125,978 results match your criteria Insulin Resistance


Obesity-Related Glomerulopathy: A Latent Change in Obesity Requiring More Attention.

Kidney Blood Press Res 2020 Jun 4:1-13. Epub 2020 Jun 4.

Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China,

Background: Obesity has become a major public health problem, and the prevalence of kidney diseases has increased in parallel. Among kidney diseases caused by metabolic disorders, obesity-related glomerulopathy (ORG) is secondary to obesity.

Summary: ORG is mainly caused by glomerular hyperfiltration, dysregulation of hormone and cytokine secretion in adipose tissues, and ectopic lipid accumulation in renal cells. Read More

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http://dx.doi.org/10.1159/000507784DOI Listing

Alternate-day fasting alleviates diabetes-induced glycolipid metabolism disorders: roles of FGF21 and bile acids.

J Nutr Biochem 2020 Apr 30;83:108403. Epub 2020 Apr 30.

Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, China; Department of Food Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA. Electronic address:

Glycolipid metabolism disorder is one of the causes of type 2 diabetes (T2D). Alternate-day fasting (ADF) is an effective dietary intervention to counteract T2D. The present study is aimed to determine the underlying mechanisms of the benefits of ADF metabolic on diabetes-induced glycolipid metabolism disorders in db/db mice. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2020.108403DOI Listing

High glucose induced endothelial cell reactive oxygen species via OGG1/PKC/NADPH oxidase pathway.

Life Sci 2020 Jun 1:117886. Epub 2020 Jun 1.

Department of Cardiology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui 241001, PR China. Electronic address:

Aims: Reactive oxygen species (ROS) caused by high glucose (HG) is involved in a lot of diseases including diabetes. However, the underlying mechanism of ROS induction by HG remains unclear. Emerging evidence has shown the 8-oxoguanine glycosylase (OGG1) is the main DNA glycosylase responsible for atherosclerosis, obesity, hepatic steatosis, and insulin resistance, and so on. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117886DOI Listing

THE MIDLIFE TRANSITION AND THE RISK OF CARDIOVASCULAR DISEASE AND CANCER I: MAGNITUDE AND MECHANISMS.

Am J Obstet Gynecol 2020 Jun 1. Epub 2020 Jun 1.

Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Heart disease and cancer are the leading causes of death in the U.S. In women the clinical appearance of both entities- coronary heart disease and cancer (breast, endometrium and ovary) escalate during the decades of the midlife transition encompassing the menopause. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.05.051DOI Listing

Increased chemerin serum levels in hyperandrogenic and normoandrogenic women from Argentina with polycystic ovary syndrome.

Gynecol Endocrinol 2020 Jun 4:1-5. Epub 2020 Jun 4.

Laboratorio de Fisio-patología OváricaCentro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.

To assess serum chemerin levels and investigate the association of chemerin with the hyperandrogenic and normoandrogenic phenotypes of Polycystic Ovary Syndrome (PCOS) and with the metabolic status of the analyzed population. A cross-sectional study was conducted on 106 women with PCOS and 60 healthy controls from Argentina. Patients were classified as showing a hyperandrogenic or normoandrogenic phenotype. Read More

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http://dx.doi.org/10.1080/09513590.2020.1769061DOI Listing

Telomere length is not altered in girls with idiopathic central precocious puberty treated with a GnRH analog - leuprolide acetate.

Gynecol Endocrinol 2020 Jun 4:1-5. Epub 2020 Jun 4.

Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Idiopathic central precocious puberty (iCPP) presents a disproportionate advancement of bone age and maturation, as well as metabolic and endocrinological changes that may be related to effects on telomere biology. To investigate the telomere length in iCPP girls treated with GnRHa. Observational case-control study with 85 girls, including 45 iCPP treated with GnRHa and 40 controls. Read More

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http://dx.doi.org/10.1080/09513590.2020.1770212DOI Listing

Circulating vaspin levels and nutritional status and insulin resistance in polycystic ovary syndrome.

Ginekol Pol 2020 ;91(5):251-255

Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Poland.

Objectives: The study aimed to assess the associations between circulating vaspin levels and nutritional status (assessed on tha basis of BMI) as well as insulin resistance in PCOS.

