929 results match your criteria International Journal of Clinical Pharmacology Research[Journal]


Breath alcohol concentrations in Japanese outpatients following paclitaxel and docetaxel infusion.

Int J Clin Pharmacol Res 2005 ;25(4):195-202

Department of Respiratory Disease, Saitama Cancer Center, Japan.

Patients receiving paclitaxel or docetaxel also receive a significant amount of ethanol, as both products contain ethanol as solvent. Patients in our clinics have occasionally exhibited signs of alcohol intoxication immediately after paclitaxel infusion. In 2002, the Japanese government lowered the minimum ethanol concentration for the definition of drunk driving, with the threshold breath alcohol concentration (BRAC) of 0. Read More

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February 2006
8 Reads

Effects of ranitidine on quality of gastric ulcer healing compared with famotidine: a randomized, controlled, multicenter trial.

Int J Clin Pharmacol Res 2005 ;25(4):187-94

Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Abeno-ku, Japan.

Ranitidine has been found to have anti-inflammatory action as well as antisecretory action in experimental models. However, there are no reports in human gastric ulcer. The aim of this study was to investigate the effects of ranitidine compared with those of famotidine on the quality of gastric ulcer healing. Read More

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February 2006
4 Reads

The effect of D-003 (10 mg/day) on biochemical parameters of bone remodelling in postmenopausal women: a randomized, double-blind study.

Int J Clin Pharmacol Res 2005 ;25(4):175-86

Medical-Surgical Research Center, Havana City, Cuba.

Biphosphonates, which are antiresorptive agents used to treat osteoporosis, inhibit the mevalonate pathway, preventing protein prenylation and inhibiting osteoclast activity. Statins decrease cholesterol biosynthesis by blocking the mevalonate pathway and have been reported to have beneficial effects on bone. D-003 is a mixture of high molecular weight acids purified from sugarcane wax that inhibits cholesterol biosynthesis before mevalonate production. Read More

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February 2006
3 Reads

Evaluation of cytokine serum levels in patients with plaque-type psoriasis.

Int J Clin Pharmacol Res 2005 ;25(4):169-73

Department of Dermatology, University of Thessaly, Larissa, Greece.

Psoriasis is a chronic debilitating cutaneous disorder that affects both sexes and appears clinically as inflamed, edematous skin lesions covered with a silvery white scale. Strong evidence suggests that immune mechanisms are implicated in its pathogenesis, such as persistent activation of T-lymphocytes, excessive proliferation of keratinocytes and reactivation of proto-oncogenes and other elements. Additionally, several recent studies have demonstrated that cytokines play a significant role in the pathogenesis of the disease, as they can be found in the affected skin of psoriatic patients. Read More

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February 2006
4 Reads

Treatment of guttate psoriasis with a new two-compound product containing calcipotriol and betamethasone dipropionate.

Int J Clin Pharmacol Res 2005 ;25(4):165-8

Department of Dermatology, Aristotle University of Thessaloniki, Greece.

We report a case of guttate psoriasis in a 28-year-old woman who had been suffering from scalp psoriasis from the age of 14. After an upper respiratory infection she presented with the typical exanthema of guttate psoriasis. Despite initial treatment with antibiotics and emollients, the rash continued to spread. Read More

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February 2006
5 Reads

Etanercept for psoriasis: two case reports.

Int J Clin Pharmacol Res 2005 ;25(4):159-63

Dermatology Department, Desterro Hospital, Lisbon, Portugal.

Psoriasis is a chronic inflammatory skin disorder. Recent advances in the understanding of its immunological basis have led to its redefinition as being T-cell mediated. New biological agents have been developed as effective selective target therapies and promise to be an alternative to conventional systemic medications. Read More

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February 2006
5 Reads

Evaluation of hepatitis B surface antigen, anti-hepatitis C virus and anti-human immunodeficiency virus antibodies and syphilis seropositivity in blood donors: six years' seropositivity.

Int J Clin Pharmacol Res 2005 ;25(3):155-8

Department of Microbiology, School of Vocational Health Services, Celal Bayar University, Manisa, Turkey.

