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    Food restriction promotes damage reduction in rat models of type 2 diabetes mellitus.
    PLoS One 2018 20;13(6):e0199479. Epub 2018 Jun 20.
    Department of Morphological Sciences, State University of Maringá, Paraná, Brazil.
    There are several animal models of type 2 diabetes mellitus induction but the comparison between models is scarce. Food restriction generates benefits, such as reducing oxidative stress, but there are few studies on its effects on diabetes. The objective of this study is to evaluate the differences in physiological and biochemical parameters between diabetes models and their responses to food restriction. Read More

    Heat Shock Protein 72 Regulates Hepatic Lipid Accumulation.
    Am J Physiol Regul Integr Comp Physiol 2018 Jun 20. Epub 2018 Jun 20.
    Molecular and Integrative Physiology, University of Kansas Medical Center, United States.
    Induction of the chaperone Heat Shock Protein 72 (HSP72) through heat treatment, exercise, or overexpression improves glucose tolerance and mitochondrial function in skeletal muscle. Less is known about HSP72 function in the liver where lipid accumulation can result in insulin resistance and Nonalcoholic Fatty Liver Disease (NAFLD). The purpose of this study was 1) to determine whether weekly in vivo heat treatment (HT) induces hepatic HSP72 and improves glucose tolerance in rats fed a high-fat diet (HFD) and 2) to determine the ability of HSP72 to protect against lipid accumulation and mitochondrial dysfunction in primary hepatocytes. Read More

    Influence of oophorectomy on glycemia and lipidogram.
    Acta Cir Bras 2018 May;33(5):415-419
    Department of Gynecology, School of Medicine, UEPA, Belem, PA, Brazil.
    Purpose: To verify the influence of oophorectomy on lipidogram and glycemia.

    Methods: Fifty six female rats were divided into the following 7 groups (n = 8): group 1 - sham group, group 2 - oophorectomy 30 days, group 3 - oophorectomy 35 days, group 4 - oophorectomy 40 days, group 5 - oophorectomy 45 days, group 6 - oophorectomy 70 days, group 7 - oophorectomy 55 days. Animals were following by number of days according the group. Read More

    Exenatide ameliorates hepatic steatosis and attenuates fat mass and FTO gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease.
    Braz J Med Biol Res 2018 14;51(8):e7299. Epub 2018 Jun 14.
    Department of Endocrinology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
    Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resistance and attenuate hepatic steatosis but the specific underlying mechanism is unclear. This study was designed to investigate the underlying molecular mechanisms of exenatide therapy on NAFLD. Read More

    Hypoxic Training Improves Normoxic Glucose Tolerance in Adolescents with Obesity.
    Med Sci Sports Exerc 2018 Jun 20. Epub 2018 Jun 20.
    Institute of Neuroscience, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
    Purpose: To test whether environmental hypoxia could potentiate the effects of exercise training on glucose metabolism and insulin sensitivity.

    Methods: Fourteen adolescents with obesity were assigned to 6 weeks of exercise training either in normoxic or in hypoxic conditions (FiO2 15%). Adolescents trained 3x/w for 50-60min, including endurance and resistance exercises. Read More

    Acid Sphingomyelinase Down-Regulation Alleviates Vascular Endothelial Insulin Resistance in Diabetic Rats.
    Basic Clin Pharmacol Toxicol 2018 Jun 19. Epub 2018 Jun 19.
    Department of Clinical Pharmacy, School of Preclinical Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
    Insulin resistance in endothelial cells contributes to the development of cardiovascular disease in patients with type 2 diabetes. Acid sphingomyelinase (ASM) is a soluble glycoprotein which plays a vital role in the development and progression of various diseases such as cardiovascular and metabolic diseases. However, it remains unknown if ASM regulates insulin resistance in vascular endothelial cells in type 2 diabetes. Read More

    Dapagliflozin, a SGLT2 inhibitor, slows the progression of renal complications through the suppression of renal inflammation, ER stress, and apoptosis in pre-diabetic rats.
    Diabetes Obes Metab 2018 Jun 19. Epub 2018 Jun 19.
    Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
    Background And Aims: The sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin has been shown to exert both anti-diabetic and anti-obesity effects in metabolic syndrome. However, the effects of dapagliflozin on the renal complications associated with metabolic dysfunction in diet-induced obesity (DIO) are not fully understood. In this study, to work towards a resolution of these issues, we evaluated the renoprotective roles of dapagliflozin in pre-diabetic rats. Read More

