5,508 results match your criteria International Immunopharmacology[Journal]


Pretreatment with resveratrol ameliorate trigeminal neuralgia by suppressing matrix metalloproteinase-9/2 in trigeminal ganglion.

Int Immunopharmacol 2019 Apr 18;72:339-347. Epub 2019 Apr 18.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China; Department of Pediatric and Preventive Dentistry, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. Electronic address:

Trigeminal neuralgia (TN) is a common type of neuropathic pain whereas the underlying pathogenesis has not been completely elucidated. Recent study suggests that the development of neuroinflammation is responsible for generating and sustaining neuropathic pain. The purpose of our study was to investigate the protective effect of intervening the inflammation in early stages of pain and explore its potential mechanism. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.014DOI Listing

Geniposide, a sonic hedgehog signaling inhibitor, inhibits the activation of hepatic stellate cell.

Int Immunopharmacol 2019 Apr 18;72:330-338. Epub 2019 Apr 18.

Department of Pharmacy, The Second Affiliated Hospital Of Bengbu Medical College, Hongye Road, Bengbu 233000, China. Electronic address:

Liver fibrosis is a continuous wound-healing process, which is due to excessive deposition of extracellular matrix (ECM) caused by activated Hepatic Stellate Cells (HSCs). Geniposide (GP) is a naturally occurring iridoid glucoside and is extracted from Gardenia jasminoides Ellis. GP has long been speculated to play a vital role in the treatment of hyperlipidemia and fatty liver. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.016DOI Listing

New therapeutic strategies based on IL-2 to modulate Treg cells for autoimmune diseases.

Int Immunopharmacol 2019 Apr 18;72:322-329. Epub 2019 Apr 18.

Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 30072, PR China. Electronic address:

Interleukin-2 (IL-2) is a multifunctional cytokine in immune regulation. It is essential for the differentiation, expansion and stability of CD25Foxp3 regulatory T (Treg) cells, which is an important factor in immune suppression and self-tolerance. Meanwhile, IL-2 also stimulate effector T (Teff) cells to promote immune responses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183113
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http://dx.doi.org/10.1016/j.intimp.2019.03.064DOI Listing
April 2019
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Cell wall mannoprotein of Candida albicans polarizes macrophages and affects proliferation and apoptosis through activation of the Akt signal pathway.

Int Immunopharmacol 2019 Apr 17;72:308-321. Epub 2019 Apr 17.

Department of Dermatology, The First Hospital of China Medical University, Shenyang 110001, PR China; Key Lab of Dermatology, Ministry of Education and Public Health, National joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang 110001, PR China. Electronic address:

Candida albicans is a commensal fungus that associates with human hosts. Under normal circumstances this interaction does not produce any severe life-threatening disease, as macrophages of the innate immune system will result in its clearance. However, disorders may arise in immunosuppressed individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193058
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http://dx.doi.org/10.1016/j.intimp.2019.03.032DOI Listing
April 2019
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Oridonin inhibits LPS-induced inflammation in human gingival fibroblasts by activating PPARγ.

Int Immunopharmacol 2019 Apr 17;72:301-307. Epub 2019 Apr 17.

First Clinical Hospital of Harbin Medical University, Harbin 150001, China. Electronic address:

Oridonin, the major terpene isolated from Rabdosia rubescens, has been used as dietary supplement. Recently, it has been known to exhibit anti-inflammatory effect. This study we employed an in vitro model of LPS-stimulated human gingival fibroblasts to investigate the anti-inflammatory effects and mechanism of oridonin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183066
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http://dx.doi.org/10.1016/j.intimp.2019.04.006DOI Listing
April 2019
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Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects.

Int Immunopharmacol 2019 Apr 17;72:292-300. Epub 2019 Apr 17.

Department of Immunology, Medical College of Nanchang University, Nanchang 330000, China. Electronic address:

Curcumin is a natural herbal product that has been popularly used to treat autoimmune diseases in China; however, its effects on rheumatoid arthritis and its mechanism are not clear. The main purposes of this study are to explore the therapeutic effects of curcumin on collagen-induced arthritis (CIA) rats and the pharmacological mechanism. In the present study, CIA rats were established by injecting bovine type II collagen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193079
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http://dx.doi.org/10.1016/j.intimp.2019.04.027DOI Listing
April 2019
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Imiquimod enhances DNFB mediated contact hypersensitivity in mice.

Int Immunopharmacol 2019 Apr 17;72:284-291. Epub 2019 Apr 17.

Department of Immunology, Basic Medical College of Qingdao University, Qingdao 266071, China.

