5,365 results match your criteria International Immunopharmacology[Journal]


Hydrogen peroxide-inactivated bacteria induces potent humoral and cellular immune responses and releases nucleic acids.

Int Immunopharmacol 2019 Feb 16;69:389-397. Epub 2019 Feb 16.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, People's Republic of China. Electronic address:

The problem of nosocomial infection is seriously escalating. Bacterial vaccines are indispensable for preventing infections caused by multi-drug resistant organisms. Some researchers have put forward the use of hydrogen peroxide (HO) as a new technology platform for virus deactivation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.055DOI Listing
February 2019

Interleukin-33 prevents the development of autoimmune diabetes in NOD mice.

Int Immunopharmacol 2019 Feb 16;70:9-15. Epub 2019 Feb 16.

Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China; Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou 450052, Henan, China. Electronic address:

IL-33/ST2 signal is important for the generation of forkhead box P3 (Foxp3) regulatory (Treg) cells, which contribute to immune homeostasis in the context of diseases. The aim of this study was to determine whether targeting IL-33/ST2 signal could establish immunological tolerance and prevent type 1 diabetes (T1D) in nonobese diabetic (NOD) mice. Female NOD mice treated with IL-33 for 4 weeks decreased the incidence and delayed the onset of autoimmune diabetes, whereas IL-33 did not revert blood glucose concentration and disease development in mice with new-onset diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.02.018DOI Listing
February 2019

IL-21 reinvigorates exhausted natural killer cells in patients with HBV-associated hepatocellular carcinoma in STAT1-depedent pathway.

Int Immunopharmacol 2019 Feb 16;70:1-8. Epub 2019 Feb 16.

Department of Hepatobiliary Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China; The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China. Electronic address:

Hepatocellular carcinoma (HCC) is the most common liver malignancy with dismal prognosis and limited treatment options. Natural killer (NK) cells are critical components of antitumor immunity due to their capacity to eliminate MHC class I-deficient cells. To evaluate the function of NK cells in HCC patients, circulating CD3CD56 NK cells were collected from HBV-associated HCC patients and healthy control individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.02.007DOI Listing
February 2019

Oridonin inhibits IL-1β-induced inflammation in human osteoarthritis chondrocytes by activating PPAR-γ.

Int Immunopharmacol 2019 Feb 15;69:382-388. Epub 2019 Feb 15.

Department of Orthopaedic Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, Hei Longjiang Province 150086, China. Electronic address:

Osteoarthritis (OA), a progressive disease of the joints, affects millions of people worldwide. In the present study, we investigated the effects of oridonin, a diterpenoid isolated from Rabdosia rubescens, on IL-1β-induced inflammation using human osteoarthritis chondrocytes. The results showed that oridonin significantly suppressed IL-1β-induced MMP1, MMP3, and MMP13 production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.049DOI Listing
February 2019

Kaempferol protects chondrogenic ATDC5 cells against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-146a.

Int Immunopharmacol 2019 Feb 15;69:373-381. Epub 2019 Feb 15.

Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China. Electronic address:

Kaempferol is a kind of bioflavonoid exerts diverse pharmacological activities, including anti-apoptotic and anti-inflammatory activities. Kaempferol has been recognized as an effective agent for alleviating the clinical symptoms of osteoarthritis (OA). This study aimed to provide evidence that Kaempferol has potential in the management of OA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.02.014DOI Listing
February 2019

Novel aspects of the activation of NADPH oxidase in neutrophils of rheumatic patients on biological therapy.

Int Immunopharmacol 2019 Feb 15;69:368-372. Epub 2019 Feb 15.

5th Department of Internal Medicine, Medical Faculty of Comenius University, University Hospital, Ružinovská 6, 826 06 Bratislava, Slovak Republic.

The relationship between inflammation and formation of reactive oxygen species (ROS) is still not completely understood and excessive inflammatory reaction is attributed to increased yet also to reduced ROS formation. To compare ROS formation in severe and low inflammation, neutrophil oxidative burst was analyzed in rheumatic patients before and during therapy with TNFα- or interleukin-6 receptor-neutralizing antibodies. Intracellular and extracellular ROS productions were evaluated on the basis of luminol- and isoluminol-enhanced chemiluminescence in isolated peripheral neutrophils. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.02.015DOI Listing
February 2019

Cyclosporin A inhibits differentiation and activation of monocytic cells induced by 27-hydroxycholesterol.

Int Immunopharmacol 2019 Feb 15;69:358-367. Epub 2019 Feb 15.