    Inflammation of brown/beige adipose tissues in obesity and metabolic disease.
    J Intern Med 2018 Jun 20. Epub 2018 Jun 20.
    Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the, University of Barcelona (IBUB), , and CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain.
    Many of the comorbidities of obesity, including type 2 diabetes and cardiovascular diseases are related to the low-grade chronic inflammation of white adipose tissue. Under white adipocyte stress, local infiltration of immune cells and enhanced production of pro-inflammatory cytokines together reduce metabolic flexibility and lead to insulin resistance in obesity. Whereas white adipocytes act in energy storage, brown and beige adipocytes specialize in energy expenditure. Read More

    Beneficial effect of apple vinegar on reproductive parameters in male rat model of nonalcoholic fatty liver disease.
    Andrologia 2018 Jun 19:e13065. Epub 2018 Jun 19.
    Cellular & Molecular Research Center, School Of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
    Nonalcoholic fatty liver disease (NAFLD) is associated with low testosterone levels in serum. The aim of this study was to evaluate the effect of apple vinegar on fertility indices in a rat model of NAFLD. To study this effect, 32 adult male rats were divided into four groups: A-normal diet, B-high-fat diet (HFD), C-apple vinegar and D-HFD plus apple vinegar. Read More

    Innate immune cells in the adipose tissue.
    Rev Endocr Metab Disord 2018 Jun 19. Epub 2018 Jun 19.
    Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
    Immune cells are present in the adipose tissue (AT) and regulate its function. Under lean conditions, immune cells predominantly of type 2 immunity, including eosinophils, M2-like anti-inflammatory macrophages and innate lymphoid cells 2, contribute to the maintenance of metabolic homeostasis within the AT. In the course of obesity, pro-inflammatory immune cells, such as M1-like macrophages, prevail in the AT. Read More

    Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity.
    Molecules 2018 Jun 19;23(6). Epub 2018 Jun 19.
    Institute of Physiology of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
    Fatty acid (FA)-stimulated insulin secretion (FASIS) is reviewed here in contrast to type 2 diabetes etiology, resulting from FA overload, oxidative stress, intermediate hyperinsulinemia, and inflammation, all converging into insulin resistance. Focusing on pancreatic islet β-cells, we compare the physiological FA roles with the pathological ones. Considering FAs not as mere amplifiers of glucose-stimulated insulin secretion (GSIS), but as parallel insulin granule exocytosis inductors, partly independent of the K channel closure, we describe the FA initiating roles in the prediabetic state that is induced by retardations in the glycerol-3-phosphate (glucose)-promoted glycerol/FA cycle and by the impaired GPR40/FFA1 (free FA1) receptor pathway, specifically in its amplification by the redox-activated mitochondrial phospholipase, iPLA2γ. Read More

    Diagnosis and follow-up of type 2 diabetes in women with PCOS. A role of OGTT?
    Eur J Endocrinol 2018 Jun 19. Epub 2018 Jun 19.
    D Glintborg, Endocrinology, Odense University Hospital, Odense , DK-5000, Denmark.
    Polycystic ovary syndrome (PCOS) is common in premenopausal women. The majority of women with PCOS have insulin resistance and the risk of type 2 diabetes mellitus (T2D) is higher in women with PCOS compared to controls. In non-pregnant women with PCOS, glycemic status may be assessed by oral glucose tolerance test (OGTT), fasting plasma glucose (FPG), or HbA1c. Read More

    No. 362-Ovulation Induction in Polycystic Ovary Syndrome.
    J Obstet Gynaecol Can 2018 Jul;40(7):978-987
    Vancouver, BC.
    Objective: To review current non-pharmacologic and pharmacologic options for ovulation induction in women with polycystic ovary syndrome (PCOS).

    Options: This guideline reviews the evidence for the various options for ovulation induction in PCOS.

