47,632 results match your criteria Interactive Teledermatology


[Introduction: Health literacy refers to the competences and resources required by individuals to meet the complex demands of health in modern society. This paper describes and analyses the health literacy profiles of type 2 diabetic patients included in a 2-year long self-management education programme.Methods: Nested in the ERMIES randomized controlled trial conducted in Reunion island, the ERMIES Ethnosocio study explored health literacy by means of two complementary approaches: description of health literacy profiles via the French version of the multidimensional “Health Literacy Questionnaire”, and a socio-anthropological perspective based on 40 semi-structured interviews carried out in 2012 and then in 2015.Results: The results highlight the existence of 8 constitutive variables in the management of type 2 diabetes in an ordinary context: diet, physical activity, treatment and monitoring of disease (disease management), access to knowledge and skills (health knowledge), relationships with health professionals and social support (expertise, support and social network). They also emphasize the differentiated relationships of individuals to each of these variables, ranging from functional to interactive or critical “levels”.Discussion].

Sante Publique 2018 Sep;S2(HS2):145-156

Introduction: Health literacy refers to the competences and resources required by individuals to meet the complex demands of health in modern society. This paper describes and analyses the health literacy profiles of type 2 diabetic patients included in a 2-year long self-management education programme.

Methods: Nested in the ERMIES randomized controlled trial conducted in Reunion island, the ERMIES Ethnosocio study explored health literacy by means of two complementary approaches: description of health literacy profiles via the French version of the multidimensional ?Health Literacy Questionnaire?, and a socio-anthropological perspective based on 40 semi-structured interviews carried out in 2012 and then in 2015. Read More

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September 2018

Understanding Patient Preferences and Unmet Needs in Non-alcoholic Steatohepatitis (NASH): Insights from a Qualitative Online Bulletin Board Study.

Adv Ther 2018 Dec 13. Epub 2018 Dec 13.

Novartis Healthcare Pvt Ltd, Hyderabad, India.

Introduction: The aim of this work was to understand how patients with non-alcoholic steatohepatitis (NASH) perceive their disease, unmet needs, and expectations regarding future treatment through online bulletin board (OBB) qualitative research.

Methods: OBB is an asynchronous online qualitative market research tool that provides an open forum for interactive discussion among participants. Patients with NASH were recruited via physician referral and completed a screener questionnaire to ensure their eligibility and willingness to participate. Read More

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December 2018

Development of an Interactive Dashboard to Analyze Cognitive Workload of Surgical Teams During Complex Procedural Care.

IEEE Int Interdiscip Conf Cogn Methods Situat Aware Decis Support 2018 Jun 2;2018:77-82. Epub 2018 Aug 2.

Department of Anesthesia, MGH, Harvard Medical School, Boston, USA.

In the surgical setting, team members constantly deal with a high-demand operative environment that requires simultaneously processing a large amount of information. In certain situations, high demands imposed by surgical tasks and other sources may exceed team member's cognitive capacity, leading to cognitive overload which may place patient safety at risk. In the present study, we describe a novel approach to integrate an objective measure of team member's cognitive load with procedural, behavioral and contextual data from real-life cardiac surgeries. Read More

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Integrating design thinking with sustainability science: a Research through Design approach.

Sustain Sci 2018 20;13(6):1565-1587. Epub 2018 Aug 20.

1School of Earth and Environmental Science, The University of Queensland, Brisbane, QLD Australia.

Design disciplines have a long history of creating well-integrated solutions to challenges which are complex, uncertain and contested by multiple stakeholders. Society faces similar challenges in implementing the Sustainable Development Goals, so design methods hold much potential. While principles of good design are well established, there has been limited integration of design thinking with sustainability science. Read More

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Asclepias Syriaca (Common Milkweed) flowering date shift in response to climate change.

Authors:
Aaron F Howard

Sci Rep 2018 Dec 13;8(1):17802. Epub 2018 Dec 13.

Biology Department, Franklin & Marshall College, Lancaster, 17604, USA.

The consequences of altered flowering dates due to climate change can be severe, especially for plants that rely on coordinated flower and pollinator emergence for reproduction. The plant Asclepias syriaca (Common Milkweed) relies on pollinators for movement of its pollen and evidence suggests that it has recently been declining. Given these factors and this plant's importance as a host species for the declining Danaus plexippus (Monarch Butterfly), it is critical to determine if its flowering is being modified by climate change. Read More

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December 2018

Radiologist Adoption of Interactive Multimedia Reporting Technology.

