484,378 results match your criteria International Journal of Biological Macromolecules [Journal]


Capsular polysaccharide in Mycoplasma mycoides is a virulence factor.

J Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

J. Craig Venter Institute, Rockville, MD USA.

Capsular polysaccharides have been confirmed to be an important virulence trait in many different Gram-positive and Gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals. In this study, goats were infected with the caprine pathogen Mycoplasma mycoides subsp. Read More

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December 2018

Role of electronic patient reported safety incidents in improving patient safety and care.

Int J Qual Health Care 2018 Dec 12. Epub 2018 Dec 12.

Graduate Institute of Bioinformatics, Taipei Medical University, Taipei, Taiwan.

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December 2018

University athletes and changes in cardiac geometry: insight from the 2015 Gwangju Summer Universiade.

Eur Heart J Cardiovasc Imaging 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiovascular Medicine, Chonnam National University Hospital, 42 Jebong-ro, Dong-gu, Gwangju, Korea.

Aims: There is a paucity of data regarding the changes of cardiac geometry in highly trained international and multiracial university athletes. We aimed to investigate the incidence of structural cardiac abnormalities and changes of cardiac geometry in highly trained university athletes.

Methods And Results: Comprehensive echocardiographic studies were performed in 1185 university athletes through the Check-up Your Heart Program during the 2015 Gwangju Summer Universiade. Read More

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December 2018

KDM5D-mediated H3K4 demethylation is required for sexually dimorphic gene expression in mouse embryonic fibroblasts.

J Biochem 2018 Dec 12. Epub 2018 Dec 12.

Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan.

Males and females share the same genetic code, but gene expression profile often displays differences between two sexes. Mouse embryonic fibroblasts (MEFs) have been used to experiment as a useful tool to test gene function. They have also been characterized by gender-based differences in expressed genes such as Y-linked Sry or X-linked Hprt. Read More

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December 2018

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.

Authors:
Naomi Walsh Han Zhang Paula L Hyland Qi Yang Evelina Mocci Mingfeng Zhang Erica J Childs Irene Collins Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Paul Brennan Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Michael Goggins Gary E Goodman Phyllis J Goodman Rayjean J Hung Charles Kooperberg Robert C Kurtz Núria Malats Loic LeMarchand Rachel E Neale Sara H Olson Ghislaine Scelo Xiao O Shu Stephen K Van Den Eeden Kala Visvanathan Emily White Wei Zheng Demetrius Albanes Gabriella Andreotti Ana Babic William R Bamlet Sonja I Berndt Ayelet Borgida Marie-Christine Boutron-Ruault Lauren Brais Paul Brennan Bas Bueno-de-Mesquita Julie Buring Kari G Chaffee Stephen Chanock Sean Cleary Michelle Cotterchio Lenka Foretova Charles Fuchs J Michael M Gaziano Edward Giovannucci Michael Goggins Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Vladimir Janout Eric A Klein Robert C Kurtz Daniel Laheru I-Min Lee Lingeng Lu Núria Malats Satu Mannisto Roger L Milne Ann L Oberg Irene Orlow Alpa V Patel Ulrike Peters Miquel Porta Francisco X Real Nathaniel Rothman Howard D Sesso Gianluca Severi Debra Silverman Oliver Strobel Malin Sund Mark D Thornquist Geoffrey S Tobias Jean Wactawski-Wende Nick Wareham Elisabete Weiderpass Nicolas Wentzensen William Wheeler Herbert Yu Anne Zeleniuch-Jacquotte Peter Kraft Donghui Li Eric J Jacobs Gloria M Petersen Brian M Wolpin Harvey A Risch Laufey T Amundadottir Kai Yu Alison P Klein Rachael Z Stolzenberg-Solomon

J Natl Cancer Inst 2018 Dec 12. Epub 2018 Dec 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes.

Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. Read More

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December 2018

Predicting Ames Mutagenicity Using Conformal Prediction in the Ames/QSAR International Challenge Project.

Mutagenesis 2018 Dec 12. Epub 2018 Dec 12.

Computer Learning Research Centre, Royal Holloway, University of London Egham, Surrey, UK.

