6,864 results match your criteria Insulinoma


Incidence and management of postoperative hyperglycemia in patients undergoing insulinoma resection.

Endocrine 2018 Jun 19. Epub 2018 Jun 19.

Department of Surgery, Surgery and Cancer Center, Stanford University School of Medicine, Stanford, CA, USA.

Purpose: It has been proposed that rebound hyperglycemia after resection of insulinoma indicates a biochemical cure. However, there is scant objective data in the literature on the rate and need for intervention in hyperglycemia in patients undergoing resection of insulinoma. The goal of our study was to evaluate the rate of postoperative hyperglycemia, any predisposing factors, and the need for intervention in a prospective cohort study of all patients undergoing routine glucose monitoring. Read More

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Robotic enucleation for pediatric insulinoma with MEN1 syndrome: a case report and literature review.

BMC Surg 2018 Jun 19;18(1):44. Epub 2018 Jun 19.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.

Background: A patient with a rare pediatric insulinoma and MEN1 syndrome was treated by robotic enucleation surgery.

Case Presentation: We present a case of a 9-year-old girl presenting with repeated loss of consciousness, concomitant with a pale face, palpitations, and convulsions, which had persisted for 2 years and had been aggravated during the previous 2 months. She was previously misdiagnosed with epilepsy in another hospital. Read More

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[Effects of iodine excess on islet β cells(β-TC-6) function and the mechanism].

Wei Sheng Yan Jiu 2017 Jul;46(4):610-614

School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China.

Objective: To explore the influences of iodine excess on insulin secret function of mouse insulinoma cells β-TC-6 and the mechanism.

Methods: β-TC-6 cells were treated with excessive iodine( Na I) in vitro. After 24 hour of exposure, the MTT assay was used to measure the cell viabilities. Read More

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July 2017
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A Plasmon-Enhanced Fluorescence Protein Microchip with High-Sensitivity for Multiple Islet Autoantibodies Measurements in Autoimmune Diabetes Diagnosis.

J Biomed Nanotechnol 2018 Aug;14(8):1496-1504

Correct classification diagnosis of diabetes is critical for timely and appropriate treatment, which partially depends on the multiple islet autoantibodies measurement and combined analysis. This study reports plasmon-enhanced fluorescence protein microchip method, a fast, high-throughput, and high sensitive method, to measure circulating islet autoantibodies. This method can achieve islet autoantibodies combined analysis within a few hours by using a few microliters of serum. Read More

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Recent Topics Around Multiple Endocrine Neoplasia Type 1.

Authors:
Stephen J Marx

J Clin Endocrinol Metab 2018 Apr;103(4):1296-1301

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is complex with regard to clinical expressions, management, and molecular pathways. Advances are being made broadly and in focused aspects. Selected topics are presented for their developments since publication of the most recent MEN1 consensus guidelines 6 years ago. Read More

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April 2018
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Insulinoma-associated protein 1 is a novel sensitive and specific marker for small cell carcinoma of the prostate.

Hum Pathol 2018 Jun 6. Epub 2018 Jun 6.

Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

The correct diagnosis of small cell carcinoma (SCC) of the prostate is critical because of its aggressive behavior and poor prognosis. The histopathologic diagnosis could be challenging without neuroendocrine markers, which currently has limitations. Insulinomaassociated protein 1 (INSM1), a zinc-finger transcription factor, is considered to play an important role in the development of several neuroendocrine precursor cells. Read More

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68Ga DOTA-Exendin PET/CT for Detection of Insulinoma in a Patient With Persistent Hyperinsulinemic Hypoglycemia.

Clin Nucl Med 2018 Jun 5. Epub 2018 Jun 5.

Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Insulinomas are the most common functioning pancreatic neuroendocrine tumors and the leading cause of persistent hypoglycemia with hyperinsulinemia in adults. Glucagon-like-peptide-1 (GLP) receptor analogs are the latest agents being used in the detection of insulinomas, with initial reports suggesting high sensitivity due to universal GLP1 receptor expression on these tumors. PET/CT imaging in this patient using Ga DOTA-Exendin, a GLP receptor analog, proved useful for accurate localization of the culprit lesion, aiding in the definitive management of the patient. Read More

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June 2018
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The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring.

Intern Med 2018 Jun 6. Epub 2018 Jun 6.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Graduate School of Medicine, Japan.