Imiquimod (Imiq) is a synthetic imizoquinoline compound which can act on Toll-like receptor (TLR)7 and transduce signals involved in cell activation. We investigated the role of Imiq on contact hypersensitivity (CHS) and explored the potential mechanisms of mast cells involved in the process. Topical application of Imiq cream augmented DNFB mediated CHS in C57BL/6 mice. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.025DOI Listing
April 2019
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Candida albicans-induced acute lung injury through activating several inflammatory signaling pathways in mice.

Int Immunopharmacol 2019 Apr 17;72:275-283. Epub 2019 Apr 17.

Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; Anhui Center for Surveillance of Bacterial Resistance, Hefei 230032, China. Electronic address:

Candida albicans infection-induced acute lung injury is one of the most prevalent diseases in immunosuppressive individual. Nevertheless, the mechanism by which Candida albicans induced acute lung injury remains unclear. The present study investigated the mechanism by which Candida albicans induced acute lung injury in mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183145
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http://dx.doi.org/10.1016/j.intimp.2019.04.026DOI Listing
April 2019
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Extracellular vesicles derived from bone marrow mesenchymal stem cells attenuate dextran sodium sulfate-induced ulcerative colitis by promoting M2 macrophage polarization.

Int Immunopharmacol 2019 Apr 17;72:264-274. Epub 2019 Apr 17.

Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei, China. Electronic address:

Extracellular vesicles (EVs) secreted by bone marrow mesenchymal stem cells (BMSCs) have shown repairing effects in tissue damage. However, their efficacy and mechanism in the treatment of ulcerative colitis (UC), a type of chronic inflammatory bowel disease, are unclear. To investigate the effects and possible mechanism of EVs in UC treatment, we established an in vitro model using lipopolysaccharide (LPS)-treated macrophages and an in vivo dextran sulfate sodium (DSS)-induced mouse model to mimic UC. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.020DOI Listing
April 2019
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The skeletal renin-angiotensin system: A potential therapeutic target for the treatment of osteoarticular diseases.

Int Immunopharmacol 2019 Apr 16;72:258-263. Epub 2019 Apr 16.

Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, China.

The classical renin-angiotensin system (RAS) is known to be a key regulator of blood pressure as well as fluid and electrolyte homeostasis. Additionally, it is now evident that components of the RAS are produced and act locally in many tissues, including liver, kidney, heart, lung, eye, bone, reproductive organ, adipose, and adrenal tissue, and these components are collectively known as tissue RAS. Recently, several studies have shown that local bone RAS is directly involved in bone metabolism, and activation of skeletal RAS plays an important role in bone diseases, such as osteoporosis, arthritis, and deterioration as well as in fracture healing. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.023DOI Listing
April 2019
2 Reads

The immunomodulatory effect of Poria cocos polysaccharides is mediated by the Ca/PKC/p38/NF-κB signaling pathway in macrophages.

Int Immunopharmacol 2019 Apr 16;72:252-257. Epub 2019 Apr 16.

Department of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Electronic address:

Poria cocos polysaccharide (PCP), extracted from Poria cocos sclerotium, has many biological activities. The present study explored the immunomodulatory effect and the underlying molecular mechanism of PCP in RAW 264.7 macrophages. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.017DOI Listing
April 2019
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Doxycycline alleviates paraquat-induced acute lung injury by inhibiting neutrophil-derived matrix metalloproteinase 9.

Int Immunopharmacol 2019 Apr 16;72:243-251. Epub 2019 Apr 16.

Department of Emergency, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Paraquat (PQ), a highly toxic herbicide, selectively accumulates in the lungs and causes pulmonary damage through oxidative and inflammatory processes after intentional or accidental poisoning. The resulting acute lung injury (ALI) is characterized by neutrophil infiltration and extensive inflammation with rapid respiratory failure. However, effective therapies are lacking. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.015DOI Listing
April 2019
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Effects of batroxobin treatment on the survival of random skin flaps in rats.

Int Immunopharmacol 2019 Apr 16;72:235-242. Epub 2019 Apr 16.

Department of Hand Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, The Second School of Medicine, Wenzhou Medical University, Wenzhou, China. Electronic address:

Objective: Batroxobin is a medicinal preparation extracted from the venom of the Fer-de-Lance snake, and is used to lower blood viscosity, promote blood fibrinogen decomposition, and inhibit thrombosis. This research is to investigate whether batroxobin can improve the survival of random skin flaps in a rat model.

Materials And Methods: Dorsal McFarlane flaps were harvested from 36 rats divided into two groups. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.011DOI Listing

CXCR6 deficiency ameliorates ischemia-reperfusion injury by reducing the recruitment and cytokine production of hepatic NKT cells in a mouse model of non-alcoholic fatty liver disease.

