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    Autoantibodies against islet cell antigens in children with type 1 diabetes mellitus.
    Oncotarget 2018 Mar 19;9(23):16275-16283. Epub 2018 Feb 19.
    Department of Pediatric Endocrinology, MacKay Children's Hospital, Taipei, Taiwan.
    We investigated the prevalence of glutamic acid decarboxylase 65 autoantibody (GADA), insulinoma-associated protein 2 autoantibody (IA2A), and insulin autoantibody (IAA) in 750 children with type 1 diabetes (T1D) living in Taiwan. GADA, IA2A, and IAA were measured by radioimmunoassay. The data were assessed by test, binary logistic regression, and Spearman rank correlation. Read More

    Rare malignant insulinoma with multiple liver metastases derived from ectopic pancreas: 3-year follow-up and literature review.
    Onco Targets Ther 2018 3;11:1813-1819. Epub 2018 Apr 3.
    Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China.
    Here, we report the diagnosis and treatment of a very rare case of malignant insulinoma derived from ectopic pancreas. A middle-aged woman presented with a 6-year history of recurrent hypoglycemia with multiple lesions in liver. Admission workup revealed elevated serum insulin and C-peptide, as well as multiple lesions in the liver (largest being 4. Read More

    [A case of insulinoma complicated with secondary adrenal insufficiency].
    Zhejiang Da Xue Xue Bao Yi Xue Ban 2017 May;46(6):662-665
    Department of Endocrinology, the Second Hospital of Lanzhou University, Lanzhou 730030, China.
    A middle-aged male patient with recurrent hypoglycemia was diagnosed as insulinoma according to the symptoms and the laboratory tests. Laboratory tests also showed low cortisol and adrenocortico-tropic hormone (ACTH) levels, therefore adrenal insufficiency was diagnosed and hydrocortisone was given. The hormone replacement therapy was terminated after surgery, and ACTH and cortisol levels returned to normal. Read More

    Modifying Enzymes are Elicited by ER Stress, Generating Epitopes that are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes.
    Diabetes 2018 Apr 13. Epub 2018 Apr 13.
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101 USA.
    In spite of tolerance mechanisms, some individuals develop T cell mediated autoimmunity. Post-translational modifications that increase the affinity of epitope presentation and/or recognition represent one means through which self-tolerance mechanisms can be circumvented. We investigated T cell recognition of peptides that correspond to modified beta cell antigens in subjects with type 1 diabetes. Read More

    [Surgical strategies for small sporadic neuroendocrine pancreatic tumors].
    Chirurg 2018 Apr 10. Epub 2018 Apr 10.
    Sektionsleitung Endokrine Chirurgie, Klinik für Viszeral‑, Thorax- und Gefäßchirurgie, Universitätsklinikum Marburg, Baldingerstraße, 35043, Marburg, Deutschland.
    Small (<2 cm) sporadic neuroendocrine pancreatic neoplasms (pNENs) are a heterogeneous group of neoplasms, which can be separated into functionally active or non-functional tumors. Functionally active pNENs release various hormones, such as insulin, gastrin, glucagon and vasoactive intestinal hormones and therefore lead to severe symptoms independent of their size. The main symptoms include hypoglycemia, coma (insulinoma), diarrhea (gastrinoma, VIPoma), intestinal ulcers (gastrinoma) and hyperglycemia (glucagonoma). Read More

    Diagnostic challenges in a patient with an occult insulinoma:Ga-DOTA-exendin-4 PET/CT and Ga-DOTATATE PET/CT.
    Clin Case Rep 2018 Apr 1;6(4):719-722. Epub 2018 Mar 1.
    Department of Endocrinology & DiabetesSt Vincent's HospitalMelbourneVictoriaAustralia.
    Despite growing evidence for GLP-1R molecular-based imaging, successful localization of insulinomas may require the use of multiple imaging modalities. Not all benign insulinomas express the GLP-1R as expected. Our case demonstrates that there is a still an important role for traditional methods for the anatomical localization of an insulinoma. Read More

