4,507 results match your criteria International Journal of Artificial Organs[Journal]


Air contamination during medical treatment results in deposits of microemboli in the lungs: An autopsy study.

Int J Artif Organs 2019 Apr 11:391398819840363. Epub 2019 Apr 11.

2 Department of Public Health and Clinical Medicine, Faculty of Medicine, Umeå University, Umeå, Sweden.

Introduction: Microbubbles of air may enter into patients during conventional hemodialysis, infusions of fluids, or by injections. The aim of this study was to investigate whether the air that enters the patient during hemodialysis can be detected in the lungs after death, and if so, whether this may be related to tissue damage.

Methods: The material consisted of lung tissue from five chronic hemodialysis patients who died either during (two) or after hemodialysis (range 10 min from start until 3333 min after the last hemodialysis session); as reference group tissue was taken from seven patients who died due to amyotrophic lateral sclerosis. Read More

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http://dx.doi.org/10.1177/0391398819840363DOI Listing
April 2019
1 Read

CytoSorb hemoadsorption and mechanical circulatory support in a newborn with refractory shock after congenital heart surgery.

Int J Artif Organs 2019 Apr 10:391398819837539. Epub 2019 Apr 10.

3 Paediatric Cardiology Unit, Department of Paediatrics, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Refractory cardiogenic and vasoplegic shock after congenital heart surgery is a threatening condition leading to high morbidity and mortality. Control of hemodynamic and inflammatory response is fundamental in medical strategy. We report the case of a newborn with cardiogenic and vasoplegic shock secondary to cardiopulmonary bypass for atrioseptostomy and prostaglandin treatment in the context of hypoplastic left heart syndrome, successfully treated with a combination of mechanical circulatory support and cytokine hemoadsorption column (CytoSorb). Read More

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http://dx.doi.org/10.1177/0391398819837539DOI Listing
April 2019
1 Read

Tissue engineering in periodontology: Biological mediators for periodontal regeneration.

Int J Artif Organs 2019 May 2;42(5):241-257. Epub 2019 Apr 2.

1 Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Milano, Italy.

Teeth and the periodontal tissues represent a highly specialized functional system. When periodontal disease occurs, the periodontal complex, composed by alveolar bone, root cementum, periodontal ligament, and gingiva, can be lost. Periodontal regenerative medicine aims at recovering damaged periodontal tissues and their functions by different means, including the interaction of bioactive molecules, cells, and scaffolds. Read More

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http://dx.doi.org/10.1177/0391398819828558DOI Listing
May 2019
1.448 Impact Factor

Hemoadsorption in isolated conjugated hyperbilirubinemia after extracorporeal membrane oxygenation support. Cholestasis of sepsis: A case report and review of the literature on differential causes of jaundice in ICU patient.

Int J Artif Organs 2019 May 28;42(5):263-268. Epub 2019 Mar 28.

1 II Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Lublin, Poland.

Hyperbilirubinemia occurs in up to 40% of critically ill. In ICU, hyperbilirubinemia is an independent factor that influences patients' morbidity and mortality. Jaundice can reflect the course of disease or be caused by treatment (e. Read More

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http://dx.doi.org/10.1177/0391398819834012DOI Listing
May 2019
5 Reads

Impact of preoperative extracorporeal life support on left ventricular assist device outcomes: A comparative study.

Int J Artif Organs 2019 Mar 28:391398819837696. Epub 2019 Mar 28.

1 Department of Cardiac Surgery, European Medical School Oldenburg-Groningen, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Background:: To investigate whether preoperative short-term extracorporeal life support therapy in patients undergoing continuous-flow left ventricular assist device implantation has an impact on the outcome regarding survival and adverse events.

Methods:: Between January 2011 and May 2018, 100 consecutive patients received HeartMate II, HeartWare, or HeartMate III for end-stage heart failure. Mean age was 64. Read More

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http://dx.doi.org/10.1177/0391398819837696DOI Listing
March 2019
2 Reads

Additional hemoperfusion is associated with improved overall survival and self-reported sleep disturbance in patients on hemodialysis.

Int J Artif Organs 2019 Mar 28:391398819837546. Epub 2019 Mar 28.

1 Division of Nephrology, Shanghai Pudong Hospital, Fudan University, Pudong Medical Center, Shanghai, China.

Introduction:: Patients with maintenance hemodialysis have experienced long-standing sleep disturbance. In this study, we attempted to explore whether long-term hemoperfusion could improve sleep and increase the overall survival in hemodialysis patients.

Methods:: A total of 158 patients, who underwent routine hemodialysis, were assessed in this study. Read More

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http://journals.sagepub.com/doi/10.1177/0391398819837546
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http://dx.doi.org/10.1177/0391398819837546DOI Listing
March 2019
3 Reads
1.448 Impact Factor

Solutes removal characteristics at various effluent rates during different continuous renal replacement therapy modalities.

