4,499 results match your criteria International Journal of Artificial Organs[Journal]


Expansion of mouse hematopoietic stem/progenitor cells in three-dimensional cocultures on growth-suppressed stromal cell layer.

Int J Artif Organs 2019 Feb 12:391398819827596. Epub 2019 Feb 12.

Department of Biomedical Engineering, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

With the aim of establishing an effective method to expand hematopoietic stem/progenitor cells for application in hematopoietic stem cell transplantation, we performed ex vivo expansion of hematopoietic stem/progenitor cells derived from mouse fetal liver cells in three-dimensional cocultures with stromal cells. In these cocultures, stromal cells were first cultured within three-dimensional scaffolds to form stromal layers and then fetal liver cells containing hematopoietic cells were seeded on these scaffolds to expand the hematopoietic cells over the 2 weeks of coculture in a serum-containing medium without the addition of cytokines. Prior to coculture, stromal cell growth was suppressed by treatment with the DNA synthesis inhibitor mitomycin C, and its effect on hematopoietic stem/progenitor cell expansion was compared with that in control cocultures in which fetal liver cells were cocultured with three-dimensional freeze-thawed stromal cells. Read More

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http://dx.doi.org/10.1177/0391398819827596DOI Listing
February 2019

The positive influence of psychological intervention on the level of anxiety and depression in dialysis patients: A pilot study.

Int J Artif Organs 2019 Jan 25:391398818823765. Epub 2019 Jan 25.

University of Warsaw, Warsaw, Poland.

Medical progress in dialysis therapy made it possible to treat patients with the end-stage renal disease for many years. But at the other side it may lead to profound changes in everyday life and may induce depression and anxiety. The research presented in this article explores the influence of psychological interventions on anxiety and depression levels in patients undergoing dialysis therapy. Read More

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http://dx.doi.org/10.1177/0391398818823765DOI Listing
January 2019

Risk factors for adverse outcomes after left ventricular assist device implantation and extracorporeal cardiopulmonary resuscitation.

Int J Artif Organs 2019 Jan 17:391398818817327. Epub 2019 Jan 17.

1 Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany.

Left ventricular assist device implantation following extracorporeal cardiopulmonary resuscitation has been associated with ambivalent results. In a series of patients who underwent left ventricular assist device implantation after extracorporeal cardiopulmonary resuscitation, we investigated whether the outcome can be predicted by preoperative risk factors or established risk scores. Primary endpoint was a composite of mortality and severe neurological disabling over 1 year of follow-up. Read More

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http://dx.doi.org/10.1177/0391398818817327DOI Listing
January 2019

A pilot study investigating the effect of pedalling exercise during dialysis on 6-min walking test and hand grip and pinch strength.

Int J Artif Organs 2019 Jan 14:391398818823761. Epub 2019 Jan 14.

UCL Department of Nephrology, Royal Free Hospital, UCL Medical School, University College London, London, UK.

Introduction:: Haemodialysis patients are at an increased risk of sarcopenia. Physical inactivity is now recognised as a major cause of muscle wasting in haemodialysis patients. It is unclear as to what and how much exercise is required to show benefit. Read More

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http://dx.doi.org/10.1177/0391398818823761DOI Listing
January 2019

Antibody-mediated rejection after cardiac transplant: Treatment with immunoadsorption, intravenous immunoglobulin, and anti-thymocyte globulin.

Int J Artif Organs 2019 Jan 14:391398818823763. Epub 2019 Jan 14.

1 Department of Cardiovascular Surgery, Heinrich-Heine University Hospital, Düsseldorf, Germany.

Antibody-mediated rejection of allograft is a poorly understood problem after cardiac transplantation that complicates the postoperative course and impairs the graft function and overall survival. Although plasmapheresis and intravenous immunoglobulins have been used as standard therapies for years, there is no consensus about antibody-mediated rejection therapy and most transplantation centers have their own protocols. We describe herein a successful treatment for an acute antibody-mediated rejection of cardiac allograft combining immunoadsorption, intravenous immunoglobulins, and anti-thymocyte globulin, which manifested with polymorphic ventricular tachycardia and right ventricular dysfunction. Read More

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http://dx.doi.org/10.1177/0391398818823763DOI Listing
January 2019
1 Read

A new hydrophilic polysulfone hemodialysis membrane can prevent platelet-neutrophil interactions and successive neutrophil activation.

Int J Artif Organs 2019 Jan 14:391398818823767. Epub 2019 Jan 14.

1 Pharmaceutical Research Laboratories, Toray Industries, Inc., Kamakura, Japan.

Purpose:: Microaggregates have often been observed during hemodialysis and are clearly associated with complications of hemodialysis therapy. In this study, we aimed to clarify the effects of two polysulfone membranes, with different abilities to activate blood cells, on the formation of these microaggregates; we also investigated their molecular mechanisms.

