Search our Database of Scientific Publications and Authors

I’m looking for a

    103964 results match your criteria Insulin Resistance

    1 OF 2080

    Comprehensive Study of Multiple Stages Progressing to Nonalcoholic Steatohepatitis with Subsequent Fibrosis in SD Rats.
    Int J Mol Sci 2017 Aug 18;18(8). Epub 2017 Aug 18.
    State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
    Because of the absence of the time course of histological nonalcoholic fatty hepatitis with subsequent fibrotic progression, the effective approaches available for controlling the onset and progression of non-alcoholic steatohepatitis (NASH) remain limited. Therefore, we detected the serum and liver tissue related lipid metabolism disorder, liver pathology and relative molecular makers alteration dynamically in a high fat-sucrose diet during different time points. High fat-sucrose diet significantly increased the serum lipid level on day 10. Read More

    Fibroblast growth factor-21 and omentin-1 hepatic mRNA expression and serum levels in morbidly obese women with non-alcoholic fatty liver disease.
    J Physiol Pharmacol 2017 Jun;68(3):363-374
    Chair and Department of Gastroenterology and Hepatology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
    Fibroblast growth factor-21 (FGF21) and omentin-1 have been recognized as potent antidiabetic agents with potential hepatoprotective activity. The aim of this study was to evaluate hepatic FGF21 and omentin-1 mRNA expression as well as their serum levels as predictive markers of liver injury and insulin resistance in morbidly obese women with non-alcoholic fatty liver disease (NAFLD). This study included 56 severely obese women who underwent intraoperative wedge liver biopsy during the bariatric surgery. Read More

    Diet quality and its implications on the cardio-metabolic, physical and general health of older men: the Concord Health and Ageing in Men Project (CHAMP).
    Br J Nutr 2017 Jul;118(2):130-143
    1School of Life and Environmental Sciences,Charles Perkins Centre,University of Sydney,Sydney,NSW, 2006,Australia.
    The revised Dietary Guideline Index (DGI-2013) scores individuals' diets according to their compliance with the Australian Dietary Guideline (ADG). This cross-sectional study assesses the diet quality of 794 community-dwelling men aged 74 years and older, living in Sydney, Australia participating in the Concord Health and Ageing in Men Project; it also examines sociodemographic and lifestyle factors associated with DGI-2013 scores; it studies associations between DGI-2103 scores and the following measures: homoeostasis model assessment - insulin resistance, LDL-cholesterol, HDL-cholesterol, TAG, blood pressure, waist:hip ratio, BMI, number of co-morbidities and medications and frailty status while also accounting for the effect of ethnicity in these relationships. Median DGI-2013 score was 93·7 (54·4, 121·2); most individuals failed to meet recommendations for vegetables, dairy products and alternatives, added sugar, unsaturated fat and SFA, fluid and discretionary foods. Read More

    Exploring the cardio-metabolic relevance of T-cadherin: A pleiotropic adiponectin receptor.
    Endocr Metab Immune Disord Drug Targets 2017 Aug 18. Epub 2017 Aug 18.
    St-Boniface Hospital Albrechtsen Research Centre - Canadian Centre for Agri-Food Research in Health and Medicine Winnipeg, Manitoba. Canada.
    Background And Objective: T cadherin is a unique member of the cadherin family and is primarily expressed in the cardiovascular system. T cadherin has not been abundantly studied, but the studies conducted to date have explored the impact of this protein on health and the function of organs involved in metabolic regulation.

    Methods: This article examines the recent knowledge of the ligand partners for T cadherin and the potential contribution(s) of T-cadherin to cardio-metabolic function. Read More

    Metformin - a new old drug.
    Endokrynol Pol 2017 ;68(4):482-496
    Department of Internal Medicine, Diabetology and Cardiometabolic Disorders, School of Medicine with the Division of Dentistry in Zabrze,Medical University of Silesia, Zabrze, Poland.
    For many years metformin has been the gold standard in the treatment of type 2 diabetes. According to recommendations of the most important diabetes associations, this is the first-choice drug for use as monotherapy in patients with newly diagnosed type 2 diabetes. Metformin is also recommended in combined treatment when monotherapy is no longer effective. Read More

