4,462 results match your criteria International Archives of Allergy and Immunology[Journal]


TNF-TNFR2 Signaling Inhibits Th2 and Th17 Polarization and Alleviates Allergic Airway Inflammation.

Int Arch Allergy Immunol 2019 Feb 14:1-10. Epub 2019 Feb 14.

Department of Respiratory Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: TNF-TNFR2 signaling has been indicated to be involved in CD4+ T lymphocyte differentiation. However, its role in allergic airway inflammation is not well understood.

Objectives: The aim of this study was to investigate the role of TNF-TNFR2 signaling in allergic airway inflammation. Read More

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http://dx.doi.org/10.1159/000493583DOI Listing
February 2019

Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis.

Int Arch Allergy Immunol 2019 Feb 14:1-6. Epub 2019 Feb 14.

Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Republic of

Background: We conducted a meta-analysis to determine a practical observation time for detecting a biphasic reaction after resolution of the initial anaphylactic reaction.

Methods: A systematic literature search identified studies on adult patients with anaphylaxis and a subsequent biphasic reaction due to various causes that contained sufficient data to extract outcomes. The outcomes were pooled using a random-effects model. Read More

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http://dx.doi.org/10.1159/000496092DOI Listing
February 2019

Patterns in Google Trends Terms Reporting Rhinitis and Ragweed Pollen Season in Ukraine.

Int Arch Allergy Immunol 2019 Feb 13:1-7. Epub 2019 Feb 13.

University Hospital, Montpellier, France.

Background: Google Trends (GT) may represent a new approach to assessing pollen allergy. However, the development of a pan-European sentinel network has raised a problem of translating terms in different languages. A precise definition of the pollen season onset is crucial for the confirmation of a pollen allergy diagnosis and personalized treatment. Read More

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http://dx.doi.org/10.1159/000495306DOI Listing
February 2019

Beneficial Effect of Early Intervention with Garenoxacin for Bacterial Infection-Induced Acute Exacerbation of Bronchial Asthma and Chronic Obstructive Pulmonary Disease.

Int Arch Allergy Immunol 2019 Feb 13:1-8. Epub 2019 Feb 13.

Division of Allergology and Respiratory Medicine, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

Background: Chronic obstructive pulmonary disease (COPD) and asthma have similar clinical features and are both exacerbated by airway infection.

Objective: To determine whether garenoxacin mesylate hydrate (GRNX) added to the standard care for bacterial infection-induced acute exacerbation of asthma or COPD in adults has clinical benefits.

Method: This single-arm clinical trial was conducted from January 2015 to March 2016. Read More

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http://dx.doi.org/10.1159/000495761DOI Listing
February 2019

Preclinical Brown Norway Rat Models for the Assessment of Infant Formulas in the Prevention and Treatment of Cow's Milk Allergy.

Int Arch Allergy Immunol 2019 Feb 13:1-8. Epub 2019 Feb 13.

National Food Institute, Technical University of Denmark, Kgs. Lyngby,

Background: Infant formulas (IFs) based on hydrolysed cow's milk proteins are central in the management of cow's milk allergy (CMA) in infants and small children. New IF compositions with improved prevention and treatment properties are needed, along with appropriate preclinical animal models, to evaluate these properties before introduction into humans.

Objectives: We aimed to develop preclinical models for the assessment of the primary preventive and desensitising capacity of cow's milk IF in allergy-prone, high-IgE responder Brown Norway rats. Read More

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http://dx.doi.org/10.1159/000495801DOI Listing
February 2019

Early Introduction of Egg and Development of Egg Allergy.

Int Arch Allergy Immunol 2019 Feb 8:1-2. Epub 2019 Feb 8.

Department of Immunology, Landspitali University Hospital, Reykjavik, Iceland.

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http://dx.doi.org/10.1159/000496266DOI Listing
February 2019

Atopic Dermatitis: Collegium Internationale Allergologicum (CIA) Update 2019.

Int Arch Allergy Immunol 2019 Feb 8:1-12. Epub 2019 Feb 8.

Institute of Pharmacology, University of Bern, Bern, Switzerland.

Atopic dermatitis (AD) is a chronic inflammatory skin disease presenting with recurrent eczematous lesions and intense pruritus. It is common and affects both children and adults, often beginning in infancy. Due to the unpredictable disease course, its visible skin lesions, itching and scratching followed by sleeplessness, other associated atopic diseases, and behavioral and psychiatric disorders, AD is an immense burden for patients and caregivers. Read More

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https://www.karger.com/Article/FullText/497383
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February 2019
1 Read

Early Introduction of Egg and Development of Egg Allergy.

