114,990 results match your criteria Insulin Resistance


Picomolar detection of retinol binding protein 4 for early management of type II diabetes.

Biosens Bioelectron 2018 Dec 24;128:122-128. Epub 2018 Dec 24.

CNR NANOTEC Institute of Nanotechnology, via Monteroni, 73100 Lecce, Italy; Department of Mathematics and Physics, University of Salento, via Monteroni, 73100 Lecce, Italy. Electronic address:

Type (II) diabetes is one of the major threats to mankind as it causes insulin resistance in human body and Retinol Binding Protein 4 (RBP4) is currently considered as a potential biomarker for early management of this disease. Hence a low-level detection of RBP4 is a very important task and for this purpose, a novel RBP4 biosensor has been developed using homemade plastic chip electrodes (PCEs) as a platform for self-assembled monolayer (SAM) of 4-ATP and further functionalization with glutaraldehyde. Anti RBP4 is used as biorecognition species and electrochemical impedance spectroscopy has been performed to detect different RBP4 concentrations plotted against charge transfer resistance. Read More

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http://dx.doi.org/10.1016/j.bios.2018.12.032DOI Listing
December 2018

Utility of combined inflammatory biomarkers for the identification of cognitive dysfunction in non-diabetic participants of the ELSA-Brasil.

Psychoneuroendocrinology 2019 Jan 9;103:61-66. Epub 2019 Jan 9.

Department of Epidemiology, School of Public Health, University of Sao Paulo, Brazil. Electronic address:

Introduction: Insulin resistance and low-grade inflammation are pathophysiological mechanisms shared by type 2 diabetes and dementia. A cluster of biomarkers that could help diagnosing cognitive dysfunction prior to the installation of insulin resistance is desirable. This ELSA sub-study examined whether a cluster of selected inflammatory biomarkers was associated with worse cognitive scores in non-diabetic participants. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.01.003DOI Listing
January 2019

Formononetin attenuates kidney damage in type 2 diabetic rats.

Life Sci 2019 Jan 11. Epub 2019 Jan 11.

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, V.L.Mehta road, Vile Parle (W), Mumbai 400056, India. Electronic address:

Aim: Diabetic nephropathy is the commonly developed complication of vasculature in type 2 diabetic patients. Chronic hyperglycemia leads to nephropathy in diabetics because of the formation of excessive reactive oxygen species and advanced glycation end products which is reflected in the form of glomerulosclerosis, tubular atrophy and interstitial fibrosis. As per the various reports reduction in SIRT1 expression in kidney tissue is key factor in the development of nephropathy in diabetes because its reduction in tissue is linked with excessive formation of ROS. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.013DOI Listing
January 2019

[Barriers of the initiation of insulin treatment in type 2 diabetic patients - conquering the "psychological insulin resistance"].

Orv Hetil 2019 Jan;160(3):93-97

Kórélettani Intézet, Safárik Egyetem, Orvosi Kar SK 04001 Košice, 1 SNP Avenue, Slovakia.

Type 2 diabetes is a progressive disease and its consequence is the gradual decrease of endogenous insulin secretion to a very low level. Beyond this point, without insulin it is not possible to achieve proper metabolic compensation. The authors are trying to explain why the insulin therapy is often delayed in type 2 diabetic patients despite existing guidelines about its initiation and continuation. Read More

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http://dx.doi.org/10.1556/650.2019.31269DOI Listing
January 2019

[Relation between sexual dysfunction and metabolic syndrome].

Orv Hetil 2019 Jan;160(3):98-103

Egészségfejlesztési és Népegészségtani Tanszék, Pécsi Tudományegyetem, Egészségtudományi Kar Pécs.

The prevalence of the metabolic syndrome, type 2 diabetes mellitus, cardiovascular diseases, obesity and depression have increased during the recent years. As the sexual dysfunction is also frequent, we aimed to search for the associations between sexual dysfunction and the metabolic syndrome and its components, respectively, by reviewing the literature. The clinical and biochemical components of the metabolic syndrome included cardiovascular disease, type 2 diabetes mellitus, visceral obesity and depression, furthermore, insulin resistance, atherogenic lipid profile, hypogonadism, chronic systemic inflammation and endothelial dysfunction were all demonstrated to affect adversely the sexual function. Read More

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http://dx.doi.org/10.1556/650.2019.31235DOI Listing
January 2019

Are plasma 25-hydroxyvitamin D and retinol levels and one-carbon metabolism related to metabolic syndrome in patients with a severe mental disorder?

Psychiatry Res 2019 Jan 3;273:22-29. Epub 2019 Jan 3.

Department of Psychiatry, University of Oviedo, Oviedo, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.