Methods:: Human whole blood was circulated through a mini-module dialyzer using the membranes in vitro; platelet-neutrophil complexes in blood were determined by flow cytometry. Read More

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http://dx.doi.org/10.1177/0391398818823767DOI Listing
January 2019
1 Read

Clinical effects of hemoadsorption with CytoSorb in patients with severe acute pancreatitis: A case series.

Int J Artif Organs 2019 Jan 14:391398818823762. Epub 2019 Jan 14.

3 "Dan Setlacec" Center of Gastrointestinal Disease and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania.

Hemoadsorption using CytoSorb has recently gained attention as a new therapy aimed at modulating the inflammatory response syndrome in critically ill patients. The aim of our study was to assess the clinical effects of CytoSorb in patients with severe acute pancreatitis. We prospectively included 12 patients admitted to the intensive care unit for severe acute pancreatitis. Read More

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http://journals.sagepub.com/doi/10.1177/0391398818823762
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http://dx.doi.org/10.1177/0391398818823762DOI Listing
January 2019
2 Reads

Ventricular assist device in a patient with congenitally corrected transposition of the great arteries and situs inversus totalis.

Int J Artif Organs 2019 Jan 10:391398818823768. Epub 2019 Jan 10.

1 Clinic of Cardiovascular Surgery, Heinrich Heine University Dusseldorf, Dusseldorf, Germany.

Congenitally corrected transposition of the great arteries and situs inversus totalis are rare congenital anomalies. While congenital heart diseases affect about 0.75%-0. Read More

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http://dx.doi.org/10.1177/0391398818823768DOI Listing
January 2019
1 Read

Numerical investigation of the influence of a bearing/shaft structure in an axial blood pump on the potential for device thrombosis.

Int J Artif Organs 2019 Jan 10:391398818823769. Epub 2019 Jan 10.

1 School of Energy and Power Engineering, Beihang University, Beijing, China.

Adverse events caused by flow-induced thrombus formation around the bearing/shaft of an axial blood pump remain a serious problem for axial blood pumps. Moreover, excessive anticoagulation with thrombosis around the bearing potentially increases the risk of postoperative gastrointestinal bleeding. The purpose of this study is to analyze the influence of the bearing structure on the thrombosis potential of an axial blood pump. Read More

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http://dx.doi.org/10.1177/0391398818823769DOI Listing
January 2019
1 Read

Mechanical circulatory support: 60 years of evolving knowledge.

Authors:
Amedeo Terzi

Int J Artif Organs 2019 Jan 8:391398818822267. Epub 2019 Jan 8.

UOS Chirurgia dei Trapianti, ASST Papa Giovanni XXIII, Bergamo, Italy.

Since the 1950s when the first devices for mechanical circulatory support were developed, there has been an impressive evolution of their technology. The first pioneering pumps were used to rescue acute complications after cardiac surgery. Advances in technology, increased knowledge of flow dynamics, and a more appropriate selection of the patients who actually need this support have contributed to significantly improve the benefits of this therapy. Read More

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http://journals.sagepub.com/doi/10.1177/0391398818822267
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http://dx.doi.org/10.1177/0391398818822267DOI Listing
January 2019
4 Reads

First successful hemoadsorption using CytoSorb® in a septic pediatric patient in Kazakhstan: A case report.

Int J Artif Organs 2019 Jan 7:391398818819953. Epub 2019 Jan 7.

1 National Research Center for Maternal and Child Health, Astana, Kazakhstan.

Purpose:: For the first time in Kazakhstan, we have used a combined extracorporeal support, by including the CytoSorb system in a continuous veno-venous hemofiltration system in an 8-month-old patient with a body weight of 5600 g.

Results:: The CytoSorb therapy session resulted in a reduction of inflammation markers IL-6, S100, procalcitonin, and C-reactive protein. Simultaneously, the level of transaminases, creatine kinase, and troponin were normalized, by the end of the session patient hemodynamics were stable and there was no need for vasopressors, acid-base balance was maintained, and the patient was weaned from mechanical ventilation to spontaneous breathing. Read More

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http://dx.doi.org/10.1177/0391398818819953DOI Listing
January 2019
5 Reads

Amnion-derived mesenchymal stem cells improve viability of endothelial cells exposed to shear stress in ePTFE grafts.

Int J Artif Organs 2018 Dec 26:391398818815470. Epub 2018 Dec 26.

1 Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.