This retrospective study was carried out to evaluate the seropositivity of hepatitis B surface antigen (HbsAg), anti-hepatitis C virus (HCV), anti-human immunodeficiency virus (HIV) and syphilis in blood donors in Manisa Government Hospital. Data were evaluated in 10,189 blood donors between April 1, 1997, which is the time from which regular records began to be collected, and April 1, 2003. The blood samples of the blood center from April 1, 1997, to January 1, 1998, were examined via the card method, those between January 1, 1998, and January 1, 2002, were examined via micro enzyme-linked immunosorbent assay (ELISA) method and the rest were evaluated with macro ELISA methods. Read More

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January 2006
5 Reads

Is there an association between clinical symptoms and intestinal parasitic infections?

Int J Clin Pharmacol Res 2005 ;25(3):151-4

Celal Bayar University School of Health Sciences, Manisa, Turkey.

Intestinal parasitic infections are major causes of childhood diseases in rural regions. The significant causes of this problem are the insufficient resources to improve the infrastructure in these regions and inadequate health services in both the diagnosis and treatment of diseases. The aim of this study was to assess the association between intestinal parasitic infections and clinical symptoms of infected children. Read More

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January 2006
4 Reads

Identification of human papillomavirus DNA in melanoma biopsy specimens of Greek population.

Int J Clin Pharmacol Res 2005 ;25(3):145-50

Department of Dermatology, University of Thessaly, Larissa, Greece.

The aim of this retrospective study was to evaluate melanoma biopsy specimens from the Greek population living in the prefecture of Larissa for the presence of human papillomavirus (HPV) DNA and to determine the possible relationship between HPV and clinical outcome in these patients. Twenty-eight melanoma biopsy specimens, 20 from primary cutaneous melanoma and eight from melanoma metastasis were obtained from 28 patients. The biopsy samples were formalin-fixed and paraffin wax-embedded. Read More

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January 2006
4 Reads

Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric acid in weight control.

Int J Clin Pharmacol Res 2005 ;25(3):133-44

Department of Physiology and Biophysics, Georgetown University Medical Center, Basic Science Building, Room 231 B, 4000 Reservoir Rd., N.W., Washington, DC 20057, USA.

The weight-loss efficacy of a novel, water-soluble, calcium-potassium salt of (-)-hydroxycitric acid (HCA-SX) was re-examined in 90 obese subjects (BMI: 30-50.8 kg/m2). We combined data from two previously reported randomized, double-blind, placebo-controlled clinical studies in order to achieve a better statistical evaluation based on a larger population. Read More

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January 2006
28 Reads

High bone-binding capacity of ibandronate in hemodialysis patients.

Int J Clin Pharmacol Res 2005 ;25(3):123-31

Medizinische Klinik A, Klinikum der Stadt Ludwigshafen GmbH, Ludwigshafen am Rhein, Germany.

Bisphosphonates are a potential therapy for osteoclast-mediated bone disease, such as renal osteodystrophy. This study evaluated ibandronate bone-binding in patients with secondary hyperparathyroidism and renal osteodystrophy and examined whether there is a correlation with bone metabolism parameters. Sixteen patients with end-stage renal disease and secondary hyperparathyroidism receiving regular hemodialysis were recruited to this 12-week trial. Read More

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January 2006
5 Reads

Phase II study of a novel oral formation of 5-fluorouracil in combination with low-dose cisplatin as preoperative chemotherapy of oral squamous cell carcinoma.

Int J Clin Pharmacol Res 2005 ;25(3):115-22

Second Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Osaka, Japan.

TS-1 is a novel oral 5-fluorouracil containing tegaful (prodrug of 5-FU) and two biochemical modulators. These modulators feature effect-enhancing and adverse reaction-reducing activity. We investigated the histological response and toxicities of combination chemotherapy with TS- 1 and low-dose cisplatin and evaluated its usefulness as preoperative chemotherapy Forty-four newly diagnosed patients with stage Il-IV oral squamous cell carcinoma were enrolled in this study from February 2002 to April 2004. Read More

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January 2006
5 Reads

Attenuated insulin response and normal insulin sensitivity in lean patients with ankylosing spondylitis.

Int J Clin Pharmacol Res 2005 ;25(3):107-14

Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia.