Valid and predictive models for classifying Ames mutagenicity have been developed using conformal prediction. The models are Random Forest models using signature molecular descriptors. The investigation indicates, on excluding not-strongly mutagenic compounds (class B), that the validity for mutagenic compounds is increased for the predictions based on both public and the Division of Genetics and Mutagenesis, National Institute of Health Sciences of Japan (DGM/NIHS) data while less so when using only the latter data source. Read More

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December 2018

TNM classification of malignant tumors (Breast Cancer Study Group).

Jpn J Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

The eighth editions of the primary tumor, lymph node and metastasis classifications for breast cancer issued by the American Joint Commission of Cancer and the Union for International Cancer Control were revised in 2017. The major change made by the American Joint Commission of Cancer is to incorporate biological factors such as estrogen and progesterone receptor, human epidermal growth factor receptor 2, histological grade and multigene prognostic assays, into the staging system. Tumor biomarkers and low recurrence scores confirmed by multigene prognostic assays change the staging. Read More

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December 2018

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.

Cell Rep 2018 Dec;25(11):3047-3058.e4

Biozentrum, University of Basel, 4056 Basel, Switzerland. Electronic address:

Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4). We report that syrosingopine, an anti-hypertensive drug, is a dual MCT1 and MCT4 inhibitor (with 60-fold higher potency on MCT4) that prevents lactate and H efflux. Syrosingopine elicits synthetic lethality with metformin, an inhibitor of mitochondrial NADH dehydrogenase. Read More

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December 2018

The know-do gap in sick child care in Ethiopia.

PLoS One 2018 12;13(12):e0208898. Epub 2018 Dec 12.

International Institue for Primary Health Care- Ethiopia, Addis Ababa, Ethiopia.

Background: While health care provider knowledge is a commonly used measure for process quality of care, evidence demonstrates that providers don't always perform as much as they know. We describe this know-do gap for malaria care for sick children among providers in Ethiopia and examine what may predict this gap.

Methods: We use a 2014 nationally-representative survey of Ethiopian providers that includes clinical knowledge vignettes of malaria care and observations of care provided to children in facilities. Read More

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December 2018

Adherence to quality of care measurements among 58,182 patients with new onset diabetes and its association with mortality.

PLoS One 2018 12;13(12):e0208539. Epub 2018 Dec 12.

The Department of Family Medicine, The Sackler Faculty of Medicine, University of Tel Aviv, Tel-Aviv, Israel.

Objectives: Disease registry for diabetes care encourages transparency and benchmarking of quality of care (QoC) measurements for all service providers and seems to improve diabetes care. This study evaluate changes over time in QoC measurement performance in a large diabetes registry among newly diagnosed diabetics and it association with mortality.

Methods: Retrospective cohort study of patients in a large health maintenance organization diabetes registry from years 2000 to 2013. Read More

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December 2018
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Physicochemical and microbiological characterization of the sensory deviation responsible for the origin of the special sherry wines "palo cortado" type.

PLoS One 2018 12;13(12):e0208330. Epub 2018 Dec 12.

Department of Chemical Engineering and Food Technology, Faculty of Sciences, University of Cadiz, Cadiz, Spain.

The aim of this study was to characterize the biochemical changes and microbiological processes involved in the sensory deviation of "sobretablas" wines during biological aging, which leads to the origin of special or rare "palo cortado" wines. Industrial trials of biological aging of "sobretablas" wines with the potential for the development of lactic acid bacteria (LAB) were performed to study this phenomenon. The results showed that sensory deviation was due to the development of malolactic fermentation (MLF) together with an attenuated aerobic metabolism of "flor" yeast. Read More

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December 2018
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Spiroergometric measurements under increased inspiratory oxygen concentration (FIO2)-Putting the Haldane transformation to the test.

PLoS One 2018 12;13(12):e0207648. Epub 2018 Dec 12.

