1,561 results match your criteria International Journal of Biological Markers[Journal]


Prognostic value of pretreatment prognostic nutritional index in non-small cell lung cancer: A systematic review and meta-analysis.

Int J Biol Markers 2018 Nov 3;33(4):372-378. Epub 2018 Oct 3.

1 Department of Endocrinology and Metabolism, Shenzhen Nanshan People's Hospital, ShenZhen, China.

Background:: The pretreatment prognostic nutritional index has been considered a potential prognostic biomarker in patients with non-small cell lung cancer (NSCLC), but this remains controversial. Therefore, we performed a meta-analysis to systematically assess the prognostic value of the prognostic nutritional index in patients with NSCLC.

Methods:: We systematically searched PubMed, EMBASE, Web of Science, and CNKI. Read More

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http://journals.sagepub.com/doi/10.1177/1724600818799876
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http://dx.doi.org/10.1177/1724600818799876DOI Listing
November 2018
3 Reads

Clinical significance of fucosylated GP73 in the differential diagnosis of hepatocellular carcinoma.

Int J Biol Markers 2018 Nov 21;33(4):439-446. Epub 2018 Sep 21.

1 Department of Clinical Laboratory, The First Hospital of Qinhuangdao, Qinhuangdao, China.

Objective:: To investigate the clinical value of fucosylated GP73 (Fuc-GP73) levels for differential diagnosis of hepatocellular carcinoma from other liver diseases.

Methods:: Serum specimens were collected from 50 patients with hepatocellular carcinoma, 60 patients with other digestive system diseases (ODSD), and 40 normal controls. Lectin affinity chromatography column combining with the enzyme-linked immunosorbent assay (ELISA) using the ELISA index was utilized to measure the level of Fuc-GP73. Read More

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http://dx.doi.org/10.1177/1724600818796646DOI Listing
November 2018
1 Read

Relationship between GSTP1 rs1695 gene polymorphism and myelosuppression induced by platinum-based drugs: a meta-analysis.

Int J Biol Markers 2018 Sep 21:1724600818792897. Epub 2018 Sep 21.

3 First Department of Cancer Research Institute, the First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China.

Although many previous studies have reported the relationship between GSTP1 rs1695 gene polymorphism and myelosuppression induced by platinum-based drugs, the conclusions are not consistent. The aim of the study is to evaluate the association between granulocytopenia and thrombocytopenia induced by platinum-based drugs and GSTP1 rs1695 gene polymorphism by meta-analysis. A literature search was performed using the Pubmed, Embase, CNKI, and Wanfang databases, and the odds ratio (OR) and its 95% confidence interval (CI) were used to evaluate the correlation. Read More

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http://dx.doi.org/10.1177/1724600818792897DOI Listing
September 2018
8 Reads

Diagnostic and prognostic value of HE4 in female patients with primary peritoneal carcinoma.

Int J Biol Markers 2018 Sep 21:1724600818796595. Epub 2018 Sep 21.

Department of Clinical Laboratory, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, China.

Background: HE4 is a useful tumor marker for the diagnosis of ovarian, endometrial, and fallopian tube carcinoma.

Aim: The aim of our study was to investigate the value of serum HE4 compared with CA125 in the diagnosis of primary peritoneal carcinoma and the estimation of treatment response and recurrence.

Methods: Serum HE4 and CA125 concentrations were measured in both primary peritoneal carcinoma patients and benign gynecological disease controls. Read More

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http://journals.sagepub.com/doi/10.1177/1724600818796595
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http://dx.doi.org/10.1177/1724600818796595DOI Listing
September 2018
10 Reads

Carcinosarcoma of the prostate: case report with molecular and histological characterization.

Int J Biol Markers 2018 Nov 12;33(4):540-544. Epub 2018 Aug 12.

4 Pathology Unit, Morgagni Pierantoni Hospital, Forlì, Italy.

Background:: We report a case of prostatic carcinosarcoma, a rare variant of prostatic cancer, which is composed of a mixture of epithelial and mesenchymal components with a generally poor outcome.

Aims And Methods:: We aim to identify molecular alterations, in particular copy number variations of AR and c -MYC genes, methylation and expression of glutathione S-transferase P1 (GSTP1), programmed death-ligand 1 (PD-L1), AR, and phosphorylated AR expression.

Results:: We found a distinct molecular pattern between adenocarcinoma and carcinosarcoma, which was characterized by high AR copy number variation gain; positive expression of PD-L1, AR, and phosphorylated AR; low espression of GSTP1 in epithelial component. Read More

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http://dx.doi.org/10.1177/1724600818791463DOI Listing
November 2018
10 Reads

Diagnosis accuracy of serum glypican-3 level in patients with hepatocellular carcinoma: a systematic review with meta-analysis.

Int J Biol Markers 2018 Aug 2:1724600818784409. Epub 2018 Aug 2.

