1,586 results match your criteria International Journal of Biological Markers[Journal]


New and old biomarkers in the differential diagnosis of lung cancer: Pro-gastrin-releasing peptide in comparison with neuron-specific enolase, carcinoembryonic antigen, and CYFRA 21-1.

Int J Biol Markers 2019 Apr 17:1724600819834235. Epub 2019 Apr 17.

5 Division of Laboratory Medicine, Humanitas Clinical and Research Center, IRCCS, Rozzano Milan, Italy.

Background: Testing for circulating biomarkers in lung cancer is hampered by the insufficient specificity. We aimed to assess the relative diagnostic accuracy of pro-gastrin-releasing peptide (ProGRP) for the differential diagnosis of small cell lung cancer and compare it with more conventional biomarkers.

Methods: We enrolled a cohort of 390 patients with a clinical suspicion of lung cancer and for whom a histologic assessment was available. Read More

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http://dx.doi.org/10.1177/1724600819834235DOI Listing

Prognostic markers affecting the early recurrence of hepatocellular carcinoma with liver cirrhosis after curative resection.

Int J Biol Markers 2019 Apr 12:1724600819834306. Epub 2019 Apr 12.

1 Division of Hepato-Biliary-Pancreas Surgery, Department of Surgery, Korea University Guro Hospital, Korea University Medical College, Seoul, Korea.

Background: Early recurrence is associated with poor prognosis after curative resection for hepatocellular carcinoma. Thus, we studied which factors, including this inflammation-based scoring system, affect disease recurrence in single hepatocellular carcinoma patients with liver cirrhosis.

Methods: A total of 430 consecutive hepatocellular carcinoma patients were enrolled in our institution between January 2002 and December 2015. Read More

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http://dx.doi.org/10.1177/1724600819834306DOI Listing
April 2019
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Cell-free microRNAs as non-invasive biomarkers in glioma: a diagnostic meta-analysis.

Int J Biol Markers 2019 Apr 10:1724600819840033. Epub 2019 Apr 10.

3 Cancer Center, Linyi People's Hospital, Shandong University, Linyi, Shandong Province, China.

Objective: Since the diagnostic value of microRNAs for detecting glioma is contentious, we aimed to carry out a meta-analysis to synthetically evaluate the diagnostic significance of cell-free microRNAs in cerebrospinal fluid and blood in the detection of glioma.

Methods: A systematic document retrieval of public databases was performed to obtain eligible studies. Specificity was applied to draw the summary receiver operator characteristic (SROC) curve against sensitivity, and the pooled diagnostic efficiency was assessed by generating the area under the SROC curve. Read More

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http://dx.doi.org/10.1177/1724600819840033DOI Listing
April 2019
2 Reads

Cancer registries - guardians of breast cancer biomarker information: A systematic review.

Int J Biol Markers 2019 Apr 10:1724600819836097. Epub 2019 Apr 10.

European Commission, Joint Research Centre (JRC), Ispra, Italy.

Background: Breast cancer is the most common cancer and the leading cause of cancer-related death in females, with a large societal and economic impact. Decisions regarding its treatment are largely affected by the categorization into different subtypes with hormone receptor status and HER2 status being the most important predictive factors. Other biological markers play an important role for prognostic and predictive reasons. Read More

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http://dx.doi.org/10.1177/1724600819836097DOI Listing
April 2019
1 Read

Association of STMN1 with survival in solid tumors: A systematic review and meta-analysis.

Int J Biol Markers 2019 Apr 9:1724600819837210. Epub 2019 Apr 9.

1 Department of General Surgery, Lanzhou University Second Clinical Medical College, Lanzhou University, Lanzhou, China.

Background: The prognostic value of Stathmin 1 (STMN1) in malignant solid tumors remains controversial. Thus, we conducted this meta-analysis to summarize the potential value of STMN1 as a biomarker for predicting overall survival in patients with solid tumor.

Methods: We systematically searched eligible studies in PubMed, Web of Science, and EMBASE from the establishment date of these databases to September 2018. Read More

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http://dx.doi.org/10.1177/1724600819837210DOI Listing
April 2019
1 Read

Preoperative serum high-density lipoprotein cholesterol as a predictor of poor survival in patients with clear cell renal cell cancer.

Int J Biol Markers 2019 Mar 26:1724600819831404. Epub 2019 Mar 26.

4 Department of Urology, the Third Affiliated Hospital of Soochow University, Changzhou, China.

Purpose:: Numerous studies have suggested that dyslipidemia is closely related to various cancers and the high-density lipoprotein cholesterol (HDL-C) levels are associated with the outcome of cancer patients. However, the predictive value of HDL-C in patients with renal cell carcinoma remains unclear. Our study aims to explore the relationship between the levels of serum HDL-C and the prognosis of renal cell carcinoma. Read More

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http://dx.doi.org/10.1177/1724600819831404DOI Listing
March 2019
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Baseline hemoglobin <11.0 g/dL has stronger prognostic value than anemia status in nasopharynx cancers treated with chemoradiotherapy.