Int Arch Allergy Immunol 2019 Feb 8:1-2. Epub 2019 Feb 8.

Health Services Research and International Health, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.

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http://dx.doi.org/10.1159/000495578DOI Listing
February 2019

Transient Receptor Potential Ankyrin 1 Enhances Ovalbumin-Induced Acute Allergic Inflammation in Murine Models.

Int Arch Allergy Immunol 2019 Jan 30:1-10. Epub 2019 Jan 30.

Department of Respiratory Medicine, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Background: Transient receptor potential ankyrin 1 (TRPA1) is an ion channel known to mediate nociception and neurogenic inflammation, and to be activated by reactive oxygen and nitrogen species (ROS and RNS) produced at the sites of inflammation. Because neurogenic inflammation as well as the release of ROS and RNS are typical features of early stages of allergic responses, we hypothesized that TRPA1 may be involved in triggering and/or amplifying allergic inflammation.

Objective: This study aims at exploring the role of TRPA1 ion channel in acute ovalbumin-induced allergic inflammation in applicable murine models. Read More

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http://dx.doi.org/10.1159/000494932DOI Listing
January 2019
1 Read

Peanut Allergy in Spanish Children: Comparative Profile of Peanut Allergy versus Tolerance.

Int Arch Allergy Immunol 2019 Jan 24:1-7. Epub 2019 Jan 24.

Pediatric Allergy Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Peanut storage proteins (Ara h 1, Ara h 2, and Ara h 3) have been described as the major peanut allergens in children, although not all peanut-sensitized individuals have clinical reactivity after exposure.

Objectives: We studied the sensitization profile of peanut-allergic and peanut-tolerant children in a pediatric cohort.

Methods: The clinical features and sensitization profile to the peanut storage proteins Ara h 9 and Pru p 3 were compared between peanut-allergic and peanut-tolerant children using component-resolved diagnostics. Read More

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http://dx.doi.org/10.1159/000495579DOI Listing
January 2019
2 Reads

Efficacy of a Novel Intranasal Formulation of Azelastine Hydrochloride and Fluticasone Propionate, Delivered in a Single Spray, for the Treatment of Seasonal Allergic Rhinitis: Results from Russia.

Int Arch Allergy Immunol 2019 Jan 24:1-9. Epub 2019 Jan 24.

Research Center of Otorhinolaryngology of the Federal Biomedical Agency, Moscow, Russian Federation.

Background: The novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP) in a single spray (MP-AzeFlu) was compared with a first-line intranasal antihistamine spray (AZE) in Russian seasonal allergic rhinitis (SAR) patients.

Methods: Moderate-to-severe SAR/rhinoconjunctivitis patients (n = 149; aged 18-65 years) were randomized to receive MP-AzeFlu (137/50 μg AZE/FP per spray) or AZE (137 μg/spray), both as 1 spray/nostril twice daily, in a multicenter, open-label, 14-day, parallel-group trial. The primary outcome was change from baseline in morning and evening reflective total nasal symptom score (rTNSS). Read More

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https://www.karger.com/Article/FullText/494507
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January 2019
3 Reads

Dermatophagoides farinae Upregulates the Effector Functions of Eosinophils through αMβ2-Integrin and Protease-Activated Receptor-2.

Int Arch Allergy Immunol 2019 Jan 10:1-12. Epub 2019 Jan 10.

Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan.

Background: Even in subjects who are not sensitized to house dust mite (HDM), allergic symptoms can be aggravated by exposure to dust, suggesting that innate immune responses may be involved in these processes. Since eosinophils express pattern recognition receptors, HDM may directly upregulate eosinophil functions through these re ceptors. The objective of this study was to examine whether Dermatophagoides farinae (Df), a representative HDM, or Der f 1, a major allergen of Df, modifies the effector functions of eosinophils. Read More

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https://www.karger.com/Article/FullText/495008
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http://dx.doi.org/10.1159/000495008DOI Listing
January 2019
6 Reads

Role of Aspergillus fumigatus-Specific IgE in the Diagnosis of Allergic Bronchopulmonary Aspergillosis.

Int Arch Allergy Immunol 2019 Jan 9:1-7. Epub 2019 Jan 9.

Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou,

Introduction: Allergic bronchopulmonary aspergillosis (ABPA) has been regarded as a rare disease in China due to the lack of quantitative detection of Aspergillus fumigatus-specific IgE (sIgE). We compared the diagnostic rate of ABPA among asthma patients with or without A. fumigatus-sIgE screening tests to evaluate the benefit of the tests in diagnosing ABPA. Read More

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http://dx.doi.org/10.1159/000495365DOI Listing
January 2019
1 Read

Mastocytosis and the Fig Wasp (Blastophaga psenes).

