10,955 results match your criteria International Journal of Biological Macromolecules [Journal]


Performance of chitosan engraved iron and lanthanum mixed oxyhydroxide for the detoxification of hexavalent chromium.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

Department of Chemistry, The Gandhigram Rural Institute - Deemed to be University, Gandhigram, 624 302 Dindigul, Tamil Nadu, India. Electronic address:

The iron - lanthanum mixed oxyhydroxide (FLMOH) and chitosan engraved iron - lanthanum mixed oxyhydroxide materials (CSFLMOH) were prepared successfully and utilized for the hexavalent chromium adsorption studies. The physicochemical properties of pristine and Cr(VI) treated adsorbents were characterized using XRD, FTIR, SEM with EDX, TGA and DSC analysis. The efficacy of the CSFLMOH was compared with FLMOH towards the uptake of Cr(VI) ions and was explored using batch technique under various influencing parameters viz. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.101DOI Listing
February 2019

Dynamic oligomerization of hRAGE's transmembrane and cytoplasmic domains within SDS micelles.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

Department of Biological Sciences (Biochemistry Program), Faculty of Science, Kuwait University, P.O. Box 5969, 13060, Kuwait.

The human Receptor for Advanced Glycation End Products (hRAGE) is a pattern recognition receptor implicated in inflammation and adhesion. It is involved in both innate and adaptive immunity. Its aberrant signaling is tied to the pathogenesis of diabetic complications, neurodegenerative disorders, and chronic inflammatory responses. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.108DOI Listing
February 2019

Investigation the interaction between procyanidin dimer and α-glucosidase: Spectroscopic analyses and molecular docking simulation.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China. Electronic address:

Procyanidins are reported to inhibit α-glucosidase, which may be a useful attribute for developing functional foods that control post-prandial blood sugar levels. At present, the nature of the molecular interaction between procyanidins and α-glucosidase is poorly understood. In this study, spectroscopic analyses and computer simulations were used to investigate the interactions between α-glucosidase and B-type procyanidin dimer (BPD). Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.105DOI Listing
February 2019

Comparison and structural characterization of polysaccharides from natural and artificial Se-enriched green tea.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

Institute of Food Engineering, College of Life & Environment Science, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, PR China. Electronic address:

Se-enriched green tea has been widely used as a functional food and disease prevention. In this study, two kinds of homogeneous polysaccharides namely ASe-TPS2 and NSe-TPS2 were obtained from artificial and natural Se-enriched teas with the molecular weights of 6.73 × 10 Da and 2. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.102DOI Listing
February 2019

Hydrothermal encapsulation of lanthanum oxide derived Aegle marmelos admixed chitosan bead system for nitrate and phosphate retention.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

Department of Chemistry, Anna University, University College of Engineering - Dindigul, Reddiyarchatram, Dindigul 624 622, Tamilnadu, India. Electronic address:

The potential of hydrothermal technology was utilized for the preparation of promising adsorbents in order to overcome the troubles of methemoglobinemia (blue baby syndrome) and eutrophication which is caused by excess nitrate (NO) and phosphate (PO) ions in water. Hence, in the present investigation, the chitosan encapsulated lanthanum oxide (LaO) admixed Aegle marmelos(AM) (LaOAM@CS) composite beads was prepared by both in situ precipitation (In situ) and hydrothermal (Hydro) methods for NO and PO adsorption. The hydro supported LaOAM@CS composite beads hold an enhanced nitrate and phosphate sorption capacity (SC) of 27. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.106DOI Listing
February 2019

Truncation of κ‑carrageenase for higher κ‑carrageenan oligosaccharides yield with improved enzymatic characteristics.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

College of Biological Science and Engineering, Fujian Provincial Key Laboratory of Marine Enzyme Engineering, Fuzhou University, China, 350108. Electronic address:

Carrageenase is useful for preparation of carrageenan oligosaccharides, which have significant bioactivity. We expressed a κ‑carrageenase gene from Zobellia sp. ZL-4 in full-length (κ-ZL-4) or after truncation of the carbohydrate binding module and the Type-IX secretion module (κ-ZL-4-GH16). Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.109DOI Listing
February 2019

Self-assembly, functionality, and in-vitro properties of quercetin loaded nanoparticles based on shellac-almond gum biological macromolecules.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

Particle and Interfacial Technology Group (PaInT), Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, Gent 9000, Belgium.