    Addison's disease concomitant with corticotropin deficiency and pituitary CRH resistance - a case report.
    Endokrynol Pol 2017 ;68(4):468-471
    Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland, Poland; Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland, Poland.
    A 36-year-old woman was found to have a low morning ACTH concentration despite a history of Addison's disease. Past medical history: At the age of 23 years the subject developed Graves's disease, which was treated with radioiodine. At about the same time, she claimed to have two episodes of pancreatitis treated with cholecystectomy. Read More

    Regulation of hepatic Na(+)/K(+)-ATPase in obese female and male rats: involvement of ERK1/2, AMPK, and Rho/ROCK.
    Mol Cell Biochem 2017 Aug 17. Epub 2017 Aug 17.
    Laboratory of Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Sciences, University of Belgrade, Mike Petrovica Alasa 12-14, P.O.Box 522, 11000, Belgrade, Serbia.
    In this study, we assessed whether the disturbed regulation of sodium/potassium-adenosine-triphosphatase (Na(+)/K(+)-ATPase) occurs as a consequence of obesity-induced IR in sex-specific manner. We also assessed whether alterations of IRS/PI3K/Akt, ERK1/2, AMPKα, and RhoA/ROCK signaling cascades have an important role in this pathology. Female and male Wistar rats (150-200 g, 8 weeks old) were fed a standard laboratory diet or a high-fat (HF) diet (42% fat) for 10 weeks. Read More

    Melatonin, mitochondria, and the metabolic syndrome.
    Cell Mol Life Sci 2017 Aug 17. Epub 2017 Aug 17.
    BIOMED-UCA-CONICET and Department of Teaching and Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Av. Alicia Moreau de Justo 1500, 4o piso, 1107, Buenos Aires, Argentina.
    A number of risk factors for cardiovascular disease including hyperinsulinemia, glucose intolerance, dyslipidemia, obesity, and elevated blood pressure are collectively known as metabolic syndrome (MS). Since mitochondrial activity is modulated by the availability of energy in cells, the disruption of key regulators of metabolism in MS not only affects the activity of mitochondria but also their dynamics and turnover. Therefore, a link of MS with mitochondrial dysfunction has been suspected since long. Read More

    A syndromic extreme insulin resistance caused by biallelic POC1A mutations in exon 10.
    Eur J Endocrinol 2017 Aug 17. Epub 2017 Aug 17.
    A Brusco, Medical Sciences, University of Torino, Torino, 10126, Italy
    POC1A encodes a protein with a role in centriole assembly and stability, and in ciliogenesis. Biallelic loss of function mutations affecting POC1A cause SOFT syndrome, an ultra-rare condition characterized by short stature, onychodysplasia, facial dysmorphism and hypotrichosis. Using exome sequencing, we identified a homozygous frameshift mutation (c. Read More

    Acute oxygen sensing by the carotid body: from mitochondria to plasma membrane.
    J Appl Physiol (1985) 2017 Aug 17:jap.00398.2017. Epub 2017 Aug 17.
    University of California, San Francisco
    Maintaining oxygen homeostasis is crucial to the survival of animals. Mammals respond acutely to changes in blood oxygen levels by modulating cardiopulmonary function. The major sensor of blood oxygen that regulates breathing is the carotid body (CB), a small chemosensory organ located at the carotid bifurcation. Read More

    Relationship between sleep duration and childhood obesity: Systematic review including the potential underlying mechanisms.
    Nutr Metab Cardiovasc Dis 2017 Jul 25. Epub 2017 Jul 25.
    University of Pécs, Department of Paediatrics, Pécs, Hungary. Electronic address:
    Aim: The prevalence of obesity is continually increasing worldwide. Determining risk factors for obesity may facilitate effective preventive programs. The present review focuses on sleep duration as a potential risk factor for childhood obesity. Read More

    Inhibiting protein tyrosine phosphatase 1B to improve regenerative functions of endothelial cells.
    J Cardiovasc Pharmacol 2017 Aug 4. Epub 2017 Aug 4.
    1 Department of Physiology and Pathophysiology, School of Basic Medicine, Shandong University, Jinan, Shandong Province, China 2 Department of Emergency, Qilu hospital, Shandong University, Jinan, Shandong Province, China 3 The Key Laboratory of Cardiovascular Remodeling and Function Research (Chinese Ministry of Education and Chinese Ministry of Health) & The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.
    Protein tyrosine phosphatase-1B (PTP1B) is an important negative regulator of insulin receptor- and vascular endothelial growth factor receptor-dependent signalings in endothelial cells. Genetic or pharmacological inhibition of PTP1B has been shown to enhance endothelial cell proliferation and migration, and increase nitric oxide production. In vivo, inhibiting PTP1B can reverse endothelial dysfunction, promote angiogenesis, and accelerate wound healing. Read More