Int Immunopharmacol 2019 Apr 16;72:224-234. Epub 2019 Apr 16.

Department of Hepatic Surgery and Liver Transplantation Center of The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. Electronic address:

Fatty liver is used for transplantation due to organ shortage, but prone to cause complications like ischemia-reperfusion injury (IRI). NKT cells as a bridge between innate and adaptive immunity were reported to infiltrate the liver at the early phase of IRI induced in normal liver. However, the localization mechanism of NKT cells is not precise, and the role of NKT cells in fatty liver IRI is poorly understood. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.021DOI Listing

Therapeutic advances in the treatment of SLE.

Int Immunopharmacol 2019 Apr 16;72:218-223. Epub 2019 Apr 16.

Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, 139 Middle Renmin Road, Changsha, Hunan 410011, China. Electronic address:

In recent years, the research on the pathogenesis of systemic lupus erythematosus (SLE) has been deepened, from the level of histopathology to the cellular and molecular biology, thus promoting the progress of SLE drug therapeutics. In March 2011, the United States Food and Drug Administration (FDA) approved the humanized monoclonal antibody, Belimumab for the treatment of SLE and put an end to the dilemma of no new drug available to SLE for more than half a century. On the other hand, the continuous evidence-based medical information has enabled rheumatologists to have a more comprehensive and depth understanding of the application of SLE traditional therapies, further improve the treatment strategy of SLE and put forward higher requirements for treatment goals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193047
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http://dx.doi.org/10.1016/j.intimp.2019.03.010DOI Listing
April 2019
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Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-κB activation.

Int Immunopharmacol 2019 Apr 15;72:204-210. Epub 2019 Apr 15.

Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address:

Acute pancreatitis (AP) is a common acute abdominal disease with local or systemic inflammatory response, caused by abnormal activation of digestive enzymes. Baicalein has been shown to exert anti-inflammatory effects and to attenuate the pathological changes of AP. The aim of the research was to investigate the effects of baicalein on caerulein induced pancreatitis, and to elucidate the putative underlying mechanism. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.018DOI Listing
April 2019
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Cluster binding studies with two anti-Thomsen-Friedenreich (anti-core-1, CD176, TF) antibodies: Evidence for a multiple TF epitope.

Int Immunopharmacol 2019 Apr 15;72:186-194. Epub 2019 Apr 15.

Glycotope GmbH, 13125 Berlin-Buch, Germany. Electronic address:

Antibodies to carbohydrate epitopes are often of the IgM isotype and require multiple binding for sufficient avidity. Therefore clusters of epitopes are preferred antigenic sites in these cases. We have examined the type of clusters recognized by two anti-Thomsen-Friedenreich (TF, core-1, CD176) IgM antibodies, NM-TF1 and NM-TF2, using several different sets of TF-carrying synthetic glycoconjugates in ELISA experiments. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.058DOI Listing
April 2019
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Inhibition of MRP4 alleviates sepsis-induced acute lung injury in rats.

Int Immunopharmacol 2019 Apr 14;72:211-217. Epub 2019 Apr 14.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Cardiovascular Research Institute, Wuhan University, Wuhan 430060, China. Electronic address:

This study was undertaken to examine the regulatory role of multidrug resistance-associated protein 4 (MRP4) in an experimental model of sepsis-induced acute lung injury in rats. Sepsis was induced by cecal ligation and puncture in anesthetized rats. Animals were then randomly assigned to receive intravenous injection of vehicle or MRP4 inhibitor (MK571, 20 mg/kg). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193026
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http://dx.doi.org/10.1016/j.intimp.2019.04.009DOI Listing
April 2019
7 Reads

Daphnetin prevents methicillin-resistant Staphylococcus aureus infection by inducing autophagic response.

Int Immunopharmacol 2019 Apr 13;72:195-203. Epub 2019 Apr 13.

School of Medicine and Life Science, Nanjing University of Chinese Medicine, Nanjing 210046, China. Electronic address:

The bacterial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA) is a potentially fatal disease, featured with extensive infection, inflammation, and airway dysfunction. With the increasing emerging of drug-resistant strains, new therapeutic strategies beyond canonical antibiotic treatment are pressingly needed. Daphnetin (DAPH) is a natural coumarin derivative with anti-inflammation, anti-microorganism and anti-oxidative properties. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.007DOI Listing
April 2019
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EphA2 antagonism alleviates LPS-induced acute lung injury via Nrf2/HO-1, TLR4/MyD88 and RhoA/ROCK pathways.

Int Immunopharmacol 2019 Apr 12;72:176-185. Epub 2019 Apr 12.

Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China. Electronic address:

Eph receptor tyrosine kinases have a wide range of biological functions and have gradually been recognized increasingly as key regulators of inflammation and injury diseases. Although previous studies suggested that EphA2 receptor may be involved in the regulation of inflammation and vascular permeability in injured lung, the detailed effects of EphA2 on LPS-induced acute lung injury (ALI) are still inadequate and the underlying mechanism remains poorly understood. In this study, we detected the effects of EphA2 antagonism on inflammation, pulmonary vascular permeability and oxidative stress in LPS-induced ALI and investigate the potential mechanism. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.008DOI Listing
April 2019
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Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice.

Int Immunopharmacol 2019 Apr 12;72:166-175. Epub 2019 Apr 12.

Department of Pharmacology, Key Laboratory of Neuropsychiatric Diseases, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Accumulating evidence has shown that tauroursodeoxycholic acid (TUDCA) is neuroprotective in different animal models of neurological diseases. However, whether TGR5 agonist TUDCA can improve lipopolysaccharide (LPS)-induced cognitive impairment in mice is less clear. Using a model of cognitive impairment with LPS (2. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.065DOI Listing

The nitrated fatty acid, 10-nitrooleate inhibits the neutrophil chemotaxis via peroxisome proliferator-activated receptor gamma in CLP-induced sepsis in mice.

Int Immunopharmacol 2019 Apr 10;72:159-165. Epub 2019 Apr 10.

Department of Zoology, Yogi Vemana University, Kadapa 516 005, A.P, India. Electronic address:

The inhibition of polymorphonuclear neutrophils' (PMNs) migration to the source of injury is among the most prominent aspects of immunosuppression following sepsis, although the precise mechanisms involved remain unclear and multifaceted. Increasing evidence connects this immunosuppression to nitric oxide (NO), as NO production is a classic feature of inflammation probably through neutrophil activation and migration. Nitrated fatty acids (NFA) such as 10-nitrooleate (OA-NO), nitrolinoleic acid etc. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.001DOI Listing
April 2019
2.472 Impact Factor

Long non-coding RNA highly up-regulated in liver cancer protects tumor necrosis factor-alpha-induced inflammatory injury by down-regulation of microRNA-101 in ATDC5 cells.

Int Immunopharmacol 2019 Apr 10;72:148-158. Epub 2019 Apr 10.

The Second Hospital of Shandong University, Jinan 250000, China. Electronic address:

Background: Osteoarthritis (OA) is a familiar joint degenerative disease. Long non-coding RNAs (lncRNAs) play vital roles in the pathogenesis of OA. Nevertheless, the regulatory impacts of lncRNA highly up-regulated in liver cancer (lncRNA-HULC) on OA remain dimness. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.004DOI Listing
April 2019
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PPAR-γ agonist pioglitazone protects against IL-17 induced intervertebral disc inflammation and degeneration via suppression of NF-κB signaling pathway.

Int Immunopharmacol 2019 Apr 10;72:138-147. Epub 2019 Apr 10.

Department of Orthopedics, Qilu Hospital of Shandong University, Jinan, China. Electronic address:

Interleukin-17 (IL-17) is the production of T helper type 17 (Th17) cells and has been reported to play a pro-inflammatory role in the immunopathogenesis of intervertebral disc degeneration. Peroxisome proliferator-activated receptor γ (PPAR-γ) activators display anti-inflammatory and anti-degeneration roles in osteoarthritis and rheumatoid arthritis. However, the expression level of PPAR-γ and related regulatory mechanisms in the nucleus pulposus tissues are not clear. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.012DOI Listing

Saikosaponin a ameliorates lipopolysaccharide and d‑galactosamine-induced liver injury via activating LXRα.

Int Immunopharmacol 2019 Apr 10;72:131-137. Epub 2019 Apr 10.

Department of Infectious Diseases, The Fifth Affiliated Hospital SUN YAT-SEN University, Guangzhou, China.

Saikosaponin a (SSa), one of the major active components of Bupleurum falcatum, has antioxidant and anti-inflammatory pharmacological properties. However, the effects of SSa on liver injury have not been reported. In the present study, we evaluated the protective effects and mechanisms of SSa on lipopolysaccharide (LPS)/d‑galactosamine (D-GalN)-induced liver injury. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.049DOI Listing

Daucosterol suppresses dextran sulfate sodium (DSS)-induced colitis in mice.

Int Immunopharmacol 2019 Apr 9;72:124-130. Epub 2019 Apr 9.

Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon 34520, Republic of Korea. Electronic address:

The effects of daucosterol have been identified in cancer therapy and neuronal diseases. However, the regulatory function of daucosterol in DSS-induced colitis has not yet been investigated. In this study, we evaluated the immunological and therapeutic effects of daucosterol in a mouse model of dextran sulfate sodium (DSS)-induced colitis. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.062DOI Listing

Ginsenoside Rg3 improves cyclophosphamide-induced immunocompetence in Balb/c mice.

