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Cytometry A 2018 Dec;93(12):1213-1219

Faculty of the Heinrich-Heine, General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty, University Düsseldorf, Düsseldorf, North Rhine-Westphalia, Germany.

Diagnostic leukapheresis (DLA) is based on continuous centrifugation that collects mononuclear cells from peripheral blood with a density of 1.055-1.08 g/ml. Read More

Cytometry A 2018 Dec;93(12):1260-1266

Menarini Silicon Biosystems S.p.A, Bologna, Italy.

Circulating tumor cells (CTCs) are rare cells shed into the bloodstream by invasive tumors and their analysis offers a promising noninvasive tool to predict and monitor therapeutic responses. CTCs can be isolated from patient blood and their characterization at single-cell level can inform on the genomic landscape of a tumor. All CTC enrichment methods bear a burden of contaminating normal cells, which mandate a further step of purification to enable reliable downstream genetic analysis. Read More

Cytometry A 2018 Dec;93(12):1189-1196

Program in Biostatistics Bioinformatics and Epidemiology, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Western Australia.

CytoML is an R/Bioconductor package that enables cross-platform import, export, and sharing of gated cytometry data. It currently supports Cytobank, FlowJo, Diva, and R, allowing users to import gated cytometry data from commercial platforms into R. Once data are available in R, the data can be further manipulated. Read More

Cytometry A 2018 Dec;93(12):1207-1212

Amsterdam UMC, University of Amsterdam, Laboratory of Experimental Clinical Chemistry, Amsterdam, the Netherlands.

Biomarkers in the blood of cancer patients include circulating tumor cells (CTCs), tumor-educated platelets (TEPs), tumor-derived extracellular vesicles (tdEVs), EV-associated miRNA (EV-miRNA), and circulating cell-free DNA (ccfDNA). Because the size and density of biomarkers differ, blood is centrifuged to isolate or concentrate the biomarker of interest. Here, we applied a model to estimate the effect of centrifugation on the purity of a biomarker according to published protocols. Read More

J Public Health Dent 2018 Dec 14. Epub 2018 Dec 14.

Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.

Objectives: This study explored the association of children's salivary characteristics, past caries experience, birth weight, and reported maternal prenatal vitamin and mineral supplementation with the dental untreated decay of the child.

Methods: This cross-sectional study, a sub-study of Griffith University Environments for Healthy Living birth cohort study, was conducted on 174 mother-child dyads. Mother's prenatal usage of vitamin and mineral supplements; child's birthweight; salivary pH, buffering capacity, and levels of salivary MS and LB were explored as risk indicators. Read More

Nicotine Tob Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Introduction: Despite the overall decline in the prevalence of cigarette use in the United States, menthol cigarette use among smokers is rising, and evidence shows that it may lead to more detrimental effects on public health than regular cigarette use. One of the mechanisms by which nicotine sustains tobacco use and dependence is due to its cognitive enhancing properties, and basic science literature suggests that menthol may also enhance nicotine's acute effect on cognition.

Aims And Methods: The purpose of this review is to suggest that the cognitive enhancing effects of menthol may be a potentially important neuropsychological mechanism that has yet to be examined. Read More

J Infect Dis 2018 Dec 15. Epub 2018 Dec 15.

Department of Microbiology, University of Chicago, Illinois.

Staphylococcusaureus persistently colonizes the nasopharynx of about one-third of the human population, a key risk factor for community- and hospital-acquired invasive infections. Current strategies for S. aureus decolonization include topical and systemic administration of antibiotics, which is associated with selection for antibiotic resistance and posttreatment recolonization. Read More

Ann Work Expo Health 2018 Dec 14. Epub 2018 Dec 14.

Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Introduction: Interpretation of exposure measurements has evolved into a framework based on the lognormal distribution. Most available practical tools are based on traditional frequentist statistical procedures that do not satisfactorily account for censored data and are not amenable to simple probabilistic risk statements. Bayesian methods offer promising solutions to these challenges. Read More

Transl Behav Med 2018 Dec 13. Epub 2018 Dec 13.