1 Department of Hepatobiliary Surgery, YouAn Hospital Affiliated to Capital Medical University, Beijing, China.

Background: Previous studies have evaluated the diagnostic value of serum glypican-3 in patients with hepatocellular carcinoma. However, the results remain inconsistent and even controversial. Thus, the aim of the present meta-analysis was to clarify the diagnostic accuracy of serum glypican-3 for hepatocellular carcinoma. Read More

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http://dx.doi.org/10.1177/1724600818784409DOI Listing
August 2018
2 Reads

Decreased apolipoprotein A4 and increased complement component 3 as potential markers for papillary thyroid carcinoma: A proteomic study.

Int J Biol Markers 2018 Nov 30;33(4):455-462. Epub 2018 Jul 30.

4 Department of Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background:: Thyroid carcinomas have comprised the fastest rising incidence of cancer in the past decade. Currently, the diagnosis of thyroid tumors is performed by the fine-needle aspiration biopsy (FNAB) method, which still holds some challenges and limitations, mostly in discriminating malignant and benign lesions. Therefore, the development of molecular markers to distinguish between these lesion types are in progress. Read More

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http://dx.doi.org/10.1177/1724600818787752DOI Listing
November 2018
2 Reads
1.360 Impact Factor

Stability of total prostate-specific antigen and free prostate-specific antigen after 10 years' storage.

Int J Biol Markers 2018 Jul 27:1724600818789414. Epub 2018 Jul 27.

1 Department of Immunochemistry, University Hospital and Faculty of Medicine in Pilsen, Czech Republic.

Introduction: PSA is a serine protease composed of 240 amino acids in a single polypeptide chain and is a routine parameter in prostate cancer diagnostics. The aim of our study was to test the long-term stability of tPSA and fPSA after 10 years' storage at -80°C.

Materials And Methods: We analyzed two aliquots from 55 serum samples. Read More

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http://dx.doi.org/10.1177/1724600818789414DOI Listing
July 2018
2 Reads

Association between an insertion/deletion polymorphism in the interleukin-1α gene and the risk of colorectal cancer in a Chinese population.

Int J Biol Markers 2018 Jul 1:1724600818785069. Epub 2018 Jul 1.

1 West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, P.R. China.

Background: Previous studies have reported that polymorphisms in the interleukin-1 gene may be involved in tumorigenesis and tumor progression.

Aim: The purpose of the present study was to evaluate whether an insertion/deletion polymorphism, rs3783553, located in the miR-122 target gene interleukin-1α, was associated with the risk of colorectal cancer.

Methods: Genomic DNA was extracted from peripheral venous blood of 382 patients with colorectal cancer and 433 controls, and the polymorphism was genotyped using a polymerase chain reaction assay. Read More

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http://dx.doi.org/10.1177/1724600818785069DOI Listing
July 2018
9 Reads

Prognostic value of platelet-to-lymphocyte ratio in oncologic outcomes of esophageal cancer: what should we expect from a meta-analysis?

Int J Biol Markers 2018 Jul 1:1724600818785128. Epub 2018 Jul 1.

2 Laboratory of Experimental Surgery and Surgical Research, University of Athens, Medical School, Athens, Greece.

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http://dx.doi.org/10.1177/1724600818785128DOI Listing
July 2018
4 Reads

Establishment of the reference interval for serum pro-gastrin-releasing peptide in healthy adults of Chinese Han ethnicity.

Int J Biol Markers 2018 Nov 6;33(4):487-491. Epub 2018 Jul 6.

1 Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital, Zhejiang, China.

Objective:: The aim of this study is to establish the reference interval for serum pro-gastrin-releasing peptide (proGRP) determined by electrochemiluminescence immunoassay (ECLIA) in healthy Chinese Han ethnic adults.

Methods:: After screening, 9932 healthy Chinese Han adults (age range 18-95 years) were enrolled in this study, including 6220 men and 3712 women. Serum proGRP levels were measured by ECLIA. Read More

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http://dx.doi.org/10.1177/1724600818783416DOI Listing
November 2018
19 Reads
1.360 Impact Factor

Fecal fusobacterium nucleatum for detecting colorectal cancer: a systematic review and meta-analysis.

Int J Biol Markers 2018 Jul 1:1724600818781301. Epub 2018 Jul 1.

2 Department of Oncology, Fuzhou General Hospital, Fujian, P.R. China.

Objective: The purpose of this systematic review and meta-analysis was to evaluate the efficacy of fecal Fusobacterium nucleatum ( Fn) for detecting colorectal cancer. It is the first systematic review and meta-analysis to focus exclusively on fecal Fn for colorectal cancer.

Materials And Methods: Comprehensive searches of several databases before January 2018 were conducted. Read More

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http://dx.doi.org/10.1177/1724600818781301DOI Listing
July 2018
27 Reads

Prostate cancer grading in 2018: limitations, implementations, cribriform morphology, and biological markers.