Institute for Occupational and Maritime Medicine (ZfAM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Spiroergometric measurements of persons who require oxygen insufflation due to illness can be performed under conditions of increased inspiratory oxygen concentration (FIO2). This increase in FIO2, however, often leads to errors in the calculation of oxygen consumption ([Formula: see text]). These inconsistencies are due to the application of the Haldane Transformation (HT), an otherwise indispensable correction factor in the calculation of [Formula: see text] that becomes inaccurate at higher FIO2 concentrations. Read More

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December 2018

Usefulness of baseline statin therapy in non-obstructive coronary artery disease by coronary computed tomographic angiography: From the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) study.

PLoS One 2018 12;13(12):e0207194. Epub 2018 Dec 12.

Department of Radiology, NewYork-Presbyterian Hospital and the Weill Cornell Medical College, New York, New York, United States of America.

Background: The extent to which the presence and extent of subclinical atherosclerosis by coronary computed tomography angiography influences a potential mortality benefit of statin is unknown. We evaluated the relationship between statin therapy, mortality, and subclinical atherosclerosis.

Methods: In the CONFIRM study, patients with normal or non-obstructive plaque (<50% diameter stenosis) for whom data on baseline statin use was available were included. Read More

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December 2018

[Good practices and ethical principles: as necessary as ever].

Authors:
Lely Solari

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):306-309

Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú.

We are going through a moment in which acts of disregard to the ethics in the public function are being disclosed at all levels. It is important to know the codes of ethics and good practices of each of the functions performed. In the field of scientific publications, it is highly recommended that all researchers who wish to publish their studies get to know the good scientific practices and the basic ethical principles of publications in science. Read More

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December 2018

What Factors Predict the Risk of Proximal Junctional Failure in the Long Term, Demographic, Surgical or Radiographic? Results from a Time-Dependent ROC Curve.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY.

Study Design: Retrospective review of prospective multicenter database.

Objective: To identify an optimal set of factors predicting the risk of PJF while taking the time dependency of PJF and those factors into account.

Summary Of Background Data: Surgical correction of adult spinal deformity (ASD) can be complex and therefore, may come with high revision rates due to proximal junctional failure (PJF). Read More

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December 2018

Influence of Anastomotic Leak After Elective Colorectal Cancer Resection on Survival and Local Recurrence: A Propensity Score Analysis.

Dis Colon Rectum 2018 Nov 28. Epub 2018 Nov 28.

Background: The occurrence of anastomotic leakage is still a life-threatening complication for patients after colorectal surgery. In literature not only an impact on the short-term outcome but also on long-term survival and local recurrence of colorectal cancer patients is discussed.

Objective: This study aimed to investigate the impact of anastomotic leakage on long-term survival and local recurrence. Read More

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November 2018
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Hemodynamic effects of the dipeptidyl peptidase-4 inhibitor linagliptin with renin-angiotensin system inhibitors in type 2 diabetic patients with albuminuria.

J Hypertens 2018 Dec 11. Epub 2018 Dec 11.

Boehringer Ingelheim International GmbH, Ingelheim.

Objective: Concomitant treatment with angiotensin-converting enzyme (ACE) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors is increasingly common. Pharmacological studies have suggested a potential adverse drug interaction between ACE inhibitors and DPP-4 inhibitors resulting in unfavorable hemodynamic changes; very few studies have examined such an interaction between angiotensin II receptor blockers (ARBs) and DPP-4 inhibitors. We investigated blood pressure (BP) and heart rate (HR) during treatment with the DPP-4 inhibitor linagliptin in individuals receiving either ACE inhibitors or ARBs in the MARLINA-T2D trial. Read More

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December 2018

The Effectiveness of an International Cleft Mission Model in Asia: An Update.

Ann Plast Surg 2019 Jan;82(1S Suppl 1):S23-S28

Plastic and Reconstructive Surgery and Craniofacial Research Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.

Background: Cleft lip/palate is a congenital craniofacial anomaly affecting patients physically and psychosocially and has contributed to the global burden of surgical disease, especially in underprivileged areas. For 20 years, Noordhoff Craniofacial Foundation (NCF) and the Chang Gung Craniofacial Center (CGCFC) have carried out missions to these areas. Rather than implementing short-term missions that lack proper follow-up care, the team has provided an effective, long-term, and multidisciplinary approach for the treatment of patients with cleft lip/palate. Read More

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January 2019
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Perceptions of a Good Death in Children with Life-Shortening Conditions: An Integrative Review.