Purpose:: Blood vessel reconstruction is an increasing need of patients suffering from cardiovascular diseases. For the development of microvascular prostheses, efficient endothelialization is mandatory to prevent graft occlusion. Here, we assessed the impact of amnion-derived mesenchymal stem/stromal cells (hAMSC), known for their important angiogenic potential, on the integrity and stability of endothelial cells exposed to shear stress in vascular grafts. Read More

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http://dx.doi.org/10.1177/0391398818815470DOI Listing
December 2018

Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use.

Int J Artif Organs 2018 Dec 26:391398818817326. Epub 2018 Dec 26.

1 Swansea University Medical School, Swansea, UK.

Heart failure remains a disease of ever increasing prevalence in the modern world. Patients with end-stage heart failure are being referred increasingly for mechanical circulatory support. Mechanical circulatory support can assist patients who are ineligible for transplant and stabilise eligible patients prior to transplantation. Read More

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http://dx.doi.org/10.1177/0391398818817326DOI Listing
December 2018
10 Reads

It keeps on turning: Effects of prolonged long-term left ventricular assist device support as a bridge to heart transplantation.

Int J Artif Organs 2018 Dec 24:391398818815471. Epub 2018 Dec 24.

1 Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, Middlesex, UK.

Objectives:: Increasing incidence of end-stage heart failure has moved the therapy with left ventricular assist devices to the forefront of surgical treatment. Moreover, continuous sophistication in this technology has resulted in increasing proportion of patients on prolonged support. Early and late complications after left ventricular assist device as a bridge to transplantation and present factors associated with long-term support and long-term outcomes of patients supported for at least 1 year were compared. Read More

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http://dx.doi.org/10.1177/0391398818815471DOI Listing
December 2018
1 Read

Transient power elevation during iron dextran infusion in a patient with a continuous-flow left ventricular assist device.

Int J Artif Organs 2018 Dec 16:391398818818565. Epub 2018 Dec 16.

6 Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH, USA.

Anemia is common in patients with mechanical circulatory support and is associated with increased morbidity. Repletion using parenteral iron infusions has been proven to be beneficial in patients with heart failure. In this report, we describe a case of increased power and flows of continuous-flow left ventricular assist device (LVAD) during an iron dextran infusion. Read More

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http://dx.doi.org/10.1177/0391398818818565DOI Listing
December 2018

In vitro removal of anti-infective agents by a novel cytokine adsorbent system.

Int J Artif Organs 2018 Dec 13:391398818812601. Epub 2018 Dec 13.

1 Department of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Objectives:: The aim of this study is to describe the in vitro adsorption of anti-infective drugs onto an extracorporeal cytokine adsorber.

Methods:: Various anti-infective drugs (β-lactams, quinolones, aminoglycosides, glycopeptides, azole antimycotics) were prepared in normal saline 0.9% and human albumin 5%, and pumped through a cytokine cartridge (CytoSorb; CytoSorbents Corporation, Monmouth Junction, NJ, USA) at a flow rate of 1. Read More

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http://journals.sagepub.com/doi/10.1177/0391398818812601
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http://dx.doi.org/10.1177/0391398818812601DOI Listing
December 2018
2 Reads

Bloodstream infections during post-cardiotomy extracorporeal membrane oxygenation: Incidence, risk factors, and outcomes.

Int J Artif Organs 2018 Dec 11:391398818817325. Epub 2018 Dec 11.

2 ECMO Team, IRCCS Policlinico San Donato, Milan, Italy.

Introduction:: Veno-arterial extracorporeal membrane oxygenation after heart surgery is a relatively common procedure. It is easily applicable but associated with a number of complications, including bloodstream infections. The aim of this study is to determine the current rate and the risk factors related to bloodstream infections acquired during post-cardiotomy veno-arterial extracorporeal membrane oxygenation. Read More

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http://dx.doi.org/10.1177/0391398818817325DOI Listing
December 2018
1 Read

Patient-specific design process and evaluation of a hip prosthesis femoral stem.

Int J Artif Organs 2018 Dec 11:391398818815479. Epub 2018 Dec 11.

5 Department of Mechanical and Control Engineering, Tokyo Institute of Technology, Tokyo, Japan.

Introduction:: There are several commercially available hip implant systems. However, for some cases, custom implant designed based on patient-specific anatomy can offer the patient the best available implant solution. Currently, there is a growing trend toward personalization of medical implants involving additive manufacturing into orthopedic medical implants' manufacturing. Read More

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http://journals.sagepub.com/doi/10.1177/0391398818815479
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http://dx.doi.org/10.1177/0391398818815479DOI Listing
December 2018
11 Reads

Development of exercise-related values in heart failure patients supported with a left ventricular assist device.

Int J Artif Organs 2018 Dec 6:391398818815492. Epub 2018 Dec 6.