    Outcomes: Ovulation, pregnancy and live birth rates, risks, and side effects are the outcomes of interest. Read More

    The involvement and mechanism of febuxostat in non-alcoholic fatty liver disease cells.
    J Biol Regul Homeost Agents 2018 May-Jun;32(3):545-551
    Department of endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
    It has been proved that hyperuricemia is associated with non-alcoholic fatty liver disease (NAFLD). The xanthine oxidase (XO) inhibitor, febuxostat, decreases free fatty acids-induced fat accumulation in HFDT-fed mice. Here, it is shown that febuxostat attenuates fat accumulation and reactive oxygen species (ROS) in HepG2 cells. Read More

    Sarcopenia is associated with the risk of significant liver fibrosis in metabolically unhealthy subjects with chronic hepatitis B.
    Aliment Pharmacol Ther 2018 Jun 19. Epub 2018 Jun 19.
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
    Background: Sarcopenia is significantly associated with the degree of liver fibrosis. This study investigated the influence of sarcopenia on liver fibrosis in individuals with chronic hepatitis B.

    Methods: Data from the Korean National Health and Nutrition Examination Surveys 2008-2011 were analysed. Read More

    Antidiabetic effect of Euterpe oleracea Mart. (açaí) extract and exercise training on high-fat diet and streptozotocin-induced diabetic rats: A positive interaction.
    PLoS One 2018 19;13(6):e0199207. Epub 2018 Jun 19.
    Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.
    A growing body of evidence suggests a protective role of polyphenols and exercise training on the disorders of type 2 diabetes mellitus (T2DM). We aimed to assess the effect of the açaí seed extract (ASE) associated with exercise training on diabetic complications induced by high-fat (HF) diet plus streptozotocin (STZ) in rats. Type 2 diabetes was induced by feeding rats with HF diet (55% fat) for 5 weeks and a single dose of STZ (35 mg/kg i. Read More

    Stress aggravates high-fat-diet-induced insulin resistance via a mechanism that involves the amygdala and is associated with changes in neuroplasticity.
    Neuroendocrinology 2018 Jun 19. Epub 2018 Jun 19.

    Background: The notion that exposure to chronic stress predisposes individuals to develop Type 2 diabetes (T2D) has gained much attention in recent decades. Long-term stress induces neuroadaptation in the amygdala and increases corticosterone levels. Corticosterone, the major stress hormone in rodents, induces insulin resistance and obesity in mice. Read More

    Alterations in the liver of intrauterine growth retarded piglets may predispose to development of insulin resistance and obesity in later life.
    J Physiol Pharmacol 2018 Apr 13;69(2). Epub 2018 Jun 13.
    Veterinary Research Centre and Center for Biomedical Research, Department of Large Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.
    Intrauterine growth retardation (IUGR) leads to increased predisposition to metabolic syndrome in adult life but the mechanisms remain obscure. Considering a significant number of functional similarities, IUGR piglets appear to be a good model to study the development of this syndrome in humans. The aim of the present study was to investigate the ultrastructure and proteomic profile of the liver in IUGR pig neonates to discover early markers of predisposition to obesity and insulin resistance. Read More

    High plasma apolipoprotein B identifies obese subjects who best ameliorate white adipose tissue dysfunction and glucose-induced hyperinsulinemia after a hypocaloric diet.
    Am J Clin Nutr 2018 Jun 18. Epub 2018 Jun 18.
    Institut de Recherches Cliniques de Montréal (IRCM), Montreal, Quebec, Canada.
    Background: To optimize the prevention of type 2 diabetes (T2D), high-risk obese subjects with the best metabolic recovery after a hypocaloric diet should be targeted. Apolipoprotein B lipoproteins (apoB lipoproteins) induce white adipose tissue (WAT) dysfunction, which in turn promotes postprandial hypertriglyceridemia, insulin resistance (IR), and hyperinsulinemia.

    Objective: The aim of this study was to explore whether high plasma apoB, or number of plasma apoB lipoproteins, identifies subjects who best ameliorate WAT dysfunction and related risk factors after a hypocaloric diet. Read More

    Nonalcoholic fatty liver disease and hypertension: coprevalent or corelated?
    Eur J Gastroenterol Hepatol 2018 Jun 18. Epub 2018 Jun 18.
    First Department of Cardiology.
    Objective: To provide a comprehensive review summarizing the existing evidence on the association between nonalcoholic fatty liver disease (NAFLD) and hypertension (HT) independent of other components of metabolic syndrome.