Int J Biol Markers 2019 Mar 13:1724600818821688. Epub 2019 Mar 13.

5 Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey.

Background:: To retrospectively investigate the influence of pretreatment anemia and hemoglobin levels on the survival of nasopharyngeal carcinoma patients treated with concurrent chemoradiotherapy (C-CRT).

Methods:: A total of 149 nasopharyngeal carcinoma patients who received C-CRT were included. All patients had received 70 Gy to the primary tumor plus the involved lymph nodes, and 59. Read More

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http://dx.doi.org/10.1177/1724600818821688DOI Listing
March 2019
1 Read
1.360 Impact Factor

Urinary exosomal shuttle RNA: Promising cancer diagnosis biomarkers of lower urinary tract.

Int J Biol Markers 2019 Mar 13:1724600819827023. Epub 2019 Mar 13.

1 Institutional BioBank, Experimental Oncology and Biobank Management Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italia.

Background:: Prostate and bladder cancers continue to be the first and fourth most common cancers in men worldwide; thus there is an urgent need for more accurate biomarkers that can detect these types of cancer in a non-invasive way. Liquid biopsy is a new non-invasive tool for diagnosis and with a virtually unlimited supply urine is even more attractive resource since urinary exosomes have been discovered to contain RNAs that are hallmarks of cancer. It is challenging to assay those secreting lower amounts of molecules. Read More

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http://dx.doi.org/10.1177/1724600819827023DOI Listing

Clinicopathological and molecular differences in colorectal cancer according to location.

Int J Biol Markers 2019 Mar 10:1724600818807164. Epub 2019 Mar 10.

1 Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.

Purpose:: The incidence, pathogenesis, molecular pathways, and outcomes of colorectal cancer vary depending on the location of the tumor. This study aimed to compare the difference in tumor characteristics and the outcome between right-sided colon cancer and left-sided colorectal cancer (LCRC).

Materials And Methods:: A total of 1503 patients with colorectal cancer who underwent surgery at the Taipei Veterans General Hospital between 2000 and 2010 were enrolled in this study. Read More

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http://dx.doi.org/10.1177/1724600818807164DOI Listing
March 2019
3 Reads

Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial.

Int J Biol Markers 2019 Mar 10:1724600818803104. Epub 2019 Mar 10.

4 Department of Medicine (Hematology & Oncology), Wake Forest School of Medicine, Winston-Salem, NC, USA.

Purpose/objectives:: We aimed to assess the predictive value of a lung cancer gene panel for the development of brain metastases.

Materials/methods:: Between 2011 and 2015, 102 patients with lung cancer were prospectively enrolled in a clinical trial in which a diagnostic fine-needle aspirate was obtained. Gene expression was conducted on all samples that rendered a diagnosis of non-small cell lung cancer (NSCLC). Read More

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http://dx.doi.org/10.1177/1724600818803104DOI Listing
March 2019
1 Read

Prognostic roles of microRNA 143 and microRNA 145 in colorectal cancer: A meta-analysis.

Int J Biol Markers 2019 Mar 10:1724600818807492. Epub 2019 Mar 10.

Department of Colorectal and Anal Surgery, The First Hospital of Jilin University, Jilin, P.R. China.

Background:: A systematic analysis was conducted to clarify the relationship between miR-143/145 and the prognosis of colorectal cancer.

Materials And Methods:: We searched four databases: PubMed, EMBASE, Web of Science, and the Cochrane Library. We extracted and estimated the hazard ratios for survival outcomes, which compared low and high expression levels of miR-143/145 in colorectal cancer patients in the available studies. Read More

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http://dx.doi.org/10.1177/1724600818807492DOI Listing
March 2019
2 Reads
1.360 Impact Factor

Associated measurement of fucosylated levels of AFP, DCP, and GPC3 for early diagnosis in hepatocellular carcinoma.

Int J Biol Markers 2019 Mar 10:1724600818812472. Epub 2019 Mar 10.

1 Department of General Surgery, Beijing YouAn Hospital, Capital Medical University, Beijing, China.

Background:: Hepatocellular carcinoma is a serious health problem worldwide, especially in Asian countries, such as China. However, there are difficulties in diagnosing and treating hepatocellular carcinoma. The alteration of fucosylated proteins was closely associated with carcinogenesis. Read More

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http://dx.doi.org/10.1177/1724600818812472DOI Listing
March 2019
8 Reads

β-Arrestin-1 expression and epithelial-to-mesenchymal transition in laryngeal carcinoma.

Int J Biol Markers 2019 Mar 10:1724600818813621. Epub 2019 Mar 10.

2 Department of Medicine DIMED, University of Padova, Italy.

Aim:: The novel primary end-point of the present study was to ascertain β-arrestin-1 expression in a cohort of consecutive patients with laryngeal squamous cell carcinoma (LSCC) with information available on their cigarette-smoking habits. A secondary end-point was to conduct a preliminary clinical and pathological investigation into the possible role of β-arrestin-1 in the epithelial-to-mesenchymal transition (EMT), identified by testing for E-cadherin, Zeb1, and Zeb2 expression, in the setting of LSCC.