1 Schüchtermann-Klinik Bad Rothenfelde, Bad Rothenfelde, Germany.

Following implantation of a left ventricular assist device, the build-up and long-term maintenance of adequate exercise capacity and functional performance become crucial. The aim of this study was to observe the development of exercise-related values at different times, as well as to detect possible influencing factors. We performed a prospective single-centre study: 10 patients (63 years, 100% male, body mass index = 27. Read More

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http://dx.doi.org/10.1177/0391398818815492DOI Listing
December 2018
5 Reads

Antithrombotic properties of hemofilter coated with polymer having a hydrophilic blood-contacting layer.

Int J Artif Organs 2018 Nov 29:391398818815480. Epub 2018 Nov 29.

1 Department of Medical Engineering, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan.

Objective:: Extracorporeal circulation devices are coated with a biocompatible polymer coating agent (BPCA) that has a hydrophilic blood-contacting layer, but hemofilters are not. We aimed to investigate the antithrombotic properties of a BPCA-coated hemofilter.

Methods:: Four experiments using BPCA-coated circuits and non-coated hemofilters and four experiments using BPCA-coated circuits and BPCA-coated hemofilters were performed with whole human blood and compared by measuring the circuit pressure every 5 min, antithrombin activity every 40 min, and thrombin-antithrombin complex every 40 min, for a total of 240 min of recirculation. Read More

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http://dx.doi.org/10.1177/0391398818815480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343425PMC
November 2018
8 Reads

Development of a simvastatin loaded injectable porous scaffold in situ formed by phase inversion method for bone tissue regeneration.

Int J Artif Organs 2019 Feb 28;42(2):72-79. Epub 2018 Nov 28.

4 Department of Animal and Marine Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.

Introduction:: The use of injectable scaffolds as a minimally invasive method is a good choice in tissue engineering applications. A critical parameter for the tissue engineering scaffolds is a suitable morphology with interconnected pores. We present the development of a simvastatin loaded scaffold that forms in situ and provides the porous structure with interconnected pores. Read More

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http://dx.doi.org/10.1177/0391398818806161DOI Listing
February 2019

Successful decellularization of thick-walled tissue: Highlighting pitfalls and the need for a multifactorial approach.

Int J Artif Organs 2019 Jan 16;42(1):17-24. Epub 2018 Nov 16.

Department of Cardiac Surgery, Laboratory for Tissue Engineering, Grosshadern Medical Centre, Ludwig-Maximilians-University, Munich, Germany.

Introduction:: Decellularization of thick tissue is challenging and varying. Therefore, we tried to establish a multifactorial approach for reliable aortic wall decellularization.

Methods:: Porcine aortic walls were decellularized according to different procedures. Read More

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http://dx.doi.org/10.1177/0391398818805624DOI Listing
January 2019
7 Reads

A new dynamic model for in vitro evaluation of intravascular devices.

Int J Artif Organs 2018 Nov 4:391398818806158. Epub 2018 Nov 4.

2 Department of Cardiac Surgery, Ghent University Hospital (UZ Gent), Gent, Belgium.

Introduction:: A dynamic model to evaluate thrombus formation on intravascular catheters in vitro is presented. The model enables fluid infusion, variation in the catheter orientation, and variable flow conditions. It was applied on a catheter used to shunt cerebrospinal fluid to a vein, a dural venous sinus, for the treatment of hydrocephalus. Read More

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http://dx.doi.org/10.1177/0391398818806158DOI Listing
November 2018
6 Reads

Impact of setup orientation on blend electrospinning of poly-ε-caprolactone-gelatin scaffolds for vascular tissue engineering.

Int J Artif Organs 2018 Nov;41(11):801-810

Institute for Multiphase Processes, Leibniz University Hannover, Hannover, Germany.

Introduction:: This article explores the effect of horizontal and vertical setups on blend electrospinning with two polymers having vastly different properties - poly-ε-caprolactone and gelatin, and subsequent effect of the resulting microstructure on viability of seeded cells.

Methods:: Poly-ε-caprolactone and gelatin of varying blend concentrations were electrospun in horizontal and vertical setup orientations. NIH 3T3 fibroblasts were seeded on these scaffolds to assess cell viability changes in accordance with change in microstructure. Read More

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http://dx.doi.org/10.1177/0391398818803478DOI Listing
November 2018
6 Reads

Chondrocytes cultured in silk-based biomaterials maintain function and cell morphology.

Int J Artif Organs 2018 Oct 30:391398818806156. Epub 2018 Oct 30.

5 NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China.

Objective:: To characterize the morphology of chondrocytes and the expression and secretion of active collagen II by these cells cultured within a regenerated silk fibroin film. Silk fibroin film cytocompatibility and the effect of silk fibroin on chondrocytes in vitro were also evaluated.