There is a scarcity of studies assessing the influence of biomarkers in metabolic syndrome in psychiatric patients. Our aim was to correlate serum or plasma levels of 25-hydroxyvitamin D (25-OH-VD), retinol, vitamin B12 (VB12), folate and homocysteine (Hcy), with the metabolic status, in a sample of 289 outpatients with Schizophrenia or Bipolar Disorder. Logistic regression and multiple linear regressions were performed to assess the ability of biomarkers to predict the presence of MetS, the number of risk factors for MetS, and insulin resistance indexes (HOMA and QUICKI). Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.005DOI Listing
January 2019

Transition from metabolically benign to metabolically unhealthy obesity and 10-year cardiovascular disease incidence: the ATTICA cohort study.

Metabolism 2019 Jan 10. Epub 2019 Jan 10.

First Cardiology Clinic, School of Medicine, University of Athens, Greece.

Background/objectives: Metabolically benign obesity remains a scientific field of considerable debate.The aim of the present work was to evaluate whether metabolically healthy obese (MHO) status is a transient condition which propagates 10-year cardiovascular disease (CVD) onset.

Methods: A prospective longitudinal study was conducted during 2001-2012, the ATTICA study studying 1514 (49. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.003DOI Listing
January 2019

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits.

Cell Metab 2019 Jan 8. Epub 2019 Jan 8.

Department of Medicine/Division of Cardiology and Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:

We studied sex differences in over 50 cardio-metabolic traits in a panel of 100 diverse inbred strains of mice. The results clearly showed that the effects of sex on both clinical phenotypes and gene expression depend on the genetic background. In support of this, genetic loci associated with the traits frequently showed sex specificity. Read More

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http://dx.doi.org/10.1016/j.cmet.2018.12.013DOI Listing
January 2019

Childhood trauma and insulin resistance in patients suffering from depressive disorders.

Exp Neurol 2019 Jan 10. Epub 2019 Jan 10.

Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, USA; Center for Neuroscience in Women's Health, Stanford University, Palo Alto, CA 91304, USA. Electronic address:

Objective: Insulin resistance (IR) is a metabolic dysfunction often co-morbid with major depressive disorder (MDD). The paths to development of MDD remain largely unspecified, highlighting a need for identification of risk factors. Here, we tested whether specific subscales of childhood trauma as well as family history of type-2 diabetes (Fam-Hx-Dm2) contribute to the development of metabolic dysfunction and severity of depressive symptoms. Read More

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http://dx.doi.org/10.1016/j.expneurol.2019.01.005DOI Listing
January 2019

Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response.

Cell Stem Cell 2018 Dec 23. Epub 2018 Dec 23.

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

Thiazolidinedione drugs (TZDs) target the transcriptional activity of peroxisome proliferator activated receptor γ (PPARγ) to reverse insulin resistance in type 2 diabetes, but side effects limit their clinical use. Here, using human adipose stem cell-derived adipocytes, we demonstrate that SNPs were enriched at sites of patient-specific PPARγ binding, which correlated with the individual-specific effects of the TZD rosiglitazone (rosi) on gene expression. Rosi induction of ABCA1, which regulates cholesterol metabolism, was dependent upon SNP rs4743771, which modulated PPARγ binding by influencing the genomic occupancy of its cooperating factor, NFIA. Read More

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http://dx.doi.org/10.1016/j.stem.2018.11.018DOI Listing
December 2018

Microembolic Signals is Associated With Insulin Resistance Among Acute Ischemic Stroke Patients.

J Stroke Cerebrovasc Dis 2019 Jan 9. Epub 2019 Jan 9.

Department of neurology, the Second Affiliated Hospital of Nantong University, Nantong, China. Electronic address:

Background: Microembolic signals (MES) and insulin resistance (IR) is common in patients with acute ischemic stroke (AIS). Patients with active MES tend to be more seriously ill and prone to aggravating disease progression. IR is an important risk factor for stroke which has been found to be associated with the severity of stroke. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.033DOI Listing
January 2019

Essential amino acid-enriched meal replacement promotes superior net protein balance in older, overweight adults.

Clin Nutr 2018 Dec 19. Epub 2018 Dec 19.

Essential Blends, LLC, Fairbanks, AK, USA; Department of Geriatrics, Center for Translational Research in Aging & Longevity, Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Background & Aims: Older individuals are susceptible to the loss of muscle and accumulation of fat. To address this problem, we have compared protein kinetics following consumption of an essential amino acid (EAA)-enriched meal replacement (EMR) to consumption of a high-protein meal replacement beverage (Bariatric Advantage, BA) using stable isotope methodology.

Methods: Eight older (67 ± 2), obese (35 ± 2 kg/m) female and male participants completed two studies using a randomized, crossover design in which they ingested each meal replacement. Read More

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http://dx.doi.org/10.1016/j.clnu.2018.12.013DOI Listing
December 2018

Twincretin as a potential therapeutic for the management of type 2 diabetes with obesity.

J Diabetes Investig 2019 Jan 13. Epub 2019 Jan 13.

Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan.

Unimolecular peptide-based dual agonists against glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) have been gaining much attention recently as novel anti-diabetic agents that can potentially control glycaemia and bodyweight. While glucagon-like Peptide (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) both enhance insulin secretion and subsequently ameliorate postprandial glucose excursion, most research has focused on GLP-1R as a therapeutic target for type 2 diabetes. This is partly because the effects of GIPR activation on glycemia and bodyweight have been controversial. Read More

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http://dx.doi.org/10.1111/jdi.13005DOI Listing
January 2019

Berberine and barberry (Berberis vulgaris): A clinical review.

Phytother Res 2019 Jan 13. Epub 2019 Jan 13.

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Barberry (Berberis vulgaris L.) has different medicinal applications in folk medicine of Iran. Berberine, an alkaloid constituent of this plant, is present in the roots, rhizomes, stem, and bark of B. Read More

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http://dx.doi.org/10.1002/ptr.6252DOI Listing
January 2019

Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial.

Biol Trace Elem Res 2019 Jan 14. Epub 2019 Jan 14.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.

This study was carried out to evaluate the effects of selenium supplementation on glycemic control, lipid profiles, and biomarkers of inflammation and oxidative stress in patients undergoing for coronary artery bypass grafting (CABG) surgery. This randomized, double-blind, placebo-controlled trial was performed among 33 patients undergoing for CABG surgery, aged 40-85 years old. Subjects were randomly allocated into two groups to intake either 200 μg/day selenium supplements as selenium yeast (n = 17) or placebo (n = 16) for 4 weeks. Read More

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http://dx.doi.org/10.1007/s12011-019-1636-7DOI Listing
January 2019

Cinnamon Polyphenol Extract and Insulin Regulate Diacylglycerol Acyltransferase Gene Expression in Mouse Adipocytes and Macrophages.

Plant Foods Hum Nutr 2019 Jan 14. Epub 2019 Jan 14.

PolyChrom Technology, LLC, Edgewater, MD, 21037, USA.

Cinnamon polyphenol extract (CPE) improves people with insulin resistance. The objective was to investigate CPE and insulin on diacylglycerol acyltransferase (DGAT) gene expression important for lipid biosynthesis and compared it to anti-inflammatory tristetraprolin/zinc finger protein 36 (TTP/ZFP36) gene expression known to be regulated by both agents. Mouse 3T3-L1 adipocytes and RAW264. Read More

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http://dx.doi.org/10.1007/s11130-018-0709-7DOI Listing
January 2019

Relation of the degree of obesity in childhood to adipose tissue insulin resistance.

Acta Diabetol 2019 Jan 12. Epub 2019 Jan 12.

Department of Pediatrics, Ruth Rappaport Children's Hospital, Rambam Medical Center, Haifa, Israel.

Aims: In this study, we investigated whether adipose tissue insulin resistance (IR) is affected by the degree of obesity during the fasting and post-prandial state, independent of glucose tolerance among obese children and adolescents. We also tested whether systemic subclinical inflammation is associated with adipose tissue IR.

Methods: Subjects were recruited to the Yale Pathophysiology of Type 2 Diabetes in Youth Study (NCT01967849). Read More

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http://dx.doi.org/10.1007/s00592-018-01285-3DOI Listing
January 2019

Comparative study of the effect of atorvastatin and fenofibrate on high-density lipoprotein cholesterol levels in patients with type 2 diabetes.

J Adv Pharm Technol Res 2018 Oct-Dec;9(4):135-138

Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Diabetes is the most common metabolic disease. Type 2 diabetes is a variable combination of insulin resistance and disorder in insulin secretion, leading to disorder of lipids and plasma lipoproteins. The most common pattern of dyslipidemia in diabetic is high triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C). Read More

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http://dx.doi.org/10.4103/japtr.JAPTR_314_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302688PMC
January 2019

Uropathogens antibiotic resistance patterns among type 2 diabetic patients in Kisii Teaching and Referral Hospital, Kenya.

Pan Afr Med J 2018 23;30:286. Epub 2018 Aug 23.

Department of Medical Laboratory Sciences, Kenyatta University, Nairobi, Kenya.

Introduction: Non-insulin dependent diabetes mellitus is a major risk factor for urinary tract infections. Irrational use of antibiotics has led to the emergency of uropathogens resistant to available antibiotics. The main objective was to determine the bacterial causative agents of urinary tract infections and their antibiotic resistance patterns. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.286.15380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317395PMC
August 2018
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A Contemporary Overview of PPARα/γ Dual Agonists for the Management of Diabetic Dyslipidemia.

Curr Mol Pharmacol 2019 Jan 11. Epub 2019 Jan 11.

J.K.K. Nattraja College of Pharmacy, Kumarapalayam 638183. India.

