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    1 OF 133

    Baicalein protects rat insulinoma INS-1 cells from palmitate-induced lipotoxicity by inducing HO-1.
    PLoS One 2017 26;12(4):e0176432. Epub 2017 Apr 26.
    Department of Pharmacology, Gachon University College of Medicine, Incheon, Republic of Korea.
    Objective: β-Cell dysfunction plays a central role in the pathogenesis of type 2 diabetes (T2D), and the identification of novel approaches to improve β-cell function is essential to treat this disease. Baicalein, a flavonoid originally isolated from the root of Scutellaria Baicalensis, has been shown to have beneficial effects on β-cell function. Here, the authors investigated the molecular mechanism responsible for the protective effects of baicalein against palmitate (PA)-induced impaired β-cell function, and placed focus on the role of heme oxygenase (HO)-1. Read More

    Deciphering tacrolimus-induced toxicity in pancreatic β-cells.
    Am J Transplant 2017 Apr 22. Epub 2017 Apr 22.
    Centre for Biomedical Research of the Canary Islands (CIBICAN), University of La Laguna, Tenerife, Spain.
    β-cell transcription factors like: FoxO1, MafA, PDX-1, NeuroD, are dysfunctional in type 2 diabetes (T2DM). PTDM resembles T2DM and reflects interaction between pre-transplant insulin resistance and immunosuppressants, mainly calcineurin inhibitors. We evaluated the effect of tacrolimus, cyclosporine-A and metabolic stressors (glucose+palmitate) on insulinoma β-cells (INS-1) in vitro and in pancreata of obese and lean Zucker rats. Read More

    Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R.
    Sci Rep 2017 Apr 20;7(1):979. Epub 2017 Apr 20.
    USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
    Orexigenic hormone ghrelin and anorexic hormone obestatin are encoded by the same preproghrelin gene. While it is known that ghrelin inhibits glucose-stimulated insulin secretion (GSIS), the effect of obestatin on GSIS is unclear. Ghrelin's effect is mediated by its receptor Growth Hormone Secretagogue Receptor (GHS-R), but the physiologically relevant receptor of obestatin remains debatable. Read More

    Hypoglycemia identified by a continuous glucose monitoring system in a second-trimester pregnant woman with insulinoma: a case report.
    J Med Case Rep 2017 Apr 21;11(1):117. Epub 2017 Apr 21.
    Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center Ljubljana, Zaloška 7, Ljubljana, 1525, Slovenia.
    Background: Insulinoma associated with pregnancy is a very rare condition and can be difficult to diagnose. Here, we present an interesting case of insulinoma occurring during pregnancy with special attention paid to the use of a continuous glucose monitoring system to detect hypoglycemia.

    Case Presentation: A 36-year-old white woman in the second trimester of pregnancy presented with recurrent episodes of hypoglycemia associated with neuroglycopenic symptoms. Read More

    Prospective comparison of biphasic contrast-enhanced CT, volume perfusion CT, and 3 Tesla MRI with diffusion-weighted imaging for insulinoma detection.
    J Magn Reson Imaging 2017 Apr 17. Epub 2017 Apr 17.
    Department of Radiology, Peking Union Medical College Hospital, Beijing, China.
    Purpose: To evaluate the diagnostic performance of biphasic contrast-enhanced CT (CECT), volume perfusion CT (VPCT) and 3 Tesla MRI with diffusion-weighted imaging (DWI), in patients with clinically suspected insulinomas.

