81,962 results match your criteria Interdisciplinary Perspectives on Infectious Diseases [Journal]
Domest Anim Endocrinol 2018 Nov 3;67:1-10. Epub 2018 Nov 3.
Department of Morphology and Function, CIISA- Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Prostaglandin E (PGE) has contradictory effects in many organs. It may have proinflammatory, anti-inflammatory, or anti-fibrotic roles, depending on the type of receptors to which it binds. By signaling through its receptors EP2 and EP4, PGE mediates anti-inflammatory and anti-fibrotic actions. Read More
Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.
Department of Animal Biotechnology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand 388110, Gujarat, India.
Members of the genus Aspergillus are extensively studied ascomycetes because of their ability to synthesize high value-added compounds and enzymes of industrial interest. Precise whole genome assembly and gene annotation are significant for gene functional analyses. Here, we report the draft genome sequencing, assembly and whole genome analysis of Aspergillus terreus P14_T3, isolated from rumen sample of cattle fed with coconut-coir. Read More
J Invertebr Pathol 2018 Dec 3. Epub 2018 Dec 3.
Laboratory of Animal Pathology, Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal; University Institute of Health Sciences & Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central da Gandra no. 1317, 4585-116 Gandra, Portugal.
Three new types of sphaeractinomyxon (Cnidaria, Myxozoa) are described from the coelomic cavity of the marine oligochaete Tubificoides insularis, collected from the Alvor estuary, Algarve, Portugal. Another known type is also registered from this location and host: Sphaeractinomyxon type 10 of Rangel et al., 2016, which was originally described from the marine oligochaete Tubificoides pseudogaster in the Aveiro estuary, Portugal. Read More
Interact Cardiovasc Thorac Surg 2018 Dec 5. Epub 2018 Dec 5.
Department of Cardiovascular Surgery, University Hospital of Bern, Bern, Switzerland.
Curr Opin Anaesthesiol 2018 Dec 4. Epub 2018 Dec 4.
Department of Anesthesiology and Pain Medicine, Ludwig-Maximilians University Munich.
Purpose Of Review: Chronic noncancer pain is an increasing problem in elderly because of rising life expectancy together with an increase of potentially painful medical conditions. Concomitantly, adequate treatment of elderly is often limited by coexisting diseases and polypharmacy.This review summarizes the most important specifics presented by elderly patients and discusses the pharmacological and nonpharmacological options of pain management. Read More
Elife 2018 Dec 6;7. Epub 2018 Dec 6.
Department of Bioagricultural Sciences and Pest Management, Colorado State University, Fort Collins, United States.
Interdisciplinary syntheses are needed to scale up discovery of the environmental drivers and molecular basis of adaptation in nature. Here we integrated novel approaches using whole genome sequences, satellite remote sensing, and transgenic experiments to study natural loss-of-function alleles associated with drought histories in wild . The genes we identified exhibit population genetic signatures of parallel molecular evolution, selection for loss-of-function, and shared associations with flowering time phenotypes in directions consistent with longstanding adaptive hypotheses 7 times more often than expected by chance. Read More
J Dtsch Dermatol Ges 2018 Dec 6. Epub 2018 Dec 6.
Department of Dermatology, Venereology, and Allergology, University Medical Centre, Göttingen, Germany.
Pityriasis rubra pilaris (PRP) is a rare papulosquamous disorder. Treatment is challenging; the armamentarium consists of topical corticosteroids, phototherapy, classic systemic treatments such as retinoids or immunosuppressive drugs, and most recently biologicals. However, the relative effectiveness of therapies is unclear. Read More
Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.
University of Groningen, University Medical Center Groningen, Department of Dermatology, The Netherlands.
Background: Analyses of the European Surveillance System on Contact Allergies (ESSCA) database have focused primarily on prevalence of contact allergies to the European baseline series; overall and in subgroups of patients. However, affected body sites have hitherto not been addressed.
Objective: To determine prevalence of contact allergies for distinct body sites in patients with allergic contact dermatitis (ACD). Read More
Forensic Sci Med Pathol 2018 Dec 5. Epub 2018 Dec 5.
Department of Biological Sciences, Florida International University, Miami, FL, USA.
Death does not occur instantaneously and organs do not decompose at the same rate or in the same way. Nulligravid human uteri and prostate glands are the last internal organs to deteriorate during decomposition; however, the reason for this very important observation is still enigmatic. Recent studies have elucidated that the composition and abundance of microbes in the human thanatomicrobiome (microbiome of death) varies by organ and changes as a function of time and temperature. Read More
Aging Clin Exp Res 2018 Dec 5. Epub 2018 Dec 5.
