4,494 results match your criteria International Archives of Allergy and Immunology[Journal]


Different Psychosocial Factors Are Associated with Seasonal and Perennial Allergies in Adults: Cross-Sectional Results of the KORA FF4 Study.

Int Arch Allergy Immunol 2019 Apr 24:1-11. Epub 2019 Apr 24.

Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München, Augsburg, Germany,

Background: Psychosocial factors are supposed to play a central role in the development of allergic diseases. Associations with seasonal and perennial forms of allergies have not been investigated, yet.

Objectives: The aim of the study was to investigate the associations of psychosocial factors (social status, depression, generalized anxiety, psychosocial stress, Type-D personality) with seasonal, perennial, and other forms of allergies in adults. Read More

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https://www.karger.com/Article/FullText/499042
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http://dx.doi.org/10.1159/000499042DOI Listing
April 2019
1 Read

Multimorbidity in Asthma, Allergic Conditions and COPD Increase Disease Severity, Drug Use and Costs: The Finnish Pharmacy Survey.

Int Arch Allergy Immunol 2019 Apr 18:1-8. Epub 2019 Apr 18.

Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Background: Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known.

Objective: To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well as drug and healthcare costs.

Methods: Nationwide Allergy Barometer Survey was carried out in the Finnish pharmacies during 1 week in September 2016. Read More

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http://dx.doi.org/10.1159/000498861DOI Listing
April 2019
1 Read

House Dust Mite-Induced Allergic Lung Inflammation Is Not Exacerbated in Sickle Cell Disease Mice.

Int Arch Allergy Immunol 2019 Apr 18:1-9. Epub 2019 Apr 18.

Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, Connecticut, USA,

Aim: Asthma appears to be a common comorbid condition in children with sickle cell disease (SCD), and such individuals may be at a higher risk for increased morbidity and mortality. However, several reports have indicated that asthma severity is not particularly high in those with SCD, and airway hyperreactivity and wheeze may be independently associated with SCD. In SCD mice, exacerbated allergic airway disease (AAD) has been observed in response to the model antigen ovalbumin (OVA). Read More

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https://www.karger.com/Article/FullText/499043
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http://dx.doi.org/10.1159/000499043DOI Listing
April 2019
2 Reads

TGF-β1 Induces Epithelial-Mesenchymal Transition of Chronic Sinusitis with Nasal Polyps through MicroRNA-21.

Int Arch Allergy Immunol 2019 Apr 12:1-17. Epub 2019 Apr 12.

Department of Otolaryngology, Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha, China,

Objectives: To characterize the epithelial-mesenchymal transition (EMT) in chronic rhinosinusitis with nasal polyps (CRSwNP) and to investigate the mechanism by which microRNA-21 (miR-21) regulates EMT in CRSwNP.

Method: (1) Tissue experiments: Mucosa tissues were collected from 13 patients with CRSwNP and 12 patients with CRS without nasal polyps (CRSsNP), as well as 11 patients without CRS (controls). Protein localization and quantification were achieved by immunofluorescence staining and Western blotting, involving the epithelial marker protein E-cadherin and the mesenchymal marker proteins α-smooth muscle actin (α-SMA), fibronectin, and vimentin. Read More

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http://dx.doi.org/10.1159/000497829DOI Listing

Oral Food Challenge in Food Protein-Induced Enterocolitis Syndrome by Fish: Is There Any Room for Improvement?

Int Arch Allergy Immunol 2019 Apr 12:1-7. Epub 2019 Apr 12.

Paediatric Allergy Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food hypersensitivity usually due to cow's milk or soy. Among the solid foods, rice is one of the most causative foods worldwide, but it varies depending on the geographic area. In the Mediterranean countries, fish is one of the most important triggers of FPIES. Read More

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http://dx.doi.org/10.1159/000497486DOI Listing
April 2019
2 Reads

Powder Cellulose in Allergic Rhinitis Management: Relevance of in vitro Findings to Real-Life Safety - Author's Reply.

Int Arch Allergy Immunol 2019 Apr 12;179(1):19-21. Epub 2019 Apr 12.

Department of Otolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, China,

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http://dx.doi.org/10.1159/000497116DOI Listing
April 2019
5 Reads

Localization of Four Allergens in Artemisia Pollen by Immunofluorescent Antibodies.

Int Arch Allergy Immunol 2019 Apr 10:1-8. Epub 2019 Apr 10.

Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Artemisia pollens have a high potential to induce allergic symptoms. Seven allergen components have been identified, but only Art v 7 has been localized in the pollen grain. This study aimed to localize the allergens in the pollen grains of 4 Artemisia spp. Read More

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https://www.karger.com/Article/FullText/497321
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http://dx.doi.org/10.1159/000497321DOI Listing
April 2019
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Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China.

