3,243 results match your criteria International Journal of Biochemistry & Cell Biology [Journal]


Multibandgap quantum dot ensembles for solar-matched infrared energy harvesting.

Nat Commun 2018 10 1;9(1):4003. Epub 2018 Oct 1.

Department of Electrical and Computer Engineering, University of Toronto, 10 King's College Road, Toronto, ON, M5S 3G4, Canada.

As crystalline silicon solar cells approach in efficiency their theoretical limit, strategies are being developed to achieve efficient infrared energy harvesting to augment silicon using solar photons from beyond its 1100 nm absorption edge. Herein we report a strategy that uses multi-bandgap lead sulfide colloidal quantum dot (CQD) ensembles to maximize short-circuit current and open-circuit voltage simultaneously. We engineer the density of states to achieve simultaneously a large quasi-Fermi level splitting and a tailored optical response that matches the infrared solar spectrum. Read More

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http://dx.doi.org/10.1038/s41467-018-06342-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167381PMC
October 2018
30 Reads
10.742 Impact Factor

The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution.

Elife 2018 08 15;7. Epub 2018 Aug 15.

Department of Biochemistry and Molecular Biology, Faculty of Medicine, Life Sciences Institute, University of British Columbia, Vancouver, Canada.

Membrane proteins are difficult to work with due to their insolubility in aqueous solution and quite often their poor stability in detergent micelles. Here, we present the peptidisc for their facile capture into water-soluble particles. Unlike the nanodisc, which requires scaffold proteins of different lengths and precise amounts of matching lipids, reconstitution of detergent solubilized proteins in peptidisc only requires a short amphipathic bi-helical peptide (NSP) and no extra lipids. Read More

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http://dx.doi.org/10.7554/eLife.34085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093710PMC
August 2018
38 Reads
8.520 Impact Factor

Corrigendum to 'specific changes in the proteomic pattern produced by the BRCA1-Ser1841Asn missense mutation' [International Journal of Biochemistry and Cell Biology (2007) 220-226].

Int J Biochem Cell Biol 2017 07 25;88:236-237. Epub 2017 Mar 25.

Dipartimento di Medicina Sperimentale e Clinica "G. Salvatore", Universit'a degli Studi di Catanzaro "Magna Græcia", Viale Europa Campus Universitario Germaneto, 88100 Catanzaro, Italy.

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http://dx.doi.org/10.1016/j.biocel.2017.03.006DOI Listing
July 2017
6 Reads

Corrigendum to 'Mitofusin 2 ameliorates hypoxia-induced apoptosis via mitochondrial function and signaling pathways title of article' [International Journal of Biochemistry and Cell Biology 69 (2015) 29-40].

Int J Biochem Cell Biol 2016 04 29;73:137. Epub 2016 Jan 29.

Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.01.014DOI Listing
April 2016
18 Reads

Energy metabolism disorders in rare and common diseases. Toward bioenergetic modulation therapy and the training of a new generation of European scientists.

Int J Biochem Cell Biol 2015 Jun 14;63:2-9. Epub 2015 Jan 14.

The International Journal of Biochemistry and Cell Biology, EA4576 MRGM, University of Bordeaux, CHU Pellegrin, Place Amélie-Raba Léon, 33076 Bordeaux Cedex, France. Electronic address:

Energy metabolism alterations are found in a large number of rare and common diseases of genetic or environmental origin. The number of patients that could benefit from bioenergetic modulation therapy (BIOMET) is therefore very important and includes individuals with pathologies as diverse as mitochondrial diseases, acute coronary syndrome, chronic kidney disease, asthma or even cancer. Although, the alteration of energy metabolism is disease specific and sometimes patient specific, the strategies for BIOMET could be common and target a series of bioenergetic regulatory mechanisms discussed in this article. Read More

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http://dx.doi.org/10.1016/j.biocel.2015.01.003DOI Listing
June 2015
12 Reads

Vitiligo: a complex disease and a complex approach.

Mol Cytogenet 2014 21;7(Suppl 1 Proceedings of the International Conference on Human):I57. Epub 2014 Jan 21.

Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, India.

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http://dx.doi.org/10.1186/1755-8166-7-S1-I57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044533PMC
June 2014
6 Reads
3 Citations
2.662 Impact Factor

Genetics of cardiovascular disorders: influence of maternal nutrition.