Int J Biol Markers 2018 Nov 27;33(4):331-334. Epub 2018 Jun 27.

1 Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.

The Gleason grading system is among the most important prognostic factors in patients with prostate cancer. From the 2005 to the 2014 consensus conferences, organized by the International Society of Urological Pathology, the morphologic criteria for the identification of the Gleason patterns were redefined, thus resulting in the shrinkage of the Gleason pattern 3. This led to the expansion of the Gleason pattern 4. Read More

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http://dx.doi.org/10.1177/1724600818781296DOI Listing
November 2018
38 Reads

Coexistence of three EGFR mutations in an NSCLC patient: A brief report.

Int J Biol Markers 2018 Jun 1:1724600818782200. Epub 2018 Jun 1.

1 Dipartimento di Medicina Molecolare, Sapienza Università di Roma, Roma, Italia.

Background: The epidermal growth factor receptor (EGFR) represents a molecular target for tyrosine kinase inhibitors for non-small cell lung cancer (NSCLC) patients with a mutation in the EGFR gene. Mutations of the EGFR gene that occur at a single position in NSCLC tissue are found as single, whereas two or more mutations on the same allele are poorly detected and investigated.

Patient And Methods: We investigated the presence of the EGFR gene mutations in tumor tissue by Sanger sequencing and ion torrent sequencing in an NSCLC patient at Stage IV of disease. Read More

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http://dx.doi.org/10.1177/1724600818782200DOI Listing
June 2018
2 Reads
1.360 Impact Factor

Cortisol, cortisone, and 4-methoxyphenylacetic acid as potential plasma biomarkers for early detection of non-small cell lung cancer.

Int J Biol Markers 2018 Aug 13;33(3):314-320. Epub 2018 Jun 13.

1 Department of Medical Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China.

Background: Lung cancer is the most common cause of cancer-related deaths in men and women worldwide. Novel diagnostic biomarkers are urgently required to enable the early detection and treatment of lung cancer, and using novel methods to explore tumor-related biomarkers is a hot topic in lung cancer research. The purpose of this study was to use ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS) metabolomics analysis technology combined with multivariate data processing methods to identify potential plasma biomarkers for non-small cell lung cancer (NSCLC). Read More

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http://dx.doi.org/10.1177/1724600818778754DOI Listing
August 2018
8 Reads

Reference intervals for serum progastrin-releasing peptide in healthy Chinese adults with electrochemiluminescence immunoassay.

Int J Biol Markers 2018 May 1:1724600818776828. Epub 2018 May 1.

Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

Background: Reliable reference intervals for serum progastrin-releasing peptide (ProGRP) in healthy Chinese adults with electrochemiluminescence immunoassay (ECLIA) are still lacking in the Chinese population.

Objectives: The study aims to establish reference intervals for ProGRP with ECLIA in apparently healthy Chinese adults.

Methods: A total of 384 apparently healthy individuals from six representative geographical regions in China were enrolled: 200 males and 184 females with a mean age of 43. Read More

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http://dx.doi.org/10.1177/1724600818776828DOI Listing
May 2018
3 Reads

Long non-coding RNA PVT1 as a novel potential biomarker for predicting the prognosis of colorectal cancer.

Int J Biol Markers 2018 May 1:1724600818777242. Epub 2018 May 1.

2 Department of General Surgery, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China.

Background: Long non-coding RNA (lncRNA) plays a very important role in the occurrence and development of various tumors, and is a potential biomarker for cancer diagnosis and prognosis. The purpose of this study was to investigate the relationship between the expression of lncRNA plasmacytoma variant translocation 1 (PVT1) and the prognostic significance in patients with colorectal cancer.

Methods: The expression of PVT1 was measured by real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in cancerous and adjacent tissues of 210 colorectal cancer patients. Read More

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http://dx.doi.org/10.1177/1724600818777242DOI Listing

Prognostic value of hypoxia-inducible factor-1 alpha in nasopharyngeal carcinoma: a meta-analysis.

Int J Biol Markers 2018 Jun 1:1724600818778756. Epub 2018 Jun 1.

Department of Radiation Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Over the past 5 years, many studies have reported the prognostic value of hypoxia-inducible factor-1 alpha (HIF-1α) in nasopharyngeal carcinoma. However, the results have not reached a consensus until now. Therefore, we performed this meta-analysis to investigate the influence of HIF-1α expression on the prognosis and clinical characteristics in nasopharyngeal carcinoma. Read More

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http://dx.doi.org/10.1177/1724600818778756DOI Listing
June 2018
1 Read

Expression signature of lysosomal-associated transmembrane protein 4B in hepatitis C virus-induced hepatocellular carcinoma.

Int J Biol Markers 2018 Aug 8;33(3):283-292. Epub 2018 Jun 8.