    Changes in Lipids and Inflammatory Markers after Consuming Diets High in Red Meat or Dairy for Four Weeks.
    Nutrients 2017 Aug 17;9(8). Epub 2017 Aug 17.
    Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia.
    There is a body of evidence linking inflammation, altered lipid metabolism, and insulin resistance. Our previous research found that insulin sensitivity decreased after a four-week diet high in dairy compared to a control diet and to one high in red meat. Our aim was to determine whether a relationship exists between changes in insulin sensitivity and inflammatory biomarkers, or with lipid species. Read More

    Treatment of Diabetic Ketoacidosis Associated With Antipsychotic Medication: Literature Review.
    J Clin Psychopharmacol 2017 Aug 15. Epub 2017 Aug 15.
    From the *Psychiatric Hospital Sveti Ivan; †Zagreb School of Medicine; ‡Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia; §Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Newham Centre for Mental Health, London, United Kingdom; and ∥Department of Psychiatry, University Hospital Centre Zagreb, Zagreb, Croatia.
    Background: The second-generation antipsychotics (SGAs) are associated with metabolic disturbances. Diabetic ketoacidosis (DKA) is a rare, but potentially fatal sign of acute glucose metabolism dysregulation, which may be associated with the use of SGAs. This study aims to review published reports of patients with schizophrenia and antipsychotic drug-associated DKA, focusing on the effective management of both conditions. Read More

    Nil Whey Protein Effect on Glycaemic Control after Intense Mixed-Mode Training in T2D.
    Med Sci Sports Exerc 2017 Aug 14. Epub 2017 Aug 14.
    1School of Sport and Exercise, Massey University Wellington, New Zealand; 2Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC; 3Department of Sport and Exercise, University of Winchester, Winchester, United Kingdom; 4Centre for Endocrine, Diabetes and Obesity Research, Wellington Regional Hospital, Wellington, New Zealand; 5Department of Medicine, University of Otago, Wellington, Wellington, New Zealand.
    While intense endurance and resistance exercise training and whey protein supplementation have both been shown to independently improve glycaemic control, no known studies have examined the effect of high-intensity mixed-mode interval training (MMIT) and whey supplementation in adults with Type-2 diabetes (T2D).

    Purpose: To determine if peri-training whey protein supplementation combined with MMIT can improve glycaemic control.

    Methods: In a double-blind randomised controlled trial, 24 men (55. Read More

    Role of Endoplasmic Reticulum-Mitochondria Communication in Type 2 Diabetes.
    Adv Exp Med Biol 2017 ;997:171-186
    Faculté de médecine Lyon-Sud, UMR INSERM U1060, CarMeN Laboratory, Lyon 1 University, INRA U1397, 165 chemin du grand Revoyet, BP12, F-69921, Oullins Cedex, France.
    Although mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and disrupted lipid and calcium (Ca(2+)) homeostasis are classically associated with both insulin resistance and β-cell dysfunction in type 2 diabetes mellitus (T2DM), the interplay between these metabolic stresses is less known. Both organelles interact through contact points known as mitochondria-associated membranes (MAM), in order to exchange both lipids and Ca(2+) and regulate cellular homeostasis. Recent evidences suggest that MAM could be an important hub for hormonal and nutrient signaling in the liver and that ER-mitochondria miscommunication could participate to hepatic insulin resistance, highlighting the importance of MAM in the control of glucose homeostasis. Read More

    Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies.
    Target Oncol 2017 Aug 16. Epub 2017 Aug 16.
    Boehringer Ingelheim RCV, Dr. Boehringer Gasse 5-11, 1121, Vienna, Austria.
    Despite a strong preclinical rationale for targeting the insulin-like growth factor (IGF) axis in cancer, clinical studies of IGF-1 receptor (IGF-1R)-targeted monotherapies have been largely disappointing, and any potential success has been limited by the lack of validated predictive biomarkers for patient enrichment. A large body of preclinical evidence suggests that the key role of the IGF axis in cancer is in driving treatment resistance, via general proliferative/survival mechanisms, interactions with other mitogenic signaling networks, and class-specific mechanisms such as DNA damage repair. Consequently, combining IGF-targeted agents with standard cytotoxic agents, other targeted agents, endocrine therapies, or immunotherapies represents an attractive therapeutic approach. Read More

