247,931 results match your criteria Integrated Blood Pressure Control [Journal]


Therapeutic Hypothermia in Brazil: A MultiProfessional National Survey.

Am J Perinatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, Neonatal Division, McGill University Health Center, Montreal, Quebec, Canada.

Objective:  To determine the rate of therapeutic hypothermia (TH) use, current practices, and long-term follow-up.

Study Design:  Prospective cross-sectional national survey with 19 questions related to the assessment of hypoxic-ischemic encephalopathy (HIE) and TH practices. An online questionnaire was made available to health care professionals working in neonatal care in Brazil. Read More

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December 2018

An update on Drug Repurposing: Re-written saga of the drug's fate.

Biomed Pharmacother 2018 Dec 12;110:700-716. Epub 2018 Dec 12.

Pharamacological Modelling and Simulation Centre, M.S.Ramaiah University of Applied Sciences, Bangalore, Karnataka, India; Department of Pharmacy Practice, Faculty of Pharmacy, M.S.Ramaiah University of Applied Sciences, Bangalore, Karnataka, India.

Drug repurposing is an unconventional drug discovery approach to explore new therapeutic benefits of existing, shelved and the drugs in clinical trials. This approach is currently emerging to overcome the bottleneck constraints faced during traditional drug discovery in grounds of financial support, timeline and resources. In this direction, several efforts were made for the construction of stratagems based on bioinformatics and computational tools to intensify the repurposing process off-late. Read More

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December 2018

A decade of Nucleic Acid Programmable Protein Arrays (NAPPA) availability: News, actors, progress, prospects and access.

J Proteomics 2018 Dec 12. Epub 2018 Dec 12.

Proteomics Unit, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain; Department of Medicine and General Cytometry Service-Nucleus, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain. Electronic address:

Understanding the dynamic of the proteome is a critical challenge because it requires high sensitive methodologies in high-throughput formats in order to decipher its modifications and complexity. While molecular biology provides relevant information about cell physiology that may be reflected in post-translational changes, High-Throughput (HT) experimental proteomic techniques are essential to provide valuable functional information of the proteins, peptides and the interconnections between them. Hence, many methodological developments and innovations have been reported during the last decade. Read More

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December 2018

Novel predators and anthropogenic disturbance influence spatio-temporal distribution of forest antelope species.

Behav Processes 2018 Dec 12. Epub 2018 Dec 12.

School of Life Sciences, University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg 3209, South Africa. Electronic address:

Understanding the effects of anthropogenic disturbance on species' behaviour is crucial for conservation planning, considering the extent of habitat loss. We investigated the influence of anthropogenic disturbances including agriculture, urbanisation, protected areas, and the presence of novel predators, on the temporal and spatial behaviour of sympatric forest antelope (Tragelaphus scriptus, Philantomba monticola, Sylvicapra grimmia, and Cephalophus natalensis) in an anthropogenic matrix containing forest fragments in the Indian Ocean Coastal Belt of South Africa. We integrated land-use types with camera-trap data and compared activity patterns using circular statistics and occupancy modelling. Read More

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December 2018

Integrational analysis of miRNAs data sets as a plausible missing linker between Epstein-Barr virus and vitamin D in relapsing remitting MS patients.

Gene 2018 Dec 12. Epub 2018 Dec 12.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Given the multifactorial state of autoimmune complex diseases such as multiple sclerosis (MS), it is not clear if different risk factors act jointly or independently. Despite intensive studies investigating multi aspects of MS risk factors, findings with regards to potential biomarkers that may link these risk factors remained largely inconclusive. System biology or data integration utilizes different validated datasets to extract meaningful information and map the plausible biological pathways and networks. Read More

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December 2018

Characterization of HPV integration, viral gene expression and E6E7 alternative transcripts by RNA-Seq: A descriptive study in invasive cervical cancer.

Genomics 2018 Dec 12. Epub 2018 Dec 12.

Genetics Program, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil. Electronic address:

Scarce data are available on the expression of Papillomavirus genome and the frequency of alternatively spliced E6/E7 mRNAs in invasive cervical cancer. We carried out a comprehensive characterization of HPV expression by RNA-Seq analysis in 22 invasive cervical cancer with HPV16 or HPV18, characterizing the presence of integrated/episomal viral DNA, the integration sites in human genome and the proportion of alternative splicing products of E6 and E7 genes. The expression patterns suggested the presence of episomal and/or integrated viral DNA, with integration detected in most tumors, frequently occurring within human genes in HPV18+ and in intergenic regions in HPV16+ tumors. Read More

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December 2018

Women's perspectives about cannabis use during pregnancy and the postpartum period: An integrative review.