Methods:: Chondrocytes were transfected with a lentivirus containing a green fluorescent protein marker and cultured within a regenerated silk fibroin film. Read More

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http://dx.doi.org/10.1177/0391398818806156DOI Listing
October 2018
2 Reads

Blood damage in Left Ventricular Assist Devices: Pump thrombosis or system thrombosis?

Int J Artif Organs 2018 Oct 24:391398818806162. Epub 2018 Oct 24.

1 Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.

Introduction:: Despite significant technical advancements in the design and manufacture of Left Ventricular Assist Devices, post-implant thrombotic and thromboembolic complications continue to affect long-term outcomes. Previous efforts, aimed at optimizing pump design as a means of reducing supraphysiologic shear stresses generated within the pump and associated prothrombotic shear-mediated platelet injury, have only partially altered the device hemocompatibility.

Methods:: We examined hemodynamic mechanisms that synergize with hypershear within the pump to contribute to the thrombogenic potential of the overall Left Ventricular Assist Device system. Read More

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http://journals.sagepub.com/doi/10.1177/0391398818806162
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http://dx.doi.org/10.1177/0391398818806162DOI Listing
October 2018
11 Reads
1.450 Impact Factor

Couette shearing device for the investigation of shear-induced damage of the primary hemostasis by left ventricular assist devices.

Int J Artif Organs 2018 Oct 22:391398818802950. Epub 2018 Oct 22.

Biofluid Mechanics Laboratory, Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Introduction:: Continuous-flow left ventricular assist devices have evolved from short-time therapy into permanent or so-called destination therapy. One complication in long-term usage is bleeding, which is presumably attributed to shear-induced interference of left ventricular assist devices with the coagulation system.

Methods:: The influence of dynamic shear stresses on primary hemostasis by single or multiple passes through left ventricular assist devices was investigated. Read More

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http://dx.doi.org/10.1177/0391398818802950DOI Listing
October 2018
8 Reads

Characterization and biological properties of a novel synthesized silicon-substituted hydroxyapatite derived from eggshell.

Int J Artif Organs 2018 Oct 22:391398818806159. Epub 2018 Oct 22.

1 Faculty of New Science and Technology, Semnan University, Semnan, Iran.

In the present study, the effect of adding different concentrations of silicon on physical, mechanical and biological properties of a synthesized aqueous precipitated eggshell-derived hydroxyapatite (e-HA) was evaluated. No secondary phases were detected by X-ray diffraction for the specimens e-HA and e-HA containing silicon (Si-e-HAs) before and after heating at 1200°C. A reduction in the crystallite size and a-axis as well as an increase in c-axis was occurred when silicon replacement was happened in the structure of e-HA. Read More

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http://dx.doi.org/10.1177/0391398818806159DOI Listing
October 2018
15 Reads

Does the plasma refilling coefficient change during hemodialysis sessions?

Int J Artif Organs 2018 Nov 2;41(11):706-713. Epub 2018 Oct 2.

1 Department of Modeling and Supporting of Internal Organs Functions, Nalecz Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences, Warsaw, Poland.

The filtration coefficient in the Starling equation is an important determinant of plasma refilling during hemodialysis. A method for calculating from clinical data an estimate of the filtration coefficient, called the refilling coefficient, was proposed in the past. The assumption behind this method was that the only drive for refilling is the increase in plasma oncotic pressure, and the remaining Starling forces have negligible effect. Read More

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http://dx.doi.org/10.1177/0391398818803439DOI Listing
November 2018
12 Reads

Evaluation of pre- and post-dilution continuous veno-venous hemofiltration on leukocyte and platelet function in patients with sepsis.

Int J Artif Organs 2018 Oct 2:391398818801292. Epub 2018 Oct 2.

3 Department of Anesthesiology, School of Medicine, Sapporo Medical University, Sapporo, Japan.

Objective: We investigated the differences in biocompatibility pre- and post-dilution during continuous veno-venous hemofiltration in patients with sepsis, focusing on leukocyte and platelet function.

Patients And Methods: Subjects were 12 patients with septic shock who underwent veno-venous hemofiltration for acute kidney injury between March 2016 and September 2017. The first six patients received pre-dilution veno-venous hemofiltration, and the next six patients received post-dilution veno-venous hemofiltration. Read More

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http://dx.doi.org/10.1177/0391398818801292DOI Listing
October 2018
8 Reads

Young ESAO challenges in artificial organs.

Int J Artif Organs 2018 11 2;41(11):687-689. Epub 2018 Oct 2.

2 Institute for Multiphase Processes, Leibniz University Hannover, Hannover, Germany.

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http://dx.doi.org/10.1177/0391398818804133DOI Listing
November 2018
1 Read

Optimal drainage cannula position in dual cannulation for veno-venous extracorporeal membrane oxygenation.

