812-8
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http://dx.doi.org/10.1007/s11096-019-00812-8DOI Listing
April 2019
6 Reads

Drug-related problems associated with community-dwelling older persons living alone in Singapore.

Int J Clin Pharm 2019 Apr 1. Epub 2019 Apr 1.

Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Blk S4A Level 3, Singapore, 117543, Singapore.

Background Older persons living alone have been associated with poorer health outcomes and higher mortality rate. However, little is known about the drug related problems (DRPs) faced by this population group in Singapore. Objectives This study aims to elucidate the prevalence and type of DRPs associated with older persons living alone. Read More

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http://dx.doi.org/10.1007/s11096-019-00813-7DOI Listing
April 2019
1 Read

Open access, at what costs?

Int J Clin Pharm 2019 Apr 1. Epub 2019 Apr 1.

, Zuidlaren, The Netherlands.

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http://dx.doi.org/10.1007/s11096-019-00806-6DOI Listing
April 2019
1 Read

The use of nephrotoxic drugs in patients with chronic kidney disease.

Int J Clin Pharm 2019 Mar 21. Epub 2019 Mar 21.

Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Nigeria.

Background The use of nephrotoxic drugs has the potential to accelerate the loss of kidney function and increase the risk of end-stage renal disease. Objectives To determine the prevalence of nephrotoxic drugs use in patients with chronic kidney disease at two major hospitals in Maiduguri and to evaluate the predictors of exposure to the contraindicated ones. Methods This retrospective study used data from the patients' medical records. Read More

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http://link.springer.com/10.1007/s11096-019-00811-9
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http://dx.doi.org/10.1007/s11096-019-00811-9DOI Listing
March 2019
4 Reads

Prospective survey-based study on the categorization quality of hospital pharmacists' interventions using DokuPIK.

Int J Clin Pharm 2019 Mar 20. Epub 2019 Mar 20.

Department of Family Medicine, McGill University, Montreal, QC, Canada.

Background There is a growing need to categorize pharmacists' interventions (PIs) in Germany to document their impact on solving or avoiding drug-related problems. Objective To validate the categorization of drug-related problems-one aspect of the categorical internet database DokuPIK, designed for recording routinely PIs. To identify case-specific predictive values. Read More

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http://dx.doi.org/10.1007/s11096-019-00785-8DOI Listing
March 2019
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The development of a role description and competency map for pharmacists in an interprofessional care setting.

Int J Clin Pharm 2019 Mar 16. Epub 2019 Mar 16.

Graduate School of Health, University of Technology Sydney, Level 4, Building 7, 67 Thomas St, Ultimo, P.O. Box 123, Sydney, NSW, 2007, Australia.

Background Pharmacists are increasingly being included as members of general practice primary care teams. To date, there have been few published studies describing the competencies of general practice (GP) pharmacists and establishing their subsequent educational needs. Aim of the review The aim of this literature review is to establish the activities of pharmacists in general practice to inform the development of a comprehensive role description and competency map. Read More

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http://dx.doi.org/10.1007/s11096-019-00808-4DOI Listing

The description and definition of Emergency Department Pharmacist Practitioners in the United Kingdom (the ENDPAPER study).

Int J Clin Pharm 2019 Mar 16. Epub 2019 Mar 16.

Division of Pharmacy and Optometry, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

Background Due to a shortage of emergency department doctors and nurses, hospitals have started to employ pharmacists who have additional clinical skills, known as Emergency Department Pharmacist Practitioners, to help deliver services. Objective To describe, compare and define the Emergency Department Pharmacist Practitioner role. Setting UK emergency departments. Read More

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http://dx.doi.org/10.1007/s11096-019-00799-2DOI Listing

Pharmacists' views on the upscheduling of codeine-containing analgesics to 'prescription only' medicines in Australia.

Int J Clin Pharm 2019 Mar 16. Epub 2019 Mar 16.

School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.

Background Codeine is the most commonly used opioid worldwide, and is available over-the-counter (OTC) in many countries. There is continual debate regarding the risk:benefit profile for OTC codeine. In Australia, codeine containing analgesics became 'prescription only medicine' from February 2018. Read More

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http://dx.doi.org/10.1007/s11096-019-00804-8DOI Listing

An evaluation of the role of practice pharmacists in Australia: a mixed methods study.

Int J Clin Pharm 2019 Mar 16. Epub 2019 Mar 16.

Gold Coast Health, Queensland Health, Brisbane, QLD, Australia.