Duluth Medical Research Institute, University of Minnesota, Duluth, MN, USA.

Early life adversities (ELAs) are shown as significant risk factors for chronic health conditions (CHCs). ELAs include multiple types of abuse such as the social abuse (peer, community, and collective violence). The purpose is to describe the relationship between childhood social abuse and chronic conditions in adulthood among a sample of adults in Tunisia and to investigate the role of obesity and tobacco use as mediators of this association. Read More

Hum Reprod 2018 Dec 14. Epub 2018 Dec 14.

Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, Brussels 1200, Belgium.

Study Question: Can vitrified baboon ovarian tissue survive >5 months after autotransplantation and subsequently restore fertility?

Summary Answer: Our results show that ovarian tissue grafts can survive at least 18 months, but fertility restoration could not be confirmed due to lack of pregnancy.

What Is Known Already: Ovarian function in baboons can be re-established after autografting of vitrified-warmed ovarian tissue fragments.

Study Design, Size, Duration: Ovaries from five adult female baboons were used for this study. Read More

J Public Health (Oxf) 2018 Dec;40(suppl_2):ii74-ii86

REACH Ethiopia, Hawassa, Ethiopia.

Background: Health extension workers (HEWs) are the key cadre within the Ethiopian Health Extension Programme extending health care to rural communities. National policy guidance supports the use of mHealth to improve data quality and use. We report on a mobile Health Management Information system (HMIS) with HEWs and assess its impact on data use, community health service provision and HEWs' experiences. Read More

J Public Health (Oxf) 2018 Dec;40(suppl_2):ii16-ii31

Department of International Public Health, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, UK.

Background: There is considerable optimism in mHealth's potential to overcome health system deficiencies, yet gender inequalities can weaken attempts to scale-up mHealth initiatives. We report on the gendered experiences of an mHealth intervention, in Southern Ethiopia, realised by the all-female cadre of Health Extension Workers (HEWs).

Methodology: Following the introduction of the mHealth intervention, in-depth interviews (n = 19) and focus group discussions (n = 8) with HEWs, supervisors and community leaders were undertaken to understand whether technology acted as an empowering tool for HEWs. Read More

PLoS One 2018 14;13(12):e0208878. Epub 2018 Dec 14.

Department of Paediatrics, the University of Melbourne, Melbourne, Australia.

Anemia is regarded as major public health problem among adolescents in Low and Middle-Income Countries (LMICs) but there is limited primary data in many countries, including Nepal. This study investigated the prevalence and correlates of anemia in a nationally representative sample of adolescents within the 2014 National Adolescent Nutrition Survey in Nepal. A total of 3780 adolescents aged 10 to 19 years were selected from a cross-sectional survey through multi-stage cluster sampling. Read More

Psychiatry Res 2018 Dec 5;271:502-509. Epub 2018 Dec 5.

The Danish National Institute of Public Health, University of Southern Denmark, Studiestraede 6, 1455 Copenhagen, Denmark. Electronic address:

This study examined the psychometric properties of the Danish WEMWBS and its short version (SWEMWBS) in a Danish population sample, and compared scores in Denmark with scores representative of three other European settings. A total of 3,508 Danish men and women aged 16-95 filled out an electronic survey. Face validity was examined by cognitive interviews. Read More

Theriogenology 2018 Dec 1;126:114-120. Epub 2018 Dec 1.

LUNAM University, Oniris, Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering, Sanitary Security of Reproduction Biotechnology Unit, Nantes, France. Electronic address:

The objectives of this study were to determine (i) whether Chlamydia (C.) abortus would adhere to the intact zona pellucida (ZP-intact) of early in vitro produced bovine embryos; (ii) whether the bacteria would adhere to the embryos (ZP-free) after in vitro infection; and (iii) the efficacy of the International Embryo Transfer Society (IETS) washing protocol. The experimentation was made twice. Read More

Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.