An 84-year-old Japanese woman with metastatic insulinoma suffered from frequent hypoglycemic events. Continuous glucose monitoring (CGM) confirmed severe and frequent symptomatic/asymptomatic hypoglycemia. After the initiation of everolimus treatment, the hypoglycemic events were rapidly eliminated. Read More

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Critical role for the Tsc1-mTORC1 pathway in β-cell mass in Pdx1 deficient mice.

J Endocrinol 2018 Jun 6. Epub 2018 Jun 6.

D Ren, Medicine, University of Chicago, Chicago, 60637, United States

Mutations in the pancreatic duodenal homeobox (PDX1) gene are associated with diabetes in humans. Pdx1-haploinsufficient mice also develop diabetes, but the molecular mechanism is unknown. To this end, we knocked down Pdx1 gene expression in mouse MIN6 insulinoma cells. Read More

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Peptidomic analysis of endogenous plasma peptides from patients with pancreatic neuroendocrine tumours.

Rapid Commun Mass Spectrom 2018 Jun 1. Epub 2018 Jun 1.

Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.

Rationale: Diagnosis of pancreatic neuroendocrine tumours requires the study of patient plasma with multiple immunoassays, using multiple aliquots of plasma. The application of mass spectrometry based techniques could reduce the cost and amount of plasma required for diagnosis.

Methods: Plasma samples from two patients with pancreatic neuroendocrine tumours were extracted using an established acetonitrile based plasma peptide enrichment strategy. Read More

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Akt/p27 Pathway Is Not Involved in Human Insulinoma Tumorigenesis.

Int J Endocrinol 2018 26;2018:7865072. Epub 2018 Apr 26.

Division of Endocrinology, Hospital de Clínicas, Universidad de Buenos Aires, Buenos Aires, Argentina.

Insulinomas are pancreatic neuroendocrine tumors (pNET), usually benign. Akt/p27 is an intracellular pathway overexpressed in many pNET. There are no data regarding its expression in human insulinomas. Read More

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Screening key candidate genes and pathways involved in insulinoma by microarray analysis.

Medicine (Baltimore) 2018 Jun;97(22):e10826

Department of Hepatobiliary Pancreatic Surgery, Taihe Hospital.

Insulinoma is a rare type tumor and its genetic features remain largely unknown. This study aimed to search for potential key genes and relevant enriched pathways of insulinoma.The gene expression data from GSE73338 were downloaded from Gene Expression Omnibus database. Read More

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June 2018
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Exploring the Possible Prognostic Role of B-Lymphocyte Stimulator (BLyS) in a Large Series of Patients with Neuroendocrine Tumors.

Endocr Metab Immune Disord Drug Targets 2018 May 28. Epub 2018 May 28.

Department of Medical and Biological Sciences, University of Udine, Udine. Italy.

Background And Objective: BLyS (B-Lymphocyte stimulator) is over-expressed in several tumoral settings, with direct or indirect effects on neoplastic proliferation and possibly representing a therapeutic target. In this study we explored the role of BLyS in a large population of patients with neuroendocrine tumors (NETs).

Methods: The study analyzed the stored sera of 124 consecutive unselected patients with NETs: 36 lung carcinoids (24 typical, 12 atypical), 47 gastroenteric tract and 41 pancreatic (30 non-functioning and 11 functioning: 9 insulinomas, 2 glucagonomas). Read More

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Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion.

J Vis Exp 2018 05 10(135). Epub 2018 May 10.

Department of Psychiatry, University of Pittsburgh; Department of Cell Biology, University of Pittsburgh;

The detection of insulin secretion is critical for elucidating mechanisms of regulated secretion as well as in studies of metabolism. Though numerous insulin assays have existed for decades, the recent advent of homogeneous time-resolved Förster Resonance Energy Transfer (HTRF) technology has significantly simplified these measurements. This is a rapid, cost-effective, reproducible, and robust optical assay reliant upon antibodies conjugated to bright fluorophores with long lasting emission which facilitates time-resolved Förster Resonance Energy Transfer. Read More

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Utility of contrast-enhanced computed tomography in the evaluation of canine insulinoma location.

Vet Q 2018 Jun 5:1-10. Epub 2018 Jun 5.

a Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine , Utrecht University , Utrecht , The Netherlands.

Objectives: To determine 1) the sensitivity of contrast-enhanced CT (CECT) for detection of primary canine insulinomas and metastases 2) the sensitivity of CECT to locate canine insulinomas within the pancreas and 3) the CECT attenuation pattern of canine insulinomas and post-contrast phase in which insulinomas have the best visibility.