    Management of functional neuroendocrine tumors of the pancreas.
    Gland Surg 2018 Feb;7(1):20-27
    Department of Medical Sciences, Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden.
    Pancreatic neuroendocrine tumors (pNETs) constitute a heterogenous group of malignancies with varying clinical presentation, tumor biology and prognosis. The incidence of pNETs has steadily increased during the last decades with an estimated incidence 2012 of 4.8/100,000. Read More

    Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells.
    Biochim Biophys Acta 2018 Apr 5. Epub 2018 Apr 5.
    Department of Biological Sciences, The George Washington University, Washington, DC 20052, USA. Electronic address:
    Misfolded toxic human islet amyloid polypeptide or amylin (hA) and plasma membrane-associated redox complex, NADPH oxidase (NOX), have been implicated in the islet β-cell demise associated with type-2 diabetes mellitus (T2DM). Studies show that hA accumulation is stressful to β-cells and that misfolding of human amylin evokes redox stress and activates mitogen activated protein (MAP) kinases, p38 MAPK and c-Jun N-terminal (JNK) kinase. However, the molecular link and causality between hA-evoked redox stress, NOX activity and MAP kinases signaling in pancreatic β-cells is incompletely understood. Read More

    Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice.
    J Endocr Soc 2018 Mar 30;2(3):207-219. Epub 2018 Jan 30.
    Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
    The proliferation of pancreatic cells is enhanced to enable an increase in -cell mass and to compensate for insulin resistance during pregnancy. To elucidate the mechanisms involved, we previously investigated islets from pregnant and nonpregnant mice by gene expression profiling and found that the expression of postsynaptic density-95/Discs large/zonula occludens-1 (PDZ)-binding kinase (Pbk), a member of the mitogen-activated protein kinase kinase family, is increased in pregnant mouse islets compared with control mouse islets. Among the pregnancy hormones, treatment with estradiol upregulated expression. Read More

    [Multidisciplinary approach to surgical disorders of the pancreas in children].
    Rozhl Chir 2018 ;97(3):109-116
    Introduction: Surgical diseases of the pancreas in children are not common and may be associated with significant morbidity and potential mortality. A multidisciplinary approach is essential for correct diagnosis, surgical strategy and postoperative as well as follow-up care.

    Method: Retrospective analysis of patients operated on due to a pathological lesion of the pancreas focused on diagnostics, operating procedures, postoperative complications, and long-term results. Read More

    Pioglitazone Attenuates Palmitate-Induced Inflammation and Endoplasmic Reticulum Stress in Pancreatic β-Cells.
    Endocrinol Metab (Seoul) 2018 Mar;33(1):105-113
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background: The nuclear receptor peroxisome proliferator-activator gamma (PPARγ) is a useful therapeutic target for obesity and diabetes, but its role in protecting β-cell function and viability is unclear.

    Methods: To identify the potential functions of PPARγ in β-cells, we treated mouse insulinoma 6 (MIN6) cells with the PPARγ agonist pioglitazone in conditions of lipotoxicity, endoplasmic reticulum (ER) stress, and inflammation.

    Results: Palmitate-treated cells incubated with pioglitazone exhibited significant improvements in glucose-stimulated insulin secretion and the repression of apoptosis, as shown by decreased caspase-3 cleavage and poly (adenosine diphosphate [ADP]-ribose) polymerase activity. Read More

    Insulin Autoimmune Syndrome: a rare case of hypoglycaemia resolving with immunosuppression.
    Ulster Med J 2018 Jan 31;87(1):34-36. Epub 2018 Jan 31.
    Endocrinology and Diabetes, Mater Hospital, 47-51 Crumlin Rd, Belfast, BT14 6AB.
    We report a case of a 58-year-old male presenting with confusion and hypoglycaemia. There had been no prior exposure to oral hypoglycaemic agents or insulin. He was found to have inappropriate endogenous hyperinsulinaemia. Read More