The Brain and Muscle Energy Group, Electron Microscopy Laboratory, Department of Oral Biology, University of Oslo, NO-0316 Oslo, Norway; Synaptic Neurochemistry and Amino Acid Transporters Labs, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences (IMB) and Healthy Brain Ageing Centre (SERTA), University of Oslo, NO-0317 Oslo, Norway; Center for Healthy Aging, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

The energy deficit hypothesis of attention-deficit/hyperactivity disorder (ADHD) suggests that low lactate production by brain astrocytes causes the symptoms of the disorder. Astrocytes are the main producers of lactate in the brain; however, skeletal muscles can produce the most lactate in the body. The lactate production by skeletal muscles increases with physical activity, as does the expression of the lactate transporter monocarboxylate transporter 1 (MCT1) at the blood-brain barrier (BBB). Read More

Nurse Educ Today 2018 Dec 7;73:83-87. Epub 2018 Dec 7.

Case Western Reserve University, United States of America. Electronic address:

Background: Despite growing demand for home care nursing, there is a growing home care workforce shortage, due in part to hospital-centric nursing curricula that lead students to undervalue of home care and community practice setting (Van Iersel et al., 2018a, 2018b).

Objectives: Articulate an international vision for the future of home care education, research, practice, and management shared by experienced home care nurses working in leadership roles. Read More

Sci Total Environ 2018 Dec 5;657:558-567. Epub 2018 Dec 5.

Forschungsinstitut für Biologischen Landbau (FiBL), Department of International Cooperation, Ackerstrasse 113, Postfach 219, 5070 Frick, Switzerland.

Farmers expect yield reduction of cash crops like cocoa when growing in agroforestry systems compared to monocultures, due to competition for resources, e.g. nutrients and water. Read More

J Theor Biol 2018 Dec 11. Epub 2018 Dec 11.

Gordon Life Science Institute, Boston, MA 02478, USA.

The structure of protein gains additional stability against various detrimental effects by the presence of disulfide bonds. The formation of correct disulfide bonds between cysteine residues ensures proper in vivo and in vitro folding of the protein. Many cysteine residues can be present in the polypeptide chain of a protein, however, not all cysteine residues are involved in the formation of a disulfide bond, and therefore, accurate prediction of these bonds is crucial for identifying biophysical characteristics of a protein. Read More

Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Department of Biochemistry, Abdul Wali Khan University, Mardan, Pakistan.

Acinetobacter baumannii, the gram-negative bacteria emerged as an extremely critical pathogen causing nosocomial and different kinds of infections. A. baumannii exhibit resistivity towards various classes of antibiotics that shows that there is a dire need to search more drug targets by exploiting the full genome of the bacteria. Read More

Travel Med Infect Dis 2018 Dec 11. Epub 2018 Dec 11.

Aix Marseille Univ, Institut de Recherche pour le Développement (IRD), Assistance Publique-Hôpitaux de Marseille (AP-HM), Service de Santé des Armées (SSA), Microbes Vecteurs Infections Tropicales et Méditerranéennes (VITROME), Institut Hospitalo-Universitaire-Méditerranée Infection (IHU-Méditerranée Infection), Marseille, France.

Background: The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) emerged in 2012 and attracted an international attention as the virus caused multiple healthcare associated outbreaks. There are reports of the role of asymptomatic individuals play in the transmission of MERS-CoV, however, the exact role is now known.

Method: The MEDLINE/PubMed and Scopus databases were searched for relevant papers published till August 2018 describing asymptomatic MERS-CoV infection. Read More

J Am Acad Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA.

Chemical peeling, or chemexfoliation, has been used for centuries to improve signs of ultraviolet light-induced sun damage. Over the last 30 years, the science behind chemical peeling has evolved, increasing our understanding of the role of peeling ingredients and treatment indications. The depth of peels is directly related to improved results and to the number of complications that can occur. Read More

J Am Acad Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA.

Once considered the gold standard for deep facial resurfacing, the classical Baker-Gordon phenol-croton oil peel has largely been replaced by formulas with lower concentrations of phenol and croton oil. The improved safety profile of deep peels has ushered in a new era in chemical peeling. Wrinkles can be improved and skin tightened with more subtle and natural results. Read More

Ann Thorac Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, Lucile Packard Children's Hospital Stanford, Clinical and Translational Research Program; Stanford University School of Medicine; Department of Cardiothoracic Surgery, Lucile Packard Children's Hospital Stanford, Clinical and Translational Research Program; Stanford University School of Medicine.

