Search our Database of Scientific Publications and Authors

I’m looking for a

    105151 results match your criteria Insulin Resistance

    1 OF 2104

    Glucocorticoid Signaling in Health and Disease: Insights from Tissue-Specific GR Knockout Mice.
    Endocrinology 2017 Oct 5. Epub 2017 Oct 5.
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
    Glucocorticoids are adrenally produced hormones critically involved in development, general physiology, and control of inflammation. Since their discovery, glucocorticoids have been widely utilized to treat a variety of inflammatory conditions. However, high doses or prolonged use leads to a number of side-effects throughout the body, which preclude their clinical utility. Read More

    Pharmacokinetics of IGF-I in PAPP-A2 Deficient Patients, Growth Response, and Effects on Glucose and Bone Density.
    J Clin Endocrinol Metab 2017 Sep 28. Epub 2017 Sep 28.
    Division of Endocrinology.
    Context: PAPP-A2 cleaves IGFBP-3 and -5 releasing free IGF-I. Homozygous mutations in PAPP-A2 result in growth failure with elevated total but low free IGF-I.

    Objective: To determine the 24-hour pharmacokinetic profile of free and total IGF-I after a dose of rhIGF-I. Read More

    Low Plasma Adiponectin Concentrations Predict Increases in Visceral Adiposity and Insulin Resistance.
    J Clin Endocrinol Metab 2017 Sep 28. Epub 2017 Sep 28.
    Department of Anthropology, University of Washington, Seattle, WA, USA.
    Context: Plasma adiponectin concentration has been shown to be inversely associated with body mass index (BMI) and insulin resistance in cross-sectional research. However, it is unclear whether adiponectin predicts future body composition and insulin resistance.

    Objective: To investigate the potential relationship between adiponectin concentration and future regional body fat distribution and insulin resistance. Read More

    Upregulation of IRS1 enhances IGF1 response in Y537S and D538G ESR1 mutant breast cancer cells.
    Endocrinology 2017 Sep 27. Epub 2017 Sep 27.
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh PA, USA.
    Increased evidence suggests that somatic mutations in the ligand binding domain of estrogen receptor (ERα/ESR1) are critical mediators of endocrine-resistant breast cancer progression. Insulin-like growth factor-1 (IGF1) is an essential regulator of breast development and tumorigenesis, and also has a role in endocrine resistance. A recent study showed enhanced crosstalk between IGF1 and ERα in ESR1 mutant cells, but detailed mechanisms are incompletely understood. Read More

    Decreased homocysteine trans-sulfuration in hypertension with hyperhomocysteinemia: relationship with insulin resistance.
    J Clin Endocrinol Metab 2017 Sep 29. Epub 2017 Sep 29.
    Dept. of Medicine, Division of Metabolic Diseases, University of Padova, Italy.
    Context: Homocysteine is an independent cardiovascular risk factor and is increased in essential hypertension. Insulin stimulates homocysteine catabolism in healthy individuals. However, the mechanisms of hyperhomocysteinemia and its relationship with insulin resistance in essential hypertension are unknown. Read More

    Functional characterization of microRNA-27a-3p expression in human polycystic ovary syndrome.
    Endocrinology 2017 Sep 29. Epub 2017 Sep 29.
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
    The goal of this study was to characterize the function of microRNA-27a-3p (miR-27a-3p) in polycystic ovary syndrome (PCOS). MiR-27a-3p expression was analyzed in excised granulosa cells (GCs) from 21 PCOS and 12 normal patients undergoing IVF cycle treatments, and in 17 non-treated cuneiform ovarian resection PCOS samples and 13 control ovarian samples-from non-PCOS patients. We found that the expression of miR-27a-3p was significantly increased in both excised GCs and the ovaries of PCOS patients compared to the controls. Read More