Int J Artif Organs 2018 Dec 17;41(12):867-871. Epub 2018 Sep 17.

2 Department of Artificial Organs, National Cerebral and Cardiovascular Center, Osaka, Japan.

Introduction:: Recently, the use of veno-venous extracorporeal membrane oxygenation for adult patients with severe acute respiratory failure has increased. We previously investigated the optimal return cannula position; however, the optimal drainage cannula position has not yet been fully clarified. The aim of this study was to investigate the optimal drainage cannula position. Read More

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http://dx.doi.org/10.1177/0391398818795357DOI Listing
December 2018
2 Reads

Salvage extracorporeal membrane oxygenation in induction-associated acute respiratory distress syndrome in acute leukemia patients: A case series.

Int J Artif Organs 2018 Sep 17:391398818799160. Epub 2018 Sep 17.

3 Trauma/Critical Care Surgery Service, San Antonio Military Medical Center, JBSA Fort Sam Houston, TX, USA.

Background: The prognosis of hematologic malignancies has improved over the past three decades. However, the prognosis in hematologic malignancies with severe acute respiratory distress syndrome has remained poor. Initial reports regarding the utility of extracorporeal membrane oxygenation in hematologic malignancies have been controversial, with limited evaluations of acute leukemia patients supported by extracorporeal membrane oxygenation. Read More

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http://dx.doi.org/10.1177/0391398818799160DOI Listing
September 2018
20 Reads

Sex-age-specific handgrip strength and mortality in an incident hemodialysis cohort: The risk explained by nutrition and comorbidities.

Int J Artif Organs 2018 Dec 11;41(12):825-832. Epub 2018 Sep 11.

3 Unit of Clinical Epidemiology and Evidence Based Medicine, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Brazil.

Objective:: To investigate associations of sex-age-specific handgrip strength by a dynamometer with all-cause mortality and the percent excess risk explained (%ERE) by comorbidities and nutritional indicators in incident maintenance hemodialysis patients.

Methods:: Prospective cohort of 413 adult patients (165 women, 248 men, 299 <60 years and 114 ⩾60 years) with <6 months (82% <3 months) on dialysis enrolled in PROHEMO in Salvador, Brazil. Low and high handgrip strength groups were based on sex-age-specific cutoffs (17. Read More

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http://dx.doi.org/10.1177/0391398818793088DOI Listing
December 2018
6 Reads

Tubular vesicopyelostomy for the management of types 2 and 3 (long-segment) ureteric stenosis after kidney transplantation.

Int J Artif Organs 2018 Sep 5:391398818796346. Epub 2018 Sep 5.

2 Department of Internal Nephrology, University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.

Late ureteral stenosis following kidney transplantation needs immediate correction in order to protect allograft function and requires a complicated surgical procedure. In this study, we present the long-term results of tubular bladder reconfiguration and cystopyelostomy (tubular vesicopyelostomy), an innovative and practical procedure for the management of long-segment ureteric stenosis (types 2 and 3) after transplantation. Between 2002 and 2017, 722 kidney transplant patients were monitored at the University of Medical Sciences, Bozyaka Organ Transplantation and Research Center. Read More

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http://dx.doi.org/10.1177/0391398818796346DOI Listing
September 2018
5 Reads

Surface modification of metallic materials designed for a new generation of artificial heart valves.

Int J Artif Organs 2018 Dec 24;41(12):854-866. Epub 2018 Aug 24.

5 Joanneum Research Forschungsges mbH, Institute of Surface Technologies and Photonics, Functional Surfaces, Niklasdorf, Austria.

Purpose:: The main goal of this work was to develop haemocompatibile thin film materials dedicated to novel flexible mechanical heart valves intended for pulsatile ventricle assist devices.

Methods:: The studies performed have led to the selection of a material for the surface modification of the metallic scaffold. Haemocompatible, biofunctional, ultra-elastic, thin carbon-based coatings were proposed. Read More

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http://dx.doi.org/10.1177/0391398818794064DOI Listing
December 2018
4 Reads

The use of a virtual patient to follow changes in arterial blood gases associated with therapeutic thoracentesis.

Int J Artif Organs 2018 Nov 24;41(11):690-697. Epub 2018 Aug 24.

2 Department of Internal Medicine, Pulmonary Diseases & Allergy, Medical University of Warsaw, Warsaw, Poland.

Purposes:: Some controversies exist on the effect of therapeutic thoracentesis (TT) on arterial blood oxygen tension. The aim of this study was to evaluate this issue using a previously developed virtual patient.

Methods:: The analysis was based and supported by clinical data collected during 36 TT. Read More

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http://dx.doi.org/10.1177/0391398818793354DOI Listing
November 2018
6 Reads

Normal fluid stresses are prevalent in rotary ventricular assist devices: A computational fluid dynamics analysis.