1 Department of Biotechnology, Molecular Virology Laboratory, Jamia Millia Islamia, New Delhi, India.

Introduction: Hepatocellular carcinoma is a lethal disease worldwide and therefore the establishment of novel diagnostic biomarkers is imperative. In this study, it was hypothesized that an abnormal expression of the lysosomal-associated protein transmembrane 4 beta ( LAPTM4B) gene is crucial in the pathogenesis of hepatitis C virus-mediated hepatocellular carcinoma; hence we investigated the expression profile of LAPTM4B in hepatitis C virus-induced hepatocellular carcinoma.

Methods: A group of 189 consecutive patients (hepatitis C virus-related hepatocellular carcinoma as tumor cases; n=93, hepatitis C virus-related cirrhotics as disease controls; n=96) opting for living donor liver transplantation as a therapeutic surgical regimen were recruited with informed consent. Read More

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http://dx.doi.org/10.1177/1724600818773631DOI Listing
August 2018
5 Reads

Diagnostic value of serum dihydrodiol dehydrogenase 2 levels in patients with non-small-cell lung cancer.

Int J Biol Markers 2018 Jun 1:1724600818776832. Epub 2018 Jun 1.

6 Center of Laboratory, Nanjing Chest Hospital, Nanjing, Jiangsu, China.

Objectives: Dihydrodiol dehydrogenase 2 (DDH2) plays an important role in pathogenesis of non-small-cell lung cancer (NSCLC). This study aimed to evaluate the value of serum DDH2 levels in NSCLC patients.

Methods: Serum samples were obtained from 863 NSCLC patients and 439 healthy controls. Read More

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http://dx.doi.org/10.1177/1724600818776832DOI Listing
June 2018
2 Reads

Prognostic implications of hepatitis B virus infection in intrahepatic cholangiocarcinoma treated with first-line gemcitabine plus cisplatin.

Int J Biol Markers 2018 Nov 6;33(4):432-438. Epub 2018 Jun 6.

1 Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Purpose:: Hepatitis B virus infection is a well-known risk factor for intrahepatic cholangiocarcinoma. However, its prognostic impact has rarely been investigated in advanced intrahepatic cholangiocarcinoma.

Methods:: Between April 2010 and May 2015, 296 patients with unresectable or metastatic intrahepatic cholangiocarcinoma who received gemcitabine plus cisplatin (GemCis) were categorized into a hepatitis B virus group (n=62; 21%) and a non-hepatitis B virus group (n=234; 79%). Read More

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http://dx.doi.org/10.1177/1724600818777239DOI Listing
November 2018
21 Reads

Prognostic significance of pretreatment plasma fibrinogen level in patients with digestive system tumors: a meta-analysis.

Int J Biol Markers 2018 Aug 6;33(3):254-265. Epub 2018 Jun 6.

1 Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China.

High pretreatment levels of plasma fibrinogen have been widely reported to be a potential predictor of prognosis in digestive system tumors; however, the conclusions are not consistent. Therefore, we performed a meta-analysis to comprehensively assess the prognostic roles of high pretreatment plasma fibrinogen levels in digestive system tumors. We searched for eligible studies in the PubMed, Embase, and Web of Science electronic databases for publications from the database inception to 1 September 2017. Read More

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http://dx.doi.org/10.1177/1724600818773627DOI Listing
August 2018
2 Reads

Plasma cholesterol and lipoprotein levels in relation to tumor aggressiveness and survival in HCC patients.

Int J Biol Markers 2018 Nov 6;33(4):423-431. Epub 2018 Jun 6.

12 Department of Medical Surgical Sciences, Medical Semiotics Unit, Alma Mater Studiorum, University of Bologna, Italy.

Background And Aims:: Hepatocellular carcinoma is associated with several chronic liver diseases, especially chronic hepatitis B virus, hepatitis C virus, and alcoholism. It is increasingly appreciated that obesity/metabolic syndrome is also associated with chronic liver disease and subsequent hepatocellular carcinoma.

Methods:: We retrospectively investigated the serum lipid profiles in a large hepatocellular carcinoma cohort, associated predominantly with the hepatitis B virus, hepatitis C virus, alcohol or nonalcoholic steatohepatitis. Read More

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http://dx.doi.org/10.1177/1724600818776838DOI Listing
November 2018
12 Reads

Clinicopathological significance and diagnostic approach of ROS1 rearrangement in non-small cell lung cancer: a meta-analysis: ROS1 in non-small cell lung cancer.

Int J Biol Markers 2018 Jun 1:1724600818772194. Epub 2018 Jun 1.

3 Department of Pathology, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea.

Purpose: The aim of this study was to investigate the rate of ROS1 rearrangement and concordance between ROS1 immunohistochemistry (IHC) and molecular tests in non-small cell lung cancer (NSCLC).