    Materials And Methods: This prospective study was approved by the institutional review board. Sixty-four patients with clinically suspected insulinomas underwent biphasic CECT, VPCT, and 3T MR with DWI. Read More

    Glycogen phosphorylase inhibition improves β-cell function.
    Br J Pharmacol 2017 Apr 13. Epub 2017 Apr 13.
    Departments of Medical Chemistry, University of Debrecen, Debrecen, H-4032, Hungary.
    Background And Purpose: Glycogen phosphorylase (GP) is the key enzyme for glycogen degradation. GP inhibitors (GPi-s) are glucose lowering agents trapping glucose in the liver as glycogen. Glycogen metabolism has implications in β-cell function; glycogen degradation can maintain cellular glucose levels, which feeds into catabolism to maintain insulin secretion, and elevated glycogen degradation levels contribute to glucotoxicity. Read More

    Toward molecular imaging of the free fatty acid receptor 1.
    Acta Diabetol 2017 Apr 13. Epub 2017 Apr 13.
    Division of Molecular Imaging, Department of Medicinal Chemistry, Uppsala University, SE-751 83, Uppsala, Sweden.
    Aims: Molecular imaging of the free fatty acid receptor 1 (FFAR1) would be a valuable tool for drug development by enabling in vivo target engagement studies in human. It has also been suggested as a putative target for beta cell imaging, but the inherent lipophilicity of most FFAR1 binders produces high off-target binding, which has hampered progress in this area. The aim of this study was to generate a suitable lead compound for further PET labeling. Read More

    Molecular imaging in the investigation of hypoglycaemic syndromes and their management.
    Endocr Relat Cancer 2017 Apr 11. Epub 2017 Apr 11.
    R Hicks, Centre for Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Australia.
    There has been recent progress in molecular imaging using a variety of cellular targets for the investigation of adult non-diabetic hypoglycaemic syndromes and its integration into patient management. These targets include peptide receptors - somatostatin receptors (SSTR) and glucagon-like peptide-1 receptor (GLP-1R) - the Amine Precursor Uptake and Decarboxylation system utilising the diphydroxyphenylaline (DOPA) analogue 6-[18F]-L-fluoro-L-3, 4-dihydroxyphenylalanine (18F-FDOPA), and glycolytic metabolism with 2-[18F]Fluoro-2-Deoxy-D-Glucose (FDG). Accurate pre-operative localisation and staging is critical to enable directed surgical excision or enucleation with minimal morbidity and preservation of residual pancreatic function. Read More

    Thyroid and Islet Autoantibodies Predict Autoimmune Thyroid Disease at Type 1 Diabetes Diagnosis.
    J Clin Endocrinol Metab 2017 Apr;102(4):1277-1285
    Department of Clinical Sciences, Lund University, Skåne University Hospital, SE-205 02 Malmö, Sweden.
    Context: Screening of autoimmune thyroid disease in children with type 1 diabetes is important but varies between clinics.

    Objective: To determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA-DQ at diagnosis of type 1 diabetes for autoimmune thyroid disease during follow-up.

    Setting: Forty-three Swedish pediatric endocrinology units. Read More

    [Clinical approach of a suspicion of hypoglycaemic malaise in a nondiabetic adult].
    Rev Med Liege 2016 Sep;71(9):407-413
    Université de Liège, Belgique.
    Malaises are often attributed to hypoglycaemia in nondiabetic people who don't have any other serious medical problem. However, such a diagnosis is often overused, because not really demonstrated in most instances. The diagnosis of hypoglycaemia should be structured, based upon the Whipple triad. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Pathogenesis and management of hypoglycemia.
    Eur J Endocrinol 2017 Apr 5. Epub 2017 Apr 5.
    A Vella, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic Minnesota, Rochester, United States
    Glucose is the main substrate utilized by the brain and as such multiple regulatory mechanisms exist to maintain glucose concentrations. When these mechanisms fail or are defective hypoglycemia ensues. Due to these robust mechanisms hypoglycemia is uncommon and usually occurs in the setting of the treatment of diabetes using glucose- lowering agents such as sulfonylureas or insulin. Read More

