Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival.
- Heather L Hayes,
- Brett S Peterson,
- Jonathan M Haldeman,
- Christopher B Newgard,
- Hans E Hohmeier,
- Samuel B Stephens
PLoS One 2017 17;12(2):e0172567. Epub 2017 Feb 17.
Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.
Increased β-cell death coupled with the inability to replicate existing β-cells drives the decline in β-cell mass observed in the progression of both major forms of diabetes. Understanding endogenous mechanisms of islet cell survival could have considerable value for the development of novel strategies to limit β-cell loss and thereby promote β-cell recovery. Insulinoma cells have provided useful insight into β-cell death pathways but observations made in cell lines sometimes fail to translate to primary islets. Read More