Background The need for greater collaboration between pharmacists and general practitioners in Australia facilitated the development of the practice pharmacist role. Practice pharmacists work from within general practices to provide services to patients and health professionals to improve the quality use of medications. Objective To explore the perceptions of Australian accredited pharmacists and pharmacists already working in general practices about current roles, facilitators and barriers, and remuneration expectations of practice pharmacists. Read More

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http://dx.doi.org/10.1007/s11096-019-00807-5DOI Listing

Comparative effectiveness of statins in secondary prevention among the older people aged 75 years and over.

Int J Clin Pharm 2019 Mar 12. Epub 2019 Mar 12.

College of Pharmacy, Korea University, 251l Sejong-ro, Sejong, 30019, Republic of Korea.

Background While there is clear evidence for the benefit of statins in the secondary prevention of cardiovascular and cerebrovascular events, there is a lack of research on the effects of statin regimens in older patients aged 75 years and over. Objectives To compare the effectiveness of statin regimens in the secondary prevention of ischemic cardiovascular and cerebrovascular events among patients aged 75 years and over. Setting Claims data from the South Korean National Health Insurance Database from 2006 to 2014. Read More

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http://link.springer.com/10.1007/s11096-019-00810-w
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http://dx.doi.org/10.1007/s11096-019-00810-wDOI Listing
March 2019
7 Reads

Critical review of European Medicines Agency (EMA) assessment report and related literature on domperidone.

Int J Clin Pharm 2019 Mar 12. Epub 2019 Mar 12.

Center for Drug Research and Development and Pharmacokinetic Applications (ARGEFAR), Ege University, Izmir, Turkey.

European Medicines Agency (EMA) issued a final decision on September 01, 2014 that restricts the maximum daily dose of domperidone to 30 mg and treatment duration to 7 days. This paper presents a critical review of the scientific basis of the literatures having a role in the decision of EMA on domperidone with an approach based on statistical and epidemiological perspective. Although observational studies used by EMA were published, the EMA didn't use an algorithm including "randomized clinical trials" according to evidence-based medicine when presenting their results. Read More

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http://dx.doi.org/10.1007/s11096-019-00803-9DOI Listing

Impact of a pharmacy technician on clinical pharmacy services in an Australian hospital.

Int J Clin Pharm 2019 Mar 12. Epub 2019 Mar 12.

The University of Sydney School of Pharmacy, Faculty of Medicine and Health N508, Pharmacy and Bank Building A15, The University of Sydney, Camperdown, NSW, 2006, Australia.

Background There is increasing recognition for the role of pharmacy technicians in obtaining medication histories and performing administrative tasks which may represent an opportunity cost when completed by pharmacists. Technician-enhanced teams can therefore improve hospital clinical pharmacy services. In Australian hospitals, medication reconciliation and reviews can be documented in Medication Management Plans (MMPs) upon admission. Read More

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http://link.springer.com/10.1007/s11096-019-00801-x
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http://dx.doi.org/10.1007/s11096-019-00801-xDOI Listing
March 2019
4 Reads

Effects of sarpogrelate on microvascular complications with type 2 diabetes.

Int J Clin Pharm 2019 Mar 12. Epub 2019 Mar 12.

Division of Clinical Pharmacy, College of Pharmacy, Ajou University, 206 Worldcup-ro Yeongtong-gu, Suwon, 16499, Republic of Korea.

Background Diabetes is a major cause of microvascular complications. Renin-angiotensin-aldosterone blockers have been known to have the benefits of delaying onset and progression of diabetic complications including nephropathy. Objective To evaluate the effect of sarpogrelate, an antiplatelet agent, on the new onset diabetic complications in patients with type 2 diabetes mellitus. Read More

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http://link.springer.com/10.1007/s11096-019-00794-7
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http://dx.doi.org/10.1007/s11096-019-00794-7DOI Listing
March 2019
3 Reads

The value of pharmacists in general practice: perspectives of general practitioners-an exploratory interview study.

Int J Clin Pharm 2019 Mar 12. Epub 2019 Mar 12.

De Montfort University, Leicester, UK.

Background NHS England has recently invested on a large scale in the development of the role of pharmacists in general practice. Despite this initial funding, the perpetuation of pharmacists' roles ultimately relies on the funding and co-operation of GPs. Objective This study aimed to explore the perspectives of GPs with experience of fully funding a pharmacist in general practice, focussing on the value that GPs place on the role of the pharmacist. Read More

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http://dx.doi.org/10.1007/s11096-019-00795-6DOI Listing

Community pharmacists' opinions and practice of pharmaceutical care at chain pharmacy and independent pharmacy in China.