Int Arch Allergy Immunol 2019 Apr 10:1-6. Epub 2019 Apr 10.

Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, China.

Background: Nasal polyps are a common health problem that can significantly impact the quality of life.

Objective: To analyze the impact of allergy and peripheral eosinophils (EOS) on the morbidity of chronic rhinosinusitis with nasal polyps (CRSwNP) in Northwest China.

Methods: A retrospective cohort of 323 patients who underwent endoscopic sinus surgery (ESS) for chronic rhinosinusitis without nasal polyps (CRSsNP) and CRSwNP in Xijing Hospital was studied between January 5, 2011, and January 4, 2015. Read More

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https://www.karger.com/Article/FullText/497384
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http://dx.doi.org/10.1159/000497384DOI Listing
April 2019
2 Reads

Sensitization to Cat: When Is Nasal Challenge Needed?

Int Arch Allergy Immunol 2019 Apr 10:1-6. Epub 2019 Apr 10.

Al Rashed Allergy Centre, Kuwait, Kuwait.

Introduction: Although the skin prick test (SPT) is a reliable diagnostic tool in perennial allergic rhinitis (PER) for patients allergic to cats, the minimum necessary SPT wheal size required to distinguish cat sensitization from true allergy remains controversial. The cat nasal challenge test (cNCT) could be considered the gold standard for detecting true cat allergy.

Aims: To assess the difference in the frequency of cNCT positivity between cat owners and non-owners and to determine an appropriate cut-off level for SPT wheal size in detecting positive cNCT in PER patients who are candidates for allergen immunotherapy (AIT) with cat allergen extracts. Read More

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https://www.karger.com/Article/FullText/496835
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http://dx.doi.org/10.1159/000496835DOI Listing
April 2019
5 Reads

Associations of P2X7 Polymorphisms with the Odds of Tuberculosis: A Meta-Analysis.

Int Arch Allergy Immunol 2019 Apr 10:1-7. Epub 2019 Apr 10.

Department of International Medicine, Xi'an Chest Hospital, Xi'an, China,

Background: Recently, the roles of purinergic receptor P2X ligand-gated ion channel 7 (P2X7) polymorphisms in tuberculosis (TB) were analyzed by some pilot studies, but the results of these studies were inconsistent. We performed this study to better assess the relationship between P2X7 polymorphisms and the odds of TB.

Methods: Eligible studies were searched in PubMed, MEDLINE, and Embase. Read More

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http://dx.doi.org/10.1159/000494728DOI Listing
April 2019
1 Read

Human Mast Cell Sensitization with IgE Increases miRNA-210 Expression.

Int Arch Allergy Immunol 2019 Apr 9:1-6. Epub 2019 Apr 9.

Department of Clinical Medicine, Aarhus University, Aarhus, Denmark,

Background: MicroRNAs (miRNAs) represent important post-transcriptional regulators with a dynamic expression profile during health and disease.

Objectives: We explored the miRNA profile of human mast cells (MCs) during sen-sitization with IgE, during activation through IgE, and relat ed it to prostaglandin D2 synthesis and histamine release.

Method: We investigated the expression pattern of 762 miRNAs during the IgE-mediated sensitization and activation of MCs cultured from CD133+ stem cells that were isolated from allergic asthmatic patients and nonatopic controls. Read More

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http://dx.doi.org/10.1159/000496513DOI Listing
April 2019
1 Read

Assessment of CYP2C9, CYP2C19, and CYP2D6 Polymorphisms in Allergic Patients with Chemical Sensitivity.

Int Arch Allergy Immunol 2019 Apr 3:1-14. Epub 2019 Apr 3.

Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Lecce, Italy,

Background: Self-reported chemical sensitivity (SCS) is characterized by adverse effects due to exposure to low levels of chemical substances. The clinical manifestations of SCS are similar to the allergy, and a high percentage of individuals with both diseases have been found. Various genes, especially genes of importance to the metabolism of xenobiotic compounds, have been associated with SCS. Read More

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http://dx.doi.org/10.1159/000497322DOI Listing
April 2019
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High-Sensitivity C-Reactive Protein and Allergic Endpoints in German Adolescents.

Int Arch Allergy Immunol 2019 Apr 3:1-6. Epub 2019 Apr 3.

Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany.

Background: Assessing high-sensitivity C-reactive protein (hs-CRP) in relation to allergic endpoints can shed light on both the mechanisms of allergic disease development and early non-communicable disease prevention. However, only a few epidemiological studies so far have investigated the relationship in children and adolescents, and the results were mixed.