J Am Coll Radiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA. Electronic address:

Purpose: To determine if radiologists find enough value in available interactive multimedia reporting technology to routinely adopt it into clinical practice.

Materials And Methods: Our institution's reporting application (Vue Reporting, Carestream Health) allows the incorporation of multimedia elements, including active hyperlinks, into clinical reports, but would radiologists find enough value in this technique to change their practice? We retrospectively reviewed 559,841 diagnostic reports issued July 2016 to February 2018 for the presence of text hyperlinks that interactively connect to imaging findings in the PACS. Results were subdivided by modality, reporting radiologist role (ie, resident, fellow, attending physician), and subspecialty. Read More

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December 2018

Clinical assessment of depth sensor based pose estimation algorithms for technology supervised rehabilitation applications.

Int J Med Inform 2019 Jan 8;121:30-38. Epub 2018 Nov 8.

Nottinghamshire Healthcare NHS Foundation Trust, Stapleford Care Centre, Nottingham, NG9 8DB, United Kingdom.

Encouraging rehabilitation by the use of technology in the home can be a cost-effective strategy, particularly if consumer-level equipment can be used. We present a clinical qualitative and quantitative analysis of the pose estimation algorithms of a typical consumer unit (Xbox One Kinect), to assess its suitability for technology supervised rehabilitation and guide development of future pose estimation algorithms for rehabilitation applications. We focused the analysis on upper-body stroke rehabilitation as a challenging use case. Read More

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January 2019

Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota.

Microbiome 2018 Dec 13;6(1):224. Epub 2018 Dec 13.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Science, China Agricultural University, No. 2, West Yuanmingyuan Road, Beijing, 100193, People's Republic of China.

Background: Antibiotics are commonly used worldwide, and pesticide is a kind of xenobiotic to which humans are frequently exposed. The interactive impact of antibiotics on pesticides has rarely been studied. We aim to investigate the effects of antibiotics on the pesticide exposure risk and whether gut microbiota altered by antibiotics has an influence on pesticide bioavailability. Read More

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December 2018
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Paper-Based Magneto-Resistive Sensor: Modeling, Fabrication, Characterization, and Application.

Sensors (Basel) 2018 Dec 11;18(12). Epub 2018 Dec 11.

Institute of Microtechnology, Department of Mechanical Engineering, Braunschweig University of Technology, 38124 Braunschweig, Germany.

In this work, we developed and fabricated a paper-based anisotropic magneto-resistive sensor using a sputtered permalloy (Ni 81 Fe 19 ) thin film. To interpret the characteristics of the sensor, we proposed a computational model to capture the influence of the stochastic fiber network of the paper surface and to explain the physics behind the empirically observed difference in paper-based anisotropic magneto-resistance (AMR). Using the model, we verified two main empirical observations: (1) The stochastic fiber network of the paper substrate induces a shift of 45 ∘ in the AMR response of the paper-based Ni 81 Fe 19 thin film compared to a Ni 81 Fe 19 film on a smooth surface as long as the fibrous topography has not become buried. Read More

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December 2018

Interactive Dyadic Physical Activity and Spatial Proximity Patterns in 2-Year-Olds and Their Parents.

Children (Basel) 2018 Dec 11;5(12). Epub 2018 Dec 11.

Department of Biobehavioral Sciences, Columbia University Teachers College, New York, NY 10027, USA.

This study aimed to characterize daily physical activity (PA) behaviors in 2-year-old girls and boys and their parents, with and without an objective measure of dyadic spatial proximity. Urban-dwelling parent⁻toddler dyads ( = 110) wore accelerometers for 7 days, and parents completed a sociodemographic questionnaire. Accelerometers were initialized to collect PA and Bluetooth-based proximity data. Read More

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December 2018

The Cultural Cognitive Development of Personal Beliefs and Classroom Behaviours of Adult Language Instructors: A Qualitative Inquiry.

Brain Sci 2018 Dec 11;8(12). Epub 2018 Dec 11.

Woosong Language Institute, Woosong University, Daejeon 34514, Korea.

