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    1 OF 136

    Concurrent endocrine neoplasias in dogs and cats: a retrospective study (2004-2014).
    Vet Rec 2018 Jan 19. Epub 2018 Jan 19.
    Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
    Multiple endocrine neoplasia (MEN) is a well-known syndrome in human medicine, whereas only a few cases of concurrent endocrine neoplasias have been reported in dogs and cats. The aim of this study was to evaluate the prevalence of concurrent endocrine neoplasias in dogs and cats at our clinic, identify possible breed and sex predispositions and investigate similarities with MEN syndromes in humans. Postmortem reports of 951 dogs and 1155 cats that died or were euthanased at the Clinic for Small Animal Internal Medicine, University of Zurich, between 2004 and 2014 were reviewed, and animals with at least two concurrent endocrine neoplasias and/or hyperplasias were included. Read More

    Early Infant Diet and Islet Autoimmunity in the TEDDY Study.
    Diabetes Care 2018 Jan 17. Epub 2018 Jan 17.
    Department of Epidemiology, University of Colorado Denver, Colorado School of Public Health, Aurora, CO.
    Objective: To examine duration of breastfeeding and timing of complementary foods and risk of islet autoimmunity (IA).

    Research Design And Methods: The TEDDY study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes (T1D) in the U.S. Read More

    MAFA missense mutation causes familial insulinomatosis and diabetes mellitus.
    Proc Natl Acad Sci U S A 2018 Jan 16. Epub 2018 Jan 16.
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, EX2 5DW Exeter, United Kingdom.
    The β-cell-enriched MAFA transcription factor plays a central role in regulating glucose-stimulated insulin secretion while also demonstrating oncogenic transformation potential in vitro. No disease-causing MAFA variants have been previously described. We investigated a large pedigree with autosomal dominant inheritance of diabetes mellitus or insulinomatosis, an adult-onset condition of recurrent hyperinsulinemic hypoglycemia caused by multiple insulin-secreting neuroendocrine tumors of the pancreas. Read More

    An observational analysis of insulinoma from 1 single institution.
    QJM 2018 Jan 8. Epub 2018 Jan 8.
    Division of Endocrinology, Tongji Hospital, Huazhong University of Science & Technology, Wuhan, PR China, 430030.
    Background: Insulinoma is the commonest functioning pancreatic neuroendocrine tumor causing hyperinsulinemic hypoglycemia. This study is aimed to evaluate the clinical features, preoperative laboratory and imaging diagnosis, and pathologic findings of insulinoma.

    Methods: Data of the patients from 2001 to 2016 diagnosed as insulinoma in Tongji Hospital, China were retrospectively extracted and analyzed. Read More

    Rare Cause of Recurrent Hypoglycemia: Insulin Autoimmune Syndrome.
    Case Rep Endocrinol 2017 26;2017:6423852. Epub 2017 Nov 26.
    Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    We report a case of insulin autoimmune syndrome associated with several autoantibodies, presenting with recurrent hypoglycemia, predominantly in the postprandial period, which improved by dietary management and spontaneously resolved within two months. Differentiation from other causes of hyperinsulinemic hypoglycemia, such as insulinoma, is important to avoid unnecessary invasive procedures or surgical interventions. The 75-gram oral glucose tolerance test (OGTT) and mixed meal test showed a typical pattern, which may be useful indirect evidence of insulin autoimmune syndrome. Read More

    A novel synthetic human insulin super promoter for targeting PDX-1-expressing pancreatic cancer.
    Cancer Lett 2018 Jan 5. Epub 2018 Jan 5.
    Our previous studies have shown that a rat insulin promoter II fragment (RIP) was used to effectively target pancreatic adenocarcinoma (PDAC) and insulinoma that over-express pancreatic and duodenal homeobox-1 (PDX-1). To enhance the activity and specificity of the human insulin promoter, we engineered a synthetic human insulin super-promoter (SHIP). Reporter assay demonstrated that SHIP1 was the most powerful promoter among all of the SHIPs and had far greater activity than the endogenous human insulin promoters and RIP in PDAC expressing PDX-1. Read More

