4,442 results match your criteria Internal medicine journal[Journal]


Efficacy and Tolerability of Duloxetine in Patients with Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials.

Intern Med J 2019 Apr 16. Epub 2019 Apr 16.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.

Background: Knee osteoarthritis (OA) is one of the most common joint diseases, and pharmacotherapy is necessary to control its symptoms.

Aim: To evaluate efficacy and tolerability of duloxetine in patients with knee OA.

Methods: PubMed, Web of Science, Embase, Cochrane Library, and ClinicalTrials. Read More

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http://dx.doi.org/10.1111/imj.14327DOI Listing

Get With The Guidelines - Management Of COPD In EDs In Europe And Australasia is sub-optimal.

Intern Med J 2019 Apr 15. Epub 2019 Apr 15.

Tours University Hospital, Emergency Medicine Department, 37044, Tours, France and François-Rabelais University, School of Medicine, 37044, Tours, France.

Objectives: Exacerbations of chronic obstructive pulmonary disease (COPD) are common in emergency departments (ED). Guidelines recommend administration of inhaled bronchodilators, systemic corticosteroids and antibiotics along with non-invasive ventilation (NIV) for patients with respiratory acidosis. We aimed to determine compliance with guideline recommendations for patients with treated for COPD in ED in Europe (EUR) and South East Asia/Australasia (SEA) and to compare management and outcomes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imj.14323
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http://dx.doi.org/10.1111/imj.14323DOI Listing
April 2019
4 Reads

Resilience on the Run - an evaluation of a wellbeing program for medical interns.

Intern Med J 2019 Apr 16. Epub 2019 Apr 16.

Primary Care Clinical Unit, The University of Queensland, Level 8, Health Sciences Building, Building 16/ 901 , Royal Brisbane & Women's Hospital Complex, Herston, Qld, Australia, 4029.

Objective: To evaluate the acceptability and effectiveness of a resilience and wellbeing program designed for junior doctors METHODS: A prospective cohort study of 24 medical interns at a teaching hospital in regional Queensland with a control group of 29 medical interns at a second teaching hospital in regional Queensland. Survey instruments to assess psychological distress, the ProQOL and K10, were completed at baseline, at the completion of the wellbeing program, and three months after the completion of the wellbeing program at both sites.

Results: The intervention site had an older cohort and fewer participants had a regular GP compared to the control site. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imj.14324
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http://dx.doi.org/10.1111/imj.14324DOI Listing
April 2019
1 Read

How reliable is the statistical evidence for limiting saturated fat intake? A fresh look at the influential Hooper meta-analysis.

Intern Med J 2019 Apr 16. Epub 2019 Apr 16.

Human Potential Centre, Millennium Institute, Auckland University of Technology, Private Bag 92006, Auckland, 1142, New Zealand.

Introduction: Evidence from meta-analyses has been influential in deciding whether or not limiting saturated fat intake reduces the incidence of cardiovascular disease. Recently, random effects analyses have been criticised for exaggerating the influence of publication bias, and an alternative proposed which obviates this issue: "inverse-variance heterogeneity". We re-analysed the influential Hooper meta-analysis which supports limiting saturated fat intake to decide whether or not the results of the study were sensitive to the method used. Read More

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http://dx.doi.org/10.1111/imj.14325DOI Listing

Neoadjuvant Chemotherapy in Non-Metastatic Breast Cancer- A Study on Practice Trends in a Regional Cancer Treatment Service.

Intern Med J 2019 Apr 16. Epub 2019 Apr 16.

Medical Oncology, Palmerston North Hospital, New Zealand.

Aims: Neoadjuvant Chemotherapy (NACT) is increasingly used for managing locally advanced and high risk non-metastatic breast cancer(NMBC). The goal of this study is to describe trends in NACT use, assess compliance to best practice recommendations and determine treatment response rates in a regional cancer treatment service.

Method: In this retrospective cross- sectional study, electronic records of patients who underwent NACT in centres covered by the Midcentral Regional Cancer Treatment Service (RCTS) in 2013 and 2017 were reviewed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imj.14326
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http://dx.doi.org/10.1111/imj.14326DOI Listing
April 2019
2 Reads

Elevated D-dimer levels predict adverse outcomes in hospitalized elderly patients with chronic heart failure.