    Scopoletin intervention in pancreatic endoplasmic reticulum stress induced by lipotoxicity.
    Cell Stress Chaperones 2018 Mar 25. Epub 2018 Mar 25.
    Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Tamil Nadu, 608002, India.
    Endoplasmic reticulum (ER), a dynamic organelle, plays an essential role in organizing the signaling pathways involved in cellular adaptation, resilience, and survival. Impairment in the functions of ER occurs in a variety of nutritive disorders including obesity and type 2 diabetes. Here, we hypothesize that (scopoletin) SPL, a coumarin, has the potential to alleviate ER stress induced in vitro and in vivo models by lipotoxicity. Read More

    Puerarin promotes MIN6 cell survival by reducing cellular reactive oxygen species.
    Mol Med Rep 2018 May 14;17(5):7281-7286. Epub 2018 Mar 14.
    Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China.
    Type 1 diabetes is caused by destruction of the pancreatic β‑cells and, to date, no cure has been developed. Promoting the survival of pancreatic β‑cells may be beneficial for patients with type 1 diabetes. Puerarin is an estrogen analogue that been demonstrated in previous studies to be able to decreased blood glucose in patients with type 1 diabetes. Read More

    Overexpression of appoptosin promotes mitochondrial damage in MIN6 cells.
    Mol Med Rep 2018 May 16;17(5):7149-7155. Epub 2018 Mar 16.
    Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China.
    Damage to pancreatic β‑cells is closely associated with diabetes. However, the mechanism underlying injury to pancreatic β‑cells remains unclear, although hypoxia is considered as one of the leading causes. Appoptosin is a mitochondrial protein that promotes neuronal apoptosis. Read More

    Hyperinsulinemic hypoglycemia without insulinoma: Think of activating glucokinase mutation.
    Presse Med 2018 Mar 16. Epub 2018 Mar 16.
    Lille University Hospital, C. Huriez Hospital, Endocrinology and Metabolism Department, 1, rue Polonovski, 59037 Lille cedex, France; INSERM U1190 Translational Research in Diabetes, 59037 Lille, France; E.G.I.D - FR3508 European Genomic Institute for Diabetes, 59037 Lille, France. Electronic address:

    Endothelial and beta cell composite aggregates for improved function of a bioartificial pancreas encapsulation device.
    Int J Artif Organs 2018 Mar 20;41(3):152-159. Epub 2018 Feb 20.
    1 Bioartificial Organs, Biomaterials Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands.
    Introduction: Encapsulation of pancreatic islets or beta cells is a promising strategy for treatment of type 1 diabetes by providing an immune isolated environment and allowing for transplantation in a different location than the liver. However, islets used for encapsulation often show lower functionality due to the damaging of islet endothelial cells during the isolation procedure. Factors produced by endothelial cells have great impact on beta cell insulin secretion. Read More

    Pseudo-hemorrhagic region formation in pancreatic neuroendocrine tumors is a result of blood vessel dilation followed by endothelial cell detachment.
    Oncol Lett 2018 Apr 22;15(4):4255-4261. Epub 2018 Jan 22.
    Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Chaoyang, Beijing 100029, P.R. China.
    Aberrant blood vessel formation and hemorrhage may contribute to tumor progression and are potential targets in the treatment of several types of cancer. Pancreatic neuroendocrine tumors (PNETs) are highly vascularized, particularly when they are well-differentiated. However, the process of vascularization and endothelial cell detachment in PNETs is poorly understood. Read More

    Improved Labeling of Pancreatic Islets Using Cationic Magnetoliposomes.
    J Pers Med 2018 Mar 12;8(1). Epub 2018 Mar 12.
    Biomedical MRI/MoSAIC, Department of Imaging and Pathology, University of Leuven, Herestraat 49, B3000 Leuven, Belgium.
    Pancreatic islets (PIs) transplantation is an alternative approach for the treatment of severe forms of type 1 diabetes (T1D). To monitor the success of transplantation, it is desirable to follow the location of engrafted PIs non-invasively. In vivo magnetic resonance imaging (MRI) of transplanted PIs is a feasible cell tracking method; however, this requires labeling with a suitable contrast agent prior to transplantation. Read More