Prev Med 2018 Dec 12. Epub 2018 Dec 12.

University of British Columbia, Vancouver, BC, Canada.

Cannabis is the most commonly used illicit drug among general and pregnant populations. Despite recommendations to abstain from cannabis use, its use is increasing during the perinatal period. In this integrative review, we aim to understand women's perspectives about the health aspects of perinatal cannabis use. Read More

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December 2018
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Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand-independent functions.

Toxicol Appl Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Department of Environmental and Molecular Toxicology, Oregon State University, 1007 Agriculture & Life Sciences Building, Corvallis, OR 97331; USA; LS Pharma, 884 Park St., Lebanon, OR 97355; USA.

Alternative splicing modulates gene function by creating splice variants with alternate functions or non-coding RNA activity. Naturally occurring variants of nuclear receptor (NR) genes with dominant negative or gain-of-function phenotypes have been documented, but their cellular roles, regulation, and responsiveness to environmental stress or disease remain unevaluated. Informed by observations that class I androgen and estrogen receptor variants display ligand-independent signaling in human cancer tissues, we questioned whether the function of class II NRs, like the vitamin D receptor (VDR), would also respond to alternative splicing regulation. Read More

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December 2018

Novel multifunctional nanocomposite for root caries restorations to inhibit periodontitis-related pathogens.

J Dent 2018 Dec 12. Epub 2018 Dec 12.

Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

Objectives: The objectives of this study were to: (1) develop a novel multifunctional composite with nanoparticles of silver (NAg), 2-methacryloyloxyethyl phosphorylcholine (MPC), dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP); and (2) investigate biofilm-inhibition via the multifunctional nanocomposite against three species of periodontal pathogens for the first time.

Methods: The multifunctional nanocomposite was fabricated by incorporating NAg, MPC, DMAHDM and NACP into the resin consisting of pyromellitic glycerol dimethacrylate (PMDGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA). Three species (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum) were tested for metabolic activity (MTT), live/dead staining, polysaccharide production and colony-forming units (CFU) of biofilms grown on resins. Read More

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December 2018

A comparative effectiveness study of degludec and insulin glargine 300U/mL in insulin-naïve patients with type 2 diabetes.

Diabetes Obes Metab 2018 Dec 15. Epub 2018 Dec 15.

Clinical Research, Endocrine and Metabolic Consultants, Rockville, MD, USA.

Aims: To compare the real-world effectiveness of insulin degludec (degludec) and glargine 300 units/mL (glargine U300) in insulin-naïve adult patients with type 2 diabetes in routine US clinical practice.

Materials And Methods: CONFIRM is a non-interventional comparative effectiveness study following US patients across the continuum of care, through electronic medical records from multiple health systems and integrated delivery networks. Propensity-score matching controlled for confounding. Read More

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December 2018

Transforming the experience of aortic valve disease in older patients: a qualitative study.

J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiothoracic Surgery, the Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Aim And Objectives: To explore patients' lived experiences of daily life and coping with recovery after Transcatheter aortic valve implantation (TAVI).

Background: TAVI is increasingly used to treat older patients with severe aortic stenosis with high surgical risk. This novel treatment has been shown to be effective in relieving symptoms, improving survival and prognosis, but its impact on patients' daily life has been sparsely explored. Read More

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December 2018

A population pharmacokinetic model to predict the individual starting dose of tacrolimus in adult renal transplant recipients.

Br J Clin Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Aims: The aims of this study were to describe the pharmacokinetics of tacrolimus immediately after kidney transplantation, and to develop a clinical tool for selecting the best starting dose for each patient.

Methods: Data on tacrolimus exposure were collected for the first three months following renal transplantation. A population pharmacokinetic analysis was conducted using nonlinear mixed-effects modeling (NONMEM). Read More

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December 2018

Physician referral to a psychologist: Testing alternative behavioral healthcare seeking models.

J Clin Psychol 2018 Dec 15. Epub 2018 Dec 15.

Psychology Department, Virginia Commonwealth University, Richmond, Virginia.

Objective: Primary care physicians (PCPs) often refer patients to psychological services, but help-seeking factors in the context of behavioral healthcare referral are understudied. This study examined perceptions of seeking psychological help for depression by comparing alternative structural equation models derived from the Theory of Reasoned Action (TRA).