Quercetin-fortified nanoparticles were prepared from almond gum (AG), a novel biological macromolecule, and Tween 80 (T80) as stabilizers and shellac (SH) as core material using an antisolvent precipitation method. The final nanoparticles were prepared by 0.67% SH, 0. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.071DOI Listing
February 2019

An In Vitro elucidation of the antiaggregatory potential of Diosmin over thermally induced unfolding of hen egg white lysozyme; A preventive quest for lysozyme amyloidosis.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

Protein Amyloid Research Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, UP 202002, India. Electronic address:

Protein misfolding diseases are associated with human pathologies. These neurodegenerative diseases remain challenging task for researchers because of their adverse effect on vital organs system. Lysozyme amyloidosis is also associated with multi-organ dysfunction. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.107DOI Listing
February 2019

Deep eutectic solvents as simultaneous plasticizing and crosslinking agents for starch.

Int J Biol Macromol 2019 Feb 18. Epub 2019 Feb 18.

West Pomeranian University of Technology, Faculty of Chemical Technology and Engineering, Polymer Institute, Ul. Pulaskiego 10, 70-322 Szczecin, Poland; New Era Materials, Sp. z o.o., ul. Komandosow 1/7, 32-085 Modlniczka, Poland.

The aim of this work was to prepare deep eutectic solvents (DES) made with choline salts with α-hydroxylate anions and glycerol and apply them as starch plasticizers. Additionally, crosslinking potential of polyfunctional anions from the salts was investigated. Starch/DES premixtures were thermally analyzed (DSC, TGA). Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.103DOI Listing
February 2019

Enhancement of the thermostability of halohydrin dehalogenase from Agrobacterium radiobacter AD1 by constructing a combinatorial smart library.

Int J Biol Macromol 2019 Feb 18. Epub 2019 Feb 18.

College of Pharmacy and Bioengineering, Chengdu University, Chengdu, 610106, China. Electronic address:

Halohydrin dehalogenase from Agrobacterium radiobacter AD1 (HheC) is a key enzyme in preparing β-substituted alcohols and optically pure epoxides. However, the weak thermostability of HheC greatly limits its industrial application and needs to be improved. In this study, a combinatorial smart library was constructed and screened for enhancing the thermostability of HheC. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.099DOI Listing
February 2019

Long non-coding RNA RP11-552M11.4 favors tumorigenesis and development of cervical cancer via modulating miR-3941/ATF1 signaling.

Int J Biol Macromol 2019 Feb 18. Epub 2019 Feb 18.

Laboratory for Advanced Interdisciplinary Research, Institutes of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

As one of the most aggressive malignancies, cervical cancer (CC) which mainly affects females has high risks of relapse and death. Long non-coding RNA (lncRNA) RP11-552M11.4 is verified to promote the progression of ovarian cancer; nevertheless, its role and the probable molecular mechanisms in CC remain unclear until the present study. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.083DOI Listing
February 2019
2.858 Impact Factor

Effect of single and dual steps annealing in combination with hydroxypropylation on physicochemical, functional and rheological properties of barley starch.

Int J Biol Macromol 2019 Feb 18. Epub 2019 Feb 18.

Department of Food Engineering and Technology, Tezpur University, Assam 784028, India. Electronic address:

Dual modification of barley starch using annealing and hydroxypropylation was carried out. The native starch was first annealed in single step and dual step. After that, hydroxypropylation of the native, single step and dual step annealed starches were performed. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.104DOI Listing
February 2019

Cloning and characterisation of Na/K-ATPase and carbonic anhydrase from oriental river prawn Macrobrachium nipponense.

Int J Biol Macromol 2019 Feb 19;129:809-817. Epub 2019 Feb 19.

Laboratory of Crustacean Development Biology and Macrobenthic Ecology, School of Life Sciences, East China Normal University, Shanghai 200241, China; State Key Laboratory of Estuarine and Coastal Research, East China Normal University, Shanghai 200241, China. Electronic address:

Na/K-ATPase (NKA) and carbonic anhydrase (CA) are ion transporters that play important roles in osmotic pressure balance in crustaceans. Oriental river prawn (Macrobrachium nipponense) is one of the most economically important shrimps in China. This species can live in freshwater and low-salt water, but the molecular mechanism of salinity regulation is unclear. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.098DOI Listing
February 2019

Inductive co-crosslinking of cellulose nanocrystal/chitosan hydrogels for the treatment of vertebral compression fractures.

Int J Biol Macromol 2019 Feb 16. Epub 2019 Feb 16.