Objectives: We sought to examine the interrelation between hs-CRP levels and allergic outcomes using a larger population size and a longitudinal study design. Read More

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http://dx.doi.org/10.1159/000497320DOI Listing
April 2019
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Bronchial Epithelial Cells Promote the Differentiation of Th2 Lymphocytes in Airway Microenvironment through Jagged/Notch-1 Signaling after RSV Infection.

Int Arch Allergy Immunol 2019 Apr 3:1-10. Epub 2019 Apr 3.

Respiratory Department, Xiangya Hospital, Central South University, Changsha, China,

Background: The aim of this study was to investigate the role of Notch-1 signaling through Notch-1 ligands on bronchial epithelial cells (BECs) in regulating the development of T helper 2 (Th2) lymphocytes after RSV infection.

Methods: Firstly, we analyzed the expression of cytokines and Notch-1 ligands in BECs by using real-time PCR. Then, RSV-infected BECs were co-cultured with CD4+ T cells in a transwell chamber for 48 h, and differentiation of T cells in the lower chamber was determined using flow cytometry and real-time PCR. Read More

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http://dx.doi.org/10.1159/000495581DOI Listing
April 2019
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Epicutaneous Exposure to Peanut Oil Induces Systemic and Pulmonary Allergic Reaction in Mice.

Int Arch Allergy Immunol 2019 Apr 3:1-5. Epub 2019 Apr 3.

Allergy and Immunology Unit, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: The prevalence of peanut allergy (PA) is constantly on the rise. Atopic dermatitis (AD) is a major risk factor for developing food allergy. Some bath oils and skin creams used for treating AD contain peanut oil, and it has been suggested that exposure to peanut allergens through a disrupted skin barrier is a potential cause of PA. Read More

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http://dx.doi.org/10.1159/000497382DOI Listing
April 2019
2 Reads

Maintenance-Phase Subcutaneous Immunotherapy with House Dust Mites Induces Cyclic Immunologic Effects.

Int Arch Allergy Immunol 2019 Mar 28:1-6. Epub 2019 Mar 28.

Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, Policlinico di Bari, Bari, Italy.

Background: Subcutaneous immunotherapy (SCIT) is an effective treatment of respiratory allergies including house dust mite (HDM) and Hymenoptera venom allergy. During the build-up phase, the allergen is administered weekly at increasing doses, while during the maintenance phase, it is administered at a fixed high dose every 4 weeks. Upon SCIT injection, the allergen is driven to the draining lymph nodes where it most likely induces an immune response. Read More

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http://dx.doi.org/10.1159/000496436DOI Listing
March 2019
1 Read

Powder Cellulose in Allergic Rhinitis Management: Relevance of in vitro Findings to Real-Life Safety.

Int Arch Allergy Immunol 2019 Mar 26:1-2. Epub 2019 Mar 26.

Herbal Research Centre, Battle, United Kingdom.

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http://dx.doi.org/10.1159/000496514DOI Listing
March 2019
4 Reads

Dexamethasone Promotes Keratinocyte Proliferation by Triggering Keratinocyte Growth Factor in Mast Cells.

Int Arch Allergy Immunol 2019 Mar 25:1-9. Epub 2019 Mar 25.

Department of Microbiology, College of Medicine, Ewha Womans University, Seoul, Republic of Korea,

Background: The skin is a dynamic body organ that can be activated by both central and local hypothalamic-pituitary-adrenal axis systems. This phenomenon might be the crucial explanation why stress can cause relapse of chronic inflammatory skin diseases, such as psoriasis. Here, we determined the effects of mast cells on keratinocyte proliferation under stress hormone stimulation. Read More

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http://dx.doi.org/10.1159/000494624DOI Listing

Liposomal Eye Spray Is as Effective as Antihistamine Eye Drops in Patients with Allergic Rhinoconjunctivitis Induced by Conjunctival Provocation Testing.

Int Arch Allergy Immunol 2019 Mar 25:1-9. Epub 2019 Mar 25.

Institute of Medical Statistics and Computational Biology (IMSB), Faculty of Medicine, University of Cologne, Cologne, Germany,

Background: Liposomal eye spray (LS) has been introduced for the treatment of dry eye. Whether LS can also relieve symptoms due to allergic rhinoconjunctivitis (ARC) has not yet been sufficiently investigated.

Objectives: The aim of this study was to assess the onset of action, the reduction of allergy symptoms, and the safety of LS - a nonpharmacological treatment option - compared with those of antihistamine eye drops (AD). Read More

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http://dx.doi.org/10.1159/000496938DOI Listing

Cellular and Humoral Responses to Cte f 2, a Cat Flea Allergen, in Children with Papular Urticaria.

Int Arch Allergy Immunol 2019 Mar 22:1-13. Epub 2019 Mar 22.