Method: Internet survey participants (N = 685 US adults, 77% female, M  = 45) imagined themselves in a vignette scenario in which they are experiencing depression symptoms and encouraged by a PCP to see a psychologist. Read More

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December 2018

Process Analytical Technology Implementation for Protein Refolding: GCSF as a Case Study.

Biotechnol Bioeng 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, India.

Process analytical technology is gaining interest in the biopharmaceutical industry as a means to enable consistency in processing and thereby in product quality via process control. Protein refolding is known to be significantly impacted by critical process parameters and feed material attributes including composition and pH of the solubilization and refolding buffers. Hence, in order to achieve robust process control and product quality, these attributes and parameters need to be monitored. Read More

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December 2018

Environmental performance of ordinary and new generation concrete structures-a comparative analysis.

Environ Sci Pollut Res Int 2018 Dec 14. Epub 2018 Dec 14.

AGH University of Science and Technology, Krakow, Poland.

The development of concrete technology results in a new generation of cement-based concrete such as high-performance concrete, self-compacting concrete and high-performance, self-compacting concrete. These concretes are characterised by better parameters not only in terms of strength and durability but also rheology of the mixtures. Obtaining such properties requires the adoption of a different composition and proportion of ingredients than ordinary concrete. Read More

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December 2018

Understanding the Connections Between Dogs, Health and Inuit Through a Mixed-Methods Study.

Ecohealth 2018 Dec 14. Epub 2018 Dec 14.

Groupe de recherche en épidémiologie des zoonoses et santé publique, Université de Montréal, 3200 Sicotte, Saint-Hyacinthe, QC, J2S 7C6, Canada.

Dogs have been an integral part of the Inuit social and cultural environment for generations, but their presence also generates public health risks such as bites and exposure to zoonotic diseases such as rabies. In Nunavik, Canada, some prevention and control interventions targeting dogs have been implemented but have not demonstrated their effectiveness in a long-term sustainable perspective. This study was conducted in one Inuit community of Nunavik and used mixed methods to get a better understanding of factors that affect human and dog health, dog-related risks for humans and perceptions of dogs in Inuit communities using an interdisciplinary perspective in line with the Ecohealth approach. Read More

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December 2018

Chaos-embedded particle swarm optimization approach for protein-ligand docking and virtual screening.

J Cheminform 2018 Dec 14;10(1):62. Epub 2018 Dec 14.

Department of Computer and Information Science, University of Macau, Avenida da Universidade, Taipa, Macau, China.

Background: Protein-ligand docking programs are routinely used in structure-based drug design to find the optimal binding pose of a ligand in the protein's active site. These programs are also used to identify potential drug candidates by ranking large sets of compounds. As more accurate and efficient docking programs are always desirable, constant efforts focus on developing better docking algorithms or improving the scoring function. Read More

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December 2018

Magnetic-core@dual-functional-shell nanocomposites with peroxidase mimicking properties for use in colorimetric and electrochemical sensing of hydrogen peroxide.

Mikrochim Acta 2018 Dec 14;186(1):20. Epub 2018 Dec 14.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.

A self-sacrificing catalytic method is described for the preparation of magnetic core/dual-functional-shell nanocomposites composed of magnetite, gold and Prussian Blue (type FeO@Au-PB). Two reaction pathways are integrated. The first involves chemical dissolution of FeO (the self-sacrificing step) by acid to release ferrous ions which then reacts with hexacyanoferrate(IV) to generate PB in the proximity of the magntic nanoparticles (MNPs). Read More

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December 2018

Galvanic displacement-induced codeposition of reduced-graphene-oxide/silver on alloy fibers for non-destructive SPME@SERS analysis of antibiotics.

Mikrochim Acta 2018 Dec 14;186(1):19. Epub 2018 Dec 14.

Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan, Shandong, 250100, People's Republic of China.

This work describes the integration of solid-phase microextraction (SPME) and surface-enhanced Raman spectroscopy (SERS) by codeposition of a hybrid consisting of reduced graphene oxide and silver on silver-copper alloy fibers. The morphology and structure of the coating were characterized by a variety of microscopic and spectroscopic techniques that confirmed the hybrid structure of the material. A galvanic-displacement-induced process is assumed to be involved during the codeposition of the hybrid coating on the alloy. Read More

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December 2018

[Prospects and constraints of nursing home-based integrated adult day care : Viewpoints of experts].