Background: Our programmatic approach to tetralogy of Fallot with major aortopulmonary collaterals emphasizes single-stage unifocalization with complete intracardiac repair during infancy. Little is known about suitability for complete repair in patients beyond infancy. We sought to analyze outcomes of our approach in older patients with previously untreated tetralogy of Fallot with major aortopulmonary collaterals. Read More

Cochrane Database Syst Rev 2018 Dec 14;12:CD011710. Epub 2018 Dec 14.

Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Hadyn Ellis Building, Maindy Road, Cardiff, UK, CF24 4HQ.

Background: Therapist-delivered trauma-focused psychological therapies are an effective treatment for post-traumatic stress disorder (PTSD). These have become the accepted first-line treatments for the disorder. Despite the established evidence-base for these therapies, they are not always widely available or accessible. Read More

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5885-5892

Jacobs Retina Center at Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego, California, United States.

Purpose: For more than 20 years, there has been an international, multidisciplinary effort to develop retinal prostheses to restore functional vision to patients blinded by retinal degeneration. We developed a novel subretinal prosthesis with 1512 optically addressed silicon nanowire photodiodes, which transduce incident light into an electrical stimulation of the remaining retinal circuitry. This study was conducted to evaluate the efficacy of optically driving the subretinal prosthesis to produce visual cortex activation via electrical stimulation of the retina. Read More

PLoS One 2018 14;13(12):e0209091. Epub 2018 Dec 14.

Natural History Museum, University of Oslo, Oslo, Norway.

Background And Aims: The bacterial leaf nodule symbiosis is a close interaction between endophytes and their plant hosts, mainly within the coffee family. The interaction between Rubiaceae species and Burkholderia bacteria is unique due to its obligate nature, high specificity, and predominantly vertical transmission of the endophytes to the next generation of host plants. This vertical transmission is intriguing since it is the basis for the uniqueness of the symbiosis. Read More

PLoS One 2018 14;13(12):e0207837. Epub 2018 Dec 14.

Department of Occupational Health, Centro Hospitalar Universitário São João, Porto, Portugal.

Introduction: Healthcare workers account for 10% of the EU's total workforce, with a significant proportion of those employed in hospitals. Musculoskeletal injuries are the predominant group of injuries in healthcare professionals due to the physical demands of their work, such as the mobilization and positioning of the dependent patients. The management of this type of problem should take into account direct and indirect costs, such as periods of incapacity for work due to illness, hiring and training of new employees during periods of absence, reduced levels of productivity and the effects on production and quality of work. Read More

PLoS One 2018 14;13(12):e0208880. Epub 2018 Dec 14.

Insect Pest Control Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, Vienna, Austria.

The development of genetic sexing strains (GSSs) based on classical genetic approaches has revolutionized the application of the sterile insect technique (SIT) against the Mediterranean fruit fly Ceratitis capitata (Wiedemann) (Diptera: Tephritidae). The global use of Mediterranean fruit fly GSS for SIT applications as part of area-wide integrated pest management (AW-IPM) programmes is testimony to their effectiveness. During recent years, transgenic sexing strains (TSSs) have been developed through genetic engineering techniques offering the possibility to produce male-only progeny by introducing female embryonic lethal genes and to increase the efficacy to identify released sterile males by means of the expression of fluorescent transgene markers. Read More

PLoS One 2018 14;13(12):e0206819. Epub 2018 Dec 14.

School of Psychology, University of New South Wales, Sydney, Australia.

Globalization is defined for individuals as their connectivity in global networks. Social identity is conceptualized as attachment and identification with a group. We measure individual involvement with global networks and local, national, and global social identity through a questionnaire. Read More

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006938. Epub 2018 Dec 14.

Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.