Methods:: The expression of β-arrestin-1, E-cadherin, zeb1, and zeb2 was ascertained in 20 consecutive LSCCs. Read More

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http://dx.doi.org/10.1177/1724600818813621DOI Listing
March 2019
1.360 Impact Factor

Clinicopathological and prognostic significance of metastasis-associated in colon cancer-1 in gastric cancer: A meta-analysis.

Int J Biol Markers 2019 Mar 10:1724600818813634. Epub 2019 Mar 10.

1 Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, P.R. China.

Background:: The gene metastasis-associated in colon cancer-1 (MACC1) has been reported to be overexpressed in diverse human malignancies, and an increasing amount of evidence suggests that its overexpression is associated with the development and progression of many human tumors. However, the prognostic and clinicopathological value of MACC1 in gastric cancer remains inconclusive. Therefore, we conducted this meta-analysis to investigate the effect of positive MACC1 expression on clinicopathological features and survival outcomes in gastric cancer. Read More

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http://dx.doi.org/10.1177/1724600818813634DOI Listing
March 2019
1 Read

Correlation between PNPLA3 rs738409 polymorphism and hepatocellular carcinoma: a meta-analysis of 10,330 subjects.

Int J Biol Markers 2019 Mar 11:1724600818812471. Epub 2019 Mar 11.

Department of Gastroenterology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Purpose:: The correlation between patatin-like phospholipase domain-containing protein 3 ( PNPLA3) rs738409 polymorphism and hepatocellular carcinoma was investigated by several pilot studies, but the results of these studies were controversial. Therefore, we performed this study to better assess the relationship between PNPLA3 rs738409 polymorphism and the likelihood of hepatocellular carcinoma.

Methods:: Eligible studies were searched in PubMed, Medline, EMBASE, and Web of Science. Read More

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http://dx.doi.org/10.1177/1724600818812471DOI Listing
March 2019
1 Read

MicroRNA-373 promotes the development of esophageal squamous cell carcinoma by targeting LATS2 and OXR1.

Int J Biol Markers 2019 Mar 11:1724600819827964. Epub 2019 Mar 11.

College of Life Science, Henan Normal University, Xinxiang, Henan, P.R. China.

Introduction:: MicroRNA373 was highly expressed in many tumors including esophageal cancer. However, its molecular mechanism is still unclear, especially epigenetic modification, in esophageal squamous cell carcinoma (ESCC).

Methods:: In this study, we investigated serum levels of the miR-371-373 cluster in ESCC patients before and after surgical removal, and further focused on the expression level of miR-373-3p in tumor tissues of ESCC patients and its target genes. Read More

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http://dx.doi.org/10.1177/1724600819827964DOI Listing
March 2019
1 Read
1.360 Impact Factor

Molecular basis of familial adenomatous polyposis in the southeast of Brazil: identification of six novel mutations.

Int J Biol Markers 2019 Mar 11:1724600818814462. Epub 2019 Mar 11.

1 Departament of Genetics, Ribeirão Preto Medical School, University of São Paulo, Brazil.

Background:: The goal of this study was to screen point mutations and deletions in APC and MUTYH genes in patients suspected of familial adenomatous polyposis (FAP) in a Brazilian cohort.

Methods:: We used high-resolution melting, Sanger direct sequencing and multiplex ligation-dependent probe association (MLPA) assays to identify point mutations, and large genomic variations within the coding regions of APC and MUTYH genes.

Results:: We identified 19 causative mutations in 40 Brazilian patients from 20 different families. Read More

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http://dx.doi.org/10.1177/1724600818814462DOI Listing

Expression of long intergenic non-coding RNA, regulator of reprogramming, and its prognostic value in patients with glioblastoma.

Int J Biol Markers 2019 Mar 11:1724600818814459. Epub 2019 Mar 11.

2 Center of Excellence in Molecular and Cellular Medicine, FOM/SCU, Ismailia, Egypt.

Background:: Long intergenic non-coding RNA, regulator of reprogramming ( LINC-ROR) is a newly identified cytoplasmic long non-coding RNA (lncRNA), which has been found to be dysregulated in different cancers. The present work aimed to quantify LINC-ROR expression profile and assess the tumor proteins p53 and caspase 3 expressions in glioblastoma tissue specimens compared to non-cancer tissues, and to correlate these expression levels with the available clinicopathological and survival data.

Methods:: LINC-ROR relative expression in 57 glioblastoma cancer tissues and 10 non-cancer tissues was quantified by real-time polymerase chain reaction (qPCR). Read More

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http://dx.doi.org/10.1177/1724600818814459DOI Listing
March 2019
1.360 Impact Factor

Prognostic nomogram for patients with non-metastatic HER2 positive breast cancer in a prospective cohort.

Int J Biol Markers 2019 Mar 11:1724600818824786. Epub 2019 Mar 11.