Intern Med J 2019 Apr 15. Epub 2019 Apr 15.

Department of Cardiology, Chinese PLA General Hospital, Beijing, China.

Background: Elevated D-dimer levels have been associated with poor outcomes in patients with cardiovascular disease. We sought to study this association in elderly patients with chronic heart failure (CHF).

Methods: We analyzed 1355 elderly patients who were admitted with CHF. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imj.14322
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http://dx.doi.org/10.1111/imj.14322DOI Listing
April 2019
2 Reads

"Cold and lonely". Emergency presentations of patients with hypothermia to a large Australian health network.

Intern Med J 2019 Apr 9. Epub 2019 Apr 9.

General Medical Unit, Alfred Health, Melbourne, Victoria, Australia.

Background: Extreme heat is a public health priority in Australia with the health effects of cold poorly studied. A record-breaking cold winter prompted an institutional investigation into the epidemiology and outcomes of hypothermic presentations.

Method: This was a retrospective cohort observational study of hypothermic emergency presentations between 7 July 2009 and 1 September 2016 with a temperature of ≤35°C. Read More

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http://dx.doi.org/10.1111/imj.14308DOI Listing
April 2019
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Dysregulation of Calcium Metabolism in Type 1 Myotonic Dystrophy.

Intern Med J 2019 Apr 9. Epub 2019 Apr 9.

Department of Internal Medicine, Logan Hospital, Brisbane, QLD, Australia.

Background: Type 1 myotonic dystrophy (DM1) patients have a higher incidence of hypercalcemia compared to the general population. The nature and effects of dysregulated calcium metabolism underpinning this phenomenon have not been fully characterised.

Aims: To determine the characteristics of dysregulated calcium metabolism in DM1 patients and its association with bone mineral density. Read More

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http://dx.doi.org/10.1111/imj.14307DOI Listing
April 2019
2 Reads

Rituximab Therapy in Interstitial Lung Disease associated with Rheumatoid Arthritis.

Intern Med J 2019 Apr 9. Epub 2019 Apr 9.

Respiratory Diseases and Lung Transplantation Unit, AOUS - Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy.

Rheumatoid Arthrtitis (RA) is a chronic systemic inflammatory disease. In this disease interstitial lung involvement (ILD) is associated with high risk of mortality. Rituximab, a monoclonal antibody directed against CD20, is effective in the treatment of articular manifestations in RA while controversial results have been reported on Rituximab efficacy in RA-ILD patients. Read More

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http://dx.doi.org/10.1111/imj.14306DOI Listing
April 2019
1 Read

Pill testing warrants assessment in careful pilot programmes.

Intern Med J 2019 Apr;49(4):419-421

Department of Addiction Medicine, St Vincent's Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/imj.14258DOI Listing

Diabetes prevalence is high in hospital patients: a Western Australia perspective.

Intern Med J 2019 Apr;49(4):551-552

Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1111/imj.14247DOI Listing

Life-threatening hyperkalaemia developing after bilateral adrenalectomy in a patient with normal kidney function.

Intern Med J 2019 Apr;49(4):546-547

Chungbuk National University Hospital, Cheongju, South Korea.

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http://dx.doi.org/10.1111/imj.14254DOI Listing
April 2019
2 Reads

Higher risk of phaeochromocytoma/paraganglioma (Phaeo-Pgl) in SDHD than SDHB carriers: an Australian cohort study.

Intern Med J 2019 Apr;49(4):529-532

Department of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.

Carriers of succinate dehydrogenase (SDHx) mutations are at risk of developing phaeochromocytomas, catecholamine secreting extra-adrenal paragangliomas and non-secretory head and neck paragangliomas and require lifelong surveillance. There is no current consensus on the optimal surveillance strategy. This study describes the outcomes of a cohort of 50 SDHx mutation carriers followed at a tertiary Australian hospital using a surveillance protocol involving annual clinical review with plasma/urine metanephrines and biennial magnetic resonance imaging from skull base to pelvis. Read More

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http://dx.doi.org/10.1111/imj.14250DOI Listing
April 2019
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Sudden infant death syndrome: current perspectives.