The researcher employed personal belief system (PBS) theory as the theoretical foundation for this study because it holds that teachers' PBSs may influence their teaching behaviours, teaching styles, and pedagogies in classroom practice due to cultural influences. The purpose of this qualitative study was to explore how teachers' personal beliefs influence how they teach and how their approach may align with or diverge from cultural expectations in a private adult learning facility for English learning in Macau Special Administrative Region, China. The participants in this study were classroom teachers in a learning community who believe in collaborating to create environments for best practices. Read More

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December 2018

Beacons and BIM Models for Indoor Guidance and Location.

Sensors (Basel) 2018 Dec 11;18(12). Epub 2018 Dec 11.

ISTAR-IUL, Instituto Universitário de Lisboa (ISCTE-IUL), Lisboa 1649-026, Portugal.

This research work uses a simplified approach to combine location information from a beacon's propagation signal interaction with a mobile device sensor (accelerometer and gyroscope) with local building information to give real-time location and guidance to a user inside a building. This is an interactive process with visualisation information that can help user's orientation inside unknown buildings and the data stored from different users can provide useful information about users' movements inside a public building. Beacons installed on the building at specific pre-defined positions emit signals that give a geographic position with an associated imprecision, related with Bluetooth's range. Read More

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December 2018

Evaluation of a Push-Pull System for the Management of Species (Thysanoptera: Thripidae) in Tomato.

Insects 2018 Dec 7;9(4). Epub 2018 Dec 7.

US Horticultural Research Laboratory, USDA-ARS, Fort Pierce, FL 34945, USA.

A push-pull strategy for reducing populations of the thrips (Pergande), (Morgan) and (Fitch) in tomato was evaluated. Push components consisted of ultraviolet (UV)-reflective mulch and foliar applications of kaolin and the pull component consisted of the companion plant (L.). Read More

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December 2018

Definition of a safe zone for screw fixation of posterior talar process fracture by 3-dimensional technology.

Medicine (Baltimore) 2018 Dec;97(49):e13331

Department of Orthopaedic Surgery, The Affiliated Hospital of Medical School, Ningbo University.

Background: Percutaneous screw fixation can provide stable fixation with a minimally invasive surgical technique for posterior talar process fracture.

Objectives: The purpose of this study was to investigate the optimal posterior screw placement and the geometry of safe zone for screw insertion in the posterior talar process by analyzing with 3-dimensional (3D) technology.

Methods: 100 adult feet computed tomography (CT) scans were evaluated. Read More

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December 2018

CLDN10 single nucleotide polymorphism rs1325774 alters the risk of breast cancer in south chinese women.

Medicine (Baltimore) 2018 Dec;97(49):e13187

Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region.

Breast cancer is one of the most widespread malignancies in females, and the incidence rate has been increasing in recent years in the world. Genetic factors play an important role in the occurrence of breast cancer. Our study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of claudin 10 (CLDN10) (rs1325774, rs7333503, rs3751334) and breast cancer and the clinical characteristics of patients. Read More

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December 2018

A real-time optimal inverse planning for Gamma Knife radiosurgery by convex optimization: description of the system and first dosimetry data.

Authors:

J Neurosurg 2018 Dec;129(Suppl1):111-117

OBJECTIVEThe authors developed a new, real-time interactive inverse planning approach, based on a fully convex framework, to be used for Gamma Knife radiosurgery.METHODSThe convex framework is based on the precomputation of a dictionary composed of the individual dose distributions of all possible shots, considering all their possible locations, sizes, and shapes inside the target volume. The convex problem is solved to determine the plan, i. Read More

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December 2018

Examining the link between reward and response inhibition in individuals with substance abuse tendencies.

Drug Alcohol Depend 2018 Dec 3;194:518-525. Epub 2018 Dec 3.

Department of Psychological and Brain Sciences, Texas A and M University, 400 Bizzell St., College Station, TX, 77843, USA.

Background: Substance use problems are often characterized by dysregulation in reward sensitivity and inhibitory control. In line with this representation, the goal of this investigation was to determine how substance abuse tendencies among university students affect incentivized response inhibition. Additionally, this study examined whether striatal dopamine moderates the impact of substance use on response inhibition performance. Read More

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December 2018

Advance Care Planning Among Patients With Advanced Cancer.