    A novel multi-epitope vaccine based on Dipeptidyl Peptidase 4 prevents streptozotocin-induced diabetes by producing anti-DPP4 antibody and immunomodulatory effect in C57BL/6J mice.
    Biomed Pharmacother 2017 Mar 31;89:1467-1475. Epub 2017 Mar 31.
    School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address:
    Type 1 diabetes is a chronic organ-specific autoimmune disease in which selective destruction of insulin-producing β-cells leads to impaired glucose metabolism and its attendant complications. A series of Dipeptidyl peptidase 4 (DPP4) inhibitors have been developed and granted approval in the treatment of type 2 diabetes mellitus by inhibiting the enzymatic degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). An increasing number of studies have shown the potential benefits of DPP4 inhibitors for type 1 diabetes. Read More

    Pancreas and liver uptake of new radiolabeled incretins (GLP-1 and Exendin-4) in models of diet-induced and diet-restricted obesity.
    Nucl Med Biol 2017 Mar 18;49:57-64. Epub 2017 Mar 18.
    Department of Gastroenterology, Hospital das Clínicas, Av. Enéas C. Aguiar, 255, 9th Floor, Rm 9077, São Paulo, 05403-900, Brazil.
    Introduction: Radiolabeled GLP-1 and its analog Exendin-4, have been employed in diabetes and insulinoma. No protocol in conventional Diet-Induced Obesity (DIO), and Diet-Restricted Obesity (DRO), has been identified. Aiming to assess pancreatic beta cell uptake in DIO and DRO, a protocol was designed. Read More

    Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells.
    Eur J Pharm Sci 2017 Mar 29. Epub 2017 Mar 29.
    Faculty of Health Sciences, University of Macau, Taipa, Macau, China.
    Our previous work revealed that in the pancreatic β cell line, geniposide modulated ATP production and glucose-stimulated insulin secretion (GSIS) induced by the acute stimulation of high glucose concentration. However, the effects of geniposide on functional impairment and the mass of β-cells exposed to elevated levels of glucose remains unknown. In the present study, impaired GSIS and restrained proliferation were observed in the prolonged culture of insulinoma INS-1 cells with 33mM of glucose (high glucose). Read More

    Evolving management of insulinoma: Experience at a tertiary care centre.
    Indian J Med Res 2016 Nov;144(5):771
    Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
    Background & Objectives: Since our previous study in 2006, several new modalities for localization of cause of endogenous hyperinsulinemic hypoglycaemia such as multiphasic computed tomography (CT), multiphasic magnetic resonance imaging (MRI), endoscopic ultrasound (EUS), intraoperative ultrasound, and intra-arterial calcium infusion with arterial stimulation venous sampling (ASVS) have become available. Therefore, to evaluate the relative usefulness of various imaging modalities to guide future management in terms of diagnosis and patient care, we analyzed presentation and management of patients of endogenous hyperinsulinemic hypoglycaemia.

    Methods: In this retrospective study, medical records of patients admitted with endogenous hyperinsulinemic hypoglycaemia were retrieved. Read More

    Type 1 diabetes mellitus.
    Nat Rev Dis Primers 2017 Mar 30;3:17016. Epub 2017 Mar 30.
    Department of Clinical Sciences, Lund University, Skåne University Hospital, Jan Waldenströms gata 35, 20502 Malmö, Sweden.
    Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease characterized by insulin deficiency due to pancreatic β-cell loss and leads to hyperglycaemia. Although the age of symptomatic onset is usually during childhood or adolescence, symptoms can sometimes develop much later. Although the aetiology of T1DM is not completely understood, the pathogenesis of the disease is thought to involve T cell-mediated destruction of β-cells. Read More

    Streptozotocin produces oxidative stress, inflammation and decreases BDNF concentrations to induce apoptosis of RIN5F cells and type 2 diabetes mellitus in Wistar rats.
    Biochem Biophys Res Commun 2017 Apr 15;486(2):406-413. Epub 2017 Mar 15.
    BioScience Research Centre, Department of Medicine, Gayatri Vidya Parishad Hospital, GVP College of Engineering Campus, Visakhapatnam 530048, India; UND Life Sciences, 2221, NW 5th St, Battle Ground, WA 98604, USA. Electronic address:
    Background: Neurodegenerative disorders, such as deficits in learning, memory and cognition and Alzheimer's disease are associated with diabetes mellitus. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor and is known to possess anti-obesity, anti-diabetic actions and is believed to have a role in memory and Alzheimer's disease.