Z Gerontol Geriatr 2018 Dec 14. Epub 2018 Dec 14.

AG6 Versorgungsforschung & Pflegewissenschaft, Fakultät für Gesundheitswissenschaften, Universität Bielefeld, Universitätsstraße 25, 33615, Bielefeld, Deutschland.

Background: Even when they are in need of care, old people prefer to stay in their community. An appropriate design of nonresidential and residential care services close to people's home is crucial for supporting them. In the model project "Pflege stationär-Weiterdenken!" (Nursing home care-think ahead!) nursing homes offer extended services to old people in the community. Read More

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December 2018

The first application of quantitative H NMR spectroscopy as a simple and fast method of identification and quantification of microplastic particles (PE, PET, and PS).

Anal Bioanal Chem 2018 Dec 14. Epub 2018 Dec 14.

Institute of Integrated Natural Sciences, University Koblenz-Landau, Universitätsstr. 1, 56070, Koblenz, Germany.

Microplastic (0.001-5 mm) is a serious problem for the environment and is globally distributed. It has been detected in marine and limnic waters as well as in organisms. Read More

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December 2018

Drug and disease signature integration identifies synergistic combinations in glioblastoma.

Nat Commun 2018 Dec 14;9(1):5315. Epub 2018 Dec 14.

Center for Therapeutic Innovation, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1120 NW 14th St, Miami, FL, 33136, USA.

Glioblastoma (GBM) is the most common primary adult brain tumor. Despite extensive efforts, the median survival for GBM patients is approximately 14 months. GBM therapy could benefit greatly from patient-specific targeted therapies that maximize treatment efficacy. Read More

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December 2018

Spike-timing-dependent plasticity learning of coincidence detection with passively integrated memristive circuits.

Nat Commun 2018 Dec 14;9(1):5311. Epub 2018 Dec 14.

Electrical and Computer Engineering Department, UC Santa Barbara, Santa Barbara, CA, 93106-9560, USA.

Spiking neural networks, the most realistic artificial representation of biological nervous systems, are promising due to their inherent local training rules that enable low-overhead online learning, and energy-efficient information encoding. Their downside is more demanding functionality of the artificial synapses, notably including spike-timing-dependent plasticity, which makes their compact efficient hardware implementation challenging with conventional device technologies. Recent work showed that memristors are excellent candidates for artificial synapses, although reports of even simple neuromorphic systems are still very rare. Read More

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December 2018

Multiple biomarkers covering distinct pathways for predicting outcomes after ischemic stroke.

Neurology 2018 Dec 14. Epub 2018 Dec 14.

From the Department of Epidemiology (C.Z., Z.Z., A.W., Tan Xu, X.B., H.P., J.Y., L.H., Tian Xu, Y.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., J.C., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Preventive Medicine (L.H.), Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China; Department of Medicine (J.C., J.H.), Tulane University School of Medicine, New Orleans, LA; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Nantong; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology; Department of Neurology (J.W.), Yutian County Hospital, Tangshan; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Taian; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Tongliao; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.

Objective: To study the prognostic significance of multiple novel biomarkers in combination after ischemic stroke.

Methods: We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke, and 12 informative biomarkers were measured. The primary outcome was the combination of death and major disability (modified Rankin Scale score ≥3) at 3 months after ischemic stroke, and secondary outcomes included major disability, death, and vascular events. Read More

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December 2018

Definition of whole person care in general practice in the English language literature: a systematic review.

BMJ Open 2018 Dec 14;8(12):e023758. Epub 2018 Dec 14.

Psycho-Oncology Co-operative Research Group, Sydney Health Ethics, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.

Objectives: The importance of 'whole person' or 'holistic' care is widely recognised, particularly with an increasing prevalence of chronic multimorbidity internationally. This approach to care is a defining feature of general practice. However, its precise meaning remains ambiguous. Read More

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December 2018

Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?

Ann Rheum Dis 2018 Dec 14. Epub 2018 Dec 14.

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK

Objectives: Controlled immune responses rely on integrated crosstalk between cells and their microenvironment. We investigated whether targeting proinflammatory signals from the extracellular matrix that persist during pathological inflammation provides a viable strategy to treat rheumatoid arthritis (RA).

Methods: Monoclonal antibodies recognising the fibrinogen-like globe (FBG) of tenascin-C were generated by phage display. Read More

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December 2018

Aging of Antiviral CD8 Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing.