J Palliat Med 2018 Dec 11. Epub 2018 Dec 11.

2 International Observatory on End of Life Care, Lancaster University , Lancaster, United Kingdom .

Background: For children with life-shortening illness, achieving a "good death" can be a tacit goal. There is little understanding of how different stakeholders perceive what a "good death" might be.

Objective: To review empirical literature to construct an understanding of a "good death" for children with life-shortening conditions. Read More

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December 2018
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Advancements in Life Cycle Human Exposure and Toxicity Characterization.

Environ Health Perspect 2018 Dec;126(12):125001

16 School of Public Health, University of California , Berkeley, California, USA.

Background: The Life Cycle Initiative, hosted at the United Nations Environment Programme, selected human toxicity impacts from exposure to chemical substances as an impact category that requires global guidance to overcome current assessment challenges. The initiative leadership established the Human Toxicity Task Force to develop guidance on assessing human exposure and toxicity impacts. Based on input gathered at three workshops addressing the main current scientific challenges and questions, the task force built a roadmap for advancing human toxicity characterization, primarily for use in life cycle impact assessment (LCIA). Read More

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December 2018
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Conclusions of the digital health hub of the Transform Africa Summit (2018): strong government leadership and public-private-partnerships are key prerequisites for sustainable scale up of digital health in Africa.

BMC Proc 2018 15;12(Suppl 11):17. Epub 2018 Aug 15.

WHO Country Office, Kigali, Rwanda.

Background: The use of digital technologies to improve access to health is gaining momentum in Africa. This is more pertinent with the increasing penetration of mobile phone technology and internet use, and calls for innovative strategies to support implementation of the health-related Sustainable Development Goals and Universal Health Coverage on the continent. However, the huge potential benefits of digital health to advance health services delivery in Africa is yet to be fully harnessed due to critical challenges such as proliferation of pilot projects, poor coordination, inadequate preparedness of the African health workforce for digital health, lack of interoperability and inadequate sustainable financing, among others. Read More

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[Dark personality traits at work].

Psychiatr Hung 2018 ;33(4):359-373

Pecsi Tudomanyegyetem, Pszichologia Intezet, Pecs, Hungary, E-mail:

Nowadays there has been an increase of scientific interest related to the dark triad of personality: Machiavellianism, subclinical narcissism and subclinical psychopathy. In the last two decades several studies were published about the work related correlates of the dark personality traits. The aim of the current paper is to summarize and review these international and Hungarian research findings. Read More

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January 2018

ICTV Virus Taxonomy Profile: Tristromaviridae.

J Gen Virol 2018 Dec 12. Epub 2018 Dec 12.

1​Department of Microbiology, Institut Pasteur, 25 Rue du Dr. Roux, 75015 Paris, France.

Tristromaviridae is a family of viruses with linear, double-stranded DNA genomes of 16-18 kbp. The flexible, filamentous virions (400±20 nm×30±3 nm) consist of an envelope and an inner core constructed from two structural units: a rod-shaped helical nucleocapsid and a nucleocapsid-encompassing matrix protein layer. Tristromaviruses are lytic and infect hyperthermophilic archaea of the order Thermoproteales. Read More

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December 2018

An update on the clinical consequences of polypharmacy in older adults: a narrative review.

Expert Opin Drug Saf 2018 Dec 12:1-12. Epub 2018 Dec 12.

a Aging Research Center, Department of Neurobiology , Care Sciences and Society, Karolinska Institutet & Stockholm University , Stockholm , Sweden.

Introduction: Polypharmacy, the use of multiple medications by one individual, is increasingly common among older adults. Caring for the growing number of older people with complex drug regimens and multimorbidity presents an important challenge in the coming years. Areas covered: This article reviews the international trends in the prevalence of polypharmacy, summarizes the results from previous reviews on polypharmacy and negative health outcomes, and updates a previous review on the clinical consequences of polypharmacy by focusing on studies published after 2013. Read More

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December 2018

Efficacy and safety of pulsed intravenous methylprednisolone in early active thyroid eye disease.

