831,818 results match your criteria Internal medicine journal[Journal]


Functional Imaging of Visuospatial Attention in Complex and Naturalistic Conditions.

Curr Top Behav Neurosci 2018 Dec 15. Epub 2018 Dec 15.

Lyon Neuroscience Research Center, Bron, France.

One of the ultimate goals of cognitive neuroscience is to understand how the brain works in the real world. Functional imaging with naturalistic stimuli provides us with the opportunity to study the brain in situations similar to the everyday life. This includes the processing of complex stimuli that can trigger many types of signals related both to the physical characteristics of the external input and to the internal knowledge that we have about natural objects and environments. Read More

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December 2018

High Dose Prednisolone Lowers Plasma Glycated Albumin Levels Compared to Actual Glycemic Control: A Retrospective Observational Study.

Diabetes Ther 2018 Dec 13. Epub 2018 Dec 13.

Department of Diabetes and Endocrinology, Graduate School of Medicine, Gifu University, Gifu, 501-1194, Japan.

Introduction: Glycated hemoglobin (A1c) and glycated albumin (GA) are often used as indicators of glycemic control. In this study, we determined whether prednisolone (PSL) administration lowers plasma GA.

Methods: We investigated the factors affecting GA using multivariate analysis in 48 subjects with connective tissue diseases (CTDs). Read More

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December 2018
2 Reads

Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group.

J Clin Immunol 2018 Dec 13. Epub 2018 Dec 13.

Paediatric Immunology Unit, Department of Paediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. Read More

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December 2018
1 Read

Chromoblastomycosis Caused by Fonsecaea nubica: First Report in Northern China and Literature Review.

Mycopathologia 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatovenereology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wuhou District, Chengdu, 610041, Sichuan Province, China.

Chromoblastomycosis is found worldwide with higher incidence in tropical and subtropical regions. Fonsecaea spp. is one of the major causative agents of this disease. Read More

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December 2018

Insomnia and cardiorespiratory fitness in a middle-aged population: the SCAPIS pilot study.

Sleep Breath 2018 Dec 13. Epub 2018 Dec 13.

Center for Sleep and Vigilance Disorders, Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 8b, Box 421, SE-40530, Gothenburg, Sweden.

Background: The relationship between insomnia and cardiorespiratory fitness (CRF), a well-established risk factor for cardiovascular disease, has not been extensively studied. We aimed to assess the independent association between insomnia and CRF in a population-based cohort of subjects aged 50 to 64 years.

Methods: Subjects participating in the Swedish CArdioPulmonary bioImaging Study (SCAPIS) pilot cohort (n = 603, men 47. Read More

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December 2018

Health Care Facility Characteristics are Associated with Variation in Human Immunodeficiency Virus Pre-exposure Prophylaxis Initiation in Veteran's Health Administration.

AIDS Behav 2018 Dec 13. Epub 2018 Dec 13.

VA Puget Sound Health Care System, Health Services Research and Development, Seattle, WA, USA.

To quantify health care facility-level variation in pre-exposure prophylaxis (PrEP) use in the Veteran's Health Administration (VHA); to identify facility characteristics associated with PrEP use. Retrospective analysis of the health care facility-level rate of PrEP initiation in VHA through June 30, 2017. Standardized PrEP initiation rates were used to rank facilities. Read More

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December 2018

Traumatic occipitoatlantal dissociation: high index of suspicion should be kept in mind.

Intensive Care Med 2018 Dec 13. Epub 2018 Dec 13.

Emergency and Intensive Care Department, Hospital de Faro, Centro Hospitalar Universitário Do Algarve, Faro, Portugal.

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December 2018

Opening-wedge osteotomies of the distal femur: minor advantages for a biplanar compared to a uniplanar technique.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 13. Epub 2018 Dec 13.

Institute of Biomechanics, Paracelsus Medical University Salzburg, Strubergasse 21, 5020, Salzburg, Austria.

