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J Chromatogr B Analyt Technol Biomed Life Sci 2022 Jun 10;1205:123335. Epub 2022 Jun 10.

Institut de médecine légale, 11 rue Humann, 67000 Strasbourg, France; X-Pertise Consulting, 42 rue principale, 67206, Mittelhausbergen, France.

Oral antidiabetics are the drugs used to control blood sugar in diabetic subjects. The greatest risk of using these drugs is hypoglycaemia, which can be fatal if managed inappropriately. The diagnosis of hypoglycemia may be simple in diabetic subjects but can become a challenge in subjects with no history of exposure to these drugs. Read More

Niger J Clin Pract 2022 Jun;25(6):971-973

Department for HBP Surgery, Clinic for Digestive Surgery, University Clinical Centre of Serbia, Dr Koste Todorovica; Department for Surgery with Anesthesiology, Faculty of Medicine, University of Belgrade, Dr Subotica, Belgrade, Serbia.

Insulinoma is the most common functional solitary, benign pancreatic neuroendocrine tumor. In this paper, we share our experience of triple pancreatic insulinomas, with an idea to highlight the fact that despite the high frequency of solitary insulinoma, there is the possibility of multiple lesions and point out the need for a systematic and detailed radiographic and clinical examination. A 33-year-old woman was admitted to our clinic due to chronic fatigue, sweating, sporadic episodes of palpitations, unsteady hands, and blurred images, which resolve spontaneously after a few minutes. Read More

Obes Surg 2022 Jun 15. Epub 2022 Jun 15.

Min-Sheng General Hospital, Taoyuan City, Taiwan.

Purpose: One anastomosis/mini gastric bypass (OAGB/MGB) is up to date the third most performed obesity and metabolic procedure worldwide, which recently has been endorsed by ASMBS. The main criticisms are the risk of bile reflux, esophageal cancer, and malnutrition. Although IFSO has recognized this procedure, guidance is needed regarding selection criteria. Read More

Chemistry 2022 Jun 14:e202201698. Epub 2022 Jun 14.

Department of Chemistry, New York University, New York, NY, 10003, USA.

Invited for the cover of this issue is the group of Prof. Hamilton at New York University. The image depicts cucurbit[7]uril inhibits islet amyloid polypeptide self-assembly that rescues rat insulinoma cells (a pancreatic β-cell model) from assembly-associated cytotoxicity. Read More

BMJ Case Rep 2022 Jun 14;15(6). Epub 2022 Jun 14.

Internal Medicine, Army Hospital Research and Referral, New Delhi, India

A female patient in her early sixties had problems of recurrent syncopal attacks and panic attacks over the last 5 years. She had been initially managed for an anxiety disorder with psychiatric medications. During one of those episodes, she was brought to our hospital in an unconscious state with a low blood sugar level of 43 mg/dL. Read More

J Clin Invest 2022 Jun 14. Epub 2022 Jun 14.

Director, Diabetes, Obesity and Metabolism Institute, Mount Sinai School of Medicine, New York, United States of America.

Resistance to regeneration of insulin-producing pancreatic beta cells is a fundamental challenge for Type 1 and Type 2 diabetes. Recently, small molecule inhibitors of the kinase DYRK1A have proven effective in inducing adult human beta cells to proliferate, but their detailed mechanism of action is incompletely understood. We interrogated our human insulinoma and beta cell transcriptomic databases seeking to understand why beta cells in insulinomas proliferate, while normal beta cells do not. Read More

Orphanet J Rare Dis 2022 06 13;17(1):219. Epub 2022 Jun 13.

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Objective: To investigate the clinical characteristics of patients with multiple endocrine neoplasia type 1 (MEN1)-related insulinoma and their relationship with specific biochemical changes and to summarize the features of treatment options for the Chinese population with this disease and the impact on long-term prognosis.

Methods: "MEN1" and "insulinoma" were used when searching the Peking Union Medical College Hospital (PUMCH) medical record retrieval system to obtain clinical information about patients. We identified patients diagnosed with MEN1-associated insulinoma based on endocrinological, radiological, and pathological examinations, and subsequently analyzed their clinical data. Read More

Front Endocrinol (Lausanne) 2022 24;13:906012. Epub 2022 May 24.