J Oncol Pract 2018 Dec 13:JOP1800044. Epub 2018 Dec 13.

The Pennsylvania State University, College of Medicine, Hershey, PA.

Purpose:: Advance directives (AD) have been heralded as vehicles to promote patient autonomy and have been decried as ineffective. Efforts to improve advance care planning (ACP) and AD documents are wide ranging but have not been prospectively studied.

Materials And Methods:: In an institutional review board-approved, single-blind, randomized, controlled trial, we compared an interactive, educational ACP decision aid to standard ACP among patients with advanced cancer. Read More

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December 2018

Student acceptance of e-learning methods in the laboratory class in Optometry.

PLoS One 2018 13;13(12):e0209004. Epub 2018 Dec 13.

School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand.

Today's students have increased expectations for flexible learning options and evidence-based practice resources to be available to support curricular activities. We investigated: (i) the suitability of a static website for teaching ocular anatomy and physiology and an interactive version of the website with quiz and self-assessment activities and (ii) the usefulness of a blended online and in-lab environment to teach in Optometry. We administered a survey to compare responses of optometry students who had access to the interactive website, with those from students from a previous year who used the static version. Read More

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December 2018

Full-Length Envelope Analyzer (FLEA): A tool for longitudinal analysis of viral amplicons.

PLoS Comput Biol 2018 Dec 13;14(12):e1006498. Epub 2018 Dec 13.

Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA.

Next generation sequencing of viral populations has advanced our understanding of viral population dynamics, the development of drug resistance, and escape from host immune responses. Many applications require complete gene sequences, which can be impossible to reconstruct from short reads. HIV env, the protein of interest for HIV vaccine studies, is exceptionally challenging for long-read sequencing and analysis due to its length, high substitution rate, and extensive indel variation. Read More

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December 2018

Evaluation of Changes in the Motor Network Following BCI Therapy Based on Graph Theory Analysis.

Front Neurosci 2018 27;12:861. Epub 2018 Nov 27.

Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States.

Despite the established effectiveness of the brain-computer interface (BCI) therapy during stroke rehabilitation (Song et al., 2014a, 2015; Young et al., 2014a,b,c, 2015; Remsik et al. Read More

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November 2018

[Association between life space and health literacy in community-dwelling older adults].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):650-656

Department of Community Health Sciences, Kobe University, Graduate School of Health Sciences.

Aim: To examine the association between health literacy (HL) and life space in community-dwelling older adults.

Methods: In this cross-sectional study, we analyzed 210 community-dwelling older adults (mean age: 74.6 years, women: 63. Read More

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January 2018

Application of geographic information systems and simulation modelling to dental public health: Where next?

Community Dent Oral Epidemiol 2018 Dec 7. Epub 2018 Dec 7.

Unit of Oral Health, Dentistry and Society, School of Clinical Dentistry, University of Sheffield, Sheffield, UK.

Public health research in dentistry has used geographic information systems since the 1960s. Since then, the methods used in the field have matured, moving beyond simple spatial associations to the use of complex spatial statistics and, on occasions, simulation modelling. Many analyses are often descriptive in nature; however, and the use of more advanced spatial simulation methods within dental public health remains rare, despite the potential they offer the field. Read More

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December 2018

Adsorption of Potentially Toxic Metals from Mono and Multi-Metal Systems Using Groundnut and Shea Nut Shell Biochars.

J Health Pollut 2018 Jun 11;8(18):180602. Epub 2018 Jun 11.

Department of Ecotourism and Environmental Management, Faculty of Natural Resources and Environment, University for Development Studies, Tamale, Ghana.

Background: Adsorption is a unique and promising method for the removal of trace metals from an aqueous environment using cost-effective and readily available biochars.

Objective: The present study examined mono and simultaneous adsorption of cadmium (Cd), mercury (Hg) and lead (Pb) onto biochars produced at pyrolysis temperatures of 350 ± 5°C and 700 ± 5°C.

Methods: Fifty mg/l of trace metal ions with 2 g/50 ml of adsorbent dosage were leached at constant room temperature of 24 ± 0. Read More

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The Effects of Combined Abiotic and Pathogen Stress in Plants: Insights From Salinity and pv Interaction in Cucumber.

Front Plant Sci 2018 20;9:1691. Epub 2018 Nov 20.