    Usefulness of four-dimensional flow-sensitive magnetic resonance imaging to evaluate hemodynamics in the pancreaticoduodenal artery.
    Clin J Gastroenterol 2018 Mar 5. Epub 2018 Mar 5.
    Second Department of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.
    Pancreaticoduodenal artery (PDA) aneurysm associated with celiac axis compression by the median arcuate ligament (MAL) is a rare disorder, but may be lethal if ruptured. Therefore, prophylactic surgical treatments need to be considered when MAL compresses the celiac axis. We herein report the usefulness of an arterial flow analysis for objectively evaluating this pathophysiology under four-dimensional flow-sensitive magnetic resonance imaging (4D-flow MRI). Read More

    IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells.
    J Cell Biol 2018 Apr 5;217(4):1287-1301. Epub 2018 Mar 5.
    Graduate School of Biological Sciences and Institute for Research Initiatives, Nara Institute of Science and Technology, Ikoma, Japan
    In mammalian pancreatic β cells, the IRE1α-XBP1 pathway is constitutively and highly activated under physiological conditions. To elucidate the precise role of this pathway, we constructed β cell-specific conditional knockout (CKO) mice and established insulinoma cell lines in which was deleted using the Cre-loxP system. CKO mice showed the typical diabetic phenotype including impaired glycemic control and defects in insulin biosynthesis postnatally at 4-20 weeks. Read More

    Radiosynthesis and evaluation of an F-labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma.
    EJNMMI Radiopharm Chem 2018 2;3(1). Epub 2018 Jan 2.
    2Center for Radiopharmaceutical Sciences (CRS), Research Department Biology and Chemistry, Paul Scherrer Institut, CH-5232 Villigen, Switzerland.
    Background: Analogues of exendin-4 have been radiolabeled for imaging the glucagon-like peptide type 1 receptors (GLP-1R) which are overexpressed in insulinoma. The aim of this research was to synthesize an F-labeled silicon containing exendin-4 peptide (F-) and to evaluate its in vitro and behavior in CHL-GLP-1 receptor positive tumor-bearing mice. F-labeled silicon containing exendin-4 peptide (F-) was prepared via one-step nucleophilic substitution of a silane precursor with F-fluoride in the presence of acetic acid and K222. Read More

    Liquiritigenin prevents palmitate-induced beta-cell apoptosis via estrogen receptor-mediated AKT activation.
    Biomed Pharmacother 2018 May 22;101:348-354. Epub 2018 Mar 22.
    Department of Food and Nutrition, Eulji University, Seongnam, South Korea. Electronic address:
    Liquiritigenin (LQ) is a major active component of licorice root, which is a flavone used for treating many diseases, including diabetes. LQ has been shown to exhibit a glucose-lowering effect in diabetic mice. Therefore, we investigated the potential of LQ to protect against lipotoxicity-induced beta-cell apoptosis and the underlying molecular mechanisms. Read More

    INSM1 Expression Is Frequent in Primary Central Nervous System Neoplasms but Not in the Adult Brain Parenchyma.
    J Neuropathol Exp Neurol 2018 May;77(5):374-382
    Division of Neuropathology, Department of Pathology.
    Tumors with a neuronal component comprise a small percentage of central nervous system (CNS) neoplasms overall, but the presence of neuronal differentiation has important diagnostic, prognostic, and therapeutic implications. Insulinoma-associated protein 1 (INSM1) is a transcription factor with strong nuclear immunostaining in neuroendocrine cells and neoplasms of neuroendocrine origin; however, its expression in the CNS in normal brain and in neoplastic cells has not been fully explored. Here, we present immunostaining results from a large number of archival CNS tissue specimens, including 416 tumors. Read More