Department of Biomedical, Biological, and Chemical Engineering, University of Missouri, Columbia, MO 65211, United States of America. Electronic address:

Vertebral compression fractures are a very common consequence of osteoporosis for which injection of a non-biodegradable, non-bioactive, mechanically-stiff polymer bone cement into the vertebral body is the most common treatment. Recently, there has been growing interest in using bioactive, degradable, and bone biomechanics-matching products as an alternative approach for treating these fractures. In this research, we focused on creating injectable, chitosan-based hydrogels that can convey mechanical strength similar to vertebral bone as well as possess inherent osteoinductivity. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.086DOI Listing
February 2019
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Microencapsulation of vitamin D using gelatin and cress seed mucilage: Production, characterization and in vivo study.

Int J Biol Macromol 2019 Feb 16. Epub 2019 Feb 16.

Department of Food Science and Technology, Faculty of Agriculture and Life Science, Cornell University, USA.

Vitamin D plays a significant role in human health and preventing diseases such as heart, immune system, and infectious problems. In this study encapsulation of vitamin D by complex coacervation with a carbohydrate (cress seed mucilage, CSM) and a protein (gelatin) was investigated. Production conditions were optimized based on ratio of core to shell, pH and CSM to gelatin volume ratio. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.096DOI Listing
February 2019

Multi-templates based molecularly imprinted sodium alginate/MnO for simultaneous enantiorecognition of lysine, alanine and cysteine isomers.

Int J Biol Macromol 2019 Feb 16;129:786-791. Epub 2019 Feb 16.

Jiangsu Key Laboratory of Advanced Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China. Electronic address:

Sodium alginate (SA) was electrodeposited onto the surface of a glassy carbon electrode (GCE), and then l-lysine (l-Lys), l-alanine (l-Ala) and l-cysteine (l-Cys) were simultaneously introduced to the surface of SA via electrostatic attractions. γ-MnO film was deposited potentiostatically onto the multi-templates immobilized SA from an aqueous mixture of KSO and MnSO. The templates of l-Lys, l-Ala and l-Cys were then oxidized and removed by cyclic voltammetry (CV) while maintaining the crystalline structures of SA and MnO. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.095DOI Listing
February 2019

Breaking the barricade of oral chemotherapy through polysaccharide nanocarrier.

Int J Biol Macromol 2019 Feb 16. Epub 2019 Feb 16.

NSHM Knowledge Campus, Kolkata Group of Institutions, 124 BL Saha Road, Kolkata 700053, West Bengal, India. Electronic address:

Oral chemotherapy is the most preferred drug administration method due to noninvasive administration, more convenient, low healthcare cost, and patient compliance in comparison to intravenous chemotherapy. However, oral chemotherapy poses numerous hurdles to drug absorption through the gastrointestinal tract. Recently, nanocarriers have been extensively used for delivering anticancer drugs orally. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.094DOI Listing
February 2019

S-protected gellan gum: Decisive approach towards mucoadhesive antimicrobial vaginal films.

Int J Biol Macromol 2019 Feb 16. Epub 2019 Feb 16.

Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria. Electronic address:

The aim of this study was to synthesize novel polymeric excipients forming mucoadhesive films for treatment of vaginal microbial infections. 2-(2-Amino ethyldisulfanyl) nicotinic acid was conjugated with gellan gum via amide bond formation. The structure of the resulting S-protected gellan gum was confirmed by H NMR. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.092DOI Listing
February 2019

Genes expression and in silico studies of functions of trehalases, a highly dispersed Anisakis simplex s. l. specific gene family.

Int J Biol Macromol 2019 Feb 16. Epub 2019 Feb 16.

Department of Biochemistry, Faculty of Biology and Biotechnology, University Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719 Olsztyn, Poland.

Trehalase plays an important role in catabolism of trehalose, disaccharide which is one of the most widespread carbohydrates in nematode tissues. This enzyme might be a major adaptation of the nematode to parasitic lifestyle. The current study revealed five trehalase isotypes of A. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.042DOI Listing
February 2019

Mouthwash containing a biosurfactant and chitosan: An eco-sustainable option for the control of cariogenic microorganisms.

Int J Biol Macromol 2019 Feb 15;129:853-860. Epub 2019 Feb 15.

Universidade Católica de Pernambuco, Rua do Príncipe, n. 526, Boa Vista, CEP: 50050-900 Recife, Pernambuco, Brazil; Instituto Avançado de Tecnologia e Inovação (IATI), Rua Joaquim de Brito, n.216, Boa Vista, CEP: 50070-280 Recife, Pernambuco, Brazil. Electronic address:

The aim of the present study was to determine the antimicrobial action and toxicity of mouthwashes formulated with a biosurfactant, chitosan of a microbial origin and peppermint (Mentha piperita) essential oil (POE). Chitosan was extracted from the biomass of a fungus from the order Mucorales grown in yam bean broth. Three biosurfactants produced by Pseudomonas aeruginosa UCP 0992 (PB), Bacillus cereus UCP 1615 (BB) and Candida bombicola URM 3718 (CB) were tested. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.090DOI Listing
February 2019

Cellulose nanofibril/silver nanoparticle composite as an active food packaging system and its toxicity to human colon cells.