    Spin Trapping: A Review for the Study of Obesity Related Oxidative Stress and Na(+)/K(+)-ATPase.
    J Clin Cell Immunol 2017 Jun 17;8(3). Epub 2017 May 17.
    Department of Surgery and Biomedical Sciences, Marshall University, USA.
    Reactive oxygen species (ROS) have gained attention with mounting evidence of their importance in cell signaling and various disease states. ROS is produced continuously as a natural by-product of normal oxygen metabolism. However, high levels ROS causes oxidative stress and damage to biomolecules. Read More

    Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition.
    Diabetol Metab Syndr 2017 15;9:62. Epub 2017 Aug 15.
    Department of Epidemiology, School of Public Health, University of Sao Paulo, Av. Dr. Arnaldo, 715, Sao Paulo, SP Zip code 01246-904 Brazil.
    Aims: To describe the abundance of major phyla and some genera in the gut microbiota of individuals according to dietary habits and examine their associations with inflammatory markers, insulin resistance, and cardiovascular risk profile.

    Methods: A total of 268 non-diabetic individuals were stratified into groups of dietary types (strict vegetarians, lacto-ovo-vegetarians, and omnivores). The taxonomic composition and phylogenetic structure of the microbiota were obtained through the analysis of the 16S rRNA gene. Read More

    Effects of a liquid high-fat meal on postprandial lipid metabolism in type 2 diabetic patients with abdominal obesity.
    Nutr Metab (Lond) 2017 14;14:54. Epub 2017 Aug 14.
    Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China.
    Background: Postprandial lipemia and lipoprotein lipase (LPL) activity play crucial roles in the pathogenesis of accelerated atherosclerosis. This study aimed to evaluate the postprandial lipid metabolism after the ingestion of a liquid high-fat meal in type 2 diabetic patients with abdominal obesity, and determine if the PvuII polymorphisms of LPL influence their postprandial lipid responses.

    Methods: Serum glucose, insulin, triglycerides (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were measured in fasting and postprandial state at 0. Read More

    Circulating zinc-α2-glycoprotein levels are low in newly diagnosed patients with metabolic syndrome and correlate with adiponectin.
    Nutr Metab (Lond) 2017 14;14:53. Epub 2017 Aug 14.
    Department of Endocrinology, the Affiliated Hospital, Zunyi Medical College, Guizhou, China.
    Background: Zinc-α2-glycoprotein (ZAG) is a novel adipokine that reduces insulin resistance, protecting against type 2 diabetes. However, past studies have been contradictory. This cross-sectional study aims to investigate the association of circulating ZAG with metabolic syndrome (MetS) in middle-aged and older Chinese adults. Read More

    Patients with Nonalcoholic Fatty Liver Disease Have a Low Response Rate to Vitamin D Supplementation.
    J Nutr 2017 Aug 16. Epub 2017 Aug 16.
    Department of Gastroenterology and Hepatology, Pathobiology, Cleveland Clinic, Cleveland, OH
    Background: Hypovitaminosis D is associated with an increased severity of nonalcoholic fatty liver disease (NAFLD), but reports on the response to cholecalciferol (vitamin D3) supplementation are conflicting.Objective: The objective of this study was to determine if standard vitamin D3 supplementation is effective in NAFLD with hypovitaminosis D.Methods: Sixty-five well-characterized adults [age (mean ± SD): 51. Read More

    Filling the void: a role for exercise induced BDNF and brain amyloid precursor protein processing.
    Am J Physiol Regul Integr Comp Physiol 2017 Aug 16:ajpregu.00255.2017. Epub 2017 Aug 16.
    Brock University
    Inactivity, obesity, and insulin resistance are significant risk factors for the development of Alzheimer's disease (AD). Several studies have demonstrated that diet induced obesity, inactivity, and insulin resistance exacerbates neuropathological hallmarks of AD. The aggregation of beta-amyloid peptides is one of these hallmarks. Read More


    Metabolic profile in two physically active Inuit groups consuming either a western or a traditional Inuit diet.
    Int J Circumpolar Health 2012 Jan;71(1):17342
    c Department of Biomedical Sciences, Center for Healthy Ageing , University of Copenhagen , Copenhagen , Denmark.
    Objectives: To evaluate the effect of regular physical activity on metabolic risk factors and blood pressure in Inuit with high BMI consuming a western diet (high amount of saturated fatty acids and carbohydrates with a high glycemic index).