1 Laboratory of Molecular Diagnosis of Cancer & Breast Medical Oncology, Clinical Research Center for Breast, West China Hospital, Sichuan University, Chengdu, China.

Purpose:: A nomogram is a reliable tool to generate individualized risk prediction by combining prognostic factors. We aimed to construct a nomogram for predicting the survival in patients with non-metastatic human epidermal growth factor receptor 2 (HER2) positive breast cancer in a prospective cohort.

Methods:: We analyzed 1304 consecutive patients who were diagnosed with non-metastatic HER2 positive breast cancer between January 2008 and December 2016 in our institution. Read More

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http://dx.doi.org/10.1177/1724600818824786DOI Listing
March 2019
1 Read

Elevated neutrophil to lymphocyte and platelet to lymphocyte ratios predict high grade and advanced stage renal cell carcinoma.

Int J Biol Markers 2019 Mar 11:1724600818817557. Epub 2019 Mar 11.

Department of Urology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey.

Introduction:: Renal cell carcinoma is the most common malignancy of the kidney, which accounts 85% of all renal tumors. In recent years, the incidence of renal cell carcinoma was increased due to the widespread use of imaging techniques. The aim of this study is to investigate the clinical significance of pretreatment neutrophil to lymphocyte and platelet to lymphocyte ratios in patients with renal cell carcinomas. Read More

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http://dx.doi.org/10.1177/1724600818817557DOI Listing
March 2019
1 Read

Serum carcinoembryonic antigen to predict recurrence in the follow-up of patients with colorectal cancer.

Int J Biol Markers 2019 Mar 11:1724600818820679. Epub 2019 Mar 11.

1 Department of Surgery Amphia Hospital Breda, the Netherlands.

Introduction:: Serum carcinoembryonic (CEA) antigen is used as a diagnostic screening tool during follow-up in colorectal cancer patients. However, it remains unclear whether preoperative serum CEA is a reliable marker in the follow-up to predict recurrence. The aim of the study is to determine the value of elevated pre- and postoperative serum carcinoembryonic antigen levels (CEA > 5 µg/L) as an independent prognostic factor for locoregional and distant recurrence in patients who underwent curative surgery for colorectal cancer. Read More

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http://dx.doi.org/10.1177/1724600818820679DOI Listing

Performance of a MethyLight assay for methylated SFRP2 DNA detection in colorectal cancer tissue and serum.

Int J Biol Markers 2019 Mar 11:1724600818820536. Epub 2019 Mar 11.

1 Department of Gastroenterology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Jiangsu, China.

Background:: Colorectal cancer is one of the five most common cancers in China, and its incidence is steadily increasing. An accurate and non-invasive screening method is needed to increase the population uptake of colorectal cancer screening. Secreted frizzled-related protein 2 ( SFRP2) has been found to be hypermethylated in most colorectal cancer patients, and it may fulfill the role of a non-invasive biomarker for colorectal cancer screening. Read More

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http://dx.doi.org/10.1177/1724600818820536DOI Listing
March 2019
2 Reads

Clinicopathological significance and prognostic role of tumor-infiltrating lymphocytes in colorectal cancer.

Int J Biol Markers 2019 Mar 11:1724600818817320. Epub 2019 Mar 11.

2 Department of Pathology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Republic of Korea.

Purpose:: This study aimed to elucidate the clinicopathological significance and prognostic role of tumor-infiltrating lymphocytes in colorectal cancer.

Methods:: The immunohistochemistry of CD3 and CD8 was performed on 265 human colorectal cancer tissues to investigate the tumor-infiltrating lymphocytes using Immunoscore. The correlation between Immunoscore and clinicopathological characteristics, including survival rates, was elucidated. Read More

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http://dx.doi.org/10.1177/1724600818817320DOI Listing
March 2019
1 Read
1.360 Impact Factor

The metabolomic scent of cancer disease progression in soft tissue sarcoma: A case report.

Int J Biol Markers 2019 Mar 11:1724600818817316. Epub 2019 Mar 11.

5 Immunopathology and Cancer Biomarkers Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.

Background:: The purpose of this case report is to describe the potential that metabolomics breath analysis may have in cancer disease monitoring. The advances in mass spectrometry instrumentation allow the accurate real-time analysis of volatile metabolites exhaled in the breath. The application of such non-invasive devices may provide innovative and complementary monitoring of the physio-pathological conditions of cancer patients. Read More

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http://dx.doi.org/10.1177/1724600818817316DOI Listing
March 2019
1 Read
1.360 Impact Factor

Precision medicine in the ageing world: The role of biospecimen sciences.

Int J Biol Markers 2019 Mar 11:1724600818816995. Epub 2019 Mar 11.

1 Interinstitutional Multidisciplinary Biobank (BioBIM), IRCCS San Raffaele Pisana, Rome, Italy.

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http://dx.doi.org/10.1177/1724600818816995DOI Listing

The challenge of the reference intervals determination: An example from two articles published in the present issue.