Intern Med J 2019 Apr;49(4):433-438

The Ritchie Centre, Hudson Institute of Medical Research and Department of Paediatrics, Monash University, Melbourne, Victoria, Australia.

Despite significant reductions in incidence since the introduction of safe infant sleeping recommendations, sudden infant death syndrome is still the major cause of neonatal death in western countries. In the United States, over 2500 infants die suddenly and unexpectedly each year with nearly 100 deaths annually in Australia. Health professionals play a critical role in advising parents how to sleep their infants safely to minimise the risk of sudden infant death syndrome and sleeping accidents. Read More

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http://dx.doi.org/10.1111/imj.14248DOI Listing
April 2019
1 Read

Author reply.

Intern Med J 2019 Apr;49(4):552

Diabetes Centre, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/imj.14255DOI Listing

Health data linkage research in Australia remains challenging.

Intern Med J 2019 Apr;49(4):539-544

Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.

Data linkage is a valuable technique for uniting information from multiple sources that relates to the same person, place, family or event. Despite its value, establishing such linkages in Australia remains challenging. Existing policies are a missed opportunity for research and innovation and engender a negative attitude among researchers when considering data linkage as a research means. Read More

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http://dx.doi.org/10.1111/imj.14244DOI Listing
April 2019
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Antimicrobial stewardship opportunities among inpatients with diabetic foot infections: microbiology results from a tertiary hospital multidisciplinary unit.

Intern Med J 2019 Apr;49(4):533-536

Department of Infectious Diseases, Fiona Stanley Hospital, Perth, Western Australia, Australia.

Among 125 inpatients with diabetic foot infections managed by a multidisciplinary foot ulcer unit, knowledge of methicillin-resistant Staphylococcus aureus colonisation status assisted decision-making to prescribe appropriately or with-hold empiric anti-methicillin-resistant Staphylococcus aureus therapy. Despite adherence to national guidelines, apparent overuse of anti-pseudomonal therapy was frequent, providing potential antimicrobial stewardship opportunities. Read More

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http://dx.doi.org/10.1111/imj.14251DOI Listing
April 2019
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Wernicke encephalopathy hearing loss and palinacousis.

Intern Med J 2019 Apr;49(4):536-539

Neurological Intervention and Imaging Service of WA (NIISwa), Royal Perth Hospital, Perth, Western Australia, Australia.

Wernicke encephalopathy (WE) is a neurological emergency that develops in the setting of thiamine deficiency, and is characterised by symptoms of confusion, ophthalmoplegia and gait ataxia. Less recognised signs and symptoms include vestibular dysfunction, hearing impairment, peripheral neuropathy, and in severe cases, coma. This case study describes a non-alcoholic patient, who presents with significant auditory and vestibular changes in addition to the classic symptoms of WE. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imj.14249
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http://dx.doi.org/10.1111/imj.14249DOI Listing
April 2019
4 Reads

Electronic cigarettes in physician practice: a complex debate.

Intern Med J 2019 Apr;49(4):438-445

Department of Thoracic Medicine, University of Queensland Thoracic Research Centre, The Prince Charles Hospital, Brisbane, Queensland, Australia.

E-cigarettes, or electronic nicotine delivery systems (ENDS), have been suggested as a potential aid for smoking cessation, but many questions about their efficacy and safety remain unanswered. Until very recently, the evidence for ENDS in smoking cessation was largely based on observational studies or randomised controlled trials with methodological flaws and did not provide adequate evidence to support strongly ENDS for smoking cessation. Concerns about the uptake of ENDS by nonsmoking populations (such as adolescents) remain. Read More

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http://dx.doi.org/10.1111/imj.14256DOI Listing
April 2019
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The use of omalizumab for treatment-refractory chronic spontaneous urticaria in a West Australian outpatient cohort.

Intern Med J 2019 Apr;49(4):526-528

Immunology Department, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

There is a lack of real-world data on the use of omalizumab in treatment-refractory chronic spontaneous urticaria (CSU). A single-centre retrospective cohort study was performed to assess the efficacy and safety of omalizumab for treatment-refractory CSU. The overall response rate of 67% is comparable with that reported in the literature. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imj.14245
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http://dx.doi.org/10.1111/imj.14245DOI Listing
April 2019
1 Read

Drug-induced liver injury secondary to Scutellaria baicalensis (Chinese skullcap).