Chronic low-grade inflammation is associated with insulin resistance. The aim of this study was to determine insulin response to intravenous glucose load and insulin sensitivity in patients with ankylosing spondylitis (AS). Fourteen nonobese male patients with AS and 14 matched healthy controls underwent frequent-sampling intravenous glucose tolerance test (FSIVGTT). Read More

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January 2006
4 Reads

Methotrexate-induced acute lung injury in a patient with rheumatoid arthritis.

Int J Clin Pharmacol Res 2005 ;25(3):101-5

Division of Rheumatic Diseases, Tokyo Metropolitan Bokutoh Hospital, Koutohbashi, Sumida-ku, Tokyo, Japan.

Methotrexate (MTX)-induced acute lung injury developed in a female patient with rheumatoid arthritis. She was successfully treated with high-dose glucocorticoid therapy. During her hospital stay, the serum concentration of surfactant protein (SP)-D, which was markedly elevated on admission, was finally normalized and the disease resolved. Read More

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January 2006
4 Reads

Prevalence of DRB1*01 and DRB1*04 alleles in a group of patients with rheumatoid arthritis living in Liguria.

Int J Clin Pharmacol Res 2005 ;25(3):95-9

DISEM, University of Genoa, Rheumatology Center, Bruzzone Institute, Genoa, Italy.

A major component of genetic susceptibility to rheumatoid arthritis (RA) appears to be explained by inheritance of HLA-DRB1 alleles. Multiple HLA-DRB1 alleles (DRB1*0401, *0404, *0405, *0408, *0101, *102, *1001 and *1402) encoding a shared epitope at amino acid positions 70-74 are associated with susceptibility to RA. There is ethnic variation in the clinical expression of RA and in both the frequency and type of HLA-DRB1 alleles carrying the shared epitope. Read More

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January 2006
5 Reads

Production of matrix metalloproteinases and their inhibitors in osteoarthritic patients undergoing mud bath therapy.

Int J Clin Pharmacol Res 2005 ;25(2):77-94

Postgraduate School of Medical Hydrology, Department of Internal Medicine, Faculty of Medicine, University of Pavia, Italy.

Several studies have demonstrated that matrix metalloproteinases (MMPs) are frequently implicated in the destruction of articular cartilage in arthritis. The control of MMP activity is dependent on the local concentration of tissue inhibitors of metalloproteinases (TIMPs), and the imbalance of the enzyme-to-inhibitor ratios plays an important role in the remodeling of articular tissues. Some cytokines such as interleukin (IL)-1 and tumor necrosis factor (TNF)-alpha which regulate leukocyte activities, promote MMP secretion and, as a consequence, cartilage degradation. Read More

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October 2005
5 Reads

Interferon-beta induction/interferon-alpha2b plus ribavirin therapy in patients with chronic hepatitis C.

Int J Clin Pharmacol Res 2005 ;25(2):71-6

Division of Molecular Medicine & Medical Genetics, International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Kobe, Japan.

Treatment of chronic hepatitis C virus (HCV) infection with interferon (IFN) and ribavirin improves the rate of eradication of the virus by less than 20% in patients with genotype 1b and a high viral load. In this study we assessed whether IFN-beta induction/IFN-alpha2b plus ribavirin enhances the efficacy of the therapy in patients with chronic hepatitis C. The efficacy of IFN-beta induction/IFN-alpha2b plus ribavirin therapy (group A, n=7) was compared with that of IFN-alpha2b plus ribavirin (group B, n=7) in 14 patients with high levels of HCV-RNA (> 100 K/U/ml). Read More

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October 2005
5 Reads

The effect of short-term treatment with atorvastatin on E-selectin levels in severely burned patients.

Int J Clin Pharmacol Res 2005 ;25(2):65-9

Department of General Surgery, Atatirk University Medical Faculty, Erzurum, Turkey.

Cellular adhesion molecules are expressed by activated endothelial cells in severe bum. The release of these molecules can lead to organ damage. We measured E-selectin levels in the blood of 20 severe-burn patients. Read More

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October 2005
5 Reads

Effect of inhaled combination therapy on asthma management.

Int J Clin Pharmacol Res 2005 ;25(2):57-63

Institute of Lung Disease, Respiratory Unit, San Paolo Hospital, University of Milan, Italy.