    β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice.
    PLoS One 2018 5;13(1):e0190863. Epub 2018 Jan 5.
    Department of Health and Environmental Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    Adiponectin, a metabolically-active cytokine secreted from adipose tissue, is reported to have anti-apoptotic effects on β-cells as well as anti-hyperglycemic effects through adiponectin receptor signaling. However, the anti-apoptotic effects of adiponectin on β-cells have not been confirmed in established diabetic models, and the anti-hyperglycemic effects and their associated signal cascades remain controversial. To investigate the effects of adiponectin on β-cell protection and its down-stream signaling events, we have generated β-cell-specific rat insulin promoter (RIP)-AdipoR1 transgenic mice (AdipoR1 mice), in which the adiponectin receptor, AdipoR1, is overexpressed in β-cells in a manner synchronous with insulin demand. Read More

    Robotic enucleation of benign pancreatic tumors.
    J Vis Surg 2017 28;3:151. Epub 2017 Oct 28.
    The Pancreas and Liver Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
    Robot-assisted enucleation provides the dual benefits of a minimally-invasive technique and pancreatic parenchymal conservation to selected patients with functional pancreatic neuroendocrine tumors (F-pNETs) and serous cystadenomas. Insulinomas, the most common F-pNETs, are ideal candidates for enucleation when <2 cm given the 80% probability of being benign. Current evidence suggests enucleation for the following: benign, isolated lesions with a distance between tumor and main pancreatic duct ≥3 mm (no focal stricture or dilation), insulinomas, gastrinomas <2 cm, and nonfunctional pancreatic neuroendocrine tumors (NF-pNETs) <1-2 cm and low Ki67 mitotic index. Read More

    Amelioration of streptozotocin‑induced pancreatic β cell damage by morin: Involvement of the AMPK‑FOXO3‑catalase signaling pathway.
    Int J Mol Med 2018 Mar 29;41(3):1409-1418. Epub 2017 Dec 29.
    Department of Biochemistry, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
    Pancreatic β cells are sensitive to oxidative stress, which is one of the predominant causes of cell damage and the emergence of diabetes. The identification of effective therapeutic strategies to protect pancreatic cells from oxidative stress has increased interest in the screening of antioxidants from natural products. The present study aimed to investigate the protective effects of morin against streptozotocin (STZ)‑induced cell damage in a rat insulinoma cell line (RINm5F pancreatic β cells) and to identify the underlying mechanisms. Read More

    A Targeted RNAi Screen Identifies Endocytic Trafficking Factors that Control GLP-1 Receptor Signaling in Pancreatic Beta Cells.
    Diabetes 2017 Dec 28. Epub 2017 Dec 28.
    Section of Cell Biology and Functional Genomics and Pancreatic Islet Biology and Diabetes Consortium, Imperial College London, London, UK
    The GLP-1 receptor (GLP-1R) is a key target for type 2 diabetes (T2D) treatment. Since endocytic trafficking of agonist-bound receptors is one of the most important routes for regulation of receptor signaling, a better understanding of this process may facilitate the development of new T2D therapeutic strategies. Here, we have screened 29 proteins with known functions in G protein-coupled receptor trafficking for their role in GLP-1R potentiation of insulin secretion in pancreatic beta cells. Read More

    Hypoxia potentiates LPS-induced inflammatory response and increases cell death by promoting NLRP3 inflammasome activation in pancreatic β cells.
    Biochem Biophys Res Commun 2018 Jan 24;495(4):2512-2518. Epub 2017 Dec 24.
    Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China; Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China. Electronic address:
    Hypoxia and islet inflammation are involved in β-cell failure in type 2 diabetes (T2D). Elevated plasma LPS levels have been verified in patients with T2D, and hypoxia occurs in islets of diabetic mice. Activation of inflammasomes in ischemic or hypoxic conditions was identified in various tissues. Read More

    Clinical Value of 18F-FDOPA PET/CT With Contrast Enhancement and Without Carbidopa Premedication in Patients with Insulinoma.
    Anticancer Res 2018 01;38(1):353-358
    Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria
    Aim: We evaluated the clinical usefulness of 6-[18F]fluoro-3,4-dihydroxy-L-phenylalanine(18F-FDOPA)-positron-emission tomography (PET)/computed tomography (CT) in insulinoma detection with contrast enhancement, early acquisition time, and no carbidopa premedication.