Department of Plant Biotechnology and Cytogenetics, Plant Breeding and Acclimatization Institute - National Research Institute, Radzików, Poland.

Plants are often challenged by abiotic and biotic stresses acting in combination and the response to combinatorial stress differs from that triggered by each factor individually. Although salinity and pathogens are major stressors limiting plant growth and productivity worldwide, their interaction is poorly understood. The reactions to pathogens overlap with those to abiotic stresses, and reactive oxygen species (ROS) and stress hormones represent central nodes in the interacting signaling pathways. Read More

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November 2018

Gait Stability Training in a Virtual Environment Improves Gait and Dynamic Balance Capacity in Incomplete Spinal Cord Injury Patients.

Front Neurol 2018 20;9:963. Epub 2018 Nov 20.

Department of Research, Sint Maartenskliniek, Nijmegen, Netherlands.

Many patients with incomplete spinal cord injury (iSCI) have impaired gait and balance capacity, which may impact daily functioning. Reduced walking speed and impaired gait stability are considered important underlying factors for reduced daily functioning. With conventional therapy, patients are limited in training gait stability, but this can be trained on a treadmill in a virtual environment, such as with the Gait Real-time Analysis Interactive Lab (GRAIL). Read More

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November 2018

Rough sets: past, present, and future.

Nat Comput 2018 25;17(4):855-876. Epub 2018 Jul 25.

3Vistula University, Stokłosy 3, 02-787 Warsaw, Poland.

Introduction of rough sets by Professor Zdzisław Pawlak has completed 35 years. The theory has already attracted the attention of many researchers and practitioners, who have contributed essentially to its development, from all over the world. The methods, developed based on rough set theory alone or in combination with other approaches, found applications in many areas. Read More

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De-Novo Ligand Design against Mutated Huntington Gene by Ligand-Based Pharmacophore Modeling Approach.

Curr Comput Aided Drug Des 2018 Dec 6. Epub 2018 Dec 6.

Department of Mechanical Engineering (SMME), National University of Science and Technology, Islamabad . Pakistan.

Background: Huntington's disease is characterized by three side effects, including motor disturbances, psychiatric elements, and intellectual weakness. The onset for HD has nonlinear converse associations with the number of repeat sequences of the polyglutamine mutations, so that younger patients have a tendency for longer repeats length. This HD variation is because of a development of a polyglutamine (CAG) repeats in the exon 1 of the Huntingtin protein. Read More

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December 2018

Alternative Modes of Mechanical Ventilation.

Authors:
John J Gallagher

AACN Adv Crit Care 2018 ;29(4):396-404

John J. Gallagher is Trauma Program Manager/Clinical Nurse Specialist at Penn Presbyterian Medical Center, 51 N 39th Street, Medical Office Building, Suite 120, Philadelphia, PA 19104

Modern mechanical ventilators are more complex than those first developed in the 1950s. Newer ventilation modes can be difficult to understand and implement clinically, although they provide more treatment options than traditional modes. These newer modes, which can be considered alternative or nontraditional, generally are classified as either volume controlled or pressure controlled. Read More

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January 2018

Capturing Expert Knowledge for the Personalization of Cognitive Rehabilitation: Study Combining Computational Modeling and a Participatory Design Strategy.

JMIR Rehabil Assist Technol 2018 Dec 6;5(2):e10714. Epub 2018 Dec 6.

Madeira Interactive Technologies Institute, Funchal, Portugal.

Background: Cognitive impairments after stroke are not always given sufficient attention despite the critical limitations they impose on activities of daily living (ADLs). Although there is substantial evidence on cognitive rehabilitation benefits, its implementation is limited because of time and human resource's demands. Moreover, many cognitive rehabilitation interventions lack a robust theoretical framework in the selection of paper-and-pencil tasks by the clinicians. Read More

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December 2018

Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia (iLLUMINATE): a multicentre, randomised, open-label, phase 3 trial.

Lancet Oncol 2018 Nov 30. Epub 2018 Nov 30.

Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN, USA.

Background: Both single-agent ibrutinib and chlorambucil plus obinutuzumab have shown superior efficacy to chlorambucil monotherapy and are standard first-line treatments in chronic lymphocytic leukaemia. We compared the efficacy of the combination of ibrutinib plus obinutuzumab with chlorambucil plus obinutuzumab in first-line chronic lymphocytic leukaemia or small lymphocytic lymphoma.