The growing use of guidelines to manage asthmatic patients prompted us to evaluate their impact on clinical practice. This study was performed in two similar groups of asthmatic patients. A retrospective and prospective review of medical records in an asthmatic population was performed. Read More

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October 2005
4 Reads

Urinary pharmacokinetics of cyanidin glycosides in healthy young men following consumption of elderberry juice.

Int J Clin Pharmacol Res 2005 ;25(2):47-56

Solvay Pharmaceuticals GmbH, Hans-Boeckler-Allee 20, D-30173 Hannover, Germany.

We investigated the urinary pharmacokinetics of monomeric anthocyanins in seven healthy volunteers. The volunteers were administered a single oral dose of 3.57 g total anthocyanins contained in 150 ml of a concentrated elderberry juice under fasting conditions. Read More

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October 2005
6 Reads

Effects of D-003, a mixture of very long chain fatty acids purified from sugar cane wax, at 5 and 10 mg/day on platelet aggregation in healthy volunteers.

Int J Clin Pharmacol Res 2005 ;25(1):29-39

Center for Natural Products of the National Center for Scientific Research, Havana City, Cuba.

D-003 is a mixture of high molecular weight aliphatic primary acids purified from sugar cane wax with antiplatelet and cholesterol-lowering effects. Previous studies showed that D-003 (10-20 mg/day) administered for a short time inhibits platelet aggregation, 14 days being the longest duration investigated. This study was conducted to investigate the effects of D-003 (5 and 10 mg/day) for 30 days on platelet aggregation in normocholesterolemic subjects. Read More

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July 2005
4 Reads

Telmisartan has the strongest binding affinity to angiotensin II type 1 receptor: comparison with other angiotensin II type 1 receptor blockers.

Int J Clin Pharmacol Res 2005 ;25(1):41-6

Pharmacology Laboratory, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Japan.

There is a growing body of evidence that the renin-angiotensin system (RAS) plays a pivotal role in the pathogenesis of cardiovascular diseases. Indeed, large clinical trials have demonstrated a substantial benefit of the blockade of this system for cardiovascular-organ protection. Although several types of angiotensin II type 1 (AT1) receptor blockers (ARBs) are commercially available for the treatment of patients with hypertension, comparisons of the binding affinity to AT1 receptor among them remain to be elucidated. Read More

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July 2005
37 Reads

Treatment with oral biphosphonates can increase the sensitivity of sestamibi radionuclide imaging in patients with primary hyperparathyroidism.

Int J Clin Pharmacol Res 2005 ;25(1):19-28

Department of Endocrinology and Metabolism, "G Gennimatas" General Hospital, Athens, Greece.

The sensitivity of 99mTc-sestamibi scan in detecting parathyroid disease in primary hyperparathyroidism (PHP) is almost 90%, and therefore facilitates successful parathyroidectomy. To enhance the diagnostic accuracy of the procedure, we repeated imaging with 99mTc-sestamibi in 15 patients with PHP and an initially negative (11 patients) or weakly positive (four patients) 99mTc-sestamibi scan after the administration of 10 mg of oral alendronate for 2 months. Serum calcium, phosphate and parathormone (PTH) measurements were obtained at presentation and after 1 and 2 months' treatment with alendronate. Read More

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July 2005
3 Reads

Early and late effect of infliximab on circulating dendritic cells phenotype in rheumatoid arthritis patients.

Int J Clin Pharmacol Res 2005 ;25(1):9-18

Department of Rheumatology and Internal Medicine, St Maria Hospital, Bucharest, Romania.

The aim of this study was to analyze the phenotype of circulating dendritic cells (DCc) in rheumatoid arthritis (RA) patients before and after treatment with infliximab (at 24 h and 6 months) and the correlation between these changes and the clinical response to treatment. Sixteen patients with RA were recruited and clinical status was determined using the Disease Activity Score 28 (DAS28). All patients had active disease (mean DAS28 = 5. Read More

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July 2005
7 Reads

Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis.

Int J Clin Pharmacol Res 2005 ;25(1):1-7

Santos Rheumatology Clinic, San Pablo, Brazil.