Int J Artif Organs 2018 Nov 24;41(11):738-751. Epub 2018 Aug 24.

Department of Mechanical Engineering, University of Bath, Bath, UK.

Despite the evolution of ventricular assist devices, ventricular assist device patients still suffer from complications due to the damage to blood by fluid dynamic stress. Since rotary ventricular assist devices are assumed to exert mainly shear stress, studies of blood damage are based on shear flow experiments. However, measurements and simulations of cell and protein deformation show normal and shear stresses deform, and potentially damage, cells and proteins differently. Read More

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http://dx.doi.org/10.1177/0391398818792757DOI Listing
November 2018
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Visualization of erythrocyte deformation induced by supraphysiological shear stress.

Int J Artif Organs 2018 Dec 21;41(12):838-844. Epub 2018 Aug 21.

1 Graduate School of Engineering and Science, Shibaura Institute of Technology, Saitama City, Japan.

To elucidate development of shear-induced damage in erythrocytes, it is necessary to visualize erythrocytes under high-shear flow. Therefore, we prototyped a special shear flow chamber with a counter-rotating mechanism consisting of a transparent acrylic cone and a glass plate. The flow chamber was mounted on an inverted microscope and illuminated by a 350-W metal halide lamp. Read More

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http://dx.doi.org/10.1177/0391398818793387DOI Listing
December 2018
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Extracorporeal membrane oxygenation in trauma: A single institution experience and review of the literature.

Int J Artif Organs 2018 Dec 17;41(12):845-853. Epub 2018 Aug 17.

1 Division of Trauma and Acute Care Surgery, Los Angeles County + USC Medical Center, Los Angeles, CA, USA.

Introduction:: Limited options exist for cardiovascular support of the trauma patient in extremis. This patient population offers challenges that are often considered insurmountable. This article identifies a heterogeneous group of trauma patients in extremis who may benefit from extracorporeal membrane oxygenation. Read More

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http://dx.doi.org/10.1177/0391398818794111DOI Listing
December 2018
11 Reads

Abstracts from the 45th ESAO Congress, 12-15 September 2018, Madrid, Spain.

Authors:

Int J Artif Organs 2018 09;41(9):486-631

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http://dx.doi.org/10.1177/0391398818785526DOI Listing
September 2018

Methods for determination of stagnation in pneumatic ventricular assist devices.

Int J Artif Organs 2018 Oct 3;41(10):653-663. Epub 2018 Aug 3.

Division of Medical Apparatus, Institute of Turbomachinery, Lodz University of Technology, Lodz, Poland.

Background: A pneumatic paediatric ventricular assist device developed at the Foundation of Cardiac Surgery Development, Zabrze, equipped with valves based on J. Moll's design, with later modifications introduced at the Institute of Turbomachinery, Lodz University of Technology, was tested numerically and experimentally. The main aim of those investigations was to detect stagnation zones within the ventricular assist device and indicate advantages and limitations of both approaches. Read More

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http://dx.doi.org/10.1177/0391398818790204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159782PMC
October 2018

Past and future of blood damage modelling in a view of translational research.

Int J Artif Organs 2018 Aug 3:391398818790343. Epub 2018 Aug 3.

Institute for Computational and Imaging Science in Cardiovascular Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Anatomic pathologies such as stenosed or regurgitating heart valves and artificial organs such as heart assist devices or heart valve prostheses are associated with non-physiological flow. This regime is associated with regions of spatially high-velocity gradients, high-velocity and/or pressure fluctuations as well as neighbouring regions with stagnant flow associated with high residence time. These hemodynamic conditions cause destruction and/or activation of blood components and their accumulation in regions with high residence time. Read More

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http://dx.doi.org/10.1177/0391398818790343DOI Listing
August 2018
12 Reads

Video capsule endoscopy is safe and effective in suspected small bowel bleeding among left ventricular assist device recipients.

Int J Artif Organs 2018 Dec 3;41(12):833-837. Epub 2018 Aug 3.

1 Gastroenterology Department, Rabin Medical Center, Petah Tikva, Israel.

Introduction:: Suspected small bowel bleeding is frequently encountered in left ventricular assist device recipients and the identification of the culprit lesion may be challenging. Data regarding the safety and yield of small bowel capsule in the investigation of suspected small bowel bleeding are limited. We aimed to evaluate the safety and efficacy of small bowel video capsule endoscopy for the investigation of suspected small bowel bleeding among left ventricular assist device recipients. Read More

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http://journals.sagepub.com/doi/10.1177/0391398818790205
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http://dx.doi.org/10.1177/0391398818790205DOI Listing
December 2018
7 Reads

Susceptibility of density-fractionated erythrocytes to subhaemolytic mechanical shear stress.