Orbit 2018 Dec 12:1-8. Epub 2018 Dec 12.

a Division of Orbit & Oculofacial Surgery, Department of Ophthalmology , National University Hospital , Singapore , Singapore.

Introduction: The mainstay of therapy for active inflammatory phase of thyroid eye disease (TED) is immunosuppression. Patients in our centre with early active TED are treated with pulsed intravenous methylprednisolone (IVMP). Two different protocols are offered in our centre: High dose (1g/day for 3 days, monthly for 6 months), or EUGOGO protocol (500 mg weekly for six weeks, followed by 250 mg weekly for the next 6 weeks). Read More

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December 2018

Visible-Light-Promoted Transition-Metal-Free Phosphinylation of Heteroaryl Halides in the Presence of Potassium tert-Butoxide.

Org Lett 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Synthetic Chemistry, and Department of Chemistry , The University of Hong Kong , Pokfulam Road, Hong Kong , China.

A novel visible-light-promoted C-P bond formation reaction in the absence of both transition metal and photoredox catalysts is disclosed. By employing easily available and inexpensive heteroaryl chlorides/bromides as substrates, a variety of heteroaryl phosphine oxides were obtained in moderate to good yields. This strategy provides a simple and efficient route to heteroaryl phosphine oxides. Read More

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December 2018

Structural Revision of Macropodumine A and Structure of 2-Deoxymacropodumine A, Daphniphyllum Alkaloids with 11-Membered Macrolactone Rings.

J Nat Prod 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences , Kunming 650201 , People's Republic of China.

An unusual Daphniphyllum alkaloid, 2-deoxymacropodumine A (1), possessing an 11-membered macrolactone ring, was obtained from an extract of the stems of Daphniphyllum angustifolium. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic methods and chemical calculations. Based on a comparison of the experimental and calculated NMR data, the structure of macropodumine A (2'), an analogue of 1, was also revised. Read More

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December 2018
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[Contributions of master in international health & nutrition policies alumni to African development.]

Sante Publique 2018 July August;30(4):535-544

Objectives: This study aims to analyze how graduates, coming from low income Francophone countries, of the Master in International Health and Nutrition Policies program at the Senghor University are a new human capital bringing an original contribution to the global development of African communities.

Methods: A secondary analysis of qualitative findings responded to the research question about the evidences of the impact of this new human capital over the community development of countries where the graduates worked. Findings also revealed graduates' potential to contribute to future endeavors in global health. Read More

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December 2018

TEMPORAL COMPARISON OF WHEEZING PREVALENCE IN THE FIRST YEAR OF LIFE IN SÃO PAULO: INTERNATIONAL STUDY OF WHEEZING IN INFANTS.

Rev Paul Pediatr 2018 Oct-Dec;36(4):445-450

Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Objective: To assess the prevalence and severity of wheezing in the first year of life of infants, using the standardized protocol of the Estudio Internacional de Sibilancias en Lactantes- phase 3, and compare the values obtained with those found in phase 1, conducted at the same center.

Methods: Between 2009 and 2010, parents and guardians of infants answered the written questionnaire of the Estudio Internacional de Sibilancias en Lactantes - phase 3, and its results were compared to those of phase 1, performed between 2005 and 2006. We divided the infants into wheezing and non-wheezing. Read More

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ADVANCES IN THERAPEUTIC ENDOSCOPY.

Arq Gastroenterol 2018 Jul-Sep;55(3):201

Endovitta Instituto, São Paulo, SP, Brasil.

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December 2018

Nursing students' perception about humanized care: an integrative review.

Rev Bras Enferm 2018 ;71(suppl 6):2800-2807

Universidade Federal Fluminense, School of Nursing. Niterói, Rio de Janeiro, Brazil.

Objective: To analyze the productions of knowledge about the students' perception of humanized care.

Method: Study of bibliographical revision of the integrative type. The databases Pubmed, Lilacs, Cuiden and the SciELO virtual library were chosen for selection in October 2017, using the health descriptors "Students, Nursing", "Perception" and "Humanization of assistance", in the languages Portuguese, English and Spanish. Read More

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January 2018

[Insufficient levels of physical activity of adolescents associated with sociodemographic, environmental and school factors].