    Serum quantitative proteomic analysis reveals soluble EGFR to be a marker of insulin resistance in male mice and humans.
    Endocrinology 2017 Oct 5. Epub 2017 Oct 5.
    Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama-City University, Yokohama 236-0004, Japan.
    To identify circulating factors as candidates involved in type 2 diabetes (T2DM), we conducted two different quantitative proteomic analyses: 1) db/db mouse sera were compared with db/+ mouse sera obtained at 4, 8, 12, and 24 weeks of age, and 2) db/db mouse sera from animals treated with liraglutide were compared with sera from animals without liraglutide treatment. 20 and eight proteins were differentially expressed in db/db mouse sera in the first experiment and in db/db mouse sera after liraglutide treatment in the second experiment, respectively. Soluble epidermal growth factor receptor (sEGFR) was identified as a common factor, and its protein level was significantly affected in both experiments. Read More

    Short-term vitamin E treatment impairs reactive oxygen species signaling required for adipose tissue expansion, resulting in fatty liver and insulin resistance in obese mice.
    PLoS One 2017 13;12(10):e0186579. Epub 2017 Oct 13.
    Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain.
    Objectives: The use of antioxidant therapy in the treatment of oxidative stress-related diseases such as cardiovascular disease, diabetes or obesity remains controversial. Our aim is to demonstrate that antioxidant supplementation may promote negative effects if used before the establishment of oxidative stress due to a reduced ROS generation under physiological levels, in a mice model of obesity.

    Methods: C57BL/6J mice were fed with a high-fat diet for 14 weeks, with (OE group) or without (O group) vitamin E supplementation. Read More

    Role of RBP2-Induced ER and IGF1R-ErbB Signaling in Tamoxifen Resistance in Breast Cancer.
    J Natl Cancer Inst 2018 Apr;110(4)
    Department of Pathology, College of Medicine, Hanyang University, Seoul, Republic of Korea; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea; Institute for Bioengineering and Biopharmaceutical Research (IBBR), Hanyang University, Seoul, Republic of Korea.
    Background: Despite the benefit of endocrine therapy, acquired resistance during or after treatment still remains a major challenge in estrogen receptor (ER)-positive breast cancer. We investigated the potential role of histone demethylase retinoblastoma-binding protein 2 (RBP2) in endocrine therapy resistance of breast cancer.

    Methods: Survival of breast cancer patients according to RBP2 expression was analyzed in three different breast cancer cohorts including METABRIC (n = 1980) and KM plotter (n = 1764). Read More

    An Information Theoretical Analysis of Human Insulin-Glucose System Towards The Internet of Bio-Nano Things.
    IEEE Trans Nanobioscience 2017 Oct 11. Epub 2017 Oct 11.
    Molecular communication is an important tool to understand biological communications with many promising applications in Internet of Bio-Nano Things (IoBNT). The insulinglucose system is of key significance among the major intrabody nanonetworks since it fulfills metabolic requirements of the body. Study of biological networks from information and communication theoretical (ICT) perspective is necessary for their introduction in the IoBNT framework. Read More

    [Research progress on therapeutic targets of active components in Chinese herbs for treatment of nonalcoholic fatty liver disease].
    Zhongguo Zhong Yao Za Zhi 2017 Mar;42(6):1109-1112
    The Key Lab of Metabolic Disease in Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
    Nonalcoholic fatty liver disease(NAFLD) is a kind of metabolic liver injury, which is closely associated with insulin resistance and genetic susceptibility. Traditional Chinese herbs used in the treatment of nonalcoholic fatty liver disease are widely investigated in recent years. A series of recent studies show that the effects of the active components in traditional Chinese herbs on NAFLD are associated with activating AMPK signaling pathway, improving insulin resistance, modulating the activity and expression of peroxisome proliferator-activated receptor γ, antioxidant and anti-inflammatory activities and regulating intestinal flora. Read More

    Increased maternal insulin resistance promotes placental growth and decreases placental efficiency in pregnancies with obesity and gestational diabetes mellitus.
    J Obstet Gynaecol Res 2017 Oct 13. Epub 2017 Oct 13.
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Tokyo, Japan.
    Aim: Homeostasis model assessment for insulin resistance (HOMA-IR) was measured during pregnancy to analyze placental weight and efficiency in relation to maternal insulin resistance.