Purpose: Valgus malalignment of the distal femur may be treated with corrective osteotomy. The purpose of this study was to compare the primary stability of a lateral opening-wedge osteotomy (LOWO) using a uniplanar compared to a biplanar technique. A study was carried out to test both surgeries, with both an intact medial cortex and with a deliberate attached cut of the medial cortex simulating a fracture. Read More

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December 2018

Microparticulate P2X7 and GSDM-D mediated regulation of functional IL-1β release.

Purinergic Signal 2018 Dec 13. Epub 2018 Dec 13.

Department of Physiology and Cell Biology, The Ohio State University, 473 W 12th Avenue, Columbus, OH, 43210, USA.

The pro-inflammatory cytokine IL-1β is a secreted protein that is cleaved by caspase-1 during inflammasome activation upon recognition of internal and external insults to cells. Purinergic receptor P2X7 has been described to be involved in the release pathway of bioactive mature IL-1β by activated immune cells. Microparticle (MP) shedding has also been recently recognized as a manner of cytokine IL-1β release. Read More

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December 2018

Correction to: Impaired endogenous nighttime melatonin secretion relates to intrarenal renin-angiotensin system activation and renal damage in patients with chronic kidney disease.

Clin Exp Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Internal Medicine 1, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

In the original publication, an error occurred in Table 4 (B), under Nighttime group. The value of "Nighttime Log U-AGT/Cr" for model 3 (under R = 0.68) was incorrectly published as 0. Read More

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December 2018

Low-level laser therapy versus trunk stabilization exercises on sternotomy healing after coronary artery bypass grafting: a randomized clinical trial.

Lasers Med Sci 2018 Dec 13. Epub 2018 Dec 13.

Department of Physical Therapy for Internal Medicine, Faculty of Physical Therapy, Cairo University, Giza, Egypt.

The aim of this study was to investigate the effects of low-level laser therapy (LLLT) versus trunk stabilization exercises on sternotomy healing following coronary artery bypass grafting (CABG) surgery. Forty-five male patients who had acute sternal instability post-CABG surgery in the age range of 45-65 years were divided randomly into three equal groups (n = 15). The laser group received LLLT, while the exercise group received trunk stabilization exercises. Read More

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December 2018
2 Reads

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria.

Diabetologia 2018 Dec 13. Epub 2018 Dec 13.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aims/hypothesis: Identifying rare coding variants associated with albuminuria may open new avenues for preventing chronic kidney disease and end-stage renal disease, which are highly prevalent in individuals with diabetes. Efforts to identify genetic susceptibility variants for albuminuria have so far been limited, with the majority of studies focusing on common variants.

Methods: We performed an exome-wide association study to identify coding variants in a two-stage (discovery and replication) approach. Read More

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December 2018

A call for improved reporting of human islet characteristics in research articles.

Diabetologia 2018 Dec 14. Epub 2018 Dec 14.

Institute of Cellular Medicine, Faculty of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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December 2018

Hepatobiliary phase in cirrhotic patients with different Model for End-stage Liver Disease score: comparison of the performance of gadoxetic acid to gadobenate dimeglumine.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

ASST Grande Ospedale Metropolitano Niguarda, Piazza dell'Ospedale Maggiore, 3, 20162, Milan, Italy.

Objectives: The purpose of this study was to compare the performance of gadobenate dimeglumine-enhanced MRI and gadoxetic acid-enhanced MRI in the hepatobiliary phase (HBP) in cirrhotic patients with different degrees of liver dysfunction.

Methods: In this retrospective cross-sectional study, we analyzed the unenhanced phase and the HBP of 131 gadobenate dimeglumine-enhanced MRI examinations (gadobenate dimeglumine group) and 127 gadoxetic acid-enhanced MRI examinations (gadoxetic acid group) performed in 249 cirrhotic patients (181 men and 68 women; mean age, 64.8 years) from August 2011 to April 2017. Read More

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December 2018

Comparison of lung imaging using three-dimensional ultrashort echo time and zero echo time sequences: preliminary study.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea.

