10 results match your criteria International Journal of Clinical Medicine [Journal]

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Macrophage TGF-1 and the Proapoptotic Extracellular Matrix Protein BIGH3 Induce Renal Cell Apoptosis in Prediabetic and Diabetic Conditions.

Int J Clin Med 2016 Jul 21;7(7):496-510. Epub 2016 Jul 21.

Departments of Biochemistry and Clinical Laboratory Sciences, School of Health Professions, University of Texas Health Science Center at San Antonio, San Antonio, USA.

Metabolically stressed kidney is in part characterized by infiltrating macrophages and macrophage-derived TGF-1 that promote the synthesis of various ECM molecules. TGF-1 strongly enhances the expression of the gene that encodes a cell-adhesion class, proapoptotic ECM protein called BIGH3. We hypothesized that in a diabetic environment a relationship between infiltrating macrophages, macrophage-derived TGF-1, and BIGH3 protein promotes renal cell death. Read More

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http://dx.doi.org/10.4236/ijcm.2016.77055DOI Listing
July 2016
16 Reads

Impact of Maintenance Steroids versus Rapid Steroid Withdrawal in African-American Kidney Transplant Recipients: Comparison of Two Urban Centers.

Int J Clin Med 2016;7:204-216

Department of Medicine, Division of Nephrology, Loyola University Medical Center, Maywood, IL, USA.

Background: Rapid steroid withdrawal (RSW) is used increasingly in kidney transplantation but long-term outcomes in African-American (AA) recipients are not well known. We compared 1 and 5 year transplant outcomes in a large cohort of AA patients who were maintained on continued steroid therapy (CST) to those who underwent RSW.

Methods: Post-transplant courses of A as receiving kidney allografts from 2003-2011 at two urban transplant centers in Chicago were followed. Read More

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http://dx.doi.org/10.4236/ijcm.2016.73021DOI Listing
January 2016
29 Reads

Differential Measurements of Oxidatively Modified Proteins in Colorectal Adenopolyps.

Int J Clin Med 2015 Apr;6(4):288-299

Department of Medicine, Morehouse School of Medicine, Atlanta, USA.

Introduction: Adenopolyps patients have a three-fold higher risk of colon cancer over the general population, which increases to six-fold if the polyps are multiple and with lower survival among African American population. Currently, 6% of CRC can be ascribed to mutations in particular genes. Moreover, the optimal management of patients with colorectal adenopolyps depends on the accuracy of appropriate staging strategies because patients with similar colorectal adenocarcinoma architecture display heterogeneity in the course and outcome of the disease. Read More

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http://dx.doi.org/10.4236/ijcm.2015.64037DOI Listing
April 2015
11 Reads

Novel Synergistic Protective Efficacy of Atovaquone and Diclazuril on Fetal-Maternal Toxoplasmosis.

Helieh S Oz

Int J Clin Med 2014 Aug;5(15):921-932

Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY, USA

Over 1 billion people globally are estimated to be infected with with severe or unknown consequences and no safe and effective therapies are available against congenital or persistent chronic infection. We propose that atovaquone and diclazuril synergistically protect against fetal-maternal toxoplasmosis.

Methods: Programmed pregnant mice were treated with atovaquone and diclazuril monotherapy, or combined (atovaquone + diclazuril) therapy and infected with tachyzoites (0, 300, 600) and the course of infection was studied. Read More

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August 2014
4 Reads

Survey of -Specific Infection Control Policies in Local Long-Term Care Facilities.

Int J Clin Med 2014 Apr;5(7):414-419

Department of Internal Medicine, Division of General Medicine, Geriatrics, and Palliative Care, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, USA.

Introduction: The incidence and severity of infection (CDI) has been increasing and long-term care facility (LTCF) residents are at high risk given their age, co-morbidities, and high antibiotic exposure. Infection control policies are crucial for controlling CDI, but there are currently no regulatory guidelines in the United States. Therefore, we evaluated infection control policies in local LTCFs to define the CDI-specific policies and the administrative and staff understanding of CDI, so as to identify perceived barriers for compliance. Read More

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http://dx.doi.org/10.4236/ijcm.2014.57056DOI Listing
April 2014
7 Reads

Diclazuril Protects against Maternal Gastrointestinal Syndrome and Congenital Toxoplasmosis.