Viscosuppplementation with intra-articular hyaluronic acid (hyaluronan [HA]) is a relatively new option for improving pain and articular function in patients with symptomatic knee osteoarthritis. An open multi-center study was performed in 365 patients with definite and symptomatic knee osteoarthritis from seven Latin American countries. Five doses of HA were administered once a week. Read More

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July 2005
5 Reads

Molecular mechanism for accelerated atherosclerosis in diabetes and its potential therapeutic intervention.

Int J Clin Pharmacol Res 2004 ;24(4):129-34

Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan.

Diabetes is associated with a marked increase in the risk of atherosclerotic vascular disorders, including coronary, cerebrovascular and peripheral artery disease. Macrovascular complications could account for disabilities and high mortality rates in patients with diabetes. There is a growing body of evidence to indicate that tight blood glucose control has no more than a marginal impact on cardiovascular disease in diabetes. Read More

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June 2005
5 Reads

Working women are better responders to beta-blocker monotherapy of mild hypertension than men.

Int J Clin Pharmacol Res 2004 ;24(4):123-8

II Ischemic Heart Disease Department, Institute of Cardiology, Warsaw, Poland.

The aim of this single-blind study was to compare the efficacy of betaxolol treatment (20 mg/day) on 24-h blood pressure profiles in working men and women with mild hypertension (grade 1 acc. ESH/ESC/JNC 2003), A group of 11 men and 11 women with a mean age 47+/-5 years underwent 24-h blood pressure monitoring after 8 days of placebo and after 20 days of treatment. A significant reduction (p < 0. Read More

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June 2005
3 Reads

Life-threatening renal failure caused by vasomotor nephropathy associated with nonsteroidal anti-inflammatory drugs.

Int J Clin Pharmacol Res 2004 ;24(4):117-22

Department of Medicine, 2nd Medical Faculty, Charles University, Prague, Czech Republic.

The purpose of this study was to evaluate the prevalence of life-threatening renal failure (RF) caused by vasomotor nephropathy associated with nonsteroidal anti-inflammatory drug (NSAID) treatment (NSAID-RF) and risk factors for this renal impairment in an inception cohort of patients with recently diagnosed uremia treated by emergency hemodialysis in a prospective regional study. There are few published data on this phenomenon. Two hundred fifty-six patients (137 men, 119 women, mean age 68 years [22-95 years]) with acute uremia were treated with emergency hemodialysis in the intensive care unit over a period of 70 months. Read More

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June 2005
5 Reads

Comparison of new different assay systems for thyrotropin receptor antibodies with reference to thyroid-stimulating antibodies and thyroid stimulation-blocking antibodies in Graves' disease.

Int J Clin Pharmacol Res 2004 ;24(4):111-6

Department of Laboratory Medicine, Aichi Medical University, Aichi, Aichi, Japan.

The aim of our study was to evaluate the diagnostic sensitivity of the new thyrotropin receptor antibody (TRAb) assays (Cosmic TRAb CT, ELISA and Yamasa DYNOtest TRAb). TRAb was positive in 43 of 44 (97.7%) untreated patients with Graves' disease by both TRAb CT and/or ELISA and NYNOtest TRAb. Read More

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June 2005
7 Reads

Factors influencing pain, physical function and social functioning in patients with osteoarthritis in southern Italy.

Int J Clin Pharmacol Res 2004 ;24(4):103-9

University of Messina, Messina, Italy.

The aim of this study was to assess factors influencing bodily pain (BP), physical function (PF) and social functioning (SF) in patients with osteoarthritis (OA) from southern Italy A total of 1,782 patients (mean age 66.08 years, 570 men and 1,212 women) with knee, hip, spine or hand OA underwent a structured assessment comprising demographic data and the Short Form 36 (SF-36) BP, PF and SF scales. Separate multiple linear regression models were employed for statistical analysis. Read More

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June 2005
5 Reads

Advanced glycation end product (age) inhibitors and their therapeutic implications in diseases.

Int J Clin Pharmacol Res 2004 ;24(2-3):95-101

Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.

Nonenzymatic modification of proteins by reducing sugars, a process that is also known as the Maillard reaction, leads to the formation of advanced glycation end products (AGEs) in vivo. There is a growing body of evidence that formation and accumulation of AGEs progress during normal aging, and at an extremely accelerated rate under diabetes, and are thus involved in the pathogenesis of various diseases such as diabetic vascular complications and neurodegenerative diseases. Therefore, inhibition of AGE formation may be a promising target for therapeutic intervention in AGE-related disorders. Read More

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September 2005
4 Reads

Multicenter clinical trials on a novel polyherbal formulation in allergic rhinitis.