Objective: To determine the feasibility of using high-resolution volumetric zero echo time (ZTE) sequence in routine lung magnetic resonance imaging (MRI) and compare free breathing 3D ultrashort echo time (UTE) and ZTE lung MRI in terms of image quality and small-nodule detection.

Materials And Methods: Our Institutional Review Board approved this study. Twenty patients underwent both UTE and ZTE sequences during routine lung MR. Read More

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December 2018

Prognosis-based definition of left ventricular remodeling after ST-elevation myocardial infarction.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria.

Objectives: Cardiac magnetic resonance (CMR) is the gold-standard modality for the assessment of left ventricular (LV) remodeling in ST-elevation myocardial infarction (STEMI) patients. However, the commonly used remodeling criteria have never been validated for hard clinical events. We therefore aimed to define clear CMR criteria of LV remodeling following STEMI with proven prognostic impact. Read More

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December 2018

Modifiable Risk-factors for Keratinocyte Cancers in Australia: A Case-control Study.

Acta Derm Venereol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Epidemiology and Applied Biostatistics, University Hospital Tübingen, DE-72076 Tübingen, Germany.

Keratinocyte cancer (KC) is the most common malignancy in Caucasians. The incidence of KC has increased over the past 40 years. This case-control study investigated the environmental and host risk-factors responsible for development of KC in Australia's high-risk population. Read More

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December 2018

Customized endovascular repair of common iliac artery aneurysms.

J Vasc Surg Cases Innov Tech 2018 Dec 4;4(4):278-282. Epub 2018 Dec 4.

Division of Vascular Surgery, Inova Fairfax Hospital, Falls Church, Va.

Open technique for elective repair of iliac artery aneurysms can be safely performed with good outcomes but not inconsequential morbidity. An endovascular approach has been shown to have both periprocedural and postoperative advantages with equivalent outcomes. Endovascular repair of common iliac arteries (CIAs) without sacrificing the hypogastric artery using an iliac branch device is a complex endovascular technique requiring a proximal seal zone that may be absent in larger CIA aneurysms. Read More

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December 2018

Takotsubo syndrome in a stroke patient with carotid artery stenosis.

eNeurologicalSci 2018 Dec 22;13:46-48. Epub 2018 Nov 22.

Krankenanstalt Rudolfstiftung, Juchgasse 25, A-1030 Wien, Austria.

Takotsubo syndrome (TTS) is a transient transient left ventricular dysfunction, predominantly affecting elderly women and often preceded by emotional or physical stress. TTS may be the cause as well as the consequence of stroke. We report a 82-years old female with a history of long-standing untreated arterial hypertension who was hospitalized because of a left-sided tongue paralysis and dysarthria. Read More

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December 2018

Biochemical Characterization of AroH, a Putative Aromatic Amino Acid Aminotransferase.

Front Mol Biosci 2018 28;5:104. Epub 2018 Nov 28.

Department of Experimental Medicine, University of Perugia, Perugia, Italy.

The rise in the frequency of nosocomial infections is becoming a major problem for public health, in particular in immunocompromised patients. is an opportunistic fungus normally present in the environment directly responsible for lethal invasive infections. Recent results suggest that the metabolic pathways related to amino acid metabolism can regulate the fungus-host interaction and that an important role is played by enzymes involved in the catabolism of L-tryptophan. Read More

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November 2018

Durian Fruits Discovered as Superior Folate Sources.

Front Nutr 2018 28;5:114. Epub 2018 Nov 28.

Chair of Analytical Food Chemistry, Technical University of Munich, Freising, Germany.

Durian () is a tropical fruit grown in Southeast Asia and highly appreciated by consumers throughout Asia. Folates are a group of vitamins and are essential nutrients for humans. Here we present the folate analysis of different durian cultivars as well as diverse durian products. Read More

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November 2018

Co-existing Bilateral Pulmonary Embolism and Intra-cardiac Mass: A Case of Catastrophic Antiphospholipid Syndrome-like Disease.

Cureus 2018 Oct 10;10(10):e3438. Epub 2018 Oct 10.

Internal Medicine, Shifa International Hospital, Islamabad, PAK.