Int J Clin Med 2014 Jan;5(3):93-101

The Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, College of Agriculture, University of Kentucky, Lexington, USA.

Background: Toxoplasmosis is a common cause of foodborne, gastrointestinal and congenital syndrome with particularly severe or unknown health consequences. There is no safe and effective preventive or therapeutic modality against congenital toxoplasmosis or to eliminate the persistent chronic infection.

Hypothesis: Diclazuril to be safe in pregnancy and effective against gastrointestinal toxoplasmosis. Read More

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http://dx.doi.org/10.4236/ijcm.2014.53017DOI Listing
January 2014
4 Reads

Hereditary leukemia due to rare RUNX1c splice variant (L472X) presents with eczematous phenotype.

Int J Clin Med 2012 Dec;3(7)

Division of Hematology and Transplantation, City Hope National Medical Center, Duarte, CA.

Deleterious mutations in the gene cause hereditary leukemia due to a rare syndrome called Familial platelet Disorder with Associated Myeloid Malignancy (FPDMM). We describe the characteristics of a family with FPDMM due to a novel RUNX1 mutation (L472X), located in the most 3-prime end of the gene reported to date. Our 36-year old proband presented with incidentally detected thrombocytopenia and a family history suggestive of FPDMM. Read More

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http://dx.doi.org/10.4236/ijcm.2012.37110DOI Listing
December 2012
3 Reads

The Aging Waistline: Impact of the Geriatric Obesity Epidemic on an Urban Emergency Department: Original Communication.

Int J Clin Med 2013 May;4(5):268-272

Department of Emergency Medicine, University of Illinois, Chicago, USA.

Purpose: Reviews adult emergency department (ED) visits for patients age 65 and older during one calendar year; determine the prevalence of weight classifications; identifies trends between BMI and discharge/admitting diagnoses, vital signs, and severity index.

Methods: The electronic medical records system and data from the ED billing service was reviewed for an urban academic institution with an annual volume of 125,000 for patients age > 65. Using a random number table, a retrospective cohort of 328 elderly patients was selected for review, representing a convenience sample of 2. Read More

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http://dx.doi.org/10.4236/ijcm.2013.45047DOI Listing
May 2013
42 Reads

Angiotensinogen Expression Is Enhanced in the Progression of Glomerular Disease.

Int J Clin Med 2011 Sep;2(1):378-387

Department of Physiology, and Hypertension and Renal Center of Excellence Tulane University Health Sciences Center, New Orleans, USA.

Intrarenal renin-angiotensin system (RAS) activation plays a critical role in the development and progression of renal injury. In the kidney, all of the RAS components are present and intrarenal angiotensin II (Ang II) is formed by multiple independent mechanisms. Angiotensinogen (AGT) is the only known substrate for renin that is a rate-limiting enzyme of the RAS. Read More

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http://dx.doi.org/10.4236/ijcm.2011.24064DOI Listing
September 2011
5 Reads

Increased Apoptosis in Chorionic Trophoblasts of Human Fetal Membranes with Labor at Term.

Int J Clin Med 2012 ;3(2):136-142

Department of Obstetrics & Gynecology, University of Texas Medical Branch, Galveston, Texas.

Objective: To determine the association of apoptosis in the layers of human fetal membranes with labor at term.

Study Design: Human fetal membranes were collected from elective cesarean sections (n = 8) and spontaneous vaginal deliveries (n = 8) at term. The extent of apoptosis within the layers of fetal membranes was determined using terminal deoxynucleotidyl transferase deoxy-UTP-nick end labeling (TUNEL) immunohistochemical assay and western blots. Read More

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http://dx.doi.org/10.4236/ijcm.2012.32027DOI Listing
January 2012
12 Reads
1 Citation
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