Department of Pharmacology, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea. Electronic address:

27-Hydroxycholesterol (27OHChol) is a bioactive molecule that induces monocytic cell activation and differentiation and thereby participates in immune responses under hypercholesterolemic condition. However, it is unknown whether cyclosporin A (CsA), an immunosuppressant, affects biological effects of 27OHChol. In this study, we investigated whether CsA alters 27OHChol-induced cellular and molecular responses using the human monocyte/macrophage THP-1 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.045DOI Listing
February 2019

Changes among TGF-β1 Breg cells and helper T cell subsets in a murine model of allergic rhinitis with prolonged OVA challenge.

Int Immunopharmacol 2019 Feb 15;69:347-357. Epub 2019 Feb 15.

Department of Otolaryngology of Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning, China. Electronic address:

Background: Allergic rhinitis is a common allergic disease resulting from inappropriate Th2 cell-mediated immune responses to environmental antigens. As such, regulatory B cells and T helper cells play a critical role in the occurrence and development of allergic rhinitis.

Methods: Wild-type mice received ovalbumin (OVA) intranasal challenge for varied lengths of time, then the inflammatory state of their nasal mucosa was analyzed by histology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.009DOI Listing
February 2019

Anti-hyperalgesia effect of nanchelating based nano particle, RAc1, can be mediated via liver hepcidin expression modulation during persistent inflammation.

Int Immunopharmacol 2019 Feb 15;69:337-346. Epub 2019 Feb 15.

Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder accompanied with hyperalgesia, edema and pain. At least 30% of the patients failed to respond to the available treatments and medications, which yet have a lot of serious adverse effects on patients. So, using novel technologies to produce more efficient medications is needed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.02.003DOI Listing
February 2019

Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytes.

Int Immunopharmacol 2019 Feb 14;69:328-336. Epub 2019 Feb 14.

Faculty of Medicine, University of Iceland, Biomedical Center, Vatnsmyrarvegur 16, IS-101 Reykjavik, Iceland; Department of Immunology, Landspitali-The National University Hospital of Iceland, Bld 14 at Eiriksgata, IS-101 Reykjavik, Iceland; Center for Rheumatology Research, Landspitali-The National University Hospital of Iceland, Bld 14 at Eiriksgata, IS-101 Reykjavik, Iceland. Electronic address:

Regular bathing in the Blue Lagoon has beneficial effects on psoriasis. Previously, we showed that exopolysaccharides (EPS-Ca) secreted by Cyanobacterium aponinum, a dominating organism in the Blue Lagoon, increased IL-10 secretion by human dendritic cells (DCs). In addition, co-culturing allogeneic CD4 T cells with DCs matured in the presence of EPS-Ca increased differentiation of T cells into T regulatory cells at the cost of the disease inducing Th17 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.044DOI Listing
February 2019

Host's immune response in unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis treated by meglumine antimoniate: A case-control study of Th1 and Th2 pathways.

Int Immunopharmacol 2019 Feb 13;69:321-327. Epub 2019 Feb 13.

Dadbin Health Clinic, Kerman University of Medical Sciences, Kerman, Iran.

The objective of the present study was to compare the host's immune responses between unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis (ACL) treated by meglumine antimoniate. A case-control study was carried out in an endemic focus in Iran. Blood samples were taken from patients and peripheral blood mononuclear cells (PBMCs) were isolated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.02.008DOI Listing
February 2019

Long non-coding RNA activated by transforming growth factor beta alleviates lipopolysaccharide-induced inflammatory injury via regulating microRNA-223 in ATDC5 cells.

Int Immunopharmacol 2019 Feb 13;69:313-320. Epub 2019 Feb 13.

Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China. Electronic address:

Osteoarthritis (OA) is a conversant joint disease, which seriously threatens the health of the elderly, and even leads to disability. Long non-coding RNA-activated by transforming growth factor beta (lncRNA-ATB) has been reported in diverse cancers. However, the functions of lncRNA-ATB in OA remain uninvestigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.056DOI Listing
February 2019

Tetrandrine inhibits differentiation of proinflammatory subsets of T helper cells but spares de novo differentiation of iTreg cells.

Int Immunopharmacol 2019 Feb 12;69:307-312. Epub 2019 Feb 12.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macau SAR, China. Electronic address:

Tetrandrine (TET) is an anti-inflammatory compound isolated from Chinese herb Stephania tetrandra S. Moore. It was reported recently that the differentiation of Th17 cells was inhibited, while the generation of induced Treg cells (iTregs) was promoted, by TET treatment. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15675769183115
Publisher Site
http://dx.doi.org/10.1016/j.intimp.2019.01.040DOI Listing
February 2019
1 Read

Corrigendum to "Tryptase inhibitor APC 366 prevents hepatic fibrosis by inhibiting collagen synthesis induced by tryptase/protease-activated receptor 2 interactions in hepatic stellate cells" [Int. Immunopharmacol. 20 (2014) 352-357].