Authors:
Ruggero Dittadi

Int J Biol Markers 2018 Nov;33(4):553-554

UOC Laboratory Medicine, Ospedale dellAngelo, Mestre, Italy.

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http://dx.doi.org/10.1177/1724600818817561DOI Listing
November 2018

Prognostic value of pretreatment prognostic nutritional index in non-small cell lung cancer: A systematic review and meta-analysis.

Int J Biol Markers 2018 Nov 3;33(4):372-378. Epub 2018 Oct 3.

1 Department of Endocrinology and Metabolism, Shenzhen Nanshan People's Hospital, ShenZhen, China.

Background:: The pretreatment prognostic nutritional index has been considered a potential prognostic biomarker in patients with non-small cell lung cancer (NSCLC), but this remains controversial. Therefore, we performed a meta-analysis to systematically assess the prognostic value of the prognostic nutritional index in patients with NSCLC.

Methods:: We systematically searched PubMed, EMBASE, Web of Science, and CNKI. Read More

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http://journals.sagepub.com/doi/10.1177/1724600818799876
Publisher Site
http://dx.doi.org/10.1177/1724600818799876DOI Listing
November 2018
4 Reads

Clinical significance of fucosylated GP73 in the differential diagnosis of hepatocellular carcinoma.

Int J Biol Markers 2018 Nov 21;33(4):439-446. Epub 2018 Sep 21.

1 Department of Clinical Laboratory, The First Hospital of Qinhuangdao, Qinhuangdao, China.

Objective:: To investigate the clinical value of fucosylated GP73 (Fuc-GP73) levels for differential diagnosis of hepatocellular carcinoma from other liver diseases.

Methods:: Serum specimens were collected from 50 patients with hepatocellular carcinoma, 60 patients with other digestive system diseases (ODSD), and 40 normal controls. Lectin affinity chromatography column combining with the enzyme-linked immunosorbent assay (ELISA) using the ELISA index was utilized to measure the level of Fuc-GP73. Read More

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http://dx.doi.org/10.1177/1724600818796646DOI Listing
November 2018
2 Reads

Relationship between GSTP1 rs1695 gene polymorphism and myelosuppression induced by platinum-based drugs: a meta-analysis.

Int J Biol Markers 2018 Sep 21:1724600818792897. Epub 2018 Sep 21.

3 First Department of Cancer Research Institute, the First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China.

Although many previous studies have reported the relationship between GSTP1 rs1695 gene polymorphism and myelosuppression induced by platinum-based drugs, the conclusions are not consistent. The aim of the study is to evaluate the association between granulocytopenia and thrombocytopenia induced by platinum-based drugs and GSTP1 rs1695 gene polymorphism by meta-analysis. A literature search was performed using the Pubmed, Embase, CNKI, and Wanfang databases, and the odds ratio (OR) and its 95% confidence interval (CI) were used to evaluate the correlation. Read More

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http://dx.doi.org/10.1177/1724600818792897DOI Listing
September 2018
24 Reads

Diagnostic and prognostic value of HE4 in female patients with primary peritoneal carcinoma.

Int J Biol Markers 2018 Sep 21:1724600818796595. Epub 2018 Sep 21.

Department of Clinical Laboratory, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, China.

Background: HE4 is a useful tumor marker for the diagnosis of ovarian, endometrial, and fallopian tube carcinoma.

Aim: The aim of our study was to investigate the value of serum HE4 compared with CA125 in the diagnosis of primary peritoneal carcinoma and the estimation of treatment response and recurrence.

Methods: Serum HE4 and CA125 concentrations were measured in both primary peritoneal carcinoma patients and benign gynecological disease controls. Read More

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http://journals.sagepub.com/doi/10.1177/1724600818796595
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http://dx.doi.org/10.1177/1724600818796595DOI Listing
September 2018
15 Reads

Carcinosarcoma of the prostate: case report with molecular and histological characterization.

Int J Biol Markers 2018 Nov 12;33(4):540-544. Epub 2018 Aug 12.

4 Pathology Unit, Morgagni Pierantoni Hospital, Forlì, Italy.

Background:: We report a case of prostatic carcinosarcoma, a rare variant of prostatic cancer, which is composed of a mixture of epithelial and mesenchymal components with a generally poor outcome.

Aims And Methods:: We aim to identify molecular alterations, in particular copy number variations of AR and c -MYC genes, methylation and expression of glutathione S-transferase P1 (GSTP1), programmed death-ligand 1 (PD-L1), AR, and phosphorylated AR expression.

Results:: We found a distinct molecular pattern between adenocarcinoma and carcinosarcoma, which was characterized by high AR copy number variation gain; positive expression of PD-L1, AR, and phosphorylated AR; low espression of GSTP1 in epithelial component. Read More

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http://dx.doi.org/10.1177/1724600818791463DOI Listing
November 2018
11 Reads

Diagnosis accuracy of serum glypican-3 level in patients with hepatocellular carcinoma: a systematic review with meta-analysis.