Institute of Public Health and Clinical Nutrition, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Purpose: Medication-related problems and declined functional capacity are closely associated factors among older people. The purpose of this study is to describe the procedure of interprofessional medication assessment in home care context and the baseline characteristics of the study population.
Methods: The FIMA study was a randomized, controlled intervention study comparing general practitioner-led interprofessional medication assessment and usual care. Read More
Demography 2018 Nov 12. Epub 2018 Nov 12.
Max Planck Institute for Demographic Research, Rostock, Germany.
Central and Eastern Europe (CEE) have experienced considerable instability in mortality since the 1960s. Long periods of stagnating life expectancy were followed by rapid increases in life expectancy and, in some cases, even more rapid declines, before more recent periods of improvement. These trends have been well documented, but to date, no study has comprehensively explored trends in lifespan variation. Read More
Ann Hematol 2018 Dec 5. Epub 2018 Dec 5.
Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124, Bari, Italy.
Hematopoietic stem cell transplantation (HSCT) recipients have been reported to have an increased risk of chronic graft versus host disease (cGVHD) and hematological and solid cancers. Oral manifestations are the first signs of cGVHD observed in the majority of patients, and oropharyngeal cancer is the most frequent secondary malignancy occurred after HSCT. In this study, we have evaluated the inflammatory infiltrate cell content and correlated with the vascular density in patients affected by primary oral squamous cell carcinoma (OSCC) from previous healthy controls and OSCC after cGVHD. Read More
J Rehabil Med 2018 Dec 4. Epub 2018 Dec 4.
Research Group Lifestyle and Health, University of Applied Sciences Utrecht, 3584 CS Utrecht, The Netherlands.
Objective: Systematic review to identify predictors for dropout during interdisciplinary pain management programmes.
Data Sources: PubMed, PsycINFO, CINAHL, Embase, and SPORTDiscus were searched from inception to 22 June 2017.
Study Selection: Screening, data-extraction and quality assessment was carried out independently by 2 researchers. Read More
Ecol Evol 2018 Nov 25;8(22):10834-10846. Epub 2018 Oct 25.
Institute of Interdisciplinary Mountain Research, IGF Austrian Academy of Sciences Innsbruck Austria.
Carabids are abundant in temperate agroecosystems and play a pivotal role as biocontrol agents for weed seed and pest regulation. While there is good knowledge regarding their effects on invertebrate pests, direct evidence for seed predation in the field is missing. Molecular approaches are ideally suited to investigate these feeding interactions; however, the effects of an omnivorous diet, which is characteristic for many carabid species, and seed identity on the detection success of seed DNA has not yet been investigated. Read More
Int J Disaster Resil Built Environ 2018 ;9(4-5):402-419
Department of Landscape Architecture and Urban Planning, Texas A&M University, College Station, TX.
Purpose: Participatory action research can improve scientific knowledge and community capacity to address disaster resilience and environmental justice. Evidence from the literature suggests that resident participation enhances assessment of environmental risks, raises awareness, and empowers residents to fight for equitable distribution of hazard and climate risk adaptations. Yet, risk assessment and urban planning processes still frequently operate within expertise-driven groups without significant community engagement. Read More
Front Psychol 2018 21;9:2238. Epub 2018 Nov 21.
Department of Management and Organization, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Personal branding has become an important concept in management literature in recent years. Yet, with more than 100 scholarly papers published on the concept to date, it has developed into a fragmented area of research with a diversity of definitions and conceptual boundaries. This paper posits that this heterogeneity of extant research impedes theoretical and empirical advancement. Read More
Front Psychol 2018 16;9:2224. Epub 2018 Nov 16.
School of Information Studies and Centre for Interdisciplinary Research in Music Media and Technology, McGill University, Montreal, QC, Canada.
Soundscapes affect people's health and well-being and contribute to the perception of environments as restorative. This paper continues the validation process of a previously developed Perceived Restorativeness Soundscape Scale (PRSS). The study takes a novel methodological approach to explore the PRSS face and construct validity by examining the qualitative reasons for participants' numerical responses to the PRSS items. Read More
Front Aging Neurosci 2018 30;10:347. Epub 2018 Oct 30.
Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom.