Methods: The study included 10,898 NSCLC cases from 21 eligible studies. ROS1 rearrangement rates were evaluated in NSCLC by a meta-analysis, including subgroup analyses. Read More

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http://dx.doi.org/10.1177/1724600818772194DOI Listing
June 2018
3 Reads
1.360 Impact Factor

Expression of PD-L1/PD-L2 is associated with high proliferation index of Ki-67 but not with TP53 overexpression in chondrosarcoma.

Int J Biol Markers 2018 May 1:1724600818774464. Epub 2018 May 1.

1 Department of Orthopaedics Surgery, The First Affiliated Hospital of Soochow University, China.

Purpose: Chondrosarcoma is a malignancy affecting cartilage and is chemo- and radio-resistant. Novel immune checkpoint inhibitors may play a role in treatment; however, expression of programmed cell death ligand 1/2 (PD-L1/PD-L2) in chondrosarcoma is unreported.

Methods: Chondrosarcoma sections were collected and stained immunohistochemically for PD-L1, PD-L2, Ki-67, and TP53. Read More

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http://dx.doi.org/10.1177/1724600818774464DOI Listing
May 2018
3 Reads

Long non-coding RNA SNHG6 promotes glioma tumorigenesis by sponging miR-101-3p.

Int J Biol Markers 2018 May;33(2):148-155

1 Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an - China.

Introduction: Glioma is the most common primary brain tumor. The small nucleolar RNA host gene (SNHG) SNHG6 is a potential oncogene in the development of several types of cancers.

Methods: In this study, we investigated the functional role of long non-coding RNA (lncRNA) SNHG6 in the malignancy of glioma in cell lines and transplanted nude mice. Read More

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http://dx.doi.org/10.1177/1724600817747524DOI Listing
May 2018
3 Reads

Diagnostic value of CD56 immunohistochemistry in thyroid lesions.

Int J Biol Markers 2018 May;33(2):161-167

2 Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul - Republic of Korea.

Purpose: The present study aimed to evaluate the diagnostic roles of CD56 immunohistochemistry in differentiating various thyroid lesions.

Methods: A meta-analysis was performed to evaluate the rate of loss of CD56 immunohistochemistry expression from 13 eligible studies regarding various thyroid lesions, including papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. To confirm the value of CD56 immunohistochemistry in differentiating various thyroid lesions, a diagnostic test accuracy review was conducted. Read More

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http://dx.doi.org/10.1177/1724600817748538DOI Listing
May 2018
2 Reads
1.360 Impact Factor

Deciphering the potential value of 5-fluorouracil metabolic enzymes in predicting prognosis and treatment response of colorectal cancer patients.

Int J Biol Markers 2018 May;33(2):180-188

1 Tumor Biology Lab 2, Cancer Biology Department, The Gujarat Cancer & Research Institute, NCH Compound, Asarwa, Ahmedabad, Gujarat- India.

Introduction: 5-flourouracil (5-FU) is one of the standard chemotherapeutic drugs used today in the treatment of colorectal cancer patients. Disruption of 5-FU metabolic pathway may contribute to altered effectiveness towards 5-FU-based therapy. Hence, the study of 5-FU metabolizing enzymes might have the potential efficacy to predict survival and response to treatment in colorectal cancer patients. Read More

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http://dx.doi.org/10.1177/1724600817748539DOI Listing
May 2018
4 Reads

The role of selected chemokines and their specific receptors in pancreatic cancer.

Int J Biol Markers 2018 May;33(2):141-147

3 Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok - Poland.

Pancreatic carcinoma is a highly malignant disease associated with an extremely poor prognosis, which is caused by late presentation, aggressive invasion and metastases, as well as the detection of pancreatic carcinoma in its advanced stages. Thus, better understanding of the tumour biology of this malignancy is sorely needed to improve the clinical outcome. A great challenge for the medical practice is finding a new biomarker of pancreatic carcinoma that will be helpful in diagnosis, in prognosis and in making clinical decisions, including the assessment of patients' response to therapy. Read More

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http://dx.doi.org/10.1177/1724600817753094DOI Listing
May 2018
1 Read

Intratumoral immune cells expressing PD-1/PD-L1 and their prognostic implications in cancer: a meta-analysis.

Int J Biol Markers 2018 May 1:1724600818770941. Epub 2018 May 1.

1 Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.

Background: The prognostic value of immune cells expressing programmed cell death 1 (PD-1) and PD-1 ligand 1 (PD-L1) in cancer are controversial, and the potential differential impact of using tissue microarrays and whole tissue sections to assess the positivity of immune cells has not been addressed.

Methods: The current study included 30 eligible studies with 7251 patients that evaluated the relationship between tumor-infiltrating lymphocytes expressing PD-1/PD-L1 and overall survival and disease-free survival, or progression-free survival. Subgroup analysis was based on the tissue type of cancer and the type of tissue sampling (tissue microarray or whole tissue section). Read More

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http://dx.doi.org/10.1177/1724600818770941DOI Listing
May 2018
5 Reads
1.360 Impact Factor

The role of miR-92b in cholangiocarcinoma patients.