Int Arch Allergy Immunol 2019 Jan 9:1-4. Epub 2019 Jan 9.

Sección de Alergia, Hospital Río Carrión, Palencia, Spain.

Background: Mastocytosis involves the abnormal proliferation of mast cells and clinical variability. In the case of anaphylaxis, the triggering antigen, often associated with Hymenoptera allergens, must be identified. The common fig (Ficus carica) requires the fig wasp (Blastophaga psenes) for pollination. Read More

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https://www.karger.com/Article/FullText/495303
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http://dx.doi.org/10.1159/000495303DOI Listing
January 2019
10 Reads

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis.

Int Arch Allergy Immunol 2019 Jan 4:1-10. Epub 2019 Jan 4.

Department of Otorhinolaryngology-Head & Neck Surgery, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: While early-life risk factors are known to influence the risk of allergies, the biological mechanisms underlying this observation are unclear. The aim of this study was to examine whether DNA methylation in childhood could underlie the association between early-life risk factors and allergic rhinitis (AR).

Methods: In total, 234 patients, aged 6 years, were recruited, i. Read More

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http://dx.doi.org/10.1159/000495304DOI Listing
January 2019
1 Read

Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia.

Int Arch Allergy Immunol 2019 Jan 4:1-8. Epub 2019 Jan 4.

Department of Respiratory Medicine and Allergy Center, Saitama Medical University, Saitama, Japan.

Background: Eosinophilic pneumonia (EP) is characterized by massive pulmonary infiltration by eosinophils. Although serum periostin is a novel marker for eosinophil-dominant asthma, the upregulation of periostin in the airway of asthmatics is controversial. In this study, we examined whether periostin concentrations are elevated in the bronchoalveolar lavage fluid (BALF) of patients with EP. Read More

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http://dx.doi.org/10.1159/000494623DOI Listing
January 2019
1 Read

The Diagnosis of Ceftriaxone Hypersensitivity in a Paediatric Population.

Int Arch Allergy Immunol 2019 Jan 3:1-5. Epub 2019 Jan 3.

Department of Paediatrics, Allergy Unit, Anna Meyer Children's University Hospital, Florence, Italy.

Introduction: Penicillins and cephalosporins are the most frequent causes of hypersensitivity reactions (HRs) to drugs in children. Among cephalosporins for intravenous use, ceftriaxone (CT) is the most frequently prescribed in Italy. The aims of this study were to evaluate the diagnostic methods for CT hypersensitivity in a population of children with suspected HRs to this drug and their tolerance toward amoxi-cillin/clavulanic acid (AMX/CLV). Read More

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http://dx.doi.org/10.1159/000495302DOI Listing
January 2019
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The Characteristics of Severe Chronic Upper-Airway Disease (SCUAD) in Patients with Allergic Rhinitis: A Real-Life Multicenter Cross-Sectional Italian Study.

Int Arch Allergy Immunol 2019 Jan 3:1-5. Epub 2019 Jan 3.

Consultant Physician of Professional Diseases Observatory, Procura della Repubblica, Turin, Italy.

Background: There are few studies regarding severe chronic upper-airway disease (SCUAD) that represents an important socioeconomic problem for the treatment of rhinitis and associated comorbidities, particularly asthma.

Objectives: The aim of our study is to evaluate the prevalence of this pathology in patients with allergic rhinitis (AR) in real life, to phenotype allergic patients with SCUAD, and to identify which factors are related to the severity of the disease.

Methods: We studied 113 patients with uncontrolled AR despite optimal adherence to therapy according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines in a multicenter Italian study, analyzing comorbidity, use of additional drugs, not scheduled visits, and the number of emergency room admissions. Read More

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http://dx.doi.org/10.1159/000495305DOI Listing
January 2019
2 Reads

Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology.

Int Arch Allergy Immunol 2019 13;178(2):182-191. Epub 2018 Dec 13.

Federal State Budgetary Scientific Institution "Research Institute of Fundamental and Clinical Immunology" (RIFCI), Novosibirsk, Russian Federation.

The expression of cytokine receptors has a crucial role in many cellular processes. Recent studies reported that changes of receptor expression could control the action of mediators on target cells. The initiation of different signaling pathways and, therefore, specific effects on cells, depends on certain components forming the cytokine-receptor complex. Read More

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http://dx.doi.org/10.1159/000494387DOI Listing
December 2018
1 Read

Clinical Response to Subcutaneous Dermatophagoides pteronyssinus Immunotherapy in Children with Allergic Rhinitis and Asthma Is Independent of Sensitization to Blomia tropicalis Allergens.