Int Immunopharmacol 2019 Feb 9. Epub 2019 Feb 9.

Department of Laboratory Animal Science, School of Basic Medical Science, Capital Medical University, Beijing 100069, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.034DOI Listing
February 2019

Down-regulated Treg cells in exacerbated periodontal disease during pregnancy.

Int Immunopharmacol 2019 Feb 9;69:299-306. Epub 2019 Feb 9.

Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202, USA. Electronic address:

Pregnancy is a special period marked with complicated changes in various immune responses. Although pregnant women are prone to developing gingival inflammation, its immunological mechanism remains to be clarified. In a modified ligature-induced periodontal disease murine model, pregnant mice developed more severe alveolar bone loss. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.031DOI Listing
February 2019

BML-111 accelerates the resolution of inflammation by modulating the Nrf2/HO-1 and NF-κB pathways in rats with ventilator-induced lung injury.

Int Immunopharmacol 2019 Feb 8;69:289-298. Epub 2019 Feb 8.

Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

The timely resolution of pulmonary inflammation coordinated by endogenous pro-resolving mediators helps limit lung tissue injury, but few endogenous pro-resolving mediators that are normally operative during acute inflammation. The protective effects of BML-111 (5(S)-6(R)-7-trihydroxyheptanoic acid methyl ester), a potent commercially available anti-inflammatory and pro-resolving mediator, on ventilation-induced lung injury (VILI) have been extensively studied, but its characteristics as a pro-resolving mediator have not. Here, anesthetized Sprague-Dawley rats were ventilated with a high tidal volume (20 mL/kg, HV) for 1 h and randomly allocated to recover for 6, 12, 24, 48, 72, 96 or 168 h; BML-111 was administered at the peak of inflammation to evaluate its pro-resolving effect on VILI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.02.005DOI Listing
February 2019
2 Reads

Prevention and treatment of cervical cancer by a single administration of human papillomavirus peptide vaccine with CpG oligodeoxynucleotides as an adjuvant in vivo.

Int Immunopharmacol 2019 Feb 8;69:279-288. Epub 2019 Feb 8.

Department of Microbiology and Parasitology, College of Basic Medical Sciences, China Medical University, Shenyang, China. Electronic address:

No licensed therapeutic human papillomavirus (HPV) vaccine is currently available, so it remains a high priority to develop a therapeutic HPV vaccine or prophylactic/therapeutic HPV vaccine for cervical cancer. In this current study, we designed an HPV vaccine including CpG oligodeoxynucleotides 1826 as an adjuvant and HPV16 E7 43-77 peptide as antigen, which contains a CD8 T cell epitope (E7 49-57), and two CD4 T cell epitopes (E7 43-77 and E7 50-62). The prophylactic and therapeutic effect on cervical cancer induced by a single administration of vaccine, were comprehensively evaluated by examining the tumor size and the percentage of tumor-free/bearing mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.024DOI Listing
February 2019
1 Read

Genistein suppresses psoriasis-related inflammation through a STAT3-NF-κB-dependent mechanism in keratinocytes.

Int Immunopharmacol 2019 Feb 8;69:270-278. Epub 2019 Feb 8.

Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, Guangdong, China; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510120, Guangdong, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou 510120, Guangdong, China. Electronic address:

Psoriasis is a chronic recurrent skin inflammatory disease, and inhibition of inflammation may be an effective means of treating psoriasis. The flavonoid genistein has a clear anti-inflammatory effect. However, the anti-psoriatic effects of genistein and their underlying mechanisms remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.054DOI Listing
February 2019
1 Read

Microbiosis in pathogenesis and intervention of atopic dermatitis.

Int Immunopharmacol 2019 Feb 8;69:263-269. Epub 2019 Feb 8.

Department of Dermatology, Third Xiangya Hospital of Central South University, Changsha, Hunan 41006, China. Electronic address:

Atopic dermatitis (AD) is a chronic, non-contagious, inflammatory skin disorder characterized by relapsing eczematous lesions. Its pathogenesis remains incompletely understood. The current evidence has emerged to show that skin and gut microbiome play critical roles in the pathogenesis and progression of AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.030DOI Listing
February 2019

Association between the ratio of aryl hydrocarbon receptor (AhR) in Th17 cells to AhR in Treg cells and SLE skin lesions.

Int Immunopharmacol 2019 Feb 8;69:257-262. Epub 2019 Feb 8.

Gansu Key Laboratory of Functional Genomics and Molecular Diagnosis, East Road no. 110 Nanhe Yantan, Chengguan District, Lanzhou, Gansu Province, PR China; Laboratory of Precision Medicine and Translational Medicine, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou Science and Technology Town Hospital, Suzhou, Jiangsu Province, PR China.