Int J Clin Pharm 2019 Mar 12. Epub 2019 Mar 12.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, N22-2057, Taipa, Macao, China.

Background Whether Chinese community pharmacists in chain pharmacies and independent pharmacies provide the same type and quality of pharmaceutical care has not been fully investigated. Objective This study aimed to investigate community pharmacists' understanding, attitude, practice and perceived barriers of pharmaceutical care at chain pharmacies and independent pharmacies in China. Setting Community pharmacies in China. Read More

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http://dx.doi.org/10.1007/s11096-019-00802-wDOI Listing

Impact of an oral nutrition protocol in patients treated with elective radical cystectomy: a long term follow-up.

Int J Clin Pharm 2019 Mar 12. Epub 2019 Mar 12.

Pharmacy Department, University Hospitals Leuven, Louvain, Belgium.

Background After radical cystectomy, delayed return of bowel function is relatively common. Although studies investigating on the best modality for delivering nutritional support to this patient group are limited, parenteral nutrition was standard of care in those patients at the urological ward of the University Hospitals Leuven. In 2015, we published the findings from our study conducted in patients undergoing elective regular radical cystectomy at the urological ward of the University Hospitals Leuven comparing the length of hospital stay in patients with early postoperative parenteral nutrition (n = 48) versus an immediate oral nutrition protocol (n = 46). Read More

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http://dx.doi.org/10.1007/s11096-019-00800-yDOI Listing

Impact of pharmacists' interventions on physicians' decision of a knowledge-based renal dosage adjustment system.

Int J Clin Pharm 2019 Mar 12. Epub 2019 Mar 12.

Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea.

Background Early interventions with clinical decision support system (CDSS) guidance have ensured appropriate drug dosing for patients with renal impairment. However, the low rates of physician compliance with CDSS alerts have been reported. Objective We investigated whether designated pharmacist interventions were associated with physician' acceptance of the knowledge-based renal dosage adjustment system (K-RDS) for patients with reduced renal function. Read More

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http://dx.doi.org/10.1007/s11096-019-00796-5DOI Listing
March 2019
2 Reads

Coeliac disease detection with an IgA/IgG-deamidated gliadin peptide based point of care test in community pharmacies.

Int J Clin Pharm 2019 Feb 16. Epub 2019 Feb 16.

Academic Department of Gastroenterology, Room P18, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, S10 2JF, UK.

Background Coeliac disease affects 1% of the population, but 75% remain undiagnosed. Objective To conduct a case finding feasibility and efficacy study for the detection of coeliac disease in community pharmacies. Setting Six community pharmacies across Sheffield, UK. Read More

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http://dx.doi.org/10.1007/s11096-019-00793-8DOI Listing
February 2019

Community pharmacists' role in preventing opioid substitution therapy-related deaths: a qualitative investigation into current UK practice.

Int J Clin Pharm 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacy and Pharmacology, University of Bath, C/O: 5 West 3.26, Claverton Down, Bath, BA2 7AY, UK.

Background Opioid substitution therapy involves prescribing of medical substitutes like methadone and buprenorphine to patients who are addicted to opioids. The majority of opioid substitution therapy dispensing in the UK is done by community pharmacists and they often see the patients on daily basis. It is unknown to what extent community pharmacists implement the policy to prevent overdose in patients receiving such treatment. Read More

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http://dx.doi.org/10.1007/s11096-019-00790-xDOI Listing
February 2019
1 Read

Hospitalization period and direct medical cost in patients using warfarin or novel oral anti-coagulants after a cerebral embolism.

Int J Clin Pharm 2019 Feb 5. Epub 2019 Feb 5.

Pharmacy Management Institute, 25-17, Sakuragaoka-cho, Shibuya-ku, Tokyo, 150-0031, Japan.

Background Warfarin has been used in Japan for a long time in patients after cerebral embolism to prevent recurrence. Recently, several novel oral anti-coagulants (NOACs) have been approved for use and are gradually replacing warfarin. However, it remains unclear whether warfarin and other NOACs differ from each other with respect to drug costs and length of stay (LOS) during treatment in Japan. Read More

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http://dx.doi.org/10.1007/s11096-019-00792-9DOI Listing
February 2019
1 Read

Factors associated with patient preferences towards deprescribing: a survey of adult patients on prescribed medications.

Int J Clin Pharm 2019 Feb 5. Epub 2019 Feb 5.

Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.