    Streptozotocin-Induced Autophagy Reduces Intracellular Insulin in Insulinoma INS-1E Cells.
    DNA Cell Biol 2018 Mar 27;37(3):160-167. Epub 2018 Feb 27.
    2 Division of Forest Science, Institute of Forest Science, College of Forest and Environmental Sciences , Kangwon National University, Chuncheon, Gangwon-do, Republic of Korea.
    Streptozotocin (STZ), a glucose analog, induces diabetes in experimental animals by inducing preferential cytotoxicity in pancreatic beta cells. We investigated whether STZ reduced the production of intracellular insulin through autophagy in insulinoma INS-1E cells. Typically, 2 mM STZ treatment for 24 h significantly decreased cell survival. Read More

    4-Methylcatechol stimulates apoptosis and reduces insulin secretion by decreasing betacellulin and inhibin beta-A in INS-1 beta-cells.
    Hum Exp Toxicol 2018 Jan 1:960327118758365. Epub 2018 Jan 1.
    Istanbul University, Faculty of Science, Department of Biology, Istanbul, Turkey.
    Insulinoma INS-1 cell line is a pancreatic beta cell tumor which is characterized with high insulin content and secretion in response to increasing glucose levels. 4-Methylcatechol (4-MC) is a metabolite of quercetin, which is known as a potential drug for inhibition of tumorigenesis. The aim of this study was to determine the applying doses of 4-methylcatechol (4-MC) for triggening cell death and decreasing the cell function of rat insulinoma INS-1 beta cells. Read More

    Insulinoma: A retrospective study analyzing the differences between benign and malignant tumors.
    Pancreatology 2018 Apr 1;18(3):298-303. Epub 2018 Feb 1.
    Unidade de Endocrinologia Geral, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Brazil.
    Background/objectives: Insulinoma is a rare pancreatic tumor and, usually, a benign disease but can be a malignant one and, sometimes, a highly aggressive disease. The aim of this study was to determine differences between benign and malignant tumors.

    Methods: Retrospective study of 103 patients with insulinoma treated in a tertiary center. Read More

    Sprouting angiogenesis in engineered pseudo islets.
    Biofabrication 2018 Mar 16;10(3):035003. Epub 2018 Mar 16.
    The Huck Institutes of the Life Sciences, Penn State University, State College, PA 16801, United States of America. Department of Agriculture and Biological Engineering, Penn State University, State College, PA 16801, United States of America.
    Despite the recent achievements in cell-based therapies for curing type-1 diabetes (T1D), capillarization in beta (β)-cell clusters is still a major roadblock as it is essential for long-term viability and function of β-cells in vivo. In this research, we report sprouting angiogenesis in engineered pseudo islets (EPIs) made of mouse insulinoma βTC3 cells and rat heart microvascular endothelial cells (RHMVECs). Upon culturing in three-dimensional (3D) constructs under angiogenic conditions, EPIs sprouted extensive capillaries into the surrounding matrix. Read More

    Imaging features of malignant abdominal neuroendocrine tumors with rare presentation.
    Clin Imaging 2018 Feb 8;51:59-64. Epub 2018 Feb 8.
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:
    Background: Gastroenteropancreatic neuroendocrine tumors (NETs) are rare entities arising from neuroendocrine cells in the gastroenteric tract and pancreas. The purpose of this article is to present four cases of gastroenteropancreatic NETs that featured a challenging diagnosis.