Int J Artif Organs 2019 Mar 25:391398819836045. Epub 2019 Mar 25.

1 Division of Nephrology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai, China.

Background:: Some studies suggest the effluent as a surrogate solute removal indicator in continuous hemodialysis or hemofiltration, but the delivered clearance is frequently smaller than prescribed. This study aims at testing whether the effluent, represented by mL/kg/h, could measure solute clearance and whether increasing effluent increases clearance proportionately in continuous hemodialysis or hemofiltration.

Methods:: Patients treated with continuous renal replacement therapy for various diagnoses were included. Read More

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http://dx.doi.org/10.1177/0391398819836045DOI Listing

Bone repair scaffold coated with bone morphogenetic protein-2 for bone regeneration in murine calvarial defect model: Systematic review and quality evaluation.

Int J Artif Organs 2019 Mar 25:391398819834944. Epub 2019 Mar 25.

1 Department of Orthopaedics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, P.R. China.

To systematically assess the effects of hydroxyapatite bone repair scaffold coated with bone morphogenetic protein-2 on murine calvarial defect models and to determine the quality of studies according to the Animal Research Reporting in In Vivo Experiments guidelines. Internet search was performed in duplicate using PubMed, MEDLINE, Ovid and Embase databases (without restrictions on publication date). The Animal Research Reporting in In Vivo Experiments guidelines were used to evaluate the quality of selected studies. Read More

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http://dx.doi.org/10.1177/0391398819834944DOI Listing

Blood damage in ventricular assist devices.

Int J Artif Organs 2019 Mar;42(3):111-112

3 Biofluid Mechanics Laboratory, Charité - Universitaetsmedizin Berlin, Germany.

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http://dx.doi.org/10.1177/0391398819834736DOI Listing

Flow rate estimation of a centrifugal blood pump using the passively stabilized eccentric position of a magnetically levitated impeller.

Int J Artif Organs 2019 Mar 11:391398819833372. Epub 2019 Mar 11.

2 Department of Mechanical Engineering, Ibaraki University, Hitachi, Japan.

Flow rate estimation for ventricular assist devices without additional flow sensors can improve the quality of life of patients. In this article, a novel flow estimation method using the passively stabilized displacement of a magnetically levitated impeller is developed to achieve sufficient accuracy and precision of flow estimation for ventricular assist devices in a simple manner. The magnetically levitated impeller used is axially suspended by a magnetic bearing in a centrifugal blood pump that has been developed by our group. Read More

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http://dx.doi.org/10.1177/0391398819833372DOI Listing

Noninvasive assessment of blood pressure in rotary blood pump recipients using a novel ultrasonic Doppler method.

Int J Artif Organs 2019 May 11;42(5):226-232. Epub 2019 Mar 11.

1 Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.

In rotary blood pump recipients with low blood pressure pulsatility, current oscillometric methods to measure blood pressure are not applicable. The aim of this study was to use ultrasonic Doppler flow measurements to determine blood pressure in this patient population noninvasively. In 28 rotary blood pump recipients, blood pressure was measured three times with the developed Doppler method and compared to the invasive arterial line (n = 15) or to the oscillometric Terumo Elemano BP monitor (n = 13). Read More

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http://dx.doi.org/10.1177/0391398819833371DOI Listing

Tissue-engineered solution containing cells and biomaterials-an in vitro study: A perspective as a novel therapeutic application.

Int J Artif Organs 2019 Mar 6:391398819833383. Epub 2019 Mar 6.

1 Programa de Pós-Graduação em Ciências da Saúde-Ginecologia e Obstetrícia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brasil.

Some biomaterial scaffolds can positively interfere with tissue regeneration and are being developed to successfully repair the tissue function. The possibility of using epithelial cells combined with biomaterials appears to be a new option as therapeutic application. This combination emerges as a possibility for patients with Mayer-Rokitansky-Kuster-Hauser syndrome which requires vaginal repair and can be performed with tissue-engineered solution containing cells and biomaterials. Read More

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http://dx.doi.org/10.1177/0391398819833383DOI Listing
March 2019
2 Reads
1.448 Impact Factor

Clindamycin clearance during Cytosorb hemoadsorption: A case report and pharmacokinetic study.

Int J Artif Organs 2019 May 28;42(5):258-262. Epub 2019 Feb 28.

1 Adult Intensive Care Unit, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

Panton-Valentine leucocidin producing methicillin-resistant Staphylococcus aureus infections are rare but associated with very high mortality rates. We report the case of a 14-year-old patient with Panton-Valentine leucocidin producing methicillin-resistant Staphylococcus aureus infection and Influenza B pneumonia requiring veno-arterial extra-corporeal membrane oxygenator for refractory shock. In the absence of response to conventional therapy, we have inserted a Cytosorb® cartridge within the extra-corporeal membrane oxygenator circuit. Read More

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http://dx.doi.org/10.1177/0391398819831303DOI Listing
May 2019
1 Read

Propofol-based sedation does not negatively influence oxygenator running time compared to midazolam in patients with extracorporeal membrane oxygenation.