Int Immunopharmacol 2019 Apr 8;72:98-111. Epub 2019 Apr 8.

State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address:

Ginsenoside Rg3 (Rg3), which comprises Panax ginseng, is commonly used to improve the immunocompetence of cancer patients undergoing chemotherapy. This study was designed to elucidate the immunoenhancement effects of Rg3 in immunosuppressed mice induced by cyclophosphamide (CTX) treatment. Balb/c mice were administered Rg3 intragastrically once daily for 19 consecutive days and were intraperitoneally administered CTX (80 mg/kg) on days 15-19. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.003DOI Listing
April 2019
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Elevated serum CXCL10 in patients with Clostridium difficile infection are associated with disease severity.

Int Immunopharmacol 2019 Apr 8;72:92-97. Epub 2019 Apr 8.

Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Friendship Road, Yuzhong District, Chongqing 400016, China. Electronic address:

Clostridium difficile infection (CDI) is the primary cause of community- and health care-associated diarrhea. CXCL10, also known as IFN-γ-inducible protein of 10 (IP-10), is involved in various inflammatory diseases, but its role in CDI remains unknown. In this study, We determined the serum concentration of CXCL10 in 80 CDI patients and 76 sex & age-matched diarrhea patients by enzyme-linked immunosorbent assay (ELISA) and analyzed the correlation between CXCL10 levels and CDI disease severity parameters. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.033DOI Listing

Alteration of human macrophage phenotypes by the anti-fibrotic drug nintedanib.

Int Immunopharmacol 2019 Apr 8;72:112-123. Epub 2019 Apr 8.

Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France. Electronic address:

The tyrosine kinase inhibitor, Nintedanib (NTD), has been approved for the treatment of idiopathic pulmonary fibrosis (IPF). In cell-free systems, NTD was recently shown to inhibit kinase activity of the human recombinant colony-stimulating factor 1 (CSF1) receptor (CSF1R) which mediates major functions of pulmonary macrophages. In the present study, we have investigated the effects of NTD on the phenotype of human monocyte-derived macrophages controlled by CSF1 in order to identify its anti-inflammatory properties via CSF1R inhibition. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.061DOI Listing
April 2019
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Potent stimulation of eosinopoiesis in murine bone-marrow by myriadenolide is mediated by cysteinyl-leukotriene signaling.

Int Immunopharmacol 2019 Apr 6;72:82-91. Epub 2019 Apr 6.

Dept. of Immunology, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

We describe the potent effect of myriadenolide (Myr), a naturally occurring labdane diterpene, in promoting the production of eosinophils in cultured bone-marrow from several inbred mouse strains. This enhancing effect is lineage-selective and requires the eosinophil growth factors, Interleukin(IL)-5 or GM-CSF. Myr acts over a very low concentration range (10-10 M), if added at the beginning of the cell cultivation. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.002DOI Listing

RhoA inhibitor suppresses the production of microvesicles and rescues high ventilation induced lung injury.

Int Immunopharmacol 2019 Apr 5;72:74-81. Epub 2019 Apr 5.

Department of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi Zhuang Autonomous Region, China.. Electronic address:

Microvesicles (MVs) have been extensively identified in various biological fluids including bronchoalveolar lavage fluid (BALF), peripheral blood and ascitic fluids. Our previous study showed that MVs are responsible for acute lung injury, but the exact mechanism underlying MVs formation remains poorly understood. In the present study, we investigate the potential role of RhoA/Rock signaling in MVs generation and the biological activity of MVs in ventilator-induced lung injury (VILI). Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.059DOI Listing
April 2019
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The role of kinin B and B receptors in the mouse model of oxazolone-induced atopic dermatitis.

Int Immunopharmacol 2019 Apr 5;72:62-73. Epub 2019 Apr 5.

Escola de Ciências, Programa de Pós-Graduação em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, Brazil; Escola de Ciências da Saúde, Centro de Pesquisa em Toxicologia e Farmacologia, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga, 6681, Porto Alegre, RS 90619-900, Brazil; Escola de Ciências da Saúde, Curso de Graduação em Odontologia, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, Brazil; Escola de Medicina, Programa de Pós-Graduação em Medicina e Ciências da Saúde, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, Brazil. Electronic address:

This study evaluated the role of kinin B and B receptors in the pre-clinical mouse model of oxazolone-induced atopic dermatitis. The B R715 or B HOE140 receptor antagonists were dosed at different schemes of treatment. After assessment of clinical lesion scores and pruritus, lesional skin samples were collected for histopathological analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193026
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http://dx.doi.org/10.1016/j.intimp.2019.03.063DOI Listing
April 2019
2 Reads

Vitamin D3 induces the expression of membrane progesterone receptors (mPRs) on naive CD4 T lymphocyte cells in women of reproductive age.