Intern Med J 2019 Apr;49(4):544-546

Gastroenterology and Hepatology Department, Northern Health, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/imj.14252DOI Listing

Sarcoidosis following escalated BEACOPP chemotherapy for stage IV Hodgkin lymphoma.

Intern Med J 2019 Apr;49(4):547-548

Department of Haematology, Nepean Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/imj.14246DOI Listing
April 2019
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Lymphangioleiomyomatosis: diagnostic imaging in an uncommon post-menopausal presentation.

Intern Med J 2019 Apr;49(4):549-550

Department of Medicine, Goulburn Valley Health, Shepparton, Victoria, Australia.

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http://dx.doi.org/10.1111/imj.14253DOI Listing
April 2019
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End-of-life care in an Australian acute hospital: A retrospective observational study.

Intern Med J 2019 Mar 25. Epub 2019 Mar 25.

Medical School, The Australian National University, Canberra, Australia.

Background: There is a gap in knowledge about the kind and quality of care experienced by hospital patients at the end of their lives.

Aims: To document and compare the patterns in end-of-life care for patients dying across a range of different medical units in an acute care hospital.

Methods: A retrospective observational study of consecutive adult inpatient deaths between 1 July 2010 and 30 June 2014 in four different medical units of an Australian tertiary referral hospital was performed. Read More

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http://dx.doi.org/10.1111/imj.14305DOI Listing

Improving survival in patients with hepatocellular carcinoma related to chronic hepatitis C and B but not in those related to non-alcoholic steatohepatitis or alcoholic liver disease: a 20-year experience from a national programme.

Intern Med J 2019 Mar 25. Epub 2019 Mar 25.

New Zealand Liver Transplant unit (NZLTU), Auckland City Hospital, Auckland, New Zealand.

Background: Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer mortality in New Zealand due to endemic Hepatitis B (HBV) infection and recent Hepatitis C (HCV) and obesity epidemics.

Methods: All newly diagnosed cases of HCC referred to NZLTU between 1998 and 2017 were included. Data on patient demographics, liver disease aetiology, screening status and treatment modalities were collected. Read More

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http://dx.doi.org/10.1111/imj.14304DOI Listing
March 2019
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A retrospective pharmaceutical financial benefits and cost avoidance analysis of clinical trial participation in the Australian haematology setting.

Intern Med J 2019 Mar 25. Epub 2019 Mar 25.

Concord Clinical School, The University of Sydney, Sydney, New South Wales, Australia.

Background: Clinical trial participants receiving investigational new drugs (IND), which subsequently become approved by a medicines regulatory authority for its trialled indication, effectively gain free early access to efficacious treatment. Participants may also benefit from receiving approved but unsubsidised medicines. These financial benefits of clinical trial participation have not previously been defined or quantified. Read More

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http://dx.doi.org/10.1111/imj.14302DOI Listing

Management of Stroke in the Australian Indigenous Population: From Hospitals to Communities.

Intern Med J 2019 Mar 25. Epub 2019 Mar 25.

John Hunter Hospital.

Background: Ischaemic strokes lead to significant morbidity and mortality within the Australian Indigenous population, with differing management of CVA in the Indigenous and non-Indigenous populations.

Aims: To compare investigations and management of Indigenous and non-Indigenous patients presenting to a New South Wales rural referral hospital with an ischaemic CVA to the national stroke standards across inpatient and outpatient settings.

Methods: Historical cohort study of 43 Indigenous and 167 non-Indigenous patients admitted to Tamworth Rural Referral Hospital (TRRH) with an ischaemic cerebrovascular accident (CVA). Read More

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http://dx.doi.org/10.1111/imj.14303DOI Listing

Hypertriglyceridaemia-induced pancreatitis prompted by acute corticosteroid treatment: caution for clinicians.

Intern Med J 2019 Mar;49(3):411-412

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1111/imj.14228DOI Listing

So, you want to be a doctor?

Intern Med J 2019 Mar;49(3):407-408

National Cancer Centre Singapore, Singapore General Hospital, and Duke-NUS Medical School, Singapore.