Int J Artif Organs 2019 May 28;42(5):233-240. Epub 2019 Feb 28.

1 Department of Medicine I, Intensive Care Unit 13i2, Medical University of Vienna, Vienna, Austria.

Objective: Patients on extracorporeal membrane oxygenation are frequently in need for sedation. Use of propofol has been associated with impaired oxygenator function due to adsorption to the membrane as well as lipid load. The aim of our retrospective analysis was to compare two different sedation regimens containing either propofol or midazolam with respect to oxygenator running time. Read More

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http://dx.doi.org/10.1177/0391398819833376DOI Listing
May 2019
3 Reads

Comparison of intraoperative versus intraoperative plus postoperative hemoadsorption therapy in cardiac surgery patients with endocarditis.

Int J Artif Organs 2019 Apr 25;42(4):194-200. Epub 2019 Feb 25.

Cardio-Surgical Intensive Care Unit, Cardiovascular Centre, Albertinen-Hospital, Hamburg, Germany.

Infective endocarditis is caused by a bacterial infection of the endocardial surface, and despite improvements in surgical interventions and antimicrobial therapy, mortality remains high. Recently published data suggest that intraoperative hemoadsorption therapy might represent a promising treatment option; however, randomized data still lack, and a comparative study on the intraoperative versus intraoperative plus postoperative use of CytoSorb has not yet been performed. We hypothesized that patients developing intraoperative renal failure benefit from additional postoperative CytoSorb treatment in terms of outcome. Read More

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http://dx.doi.org/10.1177/0391398819831301DOI Listing
April 2019
4 Reads

Expansion of mouse hematopoietic stem/progenitor cells in three-dimensional cocultures on growth-suppressed stromal cell layer.

Int J Artif Organs 2019 Feb 12:391398819827596. Epub 2019 Feb 12.

Department of Biomedical Engineering, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

With the aim of establishing an effective method to expand hematopoietic stem/progenitor cells for application in hematopoietic stem cell transplantation, we performed ex vivo expansion of hematopoietic stem/progenitor cells derived from mouse fetal liver cells in three-dimensional cocultures with stromal cells. In these cocultures, stromal cells were first cultured within three-dimensional scaffolds to form stromal layers and then fetal liver cells containing hematopoietic cells were seeded on these scaffolds to expand the hematopoietic cells over the 2 weeks of coculture in a serum-containing medium without the addition of cytokines. Prior to coculture, stromal cell growth was suppressed by treatment with the DNA synthesis inhibitor mitomycin C, and its effect on hematopoietic stem/progenitor cell expansion was compared with that in control cocultures in which fetal liver cells were cocultured with three-dimensional freeze-thawed stromal cells. Read More

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http://dx.doi.org/10.1177/0391398819827596DOI Listing
February 2019

The positive influence of psychological intervention on the level of anxiety and depression in dialysis patients: A pilot study.

Int J Artif Organs 2019 Apr 25;42(4):167-174. Epub 2019 Jan 25.

University of Warsaw, Warsaw, Poland.

Medical progress in dialysis therapy made it possible to treat patients with the end-stage renal disease for many years. But at the other side it may lead to profound changes in everyday life and may induce depression and anxiety. The research presented in this article explores the influence of psychological interventions on anxiety and depression levels in patients undergoing dialysis therapy. Read More

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http://dx.doi.org/10.1177/0391398818823765DOI Listing

Risk factors for adverse outcomes after left ventricular assist device implantation and extracorporeal cardiopulmonary resuscitation.

Int J Artif Organs 2019 Apr 17;42(4):207-211. Epub 2019 Jan 17.

1 Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany.

Left ventricular assist device implantation following extracorporeal cardiopulmonary resuscitation has been associated with ambivalent results. In a series of patients who underwent left ventricular assist device implantation after extracorporeal cardiopulmonary resuscitation, we investigated whether the outcome can be predicted by preoperative risk factors or established risk scores. Primary endpoint was a composite of mortality and severe neurological disabling over 1 year of follow-up. Read More

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http://dx.doi.org/10.1177/0391398818817327DOI Listing
April 2019
1 Read

A pilot study investigating the effect of pedalling exercise during dialysis on 6-min walking test and hand grip and pinch strength.

Int J Artif Organs 2019 Apr 14;42(4):161-166. Epub 2019 Jan 14.

UCL Department of Nephrology, Royal Free Hospital, UCL Medical School, University College London, London, UK.