Int Immunopharmacol 2019 Apr 5;72:55-61. Epub 2019 Apr 5.

School of Medicine, Isfahan University of Medical Sciences, Department of Immunology, Isfahan, Iran; Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Objective: Vitamin D3 and progesterone (P4) both belong to steroid hormones. These hormones have effects on the function of each other in different ways. The immunomodulatory activity of vitamin D3 and P4 and their role in inducing maternal tolerance for fetus have been shown in various studies. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.053DOI Listing

Aloin attenuates cognitive impairment and inflammation induced by d-galactose via down-regulating ERK, p38 and NF-κB signaling pathway.

Int Immunopharmacol 2019 Apr 5;72:48-54. Epub 2019 Apr 5.

Fudan University Huashan Hospital, Dept. of Neurosurgery, State Key Laboratory for Medical Neurobiology, Institutes of Brain Science, Shanghai Medical College-Fudan University. 12 Urumqi Zhong Road, Shanghai 200040, China. Electronic address:

Oxidative stress is considered as major culprit for neurodegenerative diseases and triggers cognitive and memory impairments. The present study mainly aimed to study the protective effects and underlying mechanisms of aloin on d-galactose (d-gal) induced ageing mice. Our results demonstrated that chronic administration of d-gal (150 mg kg) in mice caused spontaneous and cognitive impairments, as determined by open-field test and Morris water-maze test. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.050DOI Listing
April 2019
1 Read

CD5L contributes to the pathogenesis of methicillin-resistant Staphylococcus aureus-induced pneumonia.

Int Immunopharmacol 2019 Apr 5;72:40-47. Epub 2019 Apr 5.

Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Staphylococcus aureus is a major causative microorganism in community- and healthcare-acquired pneumonia. CD5L is an important protein in the control of immune homeostasis. In this study, we found that patients with S. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.057DOI Listing
April 2019
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Natural chromones as potential anti-inflammatory agents: Pharmacological properties and related mechanisms.

Int Immunopharmacol 2019 Apr 5;72:31-39. Epub 2019 Apr 5.

Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, BA, Brazil; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, Brazil. Electronic address:

Chromones are a group of natural substances with a diversity of biological activities. Herein we assessed the pharmacological potential of three chromones (1, 2 and 3) isolated from Dictyoloma vandellianum as anti-inflammatory agents using in vitro and in vivo approaches. During in vitro screening, the production of NO and cytokines by macrophages stimulated with LPS and IFN-γ was inhibited by all chromones at concentrations (5-20 μM) that did not induce cytotoxicity. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.044DOI Listing
April 2019
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Genipin protects rats against lipopolysaccharide-induced acute lung injury by reinforcing autophagy.

Int Immunopharmacol 2019 Apr 5;72:21-30. Epub 2019 Apr 5.

Department of Critical Care Medicine, The First People's Hospital of Chenzhou/Institute of Translation Medicine, University of South China, Chenzhou 423000, China. Electronic address:

Although the protective effects of genipin against acute lung injury (ALI) have been described previously, the associated mechanism remains unclear. We have previously reported that genipin exerts its pharmacological effects by regulating autophagy. Here, we hypothesized that the up-regulation of autophagy may contribute to the protective effects exhibited by genipin against ALI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183143
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http://dx.doi.org/10.1016/j.intimp.2019.03.052DOI Listing
April 2019
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Influence of inflammasome pathway activation in macrophages on the matrix metalloproteinase expression of human hepatic stellate cells.

Int Immunopharmacol 2019 Apr 3;72:12-20. Epub 2019 Apr 3.

NuMeCan Institute (Nutrition, Metabolism and Cancer), Univ Rennes, INSERM, INRA, CHU Rennes, F-35000 Rennes, France.

Inflammasomes are protein complexes that produce IL-1β in response to damage or pathogens. As such, inflammasomes are involved in several types of hepatic fibrosis. However, the mechanisms by which these complexes drive the liver's fibrogenic status remain unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183135
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http://dx.doi.org/10.1016/j.intimp.2019.03.060DOI Listing
April 2019
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A novel concept of immunological and allergy interactions in autism spectrum disorders: Molecular, anti-inflammatory effect of osthole.

Int Immunopharmacol 2019 Apr 3;72:1-11. Epub 2019 Apr 3.

Department of Biology and Biotechnology, University of Warmia and Mazury, Oczapowskiego 1A Street, 10-719 Olsztyn, Poland.