Material And Methods: Eighty-seven PCOS women, 48 obese and 39 normal weight, were enrolled in the cross-sectional study. Seventy-two Non-PCOS women, 41 obese and 31 normal weight, constituted a control group. Read More

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http://dx.doi.org/10.5603/GP.2020.0056DOI Listing
January 2020

RS9939609 FTO gene variant modified weight loss and insulin resistance after a partial meal-replacement hypocaloric diet.

Eur Rev Med Pharmacol Sci 2020 May;24(10):5573-5581

Center of Investigation of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain.

Objective: Some studies have demonstrated that the allele A of FTO rs9939609 is related to both higher waist circumference and body mass index. Subsequently, some designs related biochemical variables and body weight changes with this genetic variant. We decide to analyze the effects of rs9939609 genetic variant of FTO gene on metabolic parameters and weight loss secondary to partial meal replacements hypocaloric diets (pMRHDs) in obese subjects. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21343DOI Listing

Report of a member-led meeting: how stable isotope techniques can enhance human nutrition research.

Proc Nutr Soc 2020 Jun 4:1-7. Epub 2020 Jun 4.

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.

A Nutrition Society member-led meeting was held on 9 January 2020 at The University of Surrey, UK. Sixty people registered for the event, and all were invited to participate, either through chairing a session, presenting a '3 min lightning talk' or by presenting a poster. The meeting consisted of an introduction to the topic by Dr Barbara Fielding, with presentations from eight invited speakers. Read More

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http://dx.doi.org/10.1017/S0029665120007016DOI Listing

Adiponectin in onset and progression of T2DM with cardiac dysfunction in rats.

Hum Exp Toxicol 2020 Jun 4:960327120927446. Epub 2020 Jun 4.

School of Sciences, Indira Gandhi National Open University (IGNOU), Maidan Garhi, New Delhi, India.

Cardiovascular disease and type 2 diabetes mellitus (T2DM) patients have low level of adiponectin, however, till now the role of adiponectin in progression of 'T2DM with cardiac dysfunction' in animal model has not been characterized. Therefore, the aim of the present study was to develop and characterize T2DM animal model with cardiac dysfunction and to study the role of cardiac adiponectin expression in cardiac dysfunction. For this, Wistar rats (M/F) were fed a high-fat diet for different time periods: 3, 4 and 5 weeks and given a single, low-dose streptozotocin (25mg/kg), intraperitoneal injection 1 week prior to the experiments. Read More

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http://dx.doi.org/10.1177/0960327120927446DOI Listing

[Effects of Renshenjian Decoction on blood and urine metabonomics in type 2 diabetes rats based on ~1H-NMR].

Zhongguo Zhong Yao Za Zhi 2020 May;45(9):2186-2192

Guangdong Pharmaceutical University Guangzhou 510006, China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica, State Administration of Traditional Chinese Medicine Guangzhou 510006, China Chinese Medicine Quality Engineering Technology Research Center of Guangdong Province/Higher-Education Guangzhou 510006, China.

Proton nuclear magnetic resonance(~1H-NMR) is used to investigate the effect of Renshenjian Decoction on serum and urine metabolism of type 2 diabetic rats with insulin resistance induced by high-sugar and high-fat diet combined with low-dose streptozotocin(STZ). After the successful establishment of the insulin resistance model of type 2 diabetes, administration for 35 days, the serum and urine of rats were taken. Once the ~1H-NMR data have been collected and processed, PCA and OPLS-DA were used to analyze them. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200219.201DOI Listing

Prevalence of metabolic syndrome in four phenotypes of PCOS and its relationship with androgenic components among Iranian women: A cross-sectional study.

Int J Reprod Biomed (Yazd) 2020 Apr 30;18(4):253-264. Epub 2020 Apr 30.

Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Background: Polycystic ovary syndrome (PCOS) increases the risk of metabolic syndrome (MetS). Insulin resistance (IR) plays a major role in the pathophysiology of both PCOS and MetS.

Objective: This study was designed to compare the prevalence of MetS among different phenotypes of PCOS and its relationship with androgenic components. Read More

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http://dx.doi.org/10.18502/ijrm.v13i4.6888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218672PMC

Non-ischemic Cardiomyopathy: A Rare Adverse Effect of Clozapine.

Cureus 2020 Apr 30;12(4):e7901. Epub 2020 Apr 30.