    Methods: We searched the literature through Medline and the Cochrane Library for studies evaluating the relationship between hypertension and fatty liver disease.

    Results: Studies testing this association are limited, but agree that HT and fatty liver disease are inter-related independent of other components of the metabolic syndrome such as obesity and diabetes mellitus. Read More

    Investigation of PhiKZ phage therapy against Pseudomonas aeruginosa in mouse pneumonia model
    Turk J Med Sci 2018 Jun 14;48(3):670-678. Epub 2018 Jun 14.
    Background/aim: The aim of this study was to investigate the effects of PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the Pseudomonas aeruginosa PAO1 strain. The cross-talk between lungs and kidneys was also determined. Materials and methods: The systemic, lung-specific, and kidney-specific inflammation levels and the bacterial load in lung tissue and biochemical parameters were investigated after PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the P. Read More

    Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36.
    J Physiol Biochem 2018 Jun 18. Epub 2018 Jun 18.
    Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic.
    Hypertension, dyslipidemia, and insulin resistance in the spontaneously hypertensive rat (SHR) can be alleviated by rescuing CD36 fatty acid translocase. The present study investigated whether transgenic rescue of CD36 in SHR could affect mitochondrial function and activity of selected metabolic enzymes in the heart. These analyses were conducted on ventricular preparations derived from SHR and from transgenic strain SHR-Cd36 that expresses a functional wild-type CD36. Read More

    Metabolic Surgery for the Treatment of Diabetes Mellitus Positioning of Leading Medical Associations in Mexico.
    Obes Surg 2018 Jun 18. Epub 2018 Jun 18.
    IFSO: International Federation for the Surgery of Obesity and Metabolic Disorders, Mexico, Mexico.
    Introduction: Metabolic surgery (MS) can be a useful therapeutic strategy in patients with type 2 diabetes (DM2) and obesity.

    Objective: To define the place of MS within DM2 treatment in Mexico.

    Methods: A committee of experts consisting of internists and surgeons representing the leading Mexican associations involved in the field was created. Read More

    A study on the altered glycemic and lipid parameters and prevalence of insulin resistance in nonalcoholic fatty liver disease.
    J Family Med Prim Care 2018 Jan-Feb;7(1):93-97
    Department of Family Medicine, Malabar Institute of Medical Sciences, Calicut, Kerala, India.
    Introduction: Nonalcoholic fatty liver disease (NAFLD) is a hepatic disorder that develops in the absence of alcohol intake. Obesity and diabetes are considered risk factors for the development of fatty liver; however, whether fatty liver is the cause or consequence of these conditions is not yet clear. Insulin resistance (IR) is found to be a common risk factor for the development of diabetes, obesity and fatty liver. Read More

    A Case of Concomitant Obstructive Sleep Apnea and Non-Alcoholic Steatohepatitis Treated With CPAP Therapy.
    Gastroenterology Res 2018 Jun 31;11(3):252-259. Epub 2018 May 31.
    Division of Pulmonary Critical Care, Department of Medicine, Bronx Care Health System, Bronx, NY 10457, USA.
    Obstructive sleep apnea syndrome is a disorder of sleep breathing that is a result of recurrent and intermittent hypoxia during sleep induced by the repeated partial or complete collapse of the upper airway, eventually causing chronic intermittent hypoxia. Non-alcoholic fatty liver disease is divided into non-alcoholic fatty liver and non-alcoholic steatohepatitis. Animal and human studies showed that obesity is associated with chronic liver hypoxia, even in the presence of systemic normoxia causing inflammation and release of cytokines. Read More

    Diabetes Mellitus Secondary to Cushing's Disease.
    Front Endocrinol (Lausanne) 2018 5;9:284. Epub 2018 Jun 5.
    Endocrinology Unit, Department of Medicine DIMED, University of Padua, Padua, Italy.
    Associated with important comorbidities that significantly reduce patients' overall wellbeing and life expectancy, Cushing's disease (CD) is the most common cause of endogenous hypercortisolism. Glucocorticoid excess can lead to diabetes, and although its prevalence is probably underestimated, up to 50% of patients with CD have varying degrees of altered glucose metabolism. Fasting glycemia may nevertheless be normal in some patients in whom glucocorticoid excess leads primarily to higher postprandial glucose levels. Read More

