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Andrologia 2019 Apr 17:e13295. Epub 2019 Apr 17.

Deparment of Urology, University of Health Sciences, Haydarpasa Numune Research & Training Hospital, Istanbul, Turkey.

Artificial urinary sphincter (AUS) implantation is the gold standard treatment in total stress urinary incontinence (SIU). Our aim is to evaluate the effect of AUS implantation on erectile function and sexual satisfaction (SS). Fourteen patients aged 58-73 years (mean: 66. Read More

Z Geburtshilfe Neonatol 2019 Apr 17. Epub 2019 Apr 17.

Kompetenz-Centrum Qualitätssicherung / Qualitätsmanagement, MDK Baden-Württemberg, Stuttgart.

Objective: In Germany the care of newborn infants is regulated by directives of the Federal Joint Committee. Assignment to the four levels of care, with level 1 being the highest level, is based on maternal risk factors, maternal and fetal diseases, birth weight and gestational age. This article compares birth weight and gestational age limits used in Germany with international regulations. Read More

Endoscopy 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

Respiration 2019 Apr 17:1-9. Epub 2019 Apr 17.

Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.

Early detection and treatment of tuberculosis (TB) is essential to achieve the goals appointed in the WHO End TB Strategy. Tuberculous lymphadenitis (TBLA) is the most common manifestation of extrapulmonary TB, but the diagnosis can be challenging in low-incidence countries due to sparse and inconsistent clinical features, resulting in delay. We aimed to summarize and discuss the current literature on patient delay, health care delay, and total delay (i. Read More

Forensic Sci Int 2019 Mar 30;299:114-118. Epub 2019 Mar 30.

CEDAD (CEntre for applied physics, DAting and Diagnostic) Department of Mathematics and Physics "Ennio de Giorgi", University of Salento, Italy.

The determination of the age of elephant ivory is a crucial aspect in the fight against illegal ivory trade which is still a relevant problem having triggered the decline of elephant populations due to poaching in different areas of the globe. Indeed, the absolute dating of the ivory allows, in forensics practice, to establish whether a determined sample or object was obtained and imported illegally, violating the international trade ban. In this frame the use radiocarbon dating has surely a great potential and is widely used. Read More

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

International Neuroscience Institute, Rudolf-Pichlmayr-Straße 4, D - 30625 Hannover, Germany; Leibniz Institute, Germany.

Objective: In this study, we are presenting our experience using resting state functional magnetic resonsce imaging (rs-fMRI) in preoperative planning. We performed goup analysis to demonestrate the effects of brain tumor on resting state networks (RSNs) METHODS: Thirty patients with supratentorial gliomas were included in the study. Preoperative rs-fMRI and structural MRI were performed in all cases. Read More

J Ethnopharmacol 2019 Apr 14:111884. Epub 2019 Apr 14.

Department of Pharmacology, Henan University of Chinese Medicine, Zhengzhou, 450008, China.

Ethnopharmacological Relevance: Desertliving Cistanche herb was first recorded in "Shen Nong'Herbal Classic" and listed as the top grade herbal medicine in it. Phenylethanoid glycosides are indicative components for identification and content determination of Desertliving Cistanche herb in Chinese pharmacopoeia, which is also one of the main active components. In this research, we explored the mechanism of phenylethanoid glycosides of Desertliving Cistanche herb to the perimenopausal model rats. Read More

J Mol Biol 2019 Apr 14. Epub 2019 Apr 14.

International Institute of Molecular and Cell Biology, Trojdena 4, 02-109 Warsaw, Poland. Electronic address:

Specificity engineering is challenging, and particularly difficult for enzymes that have the catalytic machinery and specificity determinants in close proximity. Restriction endonucleases have been used as a paradigm for protein engineering, but successful cases are rare. Here, we present the results of a directed evolution approach to the engineering of a dimeric, blunt end cutting restriction enzyme NlaIV (GGN/NCC). Read More

Am J Sports Med 2019 Apr 17:363546519837203. Epub 2019 Apr 17.