Background Deprescribing is a patient-centered intervention with inherent uncertainties and requires shared decision making and patient involvement. Objective In the present study, we aimed to investigate factors associated with patient preferences toward deprescribing in a representative sample in Japan. Methods We conducted a nationwide cross-sectional survey and used a quota sampling method to select representative samples of the Japanese general population. Read More

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http://dx.doi.org/10.1007/s11096-019-00797-4DOI Listing
February 2019
1 Read

Off-label use of tamoxifen in a Chinese tertiary care hospital.

Int J Clin Pharm 2019 Jan 25. Epub 2019 Jan 25.

Department of Pharmacy, Xiamen Maternity and Child Health Care Hospital, No. 10 Zhenhai Road, Xiamen, 361001, Fujian Province, China.

Background Tamoxifen is an estrogen receptor modulator used for the treatment of breast cancer; however, currently, it is used in many off-label indications. Objective To investigate the prevalence of tamoxifen off-label prescribing and explore available scientific evidence that supports those uses in outpatients. Setting Xiamen maternity and child health care hospital in Xiamen city of China. Read More

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http://dx.doi.org/10.1007/s11096-019-00788-5DOI Listing
January 2019
2 Reads

Polypharmacy in older patients at primary care units in Brazil.

Int J Clin Pharm 2019 Jan 25. Epub 2019 Jan 25.

Programa de Mestrado em Saúde Coletiva, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Rio de Contas 58, Quadra 17, Lote 58, Candeias, Vitória da Conquista, Bahia, 45055-090, Brazil.

Background Despite extensive studies of polypharmacy in older patients, no consensus regarding the definition of this practice exists in the literature. Several studies have defined polypharmacy as problematic when considering only the numbers of medications used by patients. Objective This study aimed to assess the prevalence of polypharmacy prescribing by comparing two different definitions (quantitative and qualitative) and evaluating factors associated with this practice in older patients. Read More

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http://dx.doi.org/10.1007/s11096-018-00780-5DOI Listing
January 2019

Usefulness of STOPP/START criteria to assess appropriateness of medicines prescribed to older adults in a resource-limited setting.

Int J Clin Pharm 2019 Jan 22. Epub 2019 Jan 22.

Department of Pharmacology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

Background There is a dearth of published data from resource-limited settings on appropriateness of medicines in older adults using explicit criteria, but it is unclear if the STOPP/START criteria can be helpful. Objective To assess the usefulness of STOPP/START criteria in assessing appropriateness of medicines in a resource-limited setting. Setting Medical, diabetic and psychiatric clinics of a tertiary care hospital and elderly living in a selected locality in Colombo district. Read More

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http://dx.doi.org/10.1007/s11096-019-00786-7DOI Listing
January 2019

Pharmacist-led academic detailing intervention in primary care: a mixed methods feasibility study.

Int J Clin Pharm 2019 Jan 22. Epub 2019 Jan 22.

Pharmaceutical Care Research Group, Cavanagh Pharmacy Building, School of Pharmacy, University College Cork, College Road, Cork, Republic of Ireland.

Background Academic detailing is a form of continuing medical education in which a trained health professional such as a physician or pharmacist visits prescribers in their practice to provide evidence-based information. While academic detailing has been adopted in other countries, this strategy is not routinely used in Ireland. Objective The aim of this study was to assess the feasibility and acceptability to General Practitioners (GPs) of a pharmacist-led academic detailing intervention in Ireland. Read More

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http://dx.doi.org/10.1007/s11096-019-00787-6DOI Listing
January 2019
2 Reads

Utilization of venous thromboembolism prophylaxis in American hospitalized pregnant women undergoing cesarean section.

Int J Clin Pharm 2019 Feb 19;41(1):264-271. Epub 2019 Jan 19.

Department of Obstetrics and Gynecology, University of California, Davis Medical Center, 2315 Stockton Blvd, Sacramento, CA, 95817, USA.

Background Pregnancy-related venous thromboembolism (VTE) is a leading preventable cause of maternal mortality in the United States; however, American guidelines for pharmacologic VTE prophylaxis remain less aggressive than other developed countries. The Safe Motherhood Initiative (SMI) combines aspects of American and international guidelines to increase utilization of prophylaxis and thereby decrease incidence of pregnancy-related VTE. Objectives To evaluate the prescribing and administration rates of pharmacologic VTE prophylaxis for women undergoing cesarean section (c-section) when retrospectively applying the SMI recommendations. Read More

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http://dx.doi.org/10.1007/s11096-018-00779-yDOI Listing
February 2019
2 Reads

Cost-effective analysis of low- versus high-dose colistin in the treatment of multi-drug resistant pneumonia in Saudi Arabia.

Int J Clin Pharm 2019 Feb 19;41(1):1-2. Epub 2019 Jan 19.