Cardiology, Ascension Borgess Hospital, Kalamazoo, USA.

Clozapine is a dibenzodiazepine antipsychotic used for treatment-resistant schizophrenia. Its association with several side effects such as agranulocytosis, seizure, and insulin resistance is well known. Cardiac side effects such as myocarditis and cardiomyopathy are less common and have been seldom reported. Read More

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http://dx.doi.org/10.7759/cureus.7901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263404PMC

Prevalence of Normal-Weight Obesity in Community-Dwelling Chinese Older Adults: Results from the Beijing Longitudinal Study of Aging.

Diabetes Metab Syndr Obes 2020 12;13:1611-1617. Epub 2020 May 12.

Department of Geriatrics, Xuanwu Hospital, Capital Medical University, China National Clinical Research Center for Geriatric Medicine, Beijing 100053, People's Republic of China.

Objective: Normal-weight obesity (NWO) is characterized by high body fat percentage (BFP) in individuals with normal body mass index (BMI). This condition may increase the risk of serious health problems, such as cardiovascular diseases, diabetes, insulin resistance, hypertension, and metabolic syndrome. However, the prevalence of NWO in older adults in Beijing remains unclear. Read More

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http://dx.doi.org/10.2147/DMSO.S246884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229781PMC

Low Vitamin D Serum Level Is Associated with HDL-C Dyslipidemia and Increased Serum Thrombomodulin Levels of Insulin-Resistant Individuals.

Diabetes Metab Syndr Obes 2020 12;13:1599-1607. Epub 2020 May 12.

Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.

Background: Insulin-resistant individuals are known to have dyslipidemia and are predicted to be at high risk of cardiovascular events. Vitamin D deficiency was shown to be associated with dyslipidemia; however, the type of dyslipidemia associated with vitamin D deficiency in insulin-resistant individuals is not determined. Furthermore, there is evidence linking insulin resistance with low-grade inflammation suggesting levels of pro-inflammatory cytokines to be increased in insulin-resistant states. Read More

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http://dx.doi.org/10.2147/DMSO.S245742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231785PMC

Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing's Disease.

Diabetes Metab Syndr Obes 2020 11;13:1565-1574. Epub 2020 May 11.

Dipartimento di Promozione Della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro" (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy.

Purpose: To evaluate circulating irisin levels in patients with active and controlled Cushing's disease (CD).

Design: Forty-four patients with CD evaluated during the active phase and after 12 months of biochemical remission and 40 controls were recruited.

Methods: Phenotypic, anthropometric, hormonal and metabolic parameters, including insulin sensitivity estimation by homeostatic model of insulin resistance, Matsuda index and oral disposition index and circulating irisin levels were evaluated. Read More

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http://dx.doi.org/10.2147/DMSO.S249090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227819PMC

RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro.

Nat Commun 2020 Jun 3;11(1):2797. Epub 2020 Jun 3.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK.

Fat distribution is an independent cardiometabolic risk factor. However, its molecular and cellular underpinnings remain obscure. Here we demonstrate that two independent GWAS signals at RSPO3, which are associated with increased body mass index-adjusted waist-to-hip ratio, act to specifically increase RSPO3 expression in subcutaneous adipocytes. Read More

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http://dx.doi.org/10.1038/s41467-020-16592-zDOI Listing

Peroxisomal oxidation of erucic acid suppresses mitochondrial fatty acid oxidation by stimulating malonyl-CoA formation in the rat liver.

J Biol Chem 2020 Jun 3. Epub 2020 Jun 3.

School of Life Science, Hunan University of Science and Technology, China.

Feeding of rapeseed (canola) oil with a high erucic acid concentration is known to cause hepatic steatosis in animals. Mitochondrial fatty acid oxidation plays a central role in liver lipid homeostasis, so it is possible that hepatic metabolism of erucic acid might decrease mitochondrial fatty acid oxidation. However, the precise mechanistic relationship between erucic acid levels and mitochondrial fatty acid oxidation is unclear. Read More

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http://dx.doi.org/10.1074/jbc.RA120.013583DOI Listing

Protein and carbohydrate distribution among the meals: Effect on metabolic parameters of patients with type 2 diabetes: A single-blinded randomized controlled trial.