Section of Young Adult Hip Surgery, Division of Sports Medicine, Department of Orthopaedic Surgery, Rush Medical College of Rush University, Rush University Medical Center, Chicago, Illinois, USA.

Background: The decreased hip range of motion seen in femoroacetabular impingement syndrome (FAIS) may lead to compensatory increased motion at the symphysis pubis (SP) with resultant increased stress on the joint, which can subsequently lead to osteitis pubis.

Purpose: To quantify the prevalence of SP abnormalities in patients with FAIS through the use of imaging modalities and to compare outcomes based on the presence of SP abnormalities.

Study Design: Cohort study; Level of evidence, 3. Read More

Neurourol Urodyn 2019 Apr 14;38(4):1067-1075. Epub 2019 Mar 14.

Department of Urology, Graduate School of Medicine, The University of Tokyo, Japan.

Aims: To clarify longitudinal change of lower urinary tract symptoms (LUTS) and various types of urinary incontinence following robot-assisted radical prostatectomy (RARP) using validated questionnaires.

Materials And Methods: The core lower urinary tract symptom score (CLSS) and the International Consultation on Incontinence Questionnaire (ICIQ)-Short Form (SF) questionnaires were administered to 607 consecutive, treatment-naïve men receiving RARP before and after surgery. The time course of comprehensive LUTS and various types of urinary incontinence, including stress-, urgency-, and urinary incontinence with no obvious reason, were evaluated. Read More

Am J Epidemiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.

Women comprise about half of senior epidemiologists, but little is known about whether they are also viewed as leaders (i.e., authorities) in the field. Read More

PLoS One 2019 17;14(4):e0215240. Epub 2019 Apr 17.

McGill International TB Centre, McGill University, Montreal, QC, Canada.

Background: The Tuberculin Skin Test (TST) is a relatively simple test for detecting latent tuberculosis infection (LTBI) but requires regular quality assurance to ensure proper technique for administration and reading. The objective of this study was to estimate the accuracy and reproducibility of an mhealth approach (the mTST) to measure the size of swelling immediately following TST administration (TST injection bleb) and after 48-72 hours (TST induration).

Methods: Five non-clinical and one clinical reviewer measured the size of TST injection blebs, and TST indurations using smartphone acquired photos of sites of TST administration and readings in patients, or saline injections in volunteers. Read More

PLoS One 2019 17;14(4):e0213155. Epub 2019 Apr 17.

Center for Environmental Management of Military Lands, Colorado State University, Fort Collins, Colorado, United States of America.

Clouds persistently engulf many tropical mountains at elevations cool enough for clouds to form, creating isolated areas with frequent fog and mist. Under these isolated conditions, thousands of unique species have evolved in what are known as tropical montane cloud forests (TMCF) and páramo. Páramo comprises a set of alpine ecosystems that occur above TMCF from about 11° N to 9° S along the Americas continental divide. Read More

PLoS One 2019 17;14(4):e0212939. Epub 2019 Apr 17.

Mother & Child Centre (MCH), Chantal Biya Foundation, Yaoundé, Cameroon.

Background: Vital registration data outlining causes of deaths (CoD) are important for a sustainable health system, targeted interventions and other relevant policies. There is data paucity on vital registration systems in developing countries. We assessed the leading causes and proportions of under-five deaths, and particularly those related to pneumococcal infections in Yaoundé, Cameroon, using hospital registration data. Read More

Biomol Concepts 2019 Apr 11;10(1):62-67. Epub 2019 Apr 11.