Background: Diabetes mellitus and concomitant dyslipidemia, being referred to as 'diabetic dyslipidemia', are the foremost detrimental factors documented to play a pivotal role in cardiovascular illness. Diabetic dyslipidemia is associated with insulin resistance, high plasma triglyceride levels, low HDL-cholesterol concentration and elevated small dense LDL-cholesterol particles. Maintaining an optimal glucose and lipid levels in patients afflicted with diabetic dyslipidemia could be a major task that might require a well-planned diet-management system and regular physical activity, or otherwise an intake of a combined antidiabetic and antihyperlipidemic medications. Read More

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http://dx.doi.org/10.2174/1874467212666190111165015DOI Listing
January 2019

Metabolic syndrome in overweight or obese children and adolescents based on own material Abstract Key words.

Dev Period Med 2018 ;22(4):351-357

Department of Gastroenterology, Allergology and Pediatrics, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.

Objective: Aim: To assess the prevalence of metabolic syndrome (MS) components in overweight or obese children and adolescents, as well as analyze the risk factors of its occurrence.

Patients And Methods: Material and methods: The study was conducted in a group of 70 children and adolescents aged 5-18 hospitalized in the Department of Gastroenterology, Allergology and Pediatrics, Polish Mother's Memorial Hospital - Research Institute in Lodz (Poland) based on the results of medical histories, physical examination, biochemical investigation, and calculation of the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index.

Results: Results: MS was diagnosed in 14 children (20%). Read More

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January 2018

High-intensity breastfeeding improves insulin sensitivity during early postpartum period in obese women with gestational diabetes.

Diabetes Metab Res Rev 2019 Jan 12:e3127. Epub 2019 Jan 12.

Dept Obstetrics and Gynecology, Kanmon Medical Center, Shimonoseki, Yamaguchi Prefecture, Japan.

Aim: TO INVESTIGATE WHETHER HIGH-INTENSITY BREASTFEEDING (HIB) REDUCES INSULIN RESISTANCE DURING EARLY POSTPARTUM PERIOD IN WOMEN WITH GESTATIONAL DIABETES (GDM), INDEPENDENT OF POSTPARTUM WEIGHT CHANGE (PWC).: MATERIALS AND METHODS: In this multicenter prospective study, we included Japanese women with GDM who underwent a 75-g oral glucose tolerance test (OGTT) during early postpartum. We measured plasma insulin during OGTT to obtain a homeostasis model of assessment of insulin resistance (HOMA-IR). Read More

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http://doi.wiley.com/10.1002/dmrr.3127
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http://dx.doi.org/10.1002/dmrr.3127DOI Listing
January 2019
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Revisiting the Cardiotoxic Effect of Chloroquine.

Cardiovasc Drugs Ther 2019 Jan 11. Epub 2019 Jan 11.

Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

Purpose: Cardiotoxicity is a well-known side effect of chloroquine. Several studies have proposed chloroquine as a potential anti-diabetic treatment but do not address this problem. The current study investigated the effect of ex vivo chloroquine treatment on (1) heart function and glucose uptake, (2) mitochondrial function and (3) in vivo treatment on heart function. Read More

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http://link.springer.com/10.1007/s10557-018-06847-9
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http://dx.doi.org/10.1007/s10557-018-06847-9DOI Listing
January 2019
1 Read

Serum profile of cytokines and their genetic variants in metabolic syndrome and healthy subjects: a comparative study.

Biosci Rep 2019 Jan 11. Epub 2019 Jan 11.

University of Health sciences, Lahore, Department of Physiology & Cell Biology, Khayaban-e-jamia Punjab, University of Health Sciences, Lahore, Lahore, 54600, Pakistan.

To identify genetic variants in promoter areas of IL-6 -174 G>C and TNF-α -308 G>A in metabolic syndrome (Met S) and controls and associate them with Met S and serum cytokine levels. It was a cross-sectional study, including 224 cases of Met S and 200 controls. A fasting blood sample was taken and biochemical parameters including serum glucose, insulin, lipid profile, IL-6 and TNF-α were measured. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20181202
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http://dx.doi.org/10.1042/BSR20181202DOI Listing
January 2019
1 Read

The influence of the rs1137101 genotypes of leptin receptor gene on the demographic and metabolic profile of normal Saudi females and those suffering from polycystic ovarian syndrome.

BMC Womens Health 2019 Jan 11;19(1):10. Epub 2019 Jan 11.

Central Laboratory, Female Center for Scientific and Medical Colleges, King Saud University, Riyadh, Saudi Arabia.

Background: Polycystic ovarian syndrome (PCOS) is of frequent occurrence in Saudi females and is often associated with obesity, insulin resistance, hypogonadotropic hypogonadism, and infertility. Since these features are also associated with leptin receptor (LEP-R) deficiency, several studies have attempted to link LEP-R gene polymorphisms to PCOS.