Methods: A retrospective review was performed of the medical records of 27 canine insulinoma patients. Simultaneous occurrence of blood glucose < 3. Read More

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June 2018
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Factitious Hypoglycemia Caused by a Unique Pattern of Drug Use: A Case Report.

Int J Endocrinol Metab 2018 Jan 20;16(1):e62591. Epub 2017 Dec 20.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Factitious hypoglycemia, caused by the surreptitious use of insulin and sulfonylureas, is one of the most challenging differential diagnoses of hypoglycemia. Diagnosis is usually established via exclusion with respect to the special patterns of plasma insulin and C-peptide during hypoglycemic episodes.

Case Presentation: We report a case of recurrent hypoglycemic episodes and confusing patterns of insulin and C-peptide levels. Read More

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January 2018

Site-specific glycations of apolipoprotein A-I lead to differentiated functional effects on lipid-binding and on glucose metabolism.

Biochim Biophys Acta 2018 May 23. Epub 2018 May 23.

Department of Experimental Medical Science, Lund University, S-221 84 Lund, Sweden. Electronic address:

Prolonged hyperglycemia in poorly controlled diabetes leads to an increase in reactive glucose metabolites that covalently modify proteins by non-enzymatic glycation reactions. Apolipoprotein A-I (apoA-I) of high-density lipoprotein (HDL) is one of the proteins that becomes glycated in hyperglycemia. The impact of glycation on apoA-I protein structure and function in lipid and glucose metabolism were investigated. Read More

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May 2018
2 Reads

[Insulinoma found in patient with apparent mental disorder: a case report].

Rev Gastroenterol Peru 2018 Jan-Mar;38(1):82-84

Facultad de Medicina, Universidad Nacional de San Agustín. Arequipa, Perú; Sociedad Científica de Estudiantes de Medicina Agustinos (SOCIEMA). Arequipa, Perú.

Pancreatic Insulinoma is a neuroendocrine tumor of the beta cells of the islets of Langerhans, has an incidence of 4 cases per 1 000 000 persons. We report the case of a 36-year-old woman with altered behavior associated with melancholy. Psychiatry describes an abnormal mental examination and diagnosed double depression; however, the patient had the Whipple triad and insulin/glucose ratio higher than 0. Read More

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Contrast-enhanced harmonic endoscopic ultrasound: A better choice to guide EUS-FNI for insulinoma.

Clin Res Hepatol Gastroenterol 2018 May 15. Epub 2018 May 15.

Department of Gastroenterology, First Affiliated Hospital of Guangxi Medical University, 6, Shuangyong Road, 530021 Nanning, Guangxi Zhuang Autonomous Region, PR China. Electronic address:

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Insulinoma Masquerading as Transient Neurocognitive Impairment , , .

Am J Med 2018 May 10. Epub 2018 May 10.

University of Colorado School of Medicine, Division of General Internal Medicine, 12631 East 17(th) Avenue, Aurora, CO, USA 80045.; University of Colorado School of Medicine, Division of Endocrinology, 12631 East 17(th) Avenue, Aurora, CO, USA 80045.. Electronic address:

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Frequent falls and confusion: recurrent hypoglycemia in a patient with tuberous sclerosis complex.

Clin Case Rep 2018 May 24;6(5):904-909. Epub 2018 Mar 24.

Department of Endocrinology Hammersmith Hospital Imperial College Healthcare NHS Trust Du Cane Road London W12 0HS UK.

Recurrent hypoglycemia is common, but its presentation is often insidious resulting in delays in diagnosis and significant morbidity. We describe a case of an insulinoma presenting with falls and confusion in a patient with tuberous sclerosis, demonstrating the importance of early hypoglycemia identification and a potential shared molecular pathogenesis. Read More

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Endoscopic ultrasound-guided radiofrequency ablation for management of benign solid pancreatic tumors.

Endoscopy 2018 May 4. Epub 2018 May 4.

Division of Gastroenterology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Background:  Radiofrequency ablation (RFA) has been increasingly employed in experimental and clinical settings for the management of pancreatic lesions. This study aimed to assess the safety and efficacy of endoscopic ultrasound (EUS)-guided RFA for benign solid pancreatic tumors.