Isfahan Neuroscience Research Center, Department of Neurology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Neuromyelitis optica (NMO), also known as Devic's disease, is an autoimmune disorder of the central nervous system (CNS) in which immune system cells and antibodies primarily attack the optic nerves and the spinal cord. OX40 (CD134) is a tumor necrosis factor (TNF)-receptor family member expressed primarily on activated CD4+ and CD8+ T-cells. In an autoimmune disease, OX40 is typically up-regulated at sites of inflammation, and increases in the number of peripheral CD4+ T-cells expressing OX40. Read More

Lymphat Res Biol 2019 Apr;17(2):211-220

9 Centre for Research & Implementation of Clinical Practice, London, United Kingdom.

This study was undertaken as part of the UK LIMPRINT international study to determine the number of people with chronic edema (CO) and its impact on health services. Overall 7436 with CO were recruited in the main UK study from a range of health settings. Factors relating to subjective control of arm and leg CO were defined in the UK. Read More

Lymphat Res Biol 2019 Apr;17(2):141-146

4 Montpellier Medecine Vasculaire, EA2992, Universite Montpellier I, CHU Saint Eloi, Montpellier, France.

There is no standardized international model for specialist lymphedema services, which covers the types of lymphedema treated and the treatments provided. The aim of this study was to provide a profile of patients attending specialist lymphedema services in different countries to explore similarities and differences. The LIMPRINT core tool was used in specialist lymphedema services in the United Kingdom, France, Italy, and Turkey. Read More

Lymphat Res Biol 2019 Apr;17(2):195-201

2 Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

This was a part of LIMPRINT (Lymphoedema IMpact and PRevalence-INTernational), an international study aimed at capturing the size and impact of lymphedema and chronic edema in different countries and health services across the world. The purpose of this study was to clarify the prevalence and the impact of chronic edema in Japan. This was a two-phase facility-based study to determine the prevalence and functional impact of chronic edema in the adult population in Japan between 2014 and 2015. Read More

Lymphat Res Biol 2019 Apr;17(2):187-194

1 Copenhagen Wound Healing and Lymphoedema Centre, Bispebjerg University Hospital, Copenhagen, Denmark.

The International Lymphedema Framework developed an international study, Lymphedema Impact and Prevalence International (LIMPRINT), to estimate the prevalence and impact of chronic edema (CO) in heterogeneous populations. A validation study using the LIMPRINT methodology was undertaken in Denmark. Participants with CO were identified from inpatient services and compared with those identified within a specialist lymphedema service and three primary care settings. Read More

Lymphat Res Biol 2019 Apr;17(2):202-210

2 Lymphedema Research and Practice Center, Hacettepe University, Ankara, Turkey.

Lymphedema and chronic edema is a major health care problem in both developed and nondeveloped countries The Lymphoedema Impact and Prevelance - International (LIMPRINT) study is an international health service-based study to determine the prevalence and functional impact in adult populations of member countries of the International Lymphoedema Framework (ILF). A total of 1051 patients from eight centers in Turkey were recruited using the LIMPRINT study protocol. Data were collected using the core and module tools that assess the demographic and clinical properties as well as disability and quality of life (QoL). Read More

Lymphat Res Biol 2019 Apr;17(2):178-186

2 Parkwood Institute Research, St. Joseph's Health Care London, Lawson Health Research Institute, London, Canada.

Chronic edema/lymphedema is defined as edema present for more than 3 months. It is underrecognized and undertreated. The International Lymphedema Framework developed an international study, Lymphedema Impact and Prevalence International (LIMPRINT), to estimate the prevalence and impact of chronic edema in heterogeneous populations. Read More

Lymphat Res Biol 2019 Apr;17(2):163-167

1 CHU de Montpellier, Montpellier, France.

Chronic edema is a condition posing a high burden on patients. The primary aim of the study was to assess the health-related quality of life (QoL) of adult patients living with chronic edema. As part of an international, multicenter, prospective study, we prospectively assessed the health-related QoL of adult patients living with a chronic edema using a disease-specific tool and a generic one. Read More