Br J Nutr 2020 Jun 4:1-24. Epub 2020 Jun 4.

Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Studies have revealed that the timing of macronutrient ingestion may influence body weight and glucose tolerance. We aimed to examine the effect of high protein versus high carbohydrate intake at the evening meal on metabolic parameters of patients with type 2 diabetes. This is a single-blinded, parallel, randomized controlled trial. Read More

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http://dx.doi.org/10.1017/S0007114520001944DOI Listing

Combined use of Diane-35 and metformin improves the ovulation in the PCOS rat model possibly via regulating glycolysis pathway.

Reprod Biol Endocrinol 2020 Jun 3;18(1):58. Epub 2020 Jun 3.

Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, 421001, China.

Background: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disease with unknown pathogenesis. However, the treatment of Diane-35 combined with metformin can improve the endocrine and ovulation of PCOS. In this study, we investigated the effects of Diane-35 combined with metformin (DM) treatment on ovulation and glucose metabolism in a PCOS rat model. Read More

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http://dx.doi.org/10.1186/s12958-020-00613-zDOI Listing

Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy.

J Hematol Oncol 2020 Jun 3;13(1):64. Epub 2020 Jun 3.

State Key Laboratory of Biotherapy, Laboratory of Oncogene, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.

Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF axis in cancer. However, clinical trials of the type I IGF receptor (IGF-IR)-targeted agents have been largely disappointing. Read More

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http://dx.doi.org/10.1186/s13045-020-00904-3DOI Listing

Ledeb. Ameliorates Hyperglycemia and Hepatic Steatosis in Ovariectomized Rats Fed a High-Fat Diet.

Nutrients 2020 Jun 1;12(6). Epub 2020 Jun 1.

Division of Applied Food System, Major of Food and Nutrition, Seoul Women's University, Seoul 01797, Korea.

Estrogen deficiency is associated with obesity, dyslipidemia, and increased insulin resistance in postmenopausal women. An efficient therapeutic agent prevents or improves postmenopausal conditions induced by estrogen deficiency. Here, we investigated the effects of aqueous Ledeb. Read More

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http://dx.doi.org/10.3390/nu12061631DOI Listing

Beneficial Effects of Isoflavones in the Kidney of Obese Rats Are Mediated by PPAR-Gamma Expression.

Nutrients 2020 Jun 1;12(6). Epub 2020 Jun 1.

Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo SP 04023-900, Brazil.

Several studies have demonstrated an important association between altered lipid metabolism and the development of kidney injury because of a high-fat diet. Fructose is also closely associated with renal injury. We opted for a combination of fructose and saturated fats in a diet (DH) that is a model known to induce renal damage in order to evaluate whether soy isoflavones could have promising use in the treatment of renal alterations. Read More

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http://dx.doi.org/10.3390/nu12061624DOI Listing

Moderate-intensity exercise and high-intensity interval training affect insulin sensitivity similarly in obese adults.

J Clin Endocrinol Metab 2020 Jun 3. Epub 2020 Jun 3.

Substrate Metabolism Laboratory, School of Kinesiology, University of Michigan, USA.

Objective: We compared the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on insulin sensitivity and other important metabolic adaptations in adults with obesity.

Methods: Thirty-one inactive adults with obesity (age: 31±6 years, BMI: 33±3 kg/m2) completed 12 weeks (4 sessions/week) of either HIIT (10x1-minute at 90%HRmax, 1-minute active recovery; n=16) or MICT (45 minutes at 70%HRmax; n=15). To assess the direct effects of exercise independent of weight/fat loss, participants were required to maintain body mass. Read More

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http://dx.doi.org/10.1210/clinem/dgaa345DOI Listing

Insulin resistance and depressed cardiac G6PD activity induced by glucocorticoid exposure during pregnancy are attenuated by maternal estrogen-progestin therapy.

Environ Toxicol Pharmacol 2020 May 31:103423. Epub 2020 May 31.

HOPE Cardiometabolic Research Team and Department of Physiology, College of Health Sciences, University of Ilorin, Nigeria. Electronic address:

This study aimed to investigate the effects of maternal combined oral contraceptive (COC) on dams that were exposed to late gestational glucocorticoids (GC). Twenty-four pregnant female rats were randomly allotted into 4 groups of 6 dams each. Dams received COC (combination of 1. Read More

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http://dx.doi.org/10.1016/j.etap.2020.103423DOI Listing

No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial.