Introduction:: Haemodialysis patients are at an increased risk of sarcopenia. Physical inactivity is now recognised as a major cause of muscle wasting in haemodialysis patients. It is unclear as to what and how much exercise is required to show benefit. Read More

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http://dx.doi.org/10.1177/0391398818823761DOI Listing
April 2019
3 Reads

Antibody-mediated rejection after cardiac transplant: Treatment with immunoadsorption, intravenous immunoglobulin, and anti-thymocyte globulin.

Int J Artif Organs 2019 Jan 14:391398818823763. Epub 2019 Jan 14.

1 Department of Cardiovascular Surgery, Heinrich-Heine University Hospital, Düsseldorf, Germany.

Antibody-mediated rejection of allograft is a poorly understood problem after cardiac transplantation that complicates the postoperative course and impairs the graft function and overall survival. Although plasmapheresis and intravenous immunoglobulins have been used as standard therapies for years, there is no consensus about antibody-mediated rejection therapy and most transplantation centers have their own protocols. We describe herein a successful treatment for an acute antibody-mediated rejection of cardiac allograft combining immunoadsorption, intravenous immunoglobulins, and anti-thymocyte globulin, which manifested with polymorphic ventricular tachycardia and right ventricular dysfunction. Read More

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http://dx.doi.org/10.1177/0391398818823763DOI Listing
January 2019
2 Reads

A new hydrophilic polysulfone hemodialysis membrane can prevent platelet-neutrophil interactions and successive neutrophil activation.

Int J Artif Organs 2019 Apr 14;42(4):175-181. Epub 2019 Jan 14.

1 Pharmaceutical Research Laboratories, Toray Industries, Inc., Kamakura, Japan.

Purpose:: Microaggregates have often been observed during hemodialysis and are clearly associated with complications of hemodialysis therapy. In this study, we aimed to clarify the effects of two polysulfone membranes, with different abilities to activate blood cells, on the formation of these microaggregates; we also investigated their molecular mechanisms.

Methods:: Human whole blood was circulated through a mini-module dialyzer using the membranes in vitro; platelet-neutrophil complexes in blood were determined by flow cytometry. Read More

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http://dx.doi.org/10.1177/0391398818823767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421590PMC
April 2019
2 Reads

Clinical effects of hemoadsorption with CytoSorb in patients with severe acute pancreatitis: A case series.

Int J Artif Organs 2019 Apr 14;42(4):190-193. Epub 2019 Jan 14.

3 "Dan Setlacec" Center of Gastrointestinal Disease and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania.

Hemoadsorption using CytoSorb has recently gained attention as a new therapy aimed at modulating the inflammatory response syndrome in critically ill patients. The aim of our study was to assess the clinical effects of CytoSorb in patients with severe acute pancreatitis. We prospectively included 12 patients admitted to the intensive care unit for severe acute pancreatitis. Read More

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http://journals.sagepub.com/doi/10.1177/0391398818823762
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http://dx.doi.org/10.1177/0391398818823762DOI Listing
April 2019
5 Reads

Ventricular assist device in a patient with congenitally corrected transposition of the great arteries and situs inversus totalis.

Int J Artif Organs 2019 Jan 10:391398818823768. Epub 2019 Jan 10.

1 Clinic of Cardiovascular Surgery, Heinrich Heine University Dusseldorf, Dusseldorf, Germany.

Congenitally corrected transposition of the great arteries and situs inversus totalis are rare congenital anomalies. While congenital heart diseases affect about 0.75%-0. Read More

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http://dx.doi.org/10.1177/0391398818823768DOI Listing
January 2019
3 Reads

Numerical investigation of the influence of a bearing/shaft structure in an axial blood pump on the potential for device thrombosis.

Int J Artif Organs 2019 Apr 10;42(4):182-189. Epub 2019 Jan 10.

1 School of Energy and Power Engineering, Beihang University, Beijing, China.

Adverse events caused by flow-induced thrombus formation around the bearing/shaft of an axial blood pump remain a serious problem for axial blood pumps. Moreover, excessive anticoagulation with thrombosis around the bearing potentially increases the risk of postoperative gastrointestinal bleeding. The purpose of this study is to analyze the influence of the bearing structure on the thrombosis potential of an axial blood pump. Read More

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http://dx.doi.org/10.1177/0391398818823769DOI Listing
April 2019
4 Reads

Mechanical circulatory support: 60 years of evolving knowledge.

Authors:
Amedeo Terzi

Int J Artif Organs 2019 May 8;42(5):215-225. Epub 2019 Jan 8.

UOS Chirurgia dei Trapianti, ASST Papa Giovanni XXIII, Bergamo, Italy.