Lymphat Res Biol 2019 Apr;17(2):127-134

2 Montpellier Medecine Vasculaire, EA2992, Universite Montpellier I, CHU Saint Eloi, Montpellier, France.

The acronym Limprint stands for Lymphedema IMpact and PRevalence INTernational and was run under the auspices of the International Lymphedema Framework (ILF), a charity dedicated to improving provision of care globally. The primary aim was to identify the number of people with chronic edema (chronic edema present for >3 months and due to a range of underlying etiologies and associated risk factors) within diverse health services in nine participating countries and to determine its impact using validated methods. An international protocol and sampling framework, online data capture system, and standard operating procedures were adopted. Read More

Lymphat Res Biol 2019 Apr;17(2):173-177

7 School of Social Sciences, Nottingham University, Nottingham, United Kingdom.

Australia was one of nine participating countries in the epidemiology Phase II Lymphoedema Impact and Prevalence - International (LIMPRINT) project to determine the number of people with chronic edema (CO) in local health services. Data collection occurred through questionnaire-based interviews and clinical assessment with provided LIMPRINT tools. Four different types of services across three states in Australia participated. Read More

Lymphat Res Biol 2019 Apr;17(2):147-154

2 Montpellier Medecine Vasculaire, EA2992, Universite Montpellier I, CHU Saint Eloi, Montpellier, France.

Chronic edema (CO) is believed to be a major clinical problem within community nursing services in the United Kingdom. This study was undertaken as part of the LIMPRINT international study to determine the number of people with CO and its impact on health services. Three urban-based community nursing services participated in the United Kingdom with prospective evaluation for 4 weeks of all patients receiving nursing care using a questionnaire-based interview and clinical assessment using the LIMPRINT tools. Read More

Lymphat Res Biol 2019 Apr;17(2):121-126

2 Montpellier Medecine Vasculaire, EA2992, Universite Montpellier I, CHU Saint Eloi, Montpellier, France.

Lymphedema has always been a neglected global health care problem. A central requirement for the development of any chronic disease is the clear use of public health definitions that can be used internationally to define populations. The term "lymphedema" has historically been defined as either primary, resulting from failure of lymphatic development, or secondary, following damage to the lymphatics (e. Read More

J Clin Oncol 2019 Apr 17:JCO1801575. Epub 2019 Apr 17.

17 University of Texas Southwestern Medical Center, Dallas, TX.

Purpose: The primary objective was to determine if vaginal cuff brachytherapy and chemotherapy (VCB/C) increases recurrence-free survival (RFS) compared with pelvic radiation therapy (RT) in high-intermediate and high-risk early-stage endometrial carcinoma.

Patients And Methods: A randomized phase III trial was performed in eligible patients with endometrial cancer. Eligible patients had International Federation of Gynecology and Obstetrics (2009) stage I endometrioid histology with Gynecologic Oncology Group protocol 33-based high-intermediate-risk criteria, stage II disease, or stage I to II serous or clear cell tumors. Read More

Acta Chir Belg 2019 Apr 17:1-28. Epub 2019 Apr 17.

a Department of Thoracic and Vascular Surgery , Ghent University Hospital , Ghent , Belgium.

Background: In 2009 and 2011 respectively ESVS and AHA/ASA guidelines recommended to operate patients with a symptomatic carotid artery stenosis within 14 days. This study aimed primarily to determine if an academic hospital has implemented these international guidelines about indication and timing of surgical treatment of carotid stenosis. Secondary, the influence of referral from another hospital on time from symptoms to surgery and the influence of time between neurological event and surgery on 30-day complication rate was studied. Read More

Public Underst Sci 2019 Apr 17:963662519840946. Epub 2019 Apr 17.

Consejo Superior de Investigaciones Científicas (CSIC), Spain.

This article analyses whether different institutional sources of scientific information have an impact on its credibility. Through a population-based survey experiment of a national representative sample of the Spanish public, we measure the credibility that citizens attribute to scientific information on the evolution of CO emissions disclosed by different institutional sources (business associations, government, non-government environmental organisations, international bodies and national research institutions). The findings show that an institutional credibility gap exists in science communication. Read More

J Med Econ 2019 Apr 17. Epub 2019 Apr 17.

i Modus Outcomes Ltd , Letchworth Garden City , UK.