Int J Biol Markers 2018 Aug 2:1724600818784409. Epub 2018 Aug 2.

1 Department of Hepatobiliary Surgery, YouAn Hospital Affiliated to Capital Medical University, Beijing, China.

Background: Previous studies have evaluated the diagnostic value of serum glypican-3 in patients with hepatocellular carcinoma. However, the results remain inconsistent and even controversial. Thus, the aim of the present meta-analysis was to clarify the diagnostic accuracy of serum glypican-3 for hepatocellular carcinoma. Read More

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http://dx.doi.org/10.1177/1724600818784409DOI Listing
August 2018
3 Reads

Decreased apolipoprotein A4 and increased complement component 3 as potential markers for papillary thyroid carcinoma: A proteomic study.

Int J Biol Markers 2018 Nov 30;33(4):455-462. Epub 2018 Jul 30.

4 Department of Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background:: Thyroid carcinomas have comprised the fastest rising incidence of cancer in the past decade. Currently, the diagnosis of thyroid tumors is performed by the fine-needle aspiration biopsy (FNAB) method, which still holds some challenges and limitations, mostly in discriminating malignant and benign lesions. Therefore, the development of molecular markers to distinguish between these lesion types are in progress. Read More

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http://dx.doi.org/10.1177/1724600818787752DOI Listing
November 2018
4 Reads
1.360 Impact Factor

Stability of total prostate-specific antigen and free prostate-specific antigen after 10 years' storage.

Int J Biol Markers 2018 Jul 27:1724600818789414. Epub 2018 Jul 27.

1 Department of Immunochemistry, University Hospital and Faculty of Medicine in Pilsen, Czech Republic.

Introduction: PSA is a serine protease composed of 240 amino acids in a single polypeptide chain and is a routine parameter in prostate cancer diagnostics. The aim of our study was to test the long-term stability of tPSA and fPSA after 10 years' storage at -80°C.

Materials And Methods: We analyzed two aliquots from 55 serum samples. Read More

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http://dx.doi.org/10.1177/1724600818789414DOI Listing
July 2018
4 Reads

Association between an insertion/deletion polymorphism in the interleukin-1α gene and the risk of colorectal cancer in a Chinese population.

Int J Biol Markers 2018 Jul 1:1724600818785069. Epub 2018 Jul 1.

1 West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, P.R. China.

Background: Previous studies have reported that polymorphisms in the interleukin-1 gene may be involved in tumorigenesis and tumor progression.

Aim: The purpose of the present study was to evaluate whether an insertion/deletion polymorphism, rs3783553, located in the miR-122 target gene interleukin-1α, was associated with the risk of colorectal cancer.

Methods: Genomic DNA was extracted from peripheral venous blood of 382 patients with colorectal cancer and 433 controls, and the polymorphism was genotyped using a polymerase chain reaction assay. Read More

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http://dx.doi.org/10.1177/1724600818785069DOI Listing
July 2018
10 Reads

Prognostic value of platelet-to-lymphocyte ratio in oncologic outcomes of esophageal cancer: what should we expect from a meta-analysis?

Int J Biol Markers 2018 Jul 1:1724600818785128. Epub 2018 Jul 1.

2 Laboratory of Experimental Surgery and Surgical Research, University of Athens, Medical School, Athens, Greece.

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http://dx.doi.org/10.1177/1724600818785128DOI Listing
July 2018
11 Reads

Establishment of the reference interval for serum pro-gastrin-releasing peptide in healthy adults of Chinese Han ethnicity.

Int J Biol Markers 2018 Nov 6;33(4):487-491. Epub 2018 Jul 6.

1 Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital, Zhejiang, China.

Objective:: The aim of this study is to establish the reference interval for serum pro-gastrin-releasing peptide (proGRP) determined by electrochemiluminescence immunoassay (ECLIA) in healthy Chinese Han ethnic adults.

Methods:: After screening, 9932 healthy Chinese Han adults (age range 18-95 years) were enrolled in this study, including 6220 men and 3712 women. Serum proGRP levels were measured by ECLIA. Read More

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http://dx.doi.org/10.1177/1724600818783416DOI Listing
November 2018
28 Reads
1.360 Impact Factor

Fecal fusobacterium nucleatum for detecting colorectal cancer: a systematic review and meta-analysis.

Int J Biol Markers 2018 Jul 1:1724600818781301. Epub 2018 Jul 1.

2 Department of Oncology, Fuzhou General Hospital, Fujian, P.R. China.

Objective: The purpose of this systematic review and meta-analysis was to evaluate the efficacy of fecal Fusobacterium nucleatum ( Fn) for detecting colorectal cancer. It is the first systematic review and meta-analysis to focus exclusively on fecal Fn for colorectal cancer.

Materials And Methods: Comprehensive searches of several databases before January 2018 were conducted. Read More

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http://dx.doi.org/10.1177/1724600818781301DOI Listing
July 2018
33 Reads

Prostate cancer grading in 2018: limitations, implementations, cribriform morphology, and biological markers.