Young patients presenting with thrombotic events like pulmonary embolism and cardiological phenomenon such as presence of an intracardiac mass, without any underlying risk factors, should be promptly investigated for thrombophilias including antiphospholipid syndrome (APLS). This case is reported to highlight rare occurrence of co-existing bilateral extensive pulmonary embolism and an intra-cardiac mass at presentation of antiphospholipid syndrome as well as progression to near catastrophic APLS. Read More

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October 2018

Optimal Scene Time to Achieve Favorable Outcomes in Out-of-hospital Cardiac Arrest: How Long Is Too Long?

Cureus 2018 Oct 9;10(10):e3434. Epub 2018 Oct 9.

Internal Medicine, Brookdale University Hospital Medical Center, New York, USA.

Background Despite advances in resuscitation science and public health, out-of-hospital cardiac arrest (OOHCA) cases have an average survival rate of only 12% nationwide, compared to 24.8% of cases occurring in hospital. Many factors, including resuscitation interventions, contribute to positive patient outcomes and have, therefore, been studied in attempts to optimize emergency medical services (EMS) protocols to achieve higher rates of return of spontaneous circulation (ROSC) in the field. Read More

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October 2018

The Life and Work of Nikolai Ivanovich Pirogov (1810-1881): An Outstanding Anatomist and Surgeon.

Cureus 2018 Oct 8;10(10):e3424. Epub 2018 Oct 8.

Otolaryngology, Aristotle University of Thessaloniki, Thessalonki, GRC.

Nikolai Ivanovich Pirogov is considered one of the most important anatomists and surgeons in the history of medicine. The Russian physician conducted more than 11,000 dissections and meticulously studied human anatomy, discovering important anatomical regions such as Pirogov's triangle. Pirogov developed surgical methods and techniques used by physicians for many decades such as Pirogov's amputation. Read More

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October 2018

Relationship Between Thyroid Hormone Levels and Mean Platelet Count and Volume: Quantitative Assessment.

Cureus 2018 Oct 8;10(10):e3421. Epub 2018 Oct 8.

Internal Medicine, Virginia Commonwealth University, Richmond, USA.

Background The hormones of the hypophysis-thyroid axis (HTA), thyroid stimulating hormone (TSH), and thyroid hormones, L-thyroxine (T4) and 3, 3', 5-L-triiodothyronine (T3), modulate the metabolism, differentiation, and proliferation of almost every cell in the body. Several studies have examined the effect of HTA hormones on platelet count and mean platelet volume (MPV), but have reported inconsistent results. Our aim was to examine the association between HTA hormones and platelet count and MPV in a large cohort of the adult population of the United States. Read More

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October 2018

An AI-Based Heart Failure Treatment Adviser System.

IEEE J Transl Eng Health Med 2018 23;6:2800810. Epub 2018 Nov 23.

Computer Science DepartmentThe University of Texas at DallasRichardsonTX75080USA.

Management of heart failure is a major health care challenge. Healthcare providers are expected to use best practices described in clinical practice guidelines, which typically consist of a long series of complex rules. For heart failure management, the relevant guidelines are nearly 80 pages long. Read More

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November 2018

Inhibition of MEK with trametinib enhances the efficacy of anti-PD-L1 inhibitor by regulating anti-tumor immunity in head and neck squamous cell carcinoma.

Oncoimmunology 2019 21;8(1):e1515057. Epub 2018 Sep 21.

Cancer Research Institute, Seoul National University, Seoul, Korea.

Major histocompatibility complex (MHC) class I downregulation is the primary immune evasion mechanism associated with failure in anti-PD-1/PD-L1 blockade therapies for cancer. Here, we examined the role of MEK signaling pathway inhibition in head and neck squamous cell carcinoma (HNSCC) both and . We found that trametinib, a small molecule inhibitor of MEK, significantly enhanced MHC class I and PD-L1 expression in human HNSCC cell lines, and this occurred via STAT3 activation. Read More

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September 2018

B cells in esophago-gastric adenocarcinoma are highly differentiated, organize in tertiary lymphoid structures and produce tumor-specific antibodies.