Skin lesions are typical clinical manifestations of systemic lupus erythematosus (SLE) and the biomarker for predicting SLE skin injury is not clear. We conducted a hospital-based case-control study with aim to explore the predictive value of the ratio of aryl hydrocarbon receptor (AhR) in T helper 17 (Th17) cells to AhR in regulatory T (Treg) cells (AhR ratio) in SLE skin lesions. The clinical and laboratory data were obtained from their medical records, and the AhR relative expression levels were evaluated by reverse transcription-quantitative polymerase chain reaction. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15675769183111
Publisher Site
http://dx.doi.org/10.1016/j.intimp.2019.01.039DOI Listing
February 2019
2 Reads
2.472 Impact Factor

Protective effects of berberine hydrochloride on DSS-induced ulcerative colitis in rats.

Int Immunopharmacol 2019 Mar 8;68:242-251. Epub 2019 Feb 8.

Department of Gastroenterology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine (Jiang Su Province Hospital of TCM), Nan Jing, 210029, Jiang Su Province, China. Electronic address:

Background: Berberine hydrochloride is one the effective compound among Rhizoma Coptidis, Cortex Phellodendri, and other plants. There are several clinical functions of berberine hydrochloride including anti-inflammation, antitumor and immunoregulatory. However, the anti-inflammatory of berberine hydrochloride in ulcerative colitis is barely understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2018.12.036DOI Listing
March 2019
1 Read

PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism.

Int Immunopharmacol 2019 Feb 7;69:245-256. Epub 2019 Feb 7.

Department of Psychiatry, Maastricht University, Holland, the Netherlands.

The transcription factor, PPARδ is involved in suppressing inflammation, stimulating oligodendroglial biogenesis and myelination. Furthermore, activation of PPARδ directly protects mitochondria against noxious stimuli and stimulates biogenesis of new mitochondria. PPARδ activation directly inhibits neuronal cell death and reduces both the level and neurotoxicity of Amyloid-β fibers in Alzheimer's Disease (AD) models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.057DOI Listing
February 2019
1 Read

Oral cholecalciferol supplementation alleviates lipopolysaccharide-induced preterm delivery partially through regulating placental steroid hormones and prostaglandins in mice.

Int Immunopharmacol 2019 Feb 7;69:235-244. Epub 2019 Feb 7.

Department of Toxicology, Anhui Medical University, Hefei 230032, China; Key Laboratory of Environmental Toxicology, Anhui Higher Education Institutes, Anhui Medical University, Hefei 230032, China; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei 230032, China. Electronic address:

Several epidemiological reports demonstrated that vitamin D deficiency elevated risk of preterm delivery. We investigate the effects of oral cholecalciferol (VD3) supplementation on lipopolysaccharide (LPS)-induced preterm delivery. Pregnant mice were randomly assigned to either oral VD3 (25 μg/kg) or corn oil once daily from gestational day (GD)13 to GD15, and were intraperitoneally injected with either LPS (200 μg/kg) or normal saline on GD15. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.052DOI Listing
February 2019

Heme oxygenase-1 induced by desoxo-narchinol-A attenuated the severity of acute pancreatitis via blockade of neutrophil infiltration.

Int Immunopharmacol 2019 Feb 7;69:225-234. Epub 2019 Feb 7.

Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 54538, South Korea; Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, Iksan, Jeonbuk 54538, South Korea. Electronic address:

Heme oxygenase-1 (HO-1) has an anti-inflammatory action in acute pancreatitis (AP). However, its mechanism of action and natural compounds/drugs to induce HO-1 in pancreas are not well understood. In this study, we investigated the regulatory mechanisms of HO-1 during AP using desoxo-narchinol-A (DN), the natural compound inducing HO-1 in the pancreas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.051DOI Listing
February 2019
1 Read

Generation and characterization of a specific single-chain antibody against DSPP as a prostate cancer biomarker: Involvement of bioinformatics-based design of novel epitopes.

Int Immunopharmacol 2019 Feb 6;69:217-224. Epub 2019 Feb 6.

Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Isolation of specific single chain antibodies (scFvs) against key epitopes of cancer markers are applied for cancer immunotherapy and diagnosis. In this study following the prediction of the 3D structure of the DSP part of Dentin sialophosphoprotein (DSPP), the epitope was chosen using in silico programs. Panning process was applied to isolate specific human scFv against the epitope. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.016DOI Listing
February 2019
1 Read

Curcumin attenuates murine lupus via inhibiting NLRP3 inflammasome.

Int Immunopharmacol 2019 Feb 6;69:213-216. Epub 2019 Feb 6.