Int J Biol Macromol 2019 Feb 15;129:887-894. Epub 2019 Feb 15.

Food Science Program, Division of Food Systems & Bioengineering, University of Missouri, Columbia, MO 65211, USA. Electronic address:

Cellulose nanofibrils (CNFs) and silver nanoparticles (AgNPs) are nano-sized fillers widely used for enhancing the active functions of food packaging materials. However, nanomaterials may pose unexpected toxic effects on humans. Thus, the objective of this work was to develop a novel CNF/AgNP composite and investigate its properties and cytotoxicity. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.084DOI Listing
February 2019

Fabrication of dual network self-healing alginate/guar gum hydrogels based on polydopamine-type microcapsules from mesoporous silica nanoparticles.

Int J Biol Macromol 2019 Feb 15. Epub 2019 Feb 15.

School of Chemistry and Materials Science, Ludong University, Key Laboratory of High Performance and Functional Polymer in the Universities of Shandong Province, Collaborative Innovation Center of Shandong Province for High Performance Fibers and Their Composites, Yantai, China.

In this manuscript, dual network self-healing alginate/guar gum hydrogels with polydopamine-type microcapsules from mesoporous silica nanoparticles were facilely prepared through one-pot method. Glutaraldehyde (GA) was used as a crosslinking agent to crosslink guar gum and sodium alginate, respectively. Metal-ligand interactions as reversible non-covalent bond make the dual network hydrogels have a high degree of self-healing ability, which FeCl·6HO was coordinated with sodium alginate and polydopamine on the surface of microcapsules, respectively. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.089DOI Listing
February 2019

Microparticles based on natural and synthetic polymers for cosmetic applications.

Int J Biol Macromol 2019 Feb 15. Epub 2019 Feb 15.

Nicolaus Copernicus University in Torun, Faculty of Chemistry, Gagarina 7, 87-100 Torun, Poland.

Most peeling products (exfoliators) available on the market, used in cosmetic and aesthetic dermatology applications, contain synthetic microbeads as abrasive agents. After being released into the natural environment, these non-biodegradable microparticles have an adverse impact on it, especially on aquatic ecosystems. Cosmetics consisting of solid plastic particles will be prohibited in the European Union from 2020. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.091DOI Listing
February 2019

Anti-inflammatory effects of Morchella esculenta polysaccharide and its derivatives in fine particulate matter-treated NR8383 cells.

Int J Biol Macromol 2019 Feb 15. Epub 2019 Feb 15.

School of Life Sciences, Anhui University, Hefei 230601, Anhui, PR China; Anhui Key Laboratory of Modern Biomanufacturing, Anhui University, Hefei 230601, Anhui, PR China. Electronic address:

Fine particulate matter (PM) exposure could cause many acute and chronic respiratory diseases. In this study the protective effects of polysaccharide from Morchella esculenta (FMP-1) and its derivatives against PM-induced inflammation were evaluated. By flow cytometry and ELISA analysis, sulfated polysaccharide SFMP-1 showed the best protective effect in reducing PM-induced cell death, cell apoptosis and production of tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β), which was accompanied by a diminished level in reactive oxygen species (ROS) formation caused by PM in rat alveolar macrophage NR8383 cells. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.088DOI Listing
February 2019

Fabrication and characterization of collagen-heparin-polypyrrole composite conductive film for neural scaffold.

Int J Biol Macromol 2019 Feb 15. Epub 2019 Feb 15.

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China. Electronic address:

In this work, a conductive film consisted of polypyrrole-heparin-collagen (PHC film) was fabricated as a potential neural scaffold. Heparin was initially modified with pyrrole, which was further polymerized with pyrrole monomer under the catalysis of ferric trichloride. Then collagen was added and crosslinked through amide bond, as well as physical interaction with pyrrole through hydrogen bond. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.087DOI Listing
February 2019

Synthesis and cytotoxicity of selenium nanoparticles stabilized by α-D-glucan from Castanea mollissima Blume.

Int J Biol Macromol 2019 Feb 15;129:818-826. Epub 2019 Feb 15.

College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.

A 1,6-α-D-glucan (CPA) with a high molecular weight of 2.0 × 10 kDa was isolated from the fruits of Castanea mollissima Blume. CPA showed good water solubility, low side effects on normal cells, and moderate cytotoxicity on cancer cells. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.085DOI Listing
February 2019

Design of photodynamic chitosan hydrogels bearing phthalocyanine-colistin conjugate as an antibacterial agent.