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http://dx.doi.org/10.1111/imj.14217DOI Listing

Recurrence of myopericarditis triggered by Campylobacter jejuni.

Intern Med J 2019 Mar;49(3):409-411

Department of Cardiology, Royal North Shore Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/imj.14224DOI Listing

Natural history of a systemic right ventricle.

Intern Med J 2019 Mar;49(3):388-391

Green Lane Paediatric and Congenital Cardiac Services, Starship Children's Hospital, Auckland, New Zealand.

The natural history of a systemic right ventricle after an atrial switch procedure has yet to be fully characterised. We describe the case of the longest surviving patient at our institution who underwent a Mustard Baffle correction for dextro-transposition of great arteries in childhood. Over following decades he was reviewed regularly with deteriorating systemic right ventricle function. Read More

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http://dx.doi.org/10.1111/imj.14220DOI Listing
March 2019
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Palliative care in end-stage heart failure: experience of a collaborative approach in a secondary care setting.

Intern Med J 2019 Mar;49(3):404-407

Te Omanga Hospice, Lower Hutt, New Zealand.

Heart failure remains an ultimately fatal condition that causes significant symptoms as it progresses. The involvement by palliative services in this patient group has been suboptimal despite many years of guidance from international cardiac societies who recommend a palliative focus for these patients. At Hutt hospital, we have implemented a cardiology supportive care clinic in an attempt to improve the care of our advanced heart failure patients. Read More

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http://dx.doi.org/10.1111/imj.14218DOI Listing

Acute kidney injury secondary to bilateral common iliac artery aneurysms.

Intern Med J 2019 Mar;49(3):408-409

Department of Vascular Surgery, West China Hospital, Chengdu, Sichuan, China.

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http://dx.doi.org/10.1111/imj.14225DOI Listing
March 2019
2 Reads

Low positive predictive value of International Classification of Diseases, 10th Revision codes in relation to rheumatic heart disease: a challenge for global surveillance.

Intern Med J 2019 Mar;49(3):400-403

Medical School, The University of Western Australia, Perth, Western Australia, Australia.

International Classification of Diseases, 10th Revision codes for rheumatic heart disease (RHD) include valvular heart disease of unspecified origin, limiting their usefulness for estimating RHD burden. A cross-disciplinary national consultation developed an algorithm to improve RHD identification in hospital data. The algorithm has been operationalised and piloted. Read More

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http://dx.doi.org/10.1111/imj.14221DOI Listing

Evaluation of the solitary pulmonary nodule.

Intern Med J 2019 Mar;49(3):306-315

Department of Respiratory Medicine, Ipswich General Hospital, Brisbane, Queensland, Australia.

The solitary pulmonary nodule represents a common diagnostic challenge for clinicians. While most are benign, a significant number represent early, potentially curable lung cancers. With the increased utilisation of chest computed tomography, solitary pulmonary nodules are increasingly being identified and with lung cancer screening programmes now on the horizon globally, it is crucial clinicians are familiar with the evaluation and management of solitary pulmonary nodules. Read More

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http://dx.doi.org/10.1111/imj.14219DOI Listing
March 2019
3 Reads

Variation in public-funded bariatric surgery intervention rate by New Zealand region.

Intern Med J 2019 Mar;49(3):391-395

Planning, Funding and Outcomes Unit, Auckland and Waitemata District Health Boards, Auckland, New Zealand.

Inequitable access to bariatric surgery by geographical region has been reported internationally, but comparable data on provision of bariatric surgery have not previously been reported in New Zealand. We examined allocated funding and provision of bariatric surgery amongst different regions in New Zealand in the 2013/14 year, and found that there was large variation in both. This highlights that public funded bariatric surgery needs to take into account population prevalence of morbid obesity to reduce inequities by geographical region. Read More

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http://dx.doi.org/10.1111/imj.14226DOI Listing

Burden of skin disease in two remote primary healthcare centres in northern and central Australia.

Intern Med J 2019 Mar;49(3):396-399

Menzies School of Health Research, Darwin, Northern Territory, Australia.