    Patients And Methods: Twenty-six patients diagnosed with hyperinsulinemic hypoglycemia underwent an 18F-FDOPA PET/CT examination. Patients without carbidopa premedication and contrast-enhanced CT were included. Read More

    Pancreatectomies for pancreatic neoplasms in pediatric and adolescent age: A single institution experience.
    Pancreatology 2017 Dec 19. Epub 2017 Dec 19.
    Pancreatic Surgery Unit, Division of Surgery (KLINTEC) - Karolinska Institutet at Center for Digestive Diseases Karolinska University Hospital, Stockholm, Sweden. Electronic address:
    Background: There are very few data in the current literature regarding the short- and long-term outcome of surgery for pediatric pancreatic tumors (PPT). No data are available on the impact of pancreatic surgery on the children's growth.

    Methods: This is a retrospective cohort study on a consecutive series of pediatric/adolescent patients who underwent pediatric surgery at Karolinska University Hospital from January 2005 to July 2017. Read More

    Insulinoma-associated Protein 1 (INSM1) Differentiates Carcinoid Tumorlets of the Lung from Pulmonary Meningothelial-Like Nodules.
    Histopathology 2017 Dec 23. Epub 2017 Dec 23.
    Department of Pathology, Pathology and Laboratory Medicine Institute Cleveland Clinic.
    Insulinoma-associated protein 1 (INSM1) is a zinc-finger transcription factor isolated from pancreatic insulinoma tissue. This protein controls expression of a neuroendocrine phenotype and is responsible for transcription of synaptophysin and chromogranin. In recent years, it has emerged as a sensitive and specific immunohistochemical marker of neuroendocrine neoplasms, and is currently the only commercially available nuclear marker of neuroendocrine differentiation. Read More

    Insulinoma and Tuberous Sclerosis: A Possible Mechanistic Target of Rapamycin (mTOR) Pathway Abnormality?
    J Endocr Soc 2017 Sep 17;1(9):1120-1123. Epub 2017 Jul 17.
    Department of Endocrinology, Middlemore Hospital, Auckland 2104, New Zealand.
    A 23-year-old New Zealand Māori male with tuberous sclerosis (TSC) and associated neurocognitive abnormalities presented with altered behavior and increasing seizure frequency. Endogenous hyperinsulinemia from an underlying insulinoma was confirmed and this was managed surgically. This case represents only the sixth description of insulinoma in TSC to date. Read More

    Selective Arterial Calcium Stimulation With Hepatic Venous Sampling in Immune-Mediated Hypoglycemia.
    J Endocr Soc 2017 Jun 4;1(6):671-675. Epub 2017 May 4.
    Department of Radiology, Mayo Clinic School of Medicine, Rochester, Minnesota 55905.
    The purpose of the current study was to review the biochemical results of selective arterial calcium stimulation (SACST) with hepatic venous sampling in patients with immune-mediated hyperinsulinemic hypoglycemia. A retrospective review was undertaken of four patients with immune-mediated hyperinsulinemic hypoglycemia who underwent SACST with hepatic venous sampling from January 1996 to March 2014. Baseline systemic arterial and hepatic venous insulin concentrations (uIU/mL) were compared, and the absolute and relative-fold increase in hepatic venous insulin concentration after calcium stimulation was calculated. Read More

    [Functional diagnostics in endocrinology].
    Internist (Berl) 2018 Jan;59(1):38-47
    Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Campus Innenstadt, Ziemssenstraße 1, 80366, München, Deutschland.
    When investigating many endocrinological diseases, basal laboratory parameters are not sufficient to distinguish between physiological and pathological hormone secretion. Functional diagnostics plays a decisive role in this context. Stimulation and suppression tests are used depending on whether under- or over-function needs to be diagnosed. Read More

    SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.
    ACS Med Chem Lett 2017 Dec 21;8(12):1336-1340. Epub 2017 Nov 21.
    School of Pharmacy and Department of Chemistry, Sungkyunkwan University, Suwon 16419, South Korea.
    G-protein coupled receptor 40 (GPR40) has been considered to be an attractive drug target for the treatment of type 2 diabetes because of its role in free fatty acids-mediated enhancement of glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. A series of indole-5-propanoic acid compounds were synthesized, and their GPR40 agonistic activities were evaluated by nuclear factor of activated T-cells reporter assay and GSIS assay in the MIN-6 insulinoma cells. Three compounds, 8h (EC50 = 58. Read More

    Hormone secreting gastro-entero-pancreatic neuroendocrine neoplasias (GEP-NEN): When to consider, how to diagnose?
    Rev Endocr Metab Disord 2017 Dec 19. Epub 2017 Dec 19.
    Schwerpunkt Endokrinologie und Stoffwechselerkrankungen, I. Medizinischen Klinik und Poliklinik; ENETS center of excellence, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany.
    Neuroendocrine neoplasms of the digestive system (GEP-NEN) represent a heterogeneous group of malignancies with various clinical presentation and prognosis. GEP-NENs can potentially affect all organs of the gastrointestinal tract; characteristically they share the biological property to produce and secrete peptides and neuroamines. About 30% of GEP-NENs are hormonally active and can cause specific clinical syndromes. Read More

    Nano-Encapsulation of Bilirubin in Pluronic F127-Chitosan Improves Uptake in β Cells and Increases Islet Viability and Function after Hypoxic Stress.
    Cell Transplant 2017 Oct;26(10):1703-1715
    3 Department of Clinical Sciences, North Carolina State University, Raleigh, NC, USA.
    Pancreatic islet transplantation is the only curative, noninvasive treatment for type 1 diabetes mellitus; however, high rates of cell death in the immediate postimplantation period have limited the success of this procedure. Bilirubin, an endogenous antioxidant, can improve the survival of murine pancreatic allografts during hypoxic stress but has poor solubility in aqueous solutions. We hypothesized that nano-encapsulation of bilirubin in pluronic 127-chitosan nanoparticle bilirubin (nBR) would improve uptake by murine pancreatic islet cells and improve their viability following hypoxic stress. Read More

    A case of long-survival insulinoma with multiple neuroendocline tumour type 1 controlled by multimodal therapy.
    J Surg Case Rep 2017 Dec 11;2017(12):rjx244. Epub 2017 Dec 11.
    Department of Surgery, Institute of Gastroenterology, Tokyo Woman's Medical University, Tokyo, Japan.
    Insulinomas with multiple neuroendocrine tumour type 1 (MEN1) sometimes have metachronous or recurrent tumours. However, the treatment for these tumours is controversial, and published reports regarding multimodal therapy for insulinomas are limited. We report a 73-year-old woman with recurrent insulinoma with MEN1 successfully controlled by multimodal therapy. Read More

    Spirulina Extract Enhanced a Protective Effect in Type 1 Diabetes by Anti-Apoptosis and Anti-ROS Production.
    Nutrients 2017 Dec 15;9(12). Epub 2017 Dec 15.
    Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University, Seongnam 13135, Korea.
    Interest in the nutritional value and pharmacological activities of blue-green algae has gradually increased. Spirulina extracts show protective effects against apoptosis and inflammatory damage in various cell types. Here, we investigated the protective effects of extracts from Spirulina maxima in a cytokine-mediated type 1 diabetes model in vitro and in streptozotocin-induced diabetic Wistar rats in vivo. Read More

    A severe but reversible reduction in insulin sensitivity is observed in patients with insulinoma.
    Ann Endocrinol (Paris) 2017 Dec 11. Epub 2017 Dec 11.
    Department of Endocrinology, Université catholique de Louvain, Cliniques Universitaires Saint-Luc, avenue Hippocrate 10, 1200 Brussels, Belgium.
    Background: Hypoglycemic manifestations are highly variable in patients with an insulinoma and largely independent of tumour size and severity of insulin hypersecretion.