Mol Cytogenet 2014 21;7(Suppl 1 Proceedings of the International Conference on Human):I5. Epub 2014 Jan 21.

Department of Biochemistry, Memorial University of Newfoundland, St. John's, Canada.

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http://dx.doi.org/10.1186/1755-8166-7-S1-I5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044390PMC
June 2014
3 Reads

Perspective of stem cell research & therapy in diabetes.

Authors:
Sarita Gupta

Mol Cytogenet 2014 21;7(Suppl 1 Proceedings of the International Conference on Human):I61. Epub 2014 Jan 21.

Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, India.

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http://dx.doi.org/10.1186/1755-8166-7-S1-I61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042335PMC
June 2014
2 Reads

The low dose gamma ionising radiation impact upon cooperativity of androgen-specific proteins.

J Environ Radioact 2014 Jan 5;127:182-90. Epub 2013 Mar 5.

Lab. of Biochemistry, Institute of Radiobiology, National Academy of Sciences of Belarus, Feduninskogo 4, Gomel 246007, Belarus.

The paper deals with effects of the ionising radiation (γ-IR, 0.5 Gy) upon serum testosterone (T), characteristics of testosterone-binding globulin (TeBG) and androgen receptor (AR) in parallel with observation of androgen (A) responsive enzyme activity - hexokinase (HK). The interdependence or relationships of T-levels with parameters of the proteins that provide androgenic regulation are consequently analyzed in post-IR dynamics. Read More

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http://dx.doi.org/10.1016/j.jenvrad.2013.02.002DOI Listing
January 2014
2 Reads

The International Journal of Biochemistry & Cell Biology. Preface.

Int J Biochem Cell Biol 2011 Feb 15;43(2):172. Epub 2010 Sep 15.

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http://dx.doi.org/10.1016/j.biocel.2010.09.004DOI Listing
February 2011
2 Reads

WITHDRAWN: The nonstructural protein-1 of influenza virus A.

Int J Biochem Cell Biol 2008 Nov 1. Epub 2008 Nov 1.

Department of Haematology/Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiaotong University, Dongfang Road 1678, Shanghai, PR China.

This article has been retracted; please see Elsevier Policy on Article Withdrawal: http://www.elsevier.com/locate/withdrawalpolicy This article has been retracted at the request of the Editor-in-Chief of The International Journal of Biochemistry and Cell Biology, as the authors have plagiarised sections of several other papers that had been previously published (Hale et al. Read More

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http://dx.doi.org/10.1016/j.biocel.2008.10.016DOI Listing
November 2008
3 Reads

Corneal epithelial stem cells: deficiency and regulation.

Stem Cell Rev 2008 Sep 12;4(3):159-68. Epub 2008 Jul 12.

Cells for Sight Transplantation and Research Programme, Ocular Repair and Regeneration Biology Unit, Division of Pathology, UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK.

The corneal epithelium is continuously renewed by a population of stem cells that reside in the corneoscleral junction, otherwise known as the limbus. These limbal epithelial stem cells (LESC) are imperative for corneal maintenance with deficiencies leading to in-growth of conjunctival cells, neovascularisation of the corneal stroma and eventual corneal opacity and visual loss. One such disease that has traditionally been thought to be due to LESC deficiency is aniridia, a pan-ocular congenital eye disease due to mutations in the PAX6 gene. Read More

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http://dx.doi.org/10.1007/s12015-008-9029-xDOI Listing
September 2008
10 Reads

Involvement of ERK/MAPK pathway in megakaryocytic differentiation of K562 cells induced by 3-hydrogenkwadaphnin.

Toxicol In Vitro 2008 Sep 27;22(6):1503-10. Epub 2008 May 27.

Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.

Since differentiation-induction therapy represents an attractive strategy for treatment of a wide range of malignancies, universal efforts have been devoted to find new and potent differentiation inducers devoid of general toxicities. In that respect, 3-hydrogenkwadaphnin (3-HK), a novel daphnane-type diterpene ester from Dendrostellera lessertii (Thymelaeaceae), was found to be an effective inducer of megakaryocytic differentiation in chronic myelogenous leukemia (CML) K562 cells without any adverse effects on normal cells [Moosavi, M.A. Read More

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http://dx.doi.org/10.1016/j.tiv.2008.05.005DOI Listing
September 2008
2 Reads

Kinetics of the interaction of desAABB-fibrin monomer with immobilized fibrinogen.