    Study Design: Cross sectional study, comparing Inuit eating a western diet with Inuit eating a traditional diet.

    Methods: Two physically active Greenland Inuit groups consuming different diet, 20 eating a traditional diet (Qaanaaq) and 15 eating a western diet (TAB), age (mean (range)); 38, (22-58) yrs, BMI; 28 (20-40) were subjected to an oral glucose tolerance test (OGTT), blood sampling, maximal oxygen uptake test, food interview/collection and monitoring of physical activity. Read More

    Tumor characteristics in obese women with breast cancer.
    J Clin Oncol 2012 Sep;30(27_suppl):179
    New York University Cancer Institute, New York, NY.
    179 Background: Obesity is an established risk factor for postmenopausal breast cancer. Though women with high BMI tend to develop less aggressive molecular subtypes, previous studies have shown that they still have a higher risk of recurrence and worse prognosis. The biological mechanisms for this difference in outcome have yet to be identified. Read More

    Changes in plasma metabolomic profiles during the first 3 months of androgen-deprivation therapy for prostate cancer.
    J Clin Oncol 2012 Feb;30(5_suppl):116
    Massachusetts General Hospital, Boston, MA; Metabolon, Inc., Morrisville, NC; Massachusetts General Hospital Cancer Center, Boston, MA.
    116 Background: Androgen-deprivation therapy (ADT) with a GnRH agonist is the foundational systemic therapy for prostate cancer but causes gain of fat mass, loss of muscle mass, adverse changes in serum lipid profile, and a decline in insulin sensitivity. It is unknown whether ADT causes a broader pattern of metabolic alterations. In order to better characterize the metabolic effects of ADT, we measured changes in plasma metabolomic profile during the first 3 months of ADT. Read More

    Effect of sequential docetaxel followed by mTOR inhibitor temsirolimus on suppression of PI3K overactivation resistance mechanism.
    J Clin Oncol 2012 Oct;30(30_suppl):88
    University of Kansas Medical School, Kansas City, KS.
    88 Background: Mammalian target of rapamycin (mTOR) is a downstream regulatory protein of the PI3K/Akt signal transduction pathway. This is a common pathway for a several cell surface receptors including IGFR (Insulin-like Growth Factor Receptor) and EGFR (Epidermal Growth Factor Receptor). The activation of these receptors through PI3K/Akt pathway is essential in cell proliferation, angiogenesis, and anti-apoptosis process. Read More

    Modulation of insulin-like growth factors (IGF I-II) and IGF binding-protein 3 (IGFBP-3) through exercise training in women with breast cancer: A systematic review and meta-analysis.
    J Clin Oncol 2014 Sep;32(26_suppl):120
    Andalusian School of Public Health, University of Grenade, Grenade, Spain.
    120 Background: Epidemiological data suggest that Insulin-like growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) are associated with breast cancer risk, apoptosis and other carcinogenic mechanisms. This metaanalysis evaluates the effects of exercise interventions in controlling serum concentrations of Insulin-like growth factors (IGF1-IGF2) and IGFBP-3 in women with breast cancer.

    Methods: We incorporated the PRISMA statement. Read More

    A phase II study of linsitinib (OSI-906) in patients with asymptomatic or mildly symptomatic (non-opioid requiring) metastatic castrate resistant prostate cancer (CRPC).
    J Clin Oncol 2013 Feb;31(6_suppl):197
    Cleveland Clinic, Cleveland, OH.
    197 Background: Novel agents capable of blocking AR ligand independent pathways responsible for the development of CRPC are needed. IGF-1R and its ligands (IGF-1/IGF-2) play a key role in regulating growth, resistance to apoptosis, and invasion in PCa. IGF-1R is overexpressed in PCa and mediates resistance to ADT. Read More

    A Carbohydrate-Rich Beverage Prior to Surgery Prevents Surgery-Induced Immunodepression: A Randomized, Controlled, Clinical Trial.
    JPEN J Parenter Enteral Nutr 2006 ;30(1):21-26
    From the * Department of Nutrition Science and Dietetics and Nutritional Team, † Department of Surgical Oncology, ‡ Department of Pathology and Immunology, § Department of Anesthesiology, ∥ Department of Clinical Epidemiology and Biostatistics, ¶ Department of Intensive Care and Nutritional Team, and the # Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands.
    Background: Fasting before surgery is still common care in a lot of western hospitals. Overnight fasting can induce postoperative insulin resistance. Insulin resistance has been shown to be related to infectious morbidity. Read More