    Case Presentation: We report a case series of four NETs, each with different features. Read More

    INSM1 is a Sensitive and Specific Marker of Neuroendocrine Differentiation in Head and Neck Tumors.
    Am J Surg Pathol 2018 May;42(5):665-671
    Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY.
    The head and neck is the site of a wide and sometimes bewildering array of neuroendocrine (NE) tumors. Although recognition of NE differentiation may be necessary for appropriate tumor classification and treatment, traditional NE markers such as synaptophysin, chromogranin, and CD56 are not always sufficiently sensitive or specific to make this distinction. Insulinoma-associated protein 1 (INSM1) is a novel transcription factor that has recently demonstrated excellent sensitivity and specificity for NE differentiation in various anatomic sites, but has not yet been extensively evaluated in tumors of the head and neck. Read More

    17β-estradiol protects INS-1 insulinoma cells from mitophagy via G protein-coupled estrogen receptors and the PI3K/Akt signaling pathway.
    Int J Mol Med 2018 May 7;41(5):2839-2846. Epub 2018 Feb 7.
    Department of Orthopedic Surgery, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R. China.
    17β-estradiol (17β-E2) is a steroid hormone that is known to exert effects on blood glucose homeostasis. The G protein‑coupled estrogen receptor (GPER) has been identified as a non-genomic estrogenic receptor, and is involved in numerous physiological processes, including cell survival, energy provision and metabolism. 17β-E2 may decrease apoptosis by binding to the GPER. Read More

    Two nonsense somatic mutations in identified in sporadic insulinomas.
    FEBS Open Bio 2018 Feb 2;8(2):295-301. Epub 2018 Jan 2.
    Department of Hepatobiiary SurgeryThe Second Hospital of Hebei Medical UniversityShijiazhuangChina.
    Insulinomas are functional pancreatic neuroendocrine tumors that cause hypoglycemia and severe morbidity. The aim of our study was to identify gene mutations responsible for tumorigenesis of sporadic insulinoma. Whole exome sequencing analysis was performed on tumors and paired peripheral blood from three patients with insulinomas. Read More

    Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation.
    Nat Commun 2018 02 9;9(1):612. Epub 2018 Feb 9.
    The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, 100730, China.
    Ultraconserved (uc) RNAs, a class of long non-coding RNAs (lncRNAs), are conserved across humans, mice, and rats, but the physiological significance and pathological role of ucRNAs is largely unknown. Here we show that uc.372 is upregulated in the livers of db/db mice, HFD-fed mice, and NAFLD patients. Read More

    Mesenchymal stem cell (MSC)-mediated survival of insulin producing pancreatic β-cells during cellular stress involves signalling via Akt and ERK1/2.
    Mol Cell Endocrinol 2018 Feb 5. Epub 2018 Feb 5.
    Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:
    Mesenchymal stem cells (MSC) are of interest for cell therapy since their secreted factors mediate immunomodulation and support tissue regeneration. This study investigated the direct humoral interactions between MSC and pancreatic β-cells using human telomerase-immortalized MSC (hMSC-TERT) and rat insulinoma-derived INS-1E β-cells. hMSC-TERT supported survival of cocultured INS-1E β-cells during cellular stress by alloxan (ALX) and streptozotocin (STZ), but not in response to IL-1β. Read More

    Stable Liquid Glucagon: Beyond Emergency Hypoglycemia Rescue.
    J Diabetes Sci Technol 2018 Feb 1:1932296818757795. Epub 2018 Feb 1.
    1 Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University, Portland, OR, USA.
    Glycemic control is the mainstay of preventing diabetes complications at the expense of increased risk of hypoglycemia. Severe hypoglycemia negatively impacts the quality of life of patients with type 1 diabetes and can lead to morbidity and mortality. Currently available glucagon emergency kits are effective at treating hypoglycemia when correctly used, however use is complicated especially by untrained persons. Read More

    Characterisation of the French ferret population, husbandry, reported medical care and feeding habits.
    J Nutr Sci 2018 31;7:e4. Epub 2018 Jan 31.
    CHV St Martin Bellevue, St Martin Bellevue, France.
    Ferrets have become a common companion animal. But no data are available on the French population of ferrets. The goal of the survey was to characterise this population, including demographic characteristics, husbandry, reported medical care and feeding habits. Read More