Cien Saude Colet 2018 Dec;23(12):4277-4288

Centro de Ciências da Saúde e do Esporte, Universidade do Estado de Santa Catarina. R. Paschoal Simoni 358, Coqueiros. 88080-350 Florianópolis SC Brasil.

This study investigated the associations between the level of physical activity with sociodemographic, environmental and academic factors of adolescents. Two thousand five hundred and forty-five adolescents aged between 14 and 18 from Florianópolis and neighboring cities participated in this study. The short version of the International Physical Activity Questionnaire (IPAQ) was used. Read More

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December 2018

Technical Note on Using the Movement Velocity to Estimate the Relative Load in Resistance Exercises - Letter to the Editor.

Sports Med Int Open 2018 Jan 29;2(1):E16. Epub 2017 Nov 29.

Clinical Research Institute, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

The studies by Sanchez-Medina et al. ( , (02), E80-E88. 2017) and Gonzalez-Badillo and Sanchez-Medina ( 31 347-52. Read More

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January 2018

Tracking significant modules and key genes for esophageal squamous cell carcinoma based on differential modules.

J Cancer Res Ther 2018 Dec;14(Supplement):S1135-S1140

Department of General Surgery, Peking University International Hospital, Beijing 100026, China.

Background: The exact molecular mechanism of esophageal squamous cell carcinoma (ESCC) is still unknown, and the prognosis of ESCC has not been significantly improved.

Objective: To understand the molecular mechanism of ESCC, differential modules (DMs) and key genes were identified through conducting analysis on the differential co-expression network (DCN) based on the gene expression profiles of ESCC and protein-protein interaction (PPI) data.

Materials And Methods: First, gene expression profiles of ESCC and PPI data recruiting and preprocessing were conducted; then, a DCN was constructed based on the gene co-expression and gene differential expression in ESCC; in the following, candidate DMs were mined from DCN through a systemic module searching strategy, and significance analysis was performed on candidate DMs to identify DMs; moreover, significant genes contained in the DMs were analyzed to identify the underlying biomarkers for ESCC. Read More

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December 2018

Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis.

Neural Regen Res 2019 Mar;14(3):532-541

Department of Orthopedics, Tianjin Medical University General Hospital; International Science and Technology Cooperation Base of Spinal Cord Injury; Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China.

Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. Read More

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Sodium valproate suppresses abnormal neurogenesis induced by convulsive status epilepticus.

Neural Regen Res 2019 Mar;14(3):480-484

Department of Neurology, Children's Hospital of Chongqing Medical University; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; Key Laboratory of Pediatrics in Chongqing, Chongqing, China.

Status epilepticus has been shown to activate the proliferation of neural stem cells in the hippocampus of the brain, while also causing a large amount of neuronal death, especially in the subgranular zone of the dentate gyrus and the subventricular zone. Simultaneously, proliferating stem cells tend to migrate to areas with obvious damage. Our previous studies have clearly confirmed the effect of sodium valproate on cognitive function in rats with convulsive status epilepticus. Read More

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Prognostic factors and patterns of failure in advanced stage Hodgkin lymphoma treated with combined modality therapy.

Radiother Oncol 2018 Dec 6;129(3):507-512. Epub 2018 Jul 6.

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, USA. Electronic address:

Background And Purpose: The role of irradiation to non-bulky and bulky sites of disease in advanced stage Hodgkin lymphoma is controversial. We aimed to review the long-term outcomes of patients treated with combined modality therapy to clarify the role of consolidative radiotherapy.

Materials And Methods: Patients with stage III or IV Hodgkin lymphoma treated with Stanford V chemotherapy and consolidative radiotherapy to initial sites of disease ≥5 cm were analyzed retrospectively to determine patient outcomes, patterns of failure, and factors associated with treatment failure. Read More

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December 2018

Heart Transplantation Cost Composition in Brazil: A Patient-Level Microcosting Analysis and Comparison With International Data.

J Card Fail 2018 Dec 26;24(12):860-863. Epub 2018 Oct 26.