Since the 1950s when the first devices for mechanical circulatory support were developed, there has been an impressive evolution of their technology. The first pioneering pumps were used to rescue acute complications after cardiac surgery. Advances in technology, increased knowledge of flow dynamics, and a more appropriate selection of the patients who actually need this support have contributed to significantly improve the benefits of this therapy. Read More

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http://journals.sagepub.com/doi/10.1177/0391398818822267
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http://dx.doi.org/10.1177/0391398818822267DOI Listing
May 2019
11 Reads

First successful hemoadsorption using CytoSorb® in a septic pediatric patient in Kazakhstan: A case report.

Int J Artif Organs 2019 Jan 7:391398818819953. Epub 2019 Jan 7.

1 National Research Center for Maternal and Child Health, Astana, Kazakhstan.

Purpose:: For the first time in Kazakhstan, we have used a combined extracorporeal support, by including the CytoSorb system in a continuous veno-venous hemofiltration system in an 8-month-old patient with a body weight of 5600 g.

Results:: The CytoSorb therapy session resulted in a reduction of inflammation markers IL-6, S100, procalcitonin, and C-reactive protein. Simultaneously, the level of transaminases, creatine kinase, and troponin were normalized, by the end of the session patient hemodynamics were stable and there was no need for vasopressors, acid-base balance was maintained, and the patient was weaned from mechanical ventilation to spontaneous breathing. Read More

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http://dx.doi.org/10.1177/0391398818819953DOI Listing
January 2019
15 Reads

Amnion-derived mesenchymal stem cells improve viability of endothelial cells exposed to shear stress in ePTFE grafts.

Int J Artif Organs 2019 Feb 26;42(2):80-87. Epub 2018 Dec 26.

1 Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.

Purpose:: Blood vessel reconstruction is an increasing need of patients suffering from cardiovascular diseases. For the development of microvascular prostheses, efficient endothelialization is mandatory to prevent graft occlusion. Here, we assessed the impact of amnion-derived mesenchymal stem/stromal cells (hAMSC), known for their important angiogenic potential, on the integrity and stability of endothelial cells exposed to shear stress in vascular grafts. Read More

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http://dx.doi.org/10.1177/0391398818815470DOI Listing
February 2019
1 Read

Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use.

Int J Artif Organs 2019 Mar 26;42(3):133-142. Epub 2018 Dec 26.

1 Swansea University Medical School, Swansea, UK.

Heart failure remains a disease of ever increasing prevalence in the modern world. Patients with end-stage heart failure are being referred increasingly for mechanical circulatory support. Mechanical circulatory support can assist patients who are ineligible for transplant and stabilise eligible patients prior to transplantation. Read More

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http://dx.doi.org/10.1177/0391398818817326DOI Listing
March 2019
15 Reads

It keeps on turning: Effects of prolonged long-term left ventricular assist device support as a bridge to heart transplantation.

Int J Artif Organs 2019 Feb 24;42(2):65-71. Epub 2018 Dec 24.

1 Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, Middlesex, UK.

Objectives:: Increasing incidence of end-stage heart failure has moved the therapy with left ventricular assist devices to the forefront of surgical treatment. Moreover, continuous sophistication in this technology has resulted in increasing proportion of patients on prolonged support. Early and late complications after left ventricular assist device as a bridge to transplantation and present factors associated with long-term support and long-term outcomes of patients supported for at least 1 year were compared. Read More

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http://dx.doi.org/10.1177/0391398818815471DOI Listing
February 2019
4 Reads

Transient power elevation during iron dextran infusion in a patient with a continuous-flow left ventricular assist device.

Int J Artif Organs 2018 Dec 16:391398818818565. Epub 2018 Dec 16.

6 Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH, USA.

Anemia is common in patients with mechanical circulatory support and is associated with increased morbidity. Repletion using parenteral iron infusions has been proven to be beneficial in patients with heart failure. In this report, we describe a case of increased power and flows of continuous-flow left ventricular assist device (LVAD) during an iron dextran infusion. Read More

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http://dx.doi.org/10.1177/0391398818818565DOI Listing
December 2018
4 Reads

In vitro removal of anti-infective agents by a novel cytokine adsorbent system.

Int J Artif Organs 2019 Feb 13;42(2):57-64. Epub 2018 Dec 13.

1 Department of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Objectives:: The aim of this study is to describe the in vitro adsorption of anti-infective drugs onto an extracorporeal cytokine adsorber.

Methods:: Various anti-infective drugs (β-lactams, quinolones, aminoglycosides, glycopeptides, azole antimycotics) were prepared in normal saline 0.9% and human albumin 5%, and pumped through a cytokine cartridge (CytoSorb; CytoSorbents Corporation, Monmouth Junction, NJ, USA) at a flow rate of 1. Read More

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http://journals.sagepub.com/doi/10.1177/0391398818812601
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http://dx.doi.org/10.1177/0391398818812601DOI Listing
February 2019
3 Reads

Bloodstream infections during post-cardiotomy extracorporeal membrane oxygenation: Incidence, risk factors, and outcomes.