The burden of skin infections across all age groups in remote Australian Indigenous communities is currently unknown. In a retrospective audit of 439 residents from two remote communities presenting to health clinics, skin conditions were the most common reason for presentation (1603/7392, 22%) and 330/439 (75%) residents presented at least once with a skin infection. Skin infections are an under-appreciated and dominant reason for presentation to primary healthcare centres in these indigenous communities and public health campaigns to address this should incorporate all age groups. Read More

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http://dx.doi.org/10.1111/imj.14222DOI Listing
March 2019
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Hospital admissions for acute low back pain.

Intern Med J 2019 Mar;49(3):294-296

University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/imj.14227DOI Listing
March 2019
3 Reads

Burden, access and disparities in kidney disease.

Intern Med J 2019 Mar;49(3):287-294

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

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http://dx.doi.org/10.1111/imj.14216DOI Listing
March 2019
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Why do not all living kidney donor candidates proceed to donation?

Intern Med J 2019 Mar;49(3):384-387

School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.

There are national and international guidelines for donor workup and acceptance criteria of potential living kidney donor candidates (LKDC), but there is significant variation in clinical practice. We examined our local practice in assessing potential LKDC against current guidelines; nearly all of our accepted donors met these guidelines. LKDC who did not proceed to donation had an identified health issue (60%), the presence of risk factors for long-term end-stage kidney disease (17%), social (13%) or immunological reasons (7%). Read More

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http://dx.doi.org/10.1111/imj.14223DOI Listing

Differential Clinical Characteristics, Management, and Outcome of Delirium among Ward Compared with ICU Patients.

Intern Med J 2019 Mar 19. Epub 2019 Mar 19.

Department of Intensive Care, Austin Hospital, Heidelberg, Melbourne, Victoria, Australia.

Background: Delirium is common in hospitalized patients but its epidemiology remains poorly characterized.

Aims: To test the hypothesis that patient demographics, clinical phenotype, management, and outcomes of patient with delirium in hospital ward patients differ from ICU patients.

Methods: Retrospective cohort of patients admitted to an Australian university-affiliated hospital between March 2013 and April 2017 and coded for delirium at discharge using the ICD-10 criteria. Read More

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http://dx.doi.org/10.1111/imj.14287DOI Listing
March 2019
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What's new in lipid lowering therapies in diabetes?

Intern Med J 2019 Mar 19. Epub 2019 Mar 19.

Austin Health Endocrine Centre, Heidelberg, Victoria, Australia.

Diabetes can lead to myriad of microvascular and macrovascular complications - with the leading cause of mortality in diabetes being cardiovascular disease (CVD). Low-density lipoprotein cholesterol (LDL-C), along with non-high-density lipoprotein cholesterol (non-HDL-C) and triglycerides (TGs) are proven, modifiable risk factors for CVD. This article will focus on lipid lowering agents in individuals with diabetes. Read More

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http://dx.doi.org/10.1111/imj.14291DOI Listing
March 2019
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Discharge treatment with ACE inhibitor/ARB after a heart failure hospitalization is associated with a better prognosis irrespectively of left ventricular ejection fraction.

Intern Med J 2019 Mar 19. Epub 2019 Mar 19.

Cardiology Department, Hospital General Universitario Gregorio Marañón. CIBERCV. Madrid, Spain.

Background: Medical therapy could improve the prognosis of real-life patients discharged after a heart failure (HF) hospitalization. We aimed to determine the impact of discharge HF treatment on mortality and readmissions in different left ventricular ejection fraction (LVEF) groups.

Methods: Multicentre prospective registry in 20 Spanish hospitals. Read More

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http://dx.doi.org/10.1111/imj.14289DOI Listing

Time to acute stroke treatment in-hours was more than halved after the introduction of the Helsinki model at Westmead Hospital.

Intern Med J 2019 Mar 19. Epub 2019 Mar 19.

Westmead Hospital, Westmead, NSW.

Background: Management of acute ischaemic stroke is time critical. Reducing time to treatment with thrombolysis is strongly associated with improved outcomes in properly selected patients. However, there are barriers to ensuring timely treatment in the hospital setting. Read More

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http://dx.doi.org/10.1111/imj.14290DOI Listing

Utilisation of systemic therapy options in routine treatment of metastatic colorectal cancer in Australia.

Intern Med J 2019 Mar 18. Epub 2019 Mar 18.

Department of Medical Oncology, Eastern Health, Box Hill, Australia.