    Objective: To investigate whether STZ can reduce BDNF production by rat insulinoma (RIN5F) cells in vitro and decrease BDNF levels in the pancreas, liver and brain in vivo. Read More

    Small pancreatic insulinoma: Successful endoscopic ultrasound-guided radiofrequency ablation in a single session, using a 22G fine needle.
    Dig Endosc 2017 Mar 14. Epub 2017 Mar 14.
    Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, Catalonia, Spain.
    A 63-year-old woman, morbidly obese, with clinical symptoms of periodic hypoglycemic episodes, was diagnosed with an insulinoma in pancreatic body that had not been detected by previous computed tomography and magnetic resonance. This neuroendocrine tumour was identified by EUS as a hypoechoic lesion with some iso-hyperechoic tracts, measuring 9 x 10 mm, and 4-5 mm from splenic vessels (Figure 1a). This article is protected by copyright. Read More

    The endoplasmic reticulum stress/autophagy pathway is involved in cholesterol-induced pancreatic β-cell injury.
    Sci Rep 2017 Mar 15;7:44746. Epub 2017 Mar 15.
    Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
    Lipotoxicity has been implicated in pancreatic β-cell dysfunction in type 2 diabetes, but the exact mechanisms remain unknown. The current study explored the role of the endoplasmic reticulum (ER) stress pathway in cholesterol-induced lipotoxicity. Two different insulinoma cell lines were treated with cholesterol with or without inhibitors. Read More

    Characteristics of glucose metabolism indexes and continuous glucose monitoring system (CGMS) in patients with insulinoma.
    Diabetol Metab Syndr 2017 14;9:17. Epub 2017 Mar 14.
    Department of Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing, 100853 People's Republic of China.
    Aims: Analyze the clinical applicability of glucose metabolism indexes and continuous glucose monitoring data on the qualitative diagnosis of insulinoma.

    Methods: Involve 22 patients with insulinoma (insulinoma group), 11 patients with hypoglycemia (hypoglycemia group) and 31 people with normal glucose tolerance (control group). HbA1c, fasting blood glucose (FBG), insulin (FINS) and C-peptide (FCP) was tested. Read More

    Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo.
    Nutrition 2017 Mar 15;35:61-80. Epub 2016 Oct 15.
    BioScience Research Centre, Department of Medicine, Gayatri Vidya Parishad Hospital, GVP College of Engineering Campus, Visakhapatnam, India; UND Life Sciences, Federal Way, Washington. Electronic address:
    Objective: The aim of this study was to observe whether polyunsaturated fatty acids (PUFAs) can protect rat insulinoma (RIN5 F) cells against streptozotocin (STZ)-induced apoptosis in vitro and type 1 diabetes mellitus (T1DM) and type 2 DM (T2DM) in vivo and if so, what would be the mechanism of this action.

    Methods: RIN5 F cells were used for the in vitro study, whereas the in vivo study was performed in Wistar rats. STZ was used to induce apoptosis of RIN5 F cells in vitro and T1- and T2DM in vivo. Read More

    Diagnostic Performance of 48-Hour Fasting Test and Insulin Surrogates in Patients With Suspected Insulinoma.
    Pancreas 2017 Apr;46(4):476-481
    From the *Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University; †Department of Gastroenterology, National Hospital Organization, Kyushu Medical Center; ‡Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; and §Digestive Diseases Branch, National Institutes of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD.
    Objectives: This study aimed to evaluate the usefulness of the 48-hour fasting test and insulin surrogates followed by a glucagon stimulatory test (GST) for the diagnosis of insulinoma.