J Immunol 2018 Dec 14. Epub 2018 Dec 14.

Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045;

Aging of established antiviral T cell memory can foster a series of progressive adaptations that paradoxically improve rather than compromise protective CD8 T cell immunity. We now provide evidence that this gradual evolution, the pace of which is contingent on the precise context of the primary response, also impinges on the molecular mechanisms that regulate CD8 memory T cell (T) homeostasis. Over time, CD8 T generated in the wake of an acute infection with the natural murine pathogen lymphocytic choriomeningitis virus become more resistant to apoptosis and acquire enhanced cytokine responsiveness without adjusting their homeostatic proliferation rates; concurrent metabolic adaptations promote increased CD8 T quiescence and fitness but also impart the reacquisition of a partial effector-like metabolic profile; and a gradual redistribution of aging CD8 T from blood and nonlymphoid tissues to lymphatic organs results in CD8 T accumulations in bone marrow, splenic white pulp, and, particularly, lymph nodes. Read More

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December 2018

Development of an Electronic Data Collection System to Support a Large-Scale HIV Behavioral Intervention Trial: Protocol for an Electronic Data Collection System.

JMIR Res Protoc 2018 Dec 14;7(12):e10777. Epub 2018 Dec 14.

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States.

Background: Advancing technology has increased functionality and permitted more complex study designs for behavioral interventions. Investigators need to keep pace with these technological advances for electronic data capture (EDC) systems to be appropriately executed and utilized at full capacity in research settings. Mobile technology allows EDC systems to collect near real-time data from study participants, deliver intervention directly to participants' mobile devices, monitor staff activity, and facilitate near real-time decision making during study implementation. Read More

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December 2018

Electron injection from mitochondrial transcription factor A to DNA associated with thymine dimer photo repair.

Bioorg Med Chem 2018 Nov 29. Epub 2018 Nov 29.

Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto 606-8502, Japan; Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

Electron transfer through π-stacked arrays of double-stranded DNA contributes to the redox chemistry of bases, including guanine oxidation and thymine-thymine dimer repair by photolyase. 5-Bromouracil is an attractive photoreactive thymine analogue that can be used to investigate electron transfer in DNA, and is a useful probe for protein-DNA interaction analysis. In the present study using U we found that UV irradiation facilitated electron injection from mitochondrial transcription factor A into DNA. Read More

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November 2018

Individual, social, and physical environmental factors related to changes in walking and cycling for transport among older adults: A longitudinal study.

Health Place 2018 Dec 11. Epub 2018 Dec 11.

Research Foundation Flanders (FWO), Belgium; Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, 4k3, B-9000 Ghent, Belgium.

To date, no longitudinal studies examined the change in walking and cycling for transport as distinct outcomes over time and investigated the predictors of those changes. Therefore, this present study examined the change in odds of engagement in walking and cycling for transport as distinct outcomes among Belgian older adults over a three-year follow-up period, and examined factors (i.e. Read More

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December 2018

Integrated Care Management of Patients With Atrial Fibrillation and Risk of Cardiovascular Events: The ABC (Atrial fibrillation Better Care) Pathway in the ATHERO-AF Study Cohort.

Mayo Clin Proc 2018 Dec 11. Epub 2018 Dec 11.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Denmark. Electronic address:

Objective: To investigate the impact on cardiovascular events (CVEs) in a real-world population of patients with atrial fibrillation (AF) by implementing the Atrial fibrillation Better Care (ABC: A, Avoid stroke with anticoagulation; B, better symptom management; C, Cardiovascular and comorbidity risk management) pathway.

Patients And Methods: This prospective single-center cohort study included 907 consecutive patients with nonvalvular AF on vitamin K antagonists from February 2008 to December 2016. The A, B, and C groups were defined as follows: "A" by a Time in Therapeutic Range ≥65%; "B" by a European Heart Rhythm Association (EHRA) symptom scale I-II, and "C" as optimized cardiovascular comorbidity management. Read More

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December 2018

Healing the hurt amid the drug war: Narratives of young urban poor Filipinos in recovering families with parental drug use.

Int J Drug Policy 2018 Dec 11. Epub 2018 Dec 11.

Ateneo de Manila University, Philippines. Electronic address:

Background: This qualitative study explores the stories of young urban poor Filipino family members living with recovering parental drug users who turn themselves in to local authorities and completed theKatatagan Kontra Droga sa Komunidad (KKDK). This is a community-based rehabilitation program during the Philippine government's anti-illegal drugs campaign.