Methods:  In a single-center, prospective study, 10 patients with benign solid pancreatic tumors underwent EUS-RFA. Read More

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[Severe hypoglycaemia due to insulinoma after gastric bypass surgery].

Ugeskr Laeger 2018 Apr;180(17)

Postprandial hypoglycaemia with endogenous hyper-insulinaemia is relatively common after gastric bypass (GB) surgery. However, alternative aetiologies of hypoglycaemia should be kept in mind. We report a case of severe hypo-glycaemia in a patient who had previously undergone GB surgery for morbid obesity. Read More

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Resveratrol improves uric acid-induced pancreatic β-cells injury and dysfunction through regulation of miR-126.

Biomed Pharmacother 2018 Jun 5;102:1120-1126. Epub 2018 Apr 5.

Department of Respiratory Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266003, China. Electronic address:

Resveratrol (RSV) has been reported to exert anti-inflammatory, anti-oxidant and anti-cancer effects both in vivo and in vitro, and is widely used to treat various diseases. However, the effect of RSV on type 2 diabetes (T2D) is still unclear. The present study aimed to explore the effect of RSV on UA-induced cell injury and dysfunction in pancreatic β-cells. Read More

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[Physical minimally invasive treatment of pancreatic insulinoma].

Khirurgiia (Mosk) 2018 (4):94-97

Vishnevsky Institute of Surgery of Healthcare Ministry of the Russian Federation, Moscow, Russia.

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January 2018

Minimally Invasive Versus Open Treatment for Benign Sporadic Insulinoma Comparison of Short-Term and Long-Term Outcomes.

World J Surg 2018 Apr 24. Epub 2018 Apr 24.

Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, 35041, Baldingerstrasse, Marburg, Germany.

Background: Benign insulinoma is the most common functioning neuroendocrine tumor of the pancreas, and its incidence is estimated at 0.4%. The treatment of choice is organ-preserving resection. Read More

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The LIM homeodomain protein ISL1 mediates the function of TCF7L2 in pancreatic beta cells.

J Mol Endocrinol 2018 Jul 20;61(1):1-12. Epub 2018 Apr 20.

Division of Advanced DiagnosticsToronto General Research Institute, University Health Network, Toronto, Ontario, Canada

Pancreatic β-cell deletion or its functional knockdown suggested the essential role of this Wnt pathway effector in controlling insulin secretion, glucose homeostasis and β-cell gene expression. As the LIM homeodomain protein ISL1 is a suggested Wnt pathway downstream target, we hypothesize that it mediates metabolic functions of TCF7L2. We aimed to determine the role of ISL1 in mediating the function of TCF7L2 and the incretin hormone GLP-1 in pancreatic β-cells. Read More

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July 2018
2 Reads

Autoantibodies against islet cell antigens in children with type 1 diabetes mellitus.

Oncotarget 2018 Mar 19;9(23):16275-16283. Epub 2018 Feb 19.

Department of Pediatric Endocrinology, MacKay Children's Hospital, Taipei, Taiwan.

We investigated the prevalence of glutamic acid decarboxylase 65 autoantibody (GADA), insulinoma-associated protein 2 autoantibody (IA2A), and insulin autoantibody (IAA) in 750 children with type 1 diabetes (T1D) living in Taiwan. GADA, IA2A, and IAA were measured by radioimmunoassay. The data were assessed by test, binary logistic regression, and Spearman rank correlation. Read More

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Rare malignant insulinoma with multiple liver metastases derived from ectopic pancreas: 3-year follow-up and literature review.

Onco Targets Ther 2018 3;11:1813-1819. Epub 2018 Apr 3.

Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China.

Here, we report the diagnosis and treatment of a very rare case of malignant insulinoma derived from ectopic pancreas. A middle-aged woman presented with a 6-year history of recurrent hypoglycemia with multiple lesions in liver. Admission workup revealed elevated serum insulin and C-peptide, as well as multiple lesions in the liver (largest being 4. Read More

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April 2018
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[A case of insulinoma complicated with secondary adrenal insufficiency].

Authors:
Yao Li Hui Chen

Zhejiang Da Xue Xue Bao Yi Xue Ban 2017 May;46(6):662-665

Department of Endocrinology, the Second Hospital of Lanzhou University, Lanzhou 730030, China.