    Lixisenatide Versus Insulin Glulisine on Fasting and Postbreakfast Systemic Hemodynamics in Type 2 Diabetes Mellitus Patients.
    Hypertension 2018 Jun 18. Epub 2018 Jun 18.
    From the Department of Internal Medicine, Diabetes Center (L.T., M.H.A.M., M.H.H.K., M.M.S., D.H.v.R.).
    The prolonged treatment effects of a short-acting GLP-1RA (glucagon-like peptide-1 receptor agonist), such as lixisenatide, on fasting and postprandial systemic hemodynamics in type 2 diabetes mellitus patients are unknown. In this secondary analysis, we included 34 overweight insulin glargine-treated type 2 diabetes mellitus patients (mean±SD age, 62±7 years; HbA, 8.0±0. Read More

    Inhibition of CD36 reduces visceral fat accumulation and improves insulin resistance in diet-induced obese BDNF mice.
    J Biol Chem 2018 Jun 18. Epub 2018 Jun 18.
    Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, United States.
    Obesity-induced metabolic dysfunctions increase risk of vascular diseases including type II diabetes and stroke. While managing obesity is an interest to address the worldwide health problem, how genetic variability affects human obesity development and specific targets for obesity-related metabolic disease have not been thoroughly studied. A single nucleotide polymorphism (SNP) in the brain derived neurotropic factor (BDNF) gene that results in the substitution of a valine to a methionine at codon 66 () occurs with a high frequency in humans. Read More

    Positive correlation of galanin with insulin resistance and triglyceride levels in obese children
    Turk J Med Sci 2018 Jun 14;48(3):560-568. Epub 2018 Jun 14.
    Background/aim: Galanin is a neuropeptide that is shown to be involved in the regulation of food intake and glucose homeostasis. The objective of this study was to evaluate the relation of serum galanin levels with anthropometric and metabolic parameters in obese and healthy children. Material and methods: The cross-sectional study consisted of 38 obese children (mean age: 11. Read More

    Obesity-Related Metabolic Risk in Sedentary Hispanic Adolescent Girls with Normal BMI.
    Children (Basel) 2018 Jun 15;5(6). Epub 2018 Jun 15.
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
    Hispanic adolescent girls with normal BMI frequently have high body fat %. Without knowledge of body fat content and distribution, their risk for metabolic complications is unknown. We measured metabolic risk indicators and abdominal fat distribution in post-pubertal Hispanic adolescent girls with Normal BMI (N-BMI: BMI < 85th percentile) and compared these indicators between girls with Normal BMI and High Fat content (N-BMI-HF: body fat ≥ 27%; = 15) and Normal BMI and Normal Fat content (N-BMI-NF: body fat < 27%; = 8). Read More

    Habitual Fructose Intake Relates to Insulin Sensitivity and Fatty Liver Index in Recent-Onset Type 2 Diabetes Patients and Individuals without Diabetes.
    Nutrients 2018 Jun 15;10(6). Epub 2018 Jun 15.
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, 40225 Düsseldorf, Germany.
    The association between the amount and sources of fructose intake with insulin sensitivity and liver fat needs further elucidation. This study aimed at examining whether habitual intake of sucrose plus non-sucrose bound as well as of non-sucrose bound fructose (total fructose, fruit-derived, juice-derived, sugar sweetened beverages (SSB)-derived fructose) is cross-sectionally associated with insulin sensitivity and fatty liver index (FLI). Fructose intake was estimated using the EPIC food frequency questionnaire from 161 participants with type 2 diabetes (T2D) in the ongoing German Diabetes Study (GDS) (age 53 ± 9 years; HbA1c 6. Read More

    Ameliorates Non-Alcoholic Steatosis by Upregulating Energy Metabolizing Enzymes in the Liver.
    J Clin Med 2018 Jun 15;7(6). Epub 2018 Jun 15.
    Bio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 52727, Korea.
    Non-alcoholic steatosis is a common health problem worldwide due to altered food habits and life styles, and it is intimately linked with various metabolic disorders. In the present study, we investigated the molecular mechanism of (GL) against the development of non-alcoholic steatosis using in vivo and in vitro settings. C57BL/6 mice fed with normal diet (ND) or high fat diet (HFD) were administered GL extract or vehicle for 16 weeks. Read More