Aims: The Anti-Clot Treatment Scale (ACTS) and Treatment Satisfaction Questionnaire for Medication version II (TSQM-II) are validated treatment satisfaction patient-reported outcome (PRO) instruments. The ACTS includes two domains: Burdens and Benefits; the TSQM-II includes four: Effectiveness, Side Effects, Convenience, and Global Satisfaction. Japanese-language versions of the ACTS and TSQM-II have been developed and linguistically validated. Read More

AJR Am J Roentgenol 2019 Apr 17:1-5. Epub 2019 Apr 17.

1 Department of Radiology, Mayo Clinic, 200 First Ave SW, Rochester, MN 55905.

The purpose of this study is to report the frequency of major bleeding after percutaneous image-guided core biopsy and its association with aspirin usage and duration of prebiopsy aspirin abstinence. A retrospective review of percutaneous image-guided core biopsies performed at our institution between September 1, 2005, and September 1, 2016, was performed ( = 30,966). Patients were excluded if aspirin usage data were missing ( = 633). Read More

Autism 2019 Apr 17:1362361319839151. Epub 2019 Apr 17.

2 University of Vermont, USA.

This study tested international similarities and differences in scores on a scale comprising 12 items identified by international mental health experts as being very consistent with the Diagnostic and Statistical Manual of Mental Disorders (5th ed.) category of autism spectrum disorder. Participants were 19,850 preschoolers in 24 societies rated by parents on the Child Behavior Checklist for Ages 1½-5; 10,521 preschoolers from 15 societies rated by caregivers/teachers on the Caregiver-Teacher Report Form, and 7380 children from 13 societies rated by both types of informant. Read More

Aust N Z J Psychiatry 2019 Apr 17:4867419844322. Epub 2019 Apr 17.

1 Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia.

Objective: The current international trend is to create large datasets with existing data and/or deposit newly collected data into repositories accessible to the scientific community. These practices lead to more efficient data sharing, better detection of small effects, modelling of confounders, establishment of sample generalizability and identification of differences between any given disorders. In Australia, to facilitate such data-sharing and collaborative opportunities, the Neurobiology in Youth Mental Health Partnership was created. Read More

Am J Sports Med 2019 Apr 17:363546519836423. Epub 2019 Apr 17.

Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA.

Background: With a steadily increasing rate of anterior cruciate ligament (ACL) injury and reconstruction in the pediatric population, disagreement remains regarding the optimal reconstruction technique for patients with ACL injury and ≥2 years of growth remaining.

Purpose: This study aims to quantify the incidence of linear and angular growth disturbance of adolescents undergoing partial transphyseal ACL reconstruction (ACLR) while assessing graft failure rates, reoperation rates, and functional outcomes in the population.

Study Design: Case series; Level of evidence, 4. Read More

Am J Respir Crit Care Med 2019 Apr 17. Epub 2019 Apr 17.

Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Division of Neonatology, Philadelphia, Pennsylvania, United States.

Rationale: Current diagnostic criteria for bronchopulmonary dysplasia rely heavily on the level and duration of oxygen therapy, do not reflect contemporary neonatal care, nor adequately predict childhood morbidity.

Objective: To determine which of 18 pre-specified, revised definitions of bronchopulmonary dysplasia, that variably define disease presence and severity according to the level of respiratory support and supplemental oxygen administered at 36 weeks postmenstrual age, best predicts death or serious respiratory morbidity through 18-26 months corrected age.

Methods: We assessed infants born <32 weeks' gestation between 2011-2015 at 18 centers of the National Institute of Child Health and Human Development Neonatal Research Network. Read More

Biochem Mol Biol Educ 2019 Apr 17. Epub 2019 Apr 17.

Department of Biochemistry, Melaka Manipal Medical College, Manipal Academy of Higher Education (MAHE), Karnataka, India.