Biopolymers 2006 Sep;83(1):69-82

Living Matter Physics Laboratory, Institute of Physics of the Complex Matter, Swiss Federal Institute of Technology Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

The soluble and stable fibrin monomer-fibrinogen complex (SF) is well known to be present in the circulating blood of healthy individuals and of patients with thrombotic diseases. However, its physiological role is not yet fully understood. To deepen our knowledge about this complex, a method for the quantitative analysis of interaction between soluble fibrin monomers and surface-immobilized fibrinogen has been established by means of resonant mirror (IAsys) and surface plasmon resonance (BIAcore) biosensors. Read More

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http://dx.doi.org/10.1002/bip.20529DOI Listing
September 2006
2 Reads

Translational control: the cancer connection.

Int J Biochem Cell Biol 1999 Jan;31(1):1-23

Department of Biochemistry, St George's Hospital Medical School, London, UK.

There is now a growing body of evidence which suggests links between the regulation of protein synthesis and the disruption of cell behaviour that typifies cancer. This directed issue of the International Journal of Biochemistry and Cell Biology presents several review articles of relevance to this field. The topics covered include the significance of the regulation and overexpression of polypeptide chain initiation factors for cell transformation and malignancy, the role of mRNA structure in the control of synthesis of key growth regulatory proteins, the actions of the eIF2 alpha-specific protein kinase PKR in the control cell growth and apoptosis, and the involvement of the elongation factor eEF1 in oncogenesis. Read More

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January 1999
3 Reads

Transcription factors: an overview.

Authors:
D S Latchman

Int J Biochem Cell Biol 1997 Dec;29(12):1305-12

Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London Medical School, U.K.

This special issue of the International Journal of Biochemistry and Cell Biology contains a series of review articles and original papers dealing with the topic of transcription factors. The purpose of this introductory article is to provide an overview of these factors, their mechanism of action, their regulation and the manner in which alterations in them can result in disease. Read More

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December 1997
23 Reads

Mechanisms of tissue repair: from wound healing to fibrosis.

Int J Biochem Cell Biol 1997 Jan;29(1):5-17

Centre for Cardiopulmonary Biochemistry and Respiratory Medicine, University College London Medical School, Rayne Institute, U.K.

To set the scene for this Directed Issue on Mechanisms of Tissue Repair of The International Journal of Biochemistry and Cell Biology, this introductory overview briefly describes the process of wound healing and highlights some of the key recent advances in this field of research. It emphasizes the importance of cell-cell and cell-matrix interactions, particularly relating to the role of cell surface adhesion molecules, and describes developments that have led to a better understanding of the dynamic nature of matrix turnover with reference to negative and positive mediators that regulate procollagen gene expression and protein production. An important component of this Directed Issue is concerned with the development of tissue fibrosis, which accompanies a number of disease states and demonstrates remarkable parallels with the normal wound healing process; excessive amounts of matrix are laid down but the resolution of scarring, which would be anticipated in wound healing, is impaired. Read More

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January 1997
2 Reads

Biochemical characterization of hemorrhagic toxin from Crotalus viridis viridis (prairie rattlesnake) venom.

Int J Biochem 1994 Dec;26(12):1411-8

Department of Microbiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.

Hemorrhage, necrosis and edema are some of the effects often observed following snake bites. This paper reports studies on the isolation and biological properties of hemorrhagic toxin from Crotalus viridis viridis (Prairie rattlesnake) venom. A hemorrhagic toxin was isolated from C. Read More

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December 1994
3 Reads

The 5'-sequence of the murine Hox-b3 (Hox-2.7) gene and its intron contain multiple transcription-regulatory elements.

Int J Biochem 1994 Dec;26(12):1403-9

Skin Biology Research Center of Johnson & Johnson, R. W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey.

We sought to clone and characterize the murine Hox-b3 gene. In Xenopus embryos, the homologous gene has been shown to be responsive to retinoic acid, an agent which has profound effects on tissue growth and development. By plaque hybridization, using a partial, murine Hox-b3 cDNA as a probe, we screened a genomic library and isolated a series of overlapping clones. Read More

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December 1994
2 Reads

Characterization of human arylsulfatase A glycans.

Int J Biochem 1994 Dec;26(12):1395-401

Institute of Medical Biochemistry, Jagiellonian University, Krakow, Poland.