Methods: Young urban poor family members living with parental drug use were interviewed (n = 13) and asked to narrate their experiences of parental drug use, surrender, and recovery. Read More

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December 2018

Translational research on clinically failed zirconia implants.

Dent Mater 2018 Dec 11. Epub 2018 Dec 11.

HEPIA, University of Applied Sciences - Western Switzerland (HES-SO), Geneva, Switzerland. Electronic address:

Objectives: To provide fractographic analysis of clinically fractured zirconia implants recovered with their cemented crown. To calculate bending moments, corresponding stress and crack onset location on the implant's fracture surface using a mathematical model integrating spatial coordinates of the crown-implant part and occlusal loading obtained from 2D and 3D images.

Methods: 15 fractured zirconia implants parts (11 posterior and 4 anterior) with their all- ceramic crowns still cemented on it were recovered. Read More

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December 2018

Attitudes and beliefs about musculoskeletal pain and its association with pain neuroscience knowledge among physiotherapy students in Israel.

Isr J Health Policy Res 2018 Dec 15;7(1):67. Epub 2018 Dec 15.

Department of Physical Therapy, Faculty of Health Sciences Ariel University, 40700, Ariel, Israel.

Background: Physiotherapy has a vital role in helping patients manage and overcome musculoskeletal pain. Healthcare providers' beliefs about pain are associated with the beliefs of their patients. This study evaluated the attitudes, beliefs and level of pain neuroscience knowledge among Israeli Bachelor-level physiotherapy students. Read More

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December 2018

A Brief History of Oral and Maxillofacial Pathology in Iran.

Arch Iran Med 2018 Nov 1;21(11):551-555. Epub 2018 Nov 1.

Academy of Medical Sciences Islamic Republic of Iran, Tehran, Iran.

This is a brief look at the establishment and development of oral and maxillofacial pathology in Iran. The program of the oral and maxillofacial pathology at first was integrated into the curriculum of the Dental School of Tehran University in 1960. The Iranian Society of Oral and Maxillofacial Pathologists was officially founded in 1999. Read More

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November 2018

Integration of Satellite Data with High Resolution Ratio: Improvement of Spectral Quality with Preserving Spatial Details.

Sensors (Basel) 2018 Dec 13;18(12). Epub 2018 Dec 13.

Department of Remote Sensing, Photogrammetry and Imagery Intelligence, Institute of Geodesy, Faculty of Civil Engineering and Geodesy, Military University of Technology, 01-476 Warszawa, Poland.

Commonly used image fusion techniques generally produce good results for images obtained from the same sensor, with a standard ratio of spatial resolution (1:4). However, an atypical high ratio of resolution reduces the effectiveness of fusion methods resulting in a decrease in the spectral or spatial quality of the sharpened image. An important issue is the development of a method that allows for maintaining simultaneous high spatial and spectral quality. Read More

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December 2018

A Simple Graphene NH₃ Gas Sensor via Laser Direct Writing.

Sensors (Basel) 2018 Dec 13;18(12). Epub 2018 Dec 13.

Department of Mechanical and Electrical Engineering, Xiamen University, Xiamen 361005, China.

Ammonia gas sensors are very essential in many industries and everyday life. However, their complicated fabrication process, severe environmental fabrication requirements and desorption of residual ammonia molecules result in high cost and hinder their market acceptance. Here, laser direct writing is used to fabricate three parallel porous 3D graphene lines on a polyimide (PI) tape to simply construct an ammonia gas sensor. Read More

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December 2018

Mitophagy protects SH-SY5Y neuroblastoma cells against the TNFα-induced inflammatory injury: Involvement of microRNA-145 and Bnip3.

Biomed Pharmacother 2019 Jan 5;109:957-968. Epub 2018 Nov 5.

Department of Stomatology, Chinese PLA General Hospital, Beijing, 100853, China. Electronic address:

Inflammatory response is involved in the development of facial neuritis. The aim of our study is to explore the role of mitophagy in facial nerve damage induced by tumor necrosis factor α (TNFα). Our results indicated that TNFα induced SH-SY5Y cell apoptosis in a dose-dependent manner. Read More

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January 2019

Effect of compound sophorae decoction on dextran sodium sulfate (DSS)-induced colitis in mice by regulating Th17/Treg cell balance.

Biomed Pharmacother 2019 Jan 30;109:2396-2408. Epub 2018 Nov 30.