    The effect of aerobic exercise on the metabolic risk profile of breast cancer survivors 2-6 months post chemotherapy.
    J Clin Oncol 2011 Sep;29(27_suppl):244
    Trinity College Dublin, Dublin, Ireland; School of Medicine, Trinity College Dublin, Dublin, Ireland; Ireland Cooperative Oncology Research Group, Dublin, Ireland; Department of Surgery, St. James's Hospital, Dublin, Ireland.
    244 Background: Current literature suggests that weight gain during treatment for breast cancer is associated with a poorer prognosis and an increased risk of developing secondary health problems such as the metabolic syndrome (MetSyn). Physical activity (PA) can alter features of the MetSyn and improve body composition by reducing abdominal adiposity. We report metabolic results of a prospective randomized controlled trial (PEACH trial; Walsh JM, et al. Read More

    MEDI-573 as a novel approach to IGF-1R and IR-A signaling inhibition by blocking IGF ligands: Phase I PK/PD, safety data, and disease linkage studies in breast cancer.
    J Clin Oncol 2011 Sep;29(27_suppl):271
    Mayo Clinic, Rochester, MN; MedImmune, LLC, Gaithersburg, MD; Karmanos Cancer Institute, Detroit, MI; Mayo Clinic, Jacksonville, FL.
    271 Background: MEDI-573 is a dual-targeting human antibody that neutralizes IGF-I/-II ligands and inhibits IGF-1R and insulin receptor-A (IR-A) signaling pathways, which play a role in breast and other epithelial cancers. By sparing IR-B and its hybrid receptors, MEDI-573 is expected to achieve antitumor activity without perturbing glucose homeostasis.

    Methods: In a 3 + 3 dose-escalation trial ( NCT00816361 ), patients with advanced solid tumors, KPS ≥ 60, received MEDI-573 as a weekly 1-hr IV infusion at 0. Read More

    Consequences of gestational diabetes to the brain and behavior of the offspring.
    An Acad Bras Cienc 2017 Aug 14. Epub 2017 Aug 14.
    School of Pharmacy, Carlos Chagas Filho Street, 373, Building A, Underground, Room 024, Federal University of Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, Brazil.
    Gestational diabetes mellitus (GD) is a form of insulin resistance triggered during the second/third trimesters of pregnancy in previously normoglycemic women. It is currently estimated that 10% of all pregnancies in the United States show this condition. For many years, the transient nature of GD has led researchers and physicians to assume that long-term consequences were absent. Read More

    The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths.
    Curr Diab Rep 2017 Aug 15;17(10):87. Epub 2017 Aug 15.
    Department of Microbiology, Boston University School of Medicine, 72 East Concord Street L-516, Boston, MA, 02118, USA.
    Purpose Of Review: Adipose tissue (AT) houses both innate and adaptive immune systems that are crucial for preserving AT function and metabolic homeostasis. In this review, we summarize recent information regarding progression of obesity-associated AT inflammation and insulin resistance. We additionally consider alterations in AT distribution and the immune system in males vs. Read More

    Importance of adiponectin activity in the pathogenesis of Alzheimer's disease.
    Ann Clin Transl Neurol 2017 Aug 11;4(8):591-600. Epub 2017 Jul 11.
    Tokyo Metropolitan Institute of Medical Science2-1-6 KamikitazawaSetagaya-kuTokyo156-8506Japan.
    A recent study suggested that insulin resistance may play a central role in the pathogenesis of Alzheimer's disease (AD). In this regard, it is of note that upregulation of plasma adiponectin (APN), a benign adipokine that sensitizes the insulin receptor signaling pathway and suppresses inflammation, has recently been associated with the severities of amyloid deposits and cognitive deficits in the elderly, suggesting that APN may enhance the risk of AD. These results are unanticipated because AD has been linked to type II diabetes and other metabolic disorders in which hypoadiponectinemia has been firmly established, and because APN ameliorated neuropathological features in a mouse model of neurodegeneration. Read More

    Expanded Normal Weight Obesity and Insulin Resistance in US Adults of the National Health and Nutrition Examination Survey.
    J Diabetes Res 2017 25;2017:9502643. Epub 2017 Jul 25.
    Department of Exercise Sciences, College of Life Sciences, Brigham Young University, Provo, UT 84602, USA.
    This study aims to expand the evaluation of normal weight obesity (NWO) and its association with insulin resistance using an NHANES (1999-2006) sample of US adults. A cross-sectional study including 5983 men and women (50.8%) was conducted. Read More