Int J Biol Macromol 2019 Feb 14. Epub 2019 Feb 14.

Department of Chemistry, Faculty of Science, Arak University, Arak 38156-8-8349, Iran. Electronic address:

The fabrication of a new antibacterial system is an essential medical requirement to treat wounds caused by multidrug-resistant Gram-negative bacteria, mostly Pseudomonas aeruginosa. Antibacterial photodynamic therapy (APDT) is an encouraging therapy modality for bacterial infection. Anyhow, the applications of most photosensitizers are restricted by their poor water solubility and their inefficiency in disruption of the outer membrane of Gram-negative bacteria. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.081DOI Listing
February 2019

Facile and rapid in-situ synthesis of chitosan-ZnO nano-hybrids applicable in medical purposes; a novel combination of biomineralization, ultrasound, and bio-safe morphology-conducting agent.

Int J Biol Macromol 2019 Feb 14. Epub 2019 Feb 14.

Department of Polymer Engineering, Faculty of Engineering, Golestan University, Gorgan, Iran.

In this study, zinc oxide nanoparticle (ZnO-NPs) and also chitosan‑zinc oxide (CS-ZnO-NPs) nano-hybrid were synthesized by a rapid ultrasound assisted co-precipitation method. The morphology, chemical bonding, crystal structure, UV absorption, toxicity and antibacterial properties of the CS-ZnO-NPs and ZnO-NPs were characterized. The FE-SEM (field emission scanning electron microscopy) micrographs and X-ray diffraction (XRD) analysis revealed that the used technique led to the preparation of homogeneous, ultra-thin (thickness of 20-30 nm) and highly pure ZnO sheets for the both kinds of nanoparticles. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.224DOI Listing
February 2019
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Synthesis of sulfonated chitosan and its antibiofilm formation activity against E. coli and S. aureus.

Int J Biol Macromol 2019 Feb 14. Epub 2019 Feb 14.

College of Material Chemistry and Chemical Engineering, Zaozhuang University, Zaozhuang, 277160, PR China. Electronic address:

A sulfonated chitosan (SCS) was prepared via nucleophilic substitution and characterized by Fourier transform infrared spectroscopy, H and C NMR spectra, gel permeation chromatography, elemental analysis, and thermo gravimetric analysis. The inhibition activities of bacterial adhesion and biofilm formation against E. coli and S. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.079DOI Listing
February 2019
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Ureido-modified carboxymethyl chitosan-graft-stearic acid polymeric nano-micelles as a targeted delivering carrier of clarithromycin for Helicobacter pylori: Preparation and in vitro evaluation.

Int J Biol Macromol 2019 Feb 14;129:686-692. Epub 2019 Feb 14.

College of Marine Life Sciences, Ocean University of China, 266003 Qingdao, China. Electronic address:

The effect of antibiotics in the stomach for curing Helicobacter pylori infection is hampered by the adverse gastric environment and low bioavailability of the administered drugs. Concerning these challenges, a polymeric nano-micelle was developed. Initially, carboxymethyl chitosan (CMCS) was hydrophobically modified with stearic acid (SA), and the obtained CMCS-g-SA co-polymers was further conjugated with urea to acquire U-CMCS-g-SA co-polymers. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.227DOI Listing
February 2019

Immobilization and stabilization of different β-glucosidases using the glutaraldehyde chemistry: Optimal protocol depends on the enzyme.

Int J Biol Macromol 2019 Feb 14;129:672-678. Epub 2019 Feb 14.

Biotechnology, Bioprocess, and Biocatalysis Group, Food Science and Technology Institute, Federal University of Rio Grande do Sul, Av. Bento Gonçalves 9500, PO Box 15090, ZC 91501-970 Porto Alegre, RS, Brazil. Electronic address:

Three β-glucosidases (Pectinex Ultra SP-L, Pectinex Ultra Clear and homemade preparation from Aspergillus niger) were immobilized using different strategies: ionic adsorption on aminated (MANAE)-agarose beads at pH 5, 7, and 9, followed by biocatalysts modification with glutaraldehyde, or on glutaraldehyde pre-activated supports. The pH of the immobilization was altered to allow different enzyme molecule orientations on the support surface. The biocatalysts from Pectinex Ultra SP-L showed the highest thermal and operational stabilities when immobilized on MANAE-agarose-glutaraldehyde at pH 7. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.057DOI Listing
February 2019

Valorization of crude glycerol based on biological processes for accumulation of lipophilic compounds.