Int J Biol Markers 2018 Aug 11;33(3):293-300. Epub 2018 May 11.

Department of Geriatric Oncology, The First Affiliated Hospital of the People's Liberation Army General Hospital, Beijing, P.R. China.

Purpose: The role of microRNA (miRNA) in cholangiocarcinoma was not clear. The aim of this study was to find the potential diagnostic and prognostic miRNA in cholangiocarcinoma patients.

Methods: The miRNA expression profiles in cholangiocarcinoma patients from The Cancer Genome Atlas and Gene Expression Omnibus (GSE53870) were analyzed. Read More

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http://dx.doi.org/10.1177/1724600817751524DOI Listing

Genetic variants in macrophage colony-stimulating factor are associated with risk of renal cell carcinoma in a Chinese population.

Int J Biol Markers 2018 Aug 8;33(3):321-328. Epub 2018 May 8.

1 Department of Urology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China.

Objective: This study was performed to investigate whether CSF-1 polymorphisms influenced the risk of renal cell carcinoma in a Chinese population.

Methods: The potentially functional polymorphisms in CSF-1 (rs333951 and rs2050462) were genotyped in this hospital-based case-control study, comprising 1512 renal cell carcinoma patients and 1691 controls in a Chinese population using the TaqMan assay. Furthermore, odds ratios (ORs) and 95% confidence intervals (CI) were used to estimate such an association. Read More

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http://dx.doi.org/10.1177/1724600817748879DOI Listing

Discordant prostate specific antigen test results despite WHO assay standardization.

Int J Biol Markers 2018 Aug 8;33(3):275-282. Epub 2018 May 8.

1 Department of Urology, Prostate Center, University Hospital Münster, Muenster, Germany.

Introduction: Total PSA (tPSA) and free PSA (fPSA) are the most commonly used biomarkers for early detection of prostate cancer. Despite standardization efforts, many available PSA assays may still produce discordant results. In the present study, we compared four PSA assays calibrated to the WHO standards 96/670 and 96/668 for tPSA and fPSA, respectively. Read More

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http://dx.doi.org/10.1177/1724600818754750DOI Listing
August 2018
15 Reads

Association between interleukin-10 -592 A/C polymorphism and gastrointestinal tract cancer risk: A meta-analysis.

Int J Biol Markers 2018 Aug 3;33(3):244-253. Epub 2018 May 3.

Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Recent evidence suggests that -592 A/C polymorphism in the interleukin-10 (IL-10) gene may influence risk of gastrointestinal tract cancer; however, individual studies have provided conflicting and inconclusive results. Therefore, this meta-analysis was conducted to assess the association between IL-10 -592 A/C polymorphism and gastrointestinal tract cancer susceptibility.

Methods: EMBASE, PubMed, Web of Science, and China National Knowledge Infrastructure databases were searched for case-control studies published before 1 May 2017. Read More

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http://dx.doi.org/10.1177/1724600817747525DOI Listing

Circulating tumor DNA as prognostic markers for late stage NSCLC with bone metastasis.

Int J Biol Markers 2018 May 1;33(2):222-230. Epub 2018 May 1.

2 Department of Orthopedics, Renmin Hospital of Wuhan University - China.

Purpose: Bone metastases from non-small cell lung cancer (NSCLC) are common, and current prognostic stratification methods are challenging to predict outcomes. The aim of the study is to examine circulating tumor DNA as a potential biomarker to gauge overall survival.

Methods: Late stage NSCLC patients associated with bone metastasis were recruited for the study. Read More

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http://dx.doi.org/10.1177/1724600817753576DOI Listing
May 2018
9 Reads

Development of a novel diagnostic algorithm to predict NASH in HCV-positive patients.

Int J Biol Markers 2018 May 1;33(2):231-236. Epub 2018 May 1.

1 Xeptagen S.p.A. - Italy.

Non-alcoholic steato-hepatitis (NASH) is a severe disease characterised by liver inflammation and progressive hepatic fibrosis, which may progress to cirrhosis and hepatocellular carcinoma. Clinical evidence suggests that in hepatitis C virus patients steatosis and NASH are associated with faster fibrosis progression and hepatocellular carcinoma. A safe and reliable non-invasive diagnostic method to detect NASH at its early stages is still needed to prevent progression of the disease. Read More

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http://dx.doi.org/10.1177/1724600817753577DOI Listing
May 2018
1 Read

High expression of Aurora-B is correlated with poor prognosis and drug resistance in non-small cell lung cancer.

Int J Biol Markers 2018 May 30;33(2):215-221. Epub 2018 Apr 30.

Departments of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi - P.R. China.