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by Diagnosis and Statistic Manual 5 (DSM-5) as persistent social interaction and communication deficient across multiple contexts. Various immunological findings have been reported in children with ASD, and co-existing allergic problems have been recorded in children diagnosed with ASD. Osthole, the effective component of Chinese traditional medicine, is reported to have anti-inflammatory effects. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.058DOI Listing
April 2019
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Population pharmacokinetic modeling and simulation of immunoglobulin exposure with varying dosing intervals of subcutaneous immunoglobulin 20% (Ig20Gly) in patients with primary immunodeficiency diseases.

Int Immunopharmacol 2019 Apr 2;71:404-410. Epub 2019 Apr 2.

The Takeda group of companies, 650 E. Kendall St, Cambridge, MA, 02142, USA; University of California, Irvine, CA, USA. Electronic address:

Background: Immunoglobulin (IG) replacement therapy in patients with primary immunodeficiency diseases (PID) can be administered daily to every 2 weeks subcutaneously (SCIG) or every 3 or 4 weeks intravenously (IVIG).

Objectives: Develop a population pharmacokinetic (PK) model simulating IG exposure with Ig20Gly, a 20% SCIG; determine the dose adjustment factor for Ig20Gly relative to IVIG.

Methods: Data from patients with PID treated with Ig20Gly and IVIG 10% were used to characterize IG population PK by nonlinear mixed-effects modeling and validated using data splitting and a visual predictive check. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.034DOI Listing
April 2019
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Effects of different corticosteroid doses and durations on smoke inhalation-induced acute lung injury and pulmonary fibrosis in the rat.

Int Immunopharmacol 2019 Apr 2;71:392-403. Epub 2019 Apr 2.

Department of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital & Postgraduate Medical School, 100039 Beijing, China. Electronic address:

Excessive inflammation induced by cytokine storm and coagulation disorders is considered the primary characteristic of smoke inhalation-induced acute lung injury (SI-ALI). Glucocorticoids such as methylprednisolone (MP) are commonly used to treat patients with inflammatory diseases; however, the management of ALI or acute respiratory distress syndrome (ARDS) remains controversial. We explored the effects of different MP doses and durations in a rat SI-ALI model. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.051DOI Listing
April 2019
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2.472 Impact Factor

Anti-inflammatory mechanism of ginsenoside Rg1: Proteomic analysis of milk from goats with mastitis induced with lipopolysaccharide.

Int Immunopharmacol 2019 Apr 2;71:382-391. Epub 2019 Apr 2.

Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou 310058, PR China. Electronic address:

Previous investigation showed that intravenous injection of ginsenoside Rg1 had a therapeutic effect on Escherichia coli lipopolysaccharide-induced mastitis in lactating goats and it protected animals from lipopolysaccharide challenge via toll-like receptor 4 signaling pathway. The present study was to use proteomic approach to explore the anti-inflammatory mechanisms of Rg1. Nine dairy goats were randomly divided into three groups with 3 animals in each: groups 1 and 2 received intra-mammary infusion of lipopolysaccharide and then intravenously injected with saline or Rg1 solution; animals in group 3 were first intramammarily and then intravenously administered saline solution, and served as a control group. Read More

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The role of netrin-1 in the mouse cornea during Aspergillus fumigatus infection.

Int Immunopharmacol 2019 Apr 2;71:372-381. Epub 2019 Apr 2.

Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Purpose: To explore the effects of netrin-1 on inflammation in Aspergillus fumigatus-infected mouse corneas and on proliferation and migration in human corneal epithelial cells (HCECs).

Methods: Netrin-1 and the receptor A2BAR were detected in normal and infected corneas from C57BL/6 mice and RAW 264.7 cells. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.047DOI Listing
April 2019
2.472 Impact Factor

Trans sodium crocetinate alleviates ischemia/reperfusion-induced myocardial oxidative stress and apoptosis via the SIRT3/FOXO3a/SOD2 signaling pathway.

Int Immunopharmacol 2019 Apr 2;71:361-371. Epub 2019 Apr 2.

The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, PR China. Electronic address:

Trans sodium crocetinate (TSC) has been reported to exert a protective effect against cerebral ischemia/reperfusion (I/R) injury. However, whether TSC protects against myocardial ischemia/reperfusion (MI/R) injury remains unknown. Herein, we found that TSC treatment reduced myocardial infract size and elevated serum LDH and CK activities of MI/R rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183141
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http://dx.doi.org/10.1016/j.intimp.2019.03.056DOI Listing
April 2019
7 Reads
2.472 Impact Factor

CD30 ligand deficiency accelerates glioma progression by promoting the formation of tumor immune microenvironment.