Int J Biol Macromol 2019 Feb 14;129:728-736. Epub 2019 Feb 14.

Department of Bromatological Analysis, College of Pharmacy, Federal University of Bahia, Salvador, Bahia, Brazil.

Bacteria that are capable of accumulating lipids in their cells as storage compounds can also produce polyhydroxyalkanoates of high technological value, depending on the specific culture conditions. The objective of this study was to utilize crude glycerol from biodiesel (CGB) as a substrate, which is a major byproduct from biodiesel production, to produce lipophilic compounds. Bacillus megaterium INCQS 425 was cultivated and evaluated for the production of lipophilic compounds and the properties of these compounds were investigated. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.077DOI Listing
February 2019

Effects of repeated and continuous dry heat treatments on properties of sweet potato starch.

Int J Biol Macromol 2019 Feb 14. Epub 2019 Feb 14.

College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China. Electronic address:

The influence of repeated and continuous dry heat treatments on structural, physicochemical, and digestive properties of sweet potato starch was investigated. The results showed that the original A-type crystallinity of sweet potato starch remained unchanged after dry heat treatments. The light transmittance, gelatinization temperature, and pasting temperature of sweet potato starch increased; while the pasting viscosities, swelling power, and solubility decreased after dry heat treatments. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130183574
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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.225DOI Listing
February 2019
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Characterization and biological activities of polysaccharides from artificially cultivated Phellinus baumii.

Int J Biol Macromol 2019 Feb 14. Epub 2019 Feb 14.

Institute of Horticulture, Zhejiang Academy of Agricultural Science, Hangzhou 310021, PR China.

The polysaccharide (PPB-2) was extracted and purified from the fruiting body of artificially cultivated Phellinus baumii by an acid-chlorite delignification method. The in vitro hypoglycemic and in vivo hepatoprotective activities of PPB-2 were investigated. FT-IR spectra, NMR spectral analysis, and scanning electron microscopy were used to investigate the structural characterization of PPB-2. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.082DOI Listing
February 2019

Rat sciatic nerve regeneration across a 10-mm defect bridged by a chitin/CM-chitosan artificial nerve graft.

Int J Biol Macromol 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Biochemistry and Biomedical Materials, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, PR China; Laboratory for Marine Drugs and Bioproducts of Pilot National Laboratory for Marine Science and Technology, Qingdao 266000, PR China. Electronic address:

Chitosan as a natural bioactive biopolymer has been commonly employed in guidance conduit for repairing peripheral nerve injury, due to its excellent properties of low toxicity, antibacterial properties, high biocompatibility and biodegradability. In this study, chitin and CM-chitosan were prepared from pharmaceutical grade chitosan. Moreover, a novel composite chitosan-based nerve graft comprising microporous chitin-based conduit and internal CM-chitosan fiber was constructed and applied to bridge sciatic nerve across a 10-mm defect in SD rats. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.080DOI Listing
February 2019

Chitosan intercalated bentonite as natural adsorbent matrix for water-soluble sappanwood dye.

Int J Biol Macromol 2019 Feb 14;129:737-743. Epub 2019 Feb 14.

Department of Chemistry, Chiang Mai University, 239 Suthep, Muang, Chiang Mai 50200, Thailand.

Chitosan-bentonite clay composite was prepared for use as adsorbent matrix of water-soluble natural dyes. The addition of chitosan resulted in a relatively rough texture of the composite compared with bentonite. XRD analysis showed that a basal d-space value of the composite (15. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.078DOI Listing
February 2019
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Amine functionalization of microcrystalline cellulose assisted by (3-chloropropyl)triethoxysilane.

Int J Biol Macromol 2019 Feb 14. Epub 2019 Feb 14.

Department of Wood and Paper Science and Technology, Faculty of Natural Resources, University of Tehran, Karaj, Iran.

To improve the heavy metal adsorption of microcrystalline cellulose (MCC), two successive grafting reactions of silylation by (3-chloropropyl)triethoxysilane (CPTES) and amine-functionalization with metformin HCl were performed and the modified MCC from the first and second steps were denoted as MMCC-1 and MMCC-2, respectively. MMCCs were characterized by fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA) and compared to MCC. The presence of the amine group on the MMCC-2 surface was confirmed by FT-IR analysis. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.108DOI Listing
February 2019

Use of guar gum, gum arabic, pectin, beta-glucan and inulin for microencapsulation of anthocyanins from chokeberry.

Int J Biol Macromol 2019 Feb 13;129:665-671. Epub 2019 Feb 13.