Am J Clin Nutr 2020 Jun 3. Epub 2020 Jun 3.

Department of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands.

Background: Effects of resveratrol on metabolic health have been studied in several short-term human clinical trials, with conflicting results. Next to dose, the duration of the clinical trials may explain the lack of effect in some studies, but long-term studies are still limited.

Objectives: The objective of this study was to investigate the effects of 6-mo resveratrol supplementation on metabolic health outcome parameters. Read More

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http://dx.doi.org/10.1093/ajcn/nqaa125DOI Listing

A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma.

PLoS Comput Biol 2020 Jun 3;16(6):e1007882. Epub 2020 Jun 3.

Nestlé Research, EPFL Innovation Park, Lausanne, Switzerland.

Molecular quantitative trait locus (QTL) analyses are increasingly popular to explore the genetic architecture of complex traits, but existing studies do not leverage shared regulatory patterns and suffer from a large multiplicity burden, which hampers the detection of weak signals such as trans associations. Here, we present a fully multivariate proteomic QTL (pQTL) analysis performed with our recently proposed Bayesian method LOCUS on data from two clinical cohorts, with plasma protein levels quantified by mass-spectrometry and aptamer-based assays. Our two-stage study identifies 136 pQTL associations in the first cohort, of which >80% replicate in the second independent cohort and have significant enrichment with functional genomic elements and disease risk loci. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1007882DOI Listing

Betanin effect on PPAR-α and SREBP-1c expression in NMRI mice model of steatohepatitis with fibrosis.

Physiol Int 2020 Mar;107(1):67-81

2Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Betanin is a betacyanin with antioxidant and anti-inflammatory activities whose effects were investigated in a nonalcoholic steatohepatitis (NASH) model.

Main Methods: Ninety-six male naval medical research institute (NMRI) mice were divided into eight groups (n = 12) including normal control, high fat diet (HFD), Sham, and positive control treated with trans-chalcone. Three experimental groups were treated with 5 mg/kg, 10 mg/kg or 20 mg/kg betanin, and a betanin protective group was also defined. Read More

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http://dx.doi.org/10.1556/2060.2020.00001DOI Listing

Association of serum levels of secreted frizzled-related protein 5 and Wnt member 5a with glomerular filtration rate in patients with type 2 diabetes mellitus and chronic renal disease: a cross-sectional study.

Sao Paulo Med J 2020 Mar 1;138(2):133-139. Epub 2020 Jun 1.

Facultad de Biología, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, Mexico.

Background: Diabetic nephropathy is a common complication of chronic kidney disease (CKD). -Inflammation in the kidneys is crucial for promoting development and progression of this complication. Wnt member 5a (Wnt5a) and secreted frizzled-related protein 5 (Sfrp5) are proinflammatory proteins associated with insulin resistance and chronic low-grade adipose tissue inflammation. Read More

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http://dx.doi.org/10.1590/1516-3180.2019.0304.r2.09122019DOI Listing

Associations between metabolic syndrome and gynecologic cancer.

Obstet Gynecol Sci 2020 May 31;63(3):215-224. Epub 2020 Mar 31.

Department of Obstetrics and Gynecology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.

Metabolic syndrome (MetS) is a group of risk factors that causes cardiovascular and diabetic morbidity and mortality, which is diagnosed by central obesity, dyslipidemia, hyperglycemia, and hypertension. Increasing epidemiological data and experimental results indicate that the presence of MetS increases the incidence of common malignancies and related mortality. Epidemiological studies have previously reported an association of endometrial cancer occurrence with MetS. Read More

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http://dx.doi.org/10.5468/ogs.2020.63.3.215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231948PMC

Genetic Architecture of Circulating Very-Long-Chain (C24:0 and C22:0) Ceramide Concentrations.

J Lipid Atheroscler 2020 3;9(1):172-183. Epub 2020 Jan 3.