A middle-aged male patient with recurrent hypoglycemia was diagnosed as insulinoma according to the symptoms and the laboratory tests. Laboratory tests also showed low cortisol and adrenocortico-tropic hormone (ACTH) levels, therefore adrenal insufficiency was diagnosed and hydrocortisone was given. The hormone replacement therapy was terminated after surgery, and ACTH and cortisol levels returned to normal. Read More

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Hypoglycemia caused by insulinoma. A review of a case series treated at a tertiary hospital.

Rev Clin Esp 2018 Apr 12. Epub 2018 Apr 12.

Servicio de Endocrinología y Nutrición, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España.

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Modifying Enzymes are Elicited by ER Stress, Generating Epitopes that are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes.

Diabetes 2018 Apr 13. Epub 2018 Apr 13.

Benaroya Research Institute at Virginia Mason, Seattle, WA 98101 USA.

In spite of tolerance mechanisms, some individuals develop T cell mediated autoimmunity. Post-translational modifications that increase the affinity of epitope presentation and/or recognition represent one means through which self-tolerance mechanisms can be circumvented. We investigated T cell recognition of peptides that correspond to modified beta cell antigens in subjects with type 1 diabetes. Read More

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April 2018
8 Reads

[Surgical strategies for small sporadic neuroendocrine pancreatic tumors].

Authors:
K Holzer

Chirurg 2018 Jun;89(6):422-427

Sektionsleitung Endokrine Chirurgie, Klinik für Viszeral‑, Thorax- und Gefäßchirurgie, Universitätsklinikum Marburg, Baldingerstraße, 35043, Marburg, Deutschland.

Small (<2 cm) sporadic neuroendocrine pancreatic neoplasms (pNENs) are a heterogeneous group of neoplasms, which can be separated into functionally active or non-functional tumors. Functionally active pNENs release various hormones, such as insulin, gastrin, glucagon and vasoactive intestinal hormones and therefore lead to severe symptoms independent of their size. The main symptoms include hypoglycemia, coma (insulinoma), diarrhea (gastrinoma, VIPoma), intestinal ulcers (gastrinoma) and hyperglycemia (glucagonoma). Read More

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Diagnostic challenges in a patient with an occult insulinoma:Ga-DOTA-exendin-4 PET/CT and Ga-DOTATATE PET/CT.

Clin Case Rep 2018 Apr 1;6(4):719-722. Epub 2018 Mar 1.

Department of Endocrinology & DiabetesSt Vincent's HospitalMelbourneVictoriaAustralia.

Despite growing evidence for GLP-1R molecular-based imaging, successful localization of insulinomas may require the use of multiple imaging modalities. Not all benign insulinomas express the GLP-1R as expected. Our case demonstrates that there is a still an important role for traditional methods for the anatomical localization of an insulinoma. Read More

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Management of functional neuroendocrine tumors of the pancreas.

Authors:
Kjell Öberg

Gland Surg 2018 Feb;7(1):20-27

Department of Medical Sciences, Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden.

Pancreatic neuroendocrine tumors (pNETs) constitute a heterogenous group of malignancies with varying clinical presentation, tumor biology and prognosis. The incidence of pNETs has steadily increased during the last decades with an estimated incidence 2012 of 4.8/100,000. Read More

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February 2018
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Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells.

Biochim Biophys Acta 2018 Apr 6. Epub 2018 Apr 6.

Department of Biological Sciences, The George Washington University, Washington, DC 20052, USA. Electronic address:

Misfolded toxic human islet amyloid polypeptide or amylin (hA) and plasma membrane-associated redox complex, NADPH oxidase (NOX), have been implicated in the islet β-cell demise associated with type-2 diabetes mellitus (T2DM). Studies show that hA accumulation is stressful to β-cells and that misfolding of human amylin evokes redox stress and activates mitogen activated protein (MAP) kinases, p38 MAPK and c-Jun N-terminal (JNK) kinase. However, the molecular link and causality between hA-evoked redox stress, NOX activity and MAP kinases signaling in pancreatic β-cells is incompletely understood. Read More

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April 2018
2 Reads

Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice.

J Endocr Soc 2018 Mar 30;2(3):207-219. Epub 2018 Jan 30.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.

The proliferation of pancreatic cells is enhanced to enable an increase in -cell mass and to compensate for insulin resistance during pregnancy. To elucidate the mechanisms involved, we previously investigated islets from pregnant and nonpregnant mice by gene expression profiling and found that the expression of postsynaptic density-95/Discs large/zonula occludens-1 (PDZ)-binding kinase (Pbk), a member of the mitogen-activated protein kinase kinase family, is increased in pregnant mouse islets compared with control mouse islets. Among the pregnancy hormones, treatment with estradiol upregulated expression. Read More

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March 2018
2 Reads

[Multidisciplinary approach to surgical disorders of the pancreas in children].