Background: Given that dengue disease is growing and may progress to dengue hemorrhagic fever (DHF), data on economic cost and disease burden are important. However, data for Mexico are limited.

Methodology/principal Findings: Burden of dengue fever (DF) and DHF in Mexico was assessed using official databases for epidemiological information, disabilities weights from Shepard et al, the reported number of cases and deaths, and costs. Read More

PLoS One 2018 14;13(12):e0209348. Epub 2018 Dec 14.

Department of Political and Juridical Sciences and International Studies, University of Padova, Padova, Italy.

The accumulation of scientific knowledge on calling is limited by the absence of a common theoretical and measurement framework. Many different models of calling have been proposed, and we do not know how much research results that refer to a specific model are generalizable to different theoretical accounts of calling. In this article, we investigate whether two leading models of calling tackle the same construct. Read More

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006986. Epub 2018 Dec 14.

Unidad Clínica de Leishmaniasis, Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.

Background: Case management in children with cutaneous leishmaniasis (CL) is mainly based on studies performed in adults. We aimed to determine the efficacy and harms of interventions to treat CL in children.

Methods: We conducted a systematic review of clinical trials and cohort studies, assessing treatments of CL in children (≤12 years old). Read More

Pediatr Infect Dis J 2018 Dec 13. Epub 2018 Dec 13.

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Child Health, Stellenbosch University, Cape Town.

Levofloxacin is used for the treatment and prevention of multidrug-resistant tuberculosis in children, but current adult formulations are poorly palatable. A questionnaire administered to caregivers of 27 children taking a novel 100 mg dispersible taste-masked levofloxacin tablet found the new formulation to be more palatable (69%) and easier to prepare (81%) than the adult formulation. This formulation may assist children to better adhere to anti-tuberculous therapy. Read More

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S93-S113

Department of Cellular Pathology, Barts Health NHS Trust, London (N.S.) Department of Cellular Pathology, Birmingham Women's NHS Trust, Birmingham (L.H.) Department of Pathology, Belfast Health and Social Care Trust, Belfast (W.G.M.), UK Division of Anatomic Pathology, Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania (R.Z.) Department of Pathology, Mexico City Hospital of Oncology, Mexico City, Mexico (I.A.-C.) Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada (M.A.D.) Department of Pathology, Wayne State University, Detroit, Michigan (R.A.-F.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (E.E., A.M.) Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School (J.L.H.) Department of Pathology, Brigham and Women's Hospital, Harvard Medical School (M.N.) Department of Pathology, Massachusetts General Hospital, Harvard Medical School (E.O.), Boston, Massachusetts Division of Gynecologic, Breast & Perinatal Pathology, University Hospital Leipzig, Leipzig (L.-C.H.) Institute of Pathology, University Hospital of Tübingen, Tübingen (A.S.), Germany Department of Anatomical Pathology, University of Maryland, College Park, Maryland (O.I.) Pathological Oncology Group and Pathology Department, University Hospital of Arnau de Vilanova, Lleida (X.M.-G.) Department of Pathology, Hospital Clinic of Barcelona, ISGlobal, Barcelona Center for International Health Research, University of Barcelona, Barcelona (J.O.), Spain Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan (Y.M.) Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (V.P.) Department of Pathology, Women and Infants Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island (M.R.Q.) Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (C.M.Q.) Department of Pathology, University of California, San Francisco, San Francisco, California (C.Z.).

Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die of their disease, with a projected increase in both incidence and mortality over the next few decades. The aim of accurate prognostication is to ensure that patients receive optimal treatment and are neither overtreated nor undertreated, thereby improving patient outcomes overall. Patients with EC can be categorized into prognostic risk groups based on clinicopathologic findings. Read More

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S64-S74

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York (R.A.S, K.J.P.) Department of Pathology, Stony Brook Hospital, SUNY, Stony Brook (C.T.), New York Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Pathology Department, University Hospital Arnau de Vilanova and University Hospital of Bellvitge, Biomedical Research Institute, and Bellvitge Biomedical Institute, University of Lleida, CIBERONC, Spain (X.M.-G.) Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts (E.O.) Department of Pathology, Yale School of Medicine and the Yale School of Public Health, New Haven, Connecticut (V.P.) Department of Oncology-Pathology, Karolinska Institutet and Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden (J.C.) Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (W.G.M.) Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada (C.B.G.).