Despite numerous studies on arylsulfatase A, the structure of the glycans present in each of its two subunits has not been determined. This is important because the carbohydrate component of human arylsulfatase A synthesized in tumor tissues and transformed cells has been shown to undergo apparent changes. This study elucidates some of their major features. Read More

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December 1994
4 Reads

Two nuclear-coded subunits of mitochondrial complex I are similar to different domains of a bacterial formate hydrogenlyase subunit.

Int J Biochem 1994 Dec;26(12):1391-3

Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Portugal.

A computer comparison of protein sequences revealed similarity between the 30.4 kDa subunit of complex I from the fungus Neurospora crassa and the ORF5 subunit of formate hydrogenlyase from Escherichia coli. The ORF5 protein was previously known to be homologous to the 49 kDa component of the mitochondrial enzyme. Read More

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December 1994
1 Read

Calmodulin and cAMP dependent synaptic vesicle protein phosphorylation in rat cortex following lead exposure.

Authors:
R Sandhir K D Gill

Int J Biochem 1994 Dec;26(12):1383-9

Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

The effect of in vivo and in vitro lead exposure on calmodulin and cAMP dependent synaptic vesicle protein phosphorylation has been investigated. Lead could enhance calmodulin activity following in vitro and in vivo lead exposure. The calmodulin dependent synaptic vesicle protein phosphorylation was enhanced following in vivo and in vitro lead exposure resulting in the depletion of the neurotransmitters norepinephrine and acetylcholine. Read More

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December 1994
1 Read

Inhibition of porphobilinogenase by porphyrins in Saccharomyces cerevisiae.

Int J Biochem 1994 Dec;26(12):1377-81

Centro de Investigaciones sobre Porfirinas y Porfirias, CIPYP (CONICET-FCEN), UBA Ciudad Universitaria Pabellon II, Buenos Aires, Argentina.

The biosynthesis of uroporphyrinogen III, the precursor of hemes, chlorophylls, corrins and related structures, is catalyzed by the porphobilinogenase system (PBGase), a complex of two enzymes, PBG-Deaminase (PBG-D) and Isomerase. Although the separate enzymes have been studied in some detail less work has been performed on the properties of the complex. In this study the kinetic behaviour of the enzyme PBGase in a normal yeast strain, D273-10B, and its derivative B231 has been investigated. Read More

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December 1994
2 Reads

Partial purification and further characterization of the novel endoglucosaminidase from human serum that hydrolyses 4-methylumbelliferyl-N-acetyl-beta-D-chitotetraoside (MU-TACT hydrolase).

Int J Biochem 1994 Dec;26(12):1369-75

Department of Medical Chemistry, Vrije Universiteit, Amsterdam, The Netherlands.

A novel endoglucosaminidase, originally described by Den Tandt et al. [Int. J. Read More

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December 1994
2 Reads

Selective inactivation of muscarinic receptor subtypes.

Int J Biochem 1994 Dec;26(12):1357-68

Institute of Pharmacology, Syntex Discovery Research, Palo Alto, CA 94304.

Muscarinic receptors exist in multiple subtypes, denoted as M1, M2, M3 and M4, encoded by four distinct but related genes. A fifth gene product, m5, has also been predicted although this sequence awaits a pharmacological equivalent. Many tissues express more than one muscarinic receptor subtype, which may couple to different intracellular effectors and thus have different physiological roles. Read More

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December 1994
3 Reads

Mechanisms of initiating calcification. ATP-stimulated Ca- and Pi-depositing activity of isolated matrix vesicles.

Authors:
H H Hsu

Int J Biochem 1994 Dec;26(12):1351-6

Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City 66160-7410.

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December 1994
3 Reads

Interactions of adriamycin aglycones with mitochondria may mediate adriamycin cardiotoxicity.

Authors:
P M Sokolove

Int J Biochem 1994 Dec;26(12):1341-50

Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore 21201.

Adriamycin and related anthracyclines are potent oncolytic agents, the clinical utility of which is limited by severe cardiotoxicity. Aglycone metabolites of Adriamycin (5-20 microM) induce a Ca(2+)-dependent increase in the permeability of the inner mitochondrial membrane of both heart and liver mitochondria to small (< 1,500 Da) solutes; this phenomenon is accompanied by release of mitochondrial Ca2+, mitochondrial swelling, collapse of the membrane potential, oxidation of mitochondrial pyridine nucleotides [NAD(P)H], uncoupling, and a transition from the condensed to the orthodox conformation and is inhibited by ATP, dithiothreitol, the immunosuppressant cyclosporin A, and the ubiquitous polyamine spermine. Aglycones also modify mitochondrial sulfhydryl groups and induce a Ca2+ independent oxidation of mitochondrial NAD(P)H which appears to reflect electron transport from NADH to oxygen, mediated by the aglycones and resulting in the production of superoxide (O2-). Read More

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December 1994
1 Read

Induction of cytochrome P450 by toluene.