    Objectives: We investigated the clinical, biological and tumoral characteristics of insulinomas in a large monocentric series of patients and we evaluated their insulin sensitivity before and after successful pancreatic surgery.

    Patients And Methods: This was a retrospective analysis of 40 patients treated for an insulinoma between 1982 and 2012 in our academic hospital. Read More

    Effects of vaspin on pancreatic β cell secretion via PI3K/Akt and NF-κB signaling pathways.
    PLoS One 2017 14;12(12):e0189722. Epub 2017 Dec 14.
    Department of Endocrinology, Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
    Vaspin (visceral adipose tissue-derived serine protease inhibitor) is a recently discovered adipokine that has been implicated in diabetes mellitus and other metabolic disorders. However, the effects of vaspin on pancreatic β cell function and related mechanisms are not fully understood. Thus, the present study was performed to investigate the effects of vaspin on pancreatic β cell function and the potential underlying mechanisms. Read More

    Assessment of Response to Treatment and Follow-Up in Gastroenteropancreatic Neuroendocrine Neoplasms.
    Endocr Metab Immune Disord Drug Targets 2017 Dec 13. Epub 2017 Dec 13.
    University Hospital - Endocrine Oncology Uppsala. Sweden.
    Well-established criteria for evaluating the response to treatment and the appropriate follow-up of individual patients are critical in clinical oncology. The current evidence-based data on these issues in terms of the management of gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are unfortunately limited. This document by the Italian Association of Clinical Endocrinologists (AME) on the criteria for the follow-up of GEP-NEN patients is aimed at providing comprehensive recommendations for everyday clinical practice based on both the best available evidence and the combined opinion of an interdisciplinary panel of experts. Read More

    The comprehensive electrophysiological study of curcuminoids on delayed-rectifier K+ currents in insulin-secreting cells.
    Eur J Pharmacol 2018 Jan 7;819:233-241. Epub 2017 Dec 7.
    Department of Physiology, National Cheng Kung University Medical College, Tainan 701, Taiwan. Electronic address:
    Curcumin (CUR) has been demonstrated to induce insulin release from pancreatic β-cells; however, how curcuminoids (including demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC)) exert any possible effects on membrane ion currents inherently in insulin-secreting cells remains largely unclear. The effects of CUR and other structurally similar curcuminoids on ion currents in rat insulin-secreting (INS-1) insulinoma cells were therefore investigated in this study. The effects of these compounds on ionic currents and membrane potential were studied by patch-clamp technique. Read More

    Stimulation of B-Raf increases c-Jun and c-Fos expression and upregulates AP-1-regulated gene transcription in insulinoma cells.
    Mol Cell Endocrinol 2017 Dec 8. Epub 2017 Dec 8.
    Department of Medical Biochemistry and Molecular Biology, Saarland University Medical Faculty, D-66421 Homburg, Germany. Electronic address:
    Stimulation of pancreatic β-cells with glucose activates the protein kinases B-Raf and extracellular signal-regulated protein kinase that participate in glucose sensing. Inhibition of both kinases results in impairment of glucose-regulated gene transcription. To analyze the signaling pathway controlled by B-Raf, we expressed a conditionally active form of B-Raf in INS-1 insulinoma cells. Read More

    Multi-disciplinary management of refractory insulinomas.
    Clin Endocrinol (Oxf) 2017 Dec 4. Epub 2017 Dec 4.
    Obesity and Endocrinology Research Group, University Hospital Aintree, UK.
    Insulinomas are predominantly benign (~90%), pancreatic neuroendocrine tumours characterised by hyperinsulinaemic hypoglycaemia. They usually present as a small (<2cm), well demarcated, solitary nodule that can arise in any part of the organ. Treatment of sporadic insulinomas is generally aimed at curative surgical resection with special consideration in genetic syndromes. Read More