Int Arch Allergy Immunol 2019 13;178(2):201-210. Epub 2018 Dec 13.

Scientific Affairs, ALK A/S, Guangzhou,

Background: Dermatophagoides pteronyssinus (DP) and Blomia tropicalis (BT) are the dominant house dust mites inducing allergic diseases in tropical climates. It is not known whether the efficacy of DP subcutaneous immunotherapy (SCIT) is similar in patients sensitized to DP alone or to both DP and BT.

Method: Ninety-five children (5-17 years old) affected by asthma with rhinitis and sensitized to both DP and BT received 3 years of DP-SCIT. Read More

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http://dx.doi.org/10.1159/000494389DOI Listing
December 2018
2.673 Impact Factor

Characterization of Patients with Ibuprofen Hypersensitivity.

Int Arch Allergy Immunol 2019 13;178(2):177-181. Epub 2018 Dec 13.

Division of Allergy and Clinical Immunology, St. Michael's Hospital, University of Toronto, Toronto, Ontario,

Background: Ibuprofen is the most frequently used over-the-counter nonsteroidal anti-inflammatory drug (NSAID) in North America. While it has been commonly implicated in drug-induced hypersensitivity reactions, there is limited literature specifically on ibuprofen hypersensitivity.

Objectives: To characterize the demographics and clinical course of hypersensitivity reactions in a cohort of patients with ibuprofen allergy. Read More

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http://dx.doi.org/10.1159/000494388DOI Listing
December 2018
2 Reads

Cigarette Smoke Extract Promotes TIM4 Expression in Murine Dendritic Cells Leading to Th2 Polarization through ERK-Dependent Pathways.

Int Arch Allergy Immunol 2018 Dec 6:1-10. Epub 2018 Dec 6.

Laboratory of Clinical Immunology, Wuhan No. 1 Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan,

Smoking is considered to be the main source of indoor pollution, and it has been identified as an important environmental factor contributing to asthma onset. We know that T helper 2 (Th2) response plays a crucial role in the process of asthma disease. We have investigated the reaction of cigarette smoke extract (CSE) on Th polarization which is controlled by dendritic cells (DCs). Read More

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https://www.karger.com/Article/FullText/494505
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December 2018
12 Reads

Suspected Reaction with Cephalosporin May Be a Predictive Factor for β-Lactam Allergy in Children.

Int Arch Allergy Immunol 2018 Dec 5:1-7. Epub 2018 Dec 5.

Background: Most children diagnosed with β-lactam allergy based only on history are not truly allergic, and mislabeling leads to use of less effective and more costly alternative broader-spectrum antibiotics, significantly increasing drug resistance.

Objective: To determine the frequency and risk factors of confirmed allergy in patients with β-lactam allergy reported by parents or their doctors and evaluate cross-reactivity between β-lactams in children with confirmed allergy.

Method: Sixty-seven children with suspected β-lactam allergy were evaluated via history, sIgE measurements, skin tests, and drug provocation tests over a period of 5 years. Read More

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http://dx.doi.org/10.1159/000494506DOI Listing
December 2018
3 Reads

An Animal Model for Wheat Allergy Skin Sensitisation: A Comparative Study in Naive versus Tolerant Brown Norway Rats.

Int Arch Allergy Immunol 2019 5;178(2):106-118. Epub 2018 Dec 5.

National Food Institute, Technical University of Denmark, Kgs. Lyngby,

Background: Allergic sensitisation to foods may occur in infancy without prior oral exposure to the offending food, leading to the assumption that food allergy sensitisation may occur through the skin. Concerns have been raised regarding the safety of use of personal care products containing hydrolysed wheat proteins, since these products have been shown to induce allergy through the skin, and even cause an abrogation of an already established oral tolerance.

Objective: To establish an animal model for food allergy skin sensitisation and compare the sensitising capacity of an unmodified and an acid-hydrolysed gluten product via slightly damaged skin in naïve versus tolerant rats. Read More

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http://dx.doi.org/10.1159/000493802DOI Listing
December 2018
4 Reads

Immediate-Type Hypersensitivity Cross-Reactions to Proton Pump Inhibitors: A Descriptive Study of Data from the French National Pharmacovigilance Database.

Int Arch Allergy Immunol 2019 28;178(2):159-166. Epub 2018 Nov 28.

Clinical Pharmacology Department, Institute of Biology, CHU Nantes, Nantes, France.