In this review, we sought to address 2 important issues in the diagnosis of endometrial carcinoma: how to grade endometrial endometrioid carcinomas and how to incorporate the 4 genomic subcategories of endometrial carcinoma, as identified through The Cancer Genome Atlas, into clinical practice. The current International Federation of Gynecology and Obstetrics grading scheme provides prognostic information that can be used to guide the extent of surgery and use of adjuvant chemotherapy or radiation therapy. We recommend moving toward a binary scheme to grade endometrial endometrioid carcinomas by considering International Federation of Gynecology and Obstetrics defined grades 1 and 2 tumors as "low grade" and grade 3 tumors as "high grade. Read More

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S40-S63

Department of Pathology, Memorial Sloan Kettering Cancer Center (R.M., R.A.S.) New York University Medical Center and School of Medicine, Tisch Hospital (K.M.), New York Department of Pathology, University Hospital, Stony Brook School of Medicine, Stony Brook (C.T.), New York Department of Pathology, Oslo University Hospital, Norwegian Radium Hospital; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway (B.D.) Department of Pathology, University of California San Diego, San Diego (O.F.) Department of Pathology, Cedars-Sinai Medical Center, Los Angeles (J.K.L.R.), California Department of Pathology, Karolinska Institutet, Stockholm, Sweden (J.A.C.) Department of Pathology, Brigham and Women's Hospital, Harvard Medical School (C.P.C.) Department of Pathology, Massachussetts General Hospital, Harvard Medical School (E.O.), Boston, Massachussetts Department of Pathology, University of British Columbia, Vancouver (C.B.G., J.A.I.) Department of Laboratory Medicine, Pathology and Medical Genetics, Royal Jubilee Hospital, Victoria (J.A.I.), BC, Canada Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, Hospital University Arnau de Vilanova; and Department of Pathology, Hospital University de Bellvitge, IRBLLEIDA, IDIBELL, University of Lleida, CIBERONC, Barcelona, Spain (X.M.-G.) Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (W.G.M.) Department of Pathology and Obstetrics and Gynecology, Yale School of Medicine and Yale School of Publich Health, New Haven, Connecticut (V.P.) Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland (P.N.S.) Department of Pathology, KEMH and School for Women's and Infants' Health, University of Western Australia, Perth, WA, Australia (C.J.R.S.).

This review of challenging diagnostic issues concerning high-grade endometrial carcinomas is derived from the authors' review of the literature followed by discussions at the Endometrial Cancer Workshop sponsored by the International Society of Gynecological Pathologists in 2016. Recommendations presented are evidence-based, insofar as this is possible, given that the levels of evidence are weak or moderate due to small sample sizes and nonuniform diagnostic criteria used in many studies. High-grade endometrioid carcinomas include FIGO grade 3 endometrioid carcinomas, serous carcinomas, clear cell carcinomas, undifferentiated carcinomas, and carcinosarcomas. Read More

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S25-S39

Pathology Department, University of California San Francisco, San Francisco, California (J.T.R.) Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada (C.B.G.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, University Hospital Arnau de Vilanova and Department of Pathology, University Hospital de Bellvitge, University of Lleida, IRBLLEIDA, IDIBELL, CIBERONC, Spain (X.M.G.) Department of Pathology, New York University Langone Medical Center, New York, New York (K.M.) Department of Pathology, Brigham and Women's Hospital (G.L.M.) Pathology Department, Massachusetts General Hospital (E.O.), Boston, Massachusetts Pathology Department, Yale New Haven Hospital, New Haven, Connecticut (V.P.) Department of Pathology, Johns Hopkins Medical Institutions (B.M.R.) Department of Pathology, University of Maryland School of Medicine (P.S.), Baltimore, Maryland Department of Histopathology, King Edward Memorial Hospital and School for Women's and Infants' Health, University of Western Australia, Perth, Australia (C.J.R.S.) Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK (W.G.M.).