Int J Artif Organs 2018 Dec 11:391398818817325. Epub 2018 Dec 11.

2 ECMO Team, IRCCS Policlinico San Donato, Milan, Italy.

Introduction:: Veno-arterial extracorporeal membrane oxygenation after heart surgery is a relatively common procedure. It is easily applicable but associated with a number of complications, including bloodstream infections. The aim of this study is to determine the current rate and the risk factors related to bloodstream infections acquired during post-cardiotomy veno-arterial extracorporeal membrane oxygenation. Read More

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http://dx.doi.org/10.1177/0391398818817325DOI Listing
December 2018
2 Reads

Patient-specific design process and evaluation of a hip prosthesis femoral stem.

Int J Artif Organs 2018 Dec 11:391398818815479. Epub 2018 Dec 11.

5 Department of Mechanical and Control Engineering, Tokyo Institute of Technology, Tokyo, Japan.

Introduction:: There are several commercially available hip implant systems. However, for some cases, custom implant designed based on patient-specific anatomy can offer the patient the best available implant solution. Currently, there is a growing trend toward personalization of medical implants involving additive manufacturing into orthopedic medical implants' manufacturing. Read More

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http://journals.sagepub.com/doi/10.1177/0391398818815479
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http://dx.doi.org/10.1177/0391398818815479DOI Listing
December 2018
20 Reads

Development of exercise-related values in heart failure patients supported with a left ventricular assist device.

Int J Artif Organs 2019 Apr 6;42(4):201-206. Epub 2018 Dec 6.

1 Schüchtermann-Klinik Bad Rothenfelde, Bad Rothenfelde, Germany.

Following implantation of a left ventricular assist device, the build-up and long-term maintenance of adequate exercise capacity and functional performance become crucial. The aim of this study was to observe the development of exercise-related values at different times, as well as to detect possible influencing factors. We performed a prospective single-centre study: 10 patients (63 years, 100% male, body mass index = 27. Read More

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http://dx.doi.org/10.1177/0391398818815492DOI Listing
April 2019
7 Reads

Antithrombotic properties of hemofilter coated with polymer having a hydrophilic blood-contacting layer.

Int J Artif Organs 2019 Feb 29;42(2):88-94. Epub 2018 Nov 29.

1 Department of Medical Engineering, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan.

Objective:: Extracorporeal circulation devices are coated with a biocompatible polymer coating agent (BPCA) that has a hydrophilic blood-contacting layer, but hemofilters are not. We aimed to investigate the antithrombotic properties of a BPCA-coated hemofilter.

Methods:: Four experiments using BPCA-coated circuits and non-coated hemofilters and four experiments using BPCA-coated circuits and BPCA-coated hemofilters were performed with whole human blood and compared by measuring the circuit pressure every 5 min, antithrombin activity every 40 min, and thrombin-antithrombin complex every 40 min, for a total of 240 min of recirculation. Read More

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http://dx.doi.org/10.1177/0391398818815480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343425PMC
February 2019
11 Reads

Development of a simvastatin loaded injectable porous scaffold in situ formed by phase inversion method for bone tissue regeneration.

Int J Artif Organs 2019 Feb 28;42(2):72-79. Epub 2018 Nov 28.

4 Department of Animal and Marine Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.

Introduction:: The use of injectable scaffolds as a minimally invasive method is a good choice in tissue engineering applications. A critical parameter for the tissue engineering scaffolds is a suitable morphology with interconnected pores. We present the development of a simvastatin loaded scaffold that forms in situ and provides the porous structure with interconnected pores. Read More

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http://dx.doi.org/10.1177/0391398818806161DOI Listing
February 2019
1 Read

Successful decellularization of thick-walled tissue: Highlighting pitfalls and the need for a multifactorial approach.

Int J Artif Organs 2019 Jan 16;42(1):17-24. Epub 2018 Nov 16.

Department of Cardiac Surgery, Laboratory for Tissue Engineering, Grosshadern Medical Centre, Ludwig-Maximilians-University, Munich, Germany.

Introduction:: Decellularization of thick tissue is challenging and varying. Therefore, we tried to establish a multifactorial approach for reliable aortic wall decellularization.

Methods:: Porcine aortic walls were decellularized according to different procedures. Read More

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http://dx.doi.org/10.1177/0391398818805624DOI Listing
January 2019
8 Reads

A new dynamic model for in vitro evaluation of intravascular devices.

Int J Artif Organs 2019 Jan 4;42(1):42-48. Epub 2018 Nov 4.

