93 results match your criteria Integrated Blood Pressure Control [Journal]


Potential use of a "Blood Pressure Action Sheet" for Indonesian patients with hypertension living in rural villages: a qualitative study.

Integr Blood Press Control 2018 10;11:93-103. Epub 2018 Dec 10.

Graduate School of Health, Discipline of Pharmacy, The University of Technology Sydney, NSW, Australia,

Purpose: The aim of the study was to obtain feedback on the layout, content, and potential use of a blood pressure (BP) action sheet, a purpose-designed written resource for Indonesian patients with hypertension.

Methods: Telephone interviews were conducted with 13 health professionals, 12 community health workers, and 12 patients in rural Yogyakarta, Indonesia, to explore their impressions of the BP action sheet, how the sheet might affect management of hypertension, and suggestions for improvement.

Results: Participants felt that the sheet presented useful information about achieving the target BP and managing hypertension. Read More

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https://www.dovepress.com/potential-use-of-a-blood-pressure-
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http://dx.doi.org/10.2147/IBPC.S152157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292234PMC
December 2018
6 Reads

Hypertension and transcatheter aortic valve replacement: parallel or series?

Integr Blood Press Control 2018 23;11:81-91. Epub 2018 Nov 23.

Department of Cardiology, Rush University Medical Center, Chicago, IL, USA.

Aortic stenosis (AS) is the most common valvular heart disease in the elderly and it causes significant morbidity and mortality. Hypertension is also highly prevalent in elderly patients with AS, and AS patients with hypertension have worse outcomes. Accurate assessment of AS severity and understanding its relationship with arterial compliance has become increasingly important as the options for valve management, particularly transcatheter interventions, have grown. Read More

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http://dx.doi.org/10.2147/IBPC.S177258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260138PMC
November 2018
1 Read

White coat syndrome and its variations: differences and clinical impact.

Integr Blood Press Control 2018 8;11:73-79. Epub 2018 Nov 8.

Department of Pharmacology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil,

Hypertension is closely linked to increased cardiovascular risk and development of target organ damage (TOD). Therefore, proper clinical follow-up and treatment of hypertensive subjects are mandatory. A great number of individuals present a variation on blood pressure (BP) levels when they are assessed either in the office or in the out-of-office settings. Read More

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http://dx.doi.org/10.2147/IBPC.S152761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233698PMC
November 2018
3 Reads

Exercise as a tool for hypertension and resistant hypertension management: current insights.

Integr Blood Press Control 2018 20;11:65-71. Epub 2018 Sep 20.

School of Health Sciences, University of Aveiro, Aveiro, Portugal,

Although there has been an observed progress in the treatment of hypertension, its prevalence remains elevated and constitutes a leading cause of cardiovascular disease development. Resistant hypertension is a challenge for clinicians, as the available treatment options have reduced success. Physical activity and exercise training play an important role in the management of blood pressure. Read More

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https://www.dovepress.com/exercise-as-a-tool-for-hypertensio
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http://dx.doi.org/10.2147/IBPC.S136028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159802PMC
September 2018
2 Reads

The effect of passive leg-raising maneuver on hemodynamic stability during anesthesia induction for adult cardiac surgery.

Integr Blood Press Control 2018 7;11:57-63. Epub 2018 Jun 7.

Cardiovascular Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Some cardiac patients do not tolerate the intravenous fluid load commonly administered before anesthesia induction. This study investigated preinduction passive leg-raising maneuver (PLRM) as an alternative method to fluid loading before cardiac anesthesia.

Methods And Materials: During a 6-month period, 120 adult elective heart surgery patients were enrolled in this study and allocated into 2 groups: PLRM group vs control group (n=60). Read More

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http://dx.doi.org/10.2147/IBPC.S126514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995276PMC
June 2018
7 Reads

Morning blood pressure surge: pathophysiology, clinical relevance and therapeutic aspects.

Integr Blood Press Control 2018 24;11:47-56. Epub 2018 May 24.

Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.

Morning hours are the period of the day characterized by the highest incidence of major cardiovascular events including myocardial infarction, sudden death or stroke. They are also characterized by important neurohormonal changes, in particular, the activation of sympathetic nervous system which usually leads to a rapid increase in blood pressure (BP), known as morning blood pressure surge (MBPS). It was hypothesized that excessive MBPS may be causally involved in the pathogenesis of cardiovascular events occurring in the morning by inducing hemodynamic stress. Read More

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http://dx.doi.org/10.2147/IBPC.S130277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973439PMC
May 2018
1 Read

Blood pressure control status and associated factors among adult hypertensive patients on outpatient follow-up at University of Gondar Referral Hospital, northwest Ethiopia: a retrospective follow-up study.

Integr Blood Press Control 2018 23;11:37-46. Epub 2018 Apr 23.