Oncoimmunology 2019 2;8(1):e1512458. Epub 2018 Nov 2.

German Cancer Consortium (DKTK), Heidelberg, Germany.

Tumor-infiltrating lymphocytes (TILs) are correlated to prognosis of several kinds of cancer. Most studies focused on T cells, while the role of tumor-associated B cells (TABs) has only recently gained more attention. TABs contain subpopulations with distinct functions, potentially promoting or inhibiting immune responses. Read More

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November 2018

Bone marrow endothelial cells sustain a tumor-specific CD8 T cell subset with suppressive function in myeloma patients.

Oncoimmunology 2019 22;8(1):e1486949. Epub 2018 Oct 22.

Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine "Guido Baccelli", University of Bari Medical School, Bari, Italy.

Endothelial cells (EC) line the bone marrow microvasculature and are in close contact with CD8 T cells that come and go across the permeable capillaries. Because of these intimate interactions, we investigated the capacity of EC to act as antigen-presenting cells (APC) and modulate CD8 T cell activation and proliferation in bone marrow of patients with multiple myeloma (MM) and monoclonal gammopathy of undetermined significance. We found that EC from MM patients show a phenotype of semi-professional APC given that they express low levels of the co-stimulatory molecules CD40, CD80 and CD86, and of the inducible co-stimulator ligand (ICOSL). Read More

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October 2018

mutation and DNA repair and synthesis genes in non-small-cell lung cancer.

Mol Clin Oncol 2018 Dec 1;9(6):689-696. Epub 2018 Oct 1.

Department of Medical Oncology, Santa Maria della Misericordia Hospital, AOU di Perugia, I-06129 Perugia, Italy.

The aim of the present study was to assess the expression of select DNA repair and synthesis genes in non-small-cell lung cancer (NSCLC) according to mutation status. ERCC1, TS, RRM1, and BRCA1 mRNA expression levels were assessed from either primary or metastatic tumor specimens of patients diagnosed with epidermal growth factor receptor () wild-type (WT) advanced NSCLC. Total RNA was isolated from paraffin-embedded tumor specimens using the RNeasy FFPE kit and automatically purified using a QiaCube instrument. Read More

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December 2018

Miliary lung metastases from non-small cell lung cancer with Exon 20 insertion: A dismal prognostic entity: A case report.

Mol Clin Oncol 2018 Dec 1;9(6):673-676. Epub 2018 Oct 1.

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Kanagawa 236-0051, Japan.

Miliary lung metastases have been reported to be frequently observed in nοn-small cell lung cancer (NSCLC) with major EGFR mutations, which consist of exon 19 deletion and exon 21 L858R. However, it remains undetermined whether NSCLC with minor EGFR mutations possesses characteristics similar to those with major EGFR mutations. In the present study, two cases of miliary lung metastases from NSCLC with exon 20 insertion were reported. Read More

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December 2018

Inhibition of osteoblast differentiation by ritonavir.

Biomed Rep 2018 Dec 2;9(6):491-496. Epub 2018 Oct 2.

Department of Internal Medicine, Teikyo University, Tokyo 173-8606, Japan.

Osteoporosis is one of the chronic complications seen in human immunodeficiency virus (HIV)-infected patients, and affects patients at high prevalence. The causes of osteoporosis in HIV-infected patients are multiple, and include chronic HIV infection, living habits such as smoking and alcohol consumption, and antiretroviral drug use. Among antiretroviral drugs, protease inhibitors have been reported to be associated with osteoporosis. Read More

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December 2018

The application of updating PIM-Taiwan criteria in clinic-visiting older patients with polypharmacy.

Ther Adv Drug Saf 2018 Dec 15;9(12):699-709. Epub 2018 Oct 15.

Department of Geriatrics and Gerontology, National Taiwan University Hospital, Zhongshan South Road, Zhongzheng District, Taipei, 100, Taiwan.