Int J Artif Organs 2018 Aug 3:391398818790334. Epub 2018 Aug 3.

1 Biorheology Research Laboratory, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.

Introduction: Accumulating evidence demonstrates that subhaemolytic mechanical stresses, typical of circulatory support, induce physical and biochemical changes to red blood cells. It remains unclear, however, whether cell age affects susceptibility to these mechanical forces. This study thus examined the sensitivity of density-fractionated red blood cells to sublethal mechanical stresses. Read More

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http://dx.doi.org/10.1177/0391398818790334DOI Listing
August 2018
12 Reads

Microhardness and water solubility of expired and non-expired shelf-life composites.

Int J Artif Organs 2018 Jul 30:391398818790626. Epub 2018 Jul 30.

2 Faculty of Dentistry, Bezmialem Vakif University, İstanbul, Turkey.

Background: The aim of this study was to determine the Vickers hardness and water solubility of expired and non-expired shelf-life bulk-fill and conventional dental composite material.

Methods: Four different expired (E) (after 6 months) and non-expired (N) shelf-life composite resin materials (Clearfil Majesty ES-2 Enamel, Clearfil Majesty ES-2 Dentin, Tetric N-Ceram Bulk-Fill, and Tetric N-Ceram) were used. For each tested material, seven specimens were prepared and polymerized with a light curing unit. Read More

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http://dx.doi.org/10.1177/0391398818790626DOI Listing
July 2018
1 Read

Cytotoxicity of long-term denture base materials.

Int J Artif Organs 2018 Oct 22;41(10):677-683. Epub 2018 Jul 22.

3 Department of Biology, Faculty of Science, Hacettepe University, Ankara, Turkey.

Introduction: The aim of this study was to evaluate the cytotoxic effect of various denture base materials following four different aging periods.

Methods: In total, 48 disc-shaped specimens per each group were prepared: Group I: acrylic resin polymerized in cool water and heated up to 100°C over 45 min and boiled for 15 min; Group II: acrylic resin polymerized under pressure in 40°C-45°C water bath for 10 min; Group III: autopolymerized hard relining resin Cold Liner Rebase; Group IV: autopolymerized hard relining resin Truliner; Group V: soft relining resin DentuSil. Then the specimens were stored in water for 24 h or 15 days, or thermocycled 2500 times or 10,000 times. Read More

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http://dx.doi.org/10.1177/0391398818786884DOI Listing
October 2018
13 Reads

Experimental investigations of the aerated polymethylmethacrylate-based vertebral cement flow in capillaries.

Int J Artif Organs 2018 Oct 18;41(10):670-676. Epub 2018 Jul 18.

Institute of Turbomachinery, Lodz University of Technology, Lodz, Poland.

Introduction: A constant growth in the population suffering from osteoporotic vertebral weakening is observed. As a result, vertebroplasty procedures become more and more common. Unfortunately, they may be associated with several complications occurring during bone cement injection, including its leakage or overheating of tissues. Read More

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http://dx.doi.org/10.1177/0391398818786892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159781PMC
October 2018

In vitro study for the evaluation of transluminal aspiration as a novel treatment option for thrombosis in the HeartWare HVAD.

Int J Artif Organs 2018 Nov 18;41(11):764-771. Epub 2018 Jul 18.

1 Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.

Introduction:: Pump thrombosis of left ventricular assist devices remains a devastating complication with high morbidity and mortality. Despite the improvements made, the matter affects many patients and the treatment options are limited to thrombolysis and surgical replacement. An alternative approach using the aspiration Indigo catheter was tested. Read More

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http://dx.doi.org/10.1177/0391398818785557DOI Listing
November 2018
3 Reads

Predictors of red blood cell transfusion and its association with prognosis in patients undergoing extracorporeal membrane oxygenation.

Int J Artif Organs 2018 Oct 12;41(10):644-652. Epub 2018 Jul 12.

1 Réanimation Polyvalente, Centre Hospitalier Universitaire Félix Guyon, Saint-Denis, France.

Purpose: Few data are available on the potential benefits and risks of red blood cell transfusion in patients undergoing extracorporeal membrane oxygenation. The aim of this study was to identify the determinants and prognosis of red blood cell transfusion in patients undergoing extracorporeal membrane oxygenation, with a special focus on biological parameters during extracorporeal membrane oxygenation treatment.

Methods: We conducted a single-center retrospective cohort study including all consecutive patients who underwent extracorporeal membrane oxygenation between January 2010 and December 2015. Read More

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http://dx.doi.org/10.1177/0391398818785132DOI Listing
October 2018
10 Reads
1 Citation
1.450 Impact Factor