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Large segments of the hypertensive population in the world are either untreated or inadequately treated. The incidence of heart failure and mortality from cardiovascular complications of hypertension is high among patients with uncontrolled blood pressure (BP). But BP control status of hypertensive patients has not been investigated in the study area. Read More

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https://www.dovepress.com/blood-pressure-control-status-and-
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http://dx.doi.org/10.2147/IBPC.S150628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918628PMC
April 2018
11 Reads

An integrated program with home blood-pressure monitoring and village health volunteers for treating poorly controlled hypertension at the primary care level in an urban community of Thailand.

Integr Blood Press Control 2018 18;11:25-35. Epub 2018 Apr 18.

College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand.

Purpose: Hypertension (HT) is accountable for death in half of the patients suffering from heart disease and stroke. Many treatment strategies have been used, but little research exists on an integrated program with home blood pressure monitoring (HBPM) and village health volunteers (VHVs) in an urban area of Thailand. The present study aims to determine the effectiveness of the integrated program, HBPM, and VHVs in supporting the target population. Read More

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https://www.dovepress.com/an-integrated-program-with-home-bl
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http://dx.doi.org/10.2147/IBPC.S160548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912376PMC
April 2018
5 Reads

Masked hypertension and cardiovascular outcomes: an updated systematic review and meta-analysis.

Integr Blood Press Control 2018 5;11:11-24. Epub 2018 Jan 5.

Section of Heart Failure and Transplant, Division of Cardiovascular Diseases, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Background: As many as one-third of individuals with normal office blood pressure (BP) are diagnosed with masked hypertension (HTN) based on ambulatory BP measurements (ABPM). Masked HTN is associated with higher risk of sustained HTN (SH) and increased cardiovascular morbidity.

Methods: The present study was designed to systematically review cohort studies and assess the effects of masked HTN compared to normotension and SH on cardiovascular events and all-cause mortality. Read More

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http://dx.doi.org/10.2147/IBPC.S128947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759852PMC
January 2018
3 Reads

Free radical scavenging reverses fructose-induced salt-sensitive hypertension.

Integr Blood Press Control 2018 19;11:1-9. Epub 2017 Dec 19.

Department of Internal Medicine, Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI, USA.

We have previously reported that a moderate dietary supplementation of 20% fructose but not glucose leads to a salt-sensitive hypertension related to increased proximal sodium-hydrogen exchanger activity and increased renal sodium retention. We also found that while high salt increased renal nitric oxide formation, this was retarded in the presence of fructose intake. We hypothesized that at least part of the pathway leading to fructose-induced salt-sensitive hypertension could be due to fructose-induced formation of reactive oxygen species and inappropriate stimulation of renin secretion, all of which would contribute to an increase in blood pressure. Read More

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http://dx.doi.org/10.2147/IBPC.S147674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741067PMC
December 2017
8 Reads

Effects of voluntary exercise on blood pressure, angiotensin II, aldosterone, and renal function in two-kidney, one-clip hypertensive rats.

Integr Blood Press Control 2017 29;10:41-51. Epub 2017 Nov 29.

Department of Internal Medicine.

Spontaneous dynamic exercise promotes sympathoinhibition and decreases arterial pressure in two-kidney, one-clip (2K-1C) hypertensive rats. Renal sympathetic nerves stimulate renin secretion and increase renal tubular sodium reabsorption. We hypothesized that daily voluntary wheel running exercise by 2K-1C rats will decrease mean arterial pressure (MAP), plasma angiotensin II (Ang II), and aldosterone as well as normalize urinary sodium and potassium excretion independent of changes in glomerular filtration rate (GFR). Read More

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https://www.dovepress.com/effects-of-voluntary-exercise-on-b
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http://dx.doi.org/10.2147/IBPC.S147122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713705PMC
November 2017
7 Reads

Monitoring and management of hypertension with obesity in adolescents.

Authors:
Bonita Falkner

Integr Blood Press Control 2017 20;10:33-39. Epub 2017 Nov 20.

Department of Medicine and Pediatrics, Thomas Jefferson University, Philadelphia, PA, USA.

Largely due to the childhood obesity epidemic, there has been an increase in the prevalence of hypertension in children and adolescents. Obesity associated hypertension is the most common hypertension phenotype among adolescents. Approximately 30% of obese adolescents have elevated blood pressure (BP) or hypertension. Read More

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http://dx.doi.org/10.2147/IBPC.S125094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700763PMC
November 2017
4 Reads

Quality improvement project for managing elevated blood pressure in a primary care setting.

Integr Blood Press Control 2017 13;10:25-32. Epub 2017 Oct 13.

Ila Faye School of Nursing, University of the Incarnate Word, San Antonio, TX, USA.

Elevated blood pressure (BP) and prehypertension increase the risk of cardiovascular diseases, a national health concern. This article presents a quality improvement project implemented within a primary care setting that aimed at lowering cardiovascular risk by improving the identification, treatment, and follow-up of patients with elevated BP. This project was designed and implemented to address the identified deficiencies contributing to poor identification and follow-up of patients with elevated BP. Read More

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http://dx.doi.org/10.2147/IBPC.S137112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648301PMC
October 2017
5 Reads

Preeclampsia and cardiovascular disease: interconnected paths that enable detection of the subclinical stages of obstetric and cardiovascular diseases.