    Methods: A retrospective study of 510 pregnant women (130 with gestational diabetes mellitus [GDM], 380 with normal glucose tolerance) was conducted. We reviewed the patients' demographic data (age, parity, pre-pregnancy body mass index [BMI]) and perinatal outcomes (birth weight, placental weight, BMI at delivery, maternal weight gain, HOMA-IR). Read More

    Oligonol promotes glucose uptake by modulating the insulin signaling pathway in insulin-resistant HepG2 cells via inhibiting protein tyrosine phosphatase 1B.
    Arch Pharm Res 2017 Oct 12. Epub 2017 Oct 12.
    Department of Food and Life Science, Pukyong National University, Busan, 608-737, Republic of Korea.
    Insulin resistance and protein tyrosine phosphatase 1B (PTP1B) overexpression are strongly associated with type 2 diabetes mellitus (T2DM), which is characterized by defects in insulin signaling and glucose intolerance. In a previous study, we demonstrated oligonol inhibits PTP1B and α-glucosidase related to T2DM. In this study, we examined the molecular mechanisms underlying the anti-diabetic effects of oligonol in insulin-resistant HepG2 cells. Read More

    Increased hepatic fatty acid polyunsaturation precedes ectopic lipid deposition in the liver in adaptation to high-fat diets in mice.
    MAGMA 2017 Oct 12. Epub 2017 Oct 12.
    Laboratory for Functional and Metabolic Imaging, Swiss Federal Institute of Technology, Bâtiment CH, Station 6, 1015, Lausanne, Switzerland.
    Objective: We monitored hepatic lipid content (HLC) and fatty acid (FA) composition in the context of enhanced lipid handling induced by a metabolic high-fat diet (HFD) challenge and fasting.

    Materials And Methods: Mice received a control diet (10% of kilocalories from fat, N = 14) or an HFD (45% or 60% of kilocalories from fat, N = 10 and N = 16, respectively) for 26 weeks. A subset of five mice receiving an HFD (60% of kilocalories from fat) were switched to the control diet for the final 7 weeks. Read More

    The effect of cardamom supplementation on serum lipids, glycemic indices and blood pressure in overweight and obese pre-diabetic women: a randomized controlled trial.
    J Diabetes Metab Disord 2017 29;16:40. Epub 2017 Sep 29.
    Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Hojatdost street, Naderi street, Keshavarz Blv, Tehran, Iran.
    Background: Spice consumption helps the treatment of diseases due to their antioxidant and anti-inflammatory contents. Cardamom is one of this spices; therefore, this study is designed to determine the effect of cardamom supplementation on serum lipids, glycemic indices, and blood pressure in pre-diabetic women.

    Methods: Eighty overweight or obese pre-diabetic women were randomly allocated to two groups. Read More

    Correlation of Vitamin D with metabolic parameters in polycystic ovarian syndrome.
    J Family Med Prim Care 2017 Jan-Mar;6(1):115-119
    Department of Endocrinology, Army Hospital (R&R), New Delhi, India.
    Background: Polycystic ovarian syndrome (PCOS) and hypovitaminosis D are the two most common endocrine disorders in young women leading to many adverse metabolic consequences. We evaluated the correlation of 25-hydroxy Vitamin D (25OHD) with metabolic parameters and insulin resistance in PCOS.

    Materials And Methods: We included 100 PCOS patients (age 18-40 years, duration >6 months) serially, in this cross-sectional study. Read More

    Acanthosis nigricans: A screening test for insulin resistance - An important risk factor for diabetes mellitus type-2.
    J Family Med Prim Care 2017 Jan-Mar;6(1):43-46
    Department of Family Medicine, Aster MIMS Hospital, Kozhikode, Kerala, India.
    Background: Acanthosis nigricans (AN) is one of the signs suggestive of high insulin resistance (IR). IR is one of the mechanisms involved in pathogenesis of diabetes mellitus type-2 (DM Type-2). Thus, early detection of IR in children may allow us time to intervene well before the development of DM Type-2. Read More

    DNA methylation links genetics, fetal environment, and an unhealthy lifestyle to the development of type 2 diabetes.
    Clin Epigenetics 2017 3;9:105. Epub 2017 Oct 3.
    Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre, Scania University Hospital, Jan Waldenströms gata 35, 205 02 Malmö, Sweden.
    Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene transcription and, consequently, organ function. Genome-wide studies have shown altered DNA methylation in tissues important for glucose homeostasis including pancreas, liver, skeletal muscle, and adipose tissue from subjects with type 2 diabetes compared with nondiabetic controls. Read More