Authors:
T Nakajima R S Wang

Int J Biochem 1994 Dec;26(12):1333-40

Department of Hygiene, Shinshu University School of Medicine, Matsumoto, Japan.

At least six cytochrome P450 (P450) isoenzymes, including CYP1A1/2, CYP2A1, CYP2B1/2, CYP2C6, CYP2C11 and CYP2E1, are involved in the metabolism of toluene in rat liver. Toluene exposure induces CYP1A1/2, CYP2B1/2, CYP2E1 and CYP3A1, but decreases CYP2C11/6 and CYP2A1 in adult males. Both sex and age influence the induction of P450s by toluene: in general, the inductive effect is more prominent in younger than in older animals; in males than in females. Read More

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December 1994
1 Read

E1/E2 type cation transport ATPases: evidence for transient associations between protomers.

Int J Biochem 1994 Dec;26(12):1323-31

Biotechnological Center of M. V. Lomonosov Moscow State University, Russia.

E1/E2 type cation transport ATPases are known to exist in different conformeric states. Recent evidence characterizing these conformers in membrane is reviewed. A consensus view is proposed in which E2 conformers tend to form oligomeric complexes by lateral association between monomeric protomers and E1 conformers exhibit the opposite behaviour. Read More

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December 1994
2 Reads

Cytochrome P450 changes in rats with streptozocin-induced diabetes.

Authors:
N Shimojo

Int J Biochem 1994 Oct-Nov;26(10-11):1261-8

Department of Laboratory Medicine, Osaka City University Medical School, Japan.

It is known that the metabolism of some drugs is altered in diabetic patients and in rats with experimental diabetes induced by chemical agents, such as streptozocin. The induction and/or suppression of hepatic cytochrome P450 isozymes seen in diabetes seem to contribute to this alteration. Both metabolic and hormonal disturbances following insulin deficiency in diabetic rats are responsible for these changes. Read More

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March 1995
1 Read

Pancreatic islet hypertrophy in spontaneous maturity onset obese-diabetic CBA/Ca mice.

Int J Biochem 1994 Oct-Nov;26(10-11):1299-303

Department of Pharmacology, School of Medical Sciences, University of Bristol, U.K.

Mature male CBA/Ca mice develop a spontaneous mild diabetes-obesity syndrome which is characterized by hyperglycaemia, hyperinsulinaemia and insulin resistance, and resembles human Type II diabetes mellitus. Immunocytochemical staining of pancreas sections for insulin showed that the pancreas from mature obese mice possessed significantly enlarged islets compared to those from age-matched control (lean) mice. The pancreatic insulin content was significantly greater in 24-week-old obese mice (1. Read More

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March 1995
2 Reads

Alanine aminopeptidase of guinea-pig brain: a broad specificity cytoplasmic enzyme capable of hydrolysing short and intermediate length peptides.

Authors:
M Smyth G O'Cuinn

Int J Biochem 1994 Oct-Nov;26(10-11):1287-97

Department of Biochemistry, University College Galway, Ireland.

Alanine aminopeptidase is reported to be a broad specificity aminopeptidase acting on peptides of different lengths. In this study we wish to define the properties of the activity from guinea-pig brain and compare these properties with previous findings. Alanine amino-peptidase was purified from cytoplasm of guinea-pig brain by a four-step procedure involving chromatography on DE-52, hydroxylapatite, Sephacryl S-200 and DEAE-Sephacryl. Read More

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March 1995
1 Read

Purification of a cytosolic enzyme from human liver with phospholipid hydroperoxide glutathione peroxidase activity.

Int J Biochem 1994 Oct-Nov;26(10-11):1279-86

Food Molecular Biochemistry Department, Institute of Food Research, (Colney), Norwich, U.K.

Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is a selenoprotein which inhibits peroxidation of microsomes. The human enzyme, which may play an important role in protecting the cell from oxidative damage, has not been purified or characterized. PHGPx was isolated from human liver using ammonium sulphate fractionation, affinity chromatography on bromosulphophthalein-glutathione-agarose, gel filtration on Sephadex G-50, anion exchange chromatography on Mono Q resin and high resolution gel filtration on Superdex 75. Read More

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March 1995
1 Read

Cell surface glycoconjugates as modulators of embryo attachment to uterine epithelial cells.

Int J Biochem 1994 Oct-Nov;26(10-11):1269-77

Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, Houston, TX 77030.

Attachment of mammalian embryos to the uterine wall involves the coordinated development of both the embryo and the uterine epithelium to an attachment-competent state. This coordination is achieved directly or indirectly through the actions of ovarian steroids. Acquisition of attachment competence is proposed to reflect two processes. Read More

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March 1995
1 Read

Molecular mechanism of RNA phage morphogenesis.

Int J Biochem 1994 Oct-Nov;26(10-11):1249-60

Department of Genetics, University of Leeds, England.

Recent progress on the molecular mechanism of RNA phage morphogenesis is described. Functional studies, both in vivo and in vitro, are correlated with the latest structural studies on phages, their capsids and the assembly initiation RNA stem-loop. Read More

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March 1995
3 Reads

Biochemistry and molecular biology of drug-metabolizing sulfotransferase.

Authors:
M Matsui H Homma

Int J Biochem 1994 Oct-Nov;26(10-11):1237-47

Kyoritsu College of Pharmacy, Tokyo, Japan.

Sulfation is an important conjugation reaction in the metabolism of various xenobiotics and endogenous compounds and is catalyzed by sulfotransferase (ST) present in cytosols. The cloning studies on STs have provided the basis for the understanding of the ST multigene family. STs are classified into hydroxysteroid (or alcohol), aryl (or phenol), estrogen, flavonol and polysaccharide STs and recent developments in the molecular characterization of these isoforms are reviewed. Read More

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March 1995
2 Reads

Tyrosine protein kinase inhibition and cancer.

Authors:
J A Boutin

Int J Biochem 1994 Oct-Nov;26(10-11):1203-26

Institut de Recherches SERVIER, Département de Chimie des Peptides, Suresnes, France.

The various aspects of the research on tyrosine protein kinase inhibition and its connections with cancer are presented. The emphasis was made on the theoretical low toxic side effects of specific tyrosine protein kinase inhibitors. Particularly, the strategy of finding peptidic substrate-derived inhibitors or modulators is discussed, with an almost complete compendium of the tyrosine protein kinase peptidic substrates published so far. Read More

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March 1995
1 Read

A compendium of reviews in biochemistry and molecular biology published in the second half of 1993.

Authors:
I G Giles

Int J Biochem 1994 Oct-Nov;26(10-11):1163-201

Department of Biochemistry, University of Southampton, UK.

1. A compendium of reviews and mini-reviews in Biochemistry and Molecular Biology published in the second half of 1993 is presented. In all 1063 titles are listed from 127 different publications. Read More

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March 1995
1 Read

Modulation of nerve and glial function by adenosine--role in the development of ischemic damage.

Int J Biochem 1994 Oct-Nov;26(10-11):1227-36

Max Planck Institute for Psychiatry, Department of Neuromorphology, Martinsried, Germany.

Adenosine is released during brain ischemia and provides neuroprotection by actions on nerve and glial cells. Activation of the adenosine A1 receptor enhances the K+ and Cl- conductance in neurons, leading to membrane hyperpolarization and postsynaptic reduction of neuronal Ca2+ influx through voltage- and NMDA receptor-dependent channels. In addition adenosine A1 receptor activation decreases excitatory amino acid release, possibly via inhibition of N- and P-type Ca2+ channels. Read More

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March 1995
36 Reads

Platelet-activating factor acetylhydrolase (PAF-AH) in human kidney.

Int J Biochem 1994 Sep;26(9):1157-62

University of Athens, Department of Chemistry, Greece.

1. PAF-AH activity in human kidney (cortex and medulla) has been demonstrated and shares the following properties. 2. Read More

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September 1994
1 Read

DNase-I-like enzyme from the carp liver--inhibition by muscle and endogenous actin.

Int J Biochem 1994 Sep;26(9):1147-55

Institute of Biochemistry, University of Wroclaw, Poland.

1. DNase-I-like activity occurs in the carp (Cyprinus carpio) liver cytosol (supernatant 105,000 g). 2. Read More

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September 1994
2 Reads

Tissue lipoperoxidation and glutathione peroxidase activity in puromycin aminonucleoside injected rats.