Authors:
Gloria Valdés

Integr Blood Press Control 2017 28;10:17-23. Epub 2017 Aug 28.

Department of Nephrology, Facultad de Medicina, Pontificia Universidad Católica, Santiago, Chile.

The potent and now longstanding evidence of the association between placentation-related disorders and cardiovascular disease should be translated into clinical practice in order to introduce a preventive approach to future obstetric and cardiovascular diseases. The purpose of this review is to integrate cardiovascular risk/disease and obstetric complications, which are linked by endothelial dysfunction, as windows of opportunity for improving women's health. Questionnaires adaptable to local practices are proposed to incorporate cardiovascular and obstetrical indexes into two stages of a woman's lifetime. Read More

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https://www.dovepress.com/preeclampsia-and-cardiovascular-di
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http://dx.doi.org/10.2147/IBPC.S138383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584914PMC
August 2017
6 Reads

Serum magnesium and calcium in preeclampsia: a comparative study at the Korle-Bu Teaching Hospital, Ghana.

Integr Blood Press Control 2017 16;10:9-15. Epub 2017 Aug 16.

Department of Anaesthesia, Korle-Bu Teaching Hospital, Accra, Ghana.

Background: A large percentage (16% of maternal mortality in developed countries, compared to 9% in developing countries), is due to hypertensive disorders in pregnancy. The etiology of preeclampsia remains unknown, with poorly understood pathophysiology. Magnesium and calcium play an important role in vascular smooth muscle function and therefore a possible role in the development of preeclampsia. Read More

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http://dx.doi.org/10.2147/IBPC.S129106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565255PMC
August 2017
19 Reads
1 Citation

Medication adherence and its associated factors among hypertensive patients attending the Debre Tabor General Hospital, northwest Ethiopia.

Integr Blood Press Control 2017 16;10:1-7. Epub 2017 Jun 16.

Department of Reproductive Health, Institute of Public Health, University of Gondar, Gondar, Ethiopia.

Background: Medication adherence is an important predictor of optimal blood pressure control; hence, it significantly reduces the risk of cardiovascular disease (CVD) and associated deaths. However, studies on medication adherence and its associated factors are scarce. Thus, this study aimed to assess adherence to antihypertensive medications and identify associated factors at Debre Tabor General Hospital, northwest Ethiopia. Read More

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http://dx.doi.org/10.2147/IBPC.S128914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482403PMC
June 2017
54 Reads
2 Citations

Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial.

Integr Blood Press Control 2016 13;9:95-104. Epub 2016 Oct 13.

NIS Labs, Klamath Falls, OR.

Objective: The objective of this study is to evaluate the effects of consumption of nattokinase on hypertension in a North American hypertensive population with associated genetic, dietary, and lifestyle factors. This is in extension of, and contrast to, previous studies on Asian populations.

Materials And Methods: A randomized, double-blind, placebo-controlled, parallel-arm clinical study was performed to evaluate nattokinase (NSK-SD), a fermented soy extract nattō from which vitamin K2 has been removed. Read More

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https://www.dovepress.com/consumption-of-nattokinase-is-asso
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http://dx.doi.org/10.2147/IBPC.S99553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066864PMC
October 2016
13 Reads

Current best practice in the management of hypertensive disorders in pregnancy.

Integr Blood Press Control 2016 27;9:79-94. Epub 2016 Jul 27.

Fetal Medicine Unit, St George's University of London, London, UK.

Preeclampsia is a potentially serious complication of pregnancy with increasing significance worldwide. Preeclampsia is the cause of 9%-26% of global maternal mortality and a significant proportion of preterm delivery, and maternal and neonatal morbidity. Incidence is increasing in keeping with the increase in obesity, maternal age, and women with medical comorbidities entering pregnancy. Read More

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http://dx.doi.org/10.2147/IBPC.S77344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968992PMC
August 2016
7 Reads

Lercanidipine/enalapril combination in the management of obesity-related hypertension.

Authors:
Guido Grassi

Integr Blood Press Control 2016 26;9:69-77. Epub 2016 Apr 26.

Internal Medicine, Department of Health Science, Università Milano-Bicocca, Milano, Italy; Istituto di Ricerche a Carattere Scientifico (IRCCS) Multimedica, Sesto San Giovanni, Milano, Italy.

Obesity-related hypertension represents a condition frequently observed in current clinical practice characterized by a complex pathophysiological background and a very high cardiovascular risk profile, particularly in severely obese individuals. This explains, on the one hand, the difficulty in reducing elevated blood pressure values in this pathological state and, on the other, the need to achieve this goal in a relatively short-time period to prevent the occurrence of fatal and nonfatal cardiovascular events. Both nonpharmacological and pharmacological measures are available in the therapeutic approach for this condition. Read More

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http://dx.doi.org/10.2147/IBPC.S92779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854233PMC
May 2016
6 Reads

Personalized medicine and treatment approaches in hypertension: current perspectives.