    Healthy eating index and cardiovascular risk factors among Iranian elderly individuals.
    ARYA Atheroscler 2017 Mar;13(2):56-65
    Professor, Food Security Research Center AND Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan AND Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute AND Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences Tehran, Iran.
    Background: Concurrent with increase in life expectancy, the prevalence of chronic diseases such as cardiovascular diseases (CVD) has also increased. Therefore, the aim of this study was to evaluate the association between healthy eating index (HEI) score and CVD risk factors among Iranian elderly.

    Methods: This cross-sectional study was performed on a sample of elderly persons from Isfahan, Iran, in 2013. Read More

    Camel Milk Has Beneficial Effects on Diabetes Mellitus: A Systematic Review.
    Int J Endocrinol Metab 2017 Apr 11;15(2):e42150. Epub 2017 Mar 11.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
    Context: Controlling diabetes, a worldwide metabolic disease, by effective alternative treatments is currently a topic of great interest. Camel milk is believed to be a suitable hypoglycemic agent in experimental animals and patients with diabetes. The current systematic review aimed at evaluating the effect of camel milk on diabetes. Read More

    Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity.
    Int J Obes (Lond) 2017 Oct 13. Epub 2017 Oct 13.
    St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, New South Wales, Australia.
    Objectives: To test the potential efficacy of recombinant macrophage inhibitory cytokine-1 (MIC-1/GDF15) as an obesity therapeutic.

    Methods: Male C57BL/6J mice, either fed on normal-chow or high-fat-diet for 16 weeks in order to induce diet-induced obesity, were infused with either recombinant MIC-1/GDF15 or vehicle for 34 days by osmotic-mini-pump. During the experimental period metabolic parameters were measured. Read More

    The melatonin receptor agonist piromelatine ameliorates impaired glucose metabolism in chronically stressed rats fed a high-fat diet.
    J Pharmacol Exp Ther 2017 Oct 12. Epub 2017 Oct 12.
    Lanzhou General Hospital of PLA.
    Modern lifestyle factors (high-caloric food rich in fat) and daily chronic stress are important risk factors for metabolic disturbances. Increased hypothalamic-pituitary-adrenal (HPA) axis activity and the subsequent excess production of glucocorticoids (GCs) in response to chronic stress (CS) leads to increases in metabolic complications, such as type 2 diabetes and insulin resistance (IR). Melatonin (MLT), which protects several regulatory components of the HPA axis from GC-induced deterioration, might improve glucose homeostasis. Read More

    A Drosophila model of insulin resistance associated with the human Trib3 Q/R polymorphism.
    Dis Model Mech 2017 Oct 12. Epub 2017 Oct 12.
    Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO 64110, USA
    Members of the Tribbles family of proteins are conserved pseudokinases with diverse roles in cell growth and proliferation. Both Drosophila Tribbles (Trbl) and vertebrate Trib3 proteins bind to Akt kinase to block its phosphorylation-activation and reduce downstream insulin-stimulated anabolism. A single nucleotide polymorphism (SNP) variant in human Trib3, which results in a glutamine (Q) to arginine (R) missense mutation in a conserved motif at position 84, confers stronger Akt binding resulting in reduced Akt phosphorylation and is associated with a predisposition to Type II diabetes, cardiovascular disease, diabetic nephropathy, chronic kidney disease and leukemogenesis. Read More

    Withania somnifera as a potential candidate to ameliorate high fat diet-induced anxiety and neuroinflammation.
    J Neuroinflammation 2017 Oct 12;14(1):201. Epub 2017 Oct 12.
    Department of Biotechnology, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
    Background: The epidemic of obesity has reached alarming levels in both developing and developed nations. Excessive calorie intake and sedentary lifestyle due to technological advancements are the main causal factors for overweight and obesity among the human population. Obesity has been associated with a number of co-morbidities such as hypertension, type 2 diabetes mellitus, cardiovascular diseases, and neurodegeneration and dementia. Read More