Lewy body dementia (LBD) and Alzheimer's disease (AD) are common forms of dementia that have different clinical profiles but are both commonly associated with attentional deficits. The aim of this study was to investigate efficiency of different attentional systems in LBD and AD and its association with brain structural abnormalities. We studied reaction time (RT) data from 45 LBD, 31 AD patients and 22 healthy controls (HCs) using the Attention Network Test (ANT) to assess the efficiency of three different attentional systems: alerting, orienting and executive conflict. Read More
Clin Cosmet Investig Dent 2018 9;10:251-262. Epub 2018 Nov 9.
Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin 12247, Germany.
Background: The immune and bone systems are closely linked via cytokine cross-talk. This interdisciplinary field of research is referred to as osteoimmunology and pertains to inflammatory and osteoarticular diseases that feature the primary expression of tumor necrosis factor-alpha (TNF-α) and IL-6.
Objective: Are there bone resorptive processes wherein chronic inflammatory conditions are not linked to TNF-α and IL-6 expression, but rather to the expression of other cytokines?
Materials And Methods: A comprehensive literature search was performed in PubMed Central. Read More
Clin Interv Aging 2018 8;13:2289-2294. Epub 2018 Nov 8.
Department of Geriatric Medicine, Centre for Applied Nursing Research, Western Sydney University and Ingham Institute of Applied Medical Research, Aged Care Research Unit, Liverpool Hospital, Liverpool BC, NSW 1871, Australia.
Purpose: Ineffective interdisciplinary communication is linked to many adverse consequences of hospitalization. This study evaluated the effect of SIBR, a model of care that encourages interdisciplinary communication and patient and family participations, on in-hospital deaths and new nursing home (NH) placements.
Materials And Methods: This before-after study included 3,673 consecutive inpatients of mean age 83. Read More
Patient Prefer Adherence 2018 8;12:2291-2308. Epub 2018 Nov 8.
Department of Medical Psychology, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.
Purpose: To develop valid quality indicators (QIs) for physiotherapy care based on best available evidence, and to use these QIs to explore trends in the quality of physiotherapy care of patients with Whiplash-associated disorders (WAD) using guideline-based routinely collected data (RCD) gathered between 1996 and 2011.
Materials And Methods: The study consisted of two phases: 1) development of QIs and 2) analysis of patient records. A set of QIs was developed based on recommendations in the scientific literature and the Dutch Clinical Practice Guideline (CPG) "Physiotherapy Management and WAD". Read More
Bone Marrow Transplant 2018 Dec 5. Epub 2018 Dec 5.
Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.
This study investigated the prognostic factors in patients (n = 89) who experienced relapse and received chemotherapy plus donor leukocyte infusion (Chemo-DLI) after haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Patients with early relapse (< 6 vs. > 6 months after haplo-HSCT), higher bone marrow blast count before chemo-DLI (> 20% vs. Read More
Oncogene 2018 Dec 5. Epub 2018 Dec 5.
Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Obesity is a risk factor for breast cancer and also predicts poor clinical outcomes regardless of menopausal status. Contributing to the poor clinical outcomes is the suboptimal efficacy of standard therapies due to dose limiting toxicities and obesity-related complications, highlighting the need to develop novel therapeutic approaches for treating obese patients. We recently found that obesity leads to an increase in tumor-infiltrating macrophages with activated NLRC4 inflammasome and increased interleukin (IL)-1β production. Read More
Nat Rev Gastroenterol Hepatol 2018 Dec 5. Epub 2018 Dec 5.
Department of Interdisciplinary Medicine, Aldo Moro University of Bari, Bari, Italy.
Alterations of hepatic metabolism are critical to the development of liver disease. The peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on a transcriptional level, different aspects of liver metabolism, such as mitochondrial oxidative phosphorylation, gluconeogenesis and fatty acid synthesis. As modifications affecting both mitochondrial and lipid metabolism contribute to the initiation and/or progression of liver steatosis, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), a link between disrupted PGC1 pathways and onset of these pathological conditions has been postulated. Read More
Sci Rep 2018 Dec 5;8(1):17662. Epub 2018 Dec 5.
Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Carbon nanotubes exhibit mechanical properties ideally suited for reinforced structural composites and surface area and conductivity attractive for electrochemical capacitors. Here we demonstrate the multifunctional synergy between these properties in a composite material exhibiting simultaneous mechanical and energy storage properties. This involves a reinforcing electrode developed using dense, aligned carbon nanotubes grown on stainless steel mesh that is layered in an ion conducting epoxy electrolyte matrix with Kevlar or fiberglass mats. Read More
Sci Rep 2018 Dec 5;8(1):17642. Epub 2018 Dec 5.