Heart Transplant Program, Division of Cardiology, Hospital de Clínicas de Porto Alegre, Brazil; National Health Technology Assessment Institute, National Council for Scientific and Technological Development (CNPq), Brazil. Electronic address:

Background: Advanced heart failure (HF) therapies, such as heart transplantation, are resource intensive and costly. In Brazil, only one-fifth of the estimated population need is fulfilled. We examined cost expenditures of heart transplants in a public institution in Brazil. Read More

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December 2018

Cystathionine β-synthase induces multidrug resistance and metastasis in hepatocellular carcinoma.

Curr Mol Med 2018 Dec 11. Epub 2018 Dec 11.

College of Pharmacy, Joint International Research Laboratory of Food & Medicine,Henan University, Kaifeng 475004, Henan Province. China.

Objective: This study aims to analyze whether Cystathionine β-synthase (CBS) plays roles in hepatocellular carcinoma (HCC) drug resistance.

Methods: MTS assay was used to detect the effect of chemotherapeutic drugs doxorubicin (DOX) and sunitinib on HCC cell viability and cell growth. Intracellular doxorubicin accumulation assay was performed to evaluate the sensitivity of DOX and sunitinib in HCC cells and the function of multidrug resistance-associated protein P-glycoprotein (P-gp). Read More

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December 2018

Detection of Autoantibodies by Indirect Immunofluorescence Cytochemistry on Hep-2 Cells.

Methods Mol Biol 2019 ;1901:19-46

Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

Indirect immunofluorescence assay (IFA) has been used for detection of autoantibodies against cellular antigens for more than 50 years. Originally using rodent tissue as substrate, the method was optimized by using the human immortal HEp-2 cell line derived from a larynx epidermal carcinoma. The HEp-2/IFA platform allows for optimal visualization of several cellular domains recognized by autoantibodies in the samples being tested. Read More

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January 2019

A new decision tree for diagnosis of osteoarthritis in primary care: international consensus of experts.

Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.

Service de rééducation et réadaptation de l'appareil locomoteur et des pathologies du rachis, Laboratoire de Pharmacologie, Toxicologie et Signalisation Cellulaire, Univ. Paris Descartes, PRES Sorbonne Paris Cité, Hôpital Cochin, Assistance Publique -Hôpitaux de Paris, INSERM UMR-S 1124, UFR Biomédicale des Saints Pères, Paris, France.

Background And Aims: Although osteoarthritis (OA) is managed mainly in primary care, general practitioners (GPs) are not always trained in its diagnosis, which leads to diagnostic delays, unnecessary resource utilization, and suboptimal patient outcomes.

Methods: To address this situation, an International Rheumatologic Board (IRB) of 8 experts from 3 continents developed guidelines for the diagnosis of OA in primary care. The focus was three major topologies: hip, knee, and hand/finger OA. Read More

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December 2018

Domestic and International Shipping of Biospecimens.

Methods Mol Biol 2019 ;1897:433-443

Division of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

The packaging and shipment of biospecimens is a multistep process for which a distinct set of regulations needs to be followed, depending on whether a biospecimen is shipped domestically or internationally and whether the shipment contains hazardous materials. Shipments may be delayed if these regulations are not followed. Once learned, the process is straightforward. Read More

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January 2019

ATP Synthase Subunit Beta Immunostaining is Reduced in the Sclerotic Hippocampus of Epilepsy Patients.

Cell Mol Neurobiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Anatomical Pathology, School of Medical Sciences, University of Campinas (UNICAMP), Av. Tessália Vieira de Camargo, 126, Campinas, SP, CEP 13083-887, Brazil.

Epilepsy is a common disease presenting with recurrent seizures. Hippocampal sclerosis (HS) is the commonest histopathological alteration in patients with temporal lobe epilepsy (TLE) undergoing surgery. HS physiopathogenesis is debatable. Read More

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December 2018

A Review on Ingested Cyanide: Risks, Clinical Presentation, Diagnostics, and Treatment Challenges.

J Med Toxicol 2018 Dec 11. Epub 2018 Dec 11.