Int J Clin Pharmacol Res 2004 ;24(2-3):79-94

ASA Foundation, New Delhi, India.

Allergic rhinitis is the most frequently occurring immunological disorder. It affects men, women and children and represents significant cost in terms of suffering and loss of productivity. Allergy is termed as an excessive reaction to an environmental allergen. Read More

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September 2005
4 Reads

Concomitant use of policosanol and beta-blockers in older patients.

Int J Clin Pharmacol Res 2004 ;24(2-3):65-77

Center for Natural Products, National Center for Scientific Research, Havana City, Cuba.

Policosanol is a cholesterol-lowering drug with concomitant antiplatelet effects. It is safe and well tolerated, even in populations with high consumption of concomitant drugs. These data suggest that adverse events (AE) due to drug-to-drug interactions (DDI) with policosanol are not relevant. Read More

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September 2005
5 Reads

Effects of d-003, a new substance purified from sugar cane wax, on platelet aggregation and plasma levels of arachidonic acid metabolites in healthy volunteers.

Int J Clin Pharmacol Res 2004 ;24(2-3):55-63

Center for Natural Products of the National Center for Scientific Research, Havana City, Cuba.

D-003 is a mixture of very high molecular weight aliphatic acids purified from sugar cane wax showing cholesterol-lowering and antiplatelet effects proven in experimental and clinical studies. Experimental evidence indicates that inhibition of platelet aggregation induced by D-003 is associated with a reduction of thromboxane B2 (TxB2) and an increase of prostacyclin (Pgl2) serum levels. This double-blinded, randomized, placebo-controlled study was undertaken to investigate whether D-003 (20 mg/day) modifies serum levels of TxB2 and Pgl2 and inhibits platelet aggregation in human healthy volunteers. Read More

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September 2005
7 Reads

Serum cystatin C as an endogenous marker of renal function in the elderly.

Int J Clin Pharmacol Res 2004 ;24(2-3):49-54

Clinical Department of Internal Medicine, Department of Nephrology, Teaching Hospital Maribor, Maribor, Slovenia.

The glomerular filtration rate (GFR) is the main indicator of kidney function. In clinical practice the GFR is often estimated from serum creatinine. In the elderly, serum creatinine is notoriously unreliable as an estimator of GFR. Read More

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September 2005
4 Reads

Clinical improvement and serum amino acid levels after mud-bath therapy.

Int J Clin Pharmacol Res 2004 ;24(2-3):39-47

Department of Rheumatology, University of Messina, Messina, Italy.

Spa therapy is an ancient approach to degenerative diseases such as osteoarthritis, but until today this tradition has been predominantly empiric and intuitive and few studies have focused on the biological changes derived from this treatment. We assessed the clinical efficacy and variations in amino acid concentrations in serum samples from patients with knee osteoarthritis who underwent spa therapy and put forward an explanation of their role in clinical improvement. Thirty-one patients with knee osteoarthritis who underwent spa therapy underwent a clinical evaluation, and serum amino acid levels were assayed before and after a cycle of balneotherapy and mud-pack therapy. Read More

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September 2005
10 Reads

Skeletal benefit after one year of risedronate therapy in patients with rheumatoid arthritis and glucocorticoid-induced osteoporosis: a prospective study.

Int J Clin Pharmacol Res 2004 ;24(2-3):33-8

Kerckhoff Clinic and Foundation, Department of Rheumatology, University Giessen, Bad Nauheim, Germany.

Glucocorticoid therapy is an important risk factor for osteoporosis in rheumatoid arthritis. Reduction in fracture risk is the most important endpoint for osteoporosis treatments. The aim of this study was to evaluate whether skeletal benefit (increases in osteosonogrammetry parameters, reduction in bone turnover and fracture incidence) are maintained during a follow-up of 1 year with risedronate therapy (5 mg/day). Read More

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September 2005
3 Reads

Analysis of job-related risks faced by hospital nurses.