Department of Technique and Food Development, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland. Electronic address:

The aim of this study was to use micro-encapsulation technology to create microcapsules containing anthocyanins from chokeberry with guar gum, gum arabic, pectin, β-glucan and inulin as wall material. Aqueous extracts from chokeberry fruit were enclosed and spray dried using maltodextrin as a coating material with the addition of guar gum, gum arabic, pectin, beta-glucan, and inulin respectively. Physical properties of microcapsules were tested. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.073DOI Listing
February 2019

Evaluation of structural, functional, and anti-oxidant potential of differentially extracted polysaccharides from potatoes peels.

Int J Biol Macromol 2019 Feb 14;129:778-785. Epub 2019 Feb 14.

School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, People's Republic of China; Anhui Province Key Laboratory of Functional Compound Seasoning, Anhui Qiangwang seasoning Food Co., Ltd., Jieshou 236500, People's Republic of China. Electronic address:

Potato peel was used for the extraction of three types of polysaccharides (PW, PAL, and PAC) using water, alkaline, and acid treatments, respectively. The structure of the PP polysaccharides was examined by means of Fourier transform infrared spectroscopy (FT-IR) analysis and Gas chromatography-mass spectrometry (GC-MS). The results suggest that the extracted polysaccharides constituted essentially three functional groups: CO, CH, and OH. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.074DOI Listing
February 2019
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The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.

Int J Biol Macromol 2019 Feb 13;129:653-658. Epub 2019 Feb 13.

Escola de Artes, Ciências e Humanidades, Universidade de São Paulo, 1000 Arlindo Bettio Avenue, 03828-000 São Paulo, Brazil. Electronic address:

Epoxide hydrolases (EHs) are enzymes involved in the metabolism of endogenous and exogenous epoxides, and the development of EH inhibitors has important applications in the medicine. In humans, EH inhibitors are being tested in the treatment of cardiovascular diseases and show potent anti-inflammatory effects. EH inhibitors are also considerate promising molecules against infectious diseases. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.070DOI Listing
February 2019

Structural characterization and immunomodulating activities of polysaccharides from a newly collected wild Morchella sextelata.

Int J Biol Macromol 2019 Feb 14;129:608-614. Epub 2019 Feb 14.

College of Life Sciences, Qufu Normal University, Qufu 273165, Shandong, China. Electronic address:

A purified polysaccharide was acquired from a newly collected wild Morchella. The strain identification initially showed that the strain was Morchella sextelata. This study aimed to investigate the structural features and immunomodulating activities of the polysaccharide. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130183690
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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.226DOI Listing
February 2019
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Oral administration with chitosan hydrolytic products modulates mitogen-induced and antigen-specific immune responses in BALB/c mice.

Int J Biol Macromol 2019 Feb 13. Epub 2019 Feb 13.

Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan; Center for Marine Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan. Electronic address:

The aim of this study was to investigate whether oral administration in BALB/c mice with chitosan hydrolytic products including chitosan hydrolysate, LMWC and a chitooligosaccharide mixture (oligomixture), modulates mitogen-induced and antigen-specific immune responses. A water-soluble chitosan hydrolysate was obtained via cellulase degradation of chitosan, and a LMWC and the oligomixture were separated from this hydrolysate. In non-immunized mice, both the chitosan hydrolysate and oligomixture significantly increased the phagocytic activity of peritoneal macrophages. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.068DOI Listing
February 2019

Biomineralization-inspired fabrication of chitosan/calcium carbonates core-shell type composite microparticles as a drug carrier.

Int J Biol Macromol 2019 Feb 13;129:659-664. Epub 2019 Feb 13.

Department of Materials Science, the University of Shiga Prefecture, 2500 Hassaka, Hikone, Shiga 522-8533, Japan.

Chitosan/calcium carbonate core-shell type composite microparticles were fabricated via a biomineralization-inspired process with chitosan particles as starting materials. The obtained composite particles were spherical, and the diameter of the composite particles was larger than that of the chitosan particles. XRD measurement indicated that the shell of the composite particle had a crystalline structure. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.063DOI Listing
February 2019

Dissolution, regeneration and characterization of curdlan in the ionic liquid 1-ethyl-3-methylimidazolium acetate.

Int J Biol Macromol 2019 Feb 13. Epub 2019 Feb 13.