Department of Nephrology, Fourth Affiliated Hospital of Guangxi Medical University, Guangxi 545005, China. Electronic address:

Despite rapid progress in the understanding of systemic lupus erythematosus (SLE), there is still an urgent need for novel and more effective interventions. Curcumin, a natural polyphenol compound, has been shown to be anti-inflammatory in various disorders. In this study, we investigated the potential therapeutic value of curcumin in SLE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.046DOI Listing
February 2019
4 Reads

Morphological and functional analysis of beige (Chèdiak-Higashi syndrome) mouse mast cells with giant granules.

Int Immunopharmacol 2019 Feb 6;69:202-212. Epub 2019 Feb 6.

Department of Pharmacology, Ehime University Graduate School of Medicine Shitsukawa, Toon, Ehime 791-0295, Japan.

Chèdiak-Higashi syndrome is a rare autosomal recessive disease that causes hypopigmentation, recurrent infections, mild coagulation defects and neurological problems. Beige mice carry a mutation in the lysosome trafficking regulator (LYST) gene and display some of the key characteristics of human Chèdiak-Higashi syndrome, in particular, a high susceptibility to infection due to aberrant natural killer (NK) cell and polymorphonuclear leucocyte function. Morphological analysis of beige mice reveals the presence of enlarged lysosomes in a variety of cell types, including leucocytes, hepatocytes, fibroblasts and renal tubule cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.053DOI Listing
February 2019
1 Read

Different phenotypes of CD4CD25Foxp3 regulatory T cells in recipients post liver transplantation.

Int Immunopharmacol 2019 Feb 5;69:194-201. Epub 2019 Feb 5.

Department of Transplant Surgery, Tianjin First Center Hospital, Tianjin 300192, China; Key Laboratory of Organ Transplantation of Tianjin, Tianjin 300192, China; Tianjin Clinical Research Center for Organ Transplantation, Tianjin 300192, China. Electronic address:

CD4 regulatory T cells (Tregs) play an important role in inducing immune tolerance in organ transplantation, which can be divided into CD45RATregs (resting Tregs, rTregs) and CD45ROTregs (activated Tregs, aTregs). Currently, the expressions and phenotypic changes of Tregs in recipients after liver transplantation (LT) is unknown. We therefore investigated the expression and transformation of rTregs and aTregs in 83 cases of recipients with normal status post-LT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.048DOI Listing
February 2019
1 Read

IL-37 suppresses the sustained hepatic IFN-γ/TNF-α production and T cell-dependent liver injury.

Int Immunopharmacol 2019 Feb 5;69:184-193. Epub 2019 Feb 5.

Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, People's Republic of China. Electronic address:

T cell-dependent liver injury is an important reason for the massive hepatic damage and cirrhosis. So far it is unclear whether the development of the disease could be efficiently suppressed by anti-inflammatory cytokine that modulates innate immune cells. Here we report that anti-inflammatory cytokine IL-37 could efficiently suppress the sustained hepatic expression of IFN-γ and TNF-α, two critical cytokines for inducing hepatocyte apoptosis and liver fibrosis in T cell-dependent liver injury. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15675769193019
Publisher Site
http://dx.doi.org/10.1016/j.intimp.2019.01.037DOI Listing
February 2019
2 Reads

Glucose-6-phosphate dehydrogenase (G6PD) activity can modulate macrophage response to Leishmania major infection.

Int Immunopharmacol 2019 Feb 1;69:178-183. Epub 2019 Feb 1.

Department of Clinical Biochemistry, Faculty of Medical Sciences Tarbiat Modares University, Tehran, Iran.

Glucose-6-phosphate dehydrogenase (G6PDH) ultimately plays a critical role in macrophage functions used against infectious agents. The present study investigated whether changes in G6PDH activity could influence the resistance of infected macrophages against Leishmania major infection. Mouse peritoneal and J774 macrophages were infected, respectively, ex vivo and in vitro, with L. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15675769183106
Publisher Site
http://dx.doi.org/10.1016/j.intimp.2019.01.028DOI Listing
February 2019
5 Reads

Fraxinellone inhibits inflammatory cell infiltration during acute pancreatitis by suppressing inflammasome activation.

Int Immunopharmacol 2019 Feb 1;69:169-177. Epub 2019 Feb 1.

Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 540-749, South Korea; Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, Iksan, Jeonbuk 54538, South Korea. Electronic address:

Inflammasomes promote the production of pro-inflammatory cytokines, such as interleukin (IL)-1β and IL-18, which are the representative mediators of inflammation. Abnormal activation of inflammasomes leads to the development of inflammatory diseases such as acute pancreatitis (AP). In this study, we demonstrate the inhibitory effects of a new natural compound fraxinellone on inflammasome formation and examine the role of inflammasomes in a mouse model of AP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.043DOI Listing
February 2019
1 Read

Exacerbating effects of trimellitic anhydride in ovalbumin-induced asthmatic mice and the gene and protein expressions of TRPA1, TRPV1, TRPV2 in lung tissue.