Authors:
James Brian Byrd

Integr Blood Press Control 2016 6;9:59-67. Epub 2016 Apr 6.

Division of Cardiovascular Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.

In the US, hypertension affects one in three adults. Current guideline-based treatment of hypertension involves little diagnostic testing. A more personalized approach to the treatment of hypertension might be of use. Read More

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http://dx.doi.org/10.2147/IBPC.S74320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827884PMC
April 2016
4 Reads

Evaluation and treatment of hypertensive crises in children.

Integr Blood Press Control 2016 16;9:49-58. Epub 2016 Mar 16.

Division of Nephrology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Hypertensive crises in children are medical emergencies that must be identified, evaluated, and treated promptly and appropriately to prevent end-organ injury and even death. Treatment in the acute setting typically includes continuous intravenous antihypertensive medications with monitoring in the intensive care unit setting. Medications commonly used to treat severe hypertension have been poorly studied in children. Read More

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http://dx.doi.org/10.2147/IBPC.S50640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803257PMC
April 2016
7 Reads

Effectiveness of continuous positive airway pressure in lowering blood pressure in patients with obstructive sleep apnea: a critical review of the literature.

Integr Blood Press Control 2016 15;9:43-7. Epub 2016 Mar 15.

Hypertension Unit, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil; Hypertension Unit, Renal Division, University of Sao Paulo Medical School, Sao Paulo, Brazil.

Obstructive sleep apnea (OSA) is an extremely common comorbid condition in patients with hypertension, with a prevalence of ~50%. There is growing evidence suggesting that OSA is a secondary cause of hypertension, associated with both poor blood pressure (BP) control and target organ damage in patients with hypertension. The application of continuous positive airway pressure (CPAP) during sleep is the gold standard treatment of moderate- to-severe OSA and very effective in abolishing obstructive respiratory events. Read More

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http://dx.doi.org/10.2147/IBPC.S70402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803254PMC
April 2016
21 Reads

Probiotics and blood pressure: current insights.

Integr Blood Press Control 2016 25;9:33-42. Epub 2016 Feb 25.

Centre for Research and Development, Unique Biotech Limited, Alexandria Knowledge Park, Shamirpet, Hyderabad, India.

Gut microbiota play a significant role in host metabolic processes, and recent metagenomic surveys have revealed that they are involved in host immune modulation and influence host development and physiology (organ development). Initially, probiotics are identified as potential therapeutics to treat gastrointestinal disorders and to revitalize the disturbed gut ecosystem. Currently, studies are exploring the potential for expanded uses of probiotics for improving the health conditions in metabolic disorders that increase the risk of developing cardiovascular diseases such as hypertension. Read More

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http://dx.doi.org/10.2147/IBPC.S73246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772943PMC
March 2016
19 Reads

Chronic resveratrol reverses a mild angiotensin II-induced pressor effect in a rat model.

Integr Blood Press Control 2016 28;9:23-31. Epub 2016 Jan 28.

Department of Physiology, Wayne State School of Medicine, Henry Ford Hospital, Detroit, MI, USA; Department of Internal Medicine, Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI, USA.

Resveratrol is reported to reduce blood pressure in animal models of hypertension, but the mechanisms are unknown. We have shown that resveratrol infusion increases sodium excretion. We hypothesized that chronic ingestion of resveratrol would reduce angiotensin II (Ang II)-induced increases in blood pressure by decreasing oxidative stress and by also decreasing sodium reabsorption through a nitric oxide-dependent mechanism. Read More

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http://dx.doi.org/10.2147/IBPC.S96092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734803PMC
February 2016
8 Reads

The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial.

Integr Blood Press Control 2016 27;9:9-21. Epub 2016 Jan 27.

National Institute of Integrative Medicine, Melbourne, Australia.

Background: Hypertension affects 30% of adults worldwide. Garlic supplements have shown promise in the treatment of uncontrolled hypertension, and the mechanism of action is biologically plausible. Our trial is the first to assess the effect of aged garlic extract on central blood pressure and arterial stiffness, regarded as important risk factors for cardiovascular morbidity. Read More

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https://www.dovepress.com/the-effect-of-aged-garlic-extract-
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http://dx.doi.org/10.2147/IBPC.S93335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734812PMC
February 2016
9 Reads

Clinical use of extended-release oral treprostinil in the treatment of pulmonary arterial hypertension.

Integr Blood Press Control 2016 25;9:1-7. Epub 2016 Jan 25.

Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; UCD Pulmonary Vascular Disease Center, Division of Pulmonary Sciences and Critical Care Medicine and Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

The development of parenteral prostacyclin therapy marked a dramatic breakthrough in the treatment of pulmonary arterial hypertension (PAH). Intravenous (IV) epoprostenol was the first PAH specific therapy and to date, remains the only treatment to demonstrate a mortality benefit. Because of the inherent complexities and risks of treating patients with continuous infusion IV therapy, there is great interest in the development of an oral prostacyclin analog that could mimic the benefits of IV therapy. Read More

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http://dx.doi.org/10.2147/IBPC.S68230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734815PMC
February 2016
9 Reads

Renal denervation for the management of resistant hypertension.

Integr Blood Press Control 2015 3;8:57-69. Epub 2015 Dec 3.

NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK.

Renal sympathetic denervation (RSD) as a therapy for patients with resistant hypertension has attracted great interest. The majority of studies in this field have demonstrated impressive reductions in blood pressure (BP). However, these trials were not randomized or sham-controlled and hence, the findings may have been overinflated due to trial biases. Read More

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http://dx.doi.org/10.2147/IBPC.S65632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675644PMC
December 2015
9 Reads

Comparison between treadmill and bicycle ergometer exercise tests in mild-to-moderate hypertensive Nigerians.

Integr Blood Press Control 2015 11;8:51-5. Epub 2015 Aug 11.

Cardiology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Il-Ife, Osun state, Nigeria.

Background: Comparative cardiovascular responses to treadmill and bicycle ergometer (bike) exercise tests in hypertensive Nigerians are not known. This study compared cardiovascular responses to the two modes of exercise testing in hypertensives using maximal exercise protocols.

Methods: One hundred and ten male subjects with mild-to-moderate hypertension underwent maximal treadmill and bike test one after the other at a single visit in a simple random manner. Read More

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http://dx.doi.org/10.2147/IBPC.S75888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540160PMC
August 2015
17 Reads

Does home blood pressure monitoring improve patient outcomes? A systematic review comparing home and ambulatory blood pressure monitoring on blood pressure control and patient outcomes.

Integr Blood Press Control 2015 3;8:43-9. Epub 2015 Jul 3.

Department of Medicine, John Hopkins School of Medicine, Baltimore, MD, USA.

Objective: Our objective was to compare the clinical effectiveness of home blood pressure monitoring (HBPM) and 24-hour ambulatory blood pressure monitoring (ABPM) on blood pressure (BP) control and patient outcomes.

Design: A systematic review was conducted. We also appraised the methodological quality of studies. Read More

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http://dx.doi.org/10.2147/IBPC.S49205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498728PMC
July 2015
9 Reads

Vasomotor sympathetic outflow in the muscle metaboreflex in low birth weight young adults.

Integr Blood Press Control 2015 27;8:37-42. Epub 2015 May 27.

Department of Physiology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.

A growing body of evidence suggests that low birth weight (LBW) offspring are associated with long-term structural and functional changes in cardiovascular and neuroendocrine systems. We tested the hypothesis that muscle metaboreflex activation produces exaggerated responses in cardiac autonomic tone (represented by heart rate variability ratio) and cutaneous vascular sympathetic tone (represented by plethysmography pulse wave amplitude) in LBW compared to normal birth weight (NBW) young adults. We recruited 23 LBW (18 females and five males) and 23 NBW (14 females and nine males) University of Zimbabwe students with neonatal clinical cards as proof of birth weight at term. Read More

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http://dx.doi.org/10.2147/IBPC.S76382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454205PMC
June 2015
10 Reads

Vitamin D status and hypertension: a review.

Integr Blood Press Control 2015 8;8:13-35. Epub 2015 Apr 8.

Faculty of Medicine, University of Sydney, Sydney, NSW, Australia.

Vitamin D is a steroid prohormone synthesized in the skin following ultraviolet exposure and also achieved through supplemental or dietary intake. While there is strong evidence for its role in maintaining bone and muscle health, there has been recent debate regarding the role of vitamin D deficiency in hypertension based on conflicting epidemiological evidence. Thus, we conducted a scoping systematic literature review and meta-analysis of all observational studies published up to early 2014 in order to map trends in the evidence of this association. Read More

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http://dx.doi.org/10.2147/IBPC.S49958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396645PMC
April 2015
9 Reads

Risk factors and effective management of preeclampsia.

Integr Blood Press Control 2015 3;8:7-12. Epub 2015 Mar 3.

Irish Centre for Fetal and Neonatal Translational Research (INFANT), Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland ; Women's Health Academic Centre, King's Health Partners, St Thomas' Hospital, London, UK.

Preeclampsia, a hypertensive disorder of pregnancy is estimated to complicate 2%-8% of pregnancies and remains a principal cause of maternal and fetal morbidity and mortality. Preeclampsia may present at any gestation but is more commonly encountered in the third trimester. Multiple risk factors have been documented, including: family history, nulliparity, egg donation, diabetes, and obesity. Read More

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http://dx.doi.org/10.2147/IBPC.S50641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354613PMC
March 2015
5 Reads

Nitric oxide dysregulation in the pathogenesis of preeclampsia among Ghanaian women.