    Effects of supervised structured aerobic exercise training program on fasting blood glucose level, plasma insulin level, glycemic control, and insulin resistance in type 2 diabetes mellitus.
    Pak J Med Sci 2017 May-Jun;33(3):576-580
    Syed Amir Gillani, Professor and Dean Faculty of Allied Health Sciences, University Institute of Physical Therapy, Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan.
    Objective: To determine the effects of supervised structured aerobic exercise training (SSAET) program on fasting blood glucose level (FBGL), plasma insulin level (PIL), glycemic control (GC), and insulin resistance (IR) in type 2 diabetes mellitus (T2DM).

    Methods: Riphah Rehabilitation and Research Centre (RRRC) was the clinical setting for this randomized controlled trial, located at Pakistan Railways General Hospital (PRGH), Rawalpindi, Pakistan. Study duration was 18 months from January 1, 2015 to June 30, 2016. Read More

    Clinical significance of glycemic parameters on venous thromboembolism risk prediction in gastrointestinal cancer.
    World J Gastroenterol 2017 Jul;23(28):5187-5195
    Fiorella Guadagni, David Della-Morte, Patrizia Ferroni, San Raffaele Roma Open University, 00166 Rome, Italy.
    Aim: To investigate the possible predictive role of routinely used glycemic parameters for a first venous thromboembolism (VTE) episode in gastrointestinal (GI) cancer ambulatory patients - with or without clinically diagnosed type 2 diabetes (T2D) or obesity - treated with chemotherapy.

    Methods: Pre-treatment fasting blood glucose, insulin, glycated hemoglobin (HbA1c) and homeostasis model of risk assessment (HOMA) were retrospectively evaluated in a cohort study of 342 GI cancer patients. Surgery was performed in 142 (42%) patients with primary cancer, 30 (21%) and 112 (79%) of whom received neoadjuvant and adjuvant therapies, respectively. Read More

    Effect of Tulsi (Ocimum sanctum Linn.) Supplementation on Metabolic Parameters and Liver Enzymes in Young Overweight and Obese Subjects.
    Indian J Clin Biochem 2017 Jul 16;32(3):357-363. Epub 2016 Sep 16.
    National Research Institute of Ayurved Drug Development, Bharatpur, Bhubaneswar, 751003 India.
    Ocimum sanctum Linn. (also known as Tulsi) is a sacred Indian plant, the beneficial role of which, in obesity and diabetes is described traditionally. This is a randomized, parallel group, open label pilot study to investigate the effect of O. Read More

    Biochemical Profile of Nonalcoholic Fatty Liver Disease Patients in Eastern India with Histopathological Correlation.
    Indian J Clin Biochem 2017 Jul 3;32(3):306-314. Epub 2016 Sep 3.
    Department of Gastroenterology, S.C.B. Medical College, Cuttack, Odisha 753007 India.
    Aminotransferase assay is often used as a screening test as well as an endpoint for resolution of disease in nonalcoholic fatty liver disease (NAFLD). Aim of the study was to evaluate the relationship of transaminase level with metabolic variables and histology in NAFLD. Single center observational study was conducted in a gastroenterology clinic at Cuttack in coastal Odisha. Read More

    iNKT cells prevent obesity-induced hepatic steatosis in mice in a C-C chemokine receptor 7-dependent manner.
    Int J Obes (Lond) 2017 Aug 16. Epub 2017 Aug 16.
    Department of Global Medical Science, Yonsei University Wonju College of Medicine, Wonju, Korea.
    Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are characterized by an increase in hepatic triglyceride content with infiltration of immune cells, which can cause steatohepatitis and hepatic insulin resistance. C-C chemokine receptor 7 (CCR7) is primarily expressed in immune cells, and CCR7 deficiency leads to the development of multi-organ autoimmunity, chronic renal disease, and autoimmune diabetes. Here, we investigated the effect of CCR7 on hepatic steatosis in a mouse model and its underlying mechanism. Read More

    The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes.
    Sci Rep 2017 Aug 15;7(1):8252. Epub 2017 Aug 15.
    PG Department of Biochemistry, Cell and Molecular Therapeutics Laboratory, Oriental Institute of Science and Technology, Midnapore, West Bengal, India.
    Diabetes is now epidemic worldwide. Several hundred-million peoples are presently suffering from this disease with other secondary-disorders. Stress, hypertension, sedentary life-style, carbohydrate/lipid metabolic-disorders due to genetic or environmental factors attributes to type-1 and/or type-2 diabetes. Read More