    Insulin resistance and bone age advancement in girls with central precocious puberty.
    Ann Pediatr Endocrinol Metab 2017 Sep 28;22(3):176-182. Epub 2017 Sep 28.
    Sowha Children's Hospital, Seoul, Korea.
    Purpose: Precocious puberty has significantly increased recently. While obesity is associated with puberty timing, the relationship between obesity and central precocious puberty (CPP) remains controversial. The purpose of this study was to determine whether insulin resistance is associated with bone age (BA) advancement in girls with CPP. Read More

    The triglyceride-to-high density lipoprotein cholesterol ratio in overweight Korean children and adolescents.
    Ann Pediatr Endocrinol Metab 2017 Sep 28;22(3):158-163. Epub 2017 Sep 28.
    Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
    Purpose: The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio has recently been reported as a biomarker of cardiometabolic risk in obese children and adolescents. The purpose of this study is to describe the TG/HDL-C ratio and related factors in overweight and normal weight Korean children and to evaluate whether the high TG/HDL-C ratio is associated with insulin resistance in overweight children and adolescents.

    Methods: Data from 255 overweight (aged 8. Read More

    Effects of growth hormone on glucose metabolism and insulin resistance in human.
    Ann Pediatr Endocrinol Metab 2017 Sep 28;22(3):145-152. Epub 2017 Sep 28.
    Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
    Growth hormone (GH) is important for promotion of somatic growth and the regulation of substrate metabolism. Metabolic action of GH occurs in multiple tissues including the liver, muscle, fat and pancreas either directly or indirectly through insulin-like growth factor 1. The diabetogenic action of GH has been well-described in previous in vivo studies. Read More

    Exposure to perchlorate, nitrate and thiocyanate, and prevalence of diabetes mellitus.
    Int J Epidemiol 2017 Sep 11. Epub 2017 Sep 11.
    Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
    Background: It is known that perchlorate, nitrate and thiocyanate have the property of inhibiting sodium iodide symporter. Animal studies have suggested that these compounds, especially perchlorate, might also interfere with insulin secretion. However, the association between their exposure and diabetes risk is largely unknown in humans. Read More

    Decreased insulin secretion in pregnant rats fed a low protein diet.
    Biol Reprod 2017 Aug 28. Epub 2017 Aug 28.
    Department of Obstetrics & Gynecology.
    Low protein (LP) diet during pregnancy leads to reduced plasma insulin levels in rodents, but the underlying mechanisms remain unclear. Glucose is the primary insulin secretagogue and enhanced glucose stimulated insulin secretion (GSIS) in beta cells contributes to compensation for insulin resistance and maintenance of glucose homeostasis during pregnancy. In this study we hypothesized that plasma insulin levels in pregnant rats fed LP diet is reduced due to disrupted GSIS of pancreatic islets. Read More

    The Relationship between Vitamin D and Type 2 Diabetes Is Intriguing: Glimpses from the Spect-China Study.
    Ann Nutr Metab 2017 Oct 13;71(3-4):195-202. Epub 2017 Oct 13.
    Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
    Objective: Vitamin D is a multifunctional vitamin for our body. Type 2 diabetes mellitus (T2DM) is a common metabolic disease. Whether T2DM affects the serum 25(OH)D level has not been reported. Read More

    Mangiferin ameliorates fatty liver via modulation of autophagy and inflammation in high-fat-diet induced mice.
    Biomed Pharmacother 2017 Oct 9;96:328-335. Epub 2017 Oct 9.
    Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China. Electronic address:
    Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease globally. The progression of NAFLD is complex and associated with inflammation, oxidative stress, autophagy, endoplasmic reticulum stress, and insulin resistance. Mangiferin, a natural C-glucosyl xanthone, has been reported to show multiple biological activities. Read More

    Polycystic Ovarian Syndrome (PCOS): long-term metabolic consequences.
    Metabolism 2017 Oct 9. Epub 2017 Oct 9.
    Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center School of Medicine, Amarillo, Texas, USA.
    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during their reproductive ages, associated with a plethora of cardiometabolic consequences, with obesity, insulin resistance and hyperandrogenemia playing a major role in the degree of such manifestations. These consequences include increased risk of glucose intolerance and diabetes mellitus (both type 2 and gestational), atherogenic dyslipidemia, systemic inflammation, non-alcoholic fatty liver disease, hypertension and coagulation disorders. Whether this cluster of metabolic abnormalities is also translated in increased cardiovascular disease (CVD) morbidity and mortality in later life, remains to be established. Read More