    The Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Lipid Metabolism, Glucose Homeostasis and Inflammation.
    Int J Mol Sci 2018 Jun 15;19(6). Epub 2018 Jun 15.
    Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba X5000HUA, Argentina.
    Metabolic syndrome (MetS) is a highly prevalent disorder which can be used to identify individuals with a higher risk for cardiovascular disease and type 2 diabetes. This metabolic syndrome is characterized by a combination of physiological, metabolic, and molecular alterations such as insulin resistance, dyslipidemia, and central obesity. The low-density lipoprotein receptor-related protein 1 (LRP1—A member of the LDL receptor family) is an endocytic and signaling receptor that is expressed in several tissues. Read More

    Associations of Genetic Susceptibility to Alzheimer's Disease with Adiposity and Cardiometabolic Risk Factors among Children in a 2-Year Follow-up Study.
    J Alzheimers Dis 2018 Jun 9. Epub 2018 Jun 9.
    Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Finland.
    We investigated the associations of genetic risk score (GRS) for Alzheimer's disease and apolipoprotein E (APOE) ɛ variant with cardiometabolic risk factors during 2-year follow-up in children and whether body fat percentage (BF%) modify these associations. A population-based sample of 469 children (246 boys, 223 girls) at baseline and 398 children (201 boys, 197 girls) at 2-year follow-up participated in the study. Genotyping was performed using the the Illumina Custom Infinium CardioMetabo BeadChip and the Illumina Infinium HumanCoreExome BeadChip. Read More

    Maternal folic acid supplementation with vitamin B deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet.
    FASEB J 2018 Apr 17:fj201701503RR. Epub 2018 Apr 17.
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
    Epidemiologic studies have reported relationships between maternal high folate and/or low B status during pregnancy and greater adiposity and insulin resistance in children. The goal of this study was to determine the effects of maternal folic acid supplementation (10 mg/kg diet), with (50 μg/kg diet) and without B, on adult, female offspring adiposity and glucose homeostasis. Female C57BL/6J mice were fed 1 of 3 diets from weaning and throughout breeding, pregnancy, and lactation: control (2 mg/kg diet folic acid, 50 μg/kg diet B), supplemental folic acid with no B (SFA-B), or supplemental folic acid with adequate B (SFA+B). Read More

    Zmynd17 controls muscle mitochondrial quality and whole-body metabolism.
    FASEB J 2018 Apr 13:fj201701264R. Epub 2018 Apr 13.
    Musculoskeletal Molecular Biology Research Group, Basic and Translational Research Center for Hard Tissue Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Muscle mitochondria are crucial for systemic metabolic function, yet their regulation remains unclear. The zinc finger MYND domain-containing protein 17 (Zmynd17) was recently identified as a muscle-specific gene in mammals. Here, we investigated the role of Zmynd17 in mice. Read More

    [Protective effect and underlying mechanism of cordycepin on non-alcoholic fatty liver in ob/ob mice].
    Yao Xue Xue Bao 2017 01;52(1):106-12
    This study is designed to investigate the protective effect and mechanism of cordycepin on non- alcoholic fatty liver in ob/ob mice. Twelve-week-old male ob/ob mice were divided into 5 groups according to their body weight and blood glucose, and C57BL/6J mice were used in the control group. The animals were orally administered with cordycepin for 7 weeks. Read More

    The associations between the growth hormone/insulin-like growth factor-1 axis, adiponectin, resistin and metabolic profile in children with growth hormone deficiency before and during growth hormone treatment.
    Acta Biochim Pol 2018 18;65(2):333-340. Epub 2018 Jun 18.
    Department of Paediatrics and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
    This study investigated associations between the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis, adiponectin, resistin and metabolic profile in 47 GH-deficient children before and during 12 months of GH treatment. 23 short age-matched children without growth hormone deficiency (GHD) or any genetic or chronic disorders were recruited as controls at baseline. Metabolic evaluation included measurements of adiponectin, resistin, IGF-1, total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, insulin, glycated haemoglobin (HbA1c), thyroid stimulating hormone (TSH) and free thyroxine (free T4) concentrations. Read More