Background: Proton pump inhibitors (PPIs) can trigger immediate-type hypersensitivity reactions (HSRs). Three main patterns of cross-reactivity have been identified: reactions to a single PPI, selective cross-reactions, and cross-reactions with all PPIs. Several hypotheses have been advanced, but no consensus has been reached. Read More

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https://www.karger.com/Article/FullText/493581
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November 2018
15 Reads

Effects of Migration on Allergic Diseases.

Int Arch Allergy Immunol 2019 22;178(2):128-140. Epub 2018 Nov 22.

Khoo Teck Puat-National University Children's Medical Institute, National University Health System (NUHS), Singapore, Singapore.

Studies in migrant populations provide vital opportunities to investigate the role of environmental factors in the pathogenesis of allergic disorders. Differences in allergy prevalence have been observed between migrants and native-born subjects living in the same geographical location. Immigrants who migrate from less affluent countries with lower allergy prevalence tend to have a lower prevalence of allergic disorders compared to native-born residents of the more affluent host country. Read More

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http://dx.doi.org/10.1159/000494129DOI Listing
November 2018
10 Reads

Bronchial Asthma and Bronchial Hyperresponsiveness and Their Characteristics in Patients with Common Variable Immunodeficiency.

Int Arch Allergy Immunol 2019 20;178(2):192-200. Epub 2018 Nov 20.

Department of Immunology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.

Background: Common variable immunodeficiency (CVID) is one of the most frequent primary immunodeficiencies and is characterized by disturbed immunoglobulin production and dysregulation of the immune system. Results of previous studies suggest a higher prevalence of bronchial asthma (BA) in CVID patients than in the general population. We initiated this study to evaluate lung functions and identify risk factors for BA and bronchial hyperresponsiveness (BHR) in patients with CVID. Read More

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https://www.karger.com/Article/FullText/494128
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November 2018
9 Reads

Evaluation of the Potential Risk Factors for Drug-Induced Anaphylaxis in Adult Patients.

Int Arch Allergy Immunol 2019 16;178(2):167-176. Epub 2018 Nov 16.

Division of Immunology and Allergic Diseases, Department of Internal Medicine, Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Aim: To investigate the potential risk factors in patients who have experienced anaphylaxis from drugs.

Method: The study included 281 adult patients (median age 40 years; 76.5% female) who experienced immediate types of hypersensitivity reaction to a drug. Read More

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https://www.karger.com/Article/FullText/494130
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November 2018
8 Reads

Intranasal Administration of IL-27 Ameliorates Nasal Allergic Responses and Symptoms.

Int Arch Allergy Immunol 2019 14;178(2):101-105. Epub 2018 Nov 14.

Department of Otorhinolaryngology, Nagoya City University, Nagoya, Japan.

Background: Interleukin 27 (IL-27) is an initiator of the Th1 response and inhibits inflammatory responses. In a mouse model of asthma, administration of IL-27 reduced eosinophil numbers in bronchoalveolar lavage fluid and airway hyperresponsiveness. However, it is unclear whether administration of IL-27 can inhibit symptoms of allergic diseases and allergic rhinitis as a therapeutic agent. Read More

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https://www.karger.com/Article/FullText/493398
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November 2018
11 Reads

Recent Advances in Experimental Allergy.

Int Arch Allergy Immunol 2018;177(4):281-289. Epub 2018 Nov 13.

Atopic disorders are on the rise and pose a great burden on society. A better understanding of the underlying mechanisms is required for the development of improved or novel therapeutic strategies. Here we aim to highlight recent advances in experimental allergy, with a particular focus on proposed treatment alternatives for airway disorders, atopic dermatitis, and food allergy. Read More

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http://dx.doi.org/10.1159/000494440DOI Listing
January 2019
2 Reads

Urine Bacteria-Derived Extracellular Vesicles and Allergic Airway Diseases in Children.

Int Arch Allergy Immunol 2019 9;178(2):150-158. Epub 2018 Nov 9.

Department of Pediatrics, Inha University School of Medicine, Incheon, Republic of

Background: Microbiota and human allergic airway diseases have been proven to be interrelated. Bacteria-derived extracellular vesicle (EV)s are known to play important roles in interbacterial and human-bacteria communications, but their relationship with allergies has not been examined yet. Urine EVs were investigated to determine whether they could be used as biomarkers for monitoring allergic airway diseases in children. Read More

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https://www.karger.com/Article/FullText/492677
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November 2018
19 Reads

Effect of Cellulose Powder on Human Nasal Epithelial Cell Activity and Ciliary Beat Frequency.

Int Arch Allergy Immunol 2018 Nov 8:1-9. Epub 2018 Nov 8.