Int J Biochem 1994 Sep;26(9):1139-45

Department of Nephrology and Mineral Metabolism, Instituto Nacional de la Nutrición Salvador Zubirán, México D.F., Mexico.

1. Lipoperoxidation (LPx) and glutathione peroxidase (GPx) activity were measured in kidney, liver, heart, lung, brain and testis from control and puromycin aminonucleoside (PAN) injected rats on days 1-6, 8, 10, 16 and 22 after vehicle or PAN injection. 2. Read More

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September 1994
4 Reads

Solubilization, partial purification and functional reconstitution of a sheep brain endoplasmic reticulum anion channel.

Int J Biochem 1994 Sep;26(9):1129-38

Department of Biochemistry, University of Edinburgh, U.K.

1. An intracellular anion channel, known to be co-localized in brain endoplasmic reticulum membranes with ryanodine-sensitive calcium-release channels, was incorporated into voltage-clamped planar lipid bilayers from sheep brain microsomal membrane vesicles. 2. Read More

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September 1994
1 Read

Effect of methyl methacrylate on mitochondrial function and structure.

Authors:
Z Bereznowski

Int J Biochem 1994 Sep;26(9):1119-27

Department of Prosthetic Dentistry, Academic Medical School in Gdański, Poland.

1. Treatment of isolated rat liver mitochondria with methyl methacrylate (MM) produced membrane disruption as evidenced by the release of citrate synthase, and changes in the ultrastructure of mitochondria. 2. Read More

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September 1994
2 Reads

Spectral analysis of Fe(III)-complex reduction by hemoglobin: possible mechanisms of interaction.

Int J Biochem 1994 Sep;26(9):1111-7

Department of Chemistry, University of South Alabama, Mobile 36688.

1. Hemoglobin is capable of electron transfer to Fe(III)-complexes of ATP, EDTA, NTA, and citrate leading to formation of reduced Fe(II) and its concurrent release from these chelating compounds as evident in the formation of a Fe(II)-Tris 2,2' bipyridine complex. 2. Read More

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September 1994
1 Read

Activation of 3-methyl-branched fatty acids in rat liver.

Int J Biochem 1994 Sep;26(9):1095-101

Katolieke Universiteit Leuven, Belgium.

1. Subcellular fractionation of rat liver revealed that 3-methylmargaric acid, a monobranched phytanic acid analogue, can be activated by mitochondria, endoplasmic reticulum and peroxisomes. 2. Read More

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September 1994
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Different oxidative pathways of isonicotinic acid hydrazide and its meta-isomer, nicotinic acid hydrazide.

Int J Biochem 1994 Sep;26(9):1081-93

Department of Pharmacology, Medical School, University of Stellenbosch, Tygerberg, South Africa.

1. Superoxide was generated during the auto-oxidation of the antituberculous drug, isonicotinic acid hydrazide (INH), but not with its meta-isomer, nicotinic acid hydrazide (NH). During Fe(3+)-stimulated oxidation of INH and NH, aromatic hydroxylation occurred which was inhibited by the chelating agent, phytic acid. Read More

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September 1994
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Net glucose production from acetone in isolated murine hepatocytes. The effect of different pretreatments of mice.

Int J Biochem 1994 Sep;26(9):1069-79

Semmelweis University Medical School, First Institute of Biochemistry, Budapest, Hungary.

1. To evaluate the condition under which net glucose production from acetone, added as sole substrate, occurs different pretreatments of mice, in combination with starvation, were used; (i) acetone pretreatment (acetone is a known inducer of cytochrome P-450 isozymes involved in this pathway), (ii) fructose pretreatment (to induce NADPH+H+ generating enzymes) or (iii) their combination. 2. Read More

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September 1994
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Transcriptional regulation of environmentally inducible genes in plants by an evolutionary conserved family of G-box binding factors.

Int J Biochem 1994 Sep;26(9):1055-68

Department of Horticultural Sciences, Program in Plant Molecular and Cellular Biology, Gainesville, FL 32611.

1. In reviewing a number of the most intensely studied environmentally inducible promoters it becomes clear that the presence of two cis-acting elements are critical for promoter activity, one of which is the G-box (CCACGTGG). A mutation in one of the two elements abolishes or severely reduces the ability of the promoter to respond to environmental changes. Read More

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September 1994
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