Methods: The purpose of this study is to assess the possible association of LEP-R gene polymorphism (rs1137101) with the main obesity-linked metabolic parameters in Saudi female patients affected by PCOS. Read More

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https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12905-018-0706-xDOI Listing
January 2019
1 Read

Circulating neuregulin-1 levels in polycystic ovary syndrome.

Authors:
Haldun Arpacı

J Obstet Gynaecol 2019 Jan 11:1-6. Epub 2019 Jan 11.

a Department of Obstetrics and Gynecology, School of Medicine , Kafkas University , Kars , Turkey.

Neuregulin-1 (NRG1) has been shown to be associated with the regulation of inflammation and ovulation. The aim of this study was to investigate the relationship between serum NRG1 levels and various clinical and metabolic parameters in women with polycystic ovary syndrome (PCOS). This case-controlled study included 38 women with PCOS and 46 age and body mass index (BMI)-matched controls without PCOS. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2018.1
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http://dx.doi.org/10.1080/01443615.2018.1519530DOI Listing
January 2019
1 Read

Obesity, Leptin and Breast Cancer: Epidemiological Evidence and Proposed Mechanisms.

Cancers (Basel) 2019 Jan 9;11(1). Epub 2019 Jan 9.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.

The prevalence of obesity has been steadily increasing over the past few decades in several developed and developing countries, with resultant hazardous health implications. Substantial epidemiological evidence has shown that excessive adiposity strongly influences risk, prognosis, and progression of various malignancies, including breast cancer. Indeed, it is now well recognized that obesity is a complex physiologic state associated with multiple molecular changes capable of modulating the behavior of breast tumor cells as well of the surrounding microenvironment. Read More

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http://www.mdpi.com/2072-6694/11/1/62
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http://dx.doi.org/10.3390/cancers11010062DOI Listing
January 2019
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Pyridostigmine alleviates cardiac dysfunction via improving mitochondrial cristae shape in a mouse model of metabolic syndrome.

Free Radic Biol Med 2019 Jan 10;134:119-132. Epub 2019 Jan 10.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, PO Box 77#, No.76 Yanta West Road, Xi'an City, 710061, Shaanxi Province, PR China. Electronic address:

Insulin resistance and autonomic imbalance are important pathological processes in metabolic syndrome-induced cardiac remodeling. Recent studies determined that disruption of mitochondrial cristae shape is associated with myocardial ischemia; however, the change in cristae shape in metabolic syndrome-induced cardiac remodeling remains unclear. This study determined the effect of pyridostigmine (PYR), which reversibly inhibits cholinesterase to improve autonomic imbalance, on high-fat diet (HFD)-induced cardiac insulin resistance and explored the potential effect on the shape of mitochondrial cristae. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915849183223
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http://dx.doi.org/10.1016/j.freeradbiomed.2019.01.011DOI Listing
January 2019
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Non-targeted Metabolomic Analysis of Skeletal Muscle in a Dehydroepiandrosterone-Induced Mouse Model of Polycystic Ovary Syndrome.

Mol Reprod Dev 2019 Jan 11. Epub 2019 Jan 11.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy and an important metabolic disorder in women of reproductive age. Insulin resistance is one of its most important clinical features in PCOS patients. Androgen excess-induced mitochondrial dysfunction contributes to skeletal muscle insulin resistance in dehydroepiandrosterone (DHEA)-induced PCOS mice. Read More

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http://doi.wiley.com/10.1002/mrd.23111
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http://dx.doi.org/10.1002/mrd.23111DOI Listing
January 2019
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Acupuncture and related techniques for type 2 diabetes mellitus: A systematic review protocol.

Medicine (Baltimore) 2019 Jan;98(2):e14059

Evidence-based Medicine Research Center, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi.

Background: Type 2 diabetes mellitus (T2DM) is a major global health problem. As a complementary treatment, acupuncture and related techniques are widely used to treat metabolic and endocrine diseases, but their efficacy and safety for T2DM are yet to be established. This systematic review will qualitatively and quantitatively summarize the current randomized controlled trial (RCT) evidence regarding the efficacy and safety of acupuncture and related techniques in patients with T2DM. Read More

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http://dx.doi.org/10.1097/MD.0000000000014059DOI Listing
January 2019
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[Antidiabetic role of high density lipoproteins].

Biomed Khim 2018 Nov;64(6):463-471

Institute of Biochemistry, Federal Research Center of Fundamental and Translation Medicine, Novosibirsk, Russia.

Disturbance in lipid metabolism can be both a cause and a consequence of the development of diabetes mellitus (DM). One of the most informative indicator of lipid metabolism is the ratio of atherogenic and antiatherogenic fractions of lipoproteins and their protein components. The review summarizes literature data and own results indicating the important role of high-density lipoprotein (HDL) and their main protein component, apolipoprotein A-I (apoA-I), in the pathogenesis of type 2 DM. Read More

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http://dx.doi.org/10.18097/PBMC20186406463DOI Listing
November 2018
1 Read

Higher levels of IL-18 in patients with prediabetes compared to obese normoglycaemic controls.