Medical education has adopted various e-learning technologies to its aid. Addition of Google Classroom, introduced in 2014, as a Learning Management System (LMS) has provided a basic, easy to use platform. This study tested its efficacy in teaching a biochemistry module to first year MBBS students in an Indian medical school. Read More

Cytometry A 2019 Apr 17. Epub 2019 Apr 17.

Institute for Clinical Chemistry and Laboratory Medicine, University Hospital of Regensburg, 93053 Regensburg, Germany.

Ezetimibe (EZE) and glucuronidated EZE (EZE-Glu) differentially target Niemann-Pick C1-like 1 (NPC1L1) and CD13 (aminopeptidase-N) to inhibit intestinal cholesterol absorption and cholesterol processing in other cells, although the precise molecular mechanisms are not fully elucidated. Cellular effects of EZE, EZE-Glu, and the low-absorbable EZE-analogue S6130 were investigated on human monocyte-derived macrophages upon loading with atherogenic lipoproteins. EZE and S6130, but not EZE-Glu disturbed the colocalization of CD13 and its coreceptor CD64 (Fcγ receptor I) in membrane microdomains, and decreased the presence of both receptors in detergent-resistant membrane fractions. Read More

Aust N Z J Public Health 2019 Apr 17. Epub 2019 Apr 17.

Centre for Alcohol Policy Research, La Trobe University, Victoria.

Objective: This study examined the distribution of alcohol consumption in Australia, identifying the heaviest drinking 10% of the population and examining their sociodemographic characteristics and their alcohol consumption and purchasing practices.

Methods: Data came from the 2016 National Drug Strategy Household Survey and the 2013 International Alcohol Control Study. The heaviest drinking 10% of the population identified based on estimates of annual alcohol consumption. Read More

Swiss Med Wkly 2019 Apr 17;149:w20073. Epub 2019 Apr 17.

Pain Therapy Unit, Department for Anaesthesia, Surgical Intensive Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, Switzerland.

Aims Of The Study: Given the long history of underestimating chronic pain in children and adolescents, we lack valid data on its assessment and treatment. The psychological and economic burden for patients, their families and society is substantial. The aim of this study was to assess patient characteristics of the first ambulatory interdisciplinary clinic for children and adolescents with chronic pain in Switzerland and compare them with data from other international centres. Read More

JAMA Surg 2019 Apr 17. Epub 2019 Apr 17.

Research and Scientific Affairs, The Plastic Surgery Foundation, Arlington Heights, Illinois.

Importance: Optimal treatment for traumatic digit amputation is unknown.

Objective: To compare long-term patient-reported and functional outcomes between patients treated with revision amputation or replantation for digit amputations.

Design, Setting, And Participants: Retrospective cohort study at 19 centers in the United States and Asia. Read More

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):319-325. Epub 2019 Apr 11.

Department of Atherosclerosis, Heart Institute of the Hospital das Clínicas of the Faculty of Medicine of USP (InCor-HCFMUSP), São Paulo, Brasil.

Treatment of stable coronary artery disease (CAD) relies on improved prognosis and relief of symptoms. National and international guidelines on CAD support the indication of revascularization in patients with limiting symptoms and refractory to optimal medical treatment, as well as in clinical situations where there is a prognostic benefit of interventional treatment. Most of the studies that support the guidelines for indication of revascularization date back to the 1980s and1990s of the last century. Read More

Trends Psychiatry Psychother 2019 Jan-Mar;41(1):69-77. Epub 2019 Apr 11.

Programa de Pós-Graduação em Gerontologia Biomédica, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.

Objectives: To describe the process of translating and adapting the Relationship Scales Questionnaire (RSQ) from English into Brazilian Portuguese and to present the results of its test-retest reliability using the version developed for interview application.