Allergy Section, Fundación Santa Fe de Bogotá, Faculty of Medicine, Universidad de los Andes, Bogotá, Colombia,

Background: Papular urticaria (PU) is a common insect bite skin hypersensitivity in tropical countries. In order to gain insight into its causal allergens, we aimed to evaluate cellular and humoral immune responses to the recombinant salivary antigen Cte f 2 from the cat flea Ctenocephalides felis.

Method: Sixty patients with PU and 27 healthy controls were included in this study. Read More

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http://dx.doi.org/10.1159/000496743DOI Listing
March 2019
3 Reads

Common Infections and Target Organs Associated with Chronic Granulomatous Disease in Iran.

Int Arch Allergy Immunol 2019 Mar 22:1-12. Epub 2019 Mar 22.

Cell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom,

Recurrent severe bacterial and fungal infections are characteristic features of the rare genetic immunodeficiency disorder chronic granulomatous disease (CGD). The disease usually manifests within the first years of life with an incidence of 1 in approximately 200,000 live births. The incidence is higher in Iran and Morocco where it reaches 1. Read More

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http://dx.doi.org/10.1159/000496181DOI Listing
March 2019
1 Read
2.673 Impact Factor

Identifying True Celiac Disease and Wheat Allergy in the Era of Fashion Driven Gluten-Free Diets.

Int Arch Allergy Immunol 2019 Mar 21:1-10. Epub 2019 Mar 21.

Division of Immunology and Allergy, Department of Medical Specialties, University Hospital and Faculty of Medicine, Geneva, Switzerland.

Background: Diagnosing both celiac disease (CD) and wheat allergy (WA) might be challenging due to the increasingly popular gluten-free diets.

Objectives: This study investigates the value of anti-tissue transglutaminase IgA (tTGIgA) and wheat-specific IgE (WIgE), and identifies clinical and serological features associated with CD and WA.

Method: Serological markers of autoimmunity and allergy along with medical charts of patients assessed for tTGIgA and WIgE between 2010 and 2016 were evaluated. Read More

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http://dx.doi.org/10.1159/000497115DOI Listing
March 2019
2 Reads

Evidence for a Role of TGF-β-Activated Kinase 1 and MAP3K7 Binding Protein 3 in Peanut-Specific T-Cell Responses.

Int Arch Allergy Immunol 2019 Mar 20:1-7. Epub 2019 Mar 20.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria,

Peanut allergy is considered to be the most common cause for food-induced anaphylaxis. Currently, no approved treatment is available. Avoidance is the only measure to prevent anaphylactic reactions to peanuts. Read More

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http://dx.doi.org/10.1159/000496438DOI Listing
March 2019
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A Novel Double-Blind, Placebo-Controlled Food Challenge Matrix for Milk and Raw Egg.

Int Arch Allergy Immunol 2019 Mar 20:1-9. Epub 2019 Mar 20.

Department of Dermatology, Faculty of Medicine and Health Science, Ghent University, Ghent, Belgium.

Background: The double-blind, placebo-controlled food challenge (DBPCFC) is still considered to be the gold standard in food allergy diagnosis. This test is however not common practice in routine due to several practical limitations, especially for non-IgE-mediated food allergy with its typical delayed food allergic reactions.

Objective: The aim of this study was to develop and evaluate DBPCFC matrices for the diagnosis of milk and egg allergies which can be applied at home for the diagnosis of delayed food allergic reactions. Read More

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https://www.karger.com/Article/FullText/494622
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http://dx.doi.org/10.1159/000494622DOI Listing
March 2019
4 Reads

Enhancement of Tissue Factor Expression in Monocyte-Derived Dendritic Cells by Pentraxin 3 and Its Modulation by C1 Esterase Inhibitor.

Int Arch Allergy Immunol 2019 Mar 20:1-7. Epub 2019 Mar 20.

Department of Legal Medicine, Nara Medical University, Kashihara, Japan.

Background: We have previously shown that human monocyte-derived dendritic cells (moDCs) may participate in immune system-mediated hypercoagulable state through enhanced tissue factor (TF) expression and that the complement system may be involved in this process.

Objectives: The aim of this study was to explore the role of pentraxin 3 (PTX3) and the complement system in enhanced TF expression in moDCs.

Methods: moDCs were generated from isolated human monocytes. Read More

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http://dx.doi.org/10.1159/000496744DOI Listing

Rapid Drug Desensitization with Chemotherapeutics (Platins, Taxanes, and Others): A Single-Center Retrospective Study.

Int Arch Allergy Immunol 2019 Mar 20:1-9. Epub 2019 Mar 20.