Background/aim: In the treatment of metastatic colorectal cancer (mCRC), exposure to all three active cytotoxic agents; 5-fluorouracil/capecitabine, irinotecan and oxaliplatin improves overall survival. The addition of biologic agents (bevacizumab and cetuximab/panitumumab) further improves survival. The uptake of available systemic agents for mCRC in routine practice in Australia is poorly described. Read More

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http://dx.doi.org/10.1111/imj.14288DOI Listing
March 2019
1 Read

Illicit drug use and acute kidney injury in patients admitted to hospital with rhabdomyolysis.

Intern Med J 2019 Feb 28. Epub 2019 Feb 28.

Department of General Medicine, Monash Health, Clayton, Victoria, 3168, Australia.

Background: Severe rhabdomyolysis is associated with acute kidney injury but it is unclear if patients developing rhabdomyolysis after illicit drug use have a higher risk of acute kidney injury compared to other causes.

Aims: To provide a descriptive analysis of patients admitted with rhabdomyolysis, with a focus on illicit drug use, and to determine if illicit drug use was an independent predictor for acute kidney injury or renal replacement therapy.

Methods: We conducted a 5-year cohort study of patients admitted to Monash Health, a tertiary referral hospital network. Read More

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http://dx.doi.org/10.1111/imj.14266DOI Listing
February 2019
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Characteristics, risk factors and management of venous thromboembolism in immune thrombocytopenia: a retrospective multicenter study.

Intern Med J 2019 Feb 28. Epub 2019 Feb 28.

Department of Internal Medicine, Reference center of autoimmune cytopenias, University Hospital Henri-Mondor, APHP, UPEC, Créteil, France.

Background: increased risk of thrombosis has been reported in immune thrombocytopenic purpura (ITP), but the characteristics, risk factors of occurrence, recurrence and management of venous thromboembolic events (VTEs) have been poorly investigated.

Aims: to describe VTE and ITP characteristics, distribution of VTE risk factors and their impact on VTE features and recurrence.

Methods: retrospective study of patients with ITP and VTE registered in databases of 3 reference French centers of ITP RESULTS: Among 49 patients, 66 VTEs were recorded. Read More

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http://dx.doi.org/10.1111/imj.14269DOI Listing
February 2019
3 Reads

Front-line management of indolent non-Hodgkin lymphoma in Australia. Part 2: mantle cell lymphoma and marginal zone lymphoma.

Intern Med J 2019 Feb 28. Epub 2019 Feb 28.

Division of Cancer Services, Clinical Haematology, Princess Alexandra Hospital, Brisbane, QLD.

Mantle cell lymphoma (MCL) and the marginal zone lymphoma (MZL) subtypes (nodal MZL, extra-nodal MZL of mucosa-associated lymphoid tissue (MALT lymphoma) and splenic MZL) are uncommon lymphoma subtypes, accounting for less than 5-10% of all non-Hodgkin lymphoma. The evidence base for therapy is therefore limited and enrolment into clinical trials is preferred. Outcomes for patients with MCL have been steadily improving mainly due to the adoption of more intense strategies in younger patients, the use of rituximab maintenance and the recent introduction of bendamustine in older patients. Read More

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http://dx.doi.org/10.1111/imj.14268DOI Listing
February 2019
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Under-detection of Acute Kidney Injury in Hospitalised Patients - A Retrospective, multi-site, longitudinal study.

Intern Med J 2019 Feb 28. Epub 2019 Feb 28.

Department of Nephrology, Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia.

Background: Acute kidney injury (AKI) is a rapid deterioration of renal function, often caused by a variety of co-existing morbidities complicating its recognition and treatment, leading to short- and long-term adverse clinical outcomes. There are limited data on the incidence of AKI in Australia using the Kidney Disease Improving Global Outcomes (KDIGO) creatinine-based consensus definition.

Aim: To determine the incidence and estimate the extent of under-reporting of AKI in four hospitals in the South-Eastern Sydney/Illawarra regions of New South Wales, Australia. Read More

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Source
http://doi.wiley.com/10.1111/imj.14264
Publisher Site
http://dx.doi.org/10.1111/imj.14264DOI Listing
February 2019
31 Reads