    Methods: Thirty-five patients with suspected insulinoma who underwent 48-hour fasting test and GST were retrospectively included in our study: 15 patients with surgically proven insulinomas and 20 patients in whom insulinoma was clinically ruled out. We determined the duration of the fasting test, plasma glucose levels, serum levels of immunoreactive insulin and C-peptide, and insulin surrogates (serum levels of β-hydroxybutyrate, free fatty acid, and response of plasma glucose to intravenous glucagon [ΔPG]) at the end of the fast. Read More

    A variant in a cis-regulatory element enhances claudin-14 expression and is associated with pediatric-onset hypercalciuria and kidney stones.
    Hum Mutat 2017 Feb 22. Epub 2017 Feb 22.
    Department of Pediatrics, The University of Alberta, Edmonton, Alberta, T6G 2R7, Canada.
    The greatest risk factor for kidney stones is hypercalciuria, the etiology of which is largely unknown. A recent genome-wide association study (GWAS) linked hypercalciuria and kidney stones to a claudin-14 (CLDN14) risk haplotype. However, the underlying molecular mechanism was not delineated. Read More

    Laparoscopic Resection of Pancreatic Tumors in Children: Results of a Multicentric Survey.
    J Laparoendosc Adv Surg Tech A 2017 Feb 22. Epub 2017 Feb 22.
    6 Department of Pediatric Surgery, Wilhelmina Children's Hospital, University Medical Centre , Utrecht, The Netherlands .
    Aim: This study aimed to report the results of a multicentric survey about laparoscopic treatment of pancreatic tumors in children.

    Materials And Methods: The data of patients operated using minimally invasive surgery (MIS) for a pancreatic tumor in 5 International centers of Pediatric Surgery in the last 5 years were retrospectively reviewed. We recorded data relating to the clinical presentation, diagnostic evaluation, surgical technique, and outcome. Read More

    Decreased levels of Fibroblast Growth Factor 21 are correlated with improved hypoglycemia in patients with insulinoma.
    Sci Rep 2017 Feb 22;7:43123. Epub 2017 Feb 22.
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600Yishan road, Shanghai, 200233 China.
    Fibroblast growth factor-21 (FGF-21) improves insulin sensitivity and lipid metabolism in obese or diabetic animal models and has been proposed as a potential therapeutic agent for treating T2DM, obesity, and their related complications. However, little is known about the changes of FGF21 levels in response to endogenous hyperinsulinemic hypoglycemia. To explore its relationship with parameters of glucose metabolism in patients with insulinoma, eleven subjects with pathological insulinoma and twenty-two healthy subjects were recruited for this study. Read More

    Glycemic control in patients with insulinoma.
    Hormones (Athens) 2016 Oct;15(4):489-499
    Department of Disaster Medicine, Warsaw Medical University, Warsaw, Poland.
    Insulinoma is the most common neuroendocrine tumor of the pancreas. Surgical management of insulinomas is considered to be the only curative method. However, effective glycemic control preoperatively and in unresectable insulinomas remains a significant issue. Read More

    B-mode and contrast-enhancement characteristics of small nonincidental neuroendocrine pancreatic tumors.
    Endosc Ultrasound 2017 Jan-Feb;6(1):49-54
    Medical Department, Caritas-Krankenhaus, Uhlandstr. 7 D-97980 Bad Mergentheim, Germany; Sino-German Research Center of Ultrasound in Medicine, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    Background And Objectives: Imaging of the pancreas for detection of neuroendocrine tumors is indicated as surveillance in multiple endocrine neoplasia type 1 (MEN1) or if typical clinical symptoms combined with hormone production raise the suspicion of a neuroendocrine tumor. Endoscopic ultrasound (EUS) is considered the best imaging modality to detect small pancreatic tumors. However, little is known about how small pancreatic neuroendocrine tumors (pNETs) present on EUS. Read More

    Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification.
    Biochim Biophys Acta 2017 Apr 12;1860(4):427-437. Epub 2017 Feb 12.
    Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR5286, Université Lyon 1, Lyon, France. Electronic address:
    Although Men1 is a well-known tumour suppressor gene, little is known about the functions of Menin, the protein it encodes for. Since few years, numerous publications support a major role of Menin in the control of epigenetics gene regulation. While Menin interaction with MLL complex favours transcriptional activation of target genes through H3K4me3 marks, Menin also represses gene expression via mechanisms involving the Polycomb repressing complex (PRC). Read More

    Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival.
    PLoS One 2017 17;12(2):e0172567. Epub 2017 Feb 17.
    Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.
    Increased β-cell death coupled with the inability to replicate existing β-cells drives the decline in β-cell mass observed in the progression of both major forms of diabetes. Understanding endogenous mechanisms of islet cell survival could have considerable value for the development of novel strategies to limit β-cell loss and thereby promote β-cell recovery. Insulinoma cells have provided useful insight into β-cell death pathways but observations made in cell lines sometimes fail to translate to primary islets. Read More

    Paroxysmal Hypertension Induced by an Insulinoma.
    Intern Med 2017 15;56(4):413-417. Epub 2017 Feb 15.
    Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
    Insulinoma is a rare, usually benign, pancreatic neuroendocrine tumor. The clinical features of an insulinoma are fasting hypoglycemia with neuroglycopenic symptoms including confusion and unusual behavior, while hypertension is usually not associated with the disease. We herein report a patient with insulinoma who manifested paroxysmal hypertension and neuroglycopenic symptoms. Read More

    Apigenin attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense.
    In Vitro Cell Dev Biol Anim 2017 Feb 8. Epub 2017 Feb 8.
    Department of Biochemistry, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People's Republic of China.
    Pancreatic beta cells are very sensitive to oxidative stress, which is one of the major causes of cell damages in diabetes. Growing interest has focused on the development of effective therapeutics to protect pancreatic cells from oxidative stress and searching for potentially protective antioxidants for treating diabetes. Apigenin, a plant-derived flavonoid, was investigated to determine whether it could protect rat insulinoma cell lines (RINm5F pancreatic beta cells) against streptozotocin (STZ)-induced oxidative damages and the mechanisms implicated. Read More

    Hepcidin links gluco-toxicity to pancreatic beta cell dysfunction by inhibiting Pdx-1 expression.
    Endocr Connect 2017 Apr 8;6(3):121-128. Epub 2017 Feb 8.
    Department of Central LaboratoryJiangsu Province Official Hospital, Nanjing, Jiangsu, China
    Objective: Gluco-toxicity is a term used to convey the detrimental effect of hyperglycemia on β-cell function through impaired insulin synthesis. Although it is known that the expression and activity of several key insulin transcription regulators is inhibited, other molecular mechanisms that mediate gluco-toxicity are poorly defined. Our objective was to explore the role of hepcidin in β-cell gluco-toxicity. Read More

    Evaluation of the influence of the conjugation site of the chelator agent HYNIC to GLP1 antagonist radiotracer for insulinoma diagnosis.
    Curr Radiopharm 2017 Jan 26. Epub 2017 Jan 26.
    Institute of Energy and Nuclear Research Radiopharmacy Center Av. Prof. Lineu Prestes, 2242 São Paulo,. Brazil.
    Radiotracer diagnosis of insulinoma, can be done using somatostatin or glucagon-like peptide 1 (GLP-1). Performance of GLP-1 antagonists tends to be better than of agonists. We investigated the uptake of the antagonist exendin (9-39), radiolabeled with technetium-99m. Read More