Objective: Aurora kinase B (Aurora-B) is a crucial regulator of accurate mitosis. Abnormal Aurora-B expression is associated with aneuploidy and has been implicated in the pathogenesis and drug resistance in a variety of human cancers. However, little evidence is available regarding the role of Aurora-B in regulating drug response in non-small cell lung cancer (NSCLC), which is the most common type of lung cancer, and is characterized with poor prognosis and high mortality. Read More

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http://dx.doi.org/10.1177/1724600817753098DOI Listing
May 2018
4 Reads
1 Citation
1.360 Impact Factor

Procalcitonin as a postoperative marker in the follow-up of patients affected by medullary thyroid carcinoma.

Int J Biol Markers 2018 May 30;33(2):156-160. Epub 2018 Apr 30.

2 Endocrinology Unit, Regina Elena National Cancer Institute, Rome - Italy.

Aim: Due to the limits of calcitonin, other markers are warranted to better manage medullary thyroid carcinoma patients, and procalcitonin has been reported as promising. Here we aimed to evaluate procalcitonin as a marker of medullary thyroid carcinoma in the post-treatment follow-up.

Methods: Medullary thyroid carcinoma patients previously treated by thyroidectomy were enrolled. Read More

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http://dx.doi.org/10.1177/1724600817747518DOI Listing
May 2018
8 Reads

E2F1 genetic variants and risk of cervical cancer in Indian women.

Int J Biol Markers 2018 Apr 1:1724600818768459. Epub 2018 Apr 1.

1 Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Himachal Pradesh, India.

Introduction: Altered expression of many E2F family members have been reported in various human cancers. In this study, we investigated the role of non-synonymous single nucleotide polymorphisms (rs3213172 C/T, rs3213173 C/T, and rs3213176 G/A) of the gene E2F1 with cervical cancer.

Methods: A total of 181 samples including 90 cervical cancer patients and 91 healthy controls were genotyped. Read More

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http://dx.doi.org/10.1177/1724600818768459DOI Listing
April 2018
3 Reads

A link between expression level of long-non-coding RNA ZFAS1 in breast tissue of healthy women and obesity.

Int J Biol Markers 2018 Apr 1:1724600818762258. Epub 2018 Apr 1.

1 Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Epidemiological and experimental literature indicates that the risk of breast cancer incidence is strongly linked to hormone-dependent factors, including reproductive history and obesity. However, the molecular mechanisms underlying the association between these factors and breast cancer risk are poorly understood. The aim of this study, therefore, was to determine whether obesity and reproductive history are associated with expression levels of two breast cancer-related long non-coding RNAs (lncRNAs), namely ZFAS1 and SRA1 in cancer-free breast tissues of women. Read More

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http://dx.doi.org/10.1177/1724600818762258DOI Listing
April 2018
9 Reads
1.360 Impact Factor

Characterization of a rare variant (c.2635-2A>G) of the MSH2 gene in a family with Lynch syndrome.

Int J Biol Markers 2018 Apr 24:1724600818766496. Epub 2018 Apr 24.

1 Medical Genetics, National Institute of Gastroenterology, IRCCS "S. De Bellis," Castellana Grotte, Bari, Italy.

Introduction: Lynch syndrome is caused by germline mutations in one of the mismatch repair genes ( MLH1, MSH2, MSH6, and PMS2) or in the EPCAM gene. Lynch syndrome is defined on the basis of clinical, pathological, and genetic findings. Accordingly, the identification of predisposing genes allows for accurate risk assessment and tailored screening protocols. Read More

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http://dx.doi.org/10.1177/1724600818766496DOI Listing
April 2018
17 Reads

Polymorphisms in the TOX3/LOC643714 and risk of breast cancer in south China.

Int J Biol Markers 2018 Apr 1:1724600818755633. Epub 2018 Apr 1.

1 Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.

Objective: Breast cancer is the most widespread cancer in women, with a high mortality rate. This study aims to assess the association between single nucleotide polymorphisms (SNPs) of LOC643714 (rs12922061) and TOX3 (rs3803662) and breast cancer, as well as the clinical characteristics of tumors.

Materials And Methods: In total, 104 breast cancer patients and 118 healthy controls were recruited to our study. Read More

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http://dx.doi.org/10.1177/1724600818755633DOI Listing
April 2018
4 Reads
1.360 Impact Factor

Prognostic value of platelet-to-lymphocyte ratio in oncologic outcomes of esophageal cancer: A systematic review and meta-analysis.

Int J Biol Markers 2018 Apr 1:1724600818766889. Epub 2018 Apr 1.

1 Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.

The platelet-to-lymphocyte ratio (PLR) is a useful prognostic factor in several cancers. However, the prognostic role of PLR in esophageal cancer remains controversial. The aim of this study is to evaluate the association between PLR and the oncologic outcome of esophageal cancer patients through a meta-analysis. Read More

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http://journals.sagepub.com/doi/10.1177/1724600818766889
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http://dx.doi.org/10.1177/1724600818766889DOI Listing
April 2018
6 Reads

Frequency distribution of BLMH, XPO5 and HFE gene polymorphisms in the South Indian population and their association with Hodgkin Lymphoma.