    Morphologically 'invisible' proinsulin - secreting adenoma detected by Ga-68 Exendin-4 (GLP-1 Receptor) positron emission tomography/CT.
    J Med Imaging Radiat Oncol 2018 Feb 5. Epub 2018 Feb 5.
    Division of Endocrinology and Metabolic Diseases, Clinic of Internal Medicine III, Jena University Hospital, Jena, Germany.
    This case report of a young man suffering from recurring hypoglycaemia illustrates a rare condition of a neuroendocrine tumour, predominantly secreting proinsulin and invisible to conventional imaging approaches. Only a GLP-1 receptor PET/CT using Exendin-4 visualized the pancreatic lesion and enabled curative therapy, confirming the diagnostic value of this tracer for detection of neuroendocrine tumours. As only few publications on this topic are available, an overview of the available data is also given. Read More

    Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1.
    Exp Ther Med 2018 Jan 30;15(1):576-584. Epub 2017 Oct 30.
    Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
    The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health problem and novel therapeutic strategies are required to prevent and treat T2DM. It has been demonstrated that resveratrol (RSV) may prevent T2DM by targeting Sirtuin type 1 (SIRT1), indicating that SIRT1 may be a novel therapeutic target for T2DM prevention. In the present study, a T2DM rat model was established by administering a high fat diet and streptozotocin (STZ) injections. Read More

    Insulinoma presenting with post-prandial hypoglycaemia following fundoplication.
    Endocrinol Diabetes Metab Case Rep 2018 18;2018. Epub 2018 Jan 18.
    Department of Endocrinology and Diabetes, The Alfred Hospital, Melbourne, Australia.
    Insulinomas are rare neuroendocrine tumours that classically present with fasting hypoglycaemia. This case report discusses an uncommon and challenging case of insulinoma soon after upper gastrointestinal surgery. A 63-year-old man presented with 6 months of post-prandial hypoglycaemia beginning after a laparoscopic revision of Toupet fundoplication. Read More

    Insulinoma-associated protein 1 is a sensitive and specific marker of neuroendocrine lung neoplasms in cytology specimens.
    Cancer Cytopathol 2018 Apr 23;126(4):243-252. Epub 2018 Jan 23.
    Department of Pathology, Cleveland Clinic, Cleveland, Ohio.
    Background: Recent studies suggest that insulinoma-associated protein 1 (INSM1) is a sensitive and specific marker of neuroendocrine neoplasms. The aims of this study were to determine whether INSM1 can be reliably used in cytology (Cellient) cell blocks, to ascertain whether staining correlates with paired surgical pathology specimens, and to compare its sensitivity and specificity with those of synaptophysin (SYN), chromogranin (CHR), and CD56 for neuroendocrine lung tumors.

    Methods: Seventy-four primary lung neoplasms diagnosed on cytology were stained with INSM1, SYN, CHR, and CD56: 41 small cell lung carcinomas (SCLCs), 1 large cell neuroendocrine carcinoma (LCNEC), 10 carcinoid tumors, 11 adenocarcinomas, 9 squamous cell carcinomas, 1 mesothelioma and 1 poorly differentiated non-small cell lung carcinoma, not otherwise specified. Read More

    Concurrent endocrine neoplasias in dogs and cats: a retrospective study (2004-2014).
    Vet Rec 2018 03 19;182(11):323. Epub 2018 Jan 19.
    Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
    Multiple endocrine neoplasia (MEN) is a well-known syndrome in human medicine, whereas only a few cases of concurrent endocrine neoplasias have been reported in dogs and cats. The aim of this study was to evaluate the prevalence of concurrent endocrine neoplasias in dogs and cats at our clinic, identify possible breed and sex predispositions and investigate similarities with MEN syndromes in humans. Postmortem reports of 951 dogs and 1155 cats that died or were euthanased at the Clinic for Small Animal Internal Medicine, University of Zurich, between 2004 and 2014 were reviewed, and animals with at least two concurrent endocrine neoplasias and/or hyperplasias were included. Read More

    Early Infant Diet and Islet Autoimmunity in the TEDDY Study.
    Diabetes Care 2018 Mar 17;41(3):522-530. Epub 2018 Jan 17.
    Objective: To examine duration of breastfeeding and timing of complementary foods and risk of islet autoimmunity (IA).