    7, 8-Dihydroxycoumarin (daphnetin) protects INS-1 pancreatic β-cells against streptozotocin-induced apoptosis.
    Phytomedicine 2017 Jan 1;24:119-126. Epub 2016 Dec 1.
    Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai, Guangdong 519085, China. Electronic address:
    Background And Objective: Daphnetin (7, 8-dihydroxycoumarin), a natural coumarin compound, is known to exhibit antioxidant and anti-inflammatrory effects. However, the underlying mechanisms of its anti-apoptotic and antidiabetic effects yet not been examined. Therefore, the present work studied the anti-apoptotic and anti-diabetic effects of daphnetin by in vitro experiments. Read More

    Endoscopic Radiofrequency Ablation of the Pancreas.
    Dig Dis Sci 2017 Apr 3;62(4):843-850. Epub 2017 Feb 3.
    Department of Internal Medicine, Waterbury Hospital, Waterbury, CT, USA.
    Radiofrequency ablation (RFA) is a well-established technique to ablate dysplastic and neoplastic tissue via local thermal coagulative necrosis. Despite the widespread use in management of several cancers, the application of RFA in pancreas has been limited due to the increased risks of complications from the increased sensitivity of pancreatic tissue to thermal injury and proximity to vascular and biliary structures. RFA has been successfully used during laparotomy for locally advanced pancreatic carcinoma but requires an invasive approach. Read More

    Resection of postoperative liver metastasis from pancreatic neuroendocrine tumors: report of one case.
    Transl Gastroenterol Hepatol 2016 1;1:47. Epub 2016 Jun 1.
    Department of Abdominal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Cancer Center of China, Beijing 100021, China.
    Pancreatic neuroendocrine tumor (pNET) is a rare type of pancreatic tumors. The incidence of pNET shows a gradually increasing trend in recent years. Except insulinoma, majority of pNET are metastatic when diagnosis. Read More

    68Ga-Exendin-4 PET/CT in Evaluation of Endoscopic Ultrasound-Guided Ethanol Ablation of an Insulinoma.
    Clin Nucl Med 2017 Apr;42(4):310-311
    From the Departments of *Nuclear Medicine, †Gastroenterology, and ‡Endocrinology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.
    A 32-year-old man with endogenous hyperinsulinemic hypoglycemia was clinically diagnosed with an insulinoma. Conventional imaging result was negative, and a previous exploratory laparotomy with distal pancreatectomy failed to detect the tumor. Ga-exendin-4 PET/CT showed a lesion with intense radioactivity in the head of the pancreas suggestive of an insulinoma, and endoscopic ultrasound-guided ethanol ablation was performed. Read More

    [Multiple Endocrine Neoplasia Type 1(MEN1)Presenting with Hypoglycemic Attacks - A Case Report].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2196-2198
    Dept. of Surgery, Kobe Ekisaikai Hospital.
    A woman in her 60s visited our hospital because of frequent hypoglycemia and episodes of unconsciousness over the last 6 years. A 4 cm tumor was detected on the pancreatic tail using abdominal computed tomography and ultrasonography. An insulinoma was strongly suspected from the results of the fasting test and glucagon load test, and a distal pancreatectomy with splenectomy was performed. Read More

    Coupling of Insulin Secretion and Display of a Granule-resident Zinc Transporter ZnT8 on the Surface of Pancreatic Beta Cells.
    J Biol Chem 2017 Mar 27;292(10):4034-4043. Epub 2017 Jan 27.
    From the Department of Physiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205
    The islet-specific zinc transporter ZnT8 mediates zinc enrichment in the insulin secretory granules of the pancreatic beta cell. This granular zinc transporter is also a major self-antigen found in type 1 diabetes patients. It is not clear whether ZnT8 can be displayed on the cell surface and how insulin secretion may regulate the level of ZnT8 exposure to extracellular immune surveillance. Read More

    Sporadic insulinomas on volume perfusion CT: dynamic enhancement patterns and timing of optimal tumour-parenchyma contrast.
    Eur Radiol 2017 Jan 20. Epub 2017 Jan 20.
    Department of Radiology, Peking Union Medical College Hospital, Shuaifuyuan No.1, Dongcheng District, Beijing, China.
    Objectives: To assess enhancement patterns of sporadic insulinomas on volume perfusion CT (VPCT), and to identify timing of optimal tumour-parenchyma contrast.