Int J Biol Markers 2018 Mar 1:1724600818766502. Epub 2018 Mar 1.

3 Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Gorimedu, Puducherry, India.

Background: Hodgkin lymphoma, a highly curable malignancy is currently treated with an adriamycin, bleomycin (BLM), vinblastine, and dacarbazine (ABVD) regimen. BLM-induced pulmonary toxicity (BPT) is one of the dose-limiting toxicities. Previous reports have revealed that genetic variants rs1050565, rs11077, and rs1800562 are involved in the development of BPT. Read More

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http://journals.sagepub.com/doi/10.1177/1724600818766502
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http://dx.doi.org/10.1177/1724600818766502DOI Listing
March 2018
3 Reads

The new world of RNA biomarkers and explorers' prudence rules.

Int J Biol Markers 2018 08 23;33(3):239-243. Epub 2018 Apr 23.

Center for Molecular Systems Biology and Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy.

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http://dx.doi.org/10.1177/1724600818764071DOI Listing

Plasma long non-coding RNA HOTAIR as a potential biomarker for gastric cancer.

Int J Biol Markers 2018 Apr 1:1724600818760244. Epub 2018 Apr 1.

4 Surgery Department, Alexandria University, Egypt.

Background: Long non-coding RNAs (lncRNAs) Hox transcript antisense intergenic RNA ( HOTAIR) has been suggested to be implicated in gastric cancer tumorigenesis and progression; however, little is known about the role of the plasma HOTAIR in gastric cancer diagnosis and prognosis.

Objective: The current study was aimed at investigating the clinical relevance of plasma long non-coding HOTAIR as a non-invasive diagnostic biomarker in gastric cancer.

Methods: Plasma HOTAIR expression was measured in 50 patients with newly diagnosed gastric cancer and 50 age- and sex-matched healthy controls using quantitative reverse transcription polymerase chain reaction. Read More

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http://dx.doi.org/10.1177/1724600818760244DOI Listing
April 2018
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CD44 overexpression related to lymph node metastasis and poor prognosis of pancreatic cancer.

Int J Biol Markers 2018 Aug 23;33(3):308-313. Epub 2018 Apr 23.

2 Department of Gastrointestinal Surgery, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Background: CD44 has recently been reported as a biomarker for pancreatic cancer. However, the predictive value of CD44 in pancreatic cancer remains controversial. Therefore, we performed this meta-analysis to evaluate the association between the expression of CD44 and clinicopathological features, and the outcome of pancreatic cancer patients. Read More

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http://journals.sagepub.com/doi/10.1177/1724600817746951
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http://dx.doi.org/10.1177/1724600817746951DOI Listing
August 2018
4 Reads

Lysine-specific demethylase 2A expression is associated with cell growth and cyclin D1 expression in colorectal adenocarcinoma.

Int J Biol Markers 2018 Apr 1:1724600818764069. Epub 2018 Apr 1.

1 Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.

Objective: Lysine-specific demethylase 2A (KDM2A), a specific H3K36me1/2 demethylase, has been reported to be closely associated with several types of cancer. In this study, we aimed to investigate the expression and function of KDM2A in colorectal adenocarcinoma.

Methods: A total of 215 colorectal adenocarcinoma specimens were collected, and then subjected to immunohistochemistry assay to evaluate the expression levels of KDM2A, cyclin D1 and other proteins in colorectal adenocarcinoma tissues. Read More

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http://dx.doi.org/10.1177/1724600818764069DOI Listing

Identification of circulating microRNAs as diagnostic biomarkers for ovarian cancer:A pooled analysis of individual studies.

Int J Biol Markers 2018 Apr 1:1724600818766500. Epub 2018 Apr 1.

Department of Gynecology and Obstetrics, the People's Hospital of Three Gorges University/The First People's Hospital of Yichang, Yichang, China.

Background: Circulating microRNAs (miRNAs) are proposed as promising non-invasive diagnostic biomarkers for many cancers. However, the diagnostic value of circulating miRNAs in ovarian cancer is inconsistent in different studies. Thus we performed this meta-analysis to systematically evaluate the diagnostic value of circulating miRNAs in ovarian cancer. Read More

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http://dx.doi.org/10.1177/1724600818766500DOI Listing

Anaplastic lymphoma kinase immunohistochemistry scores do not predict sensitivity to crizotinib in fluorescence in situ hybridization-positive non-small cell lung cancer patients.

Int J Biol Markers 2018 Apr 1:1724600818754763. Epub 2018 Apr 1.

3 Section of Anatomic Pathology and Histology, Department of Experimental Medicine, University of Perugia Medical School, Perugia, Italy.

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http://dx.doi.org/10.1177/1724600818754763DOI Listing