Department of Emergency Medicine and Toxicology, University of Colorado School of Medicine, 12700 E. 19th Ave., Aurora, CO, 80045, USA.

Cyanide, a metabolic poison, is a rising chemial threat and ingestion is the most common route of exposure. Terrorist organizations have threatened to attack the USA and international food and water supplies. The toxicokinetics and toxicodynamics of oral cyanide are unique, resulting in high-dose exposures, severe symptoms, and slower onset of symptoms. Read More

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December 2018

Genotyping-by-sequencing based genetic mapping reveals large number of epistatic interactions for stem rot resistance in groundnut.

Theor Appl Genet 2018 Dec 11. Epub 2018 Dec 11.

ICAR-Directorate of Groundnut Research (ICAR-DGR), Junagadh, 362001, India.

Key Message: Genetic mapping identified large number of epistatic interactions indicating the complex genetic architecture for stem rot disease resistance. Groundnut (Arachis hypogaea) is an important global crop commodity and serves as a major source of cooking oil, diverse confectionery preparations and livestock feed. Stem rot disease caused by Sclerotium rolfsii is the most devastating disease of groundnut and can cause up to 100% yield loss. Read More

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December 2018

Technical variations and feasibility of transanal ileal pouch-anal anastomosis for ulcerative colitis and inflammatory bowel disease unclassified across continents.

Tech Coloproctol 2018 Dec 11. Epub 2018 Dec 11.

Cedars Sinai Medical Center, 8737 Beverly Blvd. Suite 101, Los Angeles, CA, 90048, USA.

Purpose: Initial reports of transanal ileal pouch-anal anastomosis (taIPAA) suggest safety and feasibility compared with transabdominal IPAA. The purpose of this study was to evaluate differences in technique and results of taIPAA in three centers performing taIPAA across two continents.

Methods: Prospective IPAA registries from three institutions in the US and Europe were queried for patients undergoing taIPAA. Read More

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December 2018

Habitat use of sympatric prey suggests divergent anti-predator responses to recolonizing gray wolves.

Oecologia 2018 Dec 11. Epub 2018 Dec 11.

School of Environmental and Forest Sciences, University of Washington, Seattle, WA, USA.

The non-consumptive effects of predators on prey are now widely recognized, but the need remains for studies identifying the factors that determine how particular prey species respond behaviorally when threatened with predation. We took advantage of ongoing gray wolf (Canis lupus) recolonization in eastern Washington, USA, to contrast habitat use of two sympatric prey species-mule (Odocoileus hemionus) and white-tailed (O. virginianus) deer-at sites with and without established wolf packs. Read More

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December 2018

Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies.

Osteoporos Int 2018 Dec 12. Epub 2018 Dec 12.

Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Hsing St., Taipei, 110, Taiwan.

We performed a meta-analysis of relevant studies to quantify the magnitude of the association between proton pump inhibitors (PPIs) and risk of hip fracture. Patients with PPIs had a greater risk of hip fracture than those without PPI therapy (RR 1.20, 95% CI 1. Read More

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December 2018

International Space Station conditions alter genomics, proteomics, and metabolomics in Aspergillus nidulans.

Appl Microbiol Biotechnol 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Rm 406A, Los Angeles, CA, 90089-9121, USA.

The first global genomic, proteomic, and secondary metabolomic characterization of the filamentous fungus Aspergillus nidulans following growth onboard the International Space Station (ISS) is reported. The investigation included the A. nidulans wild-type and three mutant strains, two of which were genetically engineered to enhance secondary metabolite production. Read More

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December 2018

Use of benzodiazepines and z-drugs not compliant with guidelines and associated factors: a population-based study.

Eur Arch Psychiatry Clin Neurosci 2018 Dec 11. Epub 2018 Dec 11.

Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, University of Bordeaux, 33000, Bordeaux, France.

Benzodiazepines and z-drugs are primarily indicated for the treatment of sleep disorders and anxiety symptoms. Their frequent long-term use contrasts with the international guidelines that limit treatment duration to a maximum of 4 weeks. The objective of this study was to assess the frequency of their use that was not in accordance with guidelines in the French general population between 2007 and 2012 and associated characteristics. Read More

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December 2018