Rozhl Chir 2018 ;97(3):109-116

Introduction: Surgical diseases of the pancreas in children are not common and may be associated with significant morbidity and potential mortality. A multidisciplinary approach is essential for correct diagnosis, surgical strategy and postoperative as well as follow-up care.

Method: Retrospective analysis of patients operated on due to a pathological lesion of the pancreas focused on diagnostics, operating procedures, postoperative complications, and long-term results. Read More

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January 2018
2 Reads

Pioglitazone Attenuates Palmitate-Induced Inflammation and Endoplasmic Reticulum Stress in Pancreatic β-Cells.

Endocrinol Metab (Seoul) 2018 Mar;33(1):105-113

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: The nuclear receptor peroxisome proliferator-activator gamma (PPARγ) is a useful therapeutic target for obesity and diabetes, but its role in protecting β-cell function and viability is unclear.

Methods: To identify the potential functions of PPARγ in β-cells, we treated mouse insulinoma 6 (MIN6) cells with the PPARγ agonist pioglitazone in conditions of lipotoxicity, endoplasmic reticulum (ER) stress, and inflammation.

Results: Palmitate-treated cells incubated with pioglitazone exhibited significant improvements in glucose-stimulated insulin secretion and the repression of apoptosis, as shown by decreased caspase-3 cleavage and poly (adenosine diphosphate [ADP]-ribose) polymerase activity. Read More

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March 2018
12 Reads

Insulin Autoimmune Syndrome: a rare case of hypoglycaemia resolving with immunosuppression.

Ulster Med J 2018 Jan 31;87(1):34-36. Epub 2018 Jan 31.

Endocrinology and Diabetes, Mater Hospital, 47-51 Crumlin Rd, Belfast, BT14 6AB.

We report a case of a 58-year-old male presenting with confusion and hypoglycaemia. There had been no prior exposure to oral hypoglycaemic agents or insulin. He was found to have inappropriate endogenous hyperinsulinaemia. Read More

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January 2018
1 Read

Scopoletin intervention in pancreatic endoplasmic reticulum stress induced by lipotoxicity.

Cell Stress Chaperones 2018 Mar 25. Epub 2018 Mar 25.

Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Tamil Nadu, 608002, India.

Endoplasmic reticulum (ER), a dynamic organelle, plays an essential role in organizing the signaling pathways involved in cellular adaptation, resilience, and survival. Impairment in the functions of ER occurs in a variety of nutritive disorders including obesity and type 2 diabetes. Here, we hypothesize that (scopoletin) SPL, a coumarin, has the potential to alleviate ER stress induced in vitro and in vivo models by lipotoxicity. Read More

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Puerarin promotes MIN6 cell survival by reducing cellular reactive oxygen species.

Mol Med Rep 2018 May 14;17(5):7281-7286. Epub 2018 Mar 14.

Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China.

Type 1 diabetes is caused by destruction of the pancreatic β‑cells and, to date, no cure has been developed. Promoting the survival of pancreatic β‑cells may be beneficial for patients with type 1 diabetes. Puerarin is an estrogen analogue that been demonstrated in previous studies to be able to decreased blood glucose in patients with type 1 diabetes. Read More

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May 2018
1 Read

Overexpression of appoptosin promotes mitochondrial damage in MIN6 cells.

Mol Med Rep 2018 May 16;17(5):7149-7155. Epub 2018 Mar 16.

Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China.

Damage to pancreatic β‑cells is closely associated with diabetes. However, the mechanism underlying injury to pancreatic β‑cells remains unclear, although hypoxia is considered as one of the leading causes. Appoptosin is a mitochondrial protein that promotes neuronal apoptosis. Read More

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May 2018
1 Read

Hyperinsulinemic hypoglycemia without insulinoma: Think of activating glucokinase mutation.

Presse Med 2018 Jun 17;47(6):595-597. Epub 2018 Mar 17.

Lille University Hospital, C. Huriez Hospital, Endocrinology and Metabolism Department, 1, rue Polonovski, 59037 Lille cedex, France; INSERM U1190 Translational Research in Diabetes, 59037 Lille, France; E.G.I.D - FR3508 European Genomic Institute for Diabetes, 59037 Lille, France. Electronic address:

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June 2018
1 Read

Endothelial and beta cell composite aggregates for improved function of a bioartificial pancreas encapsulation device.