Department of Otolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou,

Background: Cellulose powder (CP) has been reported as a safe and effective complementary treatment for allergic rhinitis (AR). Currently, CP has gained increasing application for clinical management worldwide, particularly in China. However, studies focusing on the effect of CP on normal human nasal epithelial cells (hNECs) and ciliary function are lacking. Read More

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https://www.karger.com/Article/FullText/493582
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November 2018
17 Reads
2.673 Impact Factor

MiR-202-5p Promotes M2 Polarization in Allergic Rhinitis by Targeting MATN2.

Int Arch Allergy Immunol 2019 8;178(2):119-127. Epub 2018 Nov 8.

Department of Otorhinolaryngology Head and Neck Surgery, Yuhuangding Hospital, Yantai, China.

Background: The aim of this study was to investigate the effect of MiR-202-5p on macrophages involved in allergic rhinitis.

Methods: Thirty allergic rhinitis patients and 10 healthy controls were recruited. Nasal lavage was utilized to collect mucosal tissues and mucus-derived macrophages. Read More

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https://www.karger.com/Article/FullText/493803
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November 2018
10 Reads
2.673 Impact Factor

Evaluation of a Standardized Bakery Product (SUTMEK) as a Potential Tool for Baked-Milk Tolerance and Immunotherapy Research Studies.

Int Arch Allergy Immunol 2019 7;178(1):1-9. Epub 2018 Nov 7.

Department of Pediatric Allergy and Immunology, Marmara University School of Medicine, Istanbul,

Background And Objectives: About 65-80% of children with IgE-mediated cow's milk allergy (CMA) can tolerate extensively heated milk. We have invested in the mass fabrication of a test product containing milk protein baked at 180°C for 30 min (SUTMEK-milk) and a milk-free placebo (SUTMEK-placebo) to carry out a standardised double-blind placebo-controlled food challenge (DBPCFC) test in patients with CMA.

Methods: We studied children with IgE-mediated CMA between 13 and 48 months of age. Read More

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https://www.karger.com/Article/FullText/492824
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November 2018
14 Reads

Recent Advances in Clinical Allergy and Immunology.

Authors:
Dagmar Simon

Int Arch Allergy Immunol 2018;177(4):324-333. Epub 2018 Nov 6.

Allergic diseases are of great concern because of their high prevalence, which is still rising in several regions, their impact on patients' physical and psychological health, the huge burden they place on patients' quality of life, as well as the socioeconomic consequences that they cause. Recent research has provided new data on both genetic and environmental risk factors of atopic/allergic diseases. The application of new technologies such as "omics" has allowed a better understanding of the pathogenesis and has helped with the identification of therapeutic targets. Read More

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https://www.karger.com/Article/FullText/494931
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January 2019
7 Reads

Omalizumab in Chronic Urticaria: An Italian Survey.

Int Arch Allergy Immunol 2019 5;178(1):45-49. Epub 2018 Nov 5.

Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

Omalizumab is approved for use in chronic spontaneous urticaria (CSU); however, it is not approved for chronic inducible urticaria (CIndU). The aim of the present study was to assess the effectiveness of omalizumab in treating CSU and CIndU in Italy. This is a multicentre prospective observational real-life study involving patients with severe urticaria capable of undergoing omalizumab therapy. Read More

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https://www.karger.com/Article/FullText/492532
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http://dx.doi.org/10.1159/000492532DOI Listing
November 2018
12 Reads

Notch Signaling Promotes Development of Allergic Rhinitis by Suppressing Foxp3 Expression and Treg Cell Differentiation.

Int Arch Allergy Immunol 2019 2;178(1):33-44. Epub 2018 Nov 2.

Department of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan,

Background: The Notch signaling pathway plays an important role in regulating human immune function, but the relationship between allergic rhinitis (AR) and Notch signaling remains unclear.

Objective: To investigate the role of Notch signaling in the pathogenesis of AR and its regulation on Foxp3-Treg cells.

Method: The sera of 100 patients with AR and 50 controls were collected to assess the differences in Notch1, Jagged1, and DLL1 (Delta-like 1) expression. Read More

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https://www.karger.com/Article/FullText/493328
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November 2018
10 Reads

Intralymphatic Immunotherapy: Update and Unmet Needs.

Int Arch Allergy Immunol 2019 2;178(2):141-149. Epub 2018 Nov 2.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Allergen-specific immunotherapy (AIT) is the only allergy treatment that confers long-term symptom amelioration for patients suffering from allergy. The most frequently used allergen application route is subcutaneous injection (SCIT), commonly taken as the gold standard, followed by sublingual (SLIT) or oral (OIT) application of allergen preparations. This is an up-to-date review of the clinical evidence for a novel route of allergen application, i. Read More

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https://www.karger.com/Article/FullText/493647
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http://dx.doi.org/10.1159/000493647DOI Listing
November 2018
13 Reads

Cross-Reactivity between Major IgE Epitopes of Family 5 Allergens from Dermatophagoides pteronyssinus and Blomia tropicalis.