Methodology: The process was based on the guidelines of the International Society for Pharmaeconomics and Outcomes Research (ISPOR), which propose 10 steps for the translation and cross-cultural adaptation of self-administered instruments. The original authors of the RSQ have agreed to the translation. Read More

Trends Psychiatry Psychother 2019 Jan-Mar;41(1):43-50. Epub 2019 Apr 11.

Social Determinants of Health Research Center, Babol University of Medical Sciences, Babol, Iran.

Introduction: Long-term psychodynamic psychotherapy (LTPP) emphasizes the centrality of intrapsychic and unconscious conflicts and their relation to development. Although there is evidence supporting the efficacy of LTPP in mental disorders, little research has been published on the efficacy of LTPP for depressive and anxiety disorders.

Objective: To examine whether patients with anxiety and depressive disorders demonstrate improvement in their attachment styles, defense styles, psychiatric symptoms, anxiety/depressive symptoms, and alexithymia with LTPP. Read More

Cad Saude Publica 2019 Apr 8;35(3):e00220217. Epub 2019 Apr 8.

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.

The association between Zika and microcephaly drew international attention to Brazil. The emergency situation demanded speed and collective effort by researchers worldwide, and Science was quick to investigate the disease and publish the results. Scientific knowledge was created and disseminated through collaboration in this process. Read More

Nanoscale 2019 Apr 17. Epub 2019 Apr 17.

School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164, USA.

Formaldehyde (FA) is involved in many biological processes and is closely connected with many diseases including Alzheimer's disease and cancer. Therefore, methods for sensitive and selective detection of FA in living cells are highly demanded. As a new class of carbon nanomaterials, carbon dots (CDs) have attracted great attention owing to their robust photostability, good biocompatibility and environmental friendliness. Read More

G Ital Cardiol (Rome) 2019 Apr;20(4):4-19

A.O. Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna.

In comparison with the international scenario, in Italy the penetration of several important scientific and technological innovations in the field of cardiovascular intervention appears to be inadequate both in terms of number of patients treated with respect to the actual need, and inhomogeneity between the different geographical areas of the country. One of the main institutional objectives of the Italian Society of Interventional Cardiology (SICI-GISE) is to develop a roadmap to guarantee homogeneous access throughout the whole national territory to treatments that are recommended by the major international guidelines. The present document focuses on four main areas of cardiovascular intervention: (i) transcatheter treatment of aortic valve stenosis, (ii) percutaneous mitral valve repair, (iii) prevention of cardioembolic stroke through percutaneous left atrial appendage occlusion in patients with non-valvular atrial fibrillation, (iv) optimization of coronary revascularization with the aid of the functional study of coronary lesions. Read More

Angiol Sosud Khir 2019 ;25(1):115-119

Research Institute of Emergency Medicine named after N.V. Sklifosovsky under the Moscow Health Care Department, Moscow, Russia.

Contemporary approaches to treatment of patients with dissection of the descending aorta (DA), as well as the data of international registries and guidelines are contradictory. The endovascular method of treatment of patients with descending aortic dissection has been recognized to be revolutionary. However, there seems to be no commonly accepted concept concerning appropriate use of currently available techniques of treating patients with DA dissection. Read More

Angiol Sosud Khir 2019 ;25(1):19-23

Department of Surgery, Institute of Additional Professional Education, South Ural State Medical University of the RF Ministry of Public Health, Chelyabinsk, Russia.

Cancer-associated thromboembolic complications in malignant neoplasms are commonly encountered. They deteriorate the course of the underlying disease and are frequent causes of death. The oncological patient is at high risk of not only thrombosis but haemorrhage during anticoagulant therapy. Read More

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

Med Care 2019 Apr 15. Epub 2019 Apr 15.

RTI International, Research Triangle Park, NC.

Background: Global budgets have been proposed as a way to control health care expenditures, but experience with them in the United States is limited. Global budgets for Maryland hospitals, the All-Payer Model, began in January 2014.

Objectives: To evaluate the effect of hospital global budgets on health care utilization and expenditures. Read More