Arch Physiol Biochem 2019 Jan 11:1-4. Epub 2019 Jan 11.

c Laboratory of Tumor Immunology and Cell Therapy , Hyogo College of Medicine , Tokyo , Japan.

Background: Overweight and obesity are linked to low-grade chronic inflammation that can impair normal insulin function and induce insulin resistance. The aim of this study was to compare IL-18 levels between patients with prediabetes and obese normoglycaemic controls.

Patients And Methods: In this study, we included 131 patients with mean age 54. Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1555667DOI Listing
January 2019
1 Read

Fish Oil Protects Wild Type and Uncoupling Protein 1 Deficient Mice from Obesity and Glucose Intolerance by Increasing Energy Expenditure.

Mol Nutr Food Res 2019 Jan 11:e1800813. Epub 2019 Jan 11.

T. E. Oliveira, É. Castro, T. Belchior, M. L. Andrade, A. B. Chaves-Filho, A. S. Peixoto, M. F. Moreno, M. Ortiz Silva, R. J. Moreira, W. T. Festuccia, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil, 05508-000.

Scope: We investigated the mechanisms and involvement of uncoupling protein 1 (UCP1) in the protection from obesity and insulin resistance induced by intake of high-fat diet rich in omega 3 (n-3) fatty acids.

Methods And Results: C57BL/6J mice were fed either a low-fat (control group) or one of two isocaloric high-fat diets containing either lard (HFD) or fish oil (HFN3) as fat source and evaluated for body weight, adiposity, energy expenditure, glucose homeostasis and inguinal white and interscapular brown adipose tissues (iWAT and iBAT, respectively) gene expression, lipidome and mitochondrial bioenergetics. HFN3 intake protected from obesity, glucose and insulin intolerances and hyperinsulinemia. Read More

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http://doi.wiley.com/10.1002/mnfr.201800813
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http://dx.doi.org/10.1002/mnfr.201800813DOI Listing
January 2019
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Association of Serum 25-Hydroxyvitamin D Concentrations With Glucose Profiles in Male Collegiate Football Athletes.

Int J Sport Nutr Exerc Metab 2019 Jan 11:1-23. Epub 2019 Jan 11.

5 Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan.

Low serum 25-hydroxyvitamin D [25(OH)D] concentrations are associated with high risk of insulin resistance and type 2 diabetes mellitus (T2DM) in adults. However, it is unknown whether this is the case in American collegiate football and rugby athletes. This study investigated the associations between serum 25(OH)D concentrations and glucose profiles in male collegiate football athletes. Read More

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https://journals.humankinetics.com/doi/10.1123/ijsnem.2018-0
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http://dx.doi.org/10.1123/ijsnem.2018-0225DOI Listing
January 2019
1 Read

Increased Dynamin-Related Protein 1-Dependent Mitochondrial Fission Contributes to High-Fat Diet-Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts.

Mol Nutr Food Res 2019 Jan 10:e1801322. Epub 2019 Jan 10.

Center for Regenerative Medicine, Institute for Translational Medicine, Qingdao University, Qingdao, 266021, China.

Scope: High-fat diet-induced insulin resistance is a major contributor to the pathogenesis of cardiovascular diseases. However, the molecular mechanisms that regulate cardiac insulin signalling are not fully understood. We investigated the regulatory role of tafazzin in the hearts of high-fat diet-fed mice. Read More

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http://doi.wiley.com/10.1002/mnfr.201801322
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http://dx.doi.org/10.1002/mnfr.201801322DOI Listing
January 2019
1 Read

An accumulation of muscle macrophages is accompanied by altered insulin sensitivity after reduced-activity and recovery.

Acta Physiol (Oxf) 2019 Jan 10:e13251. Epub 2019 Jan 10.

University of Utah, Departments of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, Utah, 84018, U.S.A.

Mechanisms underlying physical inactivity-induced insulin resistance are not well understood. In addition to a role in muscle repair, immune cell populations such as macrophages may regulate insulin sensitivity.

Aim: To examine if the dynamic changes in insulin sensitivity during and after recovery from reduced physical activity corresponded to changes in skeletal muscle macrophages. Read More

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http://doi.wiley.com/10.1111/apha.13251
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http://dx.doi.org/10.1111/apha.13251DOI Listing
January 2019
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Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.

Fish Physiol Biochem 2019 Jan 11. Epub 2019 Jan 11.

Key Laboratory for Genetic Breeding of Aquatic Animals and Aquaculture Biology, Freshwater Fisheries Research Center (FFRC), Chinese Academy of Fishery Sciences (CAFS), Wuxi, 214081, China.