This article provides practical recommendations developed from the International Society of Gynecological Pathologists Endometrial Carcinoma Project to address 4 issues that may arise in the diagnosis of uterine corpus low-grade endometrioid carcinoma: (1) The distinction between atypical hyperplasia and low-grade endometrioid carcinoma. (2) The distinction between low-grade endometrioid carcinoma and serous carcinoma. (3) The distinction between corded and hyalinized or spindle cell variants of low-grade endometrioid carcinoma and carcinosarcoma. Read More

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S9-S24

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M., E.D.E.) Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School (J.L.H.) Department of Pathology, Massachusetts General Hospital and Harvard Medical School (E.O.), Boston, Massachusetts Department of Pathology, Wayne State University, Detroit, Michigan (R.A.F.) Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (C.M.Q.) Department of Cellular Pathology, Barts Health NHS Trust, London (N.S.) Department of Cellular Pathology, Birmingham Women's NHS Trust, Birmingham (L.H.), UK Division of Gynecologic, Breast and Perinatal Pathology, University Hospital, Leipzig (L.C.H.) Institute of Pathology, University Hospital of Tübingen, Tübingen (A.S.), Germany Department of Pathology, Hospital de Oncología Siglo XXI, Mexico City, Mexico City, Mexico (I.A.C.) Department of Pathology, Hospital Universitari de Bellvitge and Hospital Universitari de Arnau de Vilanova, Idibell, Irblleida, and Universitat de Lleida, Ciberonc (X.M.G.) Department of Pathology, Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona (J.O.), Spain Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Alberta, Canada (M.D.) Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (V.P.) Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan (Y.M.) Department of Pathology, Women and Infants Hospital and The Warren Alpert Medical School of Brown University, Providence, Rhode Island (M.R.Q.) Division of Anatomic Pathology, Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania (R.Z.) Department of Pathology, University of California, San Francisco, San Francisco, California (C.Z.) Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (W.G.M.).

Endometrial cancer is the most common gynecologic neoplasm in developed countries; however, updated universal guidelines are currently not available to handle specimens obtained during the surgical treatment of patients affected by this disease. This article presents recommendations on how to gross and submit sections for microscopic examination of hysterectomy specimens and other tissues removed during the surgical management of endometrial cancer such as salpingo-oophorectomy, omentectomy, and lymph node dissection-including sentinel lymph nodes. In addition, the intraoperative assessment of some of these specimens is addressed. Read More

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S3-S8

Department of Pathology and Obstetrics and Gynecology, Yale School of Medicine and the Yale School of Public Health, New Haven, Connecticut (V.P.) Department of Pathology, Hospital University Arnau de Vilanova and University de Bellvitge, Irblleida, Idibell, University of Lleida, Ciberonc, Lleida, Spain (X.M.G.) Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (E.O.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (W.G.M.).

There have been significant advances in our understanding of the biology and classification of endometrial carcinoma, over the last few years, and the new prediction models proposed for prognostication. To accurately diagnose and stage tumors and apply these prediction models, it is necessary that there be standardized processing of specimens, and a common understanding and usage of the diagnostic terminology of endometrial carcinoma. The International Society of Gynecological Pathologists embarked on an ambitious project to achieve this goal in 2015. Read More

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S1-S2

Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (W.G.M.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Departments of Pathology, Hospital University Arnau de Vilanova and, Hospital University de Bellvitge, IRBLLEIDA, Idibell, University of Lleida, CIBERONC, Barcelona, Spain (X.M.-G.) James Homer Wright Pathology Laboratories, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts (E.O.) Department of Pathology and Obstetrics and Gynecology, Yale School of Medicine and Yale School of Public Health, New Haven, Connecticut (V.P.).

Anesth Analg 2019 Jan;128(1):19-20

Missoula Anesthesiology and The International Heart Institute of Montana, Missoula, Montana.

Int J Gynecol Pathol 2019 Jan;38(1):108-109

International Society of Gynecological Pathologists (J.T.R., C.B.G.), San Francisco, CA.