Diabetic Cardiovascular Disease Center, Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Objective: Total ceramide concentrations are linked with increased insulin resistance and cardiac dysfunction. However, recent studies have demonstrated that plasma concentrations of specific very-long-chain fatty ceramides (C24:0 and C22:0) are associated with a reduced incidence of coronary heart disease and all-cause mortality. We hypothesized that specific genetic loci are associated with plasma C22:0 and C24:0 concentrations. Read More

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http://dx.doi.org/10.12997/jla.2020.9.1.172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266332PMC
January 2020

Herbal formulation MIT ameliorates high-fat diet-induced non-alcoholic fatty liver disease.

Integr Med Res 2020 Dec 14;9(4):100422. Epub 2020 May 14.

Second Division of Clinical Medicine, School of Korean Medicine, Pusan National University, Busandaehak-ro 49, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do 50612, Republic of Korea.

Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases and is caused by obesity, diabetes, high blood pressure, and insulin resistance. Many studies have explored novel candidates to treat NAFLD using herbal medicines owing to their fewer side effects. In this study, we examined the effect of MIT, an herbal formula comprising , , and , on the murine model of NAFLD. Read More

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http://dx.doi.org/10.1016/j.imr.2020.100422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260683PMC
December 2020

Myocardial Involvement in Chagas Disease and Insulin Resistance: A Non-Metabolic Model of Cardiomyopathy.

Glob Heart 2020 Apr 24;15(1):36. Epub 2020 Apr 24.

Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Alberta, CA.

Background: Heart failure (HF) and type 2 Diabetes Mellitus (T2DM) represent two chronic interrelated conditions accounting for significant morbidity and mortality worldwide. Insulin resistance (IR) has been identified as a risk factor for HF; however, the risk of IR that HF confers has not been well elucidated. The present study aims to analyze the association between myocardial involvement in Chronic Chagas Cardiomyopathy (CCM) and IR, taking advantage of this non-metabolic model of the disease. Read More

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http://dx.doi.org/10.5334/gh.793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218788PMC

The role of thyroid hormone in metabolism and metabolic syndrome.

Ther Adv Endocrinol Metab 2020 13;11:2042018820917869. Epub 2020 May 13.

Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro-Brazil.

Metabolic syndrome (MetS) and thyroid dysfunction are common in clinical practice. The objectives of this review are to discuss some proposed mechanisms by which thyroid dysfunctions may lead to MetS, to describe the bidirectional relationship between thyroid hormones (THs) and adiposity and finally, to resume a list of recent studies in humans that evaluated possible associations between thyroid hormone status and MetS or its clinical components. Not solely THs, but also its metabolites regulate metabolic rate, influencing adiposity. Read More

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http://dx.doi.org/10.1177/2042018820917869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238803PMC

Dysfunctional oxidative phosphorylation shunts branched-chain amino acid catabolism onto lipogenesis in skeletal muscle.

EMBO J 2020 Jun 3:e103812. Epub 2020 Jun 3.

Departamento de Biología Molecular, Centro de Biología Molecular "Severo Ochoa" (CBMSO), Universidad Autónoma de Madrid, Madrid, Spain.

It is controversial whether mitochondrial dysfunction in skeletal muscle is the cause or consequence of metabolic disorders. Herein, we demonstrate that in vivo inhibition of mitochondrial ATP synthase in muscle alters whole-body lipid homeostasis. Mice with restrained mitochondrial ATP synthase activity presented intrafiber lipid droplets, dysregulation of acyl-glycerides, and higher visceral adipose tissue deposits, poising these animals to insulin resistance. Read More

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http://dx.doi.org/10.15252/embj.2019103812DOI Listing

Insulin clearance as the major player in the hyperinsulinaemia of black African men without diabetes.

Diabetes Obes Metab 2020 Jun 2. Epub 2020 Jun 2.

Department of Diabetes, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.

Aims: Despite their low levels of ectopic fat accumulation, populations of African ancestry exhibit hyperinsulinaemia and increased metabolic risk. We aimed to investigate relationships between insulin clearance, insulin secretion, hepatic fat accumulation and insulin sensitivity in black African (BA) and white European (WE) men.

Methods: 23 BA and 23 WE men with normal glucose tolerance, matched for age and body mass index, underwent a hyperglycaemic clamp to measure insulin secretion and clearance; hyperinsulinaemic-euglycaemic clamp with stable glucose isotope infusion to measure whole-body and hepatic-specific insulin sensitivity; and magnetic resonance imaging to quantify intrahepatic lipid (IHL) RESULTS: BA men had higher glucose-stimulated peripheral insulin levels (48. Read More

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http://dx.doi.org/10.1111/dom.14101DOI Listing

Effects of Bitter Melon and a Chromium Propionate Complex on Symptoms of Insulin Resistance and Type 2 Diabetes in Rat Models.