Skaggs School of Pharmacy and Pharmaceutical Science, University of California San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1007/s11096-019-00783-wDOI Listing
February 2019
2 Reads

Comparative efficacy of ivabradine versus beta-blockers in patients with mitral stenosis in sinus rhythm: systematic review and meta-analysis.

Int J Clin Pharm 2019 Feb 18;41(1):22-29. Epub 2019 Jan 18.

Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background Patients with mitral valve stenosis have increased heart rate. HR reduction is known as an important treatment and therapy strategy for patients with mitral valve stenosis. Aim of the review The aim of this systematic review and meta-analysis was to compare the efficacy of ivabradine versus beta-blockers in patients with mitral stenosis in sinus rhythm. Read More

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http://dx.doi.org/10.1007/s11096-018-00778-zDOI Listing
February 2019
3 Reads

DEFEAT-polypharmacy: deprescribing anticholinergic and sedative medicines feasibility trial in residential aged care facilities.

Int J Clin Pharm 2019 Feb 18;41(1):167-178. Epub 2019 Jan 18.

University of Bath, Bath, Somerset, UK.

Background Prolonged use of anticholinergic and sedative medicines is correlated with worsening cognition and physical function decline. Deprescribing is a proposed intervention that can help to minimise polypharmacy whilst potentially improving several health outcomes in older people. Objective This study aimed to examine the feasibility of implementing a deprescribing intervention that utilises a patient-centred pharmacist-led intervention model; in order to address major deprescribing challenges such as general practitioner time constraints and lack of accessible deprescribing guidelines and processes. Read More

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http://dx.doi.org/10.1007/s11096-019-00784-9DOI Listing
February 2019
1 Read

Perceived roles and barriers in caring for the people who are homeless: a survey of UK community pharmacists.

Int J Clin Pharm 2019 Feb 18;41(1):215-227. Epub 2019 Jan 18.

School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, UK.

Background Community pharmacists can be an accessible source for advice and support for the people who are homeless, given their utilisation of a variety of currently available services such as dispensing of medicines, drugs and alcohol services. Objective To determine community pharmacists' training, experiences and behavioural determinants in counselling and management of homeless population. Setting UK community pharmacies. Read More

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http://dx.doi.org/10.1007/s11096-019-00789-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394502PMC
February 2019
1 Read

Infectious diseases physician attitudes to long-term antibiotic use.

Int J Clin Pharm 2019 Feb 17;41(1):18-21. Epub 2019 Jan 17.

Monash Health, Clayton, VIC, Australia.

Background In Australia, it is not known how much antibiotic prescribing by infectious diseases physicians is long-term, or how confident they are with the evidence behind this practice. Objective Survey Australian infectious diseases physicians to assess attitudes and prescribing practice prescribing prolonged courses of antibiotics. Methods An online questionnaire was distributed to the mailing group for the Australian Society of Infectious Diseases. Read More

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http://dx.doi.org/10.1007/s11096-018-00781-4DOI Listing
February 2019
3 Reads

The clinical effects of CYP2C19 *2 allele frequency on Palestinian patients receiving clopidogrel after percutaneous coronary intervention.

Int J Clin Pharm 2019 Feb 17;41(1):96-103. Epub 2019 Jan 17.

Faculty of Medicine, the Islamic University of Gaza, Gaza, Palestine.

BackgroundCYP2C19 loss-of-function polymorphic alleles (*2 and *3) have been documented to impair clopidogrel metabolism, and represent a risk factor for major adverse cardiac events. CYP2C19 polymorphism exhibits marked ethnic heterogeneity. Objective To determine the prevalence of CYP2C19 *2 and *3 alleles in a cohort of Palestinian patients managed with percutaneous coronary intervention and dual antiplatelet therapy, and to determine their role in causing major adverse cardiac events. Read More

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http://link.springer.com/10.1007/s11096-018-00782-3
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http://dx.doi.org/10.1007/s11096-018-00782-3DOI Listing
February 2019
8 Reads

Identify and categorize drug-related problems in hospitalized surgical patients in China.

Int J Clin Pharm 2019 Feb 4;41(1):13-17. Epub 2019 Jan 4.

Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing, China.

Background Data is lacking on types and severities of drug-related problems (DRPs) in hospitalized surgical patients in China. Objective To identify and categorize types and causes of DRPs, and to assess severities of these DRPs. Setting An academic teaching hospital in Chongqing, China. Read More

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http://link.springer.com/10.1007/s11096-018-0777-7
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http://dx.doi.org/10.1007/s11096-018-0777-7DOI Listing
February 2019
4 Reads