Int J Clin Pharmacol Res 2004 ;24(1):27-31

Department of Medical Nursing, School of Nursing, Celal Bayar University, Manisa, Turkey.

The aim of this study was to analyze the job-related risks nurses face during training such as needle-stick injuries, contaminated blood and infectious fluids. From May to July 2003 we conducted a survey of a sample of 242 nurses who were working in the the Pediatric Hospital, Government Hospital, the Training Hospital of Celal Bayar University, the Gynecology Hospital and the Psychiatric Hospital in Manisa City in Turkey. Two hundred sixteen nurses (89. Read More

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February 2005
4 Reads

An evaluation of nursing care in cancer patients.

Int J Clin Pharmacol Res 2004 ;24(1):23-6

Department of Medical Nursing, School of Nursing, Celal Bayar University, Manisa, Turkey.

The aim of the present study was to identify what hospitalized cancer patients expect from nurses in terms of the care they receive. The specific aims of this study were: (i) to identify those individuals to whom the patients felt closest in the hospital setting and (ii) to evaluate nurses' management of cancer patients during their stay in the hospital. The sample included patients hospitalized at Ege University Hospital and Suat Seren District Hospital, Izmir, Turkey. Read More

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February 2005
5 Reads

Accelerated cardiomyopathy in maternally inherited diabetes and deafness.

Int J Clin Pharmacol Res 2004 ;24(1):15-21

Department of Internal Medicine, University of Catania School of Medicine, Catania, Italy.

The clinical features and course of cardiac involvement in a patient with maternally inherited diabetes and deafness associated with the mitochondrial DNA 3243 mutation are reported. A 45-year-old woman with maternally transmitted diabetes mellitus and deafness presented with congestive heart failure. The patient showed a short P-R interval on electrocardiogram (ECG) and had developed progression from left ventricular hypertrophy to a hypokinetic cardiomyopathy pattern over the course of 10 months. Read More

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February 2005
4 Reads

Calcipotriol in the treatment of childhood vitiligo.

Int J Clin Pharmacol Res 2004 ;24(1):11-4

Dermatology Department, Jamahiriya Hospital, Benghazi, Libya.

Eighteen patients with a clinical diagnosis of vitiligo, aged between three and 12 years (mean 8.9 years), were enrolled in this study in order to evaluate the efficacy and tolerability of topical calcipotriol in the treatment of childhood vitiligo. Six patients (33. Read More

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February 2005
4 Reads

Health-economic comparison of three recommended drugs for the treatment of osteoporosis.

Int J Clin Pharmacol Res 2004 ;24(1):1-10

InForMed - Outcomes Research and Health Economics, Ingolstadt, Germany.

Osteoporosis is a large and growing disease with significant health consequences. Based on an evaluation of clinical evidence, the German osteology umbrella organization DVO (Dachverband Osteologie deutschsprachiger wissenschaftlicher Fachgesellschaften) published guidelines in March 2003 for the diagnosis and treatment of osteoporosis. For prevention of fractures in women with postmenopausal and senile osteoporosis, these guidelines recommend three treatment options as first-line therapy: risedronate, alendronate and raloxifene. Read More

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February 2005
19 Reads

Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy.

Int J Clin Pharmacol Res 2003 ;23(4):129-34

Department of Internal Medicine III, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.

Diabetic vascular complication is a leading cause of acquired blindness, end-stage renal failure, a variety of neuropathies and accelerated atherosclerosis, which could account for disabilities and high mortality rates in patients with diabetes. Chronic hyperglycemia is essentially involved in the pathogenesis of diabetic micro- and macrovascular complications via various metabolic derangements. In this review, we discuss the molecular mechanisms of diabetic retinopathy and nephropathy, especially focusing on advanced glycation end products (AGEs) and their receptor (RAGE) system. Read More

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September 2004
9 Reads

Kineret: efficacy and safety in daily clinical practice: an interim analysis of the Kineret response assessment initiative (kreative) protocol.

Int J Clin Pharmacol Res 2003 ;23(4):119-28

Evangelical Hospital, Düsseldorf, Germany.