Methods: iLLUMINATE is a multicentre, randomised, open-label, phase 3 trial done at 74 academic and community hospitals in Australia, Canada, Israel, New Zealand, Russia, Turkey, the EU, and the USA in patients with previously untreated chronic lymphocytic leukaemia or small lymphocytic lymphoma, either aged 65 years or older or younger than 65 years with coexisting conditions. Read More

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November 2018

The virtual patient as a learning tool: a mixed quantitative qualitative study.

BMC Med Educ 2018 Dec 6;18(1):297. Epub 2018 Dec 6.

Invento: Creative Solutions for Health, Wellness & Education Corp, Vancouver, BC, Canada.

Background: The use of simulation in medical education has been widely accepted. There are different types of medical simulators that vary in both accuracy to emulate the real world (fidelity) and cost of development or acquisition. There is significant evidence that supports the use of high-fidelity simulators (i. Read More

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December 2018

Can patients be trained to expect shared decision making in clinical consultations? Feasibility study of a public library program to raise patient awareness.

PLoS One 2018 12;13(12):e0208449. Epub 2018 Dec 12.

Tier 1 Canada Research Chair in Shared Decision Making and Knowledge Translation, Université Laval, Quebec City (QC, Canada).

Introduction: Shared decision making (SDM) is a process whereby decisions are made together by patients and/or families and clinicians. Nevertheless, few patients are aware of its proven benefits. This study investigated the feasibility, acceptability and impact of an intervention to raise public awareness of SDM in public libraries. Read More

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December 2018

Development and Usability Testing of the Society for Pediatric Anesthesia Pedi Crisis Mobile Application.

Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.

United States National Aeronautics and Space Administration, Ames Research Center, Moffett Field, California.

When life-threatening, critical events occur in the operating room, the fast-paced, high-distraction atmosphere often leaves little time to think or deliberate about management options. Success depends on applying a team approach to quickly implement well-rehearsed, systematic, evidence-based assessment and treatment protocols. Mobile devices offer resources for readily accessible, easily updatable information that can be invaluable during perioperative critical events. Read More

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December 2018
1 Read

Muscle metaboreflex activation via postexercise ischemia as a tool for teaching cardiovascular physiology for undergraduate students.

Adv Physiol Educ 2019 Mar;43(1):34-41

NeuroV̇ASQ̇, Integrative Physiology Laboratory, Faculty of Physical Education, University of Brasília , Brasília , Brazil.

The cardiovascular responses to exercise are mediated by several interactive neural mechanisms, including central command, arterial baroreflex, and skeletal muscle mechano- and metaboreflex. In humans, muscle metaboreflex activation can be isolated via postexercise ischemia (PEI), which increases sympathetic nerve activity and partially maintains the exercise-induced increase in arterial blood pressure. Here, we describe a practical laboratory class using PEI as a simple and useful technique to teach cardiovascular physiology. Read More

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March 2019
1 Read

Decoding the Atlas of RNA Modifications from Epitranscriptome Sequencing Data.

Methods Mol Biol 2019 ;1870:107-124

Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou, China.

Over 100 types of chemical modifications have been identified in protein-coding and noncoding RNAs (ncRNAs). However, the prevalence, regulation, and function of diverse RNA modifications remain largely unknown. In this chapter, we describe how to annotate, visualize, and analyze the RNA modification sites from the high-throughput epitranscriptome sequencing data using RMBase platform and software. Read More

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January 2019
1 Read

Development of an analytical prepCheck-supported approach to evaluate tutor-based assessments of dental students' practical skills.

Int J Comput Dent 2018 ;21(4):313-322

The aim of the present study was to develop an analytical computer-supported assessment concept for the objective evaluation of students' practical skills, and to investigate the assessor-dependent differences by setting tolerance limits applied during the 'glance and grade' evaluation. A sample of 54 conventionally supervised dental undergraduates were given training in the preparation of a macroretentive Class II cavity. The course participants then took a mandatory practical examination. Read More

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January 2018

Toward the Development of SMART Communication Technology: Automating the Analysis of Communicative Trouble and Repair in Dementia.

Innov Aging 2018 Sep 3;2(3):igy034. Epub 2018 Dec 3.