2 Department of Cardiac Surgery, Ghent University Hospital (UZ Gent), Gent, Belgium.

Introduction:: A dynamic model to evaluate thrombus formation on intravascular catheters in vitro is presented. The model enables fluid infusion, variation in the catheter orientation, and variable flow conditions. It was applied on a catheter used to shunt cerebrospinal fluid to a vein, a dural venous sinus, for the treatment of hydrocephalus. Read More

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http://dx.doi.org/10.1177/0391398818806158DOI Listing
January 2019
15 Reads

Impact of setup orientation on blend electrospinning of poly-ε-caprolactone-gelatin scaffolds for vascular tissue engineering.

Int J Artif Organs 2018 Nov;41(11):801-810

Institute for Multiphase Processes, Leibniz University Hannover, Hannover, Germany.

Introduction:: This article explores the effect of horizontal and vertical setups on blend electrospinning with two polymers having vastly different properties - poly-ε-caprolactone and gelatin, and subsequent effect of the resulting microstructure on viability of seeded cells.

Methods:: Poly-ε-caprolactone and gelatin of varying blend concentrations were electrospun in horizontal and vertical setup orientations. NIH 3T3 fibroblasts were seeded on these scaffolds to assess cell viability changes in accordance with change in microstructure. Read More

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http://dx.doi.org/10.1177/0391398818803478DOI Listing
November 2018
7 Reads

Chondrocytes cultured in silk-based biomaterials maintain function and cell morphology.

Int J Artif Organs 2019 Jan 30;42(1):31-41. Epub 2018 Oct 30.

5 NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China.

Objective:: To characterize the morphology of chondrocytes and the expression and secretion of active collagen II by these cells cultured within a regenerated silk fibroin film. Silk fibroin film cytocompatibility and the effect of silk fibroin on chondrocytes in vitro were also evaluated.

Methods:: Chondrocytes were transfected with a lentivirus containing a green fluorescent protein marker and cultured within a regenerated silk fibroin film. Read More

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http://dx.doi.org/10.1177/0391398818806156DOI Listing
January 2019
8 Reads

Blood damage in Left Ventricular Assist Devices: Pump thrombosis or system thrombosis?

Int J Artif Organs 2019 Mar 24;42(3):113-124. Epub 2018 Oct 24.

1 Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.

Introduction:: Despite significant technical advancements in the design and manufacture of Left Ventricular Assist Devices, post-implant thrombotic and thromboembolic complications continue to affect long-term outcomes. Previous efforts, aimed at optimizing pump design as a means of reducing supraphysiologic shear stresses generated within the pump and associated prothrombotic shear-mediated platelet injury, have only partially altered the device hemocompatibility.

Methods:: We examined hemodynamic mechanisms that synergize with hypershear within the pump to contribute to the thrombogenic potential of the overall Left Ventricular Assist Device system. Read More

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http://journals.sagepub.com/doi/10.1177/0391398818806162
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http://dx.doi.org/10.1177/0391398818806162DOI Listing
March 2019
15 Reads
1.450 Impact Factor

Couette shearing device for the investigation of shear-induced damage of the primary hemostasis by left ventricular assist devices.

Int J Artif Organs 2019 Mar 22;42(3):143-150. Epub 2018 Oct 22.

Biofluid Mechanics Laboratory, Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Introduction:: Continuous-flow left ventricular assist devices have evolved from short-time therapy into permanent or so-called destination therapy. One complication in long-term usage is bleeding, which is presumably attributed to shear-induced interference of left ventricular assist devices with the coagulation system.

Methods:: The influence of dynamic shear stresses on primary hemostasis by single or multiple passes through left ventricular assist devices was investigated. Read More

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http://dx.doi.org/10.1177/0391398818802950DOI Listing
March 2019
20 Reads

Characterization and biological properties of a novel synthesized silicon-substituted hydroxyapatite derived from eggshell.

Int J Artif Organs 2019 Feb 22;42(2):95-108. Epub 2018 Oct 22.

1 Faculty of New Science and Technology, Semnan University, Semnan, Iran.

In the present study, the effect of adding different concentrations of silicon on physical, mechanical and biological properties of a synthesized aqueous precipitated eggshell-derived hydroxyapatite (e-HA) was evaluated. No secondary phases were detected by X-ray diffraction for the specimens e-HA and e-HA containing silicon (Si-e-HAs) before and after heating at 1200°C. A reduction in the crystallite size and a-axis as well as an increase in c-axis was occurred when silicon replacement was happened in the structure of e-HA. Read More

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http://dx.doi.org/10.1177/0391398818806159DOI Listing
February 2019
29 Reads

Does the plasma refilling coefficient change during hemodialysis sessions?

Int J Artif Organs 2018 Nov 2;41(11):706-713. Epub 2018 Oct 2.

1 Department of Modeling and Supporting of Internal Organs Functions, Nalecz Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences, Warsaw, Poland.