    Nfe2l1 silenced insulinoma cells acquire aggressiveness and chemo-resistance.
    Endocr Relat Cancer 2017 Dec 4. Epub 2017 Dec 4.
    J Pi, Program of Environmental Toxicology, School of Public Health, China Medical University, Shenyang, China
    The transcription factor nuclear factor erythroid 2 like 1 (NFE2L1 or NRF1) is involved in various critical cell processes such as maintenance of ubiquitin-proteasome system and regulation of the cellular antioxidant response. We previously determined that pancreatic β-cell-specific Nfe2l1-knockout mice had hyperinsulinemia, and that silencing of Nfe2l1 in mouse islets or MIN6 insulinoma β-cells induced elevated basal insulin release and altered glucose metabolism. Hypoglycemia is a major issue with aggressive insulinomas, although a role of NFE2L1 in this pathology is not defined. Read More

    Insulinoma and Chronic Kidney Disease: An Uncommon Conundrum Not to Be Overlooked.
    Clin Med Insights Endocrinol Diabetes 2017 20;10:1179551417742620. Epub 2017 Nov 20.
    Department of Internal Medicine, Galliera Hospital, Genova, Italy.
    A hypertensive man with chronic kidney disease (CKD) secondary to polycystic disease was hospitalized for symptoms related to hypoglycemia. Fasting test elicited symptomatic hypoglycemia after 12 hours, which was associated with inappropriately unsuppressed normal insulin and C-peptide levels. Neither ultrasonography (US) nor magnetic resonance imaging detected any pancreatic tumor. Read More

    A subclass of serum anti-ZnT8 antibodies directed to the surface of live pancreatic β-cells.
    J Biol Chem 2018 Jan 28;293(2):579-587. Epub 2017 Nov 28.
    From the Department of Physiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205,
    The islet-specific zinc transporter ZnT8 is a major self-antigen found in insulin granules of pancreatic β-cells. Frequent insulin secretion exposes ZnT8 to the cell surface, but the humoral antigenicity of the surface-displayed ZnT8 remains unknown. Here we show that a membrane-embedded human ZnT8 antigen triggered a vigorous immune response in ZnT8 knock-out mice. Read More

    Surgical Therapy of Sporadic Pancreatic Neuroendocrine Neoplasias G1/G2.
    Visc Med 2017 Oct 4;33(5):344-350. Epub 2017 Oct 4.
    Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital Marburg, Marburg, Germany.
    Background: Pancreatic neuroendocrine neoplasias (pNENs) are uncommon but fascinating tumors with an annual incidence of 1 per 100,000 people. pNENs present either as functional tumors, causing specific hormonal syndromes like Zollinger-Ellison syndrome (ZES) or organic hyperinsulinism, or as non-functional pancreatic tumors (NF-pNENs). The natural history of pNENs is highly variable. Read More

    Notch pathway inhibition targets chemoresistant insulinoma cancer stem cells.
    Endocr Relat Cancer 2018 Feb 24;25(2):131-144. Epub 2017 Nov 24.
    Royal (Dick) School of Veterinary Studies and The Roslin InstituteUniversity of Edinburgh, Midlothian, UK.
    Insulinomas (INS) are the most common neuroendocrine pancreatic tumours in humans and dogs. The long-term prognosis for malignant INS is still poor due to a low success rate of the current treatment modalities, particularly chemotherapy. A better understanding of the molecular processes underlying the development and progression of INS is required to develop novel targeted therapies. Read More

    Safety and efficacy of autoantigen-specific therapy with 2 doses of alum-formulated glutamate decarboxylase in children with multiple islet autoantibodies and risk for type 1 diabetes: A randomized clinical trial.
    Pediatr Diabetes 2017 Nov 24. Epub 2017 Nov 24.
    Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida.
    Objective: Treatments have failed to delay or stop the autoimmune process, preceding onset of type 1 diabetes. We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was safe and affected progression to type 1 diabetes in children with islet autoimmunity.