Integr Blood Press Control 2015 19;8:1-6. Epub 2015 Feb 19.

Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.

Background: Preeclampsia (PE) is still a disease of theories as the exact cause remains uncertain. Widespread vascular endothelial cell dysfunction is thought to mediate the generalized vasospasm and hypertension characteristic of PE. Altered nitric oxide (NO) production has been associated with the endothelial dysfunction in the pathogenesis of PE but conflicting results have emerged from previous studies. Read More

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http://dx.doi.org/10.2147/IBPC.S68454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340461PMC
March 2015
9 Reads

Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance.

Integr Blood Press Control 2014 9;7:71-82. Epub 2014 Dec 9.

National Institute of Integrative Medicine, Melbourne, VIC, Australia.

Garlic supplements have shown promise in the treatment of uncontrolled hypertension, lowering blood pressure (BP) by about 10 mmHg systolic and 8 mmHg diastolic, similar to standard BP medication. Aged garlic extract, which contains S-allylcysteine as the bioactive sulfur compound, in particular is standardizable and highly tolerable, with little or no known harmful interaction when taken with other BP-reducing or blood-thinning medication. Here we describe biologically plausible mechanisms of garlic's BP-lowering effect. Read More

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http://dx.doi.org/10.2147/IBPC.S51434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266250PMC
December 2014
6 Reads

Clinical utility of fixed-dose combinations in hypertension: evidence for the potential of nebivolol/valsartan.

Integr Blood Press Control 2014 26;7:61-70. Epub 2014 Nov 26.

Division of Surgical Sciences, Wake Forest University, Winston-Salem, NC USA ; Department of Physiology and Pharmacology, Wake Forest University, Winston-Salem, NC USA ; Department of Internal Medicine and Nephrology, Wake Forest University, Winston-Salem, NC, USA.

Despite significant advances in pharmacologic approaches to treat hypertension during the last decades, hypertension- and hypertension-related organ damage are still a high health and economic burden because a large proportion of patients with hypertension do not achieve optimal blood pressure control. There is now general agreement that combination therapy with two or more antihypertensive drugs is required for targeted blood pressure accomplishment and reduction of global cardiovascular risk. The goals of combination therapies are to reduce long-term cardiovascular events by targeting different mechanism underlying hypertension and target organ disease, to block the counterregulatory pathways activated by monotherapies, to improve tolerability and decrease the adverse effects of up-titrated single agents, and to increase persistence and adherence with antihypertensive therapy. Read More

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http://dx.doi.org/10.2147/IBPC.S50954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251532PMC
December 2014
19 Reads

Optimal perioperative management of arterial blood pressure.

Integr Blood Press Control 2014 12;7:49-59. Epub 2014 Sep 12.

Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, University Toulouse III - Paul Sabatier, Toulouse, France.

Perioperative blood pressure management is a key factor of patient care for anesthetists, as perioperative hemodynamic instability is associated with cardiovascular complications. Hypertension is an independent predictive factor of cardiac adverse events in noncardiac surgery. Intraoperative hypotension is one of the most encountered factors associated with death related to anesthesia. Read More

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http://dx.doi.org/10.2147/IBPC.S45292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178624PMC
October 2014
10 Reads

Which thiazide to choose as add-on therapy for hypertension?

Integr Blood Press Control 2014 30;7:35-47. Epub 2014 Jul 30.

Department of Cardiology, Hospital La Paz, Madrid, Spain.

Combined therapy is required in the majority of patients with hypertension to achieve blood pressure (BP) targets. Although different antihypertensive drugs can be combined, not all combinations are equally effective and safe. In this context, the combination of a renin angiotensin system inhibitor with a diuretic, usually a thiazide, particularly hydrochlorothiazide (HCTZ) or thiazide-like diuretics, such as chlorthalidone or indapamide, is recommended. Read More

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http://dx.doi.org/10.2147/IBPC.S40248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142573PMC
August 2014
10 Reads

Aortic stiffness: pathophysiology, clinical implications, and approach to treatment.

Integr Blood Press Control 2014 23;7:29-34. Epub 2014 May 23.

University of Texas Health Science Center, San Antonio, TX, USA.

Aortic stiffness is a hallmark of aging, and classic cardiovascular risk factors play a role in accelerating this process. Current changes in medicine, which focus on preventive care, have led to a growing interest in noninvasive evaluation of aortic stiffness. Aortic stiffness has emerged as a good tool for further risk stratification because it has been linked to increased risk of atherosclerotic heart disease, myocardial infarction, heart failure, and stroke. Read More

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http://dx.doi.org/10.2147/IBPC.S59535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046515PMC
June 2014
9 Reads

Phases in development of an interactive mobile phone-based system to support self-management of hypertension.

Integr Blood Press Control 2014 7;7:19-28. Epub 2014 May 7.