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
Recent studies on tissue-autonomous serotonin (5-hydroxytryptamine [5-HT]) function have identified new roles for 5-HT in peripheral organs. Most of these studies were performed by crossing mice carrying the Tph1 allele with tissue specific Cre mice. In the present study, we found that 5-HT production was not completely abolished in Tph1 KO mice. Read More
Open Biol 2018 Dec 5;8(12). Epub 2018 Dec 5.
PhD Program for Translational Medicine, China Medical University and Academia Sinica, Taiwan, Republic of China
Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disease that is characterized by a triad of motor, psychiatric and cognitive impairments. There is still no effective therapy to delay or halt the disease progress. The striatum and cortex are two particularly affected brain regions that exhibit dense reciprocal excitatory glutamate and inhibitory gamma-amino butyric acid (GABA) connections. Read More
Clin Sci (Lond) 2018 Dec 5;132(23):2469-2481. Epub 2018 Dec 5.
University of Edinburgh/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, The University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, U.K.
The renin-angiotensin system (RAS) is highly conserved, and components of the RAS are present in all vertebrates to some degree. Although the RAS has been studied since the discovery of renin, its biological role continues to broaden with the identification and characterization of new peptides. The evolutionarily distant zebrafish is a remarkable model for studying the kidney due to its genetic tractability and accessibility for imaging. Read More
Syst Rev 2018 Dec 5;7(1):224. Epub 2018 Dec 5.
Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada.
Background: A growing number of postdoctoral scholars are following diverse career paths that require broad skill sets to ensure success. Yet, most postdoctoral professional learning and development initiatives are intended for academic careers and seldom include professional skills needed to succeed in non-academic settings. Given that fewer than 20% of postdoctoral scholars will obtain tenure-track academic positions, there is a great need for postdoctoral scholars to prepare for a range of future careers. Read More
BMC Pulm Med 2018 Dec 5;18(1):186. Epub 2018 Dec 5.
Department of Respiratory Medicine, Allergology and Sleep Medicine, General Hospital Nuremberg, Nuremberg, Germany.
Background: There is a lack of robust data about factors predicting continuation (or termination) of positive airway pressure therapy (PAP) for sleep apnea. This analysis of big data from a German homecare provider describes patients treated with PAP, analyzes the therapy termination rate over the first year, and investigates predictive factors for therapy termination.
Methods: Data from a German homecare service provider were analyzed retrospectively. Read More
Virulence 2018 Dec 5. Epub 2018 Dec 5.
a Department of Molecular Biology , Umeå University , Umeå , Sweden.
The Gram-negative enteropathogen Yersinia pseudotuberculosis possesses a number of regulatory systems that detect cell envelope damage caused by noxious extracytoplasmic stresses. The CpxA sensor kinase and CpxR response regulator two-component regulatory system is one such pathway. Active Cpx signalling upregulates various factors designed to repair and restore cell envelope integrity. Read More
Future Med Chem 2018 Dec 6. Epub 2018 Dec 6.
School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, 693 Xiongchu Avenue, Wuhan 430073, PR China.
Enzymes play critical roles in the physiological and pathological processes of living systems. To provide detailed pictures of enzyme activity at the molecular and cellular levels, interdisciplinary studies of chemistry and biology have led to the emergence of many smart fluorescent probes, which emit fluorescence or show a shifted signal only upon interaction with their targets. With distinct advantage of a higher signal-to-noise ratio than traditional 'always on' probes, smart fluorescent probes enable sensitive detection of enzymes with clinical significance. Read More
J Audiol Otol 2018 Dec 7. Epub 2018 Dec 7.
Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University Boramae Medical Center, Seoul, Korea.
Background And Objectives: : The aim of the present study was to assess the feasibility of a PC-based facial asymmetry assessment program (PC-FAAP) and to compare the results of PC-FAAP with subjective regional scoring by raters in acute unilateral peripheral facial nerve paralysis (FNP).
Subjects And Methods: : Participants were divided into 3 groups with 8 participants per group: group I, normal; group II, mild to moderate FNP; and group III, severe FNP. Using the PC-FAAP, the mouth asymmetry ratio (MAR), eyebrow asymmetry ratio (EAR), and complete eye closure asymmetry ratio (CAR) were calculated by comparing the movement of tracking points on both sides. Read More
Molecules 2018 Dec 4;23(12). Epub 2018 Dec 4.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China.
Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed in many cancers, where it impedes differentiation and contributes to cancer cell proliferation, cell metastasis and invasiveness, and is associated with inferior prognosis. Pharmacological inhibition of LSD1 has been reported to significantly attenuate tumor progression in vitro and in vivo in a range of solid tumors and acute myeloid leukemia. Read More
Nutrients 2018 Dec 4;10(12). Epub 2018 Dec 4.
Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St. Lucia QLD 4072, Australia.
Eating behaviour in humans is a complex trait that involves sensory perception. Genetic variation in sensory systems is one of the factors influencing perception of foods. However, the extent that these genetic variations may determine food choices in a real meal scenario warrants further research. Read More
Dtsch Med Wochenschr 2018 Dec 3;143(24):1774-1777. Epub 2018 Dec 3.
Klinik Schillerhöhe, Abteilung für Pneumologie und Beatmungsmedizin, Gerlingen, Robert-Bosch-Krankenhaus.
Interstitial lung diseases compromise a group of diffuse predominantly chronic inflammatory and fibrosing disorders of the lung parenchyma. This article reviews practice-relevant publications on the diagnosis and treatment of idiopathic pulmonary fibrosis - the most common form of idiopathic interstitial lung diseases. The new patient questionnaire of the German Society of Pneumology facilitates collection of a complex case history of diverse interstitial lung diseases in individual patients. Read More
Med Probl Perform Art 2018 Dec;33(4):275-285
Research Centre for Sport Exercise and Performance, WH214 Performance Hub, University of Wolverhampton, Gorway Road, Walsall WS1 3BD, UK. Tel +44 1902 323194.
Aim: Due to movement complexity and the use of interdisciplinary styles, all theatrical dance genres require dancers to have excellent balance skills to meet choreographic demands. The aim of this systematic review was to evaluate the experimental evidence for the relationship between balance and dance performance, including balance testing, balance training, and balance performance. The key focus was on balance and theatrical styles of dance, involving adult participants who were either in full-time dance training or professional dancers. Read More
Behav Brain Res 2018 Nov 30. Epub 2018 Nov 30.
Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310012, PR China; Center for Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, Hangzhou 310058, PR China.
Non-human primates have become one of the most important model animals for the investigation of brain diseases because they share a wide-range of genetics and social similarities with human beings. Naturally-evoked depression models in macaques may offer a full spectrum of similarity to human depression states, but they require validation and corroboration of specific phenotypes to depression-associated states before they can be used in research into more effective interventions. It is reported here that depressed cynomolgus monkeys developed in the natural condition display higher levels of typical depressive-like huddling behavior than healthy monkeys. Read More
Genomics 2018 Nov 30. Epub 2018 Nov 30.
CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos, s/n, Porto 4450-208, Portugal; Department of Biology, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal. Electronic address:
The Harderian gland is a cephalic structure, widely distributed among vertebrates. In snakes, the Harderian gland is anatomically connected to the vomeronasal organ via the nasolacrimal duct, and in some species can be larger than the eyes. The function of the Harderian gland remains elusive, but it has been proposed to play a role in the production of saliva, pheromones, thermoregulatory lipids and growth factors, among others. Read More
Intest Res 2018 Dec 3. Epub 2018 Dec 3.
Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, India.
Background/aims: Cronobacter sakazakii, an emergent pathogen is considered as a major concern to infants and neonates fed on reconstituted powdered infant milk formula. In conjunction with many other factors, biofilm forming capacity adds to its pathogenic potential. In view of the facts that infants are at highest risk to C. Read More
Ginekol Pol 2018 ;89(11):587-592
Frauenzimmer Bern AG, Bern, Switzerland.
Objectives: The need for pelvic floor surgery will increase with an aging population in the future. Aim of this prospective study was to evaluate the evolution of cognitive function in elderly women after urogynaecological surgery.
Material And Methods: Between 2010 and 2014, 51 female patients 70 years and older who underwent urogynaecological surgery participated in this study. Read More
J Mol Cell Biol 2018 Dec 3. Epub 2018 Dec 3.
National Center of Mathematics and Interdisciplinary Sciences, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, PR China.
Analysis linking directly genomics, neuroimaging phenotypes and clinical measurements is crucial for understanding psychiatric disorders, but remains rare. Here, we describe a multi-scale analysis using genome-wide SNPs, gene-expression, grey matter volume (GMV) and the Positive and Negative Syndrome Scale scores (PANSS) to explore the etiology of schizophrenia. With 72 drug-naive schizophrenic first episode patients (FEPs) and 73 matched heathy controls, we identified 108 genes, from schizophrenia risk genes, that correlated significantly with GMV, which are highly co-expressed in the brain during development. Read More
Chem Commun (Camb) 2018 Dec 3. Epub 2018 Dec 3.