    Research Design And Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes (T1D) in the U.S. Read More

    missense mutation causes familial insulinomatosis and diabetes mellitus.
    Proc Natl Acad Sci U S A 2018 Jan 16;115(5):1027-1032. Epub 2018 Jan 16.
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, EX2 5DW Exeter, United Kingdom.
    The β-cell-enriched MAFA transcription factor plays a central role in regulating glucose-stimulated insulin secretion while also demonstrating oncogenic transformation potential in vitro. No disease-causing variants have been previously described. We investigated a large pedigree with autosomal dominant inheritance of diabetes mellitus or insulinomatosis, an adult-onset condition of recurrent hyperinsulinemic hypoglycemia caused by multiple insulin-secreting neuroendocrine tumors of the pancreas. Read More

    An observational analysis of insulinoma from 1 single institution.
    QJM 2018 Jan 8. Epub 2018 Jan 8.
    Division of Endocrinology, Tongji Hospital, Huazhong University of Science & Technology, Wuhan, PR China, 430030.
    Background: Insulinoma is the commonest functioning pancreatic neuroendocrine tumor causing hyperinsulinemic hypoglycemia. This study is aimed to evaluate the clinical features, preoperative laboratory and imaging diagnosis, and pathologic findings of insulinoma.

    Methods: Data of the patients from 2001 to 2016 diagnosed as insulinoma in Tongji Hospital, China were retrospectively extracted and analyzed. Read More

    Rare Cause of Recurrent Hypoglycemia: Insulin Autoimmune Syndrome.
    Case Rep Endocrinol 2017 26;2017:6423852. Epub 2017 Nov 26.
    Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    We report a case of insulin autoimmune syndrome associated with several autoantibodies, presenting with recurrent hypoglycemia, predominantly in the postprandial period, which improved by dietary management and spontaneously resolved within two months. Differentiation from other causes of hyperinsulinemic hypoglycemia, such as insulinoma, is important to avoid unnecessary invasive procedures or surgical interventions. The 75-gram oral glucose tolerance test (OGTT) and mixed meal test showed a typical pattern, which may be useful indirect evidence of insulin autoimmune syndrome. Read More

    A novel synthetic human insulin super promoter for targeting PDX-1-expressing pancreatic cancer.
    Cancer Lett 2018 Apr 6;418:75-83. Epub 2018 Jan 6.
    Department of Surgery, University of Toledo College of Medicine & Life Sciences, Toledo OH, USA. Electronic address:
    Our previous studies have shown that a rat insulin promoter II fragment (RIP) was used to effectively target pancreatic adenocarcinoma (PDAC) and insulinoma that over-express pancreatic and duodenal homeobox-1 (PDX-1). To enhance the activity and specificity of the human insulin promoter, we engineered a synthetic human insulin super-promoter (SHIP). Reporter assay demonstrated that SHIP1 was the most powerful promoter among all of the SHIPs and had far greater activity than the endogenous human insulin promoters and RIP in PDAC expressing PDX-1. Read More

    β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice.
    PLoS One 2018 5;13(1):e0190863. Epub 2018 Jan 5.
    Department of Health and Environmental Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    Adiponectin, a metabolically-active cytokine secreted from adipose tissue, is reported to have anti-apoptotic effects on β-cells as well as anti-hyperglycemic effects through adiponectin receptor signaling. However, the anti-apoptotic effects of adiponectin on β-cells have not been confirmed in established diabetic models, and the anti-hyperglycemic effects and their associated signal cascades remain controversial. To investigate the effects of adiponectin on β-cell protection and its down-stream signaling events, we have generated β-cell-specific rat insulin promoter (RIP)-AdipoR1 transgenic mice (AdipoR1 mice), in which the adiponectin receptor, AdipoR1, is overexpressed in β-cells in a manner synchronous with insulin demand. Read More

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