Int Arch Allergy Immunol 2019 31;178(1):10-18. Epub 2018 Oct 31.

Centre for Protein Engineering, University of Liege, Liege, Belgium.

Background: The aim of this work was to understand the molecular features that trigger the cross-reactivity observed between Der p 5 from Dermatophagoides pteronyssinus, Blo t 5 from Blomia tropicalis, and Der f 5 from D. farinae.

Methods: We collected serum from 60 house dust mite (HDM)-allergic patients residing in the Dellys area of Boumerdès province in northern Algeria. Read More

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https://www.karger.com/Article/FullText/492871
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http://dx.doi.org/10.1159/000492871DOI Listing
October 2018
22 Reads

Ara h 1 and Ara h 6 Sensitization Causes Clinical Peanut Allergy in Ara h 2-Negative Individuals.

Int Arch Allergy Immunol 2019 26;178(1):66-75. Epub 2018 Oct 26.

Faculty of Medicine, University of Iceland, Reykjavík,

Background: Of the major peanut allergens, sensitivity to Ara h 2 has the highest prediction for clinical allergy. In this study, we evaluated sensitization to peanut components in Iceland and related Ara h 2-negative sensitization to clinical allergy.

Methods: Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Bet v 1 IgEs were measured (ImmunoCAP) in 220 peanut IgE (Pn-IgE)-positive serum samples. Read More

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https://www.karger.com/Article/FullText/493327
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http://dx.doi.org/10.1159/000493327DOI Listing
October 2018
13 Reads

IgE Cross-Reactivity of Cashew Nut Allergens.

Int Arch Allergy Immunol 2019 26;178(1):19-32. Epub 2018 Oct 26.

Wageningen Food and Biobased Research, Wageningen University and Research, Wageningen, The Netherlands.

Background: Allergic sensitisation towards cashew nut often happens without a clear history of eating cashew nut. IgE cross-reactivity between cashew and pistachio nut is well described; however, the ability of cashew nut-specific IgE to cross-react to common tree nut species and other Anacardiaceae, like mango, pink peppercorn, or sumac is largely unknown.

Objectives: Cashew nut allergic individuals may cross-react to foods that are phylogenetically related to cashew. Read More

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https://www.karger.com/Article/FullText/493100
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http://dx.doi.org/10.1159/000493100DOI Listing
October 2018
10 Reads

Fric Test Revisited: A Suggestion for a New Scoring System and Its Correlation with Urticaria Control Test and Dermatology Life Quality Index.

Int Arch Allergy Immunol 2019 4;178(1):76-82. Epub 2018 Oct 4.

Background: Fric test is a useful tool for the diagnosis and threshold testing for symptomatic dermographism. When threshold testing is not available, Urticaria Control Test (UCT) and Dermatology Life Quality Index (DLQI) might be used to assess disease control and quality of life (QoL) impairment, respectively.

Objectives: In this study, we aimed to describe a new scoring system for the Fric test and evaluate the correlations of Fric scores with UCT, DLQI, and other disease activity assessment scores. Read More

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http://dx.doi.org/10.1159/000492970DOI Listing
October 2018
17 Reads

Deletions in SERPING1 Lead to Lower C1 Inhibitor Function: Lower C1 Inhibitor Function Can Predict Disease Severity.

Int Arch Allergy Immunol 2019 2;178(1):50-59. Epub 2018 Oct 2.

Division of Allergy and Immunology, Department of Internal Medicine, Ege University Faculty of Medicine, Izmir, Turkey.

Background: How genotype affects phenotype in hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) has not been totally clarified. In this study, we investigated the relationship between different types of mutations and various phenotypic characteristics.

Methods: Clinical data from 81 patients from 47 families were recorded. Read More

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http://dx.doi.org/10.1159/000492583DOI Listing
October 2018
4 Reads

Low-Dose Oral Food Challenge with Hazelnut: Efficacy and Tolerability in Children.

Int Arch Allergy Immunol 2019 27;178(1):97-100. Epub 2018 Sep 27.

Allergy Unit, Meyer Children's Hospital, Department of Pediatrics, University of Florence, Florence, Italy.