Int J Artif Organs 2018 Mar 20;41(3):152-159. Epub 2018 Feb 20.

1 Bioartificial Organs, Biomaterials Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands.

Introduction: Encapsulation of pancreatic islets or beta cells is a promising strategy for treatment of type 1 diabetes by providing an immune isolated environment and allowing for transplantation in a different location than the liver. However, islets used for encapsulation often show lower functionality due to the damaging of islet endothelial cells during the isolation procedure. Factors produced by endothelial cells have great impact on beta cell insulin secretion. Read More

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March 2018
2 Reads

Pseudo-hemorrhagic region formation in pancreatic neuroendocrine tumors is a result of blood vessel dilation followed by endothelial cell detachment.

Oncol Lett 2018 Apr 22;15(4):4255-4261. Epub 2018 Jan 22.

Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Chaoyang, Beijing 100029, P.R. China.

Aberrant blood vessel formation and hemorrhage may contribute to tumor progression and are potential targets in the treatment of several types of cancer. Pancreatic neuroendocrine tumors (PNETs) are highly vascularized, particularly when they are well-differentiated. However, the process of vascularization and endothelial cell detachment in PNETs is poorly understood. Read More

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Improved Labeling of Pancreatic Islets Using Cationic Magnetoliposomes.

J Pers Med 2018 Mar 12;8(1). Epub 2018 Mar 12.

Biomedical MRI/MoSAIC, Department of Imaging and Pathology, University of Leuven, Herestraat 49, B3000 Leuven, Belgium.

Pancreatic islets (PIs) transplantation is an alternative approach for the treatment of severe forms of type 1 diabetes (T1D). To monitor the success of transplantation, it is desirable to follow the location of engrafted PIs non-invasively. In vivo magnetic resonance imaging (MRI) of transplanted PIs is a feasible cell tracking method; however, this requires labeling with a suitable contrast agent prior to transplantation. Read More

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March 2018
2 Reads

Usefulness of four-dimensional flow-sensitive magnetic resonance imaging to evaluate hemodynamics in the pancreaticoduodenal artery.

Clin J Gastroenterol 2018 Mar 5. Epub 2018 Mar 5.

Second Department of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.

Pancreaticoduodenal artery (PDA) aneurysm associated with celiac axis compression by the median arcuate ligament (MAL) is a rare disorder, but may be lethal if ruptured. Therefore, prophylactic surgical treatments need to be considered when MAL compresses the celiac axis. We herein report the usefulness of an arterial flow analysis for objectively evaluating this pathophysiology under four-dimensional flow-sensitive magnetic resonance imaging (4D-flow MRI). Read More

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IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells.

J Cell Biol 2018 Apr 5;217(4):1287-1301. Epub 2018 Mar 5.

Graduate School of Biological Sciences and Institute for Research Initiatives, Nara Institute of Science and Technology, Ikoma, Japan

In mammalian pancreatic β cells, the IRE1α-XBP1 pathway is constitutively and highly activated under physiological conditions. To elucidate the precise role of this pathway, we constructed β cell-specific conditional knockout (CKO) mice and established insulinoma cell lines in which was deleted using the Cre-loxP system. CKO mice showed the typical diabetic phenotype including impaired glycemic control and defects in insulin biosynthesis postnatally at 4-20 weeks. Read More

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Radiosynthesis and evaluation of an F-labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma.

EJNMMI Radiopharm Chem 2018 2;3(1). Epub 2018 Jan 2.

2Center for Radiopharmaceutical Sciences (CRS), Research Department Biology and Chemistry, Paul Scherrer Institut, CH-5232 Villigen, Switzerland.

Background: Analogues of exendin-4 have been radiolabeled for imaging the glucagon-like peptide type 1 receptors (GLP-1R) which are overexpressed in insulinoma. The aim of this research was to synthesize an F-labeled silicon containing exendin-4 peptide (F-) and to evaluate its in vitro and behavior in CHL-GLP-1 receptor positive tumor-bearing mice. F-labeled silicon containing exendin-4 peptide (F-) was prepared via one-step nucleophilic substitution of a silane precursor with F-fluoride in the presence of acetic acid and K222. Read More

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January 2018