Department of Chest Disease, Division of Allergy and Clinical Immunology, Ankara University School of Medicine, Ankara, Turkey,

Background: Rapid drug desensitization (RDD) induces a temporary tolerance to chemotherapeutics that induce hypersensitivity reactions (HSRs).

Purpose: Our objective is to report our experience with RDD to platins, taxanes, etoposide, doxorubicin, and irinotecan.

Methods: The study was conducted as a retrospective chart review of patients with symptoms of HSRs to chemotherapeutics. Read More

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http://dx.doi.org/10.1159/000496745DOI Listing
March 2019
2 Reads

Serum Baseline Tryptase Level as a Marker for the Severity of Anaphylaxis.

Int Arch Allergy Immunol 2019 Mar 20:1-8. Epub 2019 Mar 20.

Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil,

Background: Anaphylaxis is a severe and potentially fatal allergic disease or hypersensitivity reaction with variable clinical presentation. Biomarkers in anaphylaxis could be useful to improve diagnosis, to allow endotyping of patients, and to predict risk.

Objective: To investigate the role of serum basal tryptase (sBT) levels in the management of patients with anaphylaxis. Read More

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http://dx.doi.org/10.1159/000497235DOI Listing
March 2019
2 Reads

Triamcinolone Acetonide versus Fluticasone Propionate in the Treatment of Perennial Allergic Rhinitis: A Randomized, Parallel-Group Trial.

Int Arch Allergy Immunol 2019 Mar 15:1-10. Epub 2019 Mar 15.

Department of Clinical Allergology of Russian Medical Academy of Postdiploma Education, Moscow, Russian Federation.

Background: Intranasal sprays are recommended as targeted therapy for allergic rhinitis (AR). Triamcinolone acetonide is a nasal corticosteroid preparation indicated for the treatment of seasonal and perennial AR (PAR) in different countries worldwide.

Objectives: In order to determine the efficacy of triamcinolone acetonide in the treatment of PAR, the non-inferiority of triamcinolone acetonide to fluticasone propionate was assessed in Russian adults. Read More

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http://dx.doi.org/10.1159/000497160DOI Listing
March 2019
4 Reads

Effects of an Oral CRTh2 Antagonist (AZD1981) on Eosinophil Activity and Symptoms in Chronic Spontaneous Urticaria.

Int Arch Allergy Immunol 2019 Mar 15:1-10. Epub 2019 Mar 15.

Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Background: Approximately 50% of patients with chronic spontaneous urticaria (CSU) experience symptoms that are not fully controlled by antihistamines, indicating an unmet clinical need.

Objective: To evaluate the effects of the selective CRTh2 antagonist AZD1981 on symptoms and targeted leukocytes in adults with persistent CSU despite treatment with H1-antihistamines.

Methods: We performed a single-center, randomized, placebo-controlled study involving adult CSU subjects with symptoms despite daily antihistamines. Read More

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http://dx.doi.org/10.1159/000496162DOI Listing
March 2019
1 Read

Functional Role of MicroRNAs in Thymocyte Development.

Int Arch Allergy Immunol 2019 12;178(4):315-322. Epub 2019 Mar 12.

Special Key Laboratory of Gene Detection and Therapy of the Guizhou Province, Zunyi Medical University, Zunyi, China,

MicroRNAs (miRNAs) are a class of endogenous noncoding single-stranded RNAs widely distributed in eukaryotes, which can modulate target gene expression at posttranscriptional level and participate in cell proliferation, differentiation, and apoptosis. Related studies have shown that mi-RNAs are instrumental to many aspects of immunity, including various levels of T-cell immunity. In addition, multiple miRNAs have been ascribed key roles in T-cell development, differentiation, and function. Read More

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http://dx.doi.org/10.1159/000496093DOI Listing
March 2019
4 Reads
2.673 Impact Factor

The Clinical Relevance of Natural Rubber Latex-Specific IgE in Patients Sensitized to Timothy Grass Pollen.

Int Arch Allergy Immunol 2019 8;178(4):345-354. Epub 2019 Mar 8.

Allergy Clinic, Department of Dermatology and Allergy, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: In pollen-allergic patients, cross-reacting allergens including cross-reactive carbohydrate determinants (CCDs) and profilins may result in positive natural rubber latex (NRL)-specific IgE (sIgE) antibody tests but the relationship between this sensitization and clinical NRL type 1 allergy is poorly described.

Objective: The aims of this study were to determine the frequency and clinical relevance of NRL sIgE in grass pollen-sensitized individuals and to investigate which NRL allergen components these individuals were sensitized to.

Methods: A total of 383 grass-sensitized patients answered questions about NRL allergy symptoms and their stored sera from previous investigations were analyzed for NRL sIgE. Read More

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http://dx.doi.org/10.1159/000495580DOI Listing
March 2019
1 Read

Impact of Preoperative Systemic Corticosteroids on the Histology and Diagnosis of Eosinophilic Chronic Rhinosinusitis.