Institute of Health and Care Sciences, University of Gothenburg, Gothenburg, Linköping, Sweden ; Department of Medical and Health Sciences, Linköping University, Linköping ; Centre for Person-Centred Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Hypertension is a significant risk factor for heart disease and stroke worldwide. Effective treatment regimens exist; however, treatment adherence rates are poor (30%-50%). Improving self-management may be a way to increase adherence to treatment. Read More

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http://dx.doi.org/10.2147/IBPC.S59030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046514PMC
June 2014
11 Reads

Recruited renin-containing renal microvascular cells demonstrate the calcium paradox regulatory phenotype.

Integr Blood Press Control 2014 13;7:9-17. Epub 2014 Jan 13.

Department of Internal Medicine, Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI, USA ; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA.

Renin is the critical regulatory enzyme for production of angiotensin (Ang)-II, a potent vasoconstrictor involved in regulating blood pressure and in the pathogenesis of hypertension. Chronic sodium deprivation enhances renin secretion from the kidney, due to recruitment of additional cells from the afferent renal microvasculature to become renin-producing rather than just increasing release from existing juxtaglomerular (JG) cells. JG cells secrete renin inversely proportional to extra- and intracellular calcium, a unique phenomenon characteristic of the JG regulatory phenotype known as the "calcium paradox. Read More

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http://dx.doi.org/10.2147/IBPC.S55684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920457PMC
February 2014
14 Reads

No association between perfluoroalkyl chemicals and hypertension in children.

Integr Blood Press Control 2014 13;7:1-7. Epub 2014 Jan 13.

Department of Epidemiology, School of Public Health, West Virginia University, Morgantown, WV, USA.

Background: Hypertension is a leading cause of cardiovascular disease worldwide. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are perfluoroalkyl chemicals (PFCs) used in the manufacture of common consumer products and detected in the blood of the majority of Americans. Emerging biological data suggest that PFC exposure may have a role in the development of hypertension. Read More

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http://dx.doi.org/10.2147/IBPC.S47660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920456PMC
February 2014
5 Reads

Impact of AT2-receptor stimulation on vascular biology, kidney function, and blood pressure.

Integr Blood Press Control 2013 Nov 22;6:153-61. Epub 2013 Nov 22.

Center for Cardiovascular Research, Institute of Pharmacology, Charité Medical Faculty, Berlin, Germany ; Institute of Molecular Medicine, Department of Cardiovascular and Renal Physiology, University of Southern Denmark, Odense, Denmark.

The angiotensin type 2 receptor (AT2R) and the receptor MAS are receptors within the renin-angiotensin system, which mediate tissue-protective actions such as anti-inflammation, antifibrosis, and antiapoptosis. In recent years, several programs have been launched in order to develop drugs that act as agonists on the AT2R or MAS to take therapeutic advantage of the protective and regenerative properties of these receptors. This review article will focus on recent data obtained in preclinical animal and in vitro models with new AT2R-agonistic molecules (Compound 21 and β-amino acid substituted angiotensin II) and with relevance for blood pressure (BP) regulation or hypertensive end-organ damage. Read More

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http://dx.doi.org/10.2147/IBPC.S34425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873809PMC
November 2013
26 Reads

Management of patients with resistant hypertension: current treatment options.

Integr Blood Press Control 2013 Oct 22;6:139-51. Epub 2013 Oct 22.

Department of Medicine, Hypertension and Vascular Biology Program, University of Alabama at Birmingham, Birmingham, AL, USA.

Resistant hypertension (RHTN) is an increasingly common clinical problem that is often heterogeneous in etiology, risk factors, and comorbidities. It is defined as uncontrolled blood pressure on optimal doses of three antihypertensive agents, ideally one being a diuretic. The definition also includes controlled hypertension with use of four or more antihypertensive agents. Read More

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http://dx.doi.org/10.2147/IBPC.S33984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826290PMC
October 2013
7 Reads

Mineralocorticoid receptor antagonists: emerging roles in cardiovascular medicine.

Authors:
John W Funder

Integr Blood Press Control 2013 Oct 4;6:129-38. Epub 2013 Oct 4.

Prince Henry's Institute, Clayton, Victoria, Australia.

Spironolactone was first developed over 50 years ago as a potent mineralocorticoid receptor (MR) antagonist with undesirable side effects; it was followed a decade ago by eplerenone, which is less potent but much more MR-specific. From a marginal role as a potassium-sparing diuretic, spironolactone was shown to be an extraordinarily effective adjunctive agent in the treatment of progressive heart failure, as was eplerenone in subsequent heart failure trials. Neither acts as an aldosterone antagonist in the heart as the cardiac MR are occupied by cortisol, which becomes an aldosterone mimic in conditions of tissue damage. Read More

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http://dx.doi.org/10.2147/IBPC.S13783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796852PMC
October 2013
5 Reads

Treating resistant hypertension: role of renal denervation.

Integr Blood Press Control 2013 Sep 11;6:119-28. Epub 2013 Sep 11.

Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, University Hospital of Saarland, Homburg, Saarland, Germany.

Arterial hypertension is the most prevalent risk factor associated with increased cardiovascular morbidity and mortality. Although pharmacological treatment is generally well tolerated, 5%-20% of patients with hypertension are resistant to medical therapy, which is defined as blood pressure above goal (>140/90 mmHg in general; >130-139/80-85 mmHg in patients with diabetes mellitus; >130/80 mmHg in patients with chronic kidney disease) despite treatment with ≥3 antihypertensive drugs of different classes, including a diuretic, at optimal doses. These patients are at significantly higher risk for cardiovascular events, in particular stroke, myocardial infarction, and heart failure, as compared with patients with nonresistant hypertension. Read More

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http://dx.doi.org/10.2147/IBPC.S33958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791632PMC
September 2013
15 Reads

Prevalence of hypertension and its risk factors in southwest Ethiopia: a hospital-based cross-sectional survey.

Integr Blood Press Control 2013 31;6:111-7. Epub 2013 Jul 31.

Department of Internal Medicine, Jimma University, Jimma, Ethiopia.

Background: Hypertension is a common medical condition worldwide. It is an important public health challenge because of the associated morbidity, mortality, and the cost to the society. The objective of this study was to determine the prevalence of hypertension and its risk factors among attendants of adult outpatient departments at Jimma University Specialized Hospital in southwest Ethiopia. Read More

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http://dx.doi.org/10.2147/IBPC.S47298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753877PMC
August 2013
7 Reads
17 Citations

Current perspectives on treatment of hypertensive patients with chronic obstructive pulmonary disease.

Integr Blood Press Control 2013 9;6:101-9. Epub 2013 Jul 9.

Division of Pulmonary, Critical Care and Sleep.

Systemic hypertension and chronic obstructive pulmonary disease (COPD) frequently coexist in the same patient, especially in the elderly. Today, a wide variety of antihypertensive drugs with different mechanisms of action are available to the prescribing physician. In addition, combination drugs for hypertension are becoming increasingly popular. Read More

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http://dx.doi.org/10.2147/IBPC.S33982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724277PMC
July 2013
10 Reads

The TRINITY Study: distribution of systolic blood pressure reductions.

Integr Blood Press Control 2013 12;6:89-99. Epub 2013 Jul 12.

Cedar-Crosse Research Center and Rush Medical College, Chicago, IL, USA.

Background: Elevated systolic blood pressure is more difficult to control than elevated diastolic blood pressure. The objective of this prespecified analysis of the Triple Therapy with Olmesartan Medoxomil, Amlodipine, and Hydrochlorothiazide in Hypertensive Patients Study (TRINITY) was to compare the efficacy of olmesartan medoxomil (OM) 40 mg, amlodipine besylate (AML) 10 mg, and hydrochlorothiazide (HCTZ) 25 mg triple-combination treatment with the component dual-combination treatments in reducing elevated seated systolic blood pressure (SeSBP).

Methods: The 12-week TRINITY study randomized participants to either one of the three component dual-combination treatments (OM 40 mg/AML 10 mg, OM 40 mg/HCTZ 25 mg, or AML 10 mg/HCTZ 25 mg) or the triple-combination treatment. Read More

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http://dx.doi.org/10.2147/IBPC.S45450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724275PMC
July 2013
6 Reads

A review of the gastrointestinal therapeutic system (GITS) formulation and its effectiveness in the delivery of antihypertensive drug treatment (focus on nifedipine GITS).

Integr Blood Press Control 2013 25;6:79-87. Epub 2013 Jun 25.

Medicine and Therapeutics, University of Glasgow, The Western Infirmary, Glasgow, United Kingdom.

Hypertension treatment guidelines do not discriminate within drug classes and, furthermore, do not consider whether or not all of the formulations of any given drug licensed for once-daily administration can be considered to be therapeutically interchangeable. This article focuses on this issue with respect to nifedipine and the development of the gastrointestinal therapeutic system (GITS) formulation. Nifedipine GITS is regarded as the gold standard once-daily formulation of nifedipine and, as such, it is anticipated that alternative formulations will be therapeutically equivalent to nifedipine GITS. Read More

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http://dx.doi.org/10.2147/IBPC.S34803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724274PMC
July 2013
13 Reads

Current perspectives on combination therapy in the management of hypertension.

Integr Blood Press Control 2013 17;6:69-78. Epub 2013 Jun 17.

American University of Beirut, Department of Internal Medicine, Division of Nephrology and Hypertension, Beirut, Lebanon.

Hypertension (HTN) is a worldwide health problem and a major preventable risk factor for cardiovascular (CV) events. Achieving an optimal blood pressure (BP) target for patients with HTN will often require more than one BP-lowering drug. Combination therapy is not only needed, but also confers many advantages such as better efficacy and a better tolerability. Read More

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http://dx.doi.org/10.2147/IBPC.S33985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699293PMC
July 2013
8 Reads
6 Citations