    Obesity as a risk factor for Alzheimer's disease: weighing the evidence.
    Obes Rev 2017 Oct 10. Epub 2017 Oct 10.
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
    Alzheimer's disease (AD) is the sixth leading cause of death in the USA today; therefore, it is imperative that public health initiatives and clinical strategies are developed to prevent and effectively treat AD. Despite the enormous impact that AD has on individuals, families, society, and the health care system, there are no biomarkers to clearly identify those at risk for AD, public health prevention strategies in place, or treatments to address the underlying pathology or stop the progression of AD. There is ample scientific as well as empirical evidence that obesity and its metabolic and vascular comorbidities are related to AD and likely in the causative pathway. Read More

    Genetic variants and traits related to insulin-like growth factor-I and insulin resistance and their interaction with lifestyles on postmenopausal colorectal cancer risk.
    PLoS One 2017 12;12(10):e0186296. Epub 2017 Oct 12.
    Division of General Internal Medicine, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America.
    Genetic variants and traits in metabolic signaling pathways may interact with lifestyle factors such as obesity, physical activity, and exogenous estrogen (E), influencing postmenopausal colorectal cancer (CRC) risk, but these interrelated pathways are not fully understood. In this case-cohort study, we examined 33 single-nucleotide polymorphisms (SNPs) in genes related to insulin-like growth factor-I (IGF-I)/ insulin resistance (IR) traits and signaling pathways, using data from 704 postmenopausal women in Women's Health Initiative Observation ancillary studies. Stratifying by the lifestyle modifiers, we assessed the effects of IGF-I/IR traits (fasting total and free IGF-I, IGF binding protein-3, insulin, glucose, and homeostatic model assessment-insulin resistance) on CRC risk as a mediator or influencing factor. Read More

    Dietary Anthocyanins and Insulin Resistance: When Food Becomes a Medicine.
    Nutrients 2017 Oct 12;9(10). Epub 2017 Oct 12.
    Pharmacognosy Research Laboratories & Herbal Analysis Services UK, University of Greenwich, Central Avenue, Charham-Maritime, Kent ME4 4TB, UK.
    Insulin resistance is an abnormal physiological state that occurs when insulin from pancreatic β-cells is unable to trigger a signal transduction pathway in target organs such as the liver, muscles and adipose tissues. The loss of insulin sensitivity is generally associated with persistent hyperglycemia (diabetes), hyperinsulinemia, fatty acids and/or lipid dysregulation which are often prevalent under obesity conditions. Hence, insulin sensitizers are one class of drugs currently employed to treat diabetes and associated metabolic disorders. Read More

    Combination of β-glucan and Morus alba L. Leaf Extract Promotes Metabolic Benefits in Mice Fed a High-Fat Diet.
    Nutrients 2017 Oct 12;9(10). Epub 2017 Oct 12.
    Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
    β-glucan (BG) and mulberry have received increasing attention for their benefits as natural sources of metabolic health. In the current study, we investigated the synergetic beneficial effects of BG and mulberry leaf extract (MLE) in mice fed a high-fat diet (HFD). Male C57BL6 mice were fed a HFD for twelve weeks to induce significant obesity and insulin resistance. Read More

    Influence of Grand Multiparity on the Levels of Insulin, Glucose and HOMA-IR in Comparison with Nulliparity and Primiparity.
    Pak J Biol Sci 2017 ;20(1):42-46
    Department of Clinical Biochemistry, College of Applied Medical Sciences, Shaqra University, Saudi Arabia.
    Objective: It is to compare the levels of fasting glucose and insulin as well as insulin resistance in grand multiparas with primiparity and nulliparity.