Data from 166 patients who had completed 6 months of anakinra (Kineret, r-metHuIL-1Ra) therapy under the conditions of daily clinical practice showed an efficacy and safety profile comparable to the data known from clinical trials. Patients significantly responded as early as 1 month following initiation of therapy. The data suggest that anakinra may also be effective in patients who have failed tumor necrosis factor (TNF)-blocking agents. Read More

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September 2004
5 Reads

The acute effect of orlistat on endothelial function in young obese women.

Int J Clin Pharmacol Res 2003 ;23(4):111-7

Department of Cardiology, Celal Bayar University, School of Medicine, Manisa, Turkey.

Recent studies indicate that abdominal fat accumulation is related to impaired endothelial function in young healthy volunteers. The aim of this study was to determine the acute effect of gastrointestinal lipase inhibitor on brachial flow-mediated vasodilatation and hemodynamic parameters in young obese women. The study population was composed of 42 female obese patients (mean age 29 +/- 4 years, age range between 18 and 34 years). Read More

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September 2004
4 Reads

Effect of raloxifene on lowering lipid parameters in patients with osteoporosis.

Int J Clin Pharmacol Res 2003 ;23(4):107-10

Department of Internal Medicine, General Hospital Dr. Josip Bencevic, Andrije Stampara 42, 35000 Slavonski Brod, Croatia.

The aim of this study was to show the effect of raloxifene on the lowering of lipid parameters in patients with osteoporosis. New investigations introduced selective estrogen receptor modulators (SERMs), such as raloxifene, as a potent drug in the lowering of lipid parameters. Raloxifene is known as a substance that works well in preventing and treating osteoporosis. Read More

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September 2004
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Pharmacoeconomic analysis of osteoporosis treatment with risedronate.

Int J Clin Pharmacol Res 2003 ;23(4):93-105

InForMed GmbH-Outcomes Research and Health Economics, Schwanthaler Str. 28, 85049 Ingolstadt, Germany.

Hip fracture is an important and costly problem. Therapy with the bisphosphonate risedronate effectively prevents hip and other fractures among women with established osteoporosis. Risedronate is a first-choice therapy option in the German Guidelines of the Dachverband Osteologie for Osteoporosis according to evidence-based medicine criteria for the treatment of postmenopausal osteoporosis, osteoporosis of the elderly (women aged > 75 years) and glucocorticoid-induced osteoporosis. Read More

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September 2004
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Salmeterol decreases eosinophilic cationic protein and rescue medication in patients inhaling beclomethasone dipropionate: preliminary study in mild and moderate asthma in Trinidad, West Indies.

Int J Clin Pharmacol Res 2003 ;23(2-3):69-74

Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, Trinidad, West Indies.

Activated eosinophils play a critical role in asthma pathogenesis, and eosinophil cationic protein (ECP) is a useful indicator of inflammation. Inhaled corticosteroids and long-acting beta2-agonists (LABA) effectively control asthma symptoms and improve airway function. Salmeterol's anti-inflammatory efficacy as add-on therapy to inhaled corticosteroids has not been evaluated in Caribbean populations. Read More

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April 2004
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Eggshell calcium in the prevention and treatment of osteoporosis.

Int J Clin Pharmacol Res 2003 ;23(2-3):83-92

National Institute of Rheumatic Diseases, Piestany, Slovak Republic.

In this paper the most significant biological and clinical aspects of a biopreparation made of chicken eggshells are reviewed. Eggshell powder is a natural source of calcium and other elements (e.g. Read More

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April 2004
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Interindividual variation in the ratio between plasma morphine and its metabolites in cancer patients.

Int J Clin Pharmacol Res 2003 ;23(2-3):75-82

Department of Hospital Pharmacy, National Fukuokahigashi Hospital, Koga, Japan.

In 25 cancer patients treated with slow-release oral morphine and in 10 cancer patients treated with continuous infusion of morphine, plasma steady-state concentrations of morphine (M), morphine-3-glucuronide (M-3-G) and morphine-6-glucuronide (M-6-G) were determined by high-performance liquid chromatography. Blood samples were withdrawn at 0, 2 and 6 h after oral administration in patients treated with slow-release oral morphine and once or twice a day in patients treated with continuous infusion of morphine. In four cancer patients treated with continuous infusion of morphine, in order to analyze chronopharmacokinetic variability, the M-3-G/M ratio was observed at 12:00 h and 24:00 h. Read More

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April 2004
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