    Exercise training prevents skeletal muscle plasma membrane cholesterol accumulation, cortical actin filament loss, and insulin resistance in C57BL/6J mice fed a western-style high-fat diet.
    Physiol Rep 2017 Aug;5(16)
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana
    Insulin action and glucose disposal are enhanced by exercise, yet the mechanisms involved remain imperfectly understood. While the causes of skeletal muscle insulin resistance also remain poorly understood, new evidence suggest excess plasma membrane (PM) cholesterol may contribute by damaging the cortical filamentous actin (F-actin) structure essential for GLUT4 glucose transporter redistribution to the PM upon insulin stimulation. Here, we investigated whether PM cholesterol toxicity was mitigated by exercise. Read More

    Fasting insulin, insulin resistance and risk of cardiovascular or all-cause mortality in non-diabetic adults: a meta-analysis.
    Biosci Rep 2017 Aug 15. Epub 2017 Aug 15.
    Department of Cardiovascular Diseases, Jingmen Traditional Chinese Medical Hospital (Jingmen shihua hospital), Jingmen, China
    Studies on elevated fasting insulin or insulin resistance (IR) and cardiovascular or all-cause mortality risk in non-diabetic individuals have yielded conflicting results. This meta-analysis aimed to evaluate the association of elevated fasting insulin levels or insulin resistance as defined by homeostasis model assessment of insulin resistance (HOMA-IR) with cardiovascular or all-cause mortality in non-diabetic adults. We searched for relevant studies in PubMed and Emabse databases until November 2016. Read More

    Sleep Duration and Risk of Type 2 Diabetes.
    Pediatrics 2017 Aug 15. Epub 2017 Aug 15.
    Population Health Research Institute, St George's, University of London, London, United Kingdom; and.
    Background: Associations between sleep duration and type 2 diabetes (T2D) risk markers in childhood have been little studied. We examined associations between self-reported sleep duration and T2D risk markers in children.

    Methods: Cross-sectional study of 4525 multiethnic UK children aged 9 to 10 years. Read More

    Circulating Soluble RAGE Isoforms are Attenuated in Obese, Impaired Glucose Tolerant Individuals and are Associated with the Development of Type 2 Diabetes.
    Am J Physiol Endocrinol Metab 2017 Aug 15:ajpendo.00146.2017. Epub 2017 Aug 15.
    University of Illinois Chicago
    The soluble receptor for advanced glycation endproducts (sRAGE) may be protective against inflammation associated with obesity and type 2 diabetes (T2DM). The aim of this study was to determine the distribution of sRAGE isoforms, and whether sRAGE isoforms are associated with risk of T2DM development in subjects spanning the glucose tolerance continuum. In this retrospective analysis, circulating total sRAGE and endogenous secretory RAGE (esRAGE) were quantified via ELISA and cleaved RAGE (cRAGE) was calculated in 274 individuals stratified by glucose tolerance status (GTS) and obesity. Read More

    Hypoxia in Combination With Muscle Contraction Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle via the HIF-1α Pathway.
    Diabetes 2017 Aug 15. Epub 2017 Aug 15.
    Paul-Langerhans-Group for Integrative Physiology, German Diabetes Center (DDZ), Düsseldorf, Germany
    Skeletal muscle insulin resistance is the hallmark of type 2 diabetes, and develops long before the onset of the disease. It is well accepted that physical activity improves glycemic control but the knowledge on underlying mechanisms mediating the beneficial effects remains incomplete. Exercise is accompanied by a decrease in intramuscular oxygen levels resulting in induction of HIF-1α. Read More

    BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes.
    Int J Biol Macromol 2017 Aug 12. Epub 2017 Aug 12.
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China; The University of Chinese Academy of Sciences, Beijing, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China. Electronic address:
    Insulin resistance is a key feature of type 2 diabetes mellitus (T2DM) and is characterized by defects in insulin signaling. Protein tyrosine phosphatase 1B (PTP1B) is a major negative regulator of insulin signaling cascade and has attracted intensive investigation in recent T2DM therapy study. BPN, a marine-derived bromophenol compound, was isolated from the red alga Rhodomela confervoides. Read More

    1 OF 2080