Endocrinology Department, St George Public Hospital, Sydney, NSW, Australia.

We describe a 96-year-old man with insulin-dependent type 2 diabetes mellitus who, despite insulin cessation, presented with recurrent hypoglycemia associated with confirmed inappropriate endogenous hyperinsulinemia. Ga-DOTATATE-PET/CT scans demonstrated increased uptake in the pancreatic tail with multiple large intensely active liver metastases. Liver biopsy confirmed the diagnosis of well-differentiated metastatic neuroendocrine tumor. Read More

J Immunol Res 2022 25;2022:3532685. Epub 2022 May 25.

Department of Clinical Sciences, Lund University/Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.

Objective: The objective of this study was to explore whether recombinant GAD65 conjugated hydroxide (GAD-alum) treatment affected peripheral blood T-cell subpopulations in healthy children with multiple beta cell autoantibodies.

Method: The Diabetes Prevention-Immune Tolerance 2 (DiAPREV-IT 2) clinical trial enrolled 26 children between 4 and 13 years of age, positive for glutamic acid decarboxylase autoantibody (GADA) and at least one other autoantibody (insulin, insulinoma antigen-2, or zinc transporter 8 autoantibody (IAA, IA-2A, or ZnT8A)) at baseline. The children were randomized to two doses of subcutaneously administered GAD-alum treatment or placebo, 30 days apart. Read More

Int J Surg Case Rep 2022 May 21;94:107115. Epub 2022 Apr 21.

Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8606, Japan.

Introduction And Importance: Most insulinomas are benign and solitary, with a tumor diameter less than 2 cm; therefore, laparoscopic enucleation, which is a minimally invasive procedure that can preserve the pancreatic parenchyma, is considered an optimal procedure. The key to enucleation is to avoid injury to the main pancreatic duct (MPD). Herein, we present a case in which single-incision laparoscopic enucleation (SILE) was performed for insulinomas, with preoperative nasopancreatic stent (NPS) placement. Read More

Endocr J 2022 May 27. Epub 2022 May 27.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

VIPomas are generally rare functioning pancreatic neuroendocrine tumors (PanNETs) that cause watery diarrhea, hypokalemia, and achlorhydria. Due to their extreme rarity, the clinicopathological features and outcomes of VIPomas have not been well reported. This study aimed to determine the diagnostic and therapeutic characteristics and prognosis of VIPomas and to compare them with other PanNETs at a Japanese reference hospital. Read More

Endocrinol Diabetes Metab Case Rep 2022 Jun 1;2022. Epub 2022 Jun 1.

Department of Internal Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Summary: Acanthosis nigricans (AN) is a common dermatosis associated with hyperinsulinemia and insulin resistance. However, AN has been rarely reported in patients with insulinoma, a state of persistent hyperinsulinemia. We present a case of metastatic insulinoma, in whom AN manifested after the first cycle of peptide receptor radionuclide therapy (PRRT). Read More

Endocrinol Diabetes Metab Case Rep 2022 Jun 1;2022. Epub 2022 Jun 1.

Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Summary: Sulphonylureas are insulinotropic and are not only useful in patients with diabetes but also act in non-diabetic individuals where hypoglycaemia and hyperinsulinism mimic insulinoma. We present a 63-year-old man who presented with inadvertent sulphonylurea-induced life-threatening hypoglycaemia on two occasions, resulting in hazardous and invasive investigation. Biochemistry revealed endogenous hyperinsulinaemia, with elevated serum c-peptide and insulin concentrations during symptomatic hypoglycaemia, and plasma glucose of 1. Read More

Biofabrication 2022 05 26;14(3). Epub 2022 May 26.

Jiangxi Provincal Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering, Gannan Medical University, Ganzhou, People's Republic of China.

Coaxial bioprinting of hydrogel tubes has tremendous potential in the fabrication of highly complex large-scale vascularized structures, however, constructs with bioinks of simultaneous weak printability and perfusable networks have not been reported. Here, we report a coaxial printing method in which double-channel filaments are three-dimensional (3D) extrusion-bioprinted using a customized dual-core coaxial nozzle. The filament in one channel can perform core/shell role and the other channel can play a role in perfusion. Read More

AACE Clin Case Rep 2022 May-Jun;8(3):139-141. Epub 2022 Jan 3.

Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Francisco, California.

Background: Oral hypoglycemic agents are a frequent cause of hypoglycemia in nondiabetic people. Here, we report a case of recurrent hypoglycemia caused by glipizide, in which diagnosis was delayed because of a combination of delayed hypoglycemic agent screening and low sensitivity of the hypoglycemic agent screening panel used.

Case Report: A 66-year-old woman repeatedly presented with symptomatic hypoglycemia. Read More

Dis Markers 2022 11;2022:1868749. Epub 2022 May 11.

Department of Endocrinology, Zhuji People's Hospital of Zhejiang Province, Zhejiang 311800, China.

This study is aimed at investigating the treatment effectiveness of HIV-1 protease inhibitor for rats with insulinoma and its effects on interleukin-1 (IL-1) and interleukin-18 (IL-18). A total of 40 6-week-old nude mice were included in this study. We randomly assigned 20 rats for insulinoma modeling and divided them into model A and B groups. Read More

CMAJ 2022 May;194(19):E684-E688

Division d'endocrinologie et de métabolisme (Vu, Mereu, Ghosh) et Division de médecine interne (Wang), Département de médecine, Université de l'Alberta, Edmonton, Alb.

Front Cell Dev Biol 2022 28;10:894422. Epub 2022 Apr 28.

Children's Health Research Institute, London, ON, Canada.

β1-integrin is a key receptor that regulates cell-ECM interactions and is important in maintaining mature beta-cell functions, including insulin secretion. However, there is little reported about the relationship between ECM-β1-integrin interactions and exocytotic proteins involved in glucose-stimulated insulin secretion (GSIS). This study examined the effect of collagen IV-β1-integrin on exocytotic proteins (Munc18-1, Snap25, and Vamp2) involved in insulin secretion using rat insulinoma (INS-1) cell line. Read More

Commun Biol 2022 05 13;5(1):458. Epub 2022 May 13.

Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, 371-8512, Japan.

Insulin is an essential peptide hormone that maintains blood glucose levels. Although the mechanisms underlying insulin exocytosis have been investigated, the mechanism of proinsulin export from the endoplasmic reticulum (ER) remains unclear. Here, we demonstrated that Surf4, a cargo receptor homolog, regulates the ER export of proinsulin via its recruitment to ER exit sites (ERES). Read More

Sci Rep 2022 May 11;12(1):7713. Epub 2022 May 11.

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.

The role of ER Ca release via ryanodine receptors (RyR) in pancreatic β-cell function is not well defined. Deletion of RyR2 from the rat insulinoma INS-1 (RyR2) enhanced IP receptor activity stimulated by 7.5 mM glucose, coincident with reduced levels of the protein IP Receptor Binding protein released with Inositol 1,4,5 Trisphosphate (IRBIT). Read More

Acta Biochim Biophys Sin (Shanghai) 2022 Mar;54(3):370-377

Department of Biochemistry and Molecular Biology, Hengyang Medical School, University of South China, Hengyang 421001, China.

Oxidative stress and endoplasmic reticulum (ER) stress play crucial roles in pancreatic β cell destruction, leading to the development and progression of type 1 diabetes mellitus (T1DM). Curcumin, extracted from plant turmeric, possesses multiple bioactivities such as antioxidant, anti-inflammatory and anti-apoptosis properties and . However, it remains unknown whether curcumin improves ER stress to prevent β cells from apoptosis. Read More

Anal Biochem 2022 Jul 7;649:114722. Epub 2022 May 7.

Medical laboratory of Shenzhen Luohu Hospital Group, 518003, China. Electronic address:

Autoantibodies are currently the most robust biomarkers of type 1 diabetes. However, single autoantibody targeted detection is still limited in diabetes diagnosis with poor performance. Here, we develop a multiplexed Array-ELISA assay that can detect five diabetes-related autoantibodies including glutamic acid decarboxylase antibody (GADA), insulinoma antigen 2 antibody (IA-2A), islet cell antibody (ICA), zinc transporter 8 autoantibody (ZnT8-A) and insulin antibody (IAA) simultaneously. Read More

Chemistry 2022 May 9:e202200456. Epub 2022 May 9.

Department of Chemistry, New York University, New York, NY 10003, USA.