Biol Trace Elem Res 2020 Jun 2. Epub 2020 Jun 2.

Institute of Human Nutrition and Dietetics, The Poznań University of Life Sciences, Wojska Polskiego 31, 60-624, Poznań, Poland.

Trivalent chromium (Cr) and bitter melon (Momordica charantia L., BM) have been shown to independently interact with the insulin signaling pathway leading to improvements in the symptoms of insulin resistance and diabetes in some animal models and human subjects. The aim of this study was to examine whether the combination of the two nutritional supplements could potentially have additive effects on treating these conditions in high-fat-fed streptozotocin (STZ)-induced diabetic rats. Read More

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http://dx.doi.org/10.1007/s12011-020-02202-yDOI Listing

Renal denervation improves vascular endothelial dysfunction by inducing autophagy via AMPK/mTOR signaling activation in a rat model of type 2 diabetes mellitus with insulin resistance.

Acta Diabetol 2020 Jun 1. Epub 2020 Jun 1.

Department of Cardiology, Tianjin First Central Hospital, Tianjin, China.

Background: Recent clinical and animal studies have shown that renal denervation (RDN) improves insulin sensitivity and endothelial dysfunction. However, the specific mechanism remains incompletely understood. The purpose of this study is to investigate the effects of RDN on endothelial dysfunction of type 2 diabetes mellitus (TDM) rat models with insulin resistance and to explore the underlying molecular mechanisms. Read More

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http://dx.doi.org/10.1007/s00592-020-01532-6DOI Listing

Stratification and prediction of drug synergy based on target functional similarity.

NPJ Syst Biol Appl 2020 Jun 2;6(1):16. Epub 2020 Jun 2.

RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine (JRC-COMBINE), Aachen, Germany.

Drug combinations can expand therapeutic options and address cancer's resistance. However, the combinatorial space is enormous precluding its systematic exploration. Therefore, synergy prediction strategies are essential. Read More

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http://dx.doi.org/10.1038/s41540-020-0136-xDOI Listing

Does early weaning shape future endocrine and metabolic disorders? Lessons from animal models.

J Dev Orig Health Dis 2020 Jun 3:1-11. Epub 2020 Jun 3.

Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Obesity and its complications occur at alarming rates worldwide. Epidemiological data have associated perinatal conditions, such as malnutrition, with the development of some disorders, such as obesity, dyslipidemia, diabetes, and cardiovascular diseases, in childhood and adulthood. Exclusive breastfeeding has been associated with protection against long-term chronic diseases. Read More

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http://dx.doi.org/10.1017/S2040174420000410DOI Listing

Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states.

Lipids Health Dis 2020 Jun 2;19(1):121. Epub 2020 Jun 2.

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing, 100730, China.

Background: Previous studies on the effects of lipotoxicity and oxidative stress on islet beta cell function mainly focused on patients with diabetes, whereas studies on normal glucose tolerance (NGT) are few. The aim of this study was to explore the relationships among triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), oxidative stress indicators, insulin resistance, and beta cell function in populations with different glucose and lipid metabolism states.

Methods: A total of 517 individuals were recruited from a rural community in Beijing, China. Read More

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http://dx.doi.org/10.1186/s12944-020-01303-wDOI Listing

Cathepsin gene expression in abdominal subcutaneous adipose tissue of obese/overweight humans.

Adipocyte 2020 Jan;9(1):246-252

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+ , Maastricht, The Netherlands.

Cathepsin L1 (CTSL1) and B (CTSB) are lysosomal proteases, of which the expression and activity are impaired in adipose tissue (AT) of obese rodents, indicating AT lysosomal dysfunction. Here we assess the relation between abdominal subcutaneous AT (SCAT) CTSL1 and CTSB expression (qRT-PCR), body composition and tissue-specific insulin resistance in 77 overweight/obese (BMI: 225.6-38. Read More

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http://dx.doi.org/10.1080/21623945.2020.1775035DOI Listing
January 2020

Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults.