    Methods: In an investigator-initiated, double-blind, placebo-controlled clinical trial, non-diabetic children aged 4 to 17. Read More

    Construction of a novel vaccine by conjugating a B-cell epitope of DPP4 to peptide IA2(5)-P2-1 to significantly control type 1 diabetes in NOD mice.
    Vaccine 2017 Dec 21;35(51):7187-7197. Epub 2017 Nov 21.
    School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:
    Type 1 diabetes is a chronic organ-specific autoimmune disease in which selective destruction of insulin-producing β cells leads to impaired glucose metabolism and its attendant complications. IA2(5)P2-1, a potent immunogenic carrier which designed by our laboratory, can induce high titer specific antibodies when carry a B cell epitope, such as B cell epitopes of DPP4, xanthine oxidase, and Urate transporter protein. In this report, we describe a novel multi-epitope vaccine composing a peptide of DPP4, an anti-diabetic B epitope of Insulinoma antigen-2(IA-2) and a Th2 epitope (P2:IPALDSLTPANED) of P277 peptide in human heat shock protein 60 (HSP60). Read More

    The Value of Hybrid Angio-CT in Preoperative Detection and Localization of Insulinomas: A Single-Center Retrospective Study.
    Cardiovasc Intervent Radiol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Interventional Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, People's Republic of China.
    Objective: To investigate the performance of hybrid angio-CT in preoperative detection and localization for insulinomas.

    Methods: Fifty-four postoperative pathology-confirmed patients from April 2015 to March 2017 were retrospectively reviewed; all patients underwent angio-CT with administration of contrast media in SMA, GDA and SA due to negative, inconclusive or controversial findings by several preoperative diagnostic methods including TAUS, CEUS, EUS, ECT, EMRI and DSA. Surgery was used as gold standard for localization of insulinomas; detection sensitivity and localization accuracy of angio-CT were assessed and compared with other preoperative image options. Read More

    Selective Arterial Calcium Stimulation with Hepatic Venous Sampling in Patients with Recurrent Endogenous Hyperinsulinemic Hypoglycemia and Metastatic Insulinoma: Evaluation in Five Patients.
    J Vasc Interv Radiol 2017 Dec;28(12):1745-1749
    Department of Radiology, Mayo Clinic School of Medicine, 200 1st St. SW, Rochester, MN 55905.
    Selective arterial calcium stimulation (SACST) with hepatic venous sampling was performed in 5 patients (3 female, 2 male; age range, 53-73 y) with recurrent endogenous hyperinsulinemic hypoglycemia caused by metastatic insulinoma between January 2004 and December 2014. The biochemical results of SACST confirmed functional hepatic metastases alone (n = 3), peripancreatic lymph-node and hepatic metastases (n = 1), and occult insulinoma in the pancreatic bed (n = 1), thereby helping to guide management. SACST may be useful to determine the extent of functional metastatic insulinoma, particularly within the liver, and may provide clinicians with additional information to help guide the multidisciplinary management of patients with recurrent endogenous hyperinsulinemic hypoglycemia. Read More

    Insulinoma-associated 1: A novel nuclear marker in Merkel cell carcinoma (cutaneous neuroendocrine carcinoma).
    J Cutan Pathol 2018 Feb 17;45(2):129-135. Epub 2017 Dec 17.
    Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics, Madison, Wisconsin.
    Merkel cell carcinoma (MCC) is a rare, clinically aggressive, cutaneous neuroendocrine (NE) neoplasm. As a tumor with small, round, blue cells, the histologic differential diagnosis for MCC can include melanoma, metastatic small cell carcinoma (SCC), nodular hematopoietic tumors, basal cell carcinoma (BCC), atypical variants of squamous carcinoma and the uncommon occurrence of primary cutaneous Ewing sarcoma. In cases with atypical histology or without the classic immunophenotype, the diagnosis can be challenging. Read More

    Investigation of Antihyperglycaemic Activity of Banana (Musa sp. Var. Nanjangud rasa bale) Flower in Normal and Diabetic Rats.
    Pharmacogn Mag 2017 Oct 11;13(Suppl 3):S417-S423. Epub 2017 Oct 11.
    Department of Biotechnology, Sri Jayachamarajendra College of Engineering, JSS Institution Camp, Manasagangothri, Mysore, Karnataka, India.
    Background: The vital enzymes of starch digestion and absorption are intestinal α-glucosidases and their inhibition improves postprandial hyperglycaemia, constituting an effective mode of therapy in diabetes.