Background: PIM-Taiwan criteria were first established in 2010 for potentially inappropriate medications (PIMs). Currently, updating of PIM criteria is mandatory because of newly established evidence and newly developed medications. This study aims to evaluate the prevalence of PIM based on country-specific PIM criteria and factors associated with PIM use by applying 2010 version and newly updating PIM-Taiwan criteria in a cohort with polypharmacy. Read More

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December 2018

Common mental disorder among family carers of demented older people in Brazil.

Dement Neuropsychol 2018 Oct-Dec;12(4):402-407

MD,PhD, Department of Internal Medicine, São Paulo State University (UNESP), Botucatu Medical School, Botucatu, SP, Brazil.

Objective: Population aging is a global phenomenon associated with a rising prevalence of chronic degenerative diseases such as dementia. Dementia poses a challenge not only for patients but also their family caregivers who, in exercising this role, are at higher risk of mental illness. The present study investigated the prevalence of common mental disorders (CMD) in family caregivers of demented elderly seen at a geriatric outpatient clinic of a Brazilian teaching hospital. Read More

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December 2018

The Mini-Addenbrooke's Cognitive Examination (M-ACE) as a brief cognitive screening instrument in Mild Cognitive Impairment and mild Alzheimer's disease.

Dement Neuropsychol 2018 Oct-Dec;12(4):368-373

Grupo de Neurologia Cognitiva e do Comportamento (GNCC), Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

The Mini-Addenbrooke's Cognitive Examination (M-ACE) is a brief cognitive screening test that evaluates four main cognitive domains (orientation, memory, language and visuospatial function) with a maximum score of 30 points and administration time of five minutes.

Objective: To assess the performance of healthy elderly, MCI patients and mild AD patients using the Brazilian version of the M-ACE.

Methods: The test was applied to a group of 36 Mild Cognitive Impairment (MCI), 23 mild Alzheimer's Disease (AD) and 25 cognitive healthy elderly. Read More

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December 2018

The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension.

Oncotarget 2018 Nov 16;9(90):36220-36237. Epub 2018 Nov 16.

Department of Internal Medicine I, University of Bonn, Bonn, Germany.

Background And Aims: Angiogenesis is critically involved in the development of liver fibrosis, portal hypertension (PHT) and hepatocellular carcinoma (HCC). Regorafenib is a novel second-line therapy for HCC, but might also be beneficial in fibrosis and PHT even in absence of HCC. This study investigated the effects of regorafenib in experimental models without HCC. Read More

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November 2018

Anticancer activity of 2'-hydroxyflavanone towards lung cancer.

Oncotarget 2018 Nov 16;9(90):36202-36219. Epub 2018 Nov 16.

Division of Hematology and Oncology, Department of Internal Medicine, Texas Tech Health Sciences Center, Lubbock, TX 79430, USA.

In previous studies, we found that 2'-hydroxyflavonone (2HF), a citrus flavonoid, inhibits the growth of renal cell carcinoma in a VHL-dependent manner. This was associated with the inhibition of glutathione S-transferases (GSTs), the first step enzyme of the mercapturic acid pathway that catalyzes formation of glutathione-electrophile conjugates (GS-E). We studied 2HF in small cell (SCLC) and non-small cell (NSCLC) lung cancer cell lines for sensitivity to 2HF antineoplastic activity and to determine the role of the GS-E transporter Rlip (Ral-interacting protein; RLIP76; RALBP1) in the mechanism of action of 2HF. Read More

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November 2018
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Validity and reliability of the Japanese version of the Rathus assertiveness schedule in day psychiatric care users with schizophrenia.

J Rural Med 2018 Nov 29;13(2):172-176. Epub 2018 Nov 29.

International University of Health and Welfare Graduate School, Japan.

This study aimed to investigate the validity and reliability of the Japanese version of the Rathus assertiveness schedule (J-RAS) in psychiatric day care users with schizophrenia. We examined 715 psychiatric day care users with schizophrenia by conducting the test twice between September 2007 and February 2008 using a questionnaire-based survey. We examined construct validity and used the internal reliability test, split-half method, and test-retest method to examine reliability. Read More

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November 2018

Optimizing medical care for geriatric patients in Austria: defining a top five list of "Choosing Wisely" recommendations using the Delphi technique.