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 37673, Korea and Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Korea.
A functional glycan chip combined with on-chip enzymatic glycosylation was developed to prepare complex glycan sources and to apply glycan-involved applications simultaneously. GM3 trisaccharide, GM2 tetrasaccharide, and GM1 pentasaccharide were successfully directly biosynthesized on lactose-immobilized surfaces through three consecutive glycosyltransferase reactions along with small amounts of enzymes and donors, without any additional processes. Biosynthesized GM1 pentasaccharide-related complex glycans were demonstrated to provide information on the substrate specificity of whole cholera toxin. Read More
J Vis Exp 2018 Nov 17(141). Epub 2018 Nov 17.
Interdisciplinary Stem Cell Institute, University of Miami Leonard M. Miller School of Medicine; Department of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine; Vascular Biology Institute, University of Miami Leonard M. Miller School of Medicine; Peggy and Harold Katz Family Drug Discovery Center, University of Miami Leonard M. Miller School of Medicine;
The regulation of LDL cholesterol uptake through LDLR-mediated endocytosis is an important area of study in various major pathologies including metabolic disorder, cardiovascular disease, and kidney disease. Currently, there is no available method to assess LDL uptake while simultaneously monitoring for health of the cells. The current study presents a protocol, using a live cell imaging analysis system, to acquire serial measurements of LDL influx with concurrent monitoring for cell health. Read More
J Vis Exp 2018 Nov 16(141). Epub 2018 Nov 16.
Department of Operative Dentistry and Periodontology, Rostock University Medical Center.
To date, several stem cell types at different developmental stages are in the focus for the treatment of degenerative diseases. Yet, certain aspects, such as initial massive cell death and low therapeutic effects, impaired their broad clinical translation. Genetic engineering of stem cells prior to transplantation emerged as a promising method to optimize therapeutic stem cell effects. Read More
Implant Dent 2018 Nov 30. Epub 2018 Nov 30.
Professor, Division of Clinical Medicine, Department of Oral and Maxillofacial Surgery, Graduate Faculty of Interdisciplinary, University of Yamanashi, Yamanashi, Japan.
Purpose: We investigated whether it was possible to perform a sinus lift maintaining absorbable screw material with biological activity.
Materials And Methods: Thirty rabbits were used. The screws used in this study were unsintered hydroxyapatite/poly-L-lactic acid (uHA/PLLA) (uHA/PLLA group) and titanium alloy (Ti group). Read More
J Pediatr Rehabil Med 2018 Nov 20. Epub 2018 Nov 20.
Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Purpose: To describe the development and implementation of the Children's of Alabama (COA) Spina Bifida (SB) Lifetime-Care-Model, including standardized care protocols and transition plan.
Methods: In 2010, members of the pediatric team at COA began to evaluate limitations in access to care for patients with SB at various stages of life. Through clinic surveys, observations, and caregiver report, a Lifetime-Care-Model was developed and implemented. Read More
Plant Signal Behav 2018 Dec 3:1-4. Epub 2018 Dec 3.
d Department of Applied Plant Science, Graduate School of Agricultural Science , Tohoku University , Sendai , Japan.
Autophagy is an evolutionarily conserved system that degrades intracellular components including proteins and organelles, and is important in the adaptive response to starvation in various eukaryotic organisms. Plant chloroplasts convert light energy into chemical energy and assimilate atmospheric carbon dioxide (CO) for carbohydrate production through photosynthesis reactions. We previously described an autophagy process for chloroplast degradation, during which a portion of chloroplasts are mobilized into the vacuole via autophagic vesicles termed Rubisco-containing bodies. Read More
Neuropsychopharmacol Rep 2018 Dec 11;38(4):167-174. Epub 2018 Aug 11.
Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
Aim: To explore the characteristics of psychiatric morbidity in chronic pain patients who present with or without fibromyalgia.
Methods: Patients are referred to our chronic pain clinic from primary medical institutions, as we are a secondary medical institution. Although some patients have chronic pain, they have no clear organic disorder such as rheumatoid arthritis to account for the pain. Read More
J Dtsch Dermatol Ges 2018 Dec 3. Epub 2018 Dec 3.
Department of Dermatology, Venereology and Allergology, Academic Teaching Department of Medical University Innsbruck, Central Hospital Bolzano/Bozen, Italy.