The filtration coefficient in the Starling equation is an important determinant of plasma refilling during hemodialysis. A method for calculating from clinical data an estimate of the filtration coefficient, called the refilling coefficient, was proposed in the past. The assumption behind this method was that the only drive for refilling is the increase in plasma oncotic pressure, and the remaining Starling forces have negligible effect. Read More

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http://dx.doi.org/10.1177/0391398818803439DOI Listing
November 2018
16 Reads

Evaluation of pre- and post-dilution continuous veno-venous hemofiltration on leukocyte and platelet function in patients with sepsis.

Int J Artif Organs 2019 Jan 2;42(1):9-16. Epub 2018 Oct 2.

3 Department of Anesthesiology, School of Medicine, Sapporo Medical University, Sapporo, Japan.

Objective:: We investigated the differences in biocompatibility pre- and post-dilution during continuous veno-venous hemofiltration in patients with sepsis, focusing on leukocyte and platelet function.

Patients And Methods:: Subjects were 12 patients with septic shock who underwent veno-venous hemofiltration for acute kidney injury between March 2016 and September 2017. The first six patients received pre-dilution veno-venous hemofiltration, and the next six patients received post-dilution veno-venous hemofiltration. Read More

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http://dx.doi.org/10.1177/0391398818801292DOI Listing
January 2019
10 Reads

Young ESAO challenges in artificial organs.

Int J Artif Organs 2018 11 2;41(11):687-689. Epub 2018 Oct 2.

2 Institute for Multiphase Processes, Leibniz University Hannover, Hannover, Germany.

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http://dx.doi.org/10.1177/0391398818804133DOI Listing
November 2018
2 Reads

Optimal drainage cannula position in dual cannulation for veno-venous extracorporeal membrane oxygenation.

Int J Artif Organs 2018 Dec 17;41(12):867-871. Epub 2018 Sep 17.

2 Department of Artificial Organs, National Cerebral and Cardiovascular Center, Osaka, Japan.

Introduction:: Recently, the use of veno-venous extracorporeal membrane oxygenation for adult patients with severe acute respiratory failure has increased. We previously investigated the optimal return cannula position; however, the optimal drainage cannula position has not yet been fully clarified. The aim of this study was to investigate the optimal drainage cannula position. Read More

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http://dx.doi.org/10.1177/0391398818795357DOI Listing
December 2018
3 Reads

Salvage extracorporeal membrane oxygenation in induction-associated acute respiratory distress syndrome in acute leukemia patients: A case series.

Int J Artif Organs 2019 Jan 17;42(1):49-54. Epub 2018 Sep 17.

3 Trauma/Critical Care Surgery Service, San Antonio Military Medical Center, JBSA Fort Sam Houston, TX, USA.

Background:: The prognosis of hematologic malignancies has improved over the past three decades. However, the prognosis in hematologic malignancies with severe acute respiratory distress syndrome has remained poor. Initial reports regarding the utility of extracorporeal membrane oxygenation in hematologic malignancies have been controversial, with limited evaluations of acute leukemia patients supported by extracorporeal membrane oxygenation. Read More

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http://dx.doi.org/10.1177/0391398818799160DOI Listing
January 2019
26 Reads

Sex-age-specific handgrip strength and mortality in an incident hemodialysis cohort: The risk explained by nutrition and comorbidities.

Int J Artif Organs 2018 Dec 11;41(12):825-832. Epub 2018 Sep 11.

3 Unit of Clinical Epidemiology and Evidence Based Medicine, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Brazil.

Objective:: To investigate associations of sex-age-specific handgrip strength by a dynamometer with all-cause mortality and the percent excess risk explained (%ERE) by comorbidities and nutritional indicators in incident maintenance hemodialysis patients.

Methods:: Prospective cohort of 413 adult patients (165 women, 248 men, 299 <60 years and 114 ⩾60 years) with <6 months (82% <3 months) on dialysis enrolled in PROHEMO in Salvador, Brazil. Low and high handgrip strength groups were based on sex-age-specific cutoffs (17. Read More

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http://dx.doi.org/10.1177/0391398818793088DOI Listing
December 2018
9 Reads

Tubular vesicopyelostomy for the management of types 2 and 3 (long-segment) ureteric stenosis after kidney transplantation.

Int J Artif Organs 2019 Jan 5;42(1):3-8. Epub 2018 Sep 5.

2 Department of Internal Nephrology, University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.

Late ureteral stenosis following kidney transplantation needs immediate correction in order to protect allograft function and requires a complicated surgical procedure. In this study, we present the long-term results of tubular bladder reconfiguration and cystopyelostomy (tubular vesicopyelostomy), an innovative and practical procedure for the management of long-segment ureteric stenosis (types 2 and 3) after transplantation. Between 2002 and 2017, 722 kidney transplant patients were monitored at the University of Medical Sciences, Bozyaka Organ Transplantation and Research Center. Read More

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http://dx.doi.org/10.1177/0391398818796346DOI Listing
January 2019
7 Reads