    Methodology: Fasting blood samples were collected from 100 non-pregnant ladies as control group, 100 primiparity pregnant women and 100 grand multiparity pregnant women. Glucose (FBS) and insulin (FSI) concentrations were measured by Hitachi 912 full automated Chemistry Analyzer (Roche Diagnostics, Germany) as manufacturer procedure. Read More

    Freeze-dried strawberry and blueberry attenuates diet-induced obesity and insulin resistance in rats by inhibiting adipogenesis and lipogenesis.
    Food Funct 2017 Oct 12. Epub 2017 Oct 12.
    Centre for Nutrition Research, University of Navarra, Spain.
    Obesity and type 2-diabetes are becoming a worldwide health problem, reiterating the importance of alternative therapies to tackle their progression. Here, we hypothesized that supplementation of diet with 6% w/w of a freeze-dried strawberry-blueberry (5 : 1) powder (FDSB) could exert beneficial metabolic effects on Wistar rats. FDSB-supplemented animals experienced significantly reduced body weight gain, food efficiency and visceral adiposity accumulation in two independent experiments. Read More

    Nuclear Magnetic Resonance-Assisted Metabolic Analysis of Plasma for Mild Gestational Diabetes Mellitus Patients.
    Metab Syndr Relat Disord 2017 Oct 12. Epub 2017 Oct 12.
    1 Department of Obstetrics, The First Affiliated Hospital of Nanjing Medical University , Nanjing, China .
    Aims: This study aimed at detecting the difference of metabolic profile in mild gestational diabetes mellitus (GDM) patients, and at identifying the correlation between the disturbed metabolites and insulin resistance pathway induced by the inflammation factors secreted by the placenta and adipocytes.

    Materials And Methods: Blood samples were collected from 36 pregnant women diagnosed with mild GDM and 36 normal glucose-tolerant (NGT) pregnant women. Metabolic profiles were acquired by using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy, and the data were analyzed by multivariate statistical data analysis. Read More

    Effect of Food on the Pharmacokinetics of Saroglitazar Magnesium, a Novel Dual PPARαγ Agonist, in Healthy Adult Subjects.
    Clin Drug Investig 2017 Oct 11. Epub 2017 Oct 11.
    Zydus Research Center, Survey No. 396/403, Sarkhej-Bavla, N.H. No. 8A, Moraiya, Ahmedabad, Gujarat, 382213, India.
    Background And Objective: Peroxisome proliferator-activated receptors (PPARs) have recently become a focus of interest for their important roles in glucose and lipid metabolism. In humans, PPARα activation causes a decrease in plasma triglyceride (TG) levels, enhancement of high-density lipoprotein cholesterol (HDL-C) and simultaneous enhancement of very-low-density lipoprotein (VLDL) lipolysis, whereas PPARγ agonists act as insulin sensitizers and improve insulin resistance, which is very useful in patients with type 2 diabetes mellitus (T2DM). Saroglitazar magnesium is a dual PPAR agonist with potent predominant PPARα and moderate PPARγ activity and the first glitazar to be granted marketing authorization in India. Read More

    Glycated albumin (GA) and inflammation: role of GA as a potential marker of inflammation.
    Inflamm Res 2017 Oct 11. Epub 2017 Oct 11.
    Epinex Diagnostics, Inc., 14351 Myford Road, Unit J, Tustin, CA, 92780, USA.
    Aims: Abnormal levels of glycated albumin (GA) are associated with the onset of both diabetes and inflammation. Although inflammation has long been associated with diabetes, this article aims to explore the underlying mechanisms of this relationship as it pertains to the role of GA.

    Methods: We have reviewed 52 research articles since the year 2000. Read More

    Endurance exercise training decreased serum levels of surfactant protein D and improved aerobic fitness of obese women with type-2 diabetes.
    Diabetol Metab Syndr 2017 25;9:74. Epub 2017 Sep 25.
    Graduation Program of Physical Education, Faculty of Physical Education, Federal University of Mato Grosso, Cuiabá, Brazil.
    Background: Surfactant protein D (SP-D) is a member of the collectin family and is an important component of the pulmonary innate host defense. To find the relationship between exercise training and SP-D in diabetes, we examined the possible effects of a 10-week endurance exercise-training program on serum levels of SP-D, leptin, lipid profile and insulin resistance in obese women with type-2 diabetes mellitus (T2DM).