Int Immunopharmacol 2019 Feb 1;69:159-168. Epub 2019 Feb 1.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.

With the increasing morbidity and mortality of asthma, asthma aggravated by environmental pollution has drawn more attention. This study investigated the exacerbating effects of trimellitic anhydride (TMA), a typical pollutant, in ovalbumin (OVA)-induced asthmatic mice and the gene and protein expressions of TRPA1, V1, V2 in lung tissue. Female BALB/c mice were respectively administered for 42 days as follow: sensitized and challenged with OVA, sensitized and challenged with TMA, sensitized with OVA and challenged with OVA plus TMA, as well as sensitized and challenged with OVA plus TMA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.038DOI Listing
February 2019
3 Reads

The change of immunosuppressive regimen from calcineurin inhibitors to mammalian target of rapamycin (mTOR) inhibitors and its effect on malignancy following heart transplantation.

Int Immunopharmacol 2019 Jan 30;69:150-158. Epub 2019 Jan 30.

Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Malignancy is a significant cause of mortality after organ transplantation. There is an increased rate of malignancy following heart transplantation (HTx) compared to the general population and other organ transplant recipients. Post-HTx patients with a history of malignancy are also at a higher risk of developing new malignancies or exacerbation of their existing malignancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.035DOI Listing
January 2019
1 Read

LPS induces CXCL16 expression in HUVECs through the miR-146a-mediated TLR4 pathway.

Int Immunopharmacol 2019 Jan 30;69:143-149. Epub 2019 Jan 30.

Department of Neurology, The Affiliated Hospital of the Qingdao University, Medical School of Qingdao University, Qingdao, Shandong Province 266100, China. Electronic address:

Endothelial inflammation characterizes the early stages of atherosclerosis. CXCL16 is a protein that functions as both a chemokine and adhesion molecule, playing a crucial role in the pathogenesis of atherosclerosis. However, it is uncertain if LPS, a major inducer of inflammation, affects CXCL16 expression in endothelial cells and whether miR-146a, a negative regulator of atherosclerosis, participates in this process. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15675769183094
Publisher Site
http://dx.doi.org/10.1016/j.intimp.2019.01.011DOI Listing
January 2019
2 Reads

IL-21-mediated expansion of Vγ9Vδ2 T cells is limited by the Tim-3 pathway.

Int Immunopharmacol 2019 Jan 29;69:136-142. Epub 2019 Jan 29.

Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen 361003, P.R. China. Electronic address:

Vγ9Vδ2 T cells are the main γδ T subset in the peripheral blood and lymphoid organs. Previous studies have shown that Vγ9Vδ2 T cells could expand in the presence of phosphoantigens and IL-2 and exert antitumor functions. However, their potency was limited because sustained proliferation could not be achieved, possibly due to exhaustion caused by prolonged antigenic stimulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.027DOI Listing
January 2019
1 Read

Mmu-miR-92a-2-5p targets TLR2 to relieve Schistosoma japonicum-induced liver fibrosis.

Int Immunopharmacol 2019 Jan 29;69:126-135. Epub 2019 Jan 29.

School of Nursing, Guilin Medical University, Guilin 541001, Guangxi, China. Electronic address:

According to conservative estimates, >230 million people are infected with schistosomiasis,which becomes one of the most common parasitic diseases. This study focuses on investigating in vivo and in vitro effects of mmu-miR-92a-2-5p in Schistosoma japonicum-induced liver fibrosis by targeting TLR2. Through bioinformatic analysis, the overexpression of TLR2 and the down-regulation of mmu-miR-92a-2-5p were revealed in the progression of S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.007DOI Listing
January 2019

Phenobarbital inhibits osteoclast differentiation and function through NF-κB and MAPKs signaling pathway.

Int Immunopharmacol 2019 Jan 28;69:118-125. Epub 2019 Jan 28.

School of Public Health, Shandong University, Jinan, China. Electronic address:

The purpose of this study was to determine the direct effects of phenobarbital (PB) on receptor activator of nuclear factor kappa-B ligand (RANKL) induced osteoclast differentiation and function in vitro and in vivo. Here, PB significantly inhibited osteoclast formation and bone resorption ability induced by RANKL in vitro. Meanwhile, intracellular signaling transduction analysis revealed PB specifically decreasing the phosphorylation level of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK), respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.033DOI Listing
January 2019
1 Read
2.472 Impact Factor

Acteoside ameliorates inflammatory responses through NFkB pathway in alcohol induced hepatic damage.

Int Immunopharmacol 2019 Jan 28;69:109-117. Epub 2019 Jan 28.

Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, India. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15675769183062
Publisher Site
http://dx.doi.org/10.1016/j.intimp.2019.01.020DOI Listing
January 2019
3 Reads
2.472 Impact Factor

Inhibition of GSK-3β alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy.

Int Immunopharmacol 2019 Mar 28;68:234-241. Epub 2019 Jan 28.

Department of Pathophysiology, Chongqing Medical University, Chongqing, PR China; Institute of Neuroscience, Chongqing Medical University, Chongqing, PR China. Electronic address:

The nod-like receptor protein 3 (NLRP3) inflammasome has a critical role in cerebral ischemic injury, and autophagy is related to activation of the inflammasome under oxidative stress conditions. However, it is unclear how NLRP3 inflammasome activation is regulated. Glycogen synthase kinase 3β (GSK-3β) emerged as an important risk factor for brain ischemia reperfusion injury, and GSK-3β inhibits autophagic activity in many diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2018.12.042DOI Listing
March 2019
1 Read

Exogenous ghrelin ameliorates acute lung injury by modulating the nuclear factor κB inhibitor kinase/nuclear factor κB inhibitor/nuclear factor κB pathway after hemorrhagic shock.

Int Immunopharmacol 2019 Jan 24;69:95-102. Epub 2019 Jan 24.

Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin 150001, China. Electronic address:

Previous studies have shown that ghrelin, a peptide produced in the stomach, attenuates acute lung injury (ALI) in various animal models, and that some of these effects are associated with inhibition of the nuclear factor κB signaling pathway. This study investigated whether ghrelin exerts beneficial effects on hemorrhagic shock (HS)-induced ALI by modulating nuclear factor κB inhibitor kinase/nuclear factor κB inhibitor/nuclear factor κB (IKK/IκBα/NF-κB) pathway activity. HS was induced in male SD rats by withdrawing blood to a mean arterial pressure (MAP) of 40 mm Hg for 1 h; rats then received ghrelin (10 nmol/kg) or vehicle intravenously and were resuscitated with the shed blood and an equal volume of Ringer lactate solution followed by observation for 2 h. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.019DOI Listing
January 2019

Maresin1 regulates neutrophil recruitment and IL-10 expression in Aspergillus fumigatus keratitis.

Int Immunopharmacol 2019 Jan 25;69:103-108. Epub 2019 Jan 25.

Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China. Electronic address:

Purpose: Maresin1, a lipid mediator derived from polyunsaturated fatty acids, has been shown to suppress the inflammatory response in various inflammatory diseases. However, its effects in fungal keratitis are still uncertain. In this study, we investigated the role of maresin1 (MaR1) in Aspergillus fumigatus keratitis of the eye in a mouse model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.032DOI Listing
January 2019

Semaphorin 4A acts in a feed-forward loop with NF-κB pathway to exacerbate catabolic effect of IL-1β on chondrocytes.

Int Immunopharmacol 2019 Jan 24;69:88-94. Epub 2019 Jan 24.

The Fourth Department of Orthopedics, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, China.

Inflammation is fundamental in osteoarthritis (OA) pathogenesis. Semaphorin 4A (Sema4A) has been implicated in immune-associated diseases, however, its role in OA remains unclear. In this study, we show that Sema4A is upregulated in knee OA articular cartilage as well as in chondrocytes exposed to IL-1β treatment in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.006DOI Listing
January 2019
2.472 Impact Factor

Peroxiredoxin 6 knockout aggravates cecal ligation and puncture-induced acute lung injury.

Int Immunopharmacol 2019 Mar 22;68:252-258. Epub 2019 Jan 22.

Department of Pulmonary Medicine, Zhongshan Hospital of Fudan University, Shanghai, PR China.

Background: The aim of present study was to investigate the effects and mechanisms of peroxiredoxin (Prdx) 6 on cecal ligation and puncture (CLP) induced acute lung injury (ALI) in mice.

Methods: The cecal of male Prdx 6 knockout and wildtype C57BL/6J mice were ligated and perforated. Stool was extruded to ensure wound patency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2018.12.053DOI Listing
March 2019
1 Read

Preventive effect of Diallyl Trisulfide on cutaneous toxicities induced by EGFR inhibitor.

Int Immunopharmacol 2019 Jan 22;69:79-87. Epub 2019 Jan 22.

Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China; Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China. Electronic address:

Cutaneous toxicities are the commonest side effects in patients with cancer treated using epidermal growth factor receptor inhibitors such as erlotinib. For patients with such toxicities, there is a lack of safe, effective pharmacological agents. Here we established a skin toxicity model and investigated the preventive and therapeutic effect of Diallyl Trisulfide (DATS) in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.023DOI Listing
January 2019

Quercetin reduces Streptococcus suis virulence by inhibiting suilysin activity and inflammation.