Int J Biol Markers 2018 Nov 27;33(4):331-334. Epub 2018 Jun 27.

1 Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.

The Gleason grading system is among the most important prognostic factors in patients with prostate cancer. From the 2005 to the 2014 consensus conferences, organized by the International Society of Urological Pathology, the morphologic criteria for the identification of the Gleason patterns were redefined, thus resulting in the shrinkage of the Gleason pattern 3. This led to the expansion of the Gleason pattern 4. Read More

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http://dx.doi.org/10.1177/1724600818781296DOI Listing
November 2018
42 Reads

Coexistence of three EGFR mutations in an NSCLC patient: A brief report.

Int J Biol Markers 2018 Jun 1:1724600818782200. Epub 2018 Jun 1.

1 Dipartimento di Medicina Molecolare, Sapienza Università di Roma, Roma, Italia.

Background: The epidermal growth factor receptor (EGFR) represents a molecular target for tyrosine kinase inhibitors for non-small cell lung cancer (NSCLC) patients with a mutation in the EGFR gene. Mutations of the EGFR gene that occur at a single position in NSCLC tissue are found as single, whereas two or more mutations on the same allele are poorly detected and investigated.

Patient And Methods: We investigated the presence of the EGFR gene mutations in tumor tissue by Sanger sequencing and ion torrent sequencing in an NSCLC patient at Stage IV of disease. Read More

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http://dx.doi.org/10.1177/1724600818782200DOI Listing
June 2018
3 Reads
1.360 Impact Factor

Cortisol, cortisone, and 4-methoxyphenylacetic acid as potential plasma biomarkers for early detection of non-small cell lung cancer.

Int J Biol Markers 2018 Aug 13;33(3):314-320. Epub 2018 Jun 13.

1 Department of Medical Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China.

Background: Lung cancer is the most common cause of cancer-related deaths in men and women worldwide. Novel diagnostic biomarkers are urgently required to enable the early detection and treatment of lung cancer, and using novel methods to explore tumor-related biomarkers is a hot topic in lung cancer research. The purpose of this study was to use ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS) metabolomics analysis technology combined with multivariate data processing methods to identify potential plasma biomarkers for non-small cell lung cancer (NSCLC). Read More

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http://dx.doi.org/10.1177/1724600818778754DOI Listing
August 2018
10 Reads

Reference intervals for serum progastrin-releasing peptide in healthy Chinese adults with electrochemiluminescence immunoassay.

Int J Biol Markers 2018 May 1:1724600818776828. Epub 2018 May 1.

Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

Background: Reliable reference intervals for serum progastrin-releasing peptide (ProGRP) in healthy Chinese adults with electrochemiluminescence immunoassay (ECLIA) are still lacking in the Chinese population.

Objectives: The study aims to establish reference intervals for ProGRP with ECLIA in apparently healthy Chinese adults.

Methods: A total of 384 apparently healthy individuals from six representative geographical regions in China were enrolled: 200 males and 184 females with a mean age of 43. Read More

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http://dx.doi.org/10.1177/1724600818776828DOI Listing
May 2018
4 Reads

Long non-coding RNA PVT1 as a novel potential biomarker for predicting the prognosis of colorectal cancer.

Int J Biol Markers 2018 May 1:1724600818777242. Epub 2018 May 1.

2 Department of General Surgery, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China.

Background: Long non-coding RNA (lncRNA) plays a very important role in the occurrence and development of various tumors, and is a potential biomarker for cancer diagnosis and prognosis. The purpose of this study was to investigate the relationship between the expression of lncRNA plasmacytoma variant translocation 1 (PVT1) and the prognostic significance in patients with colorectal cancer.

Methods: The expression of PVT1 was measured by real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in cancerous and adjacent tissues of 210 colorectal cancer patients. Read More

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http://dx.doi.org/10.1177/1724600818777242DOI Listing
May 2018
1 Read

Prognostic value of hypoxia-inducible factor-1 alpha in nasopharyngeal carcinoma: a meta-analysis.

Int J Biol Markers 2018 Jun 1:1724600818778756. Epub 2018 Jun 1.

Department of Radiation Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Over the past 5 years, many studies have reported the prognostic value of hypoxia-inducible factor-1 alpha (HIF-1α) in nasopharyngeal carcinoma. However, the results have not reached a consensus until now. Therefore, we performed this meta-analysis to investigate the influence of HIF-1α expression on the prognosis and clinical characteristics in nasopharyngeal carcinoma. Read More

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http://dx.doi.org/10.1177/1724600818778756DOI Listing
June 2018
4 Reads

Expression signature of lysosomal-associated transmembrane protein 4B in hepatitis C virus-induced hepatocellular carcinoma.

Int J Biol Markers 2018 Aug 8;33(3):283-292. Epub 2018 Jun 8.