Department of Cardiology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China.

Objective: Compound sophorae decoction, a Chinese medicinal formulae composed of six Chinese herbs, is effective for the clinical treatment of ulcerative colitis (UC). Some of its effective monomers had been proven to have suppressive effect on UC models. The aim of this study is to further explore the mechanism whether compound sophorae decoction ameliorates dextran sodium sulfate (DSS)-induced mice colitis by regulating the balance between T helper (Th) 17 and regulatory T (Treg) cells. Read More

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January 2019

Rosmarinic acid reduces the resistance of gastric carcinoma cells to 5-fluorouracil by downregulating FOXO4-targeting miR-6785-5p.

Biomed Pharmacother 2019 Jan 30;109:2327-2334. Epub 2018 Nov 30.

Department of Medicine, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiang Su, 210000. Electronic address:

Objective: Chemoresistance has been a major problem in cancer chemotherapy. The present study aimed to investigate the effect of Rosmarinic acid (RA) on chemoresistance to 5-Fu and its molecular mechanism in gastric carcinoma.

Methods: CCK8 cell proliferation and apoptosis assay were used to evaluate the effect of RA on chemoresistance to 5-Fu in GC cells. Read More

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January 2019
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Pretreated fucoidan confers neuroprotection against transient global cerebral ischemic injury in the gerbil hippocampal CA1 area via reducing of glial cell activation and oxidative stress.

Biomed Pharmacother 2019 Jan 20;109:1718-1727. Epub 2018 Nov 20.

Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon, 24252, Republic of Korea. Electronic address:

Fucoidan is a sulfated polysaccharide derived from brown algae and possesses various beneficial activities, including antioxidant property. Previous studies have shown that fucoidan displays protective effect against ischemia-reperfusion injury in some organs. However, few studies have been reported regarding the protective effect of fucoidan against transient cerebral ischemic insults and its related mechanisms. Read More

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January 2019

Magnetofluorescent nanohybrid comprising polyglycerol grafted carbon dots and iron oxides: Colloidal synthesis and applications in cellular imaging and magnetically enhanced drug delivery.

Colloids Surf B Biointerfaces 2019 Jan 27;173:842-850. Epub 2018 Oct 27.

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China. Electronic address:

Multifunctional nanohybrids are attracting increasing attention for potential biomedical applications such as bioimaging and drug delivery due to their combined advantages of individual components. However, challenges in the improvement of their synthesis and colloidal stability to facilitate practical biomedical applications still remain. In this work, we report an efficient synthetic approach to fabricate magnetofluorescent nanohybrid (IO-PG-CD) comprising fluorescent carbon dots (CDs) and magnetic iron oxide nanoparticles (IOs) through polyglycerol (PG) mediated covalent linkage in aqueous media. Read More

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January 2019

Integrated Analysis by GC(RI), GC-MS and 1C NMR of Fortunella japonica Leaf Volatiles Obtained by Hydrodistillation, Microwave- assisted Hydrodistillation and Hydrolate Extraction.

Nat Prod Commun 2017 Mar;12(3):431-434

The chemical composition of the essential oil (EO), microwave extract (ME) and hydrolate extract (HE) from the same batch of leaves of Fortunella japonica, was investigated: by combination of chromatographic (GC, CC) and spectroscopic techniques (GC-MS, 13C NMR). F. japonica essential oil and extracts are complex mixtures of 28-60 compounds being mainly oxygenated sesquiterpenes. Read More

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Sublethal and Hormesis Effects of Clothianidin on the Black Cutworm (Lepidoptera: Noctuidae).

J Econ Entomol 2018 Dec;111(6):2809-2816

College of Plant Protection, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong, P.R. China.

The black cutworm, Agrotis ipsilon (Hufnagel) (Lepidoptera: Noctuidae), has been considered a major insect pest in China that causes damage to corn at the seeding stage. The present study measured the lethal and sublethal effects of the neonicotinoid insecticide clothianidin on A. ipsilon. Read More

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December 2018

The burden and epidemiology of polyparasitism among rural communities in Kano State, Nigeria.

Trans R Soc Trop Med Hyg 2018 Dec 14. Epub 2018 Dec 14.

Department of Parasitology, Faculty of Medicine, University of Malaya,Kuala Lumpur, Malaysia.

Background: Parasitic infections constitute a major public health problem worldwide, particularly among underprivileged communities in developing countries including Nigeria. The present study aimed to determine the epidemiology of polyparasitism (multiple parasitic infections) among rural communities in Kano State, North Central Nigeria.