Institute of Food Science and Technology, Chinese Academy of Agriculture Sciences, Beijing 100193, China. Electronic address:

In this work, a novel green solvent based on the ionic liquid (IL) 1-ethyl-3-methylimidazolium acetate (EmimAc) with a superior dissolving ability to biomacromolecules was utilized to boost solubility of water-insoluble curdlan. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), circular dichroism (CD), and nuclear magnetic resonance (NMR) were used to characterize the structural changes of curdlan before and after regeneration. Thermal decomposition property of curdlan was also investigated using thermal gravimetric analysis (TGA). Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.223DOI Listing
February 2019

Improvement of structural stability and functional efficiency of chaperonin GroEL mediated by mixed salt.

Int J Biol Macromol 2019 Feb 13;129:792-798. Epub 2019 Feb 13.

Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, India. Electronic address:

GroEL is the most commonly used chaperonin protein for both in-vitro refolding of aggregating proteins as well as in-vivo solubilization of over-expressed aggregation-prone proteins of therapeutic and biotechnological applications. But sometimes the stress conditions like heat and a load of over-expressed/unfolded/misfolded proteins lead to a decrease in structural stability and functional efficiency of GroEL, which results in less recovery of substrate protein through the chaperone-mediated refolding process. So, to amend it, we have been able to optimize physicochemical conditions utilizing a cumulation of (NH)SO/MgCl in the buffer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193011
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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.069DOI Listing
February 2019
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Chitosan nanopolymers: An overview of drug delivery against cancer.

Int J Biol Macromol 2019 Feb 13. Epub 2019 Feb 13.

Innovative Green Product Synthesis and Renewable Environment Development Research Group, Faculty of Environment and Labour Safety, Ton Duc Thang University, Ho Chi Minh City, Viet Nam. Electronic address:

Cancer is becoming a major reason for death troll worldwide due to the difficulty in finding an efficient, cost effective and target specific method of treatment or diagnosis. The variety of cancer therapy used in the present scenario have painful side effect, low effectiveness and high cost, which is a major drawback of the available therapies. Apart from the conventional cancer therapy, nanotechnology has grown extremely towards treating cancer. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.060DOI Listing
February 2019
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Preparation of chitosan coated zinc oxide nanocomposite for enhanced antibacterial and photocatalytic activity: As a bionanocomposite.

Int J Biol Macromol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biotechnology, Kongunadu Arts and Science College, Coimbatore 641029, Tamilnadu, India. Electronic address:

The surface coating of metal oxide nanoparticles using biopolymer chitosan has evolved to become an important area of polymer nanotechnology. Herein, we report the preparation of chitosan coated zinc oxide (CS-ZnO) nanocomposite for the first time by a green chemistry approach using bioflavonoid rutin. The formation of CS-ZnO nanocomposite was preliminarily confirmed by color change and UV-Visible spectroscopy. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.061DOI Listing
February 2019
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Effect of chitosan molecular weight on anti-inflammatory activity in the RAW 264.7 macrophage model.

Int J Biol Macromol 2019 Feb 13. Epub 2019 Feb 13.

Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan, ROC; Center for Marine Bioenvironment and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan, ROC. Electronic address:

Chitosan (300 kDa) was degraded by cellulase to chitosans with molecular weights (MWs) of 156, 72, 7.1, and 3.3 kDa and a chitooligosaccharide mixture (COS). Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.066DOI Listing
February 2019

H NMR characterization of chitin tetrasaccharide in binary HO:DMSO solution: Evidence for anomeric end-effect propagation.

Int J Biol Macromol 2019 Feb 13;129:744-749. Epub 2019 Feb 13.

Department of Chemistry, University of California - Riverside, Riverside, CA 92521, United States. Electronic address:

Chitin oligosaccharides, composed of homogeneous β(1 → 4)-linked N-acetyl-D-glucosamine (GlcNAc) sequences, is a well-known elicitor of plant immune defense, and also occur as structural elements of chitosan and nodulation (Nod) factor. Detailed microstructure characterization is required for understanding the function mode of these bioactive molecules. Herein, experimental conditions for detection and elucidation of the H NMR resonances of amide groups in chitin oligosaccharides are presented. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.062DOI Listing
February 2019
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Tuning physicochemical and biological properties of chitosan through complexation with transition metal ions.

Int J Biol Macromol 2019 Feb 14;129:645-652. Epub 2019 Feb 14.

Faculty of Chemical Engineering and Technology, University of Zagreb, HR-10001 Zagreb, Marulićev trg 19, p.p.177, Croatia. Electronic address:

The synthesis of biologically active scaffolds is focused on the design of cell-sensitive surface by applying cell-adhesive proteins or bioceramic micro (nano) particles. The emerging new strategy for manipulating the biological properties lies in the modification by trace metals found in the living organism. In this work, we have prepared biocompatible chitosan hydrogels modified by copper (II) and zinc (II) ions through complexation interactions. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.075DOI Listing
February 2019