1 Department of Biotechnology, Molecular Virology Laboratory, Jamia Millia Islamia, New Delhi, India.

Introduction: Hepatocellular carcinoma is a lethal disease worldwide and therefore the establishment of novel diagnostic biomarkers is imperative. In this study, it was hypothesized that an abnormal expression of the lysosomal-associated protein transmembrane 4 beta ( LAPTM4B) gene is crucial in the pathogenesis of hepatitis C virus-mediated hepatocellular carcinoma; hence we investigated the expression profile of LAPTM4B in hepatitis C virus-induced hepatocellular carcinoma.

Methods: A group of 189 consecutive patients (hepatitis C virus-related hepatocellular carcinoma as tumor cases; n=93, hepatitis C virus-related cirrhotics as disease controls; n=96) opting for living donor liver transplantation as a therapeutic surgical regimen were recruited with informed consent. Read More

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http://dx.doi.org/10.1177/1724600818773631DOI Listing
August 2018
6 Reads

Diagnostic value of serum dihydrodiol dehydrogenase 2 levels in patients with non-small-cell lung cancer.

Int J Biol Markers 2018 Jun 1:1724600818776832. Epub 2018 Jun 1.

6 Center of Laboratory, Nanjing Chest Hospital, Nanjing, Jiangsu, China.

Objectives: Dihydrodiol dehydrogenase 2 (DDH2) plays an important role in pathogenesis of non-small-cell lung cancer (NSCLC). This study aimed to evaluate the value of serum DDH2 levels in NSCLC patients.

Methods: Serum samples were obtained from 863 NSCLC patients and 439 healthy controls. Read More

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http://dx.doi.org/10.1177/1724600818776832DOI Listing
June 2018
3 Reads

Prognostic implications of hepatitis B virus infection in intrahepatic cholangiocarcinoma treated with first-line gemcitabine plus cisplatin.

Int J Biol Markers 2018 Nov 6;33(4):432-438. Epub 2018 Jun 6.

1 Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Purpose:: Hepatitis B virus infection is a well-known risk factor for intrahepatic cholangiocarcinoma. However, its prognostic impact has rarely been investigated in advanced intrahepatic cholangiocarcinoma.

Methods:: Between April 2010 and May 2015, 296 patients with unresectable or metastatic intrahepatic cholangiocarcinoma who received gemcitabine plus cisplatin (GemCis) were categorized into a hepatitis B virus group (n=62; 21%) and a non-hepatitis B virus group (n=234; 79%). Read More

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http://dx.doi.org/10.1177/1724600818777239DOI Listing
November 2018
26 Reads

Prognostic significance of pretreatment plasma fibrinogen level in patients with digestive system tumors: a meta-analysis.

Int J Biol Markers 2018 Aug 6;33(3):254-265. Epub 2018 Jun 6.

1 Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China.

High pretreatment levels of plasma fibrinogen have been widely reported to be a potential predictor of prognosis in digestive system tumors; however, the conclusions are not consistent. Therefore, we performed a meta-analysis to comprehensively assess the prognostic roles of high pretreatment plasma fibrinogen levels in digestive system tumors. We searched for eligible studies in the PubMed, Embase, and Web of Science electronic databases for publications from the database inception to 1 September 2017. Read More

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http://dx.doi.org/10.1177/1724600818773627DOI Listing
August 2018
3 Reads

Plasma cholesterol and lipoprotein levels in relation to tumor aggressiveness and survival in HCC patients.

Int J Biol Markers 2018 Nov 6;33(4):423-431. Epub 2018 Jun 6.

12 Department of Medical Surgical Sciences, Medical Semiotics Unit, Alma Mater Studiorum, University of Bologna, Italy.

Background And Aims:: Hepatocellular carcinoma is associated with several chronic liver diseases, especially chronic hepatitis B virus, hepatitis C virus, and alcoholism. It is increasingly appreciated that obesity/metabolic syndrome is also associated with chronic liver disease and subsequent hepatocellular carcinoma.

Methods:: We retrospectively investigated the serum lipid profiles in a large hepatocellular carcinoma cohort, associated predominantly with the hepatitis B virus, hepatitis C virus, alcohol or nonalcoholic steatohepatitis. Read More

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http://dx.doi.org/10.1177/1724600818776838DOI Listing
November 2018
15 Reads

Clinicopathological significance and diagnostic approach of ROS1 rearrangement in non-small cell lung cancer: a meta-analysis: ROS1 in non-small cell lung cancer.

Int J Biol Markers 2018 Jun 1:1724600818772194. Epub 2018 Jun 1.

3 Department of Pathology, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea.

Purpose: The aim of this study was to investigate the rate of ROS1 rearrangement and concordance between ROS1 immunohistochemistry (IHC) and molecular tests in non-small cell lung cancer (NSCLC).

Methods: The study included 10,898 NSCLC cases from 21 eligible studies. ROS1 rearrangement rates were evaluated in NSCLC by a meta-analysis, including subgroup analyses. Read More

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http://dx.doi.org/10.1177/1724600818772194DOI Listing
June 2018
5 Reads
1.360 Impact Factor