Methods: A total of 551 individuals were screened for the presence of intestinal, urogenital and blood parasites by using different diagnostic techniques. Read More

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December 2018

A decision tree-based integrated testing strategy for tailor-made carcinogenicity evaluation of test substances using genotoxicity test results and chemical spaces.

Mutagenesis 2018 Dec 14. Epub 2018 Dec 14.

R&D, Safety Science Research, Kao Corporation, Ichikai-Machi, Haga-Gun, Tochigi, Japan.

Genotoxicity evaluation has been widely used to estimate the carcinogenicity of test substances during safety evaluation. However, the latest strategies using genotoxicity tests give more weight to sensitivity; therefore, their accuracy has been very low. For precise carcinogenicity evaluation, we attempted to establish an integrated testing strategy for the tailor-made carcinogenicity evaluation of test materials, considering the relationships among genotoxicity test results (Ames, in vitro mammalian genotoxicity and in vivo micronucleus), carcinogenicity test results and chemical properties (molecular weight, logKow and 179 organic functional groups). Read More

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December 2018

Comprehensive characterization of in vivo metabolic profile of Polygalae radix based on ultra-high-performance liquid chromatography-tandem mass spectrometry.

J Pharm Biomed Anal 2018 Dec 5;165:173-181. Epub 2018 Dec 5.

National Center of Mass Spectrometry in Changchun and Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry and Chemical Biology Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; University of Science and Technology of China, Hefei, 230026, China. Electronic address:

In this study, a novel analysis strategy for progressively targeted screening and characterization of drug ingredients from in vitro to in vivo was proposed based on ultra-high performance liquid chromatography-tandem mass spectrometry for comprehensive characterization of in vivo metabolic profile of Polygalae radix (PR). First, an in vitro chemical profile of PR was described with the assistance of UNIFI™ software. The characteristic neutral small molecule losses were summarized to distinguish different chemical structures in the PR extract. Read More

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December 2018
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The high prevalence of pre-existing mental health complaints in clients attending Saint Mary's Sexual Assault Referral Centre: Implications for initial management and engagement with the Independent Sexual Violence Advisor service at the centre.

J Forensic Leg Med 2018 Dec 5;61:102-107. Epub 2018 Dec 5.

Saint Mary's Sexual Assault Referral Centre, York Place, Oxford Road, Manchester, M13 9WL, UK. Electronic address:

Background: The Saint Mary's Sexual Assault Referral Centre has a unique service delivery model whereby it provides an integrated physical and psychological support services to clients, women men and children, living in Greater Manchester. The service is available to those who have reported rape or sexual assault, whether this is recent or historic. Clients living in surrounding areas of Cheshire are provided with forensic and medical services at Saint Mary's Centre, with follow-up care provided locally, as appropriate. Read More

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December 2018

Rapid determination of 1,3-propanediol in fermentation process based on a novel surface-enhanced Raman scattering biosensor.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Nov 28;211:227-233. Epub 2018 Nov 28.

Beijing Bioprocess Key Laboratory, Beijing University of Chemical Technology, Beijing 100029, PR China; College of Science, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address:

The production of 1,3-propanediol (1,3-PDO) is an important fermentation process. However, 1,3-PDO could not be distinguished separately and efficiently in fermentations previously because it has a highly similar molecular structure to the feedstock glycerol (GLY) and by-product lactic acid (Lac), which leads to the difficulty of quantification. In this paper, a low-cost and environmentally friendly biosensor based on surface-enhanced Raman scattering (SERS) technique was developed. Read More

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November 2018

When is a "cryptic" species not a cryptic species: A consideration from the Holarctic micro-landsnail genus Euconulus (Gastropoda: Stylommatophora).

Mol Phylogenet Evol 2018 Dec 11. Epub 2018 Dec 11.

Department of Botany and Zoology, Masaryk University, Kotlářská 2, CZ-61137, Brno, Czechia. Electronic address:

Naive use of molecular data may lead to ambiguous conclusions, especially within the context of "cryptic" species. Here, we integrated molecular and morphometric data to evaluate phylogenetic relationships in the widespread terrestrial micro-snail genus, Euconulus. We analyzed mitochondrial (16S + COII) and nuclear (ITS1 + ITS2) sequence across 94 populations from Europe, Asia and North America within the nominate species E. Read More

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December 2018