Eur Geriatr Med 2018 27;9(6):783-793. Epub 2018 Sep 27.

14Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.

Purpose: Inappropriate use of diagnostic and therapeutic medical procedures is common and potentially harmful for older patients. The Austrian Society of Geriatrics and Gerontology defined a consensus of five recommendations to avoid overuse of medical interventions and to improve care of geriatric patients.

Methods: From an initial pool of 147 reliable recommendations, 20 were chosen by a structured selection process for inclusion in a Delphi process to define a list of five top recommendations for geriatric medicine. Read More

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September 2018

1,8-Bis(dimethylamino)naphthyl-2-ketimines: Inside vs outside protonation.

Beilstein J Org Chem 2018 28;14:2940-2948. Epub 2018 Nov 28.

Institute of Chemistry, St. Petersburg State University, Universitetskii pr. 26, 198504 St. Petersburg, Russian Federation.

The structure and protonation behaviour of four -arylketimines of 1,8-bis(dimethylamonio)naphthalene with a different number of methoxy groups in an aromatic substituent were investigated in solution by NMR (acetone, DMSO, MeCN), in solid state by X-ray analysis and in the gas phase by DFT calculations. Both mono- and diprotonated species were considered. It has been shown that -isomers of neutral imines can be stabilised by an intramolecular C=N-H···OMe hydrogen bond with a neighbouring methoxy group. Read More

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November 2018

Effects of aspirin combined with cilostazol on thromboangiitis obliterans in diabetic patients.

Exp Ther Med 2018 Dec 8;16(6):5041-5046. Epub 2018 Oct 8.

Department of Blood Transfusion, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.

The present study explored the effects of aspirin combined with cilostazolin in the treatment of diabetic patients with thromboangiitis obliterans and the effects on the related inflammatory factors. A total of 90 diabetic patients with thromboangiitis obliterans admitted to Weifang People's Hospital from August 2015 to June 2017 were selected and divided into the control group (n=45) and the combination group (n=45). Patients in the control group were given aspirin, and those in the combination group were given aspirin combined with cilostazol. Read More

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December 2018

Functional changes of airway epithelial cells and mitochondria in rat models of asthenic lung and phlegm blocking combined with cough variant asthma.

Exp Ther Med 2018 Dec 15;16(6):5021-5024. Epub 2018 Oct 15.

Pneumology Department, The Affiliated Traditional Medical Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000, P.R. China.

The aim of this study was to investigated the functional changes of airway epithelial cells and mitochondria in rat models of asthenic lung and phlegm blocking combined with cough variant asthma (CVA). Sixteen Sprague-Dawley rats were randomly divided into two groups: Control and model group, with 8 rats in each group. On the basis of the CVA rat model induced and sensitized by ovalbumin and aluminum hydroxide, the rat models with asthenic lung and phlegm blocking combined with CVA were established via smoking stimulation. Read More

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December 2018

Imbalance of M1/M2 macrophages is linked to severity level of knee osteoarthritis.

Exp Ther Med 2018 Dec 11;16(6):5009-5014. Epub 2018 Oct 11.

Department of Emergency Surgery, The Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao, Shandong 266001, P.R. China.

Macrophages, whether M1 or M2 subtype, have been found to be implicated in the pathogenesis of osteoarthritis (OA). However, no study regarding the status of M1 and M2 macrophages has been reported in knee OA. To investigate the status of M1 and M2 macrophages in knee OA, synovial fluid as well as peripheral blood were collected from 80 patients with knee OA and 80 healthy controls. Read More

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December 2018

Activation of astrocytes and expression of inflammatory cytokines in rats with experimental autoimmune encephalomyelitis.

Exp Ther Med 2018 Dec 27;16(6):4401-4406. Epub 2018 Sep 27.

Department of Neurology, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252601, P.R. China.