Int Arch Allergy Immunol 2019 Feb 22:1-8. Epub 2019 Feb 22.

Department of Otolaryngology, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Background: The histological changes corticosteroids induce in nasal polyps, and whether these changes have an impact on the diagnosis of eosinophilic chronic rhinosinusitis (ECRS), currently remain unclear.

Objectives: A prospective controlled multicenter trial was conducted to evaluate the efficacy of the low-dose and short-term oral prednisolone (oPSL) treatment for tissue eosinophil infiltrations in ECRS.

Methods: Subjects with ECRS diagnosed by previous biopsies received a low dose of oPSL for 3 days (PSL 3) or 7 days (PSL 7) before surgery. Read More

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http://dx.doi.org/10.1159/000496437DOI Listing
February 2019

TNF-TNFR2 Signaling Inhibits Th2 and Th17 Polarization and Alleviates Allergic Airway Inflammation.

Int Arch Allergy Immunol 2019 14;178(3):281-290. Epub 2019 Feb 14.

Department of Respiratory Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: TNF-TNFR2 signaling has been indicated to be involved in CD4+ T lymphocyte differentiation. However, its role in allergic airway inflammation is not well understood.

Objectives: The aim of this study was to investigate the role of TNF-TNFR2 signaling in allergic airway inflammation. Read More

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http://dx.doi.org/10.1159/000493583DOI Listing
February 2019

Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis.

Int Arch Allergy Immunol 2019 Feb 14:1-6. Epub 2019 Feb 14.

Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Republic of Korea,

Background: We conducted a meta-analysis to determine a practical observation time for detecting a biphasic reaction after resolution of the initial anaphylactic reaction.

Methods: A systematic literature search identified studies on adult patients with anaphylaxis and a subsequent biphasic reaction due to various causes that contained sufficient data to extract outcomes. The outcomes were pooled using a random-effects model. Read More

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http://dx.doi.org/10.1159/000496092DOI Listing
February 2019
2 Reads

Patterns in Google Trends Terms Reporting Rhinitis and Ragweed Pollen Season in Ukraine.

Int Arch Allergy Immunol 2019 13;178(4):363-369. Epub 2019 Feb 13.

University Hospital, Montpellier, France.

Background: Google Trends (GT) may represent a new approach to assessing pollen allergy. However, the development of a pan-European sentinel network has raised a problem of translating terms in different languages. A precise definition of the pollen season onset is crucial for the confirmation of a pollen allergy diagnosis and personalized treatment. Read More

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http://dx.doi.org/10.1159/000495306DOI Listing
February 2019

Beneficial Effect of Early Intervention with Garenoxacin for Bacterial Infection-Induced Acute Exacerbation of Bronchial Asthma and Chronic Obstructive Pulmonary Disease.

Int Arch Allergy Immunol 2019 13;178(4):355-362. Epub 2019 Feb 13.

Division of Allergology and Respiratory Medicine, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

Background: Chronic obstructive pulmonary disease (COPD) and asthma have similar clinical features and are both exacerbated by airway infection.

Objective: To determine whether garenoxacin mesylate hydrate (GRNX) added to the standard care for bacterial infection-induced acute exacerbation of asthma or COPD in adults has clinical benefits.

Method: This single-arm clinical trial was conducted from January 2015 to March 2016. Read More

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http://dx.doi.org/10.1159/000495761DOI Listing
February 2019
4 Reads

Preclinical Brown Norway Rat Models for the Assessment of Infant Formulas in the Prevention and Treatment of Cow's Milk Allergy.

Int Arch Allergy Immunol 2019 13;178(4):307-314. Epub 2019 Feb 13.

National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark,

Background: Infant formulas (IFs) based on hydrolysed cow's milk proteins are central in the management of cow's milk allergy (CMA) in infants and small children. New IF compositions with improved prevention and treatment properties are needed, along with appropriate preclinical animal models, to evaluate these properties before introduction into humans.

Objectives: We aimed to develop preclinical models for the assessment of the primary preventive and desensitising capacity of cow's milk IF in allergy-prone, high-IgE responder Brown Norway rats. Read More

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http://dx.doi.org/10.1159/000495801DOI Listing
February 2019

Early Introduction of Egg and Development of Egg Allergy.

Int Arch Allergy Immunol 2019 8;178(3):279-280. Epub 2019 Feb 8.

Department of Immunology, Landspitali University Hospital, Reykjavik, Iceland.