School of Health and Rehabilitation Sciences, Faculty of Health and Behavioural Sciences, University of Queensland, Brisbane, Australia.

Background And Objectives: Communication difficulties have been reported as one of the most stress-inducing aspects of caring for people with dementia. Notably, with disease progression comes an increase in the frequency of communication difficulty and a reduction in the effectiveness of attempts to remedy breakdowns in communication. The aim of the current research was to evaluate the utility of an automated discourse analysis tool (i. Read More

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September 2018

Development, implementation and first insights of a time- and location-independent longitudinal postgraduate curriculum in emergency medicine.

GMS J Med Educ 2018 15;35(4):Doc44. Epub 2018 Nov 15.

University of Bern, Bern University Hospital, Inselspital, Department of Emergency Medicine, Bern, Switzerland.

There have been few reports on the implementation of a structured curriculum for emergency medicine, as emergency medicine is not yet an established medical specialty for training in many European countries, including Switzerland and Germany. Because of the non-plannable workload in the emergency setting, common training approaches are often difficult to implement. Need-assessments of emergency medicine trainees commonly identify a need for interactive, time-independent ways of learning that integrate modern forms of knowledge transfer. Read More

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November 2018
1 Read

Integrated analysis reveals key genes with prognostic value in lung adenocarcinoma.

Cancer Manag Res 2018 21;10:6097-6108. Epub 2018 Nov 21.

Department of Respiratory Medicine, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, People's Republic of China,

Background: Lung cancer is one of the most common malignant tumors. Despite advances in lung cancer therapies, prognosis of non-small-cell lung cancer is still unfavorable. The aim of this study was to identify the prognostic value of key genes in lung tumorigenesis. Read More

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November 2018

Transcriptomic meta-signatures identified in Anopheles gambiae populations reveal previously undetected insecticide resistance mechanisms.

Nat Commun 2018 12 11;9(1):5282. Epub 2018 Dec 11.

Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L35QA, UK.

Increasing insecticide resistance in malaria-transmitting vectors represents a public health threat, but underlying mechanisms are poorly understood. Here, a data integration approach is used to analyse transcriptomic data from comparisons of insecticide resistant and susceptible Anopheles populations from disparate geographical regions across the African continent. An unbiased, integrated analysis of this data confirms previously described resistance candidates but also identifies multiple novel genes involving alternative resistance mechanisms, including sequestration, and transcription factors regulating multiple downstream effector genes, which are validated by gene silencing. Read More

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December 2018
6 Reads

A manual-based intervention for carers of people with dementia and sleep disturbances: an acceptability and feasibility RCT.

Health Technol Assess 2018 Dec;22(71):1-408

Division of Psychiatry, Faculty of Brain Sciences, University College London, London, UK.

Background: It has been estimated that between 25% and 40% of people living with dementia suffer from sleep disturbances, and there are currently no known effective treatments. Sleep disturbances may be the direct result of dementia or due to other comorbidities, such as pain and limited mobility. If carers' sleep is also disturbed, carers too can become tired and stressed, and this sometimes results in the breakdown of care in the home. Read More

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December 2018
1 Read

Assessment of Postoperative Outcomes in Spinal Epidural Abscess Following Surgical Decompression.

Spine J 2018 Dec 8. Epub 2018 Dec 8.

Center for Spine Health, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA; Department of Neurosurgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA; Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA. Electronic address:

Background Context: A spinal epidural abscess (SEA) is a serious condition that may be managed with antibiotics alone or with decompressive surgery combined with antibiotics.

Purpose: The objectives of this study were to assess the clinical outcomes of SEA after surgical management and to identify the patient-level factors that are associated with outcomes following surgical decompression and removal of SEA.

Study Design/setting: Retrospective chart review analysis. Read More

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December 2018
8 Reads

The Effects of a Functional Three-dimensional (3D) Printed Knee Joint Simulator in Improving Anatomical Spatial Knowledge.

Anat Sci Educ 2018 Dec 7. Epub 2018 Dec 7.

Division of Industrial Design, School of Design and Environment, National University of Singapore, Singapore.