    Transcriptome analysis reveals novel insights into the response of low-dose benzo(a)pyrene exposure in male tilapia.
    Aquat Toxicol 2018 Jun 8;201:162-173. Epub 2018 Jun 8.
    CONACYT, Mexico; Departamento de Recursos del Mar, Cinvestav Unidad Mérida, Mérida, Yucatán 97310, Mexico.
    Despite a wide number of toxicological studies that describe benzo[a]pyrene (BaP) effects, the metabolic mechanisms that underlie these effects in fish are largely unknown. Of great concern is the presence of BaP in aquatic systems, especially those in close proximity to human activity leading to consumption of potentially contaminated foods. BaP is a known carcinogen and it has been reported to have adverse effects on the survival, development and reproduction of fish. Read More

    Discovery of a novel potent peptide agonist to adiponectin receptor 1.
    PLoS One 2018 18;13(6):e0199256. Epub 2018 Jun 18.
    R&D center, EncuraGen Inc, Anyang, Gyeonggi-do, South Korea.
    Activation of adiponectin receptors (AdipoRs) by its natural ligand, adiponectin has been known to be involved in modulating critical metabolic processes such as glucose metabolism and fatty acid oxidation as demonstrated by a number of in vitro and in vivo studies over last two decades. These findings suggest that AdipoRs' agonists could be developed into a potential therapeutic agent for metabolic diseases, such as diabetes mellitus, especially for type II diabetes, a long-term metabolic disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin. Because of limitations in production of biologically active adiponectin, adiponectin-mimetic AdipoRs' agonists have been suggested as alternative ways to expand the opportunity to develop anti-diabetic agents. Read More

    Associations between waist circumference, metabolic risk and executive function in adolescents: A cross-sectional mediation analysis.
    PLoS One 2018 18;13(6):e0199281. Epub 2018 Jun 18.
    Department of Psychology, Northeastern University, Boston MA, United States of America.
    The main objective of this study was to investigate the associations between waist circumference, metabolic risk factors, and executive function in adolescents.

    Methods: The study was cross-sectional and included 558 adolescents (mean age 14.2 years). Read More

    The Role of Insulin-like Growth Factor (IGF) Axis in Early Diagnosis of Pancreatic Adenocarcinoma (PDAC).
    J Clin Gastroenterol 2018 Jun 16. Epub 2018 Jun 16.
    Department of Digestive Tract Diseases.
    New-onset diabetes mellitus (DM) is one of the first symptoms of pancreatic adenocarcinoma (PDAC). The frequency of endocrine disorders is estimated between 40% and 80% in patients with pancreatic cancer. DM is a risk factor for cancer development but it may also be a consequence of the tumor growth. Read More

    Saxagliptin Upregulates Nesfatin-1 Secretion and Ameliorates Insulin Resistance and Metabolic Profiles in Type 2 Diabetes Mellitus.
    Metab Syndr Relat Disord 2018 Jun 18. Epub 2018 Jun 18.
    4 Endocrinology and Metabolism Department, Qinhong Health Center , Nanjing, Jiangsu, China .
    Background And Aims: Saxagliptin as one of dipeptidyl peptidase-4 (DPP-4) inhibitors can effectively improve glycaemic control in type 2 diabetes mellitus, and nesfatin-1 is regarded as a very important factor in regulating feeding behavior and energy homeostasis. In this trial, we observed the effect of saxagliptin on regulating nesfatin-1 secretion and ameliorating insulin resistance and metabolic profiles in type 2 diabetes mellitus.

    Methods: One hundred two type 2 diabetes participants (M/F = 48/54) were investigated. Read More

    Glucocorticoid exposure causes disrupted glucoregulation, cardiac inflammation and elevated dipeptidyl peptidase-4 activity independent of glycogen synthase kinase-3 in female rats.
    Arch Physiol Biochem 2018 Jun 18:1-9. Epub 2018 Jun 18.
    a HOPE Cardiometabolic Research Team and Department of Physiology, College of Health Sciences , University of Ilorin , Ilorin , Nigeria.
    Objective: We tested the hypothesis that glucocorticoid (GC) exposure in female rats would lead to glucose dysregulation and elevated cardiac inflammatory biomarkers, which are dipeptidyl peptidase-4 (DPP-4)- and glycogen synthase kinase-3 (GSK-3)-dependent.