The aim of the study was to investigate and discuss the activation of astrocytes and the expression of inflammatory cytokines in rats with experimental autoimmune encephalomyelitis (EAE). Twenty Wistar rats were randomly divided into the normal control (n=10) and EAE group (n=10). The rats in the EAE group were injected intraperitoneally with myelin oligodendrocyte glycoprotein 35-55 emulsion, and those in the control group were injected with the equivalent volume of normal saline. Read More

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December 2018

Conservation and Diversification of Circadian Rhythmicity Between a Model Crassulacean Acid Metabolism Plant and a Model C Photosynthesis Plant .

Front Plant Sci 2018 28;9:1757. Epub 2018 Nov 28.

Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States.

Crassulacean acid metabolism (CAM) improves photosynthetic efficiency under limited water availability relative to C photosynthesis. It is widely accepted that CAM plants have evolved from C plants and it is hypothesized that CAM is under the control of the internal circadian clock. However, the role that the circadian clock plays in the evolution of CAM is not well understood. Read More

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November 2018

Neutrophil Mechanosignaling Promotes Integrin Engagement With Endothelial Cells and Motility Within Inflamed Vessels.

Front Immunol 2018 28;9:2774. Epub 2018 Nov 28.

Simon Lab, Department of Biomedical Engineering, University of California, Davis, Davis, CA, United States.

Neutrophils are the most motile of mammalian cells, a feature that enables them to protect the host against the rapid spread of pathogens from tissue into the circulatory system. A critical process is the recruitment of neutrophils to inflamed endothelium within post-capillary venules. This occurs through cooperation between at least four families of adhesion molecules and G-protein coupled signaling receptors. Read More

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November 2018

Increased Excitability Induced in the Primary Motor Cortex by Transcranial Ultrasound Stimulation.

Front Neurol 2018 28;9:1007. Epub 2018 Nov 28.

Psychology Clinical Neuroscience Center, Department of Psychology, University of New Mexico, Albuquerque, NM, United States.

Transcranial Ultrasound Stimulation (tUS) is an emerging technique that uses ultrasonic waves to noninvasively modulate brain activity. As with other forms of non-invasive brain stimulation (NIBS), tUS may be useful for altering cortical excitability and neuroplasticity for a variety of research and clinical applications. The effects of tUS on cortical excitability are still unclear, and further complications arise from the wide parameter space offered by various types of devices, transducer arrangements, and stimulation protocols. Read More

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November 2018

Clinical Efficacy of a Novel Therapeutic Principle, Anakoinosis.

Front Pharmacol 2018 28;9:1357. Epub 2018 Nov 28.

Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.

Classic tumor therapy, consisting of cytotoxic agents and/or targeted therapy, has not overcome therapeutic limitations like poor risk genetic parameters, genetic heterogeneity at different metastatic sites or the problem of undruggable targets. Here we summarize data and trials principally following a completely different treatment concept tackling systems biologic processes: the principle of communicative reprogramming of tumor tissues, i.e. Read More

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November 2018

The Hippocampal Engram as a Memory Index.

J Exp Neurosci 2018 2;12:1179069518815942. Epub 2018 Dec 2.

Laboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wako, Japan.

The hippocampus encodes memories for past events, but the nature of the hippocampal code subserving this function remains unclear. A prevailing idea, strongly supported by hippocampal physiology, is the Cognitive Map Theory. In this view, episodic memories are anchored to spatial domains, or allocentric frameworks, of experiences, with the hippocampus providing a stable representation of external space. Read More

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December 2018
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Single-stage reconstruction of large defect of oral commissure and lips by submental artery island flap.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):222-224

Department of Gynaecology and Obstetrics, Apollo Institute of Medical Sciences, Hyderabad, Telangana, India.

Large defect of the lip and buccal mucosa created due to wide resection of the cancer is difficult to reconstruct and always a challenge. Such defects are complex as there is loss of outer skin, muscle, soft tissue, and inner mucosal lining. We report the use of submental artery island flap (SAIF) in the reconstruction of a large defect of oral commissure and buccal mucosa in a 70-year-old female with the diagnosis of verrucous carcinoma. Read More

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December 2018
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