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http://dx.doi.org/10.1159/000496266DOI Listing
February 2019

Atopic Dermatitis: Collegium Internationale Allergologicum (CIA) Update 2019.

Int Arch Allergy Immunol 2019 8;178(3):207-218. Epub 2019 Feb 8.

Institute of Pharmacology, University of Bern, Bern, Switzerland.

Atopic dermatitis (AD) is a chronic inflammatory skin disease presenting with recurrent eczematous lesions and intense pruritus. It is common and affects both children and adults, often beginning in infancy. Due to the unpredictable disease course, its visible skin lesions, itching and scratching followed by sleeplessness, other associated atopic diseases, and behavioral and psychiatric disorders, AD is an immense burden for patients and caregivers. Read More

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https://www.karger.com/Article/FullText/497383
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http://dx.doi.org/10.1159/000497383DOI Listing
February 2019
10 Reads

Early Introduction of Egg and Development of Egg Allergy.

Int Arch Allergy Immunol 2019 8;178(3):277-278. Epub 2019 Feb 8.

Health Services Research and International Health, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.

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http://dx.doi.org/10.1159/000495578DOI Listing
February 2019
5 Reads

Transient Receptor Potential Ankyrin 1 Enhances Ovalbumin-Induced Acute Allergic Inflammation in Murine Models.

Int Arch Allergy Immunol 2019 30;178(3):238-247. Epub 2019 Jan 30.

Department of Respiratory Medicine, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Background: Transient receptor potential ankyrin 1 (TRPA1) is an ion channel known to mediate nociception and neurogenic inflammation, and to be activated by reactive oxygen and nitrogen species (ROS and RNS) produced at the sites of inflammation. Because neurogenic inflammation as well as the release of ROS and RNS are typical features of early stages of allergic responses, we hypothesized that TRPA1 may be involved in triggering and/or amplifying allergic inflammation.

Objective: This study aims at exploring the role of TRPA1 ion channel in acute ovalbumin-induced allergic inflammation in applicable murine models. Read More

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http://dx.doi.org/10.1159/000494932DOI Listing
January 2019
4 Reads

Peanut Allergy in Spanish Children: Comparative Profile of Peanut Allergy versus Tolerance.

Int Arch Allergy Immunol 2019 24;178(4):370-376. Epub 2019 Jan 24.

Pediatric Allergy Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Peanut storage proteins (Ara h 1, Ara h 2, and Ara h 3) have been described as the major peanut allergens in children, although not all peanut-sensitized individuals have clinical reactivity after exposure.

Objectives: We studied the sensitization profile of peanut-allergic and peanut-tolerant children in a pediatric cohort.

Methods: The clinical features and sensitization profile to the peanut storage proteins Ara h 9 and Pru p 3 were compared between peanut-allergic and peanut-tolerant children using component-resolved diagnostics. Read More

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http://dx.doi.org/10.1159/000495579DOI Listing
January 2019
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Efficacy of a Novel Intranasal Formulation of Azelastine Hydrochloride and Fluticasone Propionate, Delivered in a Single Spray, for the Treatment of Seasonal Allergic Rhinitis: Results from Russia.

Int Arch Allergy Immunol 2019 24;178(3):255-263. Epub 2019 Jan 24.

Research Center of Otorhinolaryngology of the Federal Biomedical Agency, Moscow, Russian Federation.

Background: The novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP) in a single spray (MP-AzeFlu) was compared with a first-line intranasal antihistamine spray (AZE) in Russian seasonal allergic rhinitis (SAR) patients.

Methods: Moderate-to-severe SAR/rhinoconjunctivitis patients (n = 149; aged 18-65 years) were randomized to receive MP-AzeFlu (137/50 μg AZE/FP per spray) or AZE (137 μg/spray), both as 1 spray/nostril twice daily, in a multicenter, open-label, 14-day, parallel-group trial. The primary outcome was change from baseline in morning and evening reflective total nasal symptom score (rTNSS). Read More

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https://www.karger.com/Article/FullText/494507
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http://dx.doi.org/10.1159/000494507DOI Listing
January 2019
5 Reads

Dermatophagoides farinae Upregulates the Effector Functions of Eosinophils through αMβ2-Integrin and Protease-Activated Receptor-2.

Int Arch Allergy Immunol 2019 10;178(4):295-306. Epub 2019 Jan 10.

Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan.

Background: Even in subjects who are not sensitized to house dust mite (HDM), allergic symptoms can be aggravated by exposure to dust, suggesting that innate immune responses may be involved in these processes. Since eosinophils express pattern recognition receptors, HDM may directly upregulate eosinophil functions through these re ceptors. The objective of this study was to examine whether Dermatophagoides farinae (Df), a representative HDM, or Der f 1, a major allergen of Df, modifies the effector functions of eosinophils. Read More

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https://www.karger.com/Article/FullText/495008
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http://dx.doi.org/10.1159/000495008DOI Listing
January 2019
8 Reads

Role of Aspergillus fumigatus-Specific IgE in the Diagnosis of Allergic Bronchopulmonary Aspergillosis.