Two "hot segments" within an islet amyloid polypeptide are responsible for its self-assembly, which in turn is linked to the decline of β-cells in type 2 diabetes (T2D). A readily available water-soluble, macrocyclic host, cucurbit[7]uril (CB[7]), effectively inhibits islet amyloid polypeptide (IAPP) aggregation through ion-dipole and hydrophobic interactions with different residues of the monomeric peptide in its random-coil conformation. A HSQC NMR study shows that CB[7] likely modulates IAPP self-assembly by interacting with and masking major residues present in the "hot segments" at the N terminus. Read More

Case Rep Gastroenterol 2022 Jan-Apr;16(1):159-164. Epub 2022 Mar 28.

Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.

Gastric plexiform fibromyxoma is extremely rare. In our case, upper gastrointestinal endoscopy of a 41-year-old woman patient revealed a 1-cm submucosal tumor (SMT) in the greater curvature of the lower body of the stomach. On contrast-enhanced computed tomography, the tumor was hypervascular in the arterial phase with continuous enhancement in the post-venous phase. Read More

Front Bioeng Biotechnol 2022 19;10:884071. Epub 2022 Apr 19.

Department of Chemical Engineering, McGill University, Montréal, QC, Canada.

Islet encapsulation devices serve to deliver pancreatic beta cells to type 1 diabetic patients without the need for chronic immunosuppression. However, clinical translation is hampered by mass transport limitations causing graft hypoxia. This is exacerbated in devices relying only on passive diffusion for oxygenation. Read More

Front Endocrinol (Lausanne) 2022 19;13:860614. Epub 2022 Apr 19.

Department of Medical Oncology, Institut Paoli-Calmettes, European Neuroendocrine Tumor Society (ENETS) Center of Excellence, Institut Paoli-Calmettes Neuroendocrine Tumor (IPC NET) Center, Marseille, France.

Malignant insulinomas are functional neuroendocrine tumors of the pancreas and the primary cause of tumor-related hypoglycemia. Malignant insulinoma is rare and has a poor prognosis. We report a case of metastatic malignant insulinoma in a 64-year-old female patient with severe and refractory hypoglycemia. Read More

Endocrinol Diabetes Metab Case Rep 2022 May 1;2022. Epub 2022 May 1.

Sri Jayawardenepura General Hospital, Nugegoda, Sri Lanka.

Summary: Treatment of insulinoma can be challenging, while surgical resection is considered the first line. When surgery is contraindicated or is refused, minimally invasive procedures such as selective arterial embolization, local ablative techniques including alcohol ablation, radiofrequency ablation and microwave ablation are being used of late. The world's first microwave ablation of insulinoma was performed in 2015, after which there have been only a handful of reported cases. Read More

Exp Clin Endocrinol Diabetes 2022 Jun 24. Epub 2022 Jun 24.

Center for Endocrinology, Diabetology & Osteology of Philipps-University Marburg 35037 Marburg, Germany.

Objective: Insulinoma is a rare tumor of the pancreas that can lead to spontaneous hypoglycemia due to excessive insulin secretion. Seventy-two-hour fast is the gold standard for finding the correct diagnosis. Endoscopic ultrasound is an established examination method to identify the suspicious lesion. Read More

Neuro Endocrinol Lett 2021 Dec 21;42(8):522-527. Epub 2021 Dec 21.

Clinic of internal medicine - gastroenterology, JFM CU, Jessenius Faculty of Medicine in Martin (JFM CU), Comenius University in Bratislava, Slovakia.

Introduction: Insulinomas are rare neuroendocrine tumors of pancreas. Clinical manifestations include various symptoms of hypoglycemia, which is the result of insulin overproduction. Symptoms of hypoglycemia are heterogenous what most probably contributes to diagnostic delay. Read More

Korean J Physiol Pharmacol 2022 May;26(3):165-174

Department of Pediatrics, Shanxi Medical University, Taiyuan 030001, China.

As the mechanism underlying glucose metabolism regulation by oxymatrine is unclear, this study investigated the effects of oxymatrine on pyroptosis in INS-1 cells. Flow cytometry was employed to examine cell pyroptosis and reactive oxygen species (ROS) production. Cell pyroptosis was also investigated via transmission electron microscopy and lactate dehydrogenase (LDH) release. Read More