    Objectives: The present study was designed to assess the inhibitory potential of ethanol extract of banana flower (EF) on mammalian α-glucosidases and its pharmacological effects on postprandial hyperglycaemia in normal and alloxan-induced diabetic rats.

    Materials And Methods: EF was evaluated for its inhibitory potential and mode of inhibition on mammalian α-glucosidases. Read More

    EUS-guided lauromacrogol ablation of insulinomas: a novel treatment.
    Scand J Gastroenterol 2017 Nov 16:1-5. Epub 2017 Nov 16.
    a Department of Gastroenterology , First Affiliated Hospital of Guangxi Medical University , Nanning , P.R. China.
    Background And Aims: EUS-guided ablation with ethanol has been used to treat insulinoma since 2006 as a minimally invasive alternative for those who are unwilling or unsuitable for surgeries. However, pancreatic fistula, pancreatitis and other adverse effects were found after the procedure in these patients. Herein, we aimed to find a novel feasible injection. Read More

    '25-Hydroxyvitamin D, Autoantigenic and Total Antibody Concentrations: Results from a Danish Case-control Study of Newly Diagnosed Patients with Childhood Type 1 Diabetes and their Healthy Siblings'.
    Scand J Immunol 2018 Jan 12;87(1):46-53. Epub 2017 Dec 12.
    Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Paediatrics, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
    B cells have recently entered the stage as an important accessory player in type 1 diabetes (T1D) etiopathogenesis. Experimental studies suggest regulatory functions of vitamin D on B cells. However, only a few human studies, with considerable methodological limitations, have been conducted within this field. Read More

    First experience of robotic spleen-preserving distal pancreatectomy in a child with insulinoma.
    World J Surg Oncol 2017 Nov 9;15(1):199. Epub 2017 Nov 9.
    Department of Surgical Oncology (HBP), Chinese PLA General Hospital, Beijing, 100853, China.
    Background: An insulinoma is a functional neuroendocrine pancreatic tumor, and surgical resection is indicated. Robot-assisted laparoscopic surgeries have been shown to be generally safe and feasible for treatment of pediatric cases of urologic and digestive disease.

    Case Presentation: In July 2016, a 9-year-old girl (24 kg, 120 cm) was admitted with a pancreatic tail insulinoma and underwent robot-assisted spleen-preserving laparoscopic distal pancreatectomy. Read More

    Novel recurrence risk stratification of resected pancreatic neuroendocrine tumor.
    Cancer Lett 2018 Jan 26;412:188-193. Epub 2017 Oct 26.
    Shanghai Pancreatic Cancer Institute, Shanghai 200032, PR China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, PR China; Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 20032, PR China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, PR China. Electronic address:
    Radical surgical resection represents the only hope of cure for pancreatic neuroendocrine tumor (PanNET). Adjuvant therapy is rarely used because there is no evidence to distinguish patients with high recurrence risk. Here we investigated the recurrence feature of resected PanNET and established a novel risk stratification to predict its recurrence. Read More

    [Early endocrine neoplasia of the pancreas].
    Chirurg 2017 Nov 2. Epub 2017 Nov 2.
    Klinik für Visceral‑, Thorax- und Gefäßchirurgie, Standort Marburg, Universitätsklinikum Gießen und Marburg GmbH, Marburg, Deutschland.
    Pancreatic endocrine neoplasias (pNENs) are uncommon but fascinating tumors with a rising incidence. In accordance to its location, size and grading, the decision to operate the patient should always be made in an interdisciplinary approach. This article provides a comprehensive review of the current literature addressing the current challenges in pNEN surgery and shows that patients with completely resected small pNENs generally have an excellent prognosis, but also that surveillance may be a powerful tool. Read More

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