Int Immunopharmacol 2019 Apr 2;71:350-360. Epub 2019 Apr 2.

Department of Immunology, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, PR China. Electronic address:

CD30 ligand (CD30L, CD153), belonging to the tumor necrosis factor superfamily, has been reported to act as an immune regulator mainly in several autoimmune diseases and Hodgkin's lymphoma. However, little is known about its regulation in the glioma microenvironment. In this study, using a GL261 mouse glioma model, we showed that CD30L deficiency in the host accelerated glioma growth and reduced mouse survival, which might be associated with the accumulation of tumor-infiltrating immune cells, especially tumor-associated macrophages, myeloid-derived suppressor cells and CD8 PD-1 T cells. Read More

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UCP2 ameliorates mitochondrial dysfunction, inflammation, and oxidative stress in lipopolysaccharide-induced acute kidney injury.

Int Immunopharmacol 2019 Apr 2;71:336-349. Epub 2019 Apr 2.

Department of Pediatrics, Zhujiang Hospital, Southern Medical University, 253 Gongye Road, Guangzhou 510280, Guangdong, China. Electronic address:

Objective: UCP2 is involved in the maintenance of mitochondrial function, immune response and regulation of oxidative stress under physiological or pathological conditions. The aim of this study was to investigate the effects of UCP2 on mitochondrial dysfunction, inflammation, and oxidative stress in septic acute kidney injury (AKI).

Methods: We established LPS-induced AKI model in mice and HK-2 cells. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.043DOI Listing
April 2019
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Protective effect of Ketone musk on LPS/ATP-induced pyroptosis in J774A.1 cells through suppressing NLRP3/GSDMD pathway.

Int Immunopharmacol 2019 Apr 2;71:328-335. Epub 2019 Apr 2.

Department of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, PR China; Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, PR China.

Pyroptosis is a different type of proinflammatory and lytic mode of cell death from apoptosis and necrosis, which play a killer and cleaner to the pathogenic microorganisms as an immune response when the host is infected by pathogenic microorganisms. Ketone musk (KM) is a component of the native musk, which is widely used to medicine and chemical engineering. In this research, we studied whether KM can suppress the pyroptosis in J774A. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.054DOI Listing
April 2019
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2.472 Impact Factor

Rhein protects against barrier disruption and inhibits inflammation in intestinal epithelial cells.

Int Immunopharmacol 2019 Apr 2;71:321-327. Epub 2019 Apr 2.

Division of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, China. Electronic address:

Background And Aims: Intestinal epithelial barrier and intestinal inflammation play indispensable roles in the development of intestinal diseases. The major aims of the current study were to investigate the potential of rhein, a major flavonoid compound isolated from Rheum rhabarbarum, in the treatment of intestinal diseases and its underlying mechanisms in vitro.

Methods: The protective role of rhein on intestinal epithelial barrier was evaluated in a monolayer of IEC-6 cells stimulated by TNF-α, while the anti-inflammatory effects were investigated in an IEC-6 cell model with LPS stimulation. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.030DOI Listing
April 2019
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The levels and significance of inflammasomes in the mouse retina following optic nerve crush.

Int Immunopharmacol 2019 Mar 30;71:313-320. Epub 2019 Mar 30.

Department of Ophthalmology, Daping Hospital and Institute of Surgery Research, Army Medical University, Chongqing, China. Electronic address:

Inflammasomes play an important role in neuroinflammation. However, their function during the secondary death of retinal cells after traumatic optic neuropathy and their dependence on pathogen stimuli remains unclear. Therefore, we evaluated the expression profiles of 10 different inflammasome-related mRNAs in the retina following an optic nerve crush (OPC) injury under both conventional sterile as well as non-sterile conditions, and validated two significantly varied ones on a protein level. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.029DOI Listing
March 2019
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Protective effects of ambroxol in psoriasis like skin inflammation: Exploration of possible mechanisms.

Int Immunopharmacol 2019 Mar 29;71:301-312. Epub 2019 Mar 29.

Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana 500037, India. Electronic address:

The purpose of this study was to investigate the protective effects of ambroxol in psoriasis-like skin inflammation both in vitro and in vivo and delineate the molecular mechanism of ambroxol. Our data demonstrated that ambroxol has an imperative role in inhibiting the lipopolysaccharide (LPS) stimulated nitrite levels, total cellular and mitochondrial reactive oxygen species level which was determined by Griess assay, DCFDA, and MitoSOX Red staining, respectively. We found that ambroxol remarkably reduced imiquimod (IMQ) induced epidermal hyperplasia, psoriasis area and severity index (PASI) scoring, splenomegaly, skin, and ear fold thickness. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.035DOI Listing
March 2019
2 Reads