Int Arch Allergy Immunol 2019 9;178(4):338-344. Epub 2019 Jan 9.

Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China,

Introduction: Allergic bronchopulmonary aspergillosis (ABPA) has been regarded as a rare disease in China due to the lack of quantitative detection of Aspergillus fumigatus-specific IgE (sIgE). We compared the diagnostic rate of ABPA among asthma patients with or without A. fumigatus-sIgE screening tests to evaluate the benefit of the tests in diagnosing ABPA. Read More

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http://dx.doi.org/10.1159/000495365DOI Listing
January 2019
3 Reads

Mastocytosis and the Fig Wasp (Blastophaga psenes).

Int Arch Allergy Immunol 2019 9;178(3):291-294. Epub 2019 Jan 9.

Sección de Alergia, Hospital Río Carrión, Palencia, Spain.

Background: Mastocytosis involves the abnormal proliferation of mast cells and clinical variability. In the case of anaphylaxis, the triggering antigen, often associated with Hymenoptera allergens, must be identified. The common fig (Ficus carica) requires the fig wasp (Blastophaga psenes) for pollination. Read More

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https://www.karger.com/Article/FullText/495303
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http://dx.doi.org/10.1159/000495303DOI Listing
January 2019
19 Reads

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis.

Int Arch Allergy Immunol 2019 4;178(4):323-332. Epub 2019 Jan 4.

Department of Otorhinolaryngology-Head & Neck Surgery, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: While early-life risk factors are known to influence the risk of allergies, the biological mechanisms underlying this observation are unclear. The aim of this study was to examine whether DNA methylation in childhood could underlie the association between early-life risk factors and allergic rhinitis (AR).

Methods: In total, 234 patients, aged 6 years, were recruited, i. Read More

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http://dx.doi.org/10.1159/000495304DOI Listing
January 2019
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Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia.

Int Arch Allergy Immunol 2019 4;178(3):264-271. Epub 2019 Jan 4.

Department of Respiratory Medicine and Allergy Center, Saitama Medical University, Saitama, Japan.

Background: Eosinophilic pneumonia (EP) is characterized by massive pulmonary infiltration by eosinophils. Although serum periostin is a novel marker for eosinophil-dominant asthma, the upregulation of periostin in the airway of asthmatics is controversial. In this study, we examined whether periostin concentrations are elevated in the bronchoalveolar lavage fluid (BALF) of patients with EP. Read More

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http://dx.doi.org/10.1159/000494623DOI Listing
January 2019
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The Diagnosis of Ceftriaxone Hypersensitivity in a Paediatric Population.

Int Arch Allergy Immunol 2019 3;178(3):272-276. Epub 2019 Jan 3.

Department of Paediatrics, Allergy Unit, Anna Meyer Children's University Hospital, Florence, Italy.

Introduction: Penicillins and cephalosporins are the most frequent causes of hypersensitivity reactions (HRs) to drugs in children. Among cephalosporins for intravenous use, ceftriaxone (CT) is the most frequently prescribed in Italy. The aims of this study were to evaluate the diagnostic methods for CT hypersensitivity in a population of children with suspected HRs to this drug and their tolerance toward amoxi-cillin/clavulanic acid (AMX/CLV). Read More

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http://dx.doi.org/10.1159/000495302DOI Listing
January 2019
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The Characteristics of Severe Chronic Upper-Airway Disease (SCUAD) in Patients with Allergic Rhinitis: A Real-Life Multicenter Cross-Sectional Italian Study.

Int Arch Allergy Immunol 2019 3;178(4):333-337. Epub 2019 Jan 3.

Consultant Physician of Professional Diseases Observatory, Procura della Repubblica, Turin, Italy.

Background: There are few studies regarding severe chronic upper-airway disease (SCUAD) that represents an important socioeconomic problem for the treatment of rhinitis and associated comorbidities, particularly asthma.

Objectives: The aim of our study is to evaluate the prevalence of this pathology in patients with allergic rhinitis (AR) in real life, to phenotype allergic patients with SCUAD, and to identify which factors are related to the severity of the disease.

Methods: We studied 113 patients with uncontrolled AR despite optimal adherence to therapy according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines in a multicenter Italian study, analyzing comorbidity, use of additional drugs, not scheduled visits, and the number of emergency room admissions. Read More

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http://dx.doi.org/10.1159/000495305DOI Listing
January 2019
6 Reads