The present study evaluated the mechanisms governing insulin signaling, glucose metabolism, and lipogenesis in juvenile fish fed with different dietary leucine levels. Fish were fed six practical diets with graded leucine levels ranging from 0.90 to 2. Read More

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http://link.springer.com/10.1007/s10695-018-0594-x
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http://dx.doi.org/10.1007/s10695-018-0594-xDOI Listing
January 2019
5 Reads

Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting.

Neurosci Bull 2019 Jan 10. Epub 2019 Jan 10.

Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of the Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Hyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer's disease (AD), and insulin-resistance is commonly seen in patients with Hhcy. Liraglutide (Lir), a glucagon-like peptide that increases the secretion and sensitivity of insulin, has a neurotrophic or neuroprotective effect. However, it is not known whether Lir ameliorates the AD-like pathology and memory deficit induced by Hhcy. Read More

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http://link.springer.com/10.1007/s12264-018-00336-7
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http://dx.doi.org/10.1007/s12264-018-00336-7DOI Listing
January 2019
1 Read

Changes of the Fatty Acid Profile in Erythrocyte Membranes of Patients following 6-Month Dietary Intervention Aimed at the Regression of Nonalcoholic Fatty Liver Disease (NAFLD).

Can J Gastroenterol Hepatol 2018 4;2018:5856201. Epub 2018 Dec 4.

Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Szczecin, Poland.

Background: Nonalcoholic fatty liver disease (NAFLD) is closely related to the metabolism disorders of fatty acids. The pathogenesis of the disease includes an increased concentration of FFA in blood, an increase in the biosynthesis of fatty acids, and disorders in the process of -oxidation.

Objective: The aim of the study was to analyze the fatty acids in erythrocyte membranes among 55 patients with NAFLD who were subjected to a 6-month dietary intervention in order to reduce fatty liver. Read More

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https://www.hindawi.com/journals/cjgh/2018/5856201/
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http://dx.doi.org/10.1155/2018/5856201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304595PMC
December 2018
1 Read

Non-invasive prediction of non-alcoholic steatohepatitis in Japanese patients with morbid obesity by artificial intelligence using rule extraction technology.

World J Hepatol 2018 Dec;10(12):934-943

Weight Loss and Metabolic Surgery Center, Yotsuya Medical Cube, Tokyo 102-0084, Japan.

Aim: To construct a non-invasive prediction algorithm for predicting non-alcoholic steatohepatitis (NASH), we investigated Japanese morbidly obese patients using artificial intelligence with rule extraction technology.

Methods: Consecutive patients who required bariatric surgery underwent a liver biopsy during the operation. Standard clinical, anthropometric, biochemical measurements were used as parameters to predict NASH and were analyzed using rule extraction technology. Read More

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https://www.wjgnet.com/1948-5182/full/v10/i12/934.htm
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http://dx.doi.org/10.4254/wjh.v10.i12.934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323515PMC
December 2018
1 Read

Insulin Resistance in Gastroesophageal Reflux Disease.

Acta Med Indones 2018 Oct;50(4):336-342

Faculty of Medicine Universitas Indonesia.

Insulin resistance is the disturbance of glucose regulation characterized by higher insulin level. In clinical context, insulin resistance can manifest as abnormalities that are related with cardiovascular event risk, known as metabolic syndrome. Several studies had reported that insulin resistance was associated with erosive esophagitis in patients with gastroesophageal reflux disease (GERD). Read More

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October 2018
4 Reads

The Association Between Parents History of Type 2 Diabetes with Metabolic Syndrome Component and Insulin Resistance in Non-Diabetic Young Adult Male.

Acta Med Indones 2018 Oct;50(4):309-313

Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Background: the familial nature of type 2 diabetes is manifested by the presence of insulin resistance in non-diabetic first degree relatives. Most of these studies have been performed in middle-aged and there is only few published studies in young age individuals and adolescents. This study aimed to determine the relationship between parents history of type-2 diabetes with metabolic syndrome component and insulin resistance in adolescent non-diabetic subjects. Read More

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October 2018
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Analysis of sphingolipid composition in human vitreous from control and diabetic individuals.

J Diabetes Complications 2018 Dec 14. Epub 2018 Dec 14.

The University of Tennessee Health Science Center, Department of Ophthalmology, Memphis, TN 38163, USA; The University of Tennessee Health Science Center, Department of Anatomy and Neurobiology, Memphis, TN 38163, USA; The University of Oklahoma Health Science Center, Department of Ophthalmology, Oklahoma City, OK 73104, USA. Electronic address:

Objective: Sphingolipids have a fundamental role in many cellular processes, and they have been implicated in insulin resistance and Diabetes Mellitus (DM) and its complications, including diabetic retinopathy (DR). Little is known about how bioactive sphingolipids relate to retinopathies in human DM. In this study, we analyzed the sphingolipid composition of type 2 diabetic (T2DM) and non-diabetic human vitreous samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183067
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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.005DOI Listing
December 2018
1 Read

Dietary fat composition: replacement of saturated fatty acids with PUFA as a public health strategy, with an emphasis on α-linolenic acid.