Background: Hazelnut allergy (HA) is one of the more common food allergies (FAs) in Europe with a prevalence of 0.2%. The gold standard for diagnosing FA is oral food challenge (OFC) with the culprit food. Read More

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http://dx.doi.org/10.1159/000493019DOI Listing
September 2018
5 Reads

Sensitization to Common Aeroallergens in the Atopic Population of West Bengal, India: An Investigation by Skin Prick Test.

Int Arch Allergy Immunol 2019 26;178(1):60-65. Epub 2018 Sep 26.

Postgraduate Department of Zoology, Barasat Government College, Kolkata,

Background: Aeroallergen sensitization is increasing worldwide. The optimal management of allergic disease requires the identification of the allergic sensitivities of the patient. Complete data of offending aeroallergens are scant from West Bengal, India. Read More

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http://dx.doi.org/10.1159/000492584DOI Listing
September 2018
10 Reads

Antihistamines: Recommended Dosage - Divergence between Clinical Practice and Guideline Recommendations.

Int Arch Allergy Immunol 2019 25;178(1):93-96. Epub 2018 Sep 25.

The updosing of second-generation antihistamines for chronic urticaria is based on inconsistent findings. Herein, we report data on the treatment of children with chronic spontaneous urticaria (CSU) unresponsive to single doses of second-generation H(1)-antihistamines in whom an increase in antihistamine was performed without improvement and with a high prevalence of adverse events. Thus, it appears that well-controlled, well-designed clinical trials are needed to clarify which nonsedating antihistamines should be used, in what dose, and for how long in patients not responding to the standard treatment, despite the improvement in health care that guidelines help to incorporate. Read More

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https://www.karger.com/Article/FullText/492636
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http://dx.doi.org/10.1159/000492636DOI Listing
September 2018
3 Reads

Allergen Immunization Induces Major Changes in Microbiota Composition and Short-Chain Fatty Acid Production in Different Gut Segments in a Mouse Model of Lupine Food Allergy.

Int Arch Allergy Immunol 2018;177(4):311-323. Epub 2018 Sep 21.

Department of Toxicology and Risk Assessment, Norwegian Institute of Public Health, Oslo, Norway.

Background: The incidence of food allergies in western countries has increased in recent decades.

Objectives: To study the association between gut bacterial microbiota composition, short-chain fatty acids (SCFAs) and food allergy in a mouse model.

Methods: After oral immunizations with the human food allergen lupine with the adjuvant cholera toxin (CT) (or buffer in controls), sensitization and anaphylactic responses were determined. Read More

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http://dx.doi.org/10.1159/000492006DOI Listing
January 2019
3 Reads

Profile Shift in Latex Sensitization over the Last 20 Years.

Int Arch Allergy Immunol 2019 13;178(1):83-88. Epub 2018 Sep 13.

Department of Dermatology, Venereology, and Allergology, University Medical Center, Georg August University, Göttingen,

Background: Natural rubber latex (NRL) allergy is commonly diagnosed according to medical history, skin allergy tests, and serological analyses. However, skin tests are increasingly being abandoned because of (i) their time-consuming nature, (ii) latex preparations for skin tests being not commercially available, and (iii) the use of in-house prepared test solutions is becoming ever more difficult due to increasing regulatory hurdles. In this light, we have evaluated differences in the profiles of current and former patients with suspected latex allergy. Read More

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http://dx.doi.org/10.1159/000492191DOI Listing
September 2018
12 Reads

Evidence of Cross-Reactivity between Different Seed Storage Proteins from Hazelnut (Corylus avellana) and Walnut (Juglans regia) Using Recombinant Allergen Proteins.

Int Arch Allergy Immunol 2019 13;178(1):89-92. Epub 2018 Sep 13.

Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milan,

Seed storage proteins are extremely stable allergens in nuts, seeds, and legumes and are responsible for the most severe allergic reactions to these foods. The cross-reactivity between seed storage proteins from different sources has not been studied at a molecular level so far. This study aimed to ascertain the cross-reactivity between walnut and hazelnut seed storage proteins using recombinant allergens. Read More

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http://dx.doi.org/10.1159/000492399DOI Listing
September 2018
37 Reads
2.673 Impact Factor

Low Interleukin 10 Production at Birth Is a Risk Factor for Atopic Dermatitis in Neonates with Bifidobacterium Colonization.

Int Arch Allergy Immunol 2018;177(4):342-349. Epub 2018 Sep 11.

Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.

Background: Altered regulatory immune responses to microbial stimuli and intestinal colonization of beneficial bacteria early in life may contribute to the development of allergic diseases (e.g., atopic dermatitis [AD]). Read More

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http://dx.doi.org/10.1159/000492130DOI Listing
January 2019
3 Reads