Int Immunopharmacol 2019 Jan 22;69:71-78. Epub 2019 Jan 22.

Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China. Electronic address:

Streptococcus suis, a globally distributed bacterial pathogen, is an important zoonotic agent for humans and animals that can lead to multiple deaths and cause major economic losses. Suilysin (SLY), secreted by most pathogenic S. suis strains, is a cytotoxic toxin that belongs to the cholesterol-dependent cytolysin family; this toxin plays a key role in a mouse meningitis model, suggesting that effective interference with the biological activity of SLY may be a potential treatment for S. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15675769183088
Publisher Site
http://dx.doi.org/10.1016/j.intimp.2019.01.017DOI Listing
January 2019
3 Reads

NADPH oxidase 2-mediated NLRP1 inflammasome activation involves in neuronal senescence in hippocampal neurons in vitro.

Int Immunopharmacol 2019 Jan 21;69:60-70. Epub 2019 Jan 21.

Department of Pharmacology, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, PR China. Electronic address:

Oxidative stress and inflammation are closely related to neuron ageing. NADPH oxidase 2 (NOX2) is a major source of reactive oxygen species (ROS) generation in brain. The nucleotide-binding oligomerisation domain (NOD)-like receptor protein 1 (NLRP1) inflammasome is responsible for the formation of proinflammatory molecules in neurons. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.025DOI Listing
January 2019
2.472 Impact Factor

Dual effect of T helper cell 17 (Th17) and regulatory T cell (Treg) in liver pathological process: From occurrence to end stage of disease.

Int Immunopharmacol 2019 Jan 19;69:50-59. Epub 2019 Jan 19.

Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China; Center for Drug Screening and Pharmacodynamics Evaluation, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address:

Liver disease is a complicated pathological status with acute or chronic progressions, causing a series of damages to liver and massive burden to public health and society. Th17 and Treg, two subsets of CD4 T helper cells, seem to keep a subtle balance in the maintenance of organic immune homeostasis including liver. The dysfunction of Th17/Treg balance in liver has been proved associated with hepatic injury and disease. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15675769183098
Publisher Site
http://dx.doi.org/10.1016/j.intimp.2019.01.005DOI Listing
January 2019
3 Reads

Rohitukine inhibits NF-κB activation induced by LPS and other inflammatory agents.

Int Immunopharmacol 2019 Jan 18;69:34-49. Epub 2019 Jan 18.

Academy of Scientific & Innovative Research (AcSIR), New Delhi, India; PK-PD-Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J & K, India. Electronic address:

Rohitukine (referred to as RHK) is a bioactive chromone alkaloid isolated from the leaves of plant Dysoxylum binectariferum, which has been reported to possess diverse pharmacological properties for the treatment of inflammatory bowel disease (IBD), diarrhoea and anti-lipidemic. However, the underlying mechanism by which RHK exerts its anti-inflammatory activity has not yet demonstrated. This study aimed to elucidate the anti-inflammatory mechanism of RHK using lipopolysaccharide (LPS) - stimulated J774A. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15675769193006
Publisher Site
http://dx.doi.org/10.1016/j.intimp.2019.01.015DOI Listing
January 2019
7 Reads
2.472 Impact Factor

IL-37 attenuates allergic process via STAT6/STAT3 pathways in murine allergic rhinitis.

Int Immunopharmacol 2019 Jan 18;69:27-33. Epub 2019 Jan 18.

Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China. Electronic address:

Allergic rhinitis (AR) is a common upper airway allergic disease caused by allergens triggering a type 2 immune response. The imbalance of CD4+ T cell subsets is the essential immunological feature of AR, which is mainly characterized by the predominance of T helper (Th) 2 cells. Recent studies indicated that the anti-inflammatory factor interleukin (IL)-37 is involved in the immune regulation of AR. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15675769183121
Publisher Site
http://dx.doi.org/10.1016/j.intimp.2019.01.013DOI Listing
January 2019
5 Reads

S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: Involvement of oxidative stress and inflammation.

Int Immunopharmacol 2019 Jan 18;69:19-26. Epub 2019 Jan 18.

Neurophysiology Research Center, Department of Physiology, Shahed University, Tehran, Iran. Electronic address:

Sepsis is a serious and life-threatening medical condition with a higher rate of patients' morbidity and mortality and with complications such as acute kidney injury (AKI). S-allyl cysteine (SAC) is the active constituent of the medicinal plant garlic (Allium sativum) with multiple beneficial effects including anti-inflammatory and antioxidant properties. In this research, we tried to determine the protective effect of SAC pretreatment in a mouse model of AKI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.026DOI Listing
January 2019
3 Reads