Proc Nutr Soc 2019 Jan 11:1-12. Epub 2019 Jan 11.

Nutrigenomics Research Group,UCD Conway Institute,Belfield,Dublin 4,Ireland.

SFA intakes have decreased in recent years, both in Ireland and across other European countries; however a large proportion of the population are still not meeting the SFA recommendation of <10% of total energy (TE). High SFA intakes have been associated with increased CVD and type-2 diabetes (T2D) risk, due to alterations in cholesterol homoeostasis and adipose tissue inflammation. PUFA, in particular EPA and DHA, have been associated with health benefits, including anti-inflammatory effects. Read More

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http://dx.doi.org/10.1017/S0029665118002793DOI Listing
January 2019
1 Read

The Role of Vildagliptin in Treating Hypertension Through Modulating Serum VEGF in Diabetic Hypertensive Patients.

J Cardiovasc Pharmacol Ther 2019 Jan 10:1074248418817345. Epub 2019 Jan 10.

6 Faculty of pharmacy, Cairo University, Giza, Egypt.

Background:: Several trials have reported that dipeptidyl peptidase-4 (DPP-4) inhibitors are used to improve endothelial function in addition to treating type 2 diabetes (T2DM). The current study investigated the effects of vildagliptin, DPP-4 inhibitor, compared to metformin on endothelial function and blood pressure through vascular endothelial growth factor (VEGF) modulation in patients with T2DM and hypertension.

Methods:: This study was designed as a randomized controlled parallel study. Read More

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http://dx.doi.org/10.1177/1074248418817345DOI Listing
January 2019
1 Read

Feasibility and Acceptability of Metformin to Augment Low Milk Supply: A Pilot Randomized Controlled Trial.

J Hum Lact 2019 Jan 10:890334418819465. Epub 2019 Jan 10.

1 University of Cincinnati, Cincinnati, OH, USA.

Background:: Metformin improves insulin action, but feasibility in treating low milk supply is unknown.

Research Aim:: To determine the feasibility of a metformin- versus-placebo definitive randomized clinical trial in women with low milk production and signs of insulin resistance.

Methods:: Pilot trial criteria included: Mother 1-8 weeks postpartum (ideally 1-2 weeks), low milk production, and ≥1 insulin resistance sign; and singleton, healthy, term infant. Read More

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http://dx.doi.org/10.1177/0890334418819465DOI Listing
January 2019
1 Read

Maternal prebiotic supplementation reduces fatty liver development in offspring through altered microbial and metabolomic profiles in rats.

FASEB J 2019 Jan 10:fj201801551R. Epub 2019 Jan 10.

Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

A maternal high-fat/sucrose diet, in the presence of maternal obesity, can program increased susceptibility to obesity and metabolic disease in offspring. In particular, nonalcoholic fatty liver disease risk is associated with poor maternal nutrition and obesity status, which may manifest via alterations in gut microbiota. Here, we report that in a preclinical model of diet-induced maternal obesity, maternal supplementation of a high-fat/sucrose diet with the prebiotic oligofructose improves glucose tolerance, insulin sensitivity, and hepatic steatosis in offspring following a long-term high-fat/sucrose dietary challenge compared with offspring of untreated dams. Read More

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https://www.fasebj.org/doi/10.1096/fj.201801551R
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http://dx.doi.org/10.1096/fj.201801551RDOI Listing
January 2019
1 Read

Relationship between regional hepatic glucose metabolism and regional distribution of hepatic fat.

Nucl Med Commun 2019 Jan 8. Epub 2019 Jan 8.

Brighton and Sussex University Hospitals NHS Trust.

Aim: Hepatic steatosis is associated with insulin resistance and hyperinsulinaemia. Insulin stimulates hepatic glucokinase, even in insulin resistance, so hepatic glucose uptake is increased in hepatic steatosis. The study hypothesis was that hepatic glucose uptake is also influenced locally by fat, the hepatic distribution of which is heterogeneous. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000968DOI Listing
January 2019
1 Read

Polysaccharides from fermented Momordica charantia ameliorate obesity in high-fat induced obese rats.

Food Funct 2019 Jan 10. Epub 2019 Jan 10.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, China.

Momordica charantia (M. charantia) has been widely used to treat obesity due to its bioactive ingredients. This research aimed to investigate the anti-obesity effect of polysaccharides (FP) from fermented M. Read More

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http://xlink.rsc.org/?DOI=C8FO01609G
Publisher Site
http://dx.doi.org/10.1039/c8fo01609gDOI Listing
January 2019
3 Reads