    Methods: Twenty-two obese women with T2DM were randomly assigned to either exercise training (ET) or control (C) group. Read More

    Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes.
    Front Endocrinol (Lausanne) 2017 27;8:239. Epub 2017 Sep 27.
    Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane, QLD, Australia.
    Obesity is an important public health issue worldwide, where it is commonly associated with the development of metabolic disorders, especially insulin resistance (IR). Maternal obesity is associated with an increased risk of pregnancy complications, especially gestational diabetes mellitus (GDM). Metabolism is a vital process for energy production and the maintenance of essential cellular functions. Read More

    New Evidence against Chromium as an Essential Trace Element.
    J Nutr 2017 Oct 11. Epub 2017 Oct 11.
    Department of Chemistry, The University of Alabama, Tuscaloosa, AL
    Nearly 60 y ago, chromium, as the trivalent ion, was proposed to be an essential element, but the results of new studies indicate that chromium currently can only be considered pharmacologically active and not an essential element. Regardless, articles still continue to appear in the literature claiming chromium is an essential element. Chromium has been marketed as an agent to reduce body mass and develop muscle; however, such marketing claims are no longer allowed in the United States because these claims, similar to claims of essential status, are not supported by experiments. Read More

    Combined Salt and Caloric Restrictions: Potential Adverse Outcomes.
    J Am Heart Assoc 2017 Oct 11;6(10). Epub 2017 Oct 11.
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA
    Background: We hypothesized that caloric restriction (CR) and salt restriction (ResS) would have similar effects on reducing cardiovascular risk markers and that combining CR and ResS would be synergistic in modulating these markers.

    Methods And Results: To test our hypothesis, rats were randomized into 2 groups: ad libitum liberal salt diet (ad libitum/high-sodium, 1.6% sodium) or ResS diet (ad libitum/ResS, 0. Read More

    Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway.
    Daru 2017 Oct 11;25(1):21. Epub 2017 Oct 11.
    Department of Endocrine, Traditional Chinese Medicine Hospital of Shenzhen, Shenzhen, Guangdong, 518033, China.
    Background: Heqi San, a traditional Chinese medicine (TCM) has been reported to regulate hormone levels in patients with metabolic disease, suggesting a potential clinical application. In the current study, we aimed to elucidate the effect of Heqi San on rat model of polycystic ovary syndrome (PCOS).

    Method: PCOS model was established in female SD rats. Read More

    Does replacing sedentary behaviour with light or moderate to vigorous physical activity modulate inflammatory status in adults?
    Int J Behav Nutr Phys Act 2017 Oct 11;14(1):138. Epub 2017 Oct 11.
    HRB Centre for Diet and Health Research, School of Public Health, Western Gateway Building, University College Cork, Cork, Ireland.
    Background: Sedentary behaviour, obesity and insulin resistance are associated with pro-inflammatory status. Limited data on whether physical activity modulates inflammatory status and counteracts obesity and insulin resistance associated low-grade inflammation exist. Our objective was to investigate associations between objectively measured physical activity and inflammatory status, and specifically whether substituting daily sedentary behaviour with light activity or moderate to vigorous physical activity (MVPA), is associated with beneficial alterations to the inflammatory profile among middle-aged adults and those at increased cardiometabolic risk (obese and insulin resistant subjects). Read More

    Insulin resistance is an independent predictor of erectile dysfunction in patients with gout.
    Korean J Intern Med 2017 Oct 12. Epub 2017 Oct 12.
    Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
    Background/aims: Gout is associated with metabolic disorders that are important risk factors for cardiovascular disease and erectile dysfunction (ED). We aimed to identify independent predictors of ED in patients with gout.

    Methods: From August 2014 to August 2015, male outpatients who were being treated for gout in our rheumatology clinic and healthy males without any history of inflammatory disease (control group) were studied. Read More

    Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins.
    Cell Rep 2017 Oct;21(2):393-402
    Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:
    Deterioration of metabolic health is a hallmark of aging and generally assumed to be detrimental to longevity. Exposure to a high-calorie diet impairs metabolism and accelerates aging; conversely, calorie restriction (CR) prevents age-related metabolic diseases and extends lifespan. However, it is unclear whether preservation of metabolic health is sufficient to extend lifespan. Read More

    1 OF 2104