    Methods: Consecutive patients who underwent VPCT for clinically suspected insulinomas were retrospectively identified. Patients with insulinomas confirmed by surgery were included, and patients with familial syndromes were excluded. Read More

    Sirtuin 1 independent effects of resveratrol in INS-1E β-cells.
    Chem Biol Interact 2017 Feb 17;264:52-60. Epub 2017 Jan 17.
    Department of Science and Environment, Roskilde University, Roskilde, Denmark. Electronic address:
    Resveratrol (Resv), a natural polyphenol, is suggested to have various health benefits including improved insulin sensitivity. Resv activates Sirtuin (Sirt1) in several species and tissues. Sirt1 is a protein deacetylase with an important role in ageing, metabolism and β-cell function. Read More

    Radioiodinated Exendin-4 Is Superior to the Radiometal-Labelled Glucagon-Like Peptide-1 Receptor Probes Overcoming Their High Kidney Uptake.
    PLoS One 2017 19;12(1):e0170435. Epub 2017 Jan 19.
    Department of Nuclear Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
    GLP-1 receptors are ideal targets for preoperative imaging of benign insulinoma and for quantifying the beta cell mass. The existing clinical tracers targeting GLP-1R are all agonists with low specific activity and very high kidney uptake. In order to solve those issues we evaluated GLP-1R agonist Ex-4 and antagonist Ex(9-39) radioiodinated at Tyr40 side by side with [Nle14,Lys40(Ahx-DOTA-68Ga)NH2]Ex-4 (68Ga-Ex-4) used in the clinic. Read More

    Development of (111)In-labeled exendin(9-39) derivatives for single-photon emission computed tomography imaging of insulinoma.
    Bioorg Med Chem 2017 Feb 3;25(4):1406-1412. Epub 2017 Jan 3.
    Department of Patho-Functional Bioanalysis, Kyoto University Graduate School of Pharmaceutical Sciences, 46-29, Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:
    Insulinoma is a tumor derived from pancreatic β-cells, and the resulting hyperinsulinemia leads to characteristic hypoglycemia. Recent studies have reported the frequent overexpression of glucagon-like peptide-1 receptor (GLP-1R) in human insulinomas, suggesting that the binding of a radiolabeled compound to GLP-1R is useful for the imaging of such tumors. Exendin(9-39), a fragment peptide of exendin-3 and -4, binds GLP-1R with high affinity and acts as an antagonist. Read More

    Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
    Sci Rep 2017 Jan 10;7:40495. Epub 2017 Jan 10.
    David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, U.S.A.
    The angiogenic switch, the time at which a tumor becomes vascularized, is a critical step in tumor progression. Indeed, without blood supply, tumors will fail to grow beyond 1 mm(3) and are unlikely to disseminate. The extracellular matrix (ECM), a major component of the tumor microenvironment, is known to undergo significant changes during angiogenesis and tumor progression. Read More

    REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.
    Proc Natl Acad Sci U S A 2017 Jan 3;114(3):E406-E415. Epub 2017 Jan 3.
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239;
    The transcriptional events that lead to the cessation of neural proliferation, and therefore enable the production of proper numbers of differentiated neurons and glia, are still largely uncharacterized. Here, we report that the transcription factor Insulinoma-associated 1 (INSM1) forms complexes with RE1 Silencing Transcription factor (REST) corepressors RCOR1 and RCOR2 in progenitors in embryonic mouse brain. Mice lacking both RCOR1 and RCOR2 in developing brain die perinatally and generate an abnormally high number of neural progenitors at the expense of differentiated neurons and oligodendrocyte precursor cells. Read More

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