    Methods: Female Wistar rats received vehicle (control; n = 6) or GC (dexamethasone; n = 6; 0.2 mg/kg; p. Read More

    Reduction in Serum Triglyceride Levels in Diabetic Patients May Result in Decreased Insulin Dependence and Disease Regression.
    Isr Med Assoc J 2018 Jun;20(6):363-367
    Background: Type 2 diabetes mellitus is a multifactorial disease in which genetic susceptibility and environmental factors induce pancreatic β-cell dysfunction and insulin resistance. Additional factors such as hyperglycemia and hyperlipidemia have roles in β-cell dysfunction and disease progression. The phenomenon of lipid-induced pancreatic β-dysfunction, designated as lipotoxicity, has been observed in several in vitro and in vivo experiments; however, there is still no solid evidence for the occurrence of this event in humans. Read More

    Polycystic Ovary Syndrome and Periodontal disease: Underlying Links- A Review.
    Indian J Endocrinol Metab 2018 Mar-Apr;22(2):267-273
    Department of Periodontology, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India.
    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, which negatively affects various health systems. There is an extensive literature regarding the association of PCOS and other systemic conditions such as diabetes mellitus, cardiovascular disease, and psychological disorders. However, there is a lack of literature in associating PCOS and periodontal disease. Read More

    Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism.
    Open Vet J 2018 30;8(2):193-199. Epub 2018 May 30.
    Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Clínica Médica de Pequeños Animales y Hospital Escuela de Medicina Veterinaria, Unidad de Endocrinología, Av. Chorroarín 280, Buenos Aires CP 1427, Argentina.
    Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia, dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production and insulin resistance of the skeletal muscle and adipose tissue. The aim of this study was to evaluate the effects of metformin on the control of metabolic disorders of dogs with hyperadrenocorticism (HAC). Read More

    Does bariatric surgery influence plasma levels of fetuin-A and leukocyte cell-derived chemotaxin-2 in patients with type 2 diabetes mellitus?
    PeerJ 2018 12;6:e4884. Epub 2018 Jun 12.
    Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
    Background: Fetuin-A and leukocyte cell-derived chemotaxin-2 (LECT-2) are liver-derived proteins. Fetuin-A is an independent risk factor for type 2 diabetes (T2D) and obese patients with T2D have higher plasma fetuin-A levels than those without T2D. LECT-2 has positive correlation with the severity of both obesity and insulin resistance. Read More

    Use of Readily Accessible Inflammatory Markers to Predict Diabetic Kidney Disease.
    Front Endocrinol (Lausanne) 2018 22;9:225. Epub 2018 May 22.
    Endocrine Centre of Excellence, Austin Health, Melbourne, VIC, Australia.
    Diabetic kidney disease is a common complication of type 1 and type 2 diabetes and is the primary cause of end-stage renal disease in developed countries. Early detection of diabetic kidney disease will facilitate early intervention aimed at reducing the rate of progression to end-stage renal disease. Diabetic kidney disease has been traditionally classified based on the presence of albuminuria. Read More

    Overcoming endocrine resistance in hormone receptor-positive breast cancer.
    Curr Oncol 2018 Jun 13;25(Suppl 1):S18-S27. Epub 2018 Jun 13.
    Division of Hematology/Oncology, St. Michael's Hospital, University of Toronto, Toronto, ON.
    Endocrine therapy, a major modality in the treatment of hormone receptor (hr)-positive breast cancer (bca), has improved outcomes in metastatic and nonmetastatic disease. However, a limiting factor to the use of endocrine therapy in bca is resistance resulting from the development of escape pathways that promote the survival of cancer cells despite estrogen receptor (er)-targeted therapy. The resistance pathways involve extensive cross-talk between er and receptor tyrosine kinase growth factors [epidermal growth factor receptor, human epidermal growth factor receptor 2 (her2), and insulin-like growth factor 1 receptor] and their downstream signalling pathways-most notably pi3k/akt/mtor and mapk. Read More

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