Sex Transm Dis 2018 Dec 13. Epub 2018 Dec 13.

Center for Child and Community Health Research (CCHR), Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Background: The release of the first drug for HIV pre-exposure prophylaxis (PrEP) in 2012 marked the beginning of a new era of HIV prevention. Although PrEP is highly efficacious, identifying and ultimately increasing uptake among the highest risk male subgroups remains a challenge.

Methods: Public health surveillance data from 2009-2016 was used to evaluate the risk of an HIV diagnosis following a syphilis (i. Read More

J Am Acad Orthop Surg 2018 Dec 13. Epub 2018 Dec 13.

From the Centre for Advanced Reconstruction of Extremities (C.A.R.E.), Sahlgrenska University Hospital, Department of Orthopaedics, Institute for Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden (Dr. Brånemark, Dr. Hagberg, Mrs. Kulbacka-Ortiz, and Dr. Berlin), International Centre for Osseointegration Research, Education and Surgery (iCORES), Department of Orthopaedics, University of California, San Francisco, CA (Dr. Brånemark), and the Sahlgrenska University Hospital, Department of Orthopaedics, Institute for Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden (Dr. Rydevik).

Introduction: Direct skeletal attachment of prostheses has previously been shown to improve patient-reported outcome (PRO) measures of individuals with transfemoral amputation (TFA) at 2-year follow-up. This prospective study reports the outcomes at 5-year follow-up.

Methods: A total of 51 patients (55 legs) with TFA were included in a prospective study. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1491-1494

Department of Otolaryngology, Kuang Tien General Hospital, Taichung, Taiwan.

To observe the characteristics of positional nystagmus and clinical profile of patients with positive positional test, and to explore its possible pathogenesis. One hundred and twenty-one patients with positive positional test in the vestibular function examination were enrolled in the Peking University International Hospital from January to June in 2017. According to the 2017 BPPV guidelines, patients with test positive positional nystagmus were divided into two groups: definite BPPV and the controversial syndrome. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1900-1903

Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otolaryngology, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, 100730,China.

The aim of this study is to investigate the effect of polyethylene glycol acrylate hybrid hydrogel degradation substance on nasal mucociliary transport system. In our experiment, the complex hydrogel were formed by the combination of different ratios of polyethyleneglycol diacrylate, chitosan and polyvinyl alcohol. The experiment was divided into four groups according to the international standard of medical devices. Read More

Salud Publica Mex 2018 Sep-Oct;60(5):566-578

Programa de Estudios Sociales en Salud, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo. Santiago, Chile.

Objective: To explore the social determinants of health (SDH) of international migrant children, from the perceptions of caregivers, health workers and local authorities in eight municipalities in Chile.

Materials And Methods: A secondary analysis of data was conducted from a qualitative study that took place between 2014 and 2017. The original study involved semi-structured interviews and focus groups. Read More

Vopr Virusol 2018 ;63(5):202-211

National Research Center for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Moscow, 123098, Russian Federation.

Modern chemotherapy of cytomegalovirus (CMV) infections has a very limited arsenal of first-line drugs. These are preparations of ganciclovir (GCV) belonging to the class of modified nucleosides and its metabolic precursor ganciclovir valine ester. After three-step phosphorylation, GCV, as a structural analogue of the natural nucleotide, competes with it for binding to DNA polymerase and, due to its structural features, inhibits its activity. Read More

Klin Lab Diagn 2018 ;63(1):21-27

The Federal state budget educational institution of higher education "The Pavlov First Saint Petersburg State Medical University" of Minzdrav of Russia, 197022, St. Petersburg, Russia.

The secondary hemophagocytic syndrome is a life-threatening condition characterized by non-specifc manifestations: systemic inflammatory reaction, cytopenia, liver affection, high content of ferritin in blood serum. One of manifestations of secondary hemophagocytic syndrome is decreasing of level of glycated ferritin in blood serum expressed in percentage of total level. The detection of glycated ferritin can be applied for a differentiated diagnosis with cli9nically similar conditions, including septic process. Read More