Nutrients 2020 May 30;12(6). Epub 2020 May 30.

Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan NSW 2308, Australia.

Targeting kinases linked to insulin resistance (IR) and inflammation may help in reducing the risk of type 2 diabetes (T2D) and Alzheimer's disease (AD) in its early stages. This study aimed to determine whether DHA-rich fish oil supplementation reduces glycogen synthase kinase (GSK-3), which is linked to both IR and AD. Baseline and post-intervention plasma samples from 58 adults with abdominal obesity (Age: 51. Read More

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http://dx.doi.org/10.3390/nu12061612DOI Listing

SIRT1 Activation by L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats.

Molecules 2020 May 29;25(11). Epub 2020 May 29.

Department of Pharmacology and Pharmacotherapy, University of Debrecen, Faculty of Medicine, Nagyerdei krt. 98, H-4032 Debrecen, Hungary.

Background: L., commonly known as field horsetail is a perennial fern of which extracts are rich sources of phenolic compounds, flavonoids, and phenolic acids. Activation of SIRT1 that was shown to be involved in well-known signal pathways of diabetic cardiomyopathy has a protective effect against oxidative stress, inflammatory processes, and apoptosis that are the basis of diseases such as obesity, diabetes mellitus, or cardiovascular diseases. Read More

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http://dx.doi.org/10.3390/molecules25112541DOI Listing

The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease.

Int J Mol Sci 2020 May 29;21(11). Epub 2020 May 29.

Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.

Nonalcoholic fatty liver disease (NAFLD) consists of the entire spectrum of fatty liver disease in patients without significant alcohol consumption, ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) to cirrhosis, with NASH recently shown as an important cause of hepatocellular carcinoma (HCC). There is a close relationship between insulin resistance (IR) and NAFLD, with a five-fold higher prevalence of NAFLD in patients with type 2 diabetes (T2DM) compared to that in patients without T2DM. IR is involved in the progression of disease conditions such as steatosis and NASH, as well as hepatic fibrosis progression. Read More

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http://dx.doi.org/10.3390/ijms21113863DOI Listing

Whole-body Electromyostimulation plus Caloric Restriction in Metabolic Syndrome.

Int J Sports Med 2020 Jun 2. Epub 2020 Jun 2.

School of Sports and Exercise Sciences, Telematic University San Raffaele Rome Srl, Roma, Italy.

We investigated early effects of Whole-Body Electromyostimulation added to hypocaloric diet on metabolic syndrome features in sedentary middle-aged individuals. We randomly assigned 25 patients to Whole-Body Electromyostimulation plus caloric restriction or caloric restriction alone for 26 weeks. Anthropometrics, blood pressure, fasting glucose and insulin, HOMA-IR, glycated hemoglobin, lipids, uric acid, creatinphosphokynase, C-reactive protein were assessed. Read More

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http://dx.doi.org/10.1055/a-1171-2003DOI Listing

Adropin inhibited tilapia hepatic glucose output and triglyceride accumulation via AMPK activation.

J Endocrinol 2020 May 1. Epub 2020 May 1.

Q Jiang, College of Life Sciences, Sichuan University, Chengdu, China.

Adropin plays a role in the maintenance of energy homeostasis, insulin resistance prevention, and impaired glucose tolerance. However, the molecular mechanisms by which adropin affects hepatic glucose and lipid metabolism in vitro are not entirely understood. This study intended to examine the roles and underlying mechanisms of adropin in glucose and lipid metabolism in Nile tilapia. Read More

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http://dx.doi.org/10.1530/JOE-20-0077DOI Listing

Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model.

Biochim Biophys Acta Mol Basis Dis 2020 May 30:165849. Epub 2020 May 30.

Rocky Mountain Regional VA Medical Center, USA; Department of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA. Electronic address:

Alzheimer's disease (AD) often coexists with other aging-associated diseases including obesity, diabetes, hypertension, and cardiovascular diseases. The early stage of these comorbidities is known as metabolic syndrome (MetS) which is highly prevalent in mid-life. An important cause of MetS is the deficiency of SIRT3, a mitochondrial deacetylase which enhances the functions of critical mitochondrial proteins, including metabolic enzymes, by deacetylation. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165849DOI Listing