In recent decades, three-dimensional (3D) printing as an emerging technology, has been utilized for imparting human anatomy knowledge. However, most 3D printed models are rigid anatomical replicas that are unable to represent dynamic spatial relationships between different anatomical structures. In this study, the data obtained from a computed tomography (CT) scan of a normal knee joint were used to design and fabricate a functional knee joint simulator for anatomical education. Read More

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December 2018

Interactive Effects of Mixtures of Phototoxic PAHs.

Bull Environ Contam Toxicol 2018 Dec 10. Epub 2018 Dec 10.

Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components in complex mixtures derived from petroleum based products. PAHs are unique in their ability to absorb UV light, resulting in significant increases in acute toxicity. The objective of this study was to determine if mixtures of the phototoxic PAHs fluoranthene, pyrene, and anthracene conform to the additive model of toxicity. Read More

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December 2018
1 Read

PopViz: a webserver for visualizing minor allele frequencies and damage prediction scores of human genetic variations.

Bioinformatics 2018 Dec;34(24):4307-4309

The Charles Bronfman Institute for Personalized Medicine.

Summary: Next-generation sequencing (NGS) generates large amounts of genomic data and reveals about 20 000 genetic coding variants per individual studied. Several mutation damage prediction scores are available to prioritize variants, but there is currently no application to help investigators to determine the relevance of the candidate genes and variants quickly and visually from population genetics data and deleteriousness scores. Here, we present PopViz, a user-friendly, rapid, interactive, mobile-compatible webserver providing a gene-centric visualization of the variants of any human gene, with (i) population-specific minor allele frequencies from the gnomAD population genetic database; (ii) mutation damage prediction scores from CADD, EIGEN and LINSIGHT and (iii) amino-acid positions and protein domains. Read More

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December 2018
4 Reads

IVET, an Interactive Veterinary Education Tool.

J Anim Sci 2018 Dec 10. Epub 2018 Dec 10.

Graphics and Imaging Laboratory (GILAB), University of Girona, Girona, Catalonia.

The use of e-learning tools for medical teaching is a common practice, but similar tools do not exist for veterinary teaching. In this paper we present a fully web-based e-learning platform, denoted Interactive Veterinary Education Tool (IVET), which is designed to support teaching and learning in veterinary science. To make content creation easier, it provides theory, exercise, and image editors with functionalities to prepare exercises and theoretical content including two-dimensional (2D) images, three-dimensional (3D) models, and Digital Imaging and Communications in Medicine (DICOM) files, which can be manipulated by the users. Read More

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December 2018
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WIlsON: Web-based Interactive Omics VisualizatioN.

Bioinformatics 2018 Aug 23. Epub 2018 Aug 23.

Max Planck Institute for Heart and Lung Research, Bioinformatics Core Unit (BCU), Bad Nauheim, Germany.

Motivation: High throughput (HT) screens in the omics field are typically analyzed by automated pipelines that generate static visualizations and comprehensive spreadsheet data for scientists. However, exploratory and hypothesis driven data analysis are key aspects of the understanding of biological systems, both generating extensive need for customized and dynamic visualization.

Results: Here we describe WIlsON, an interactive workbench for analysis and visualization of multi-omics data. Read More

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August 2018
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Mixed reality holograms for heart surgery planning: first user experience in congenital heart disease.

Eur Heart J Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

The Intervention Centre, Oslo University Hospital, Rikshospitalet, Sognsvannsvn 20, Oslo, Norway.

Aims: Proof of concept and feasibility study for preoperative diagnostic use of mixed reality (MR) holograms of individual 3D heart models from standard cardiac computed tomography angiograms (CTA) images. Optimal repair for complex congenital heart disease poses high demands on 3D anatomical imagination. Three-dimensional printed heart models are increasingly used for improved morphological understanding during surgical and interventional planning. Read More

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December 2018
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Multi-disciplinary and shared decision-making approach in the management of organ-confined prostate cancer.

Arab J Urol 2018 Dec 6;16(4):367-377. Epub 2018 Aug 6.

Department of Urology, Aga Khan University, Karachi, Pakistan.

Decision-making in the management of organ-confined prostate cancer is complex as it is based on multi-factorial considerations. It is complicated by a multitude of issues, which are related to the patient, treatment, disease, availability of equipment(s), expertise, and physicians. Combination of all these factors play a major role in the decision-making process and provide for an interactive decision-making preferably in the multi-disciplinary team (MDT) meeting. Read More

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December 2018
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